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Protein

Toll-like receptor 10

Gene

TLR10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Participates in the innate immune response to microbial agents. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity).By similarity

GO - Molecular functioni

  • transmembrane signaling receptor activity Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Immunity, Inflammatory response, Innate immunity

Enzyme and pathway databases

ReactomeiREACT_27215. MyD88 cascade initiated on plasma membrane.
REACT_355387. IRAK4 deficiency (TLR5).
REACT_9027. Toll Like Receptor 10 (TLR10) Cascade.

Names & Taxonomyi

Protein namesi
Recommended name:
Toll-like receptor 10
Alternative name(s):
CD_antigen: CD290
Gene namesi
Name:TLR10
ORF Names:UNQ315/PRO358
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:15634. TLR10.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini20 – 576557ExtracellularSequence AnalysisAdd
BLAST
Transmembranei577 – 59721HelicalSequence AnalysisAdd
BLAST
Topological domaini598 – 811214CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • membrane Source: UniProtKB
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38011.

Polymorphism and mutation databases

BioMutaiTLR10.
DMDMi116242819.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Sequence AnalysisAdd
BLAST
Chaini20 – 811792Toll-like receptor 10PRO_0000034739Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi33 – 331N-linked (GlcNAc...)Sequence Analysis
Glycosylationi36 – 361N-linked (GlcNAc...)Sequence Analysis
Glycosylationi140 – 1401N-linked (GlcNAc...)Sequence Analysis
Glycosylationi189 – 1891N-linked (GlcNAc...)Sequence Analysis
Glycosylationi236 – 2361N-linked (GlcNAc...)Sequence Analysis
Glycosylationi278 – 2781N-linked (GlcNAc...)Sequence Analysis
Glycosylationi330 – 3301N-linked (GlcNAc...)Sequence Analysis
Glycosylationi416 – 4161N-linked (GlcNAc...)Sequence Analysis
Glycosylationi427 – 4271N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9BXR5.
PRIDEiQ9BXR5.

PTM databases

PhosphoSiteiQ9BXR5.

Expressioni

Tissue specificityi

Highly expressed in spleen, lymph node, thymus, tonsil and at lower levels in lung. Highly expressed in promyelocytic HL-60 cells and in B-cell lines.

Gene expression databases

BgeeiQ9BXR5.
CleanExiHS_TLR10.
ExpressionAtlasiQ9BXR5. baseline and differential.
GenevestigatoriQ9BXR5.

Interactioni

Subunit structurei

Binds MYD88 via their respective TIR domains (By similarity). Homodimer (Potential).By similarityCurated

Protein-protein interaction databases

STRINGi9606.ENSP00000308925.

Structurei

Secondary structure

1
811
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi634 – 6396Combined sources
Helixi642 – 6443Combined sources
Helixi645 – 6506Combined sources
Helixi652 – 6565Combined sources
Helixi668 – 6714Combined sources
Helixi678 – 68710Combined sources
Beta strandi689 – 6968Combined sources
Helixi698 – 7036Combined sources
Helixi705 – 7073Combined sources
Helixi709 – 7124Combined sources
Beta strandi725 – 7317Combined sources
Helixi735 – 7373Combined sources
Helixi743 – 7508Combined sources
Beta strandi754 – 7563Combined sources
Helixi761 – 7633Combined sources
Helixi764 – 77512Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2J67X-ray2.20A/B622-776[»]
ProteinModelPortaliQ9BXR5.
SMRiQ9BXR5. Positions 2-569, 628-776.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9BXR5.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati24 – 4623LRR 1Add
BLAST
Repeati49 – 7022LRR 2Add
BLAST
Repeati73 – 9422LRR 3Add
BLAST
Repeati97 – 11822LRR 4Add
BLAST
Repeati119 – 13921LRR 5Add
BLAST
Repeati143 – 16624LRR 6Add
BLAST
Repeati296 – 32126LRR 7Add
BLAST
Repeati325 – 34824LRR 8Add
BLAST
Repeati349 – 36820LRR 9Add
BLAST
Repeati373 – 39422LRR 10Add
BLAST
Repeati398 – 41922LRR 11Add
BLAST
Repeati422 – 44221LRR 12Add
BLAST
Repeati444 – 46522LRR 13Add
BLAST
Repeati467 – 48822LRR 14Add
BLAST
Repeati489 – 50921LRR 15Add
BLAST
Domaini522 – 57655LRRCTAdd
BLAST
Domaini632 – 778147TIRPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the Toll-like receptor family.Curated
Contains 15 LRR (leucine-rich) repeats.Curated
Contains 1 LRRCT domain.Curated
Contains 1 TIR domain.PROSITE-ProRule annotation

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG272762.
GeneTreeiENSGT00760000119006.
HOGENOMiHOG000008676.
HOVERGENiHBG023180.
InParanoidiQ9BXR5.
KOiK10171.
OMAiAYLEWPK.
OrthoDBiEOG7GN2M5.
PhylomeDBiQ9BXR5.
TreeFamiTF351113.

