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Q9BXS1

- IDI2_HUMAN

UniProt

Q9BXS1 - IDI2_HUMAN

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Protein

Isopentenyl-diphosphate delta-isomerase 2

Gene

IDI2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP).1 Publication

Catalytic activityi

Isopentenyl diphosphate = dimethylallyl diphosphate.

Cofactori

Binds 1 magnesium ion per subunit.By similarity

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei36 – 361SubstrateBy similarity
Metal bindingi40 – 401MagnesiumBy similarity
Metal bindingi51 – 511MagnesiumBy similarity
Binding sitei70 – 701SubstrateBy similarity
Binding sitei74 – 741SubstrateBy similarity
Active sitei86 – 861By similarity
Binding sitei87 – 871SubstrateBy similarity
Metal bindingi146 – 1461MagnesiumBy similarity
Active sitei148 – 1481By similarity
Metal bindingi148 – 1481MagnesiumBy similarity

GO - Molecular functioni

  1. hydrolase activity Source: InterPro
  2. isopentenyl-diphosphate delta-isomerase activity Source: UniProtKB
  3. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. cholesterol biosynthetic process Source: Reactome
  2. dimethylallyl diphosphate biosynthetic process Source: UniProtKB-UniPathway
  3. isopentenyl diphosphate metabolic process Source: MGI
  4. isoprenoid biosynthetic process Source: UniProtKB
  5. small molecule metabolic process Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Cholesterol biosynthesis, Cholesterol metabolism, Isoprene biosynthesis, Lipid biosynthesis, Lipid metabolism, Steroid biosynthesis, Steroid metabolism, Sterol biosynthesis, Sterol metabolism

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

BioCyciMetaCyc:HS07522-MONOMER.
ReactomeiREACT_9405. Cholesterol biosynthesis.
UniPathwayiUPA00059; UER00104.

Names & Taxonomyi

Protein namesi
Recommended name:
Isopentenyl-diphosphate delta-isomerase 2 (EC:5.3.3.2)
Alternative name(s):
Isopentenyl pyrophosphate isomerase 2
Short name:
IPP isomerase 2
Short name:
IPPI2
Gene namesi
Name:IDI2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 10

Organism-specific databases

HGNCiHGNC:23487. IDI2.

Subcellular locationi

Peroxisome 1 Publication

GO - Cellular componenti

  1. cytosol Source: Reactome
  2. peroxisome Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Peroxisome

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134935136.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 227227Isopentenyl-diphosphate delta-isomerase 2PRO_0000205228Add
BLAST

Proteomic databases

PaxDbiQ9BXS1.
PRIDEiQ9BXS1.

PTM databases

PhosphoSiteiQ9BXS1.

Expressioni

Tissue specificityi

Detected in skeletal muscle.1 Publication

Gene expression databases

BgeeiQ9BXS1.
CleanExiHS_IDI2.
GenevestigatoriQ9BXS1.

Organism-specific databases

HPAiHPA041254.

Interactioni

Protein-protein interaction databases

BioGridi124870. 13 interactions.
IntActiQ9BXS1. 1 interaction.
STRINGi9606.ENSP00000277517.

Structurei

Secondary structure

227
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi1 – 44
Helixi11 – 166
Beta strandi20 – 245
Beta strandi30 – 356
Helixi36 – 394
Helixi42 – 454
Turni46 – 483
Beta strandi51 – 599
Beta strandi65 – 706
Beta strandi75 – 773
Beta strandi84 – 874
Beta strandi90 – 923
Helixi93 – 964
Helixi99 – 1013
Helixi102 – 11615
Turni120 – 1223
Helixi125 – 1273
Beta strandi128 – 15629
Turni165 – 1673
Beta strandi168 – 1747
Helixi176 – 18813
Helixi195 – 2039
Helixi205 – 2084
Helixi209 – 2113
Helixi216 – 2183

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2PNYX-ray1.81A1-227[»]
ProteinModelPortaliQ9BXS1.
SMRiQ9BXS1. Positions 1-227.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9BXS1.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini49 – 199151Nudix hydrolasePROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi225 – 2273Microbody targeting signalSequence Analysis

Sequence similaritiesi

Belongs to the IPP isomerase type 1 family.Curated
Contains 1 nudix hydrolase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG1443.
GeneTreeiENSGT00390000008527.
HOGENOMiHOG000274106.
HOVERGENiHBG002995.
InParanoidiQ9BXS1.
KOiK01823.
OMAiIRYISME.
OrthoDBiEOG7H4DVK.
PhylomeDBiQ9BXS1.
TreeFamiTF300129.

