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Protein

Transmembrane protein 59

Gene

TMEM59

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Acts as a regulator of autophagy in response to S.aureus infection by promoting activation of LC3 (MAP1LC3A, MAP1LC3B or MAP1LC3C). Acts by interacting with ATG16L1, leading to promote a functional complex between LC3 and ATG16L1 and promoting LC3 lipidation and subsequent activation of autophagy. Modulates the O-glycosylation and complex N-glycosylation steps occurring during the Golgi maturation of several proteins such as APP, BACE1, SEAP or PRNP. Inhibits APP transport to the cell surface and further shedding.2 Publications

GO - Molecular functioni

GO - Biological processi

  • autophagy Source: UniProtKB-KW
  • negative regulation of establishment of protein localization to plasma membrane Source: UniProtKB
  • negative regulation of protein glycosylation in Golgi Source: UniProtKB
  • negative regulation of protein processing Source: UniProtKB
  • positive regulation of autophagy Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Autophagy

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 59
Alternative name(s):
Liver membrane-bound protein
Gene namesi
Name:TMEM59
Synonyms:C1orf8
ORF Names:HSPC001, UNQ169/PRO195
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:1239. TMEM59.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini36 – 238203ExtracellularSequence analysisAdd
BLAST
Transmembranei239 – 25921HelicalSequence analysisAdd
BLAST
Topological domaini260 – 32364CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
  • Golgi cis cisterna Source: UniProtKB
  • Golgi medial cisterna Source: UniProtKB
  • Golgi membrane Source: UniProtKB-SubCell
  • Golgi trans cisterna Source: UniProtKB
  • integral component of membrane Source: UniProtKB-KW
  • late endosome Source: UniProtKB
  • late endosome membrane Source: UniProtKB-SubCell
  • lysosomal membrane Source: UniProtKB-SubCell
  • lysosome Source: UniProtKB
  • plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Endosome, Golgi apparatus, Lysosome, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi268 – 2681Y → A or F: Impaired ability to activate LC3. 1 Publication
Mutagenesisi268 – 2681Y → W: Does not affect ability to activate LC3. 1 Publication
Mutagenesisi272 – 2721E → A or D: Does not affect ability to activate LC3. 1 Publication
Mutagenesisi277 – 2771Y → A: Impaired ability to activate LC3. 1 Publication
Mutagenesisi277 – 2771Y → W or F: Does not affect ability to activate LC3. 1 Publication
Mutagenesisi280 – 2801L → A or V: Impaired ability to activate LC3. 1 Publication

Organism-specific databases

PharmGKBiPA25620.

Polymorphism and mutation databases

BioMutaiTMEM59.
DMDMi18202737.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3535Sequence analysisAdd
BLAST
Chaini36 – 323288Transmembrane protein 59PRO_0000003003Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi90 – 901N-linked (GlcNAc...)1 Publication
Modified residuei303 – 3031PhosphothreonineBy similarity

Post-translational modificationi

N-glycosylated.1 Publication

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

EPDiQ9BXS4.
MaxQBiQ9BXS4.
PaxDbiQ9BXS4.
PeptideAtlasiQ9BXS4.
PRIDEiQ9BXS4.

PTM databases

iPTMnetiQ9BXS4.
PhosphoSiteiQ9BXS4.
SwissPalmiQ9BXS4.

Expressioni

Gene expression databases

BgeeiENSG00000116209.
CleanExiHS_TMEM59.
ExpressionAtlasiQ9BXS4. baseline and differential.
GenevisibleiQ9BXS4. HS.

Organism-specific databases

HPAiHPA007410.

Interactioni

Subunit structurei

Interacts with ATG16L1.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
ATG16L1Q676U56EBI-7054441,EBI-535909

Protein-protein interaction databases

BioGridi114904. 9 interactions.
IntActiQ9BXS4. 6 interactions.
MINTiMINT-8201752.
STRINGi9606.ENSP00000234831.

Structurei

3D structure databases

ProteinModelPortaliQ9BXS4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi263 – 28119ATG16L1-binding motifAdd
BLAST

Domaini

The ATG16L1-binding motif mediates interaction with ATG16L1 and promotes autophagy.1 Publication

Sequence similaritiesi

Belongs to the TMEM59 family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IIST. Eukaryota.
ENOG410XTCW. LUCA.
GeneTreeiENSGT00390000008279.
HOVERGENiHBG018206.
InParanoidiQ9BXS4.
OMAiYGDLEYM.
OrthoDBiEOG091G0EVN.
PhylomeDBiQ9BXS4.
TreeFamiTF331226.

Family and domain databases

InterProiIPR022065. Uncharacterised_TMEM59.
[Graphical view]
PfamiPF12280. BSMAP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9BXS4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAPKGSLWV RTQLGLPPLL LLTMALAGGS GTASAEAFDS VLGDTASCHR
60 70 80 90 100
ACQLTYPLHT YPKEEELYAC QRGCRLFSIC QFVDDGIDLN RTKLECESAC
110 120 130 140 150
TEAYSQSDEQ YACHLGCQNQ LPFAELRQEQ LMSLMPKMHL LFPLTLVRSF
160 170 180 190 200
WSDMMDSAQS FITSSWTFYL QADDGKIVIF QSKPEIQYAP HLEQEPTNLR
210 220 230 240 250
ESSLSKMSYL QMRNSQAHRN FLEDGESDGF LRCLSLNSGW ILTTTLVLSV
260 270 280 290 300
MVLLWICCAT VATAVEQYVP SEKLSIYGDL EFMNEQKLNR YPASSLVVVR
310 320
SKTEDHEEAG PLPTKVNLAH SEI
Length:323
Mass (Da):36,223
Last modified:June 1, 2001 - v1
Checksum:i0926AB7D12D1B902
GO