Family and domain databases

Gene3Di3.40.50.10140. 1 hit.
InterProiIPR000483. Cys-rich_flank_reg_C.
IPR001611. Leu-rich_rpt.
IPR000157. TIR_dom.
IPR027182. TLR10.
IPR017241. Toll-like_receptor.
[Graphical view]
PANTHERiPTHR24365:SF131. PTHR24365:SF131. 1 hit.
PfamiPF00560. LRR_1. 1 hit.
PF13504. LRR_7. 1 hit.
PF13855. LRR_8. 1 hit.
PF01582. TIR. 1 hit.
[Graphical view]
PIRSFiPIRSF037595. Toll-like_receptor. 1 hit.
SMARTiSM00082. LRRCT. 1 hit.
SM00255. TIR. 1 hit.
[Graphical view]
SUPFAMiSSF52200. SSF52200. 1 hit.
PROSITEiPS51450. LRR. 9 hits.
PS50104. TIR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9BXR5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRLIRNIYIF CSIVMTAEGD APELPEEREL MTNCSNMSLR KVPADLTPAT
60 70 80 90 100
TTLDLSYNLL FQLQSSDFHS VSKLRVLILC HNRIQQLDLK TFEFNKELRY
110 120 130 140 150
LDLSNNRLKS VTWYLLAGLR YLDLSFNDFD TMPICEEAGN MSHLEILGLS
160 170 180 190 200
GAKIQKSDFQ KIAHLHLNTV FLGFRTLPHY EEGSLPILNT TKLHIVLPMD
210 220 230 240 250
TNFWVLLRDG IKTSKILEMT NIDGKSQFVS YEMQRNLSLE NAKTSVLLLN
260 270 280 290 300
KVDLLWDDLF LILQFVWHTS VEHFQIRNVT FGGKAYLDHN SFDYSNTVMR
310 320 330 340 350
TIKLEHVHFR VFYIQQDKIY LLLTKMDIEN LTISNAQMPH MLFPNYPTKF
360 370 380 390 400
QYLNFANNIL TDELFKRTIQ LPHLKTLILN GNKLETLSLV SCFANNTPLE
410 420 430 440 450
HLDLSQNLLQ HKNDENCSWP ETVVNMNLSY NKLSDSVFRC LPKSIQILDL
460 470 480 490 500
NNNQIQTVPK ETIHLMALRE LNIAFNFLTD LPGCSHFSRL SVLNIEMNFI
510 520 530 540 550
LSPSLDFVQS CQEVKTLNAG RNPFRCTCEL KNFIQLETYS EVMMVGWSDS
560 570 580 590 600
YTCEYPLNLR GTRLKDVHLH ELSCNTALLI VTIVVIMLVL GLAVAFCCLH
610 620 630 640 650
FDLPWYLRML GQCTQTWHRV RKTTQEQLKR NVRFHAFISY SEHDSLWVKN
660 670 680 690 700
ELIPNLEKED GSILICLYES YFDPGKSISE NIVSFIEKSY KSIFVLSPNF
710 720 730 740 750
VQNEWCHYEF YFAHHNLFHE NSDHIILILL EPIPFYCIPT RYHKLKALLE
760 770 780 790 800
KKAYLEWPKD RRKCGLFWAN LRAAINVNVL ATREMYELQT FTELNEESRG
810
STISLMRTDC L
Length:811
Mass (Da):94,564
Last modified:October 17, 2006 - v2
Checksum:i6BFAAEF76886BFBA
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti96 – 961K → R in BAF84715 (PubMed:14702039).Curated
Sequence conflicti562 – 5621T → I in AAK26744 (PubMed:11267672).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti163 – 1631A → S.
Corresponds to variant rs11466649 [ dbSNP | Ensembl ].
VAR_024669
Natural varianti167 – 1671L → P.
Corresponds to variant rs11466650 [ dbSNP | Ensembl ].
VAR_028125
Natural varianti241 – 2411N → H.2 Publications
Corresponds to variant rs11096957 [ dbSNP | Ensembl ].
VAR_024670
Natural varianti298 – 2981V → I.
Corresponds to variant rs11466651 [ dbSNP | Ensembl ].
VAR_028126
Natural varianti326 – 3261M → T.
Corresponds to variant rs11466653 [ dbSNP | Ensembl ].
VAR_024671
Natural varianti369 – 3691I → L.2 Publications
Corresponds to variant rs11096955 [ dbSNP | Ensembl ].
VAR_024672
Natural varianti381 – 3811G → D.1 Publication
Corresponds to variant rs11466655 [ dbSNP | Ensembl ].
VAR_024673
Natural varianti469 – 4691R → G.
Corresponds to variant rs11466656 [ dbSNP | Ensembl ].
VAR_028127
Natural varianti473 – 4731I → T.1 Publication
Corresponds to variant rs11466657 [ dbSNP | Ensembl ].
VAR_028128
Natural varianti525 – 5251R → W.
Corresponds to variant rs11466658 [ dbSNP | Ensembl ].
VAR_024674
Natural varianti736 – 7361Y → C.
Corresponds to variant rs11466660 [ dbSNP | Ensembl ].
VAR_028129
Natural varianti775 – 7751I → F.
Corresponds to variant rs4129009 [ dbSNP | Ensembl ].
VAR_059832
Natural varianti775 – 7751I → L.
Corresponds to variant rs4129009 [ dbSNP | Ensembl ].
VAR_028130
Natural varianti775 – 7751I → V.2 Publications
Corresponds to variant rs4129009 [ dbSNP | Ensembl ].
VAR_059833
Natural varianti799 – 7991R → L.
Corresponds to variant rs4129008 [ dbSNP | Ensembl ].
VAR_059834
Natural varianti799 – 7991R → P.
Corresponds to variant rs4129008 [ dbSNP | Ensembl ].
VAR_059835
Natural varianti799 – 7991R → Q.
Corresponds to variant rs4129008 [ dbSNP | Ensembl ].
VAR_028131

