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Reviewed, UniProtKB/Swiss-Prot Q9BXR5 (TLR10_HUMAN)

Last modified February 9, 2010. Version 88. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (7) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Toll-like receptor 10
Alternative name(s):
    CD_antigen=CD290
Gene names
Name: TLR10
ORF Names: UNQ315/PRO358
OrganismHomo sapiens (Human) [Complete proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

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Protein attributes

Sequence length811 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level.

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General annotation (Comments)

Function

Participates in the innate immune response to microbial agents. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response By similarity.

Subunit structure

Binds MYD88 via their respective TIR domains By similarity. Homodimer Potential. Ref.7

Subcellular location

Membrane; Single-pass type I membrane protein By similarity.

Tissue specificity

Highly expressed in spleen, lymph node, thymus, tonsil and at lower levels in lung. Highly expressed in promyelocytic HL-60 cells and in B-cell lines.

Sequence similarities

Belongs to the Toll-like receptor family.

Contains 15 LRR (leucine-rich) repeats.

Contains 1 TIR domain.

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Ontologies

Keywords
   Biological processImmune response
Inflammatory response
Innate immunity
   Cellular componentMembrane
   Coding sequence diversityPolymorphism
   DomainLeucine-rich repeat
Repeat
Signal
Transmembrane
   Molecular functionReceptor
   PTMGlycoprotein
   Technical term3D-structure
Complete proteome
Gene Ontology (GO)
   Biological processI-kappaB kinase/NF-kappaB cascade

Inferred from Experiment. Source: Reactome

inflammatory response

Inferred from electronic annotation. Source: UniProtKB-KW

innate immune response

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentintegral to membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

plasma membrane

Inferred from Experiment. Source: Reactome

   Molecular functionprotein binding

Inferred from electronic annotation. Source: InterPro

transmembrane receptor activity Ref.1

Traceable author statement. Source: UniProtKB

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1919 Potential
Chain20 – 811792Toll-like receptor 10
PRO_0000034739

Regions

Topological domain20 – 576557Extracellular Potential
Transmembrane577 – 59721 Potential
Topological domain598 – 811214Cytoplasmic Potential
Repeat24 – 4623LRR 1
Repeat47 – 7024LRR 2
Repeat71 – 9424LRR 3
Repeat96 – 11621LRR 4
Repeat117 – 13923LRR 5
Repeat141 – 16424LRR 6
Repeat296 – 32126LRR 7
Repeat325 – 34824LRR 8
Repeat350 – 36718LRR 9
Repeat371 – 39525LRR 10
Repeat397 – 41923LRR 11
Repeat421 – 44020LRR 12
Repeat442 – 46524LRR 13
Repeat467 – 48923LRR 14
Repeat556 – 58126LRR 15
Domain632 – 778147TIR

Amino acid modifications

Glycosylation331N-linked (GlcNAc...) Potential
Glycosylation361N-linked (GlcNAc...) Potential
Glycosylation1401N-linked (GlcNAc...) Potential
Glycosylation1891N-linked (GlcNAc...) Potential
Glycosylation2361N-linked (GlcNAc...) Potential
Glycosylation2781N-linked (GlcNAc...) Potential
Glycosylation3301N-linked (GlcNAc...) Potential
Glycosylation4161N-linked (GlcNAc...) Potential
Glycosylation4271N-linked (GlcNAc...) Potential

