ID TLR10_HUMAN Reviewed; 811 AA. AC Q9BXR5; A8K7L1; B3Y668; D1CS21; D1CS22; Q32MI7; Q32MI8; Q5FWG4; AC Q6UXL3; DT 31-JAN-2002, integrated into UniProtKB/Swiss-Prot. DT 17-OCT-2006, sequence version 2. DT 11-NOV-2015, entry version 142. DE RecName: Full=Toll-like receptor 10; DE AltName: CD_antigen=CD290; DE Flags: Precursor; GN Name=TLR10; ORFNames=UNQ315/PRO358; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RC TISSUE=Spleen; RX PubMed=11267672; DOI=10.1016/S0167-4781(00)00289-X; RA Chuang T.-H., Ulevitch R.J.; RT "Identification of hTLR10: a novel human Toll-like receptor RT preferentially expressed in immune cells."; RL Biochim. Biophys. Acta 1518:157-161(2001). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA]. RX PubMed=18810425; DOI=10.1007/s00251-008-0332-0; RA Nakajima T., Ohtani H., Satta Y., Uno Y., Akari H., Ishida T., RA Kimura A.; RT "Natural selection in the TLR-related genes in the course of primate RT evolution."; RL Immunogenetics 60:727-735(2008). RN [3] RP NUCLEOTIDE SEQUENCE [MRNA], AND VARIANT ASP-381. RX PubMed=19924287; DOI=10.1371/journal.pone.0007803; RA Georgel P., Macquin C., Bahram S.; RT "The heterogeneous allelic repertoire of human Toll-Like receptor RT (TLR) genes."; RL PLoS ONE 4:E7803-E7803(2009). RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RX PubMed=12975309; DOI=10.1101/gr.1293003; RA Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., RA Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., RA Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., RA Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., RA Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., RA Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., RA Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., RA Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., RA Wood W.I., Godowski P.J., Gray A.M.; RT "The secreted protein discovery initiative (SPDI), a large-scale RT effort to identify novel human secreted and transmembrane proteins: a RT bioinformatics assessment."; RL Genome Res. 13:2265-2270(2003). RN [5] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANTS HIS-241; LEU-369 RP AND VAL-775. RC TISSUE=Spleen; RX PubMed=14702039; DOI=10.1038/ng1285; RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.; RT "Complete sequencing and characterization of 21,243 full-length human RT cDNAs."; RL Nat. Genet. 36:40-45(2004). RN [6] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R., RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., RA Venter J.C.; RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases. RN [7] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANTS HIS-241; LEU-369; RP THR-473 AND VAL-775. RC TISSUE=Lymph; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA RT project: the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [8] RP X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) OF 622-776, AND SUBUNIT. RX PubMed=18332149; DOI=10.1074/jbc.C800001200; RA Nyman T., Stenmark P., Flodin S., Johansson I., Hammarstrom M., RA Nordlund P.; RT "The crystal structure of the human toll-like receptor 10 cytoplasmic RT domain reveals a putative signaling dimer."; RL J. Biol. Chem. 283:11861-11865(2008). CC -!