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF296673 mRNA. Translation: AAK26744.1.
AB445680 mRNA. Translation: BAG55077.1.
DQ011504 mRNA. Translation: AAY78479.1.
DQ011505 mRNA. Translation: AAY78480.1.
AY358300 mRNA. Translation: AAQ88667.1.
AK292026 mRNA. Translation: BAF84715.1.
CH471069 Genomic DNA. Translation: EAW92897.1.
BC089406 mRNA. Translation: AAH89406.1.
BC109111 mRNA. Translation: AAI09112.1.
BC109112 mRNA. Translation: AAI09113.1.
CCDSiCCDS3445.1.
RefSeqiNP_001017388.1. NM_001017388.2.
NP_001182035.1. NM_001195106.1.
NP_001182036.1. NM_001195107.1.
NP_001182037.1. NM_001195108.1.
NP_112218.2. NM_030956.3.
UniGeneiHs.120551.
Hs.730896.

Genome annotation databases

EnsembliENST00000308973; ENSP00000308925; ENSG00000174123.
ENST00000361424; ENSP00000354459; ENSG00000174123.
ENST00000506111; ENSP00000421483; ENSG00000174123.
ENST00000508334; ENSP00000424923; ENSG00000174123.
ENST00000613579; ENSP00000478206; ENSG00000174123.
ENST00000622002; ENSP00000478985; ENSG00000174123.
GeneIDi81793.
KEGGihsa:81793.
UCSCiuc003gti.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF296673 mRNA. Translation: AAK26744.1.
AB445680 mRNA. Translation: BAG55077.1.
DQ011504 mRNA. Translation: AAY78479.1.
DQ011505 mRNA. Translation: AAY78480.1.
AY358300 mRNA. Translation: AAQ88667.1.
AK292026 mRNA. Translation: BAF84715.1.
CH471069 Genomic DNA. Translation: EAW92897.1.
BC089406 mRNA. Translation: AAH89406.1.
BC109111 mRNA. Translation: AAI09112.1.
BC109112 mRNA. Translation: AAI09113.1.
CCDSiCCDS3445.1.
RefSeqiNP_001017388.1. NM_001017388.2.
NP_001182035.1. NM_001195106.1.
NP_001182036.1. NM_001195107.1.
NP_001182037.1. NM_001195108.1.
NP_112218.2. NM_030956.3.
UniGeneiHs.120551.
Hs.730896.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2J67X-ray2.20A/B622-776[»]
ProteinModelPortaliQ9BXR5.
SMRiQ9BXR5. Positions 2-569, 628-776.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000308925.

PTM databases

PhosphoSiteiQ9BXR5.

Polymorphism and mutation databases

BioMutaiTLR10.
DMDMi116242819.

Proteomic databases

PaxDbiQ9BXR5.
PRIDEiQ9BXR5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000308973; ENSP00000308925; ENSG00000174123.
ENST00000361424; ENSP00000354459; ENSG00000174123.
ENST00000506111; ENSP00000421483; ENSG00000174123.
ENST00000508334; ENSP00000424923; ENSG00000174123.
ENST00000613579; ENSP00000478206; ENSG00000174123.
ENST00000622002; ENSP00000478985; ENSG00000174123.
GeneIDi81793.
KEGGihsa:81793.
UCSCiuc003gti.3. human.

Organism-specific databases

CTDi81793.
GeneCardsiGC04M038773.
HGNCiHGNC:15634. TLR10.
MIMi606270. gene.
neXtProtiNX_Q9BXR5.
PharmGKBiPA38011.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG272762.
GeneTreeiENSGT00760000119006.
HOGENOMiHOG000008676.
HOVERGENiHBG023180.
InParanoidiQ9BXR5.
KOiK10171.
OMAiAYLEWPK.
OrthoDBiEOG7GN2M5.
PhylomeDBiQ9BXR5.
TreeFamiTF351113.

Enzyme and pathway databases

ReactomeiREACT_27215. MyD88 cascade initiated on plasma membrane.
REACT_355387. IRAK4 deficiency (TLR5).
REACT_9027. Toll Like Receptor 10 (TLR10) Cascade.

Miscellaneous databases

EvolutionaryTraceiQ9BXR5.
GeneWikiiTLR10.
GenomeRNAii81793.
NextBioi35489020.
PROiQ9BXR5.
SOURCEiSearch...

Gene expression databases

BgeeiQ9BXR5.
CleanExiHS_TLR10.
ExpressionAtlasiQ9BXR5. baseline and differential.
GenevestigatoriQ9BXR5.

Family and domain databases

Gene3Di3.40.50.10140. 1 hit.
InterProiIPR000483. Cys-rich_flank_reg_C.
IPR001611. Leu-rich_rpt.
IPR000157. TIR_dom.
IPR027182. TLR10.
IPR017241. Toll-like_receptor.
[Graphical view]
PANTHERiPTHR24365:SF131. PTHR24365:SF131. 1 hit.
PfamiPF00560. LRR_1. 1 hit.
PF13504. LRR_7. 1 hit.
PF13855. LRR_8. 1 hit.
PF01582. TIR. 1 hit.
[Graphical view]
PIRSFiPIRSF037595. Toll-like_receptor. 1 hit.
SMARTiSM00082. LRRCT. 1 hit.
SM00255. TIR. 1 hit.
[Graphical view]
SUPFAMiSSF52200. SSF52200. 1 hit.
PROSITEiPS51450. LRR. 9 hits.
PS50104. TIR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of hTLR10: a novel human Toll-like receptor preferentially expressed in immune cells."
    Chuang T.-H., Ulevitch R.J.
    Biochim. Biophys. Acta 1518:157-161(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Spleen.
  2. "Natural selection in the TLR-related genes in the course of primate evolution."
    Nakajima T., Ohtani H., Satta Y., Uno Y., Akari H., Ishida T., Kimura A.
    Immunogenetics 60:727-735(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "The heterogeneous allelic repertoire of human Toll-Like receptor (TLR) genes."
    Georgel P., Macquin C., Bahram S.
    PLoS ONE 4:E7803-E7803(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT ASP-381.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS HIS-241; LEU-369 AND VAL-775.
    Tissue: Spleen.
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS HIS-241; LEU-369; THR-473 AND VAL-775.
    Tissue: Lymph.
  8. "The crystal structure of the human toll-like receptor 10 cytoplasmic domain reveals a putative signaling dimer."
    Nyman T., Stenmark P., Flodin S., Johansson I., Hammarstrom M., Nordlund P.
    J. Biol. Chem. 283:11861-11865(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) OF 622-776, SUBUNIT.

Entry informationi

Entry nameiTLR10_HUMAN
AccessioniPrimary (citable) accession number: Q9BXR5
Secondary accession number(s): A8K7L1
, B3Y668, D1CS21, D1CS22, Q32MI7, Q32MI8, Q5FWG4, Q6UXL3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 31, 2002
Last sequence update: October 17, 2006
Last modified: May 27, 2015
This is version 137 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.