Family and domain databases

Gene3Di3.90.79.10. 1 hit.
InterProiIPR011876. IsopentenylPP_isomerase_typ1.
IPR000086. NUDIX_hydrolase_dom.
IPR015797. NUDIX_hydrolase_dom-like.
[Graphical view]
PANTHERiPTHR10885. PTHR10885. 1 hit.
PfamiPF00293. NUDIX. 1 hit.
[Graphical view]
PIRSFiPIRSF018427. Isopntndiph_ism. 1 hit.
SUPFAMiSSF55811. SSF55811. 1 hit.
TIGRFAMsiTIGR02150. IPP_isom_1. 1 hit.
PROSITEiPS51462. NUDIX. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9BXS1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSDINLDWVD RRQLQRLEEM LIVVDENDKV IGADTKRNCH LNENIEKGLL
60 70 80 90 100
HRAFSVVLFN TKNRILIQQR SDTKVTFPGY FTDSCSSHPL YNPAELEEKD
110 120 130 140 150
AIGVRRAAQR RLQAELGIPG EQISPEDIVF MTIYHHKAKS DRIWGEHEIC
160 170 180 190 200
YLLLVRKNVT LNPDPSETKS ILYLSQEELW ELLEREARGE VKVTPWLRTI
210 220
AERFLYRWWP HLDDVTPFVE LHKIHRV
Length:227
Mass (Da):26,753
Last modified:June 1, 2001 - v1
Checksum:i2FD79B076D94A7D0
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF291755 Genomic DNA. Translation: AAK29358.1.
AF271729
, AF271726, AF271727, AF271728 Genomic DNA. Translation: AAK49436.1.
AF271725 mRNA. Translation: AAK49437.1.
AK056950 mRNA. Translation: BAB71322.1.
BC017778 mRNA. Translation: AAH17778.1.
CCDSiCCDS7055.1.
RefSeqiNP_150286.1. NM_033261.2.
UniGeneiHs.591325.
Hs.9270.

Genome annotation databases

EnsembliENST00000277517; ENSP00000277517; ENSG00000148377.
GeneIDi91734.
KEGGihsa:91734.
UCSCiuc001ifv.1. human.

Polymorphism databases

DMDMi20978506.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF291755 Genomic DNA. Translation: AAK29358.1 .
AF271729
, AF271726 , AF271727 , AF271728 Genomic DNA. Translation: AAK49436.1 .
AF271725 mRNA. Translation: AAK49437.1 .
AK056950 mRNA. Translation: BAB71322.1 .
BC017778 mRNA. Translation: AAH17778.1 .
CCDSi CCDS7055.1.
RefSeqi NP_150286.1. NM_033261.2.
UniGenei Hs.591325.
Hs.9270.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2PNY X-ray 1.81 A 1-227 [» ]
ProteinModelPortali Q9BXS1.
SMRi Q9BXS1. Positions 1-227.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 124870. 13 interactions.
IntActi Q9BXS1. 1 interaction.
STRINGi 9606.ENSP00000277517.

PTM databases

PhosphoSitei Q9BXS1.

Polymorphism databases

DMDMi 20978506.

Proteomic databases

PaxDbi Q9BXS1.
PRIDEi Q9BXS1.

Protocols and materials databases

DNASUi 91734.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000277517 ; ENSP00000277517 ; ENSG00000148377 .
GeneIDi 91734.
KEGGi hsa:91734.
UCSCi uc001ifv.1. human.

Organism-specific databases

CTDi 91734.
GeneCardsi GC10M001064.
H-InvDB HIX0127248.
HGNCi HGNC:23487. IDI2.
HPAi HPA041254.
MIMi 615389. gene.
neXtProti NX_Q9BXS1.
PharmGKBi PA134935136.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG1443.
GeneTreei ENSGT00390000008527.
HOGENOMi HOG000274106.
HOVERGENi HBG002995.
InParanoidi Q9BXS1.
KOi K01823.
OMAi IRYISME.
OrthoDBi EOG7H4DVK.
PhylomeDBi Q9BXS1.
TreeFami TF300129.

Enzyme and pathway databases

UniPathwayi UPA00059 ; UER00104 .
BioCyci MetaCyc:HS07522-MONOMER.
Reactomei REACT_9405. Cholesterol biosynthesis.

Miscellaneous databases

EvolutionaryTracei Q9BXS1.
GenomeRNAii 91734.
NextBioi 77415.
PROi Q9BXS1.
SOURCEi Search...

Gene expression databases

Bgeei Q9BXS1.
CleanExi HS_IDI2.
Genevestigatori Q9BXS1.

Family and domain databases

Gene3Di 3.90.79.10. 1 hit.
InterProi IPR011876. IsopentenylPP_isomerase_typ1.
IPR000086. NUDIX_hydrolase_dom.
IPR015797. NUDIX_hydrolase_dom-like.
[Graphical view ]
PANTHERi PTHR10885. PTHR10885. 1 hit.
Pfami PF00293. NUDIX. 1 hit.
[Graphical view ]
PIRSFi PIRSF018427. Isopntndiph_ism. 1 hit.
SUPFAMi SSF55811. SSF55811. 1 hit.
TIGRFAMsi TIGR02150. IPP_isom_1. 1 hit.
PROSITEi PS51462. NUDIX. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "IDI2, a second isopentenyl diphosphate isomerase in mammals."
    Clizbe D.B., Owens M.L., Masuda K.R., Shackelford J.E., Krisans S.K.
    J. Biol. Chem. 282:6668-6676(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Skeletal muscle.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Skeletal muscle.

Entry informationi

Entry nameiIDI2_HUMAN
AccessioniPrimary (citable) accession number: Q9BXS1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 15, 2002
Last sequence update: June 1, 2001
Last modified: October 29, 2014
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3