- FUNCTION: Participates in the innate immune response to microbial CC agents. Acts via MYD88 and TRAF6, leading to NF-kappa-B CC activation, cytokine secretion and the inflammatory response (By CC similarity). {ECO:0000250}. CC -!- SUBUNIT: Binds MYD88 via their respective TIR domains (By CC similarity). Homodimer (Potential). {ECO:0000250, ECO:0000305}. CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Single-pass type I CC membrane protein {ECO:0000250}. CC -!- TISSUE SPECIFICITY: Highly expressed in spleen, lymph node, CC thymus, tonsil and at lower levels in lung. Highly expressed in CC promyelocytic HL-60 cells and in B-cell lines. CC -!- SIMILARITY: Belongs to the Toll-like receptor family. CC {ECO:0000305}. CC -!- SIMILARITY: Contains 15 LRR (leucine-rich) repeats. {ECO:0000305}. CC -!- SIMILARITY: Contains 1 LRRCT domain. {ECO:0000305}. CC -!- SIMILARITY: Contains 1 TIR domain. {ECO:0000255|PROSITE- CC ProRule:PRU00204}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AF296673; AAK26744.1; -; mRNA. DR EMBL; AB445680; BAG55077.1; -; mRNA. DR EMBL; DQ011504; AAY78479.1; -; mRNA. DR EMBL; DQ011505; AAY78480.1; -; mRNA. DR EMBL; AY358300; AAQ88667.1; -; mRNA. DR EMBL; AK292026; BAF84715.1; -; mRNA. DR EMBL; CH471069; EAW92897.1; -; Genomic_DNA. DR EMBL; BC089406; AAH89406.1; -; mRNA. DR EMBL; BC109111; AAI09112.1; -; mRNA. DR EMBL; BC109112; AAI09113.1; -; mRNA. DR CCDS; CCDS3445.1; -. DR RefSeq; NP_001017388.1; NM_001017388.2. DR RefSeq; NP_001182035.1; NM_001195106.1. DR RefSeq; NP_001182036.1; NM_001195107.1. DR RefSeq; NP_001182037.1; NM_001195108.1. DR RefSeq; NP_112218.2; NM_030956.3. DR RefSeq; XP_011512063.1; XM_011513761.1. DR RefSeq; XP_011512064.1; XM_011513762.1. DR UniGene; Hs.120551; -. DR UniGene; Hs.730896; -. DR PDB; 2J67; X-ray; 2.20 A; A/B=622-776. DR PDBsum; 2J67; -. DR ProteinModelPortal; Q9BXR5; -. DR SMR; Q9BXR5; 29-570, 628-776. DR STRING; 9606.ENSP00000308925; -. DR PhosphoSite; Q9BXR5; -. DR BioMuta; TLR10; -. DR DMDM; 116242819; -. DR PaxDb; Q9BXR5; -. DR PRIDE; Q9BXR5; -. DR Ensembl; ENST00000308973; ENSP00000308925; ENSG00000174123. DR Ensembl; ENST00000361424; ENSP00000354459; ENSG00000174123. DR Ensembl; ENST00000506111; ENSP00000421483; ENSG00000174123. DR Ensembl; ENST00000508334; ENSP00000424923; ENSG00000174123. DR Ensembl; ENST00000613579; ENSP00000478206; ENSG00000174123. DR Ensembl; ENST00000622002; ENSP00000478985; ENSG00000174123. DR GeneID; 81793; -. DR KEGG; hsa:81793; -. DR UCSC; uc003gti.3; human. DR CTD; 81793; -. DR GeneCards; TLR10; -. DR HGNC; HGNC:15634; TLR10. DR MIM; 606270; gene. DR neXtProt; NX_Q9BXR5; -. DR PharmGKB; PA38011; -. DR eggNOG; KOG4641; Eukaryota. DR eggNOG; COG4886; LUCA. DR GeneTree; ENSGT00760000119006; -. DR HOGENOM; HOG000008676; -. DR HOVERGEN; HBG023180; -. DR InParanoid; Q9BXR5; -. DR KO; K10171; -. DR OMA; PHMLFPN; -. DR OrthoDB; EOG7GN2M5; -. DR PhylomeDB; Q9BXR5; -. DR TreeFam; TF351113; -. DR Reactome; R-HSA-168142; Toll Like Receptor 10 (TLR10) Cascade. DR Reactome; R-HSA-5603037; IRAK4 deficiency (TLR5). DR Reactome; R-HSA-975871; MyD88 cascade initiated on plasma membrane. DR EvolutionaryTrace; Q9BXR5; -. DR GeneWiki; TLR10; -. DR GenomeRNAi; 81793; -. DR NextBio; 35489020; -. DR PRO; PR:Q9BXR5; -. DR Proteomes; UP000005640; Chromosome 4. DR Bgee; Q9BXR5; -. DR CleanEx; HS_TLR10; -. DR ExpressionAtlas; Q9BXR5; baseline and differential. DR Genevisible; Q9BXR5; HS. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0016020; C:membrane; TAS:UniProtKB. DR GO; GO:0005886; C:plasma membrane; TAS:Reactome. DR GO; GO:0004888; F:transmembrane signaling receptor activity; TAS:UniProtKB. DR GO; GO:0006955; P:immune response; NAS:UniProtKB. DR GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-KW. DR GO; GO:0045087; P:innate immune response; TAS:Reactome. DR GO; GO:0002755; P:MyD88-dependent toll-like receptor signaling pathway; TAS:Reactome. DR GO; GO:0050729; P:positive regulation of inflammatory response; IEA:InterPro. DR GO; GO:0050707; P:regulation of cytokine secretion; IEA:InterPro. DR GO; GO:0034166; P:toll-like receptor 10 signaling pathway; TAS:Reactome. DR GO; GO:0034146; P:toll-like receptor 5 signaling pathway; TAS:Reactome. DR GO; GO:0002224; P:toll-like receptor signaling pathway; TAS:Reactome. DR Gene3D; 3.40.50.10140; -; 1. DR InterPro; IPR000483; Cys-rich_flank_reg_C. DR InterPro; IPR001611; Leu-rich_rpt. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR027182; TLR10. DR InterPro; IPR017241; Toll-like_receptor. DR PANTHER; PTHR24365:SF131; PTHR24365:SF131; 2. DR Pfam; PF00560; LRR_1; 1. DR Pfam; PF13855; LRR_8; 1. DR Pfam; PF01582; TIR; 1. DR PIRSF; PIRSF037595; Toll-like_receptor; 1. DR SMART; SM00082; LRRCT; 1. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS51450; LRR; 9. DR PROSITE; PS50104; TIR; 1. PE 1: Evidence at protein level; KW 3D-structure; Complete proteome; Glycoprotein; Immunity; KW Inflammatory response; Innate immunity; Leucine-rich repeat; Membrane; KW Polymorphism; Receptor; Reference proteome; Repeat; Signal; KW Transmembrane; Transmembrane helix. FT SIGNAL 1 19 {ECO:0000255}. FT CHAIN 20 811 Toll-like receptor 10. FT /FTId=PRO_0000034739. FT TOPO_DOM 20 576 Extracellular. {ECO:0000255}. FT TRANSMEM 577 597 Helical. {ECO:0000255}. FT TOPO_DOM 598 811 Cytoplasmic. {ECO:0000255}. FT REPEAT 24 46 LRR 1. FT REPEAT 49 70 LRR 2. FT REPEAT 73 94 LRR 3. FT REPEAT 97 118 LRR 4. FT REPEAT 119 139 LRR 5. FT REPEAT 143 166 LRR 6. FT REPEAT 296 321 LRR 7. FT REPEAT 325 348 LRR 8. FT REPEAT 349 368 LRR 9. FT REPEAT 373 394 LRR 10. FT REPEAT 398 419 LRR 11. FT REPEAT 422 442 LRR 12. FT REPEAT 444 465 LRR 13. FT REPEAT 467 488 LRR 14. FT REPEAT 489 509 LRR 15. FT DOMAIN 522 576 LRRCT. FT DOMAIN 632 778 TIR. {ECO:0000255|PROSITE- FT ProRule:PRU00204}. FT CARBOHYD 33 33 N-linked (GlcNAc...). {ECO:0000255}. FT CARBOHYD 36 36 N-linked (GlcNAc...). {ECO:0000255}. FT CARBOHYD 140 140 N-linked (GlcNAc...). {ECO:0000255}. FT CARBOHYD 189 189 N-linked (GlcNAc...). {ECO:0000255}. FT CARBOHYD 236 236 N-linked (GlcNAc...). {ECO:0000255}. FT CARBOHYD 278 278 N-linked (GlcNAc...). {ECO:0000255}. FT CARBOHYD 330 330 N-linked (GlcNAc...). {ECO:0000255}. FT CARBOHYD 416 416 N-linked (GlcNAc...). {ECO:0000255}. FT CARBOHYD 427 427 N-linked (GlcNAc...). {ECO:0000255}. FT VARIANT 163 163 A -> S (in dbSNP:rs11466649). FT /FTId=VAR_024669. FT VARIANT 167 167 L -> P (in dbSNP:rs11466650). FT /FTId=VAR_028125. FT VARIANT 241 241 N -> H (in dbSNP:rs11096957). FT {ECO:0000269|PubMed:14702039, FT ECO:0000269|PubMed:15489334}. FT /FTId=VAR_024670. FT VARIANT 298 298 V -> I (in dbSNP:rs11466651). FT /FTId=VAR_028126. FT VARIANT 326 326 M -> T (in dbSNP:rs11466653). FT /FTId=VAR_024671. FT VARIANT 369 369 I -> L (in dbSNP:rs11096955). FT {ECO:0000269|PubMed:14702039, FT ECO:0000269|PubMed:15489334}. FT /FTId=VAR_024672. FT VARIANT 381 381 G -> D (in dbSNP:rs11466655). FT {ECO:0000269|PubMed:19924287}. FT /FTId=VAR_024673. FT VARIANT 469 469 R -> G (in dbSNP:rs11466656). FT /FTId=VAR_028127. FT VARIANT 473 473 I -> T (in dbSNP:rs11466657). FT {ECO:0000269|PubMed:15489334}. FT /FTId=VAR_028128. FT VARIANT 525 525 R -> W (in dbSNP:rs11466658). FT /FTId=VAR_024674. FT VARIANT 736 736 Y -> C (in dbSNP:rs11466660). FT /FTId=VAR_028129. FT VARIANT 775 775 I -> F (in dbSNP:rs4129009). FT /FTId=VAR_059832. FT VARIANT 775 775 I -> L (in dbSNP:rs4129009). FT /FTId=VAR_028130. FT VARIANT 775 775 I -> V (in dbSNP:rs4129009). FT {ECO:0000269|PubMed:14702039, FT ECO:0000269|PubMed:15489334}. FT /FTId=VAR_059833. FT VARIANT 799 799 R -> L (in dbSNP:rs4129008). FT /FTId=VAR_059834. FT VARIANT 799 799 R -> P (in dbSNP:rs4129008). FT /FTId=VAR_059835. FT VARIANT 799 799 R -> Q (in dbSNP:rs4129008). FT /FTId=VAR_028131. FT CONFLICT 96 96 K -> R (in Ref. 5; BAF84715). FT {ECO:0000305}. FT CONFLICT 562 562 T -> I (in Ref. 1; AAK26744). FT {ECO:0000305}. FT STRAND 634 639 {ECO:0000244|PDB:2J67}. FT HELIX 642 644 {ECO:0000244|PDB:2J67}. FT HELIX 645 650 {ECO:0000244|PDB:2J67}. FT HELIX 652 656 {ECO:0000244|PDB:2J67}. FT HELIX 668 671 {ECO:0000244|PDB:2J67}. FT HELIX 678 687 {ECO:0000244|PDB:2J67}. FT STRAND 689 696 {ECO:0000244|PDB:2J67}. FT HELIX 698 703 {ECO:0000244|PDB:2J67}. FT HELIX 705 707 {ECO:0000244|PDB:2J67}. FT HELIX 709 712 {ECO:0000244|PDB:2J67}. FT TURN 717 719 {ECO:0000244|PDB:2J67}. FT STRAND 725 731 {ECO:0000244|PDB:2J67}. FT HELIX 735 737 {ECO:0000244|PDB:2J67}. FT HELIX 743 750 {ECO:0000244|PDB:2J67}. FT STRAND 754 756 {ECO:0000244|PDB:2J67}. FT HELIX 761 763 {ECO:0000244|PDB:2J67}. FT HELIX 764 775 {ECO:0000244|PDB:2J67}. SQ SEQUENCE 811 AA; 94564 MW; 6BFAAEF76886BFBA CRC64; MRLIRNIYIF CSIVMTAEGD APELPEEREL MTNCSNMSLR KVPADLTPAT TTLDLSYNLL FQLQSSDFHS VSKLRVLILC HNRIQQLDLK TFEFNKELRY LDLSNNRLKS VTWYLLAGLR YLDLSFNDFD TMPICEEAGN MSHLEILGLS GAKIQKSDFQ KIAHLHLNTV FLGFRTLPHY EEGSLPILNT TKLHIVLPMD TNFWVLLRDG IKTSKILEMT NIDGKSQFVS YEMQRNLSLE NAKTSVLLLN KVDLLWDDLF LILQFVWHTS VEHFQIRNVT FGGKAYLDHN SFDYSNTVMR TIKLEHVHFR VFYIQQDKIY LLLTKMDIEN LTISNAQMPH MLFPNYPTKF QYLNFANNIL TDELFKRTIQ LPHLKTLILN GNKLETLSLV SCFANNTPLE HLDLSQNLLQ HKNDENCSWP ETVVNMNLSY NKLSDSVFRC LPKSIQILDL NNNQIQTVPK ETIHLMALRE LNIAFNFLTD LPGCSHFSRL SVLNIEMNFI LSPSLDFVQS CQEVKTLNAG RNPFRCTCEL KNFIQLETYS EVMMVGWSDS YTCEYPLNLR GTRLKDVHLH ELSCNTALLI VTIVVIMLVL GLAVAFCCLH FDLPWYLRML GQCTQTWHRV RKTTQEQLKR NVRFHAFISY SEHDSLWVKN ELIPNLEKED GSILICLYES YFDPGKSISE NIVSFIEKSY KSIFVLSPNF VQNEWCHYEF YFAHHNLFHE NSDHIILILL EPIPFYCIPT RYHKLKALLE KKAYLEWPKD RRKCGLFWAN LRAAINVNVL ATREMYELQT FTELNEESRG STISLMRTDC L //