Sequence cautioni

The sequence AAC39890 differs from that shown. Reason: Frameshift at position 6. Curated
The sequence AAH03106 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti209 – 2091Y → SD in AAH16374 (PubMed:15489334).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti46 – 461A → V.1 Publication
Corresponds to variant rs41294776 [ dbSNP | Ensembl ].
VAR_063397

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF290615 mRNA. Translation: AAK28026.1.
AF047439 mRNA. Translation: AAC39890.1. Frameshift.
AY359029 mRNA. Translation: AAQ89388.1.
AK075187 mRNA. Translation: BAG52079.1.
AK075505 mRNA. Translation: BAC11658.1.
AL353898 Genomic DNA. Translation: CAI22665.1.
CH471059 Genomic DNA. Translation: EAX06707.1.
BC003106 mRNA. Translation: AAH03106.1. Different initiation.
BC016374 mRNA. Translation: AAH16374.1.
BC095464 mRNA. Translation: AAH95464.1.
CCDSiCCDS586.1.
RefSeqiNP_001291972.1. NM_001305043.1.
NP_001291978.1. NM_001305049.1.
NP_001291979.1. NM_001305050.1.
NP_001291980.1. NM_001305051.1.
NP_001291981.1. NM_001305052.1.
NP_001291995.1. NM_001305066.1.
NP_004863.2. NM_004872.4.
UniGeneiHs.118947.
Hs.523262.
Hs.558618.
Hs.684693.
Hs.689423.

Genome annotation databases

EnsembliENST00000234831; ENSP00000234831; ENSG00000116209.
GeneIDi9528.
KEGGihsa:9528.
UCSCiuc001cwp.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF290615 mRNA. Translation: AAK28026.1.
AF047439 mRNA. Translation: AAC39890.1. Frameshift.
AY359029 mRNA. Translation: AAQ89388.1.
AK075187 mRNA. Translation: BAG52079.1.
AK075505 mRNA. Translation: BAC11658.1.
AL353898 Genomic DNA. Translation: CAI22665.1.
CH471059 Genomic DNA. Translation: EAX06707.1.
BC003106 mRNA. Translation: AAH03106.1. Different initiation.
BC016374 mRNA. Translation: AAH16374.1.
BC095464 mRNA. Translation: AAH95464.1.
CCDSiCCDS586.1.
RefSeqiNP_001291972.1. NM_001305043.1.
NP_001291978.1. NM_001305049.1.
NP_001291979.1. NM_001305050.1.
NP_001291980.1. NM_001305051.1.
NP_001291981.1. NM_001305052.1.
NP_001291995.1. NM_001305066.1.
NP_004863.2. NM_004872.4.
UniGeneiHs.118947.
Hs.523262.
Hs.558618.
Hs.684693.
Hs.689423.

3D structure databases

ProteinModelPortaliQ9BXS4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114904. 9 interactions.
IntActiQ9BXS4. 6 interactions.
MINTiMINT-8201752.
STRINGi9606.ENSP00000234831.

PTM databases

iPTMnetiQ9BXS4.
PhosphoSiteiQ9BXS4.
SwissPalmiQ9BXS4.

Polymorphism and mutation databases

BioMutaiTMEM59.
DMDMi18202737.

Proteomic databases

EPDiQ9BXS4.
MaxQBiQ9BXS4.
PaxDbiQ9BXS4.
PeptideAtlasiQ9BXS4.
PRIDEiQ9BXS4.

Protocols and materials databases

DNASUi9528.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000234831; ENSP00000234831; ENSG00000116209.
GeneIDi9528.
KEGGihsa:9528.
UCSCiuc001cwp.4. human.

Organism-specific databases

CTDi9528.
GeneCardsiTMEM59.
HGNCiHGNC:1239. TMEM59.
HPAiHPA007410.
neXtProtiNX_Q9BXS4.
PharmGKBiPA25620.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IIST. Eukaryota.
ENOG410XTCW. LUCA.
GeneTreeiENSGT00390000008279.
HOVERGENiHBG018206.
InParanoidiQ9BXS4.
OMAiYGDLEYM.
OrthoDBiEOG091G0EVN.
PhylomeDBiQ9BXS4.
TreeFamiTF331226.

Miscellaneous databases

ChiTaRSiTMEM59. human.
GeneWikiiTMEM59.
GenomeRNAii9528.
PROiQ9BXS4.

Gene expression databases

BgeeiENSG00000116209.
CleanExiHS_TMEM59.
ExpressionAtlasiQ9BXS4. baseline and differential.
GenevisibleiQ9BXS4. HS.

Family and domain databases

InterProiIPR022065. Uncharacterised_TMEM59.
[Graphical view]
PfamiPF12280. BSMAP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTMM59_HUMAN
AccessioniPrimary (citable) accession number: Q9BXS4
Secondary accession number(s): B3KQL7
, O75393, Q4VBP9, Q5T705, Q96KX7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: June 1, 2001
Last modified: September 7, 2016
This is version 130 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.