Natural variations

Natural variant1631A → S: dbSNP rs11466649.
VAR_024669
Natural variant1671L → P: dbSNP rs11466650.
VAR_028125
Natural variant2411N → H: dbSNP rs11096957. Ref.4 Ref.6
VAR_024670
Natural variant2981V → I: dbSNP rs11466651.
VAR_028126
Natural variant3261M → T: dbSNP rs11466653.
VAR_024671
Natural variant3691I → L: dbSNP rs11096955. Ref.4 Ref.6
VAR_024672
Natural variant3811G → D: dbSNP rs11466655.
VAR_024673
Natural variant4691R → G: dbSNP rs11466656.
VAR_028127
Natural variant4731I → T: dbSNP rs11466657. Ref.6
VAR_028128
Natural variant5251R → W: dbSNP rs11466658.
VAR_024674
Natural variant7361Y → C: dbSNP rs11466660.
VAR_028129
Natural variant7751I → F: dbSNP rs4129009.
VAR_059832
Natural variant7751I → L: dbSNP rs4129009.
VAR_028130
Natural variant7751I → V: dbSNP rs4129009. Ref.4 Ref.6
VAR_059833
Natural variant7991R → L: dbSNP rs4129008.
VAR_059834
Natural variant7991R → P: dbSNP rs4129008.
VAR_059835
Natural variant7991R → Q: dbSNP rs4129008.
VAR_028131

Experimental info

Sequence conflict961K → R in BAF84715. Ref.4
Sequence conflict5621T → I in AAK26744. Ref.1

Secondary structure

1 ............................... 811
Helix Strand Turn

Details...

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Sequences

Sequence LengthMass (Da)Tools
Q9BXR5-1 [UniParc].

Last modified October 17, 2006. Version 2.
Checksum: 6BFAAEF76886BFBA

FASTA81194,564
        10         20         30         40         50         60 
MRLIRNIYIF CSIVMTAEGD APELPEEREL MTNCSNMSLR KVPADLTPAT TTLDLSYNLL 

        70         80         90        100        110        120 
FQLQSSDFHS VSKLRVLILC HNRIQQLDLK TFEFNKELRY LDLSNNRLKS VTWYLLAGLR 

       130        140        150        160        170        180 
YLDLSFNDFD TMPICEEAGN MSHLEILGLS GAKIQKSDFQ KIAHLHLNTV FLGFRTLPHY 

       190        200        210        220        230        240 
EEGSLPILNT TKLHIVLPMD TNFWVLLRDG IKTSKILEMT NIDGKSQFVS YEMQRNLSLE 

       250        260        270        280        290        300 
NAKTSVLLLN KVDLLWDDLF LILQFVWHTS VEHFQIRNVT FGGKAYLDHN SFDYSNTVMR 

       310        320        330        340        350        360 
TIKLEHVHFR VFYIQQDKIY LLLTKMDIEN LTISNAQMPH MLFPNYPTKF QYLNFANNIL 

       370        380        390        400        410        420 
TDELFKRTIQ LPHLKTLILN GNKLETLSLV SCFANNTPLE HLDLSQNLLQ HKNDENCSWP 

       430        440        450        460        470        480 
ETVVNMNLSY NKLSDSVFRC LPKSIQILDL NNNQIQTVPK ETIHLMALRE LNIAFNFLTD 

       490        500        510        520        530        540 
LPGCSHFSRL SVLNIEMNFI LSPSLDFVQS CQEVKTLNAG RNPFRCTCEL KNFIQLETYS 

       550        560        570        580        590        600 
EVMMVGWSDS YTCEYPLNLR GTRLKDVHLH ELSCNTALLI VTIVVIMLVL GLAVAFCCLH 

       610        620        630        640        650        660 
FDLPWYLRML GQCTQTWHRV RKTTQEQLKR NVRFHAFISY SEHDSLWVKN ELIPNLEKED 

       670        680        690        700        710        720 
GSILICLYES YFDPGKSISE NIVSFIEKSY KSIFVLSPNF VQNEWCHYEF YFAHHNLFHE 

       730        740        750        760        770        780 
NSDHIILILL EPIPFYCIPT RYHKLKALLE KKAYLEWPKD RRKCGLFWAN LRAAINVNVL 

       790        800        810 
ATREMYELQT FTELNEESRG STISLMRTDC L

« Hide

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References

« Hide 'large scale' references
[1]"Identification of hTLR10: a novel human Toll-like receptor preferentially expressed in immune cells."
Chuang T.-H., Ulevitch R.J.
Biochim. Biophys. Acta 1518:157-161(2001) [PubMed: 11267672] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Spleen.
[2]"Natural selection in the TLR-related genes in the course of primate evolution."
Nakajima T., Ohtani H., Satta Y., Uno Y., Akari H., Ishida T., Kimura A.
Immunogenetics 60:727-735(2008) [PubMed: 18810425] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. expand/collapse author list , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.
Genome Res. 13:2265-2270(2003) [PubMed: 12975309] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS HIS-241; LEU-369 AND VAL-775.
Tissue: Spleen.
[5]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS HIS-241; LEU-369; THR-473 AND VAL-775.
Tissue: Lymph.
[7]"The crystal structure of the human toll-like receptor 10 cytoplasmic domain reveals a putative signaling dimer."
Nyman T., Stenmark P., Flodin S., Johansson I., Hammarstrom M., Nordlund P.
J. Biol. Chem. 283:11861-11865(2008) [PubMed: 18332149] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) OF 622-776, SUBUNIT.
+Additional computationally mapped references.

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AF296673 mRNA. Translation: AAK26744.1.
AB445680 mRNA. Translation: BAG55077.1.
AY358300 mRNA. Translation: AAQ88667.1.
AK292026 mRNA. Translation: BAF84715.1.
CH471069 Genomic DNA. Translation: EAW92897.1.
BC089406 mRNA. Translation: AAH89406.1.
BC109111 mRNA. Translation: AAI09112.1.
BC109112 mRNA. Translation: AAI09113.1.
IPIIPI00008887.
RefSeqNP_001017388.1.
NP_112218.2.
UniGeneHs.120551

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2J67X-ray2.20A/B622-776[»]
SMRQ9BXR5. Positions 29-535, 31-672.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ9BXR5.

Proteomic databases

PRIDEQ9BXR5.

Genome annotation databases

EnsemblENST00000308973; ENSP00000308925; ENSG00000174123; Homo sapiens. [Genome view]
ENST00000361424; ENSP00000354459; ENSG00000174123; Homo sapiens. [Genome view]
GeneID81793.
KEGGhsa:81793.
UCSCuc003gti.1. human.

Organism-specific databases

CTD81793.
GeneCardsGC04M038450.
H-InvDBHIX0031388.
HGNCHGNC:15634. TLR10.
MIM606270. gene.
PharmGKBPA38011.
GenAtlasSearch...

Phylogenomic databases

HOVERGENQ9BXR5.
InParanoidQ9BXR5.
OMANTTKLHI.
OrthoDBEOG9SJ80S.
PhylomeDBQ9BXR5.

Enzyme and pathway databases

ReactomeREACT_6900. Signaling in Immune system.

Gene expression databases

ArrayExpressQ9BXR5.
BgeeQ9BXR5.
CleanExHS_TLR10.
GenevestigatorQ9BXR5.
GermOnlineENSG00000174123. Homo sapiens.

Family and domain databases

InterProIPR000483. Cys-rich_flank_reg_C.
IPR001611. Leu-rich_rpt.
IPR000157. Toll-Interleukin_rcpt.
IPR017241. Toll-like_receptor.
[Graphical view]
PfamPF00560. LRR_1. 2 hits.
PF01582. TIR. 1 hit.
[Graphical view]
PIRSFPIRSF037595. Toll-like_receptor. 1 hit.
SMARTSM00082. LRRCT. 1 hit.
SM00255. TIR. 1 hit.
[Graphical view]
PROSITEPS51450. LRR. 9 hits.
PS50104. TIR. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio72104.
SOURCESearch...

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Entry information

Entry nameTLR10_HUMAN
AccessionPrimary (citable) accession number: Q9BXR5
Secondary accession number(s): A8K7L1 expand/collapse secondary AC list , B3Y668, Q32MI7, Q32MI8, Q5FWG4, Q6UXL3
Entry history
Integrated into UniProtKB/Swiss-Prot: January 31, 2002
Last sequence update: October 17, 2006
Last modified: February 9, 2010
This is version 88 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents