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Q9BXR5

- TLR10_HUMAN

UniProt

Q9BXR5 - TLR10_HUMAN

Protein

Toll-like receptor 10

Gene

TLR10

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 132 (01 Oct 2014)
      Sequence version 2 (17 Oct 2006)
      Previous versions | rss
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    Functioni

    Participates in the innate immune response to microbial agents. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response By similarity.By similarity

    GO - Molecular functioni

    1. transmembrane signaling receptor activity Source: UniProtKB

    GO - Biological processi

    1. immune response Source: UniProtKB
    2. inflammatory response Source: UniProtKB-KW
    3. innate immune response Source: Reactome
    4. MyD88-dependent toll-like receptor signaling pathway Source: Reactome
    5. positive regulation of inflammatory response Source: InterPro
    6. regulation of cytokine secretion Source: InterPro
    7. toll-like receptor 10 signaling pathway Source: Reactome
    8. toll-like receptor 5 signaling pathway Source: Reactome
    9. toll-like receptor signaling pathway Source: Reactome

    Keywords - Molecular functioni

    Receptor

    Keywords - Biological processi

    Immunity, Inflammatory response, Innate immunity

    Enzyme and pathway databases

    ReactomeiREACT_27215. MyD88 cascade initiated on plasma membrane.
    REACT_9027. Toll Like Receptor 10 (TLR10) Cascade.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Toll-like receptor 10
    Alternative name(s):
    CD_antigen: CD290
    Gene namesi
    Name:TLR10
    ORF Names:UNQ315/PRO358
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 4

    Organism-specific databases

    HGNCiHGNC:15634. TLR10.

    Subcellular locationi

    Membrane By similarity; Single-pass type I membrane protein By similarity

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. membrane Source: UniProtKB
    3. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA38011.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1919Sequence AnalysisAdd
    BLAST
    Chaini20 – 811792Toll-like receptor 10PRO_0000034739Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi33 – 331N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi36 – 361N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi140 – 1401N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi189 – 1891N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi236 – 2361N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi278 – 2781N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi330 – 3301N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi416 – 4161N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi427 – 4271N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ9BXR5.
    PRIDEiQ9BXR5.

    PTM databases

    PhosphoSiteiQ9BXR5.

    Expressioni

    Tissue specificityi

    Highly expressed in spleen, lymph node, thymus, tonsil and at lower levels in lung. Highly expressed in promyelocytic HL-60 cells and in B-cell lines.

    Gene expression databases

    ArrayExpressiQ9BXR5.
    BgeeiQ9BXR5.
    CleanExiHS_TLR10.
    GenevestigatoriQ9BXR5.

    Interactioni

    Subunit structurei

    Binds MYD88 via their respective TIR domains By similarity. Homodimer Potential.By similarityCurated

    Protein-protein interaction databases

    STRINGi9606.ENSP00000308925.

    Structurei

    Secondary structure

    1
    811
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi634 – 6396
    Helixi642 – 6443
    Helixi645 – 6506
    Helixi652 – 6565
    Helixi668 – 6714
    Helixi678 – 68710
    Beta strandi689 – 6968
    Helixi698 – 7036
    Helixi705 – 7073
    Helixi709 – 7124
    Beta strandi725 – 7317
    Helixi735 – 7373
    Helixi743 – 7508
    Beta strandi754 – 7563
    Helixi761 – 7633
    Helixi764 – 77512

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2J67X-ray2.20A/B622-776[»]
    ProteinModelPortaliQ9BXR5.
    SMRiQ9BXR5. Positions 1-569, 628-776.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ9BXR5.

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini20 – 576557ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini598 – 811214CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei577 – 59721HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati24 – 4623LRR 1Add
    BLAST
    Repeati49 – 7022LRR 2Add
    BLAST
    Repeati73 – 9422LRR 3Add
    BLAST
    Repeati97 – 11822LRR 4Add
    BLAST
    Repeati119 – 13921LRR 5Add
    BLAST
    Repeati143 – 16624LRR 6Add
    BLAST
    Repeati296 – 32126LRR 7Add
    BLAST
    Repeati325 – 34824LRR 8Add
    BLAST
    Repeati349 – 36820LRR 9Add
    BLAST
    Repeati373 – 39422LRR 10Add
    BLAST
    Repeati398 – 41922LRR 11Add
    BLAST
    Repeati422 – 44221LRR 12Add
    BLAST
    Repeati444 – 46522LRR 13Add
    BLAST
    Repeati467 – 48822LRR 14Add
    BLAST
    Repeati489 – 50921LRR 15Add
    BLAST
    Domaini522 – 57655LRRCTAdd
    BLAST
    Domaini632 – 778147TIRPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the Toll-like receptor family.Curated
    Contains 15 LRR (leucine-rich) repeats.Curated
    Contains 1 LRRCT domain.Curated
    Contains 1 TIR domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG272762.
    HOGENOMiHOG000008676.
    HOVERGENiHBG023180.
    InParanoidiQ9BXR5.
    KOiK10171.
    OMAiTSKILEM.
    OrthoDBiEOG7GN2M5.
    PhylomeDBiQ9BXR5.
    TreeFamiTF351113.

    Family and domain databases

    Gene3Di3.40.50.10140. 1 hit.
    InterProiIPR000483. Cys-rich_flank_reg_C.
    IPR001611. Leu-rich_rpt.
    IPR000157. TIR_dom.
    IPR027182. TLR10.
    IPR017241. Toll-like_receptor.
    [Graphical view]
    PANTHERiPTHR24365:SF131. PTHR24365:SF131. 1 hit.
    PfamiPF00560. LRR_1. 1 hit.
    PF13504. LRR_7. 1 hit.
    PF13855. LRR_8. 1 hit.
    PF01582. TIR. 1 hit.
    [Graphical view]
    PIRSFiPIRSF037595. Toll-like_receptor. 1 hit.
    SMARTiSM00082. LRRCT. 1 hit.
    SM00255. TIR. 1 hit.
    [Graphical view]
    SUPFAMiSSF52200. SSF52200. 1 hit.
    PROSITEiPS51450. LRR. 9 hits.
    PS50104. TIR. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9BXR5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRLIRNIYIF CSIVMTAEGD APELPEEREL MTNCSNMSLR KVPADLTPAT    50
    TTLDLSYNLL FQLQSSDFHS VSKLRVLILC HNRIQQLDLK TFEFNKELRY 100
    LDLSNNRLKS VTWYLLAGLR YLDLSFNDFD TMPICEEAGN MSHLEILGLS 150
    GAKIQKSDFQ KIAHLHLNTV FLGFRTLPHY EEGSLPILNT TKLHIVLPMD 200
    TNFWVLLRDG IKTSKILEMT NIDGKSQFVS YEMQRNLSLE NAKTSVLLLN 250
    KVDLLWDDLF LILQFVWHTS VEHFQIRNVT FGGKAYLDHN SFDYSNTVMR 300
    TIKLEHVHFR VFYIQQDKIY LLLTKMDIEN LTISNAQMPH MLFPNYPTKF 350
    QYLNFANNIL TDELFKRTIQ LPHLKTLILN GNKLETLSLV SCFANNTPLE 400
    HLDLSQNLLQ HKNDENCSWP ETVVNMNLSY NKLSDSVFRC LPKSIQILDL 450
    NNNQIQTVPK ETIHLMALRE LNIAFNFLTD LPGCSHFSRL SVLNIEMNFI 500
    LSPSLDFVQS CQEVKTLNAG RNPFRCTCEL KNFIQLETYS EVMMVGWSDS 550
    YTCEYPLNLR GTRLKDVHLH ELSCNTALLI VTIVVIMLVL GLAVAFCCLH 600
    FDLPWYLRML GQCTQTWHRV RKTTQEQLKR NVRFHAFISY SEHDSLWVKN 650
    ELIPNLEKED GSILICLYES YFDPGKSISE NIVSFIEKSY KSIFVLSPNF 700
    VQNEWCHYEF YFAHHNLFHE NSDHIILILL EPIPFYCIPT RYHKLKALLE 750
    KKAYLEWPKD RRKCGLFWAN LRAAINVNVL ATREMYELQT FTELNEESRG 800
    STISLMRTDC L 811
    Length:811
    Mass (Da):94,564
    Last modified:October 17, 2006 - v2
    Checksum:i6BFAAEF76886BFBA
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti96 – 961K → R in BAF84715. (PubMed:14702039)Curated
    Sequence conflicti562 – 5621T → I in AAK26744. (PubMed:11267672)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti163 – 1631A → S.
    Corresponds to variant rs11466649 [ dbSNP | Ensembl ].
    VAR_024669
    Natural varianti167 – 1671L → P.
    Corresponds to variant rs11466650 [ dbSNP | Ensembl ].
    VAR_028125
    Natural varianti241 – 2411N → H.2 Publications
    Corresponds to variant rs11096957 [ dbSNP | Ensembl ].
    VAR_024670
    Natural varianti298 – 2981V → I.
    Corresponds to variant rs11466651 [ dbSNP | Ensembl ].
    VAR_028126
    Natural varianti326 – 3261M → T.
    Corresponds to variant rs11466653 [ dbSNP | Ensembl ].
    VAR_024671
    Natural varianti369 – 3691I → L.2 Publications
    Corresponds to variant rs11096955 [ dbSNP | Ensembl ].
    VAR_024672
    Natural varianti381 – 3811G → D.1 Publication
    Corresponds to variant rs11466655 [ dbSNP | Ensembl ].
    VAR_024673
    Natural varianti469 – 4691R → G.
    Corresponds to variant rs11466656 [ dbSNP | Ensembl ].
    VAR_028127
    Natural varianti473 – 4731I → T.1 Publication
    Corresponds to variant rs11466657 [ dbSNP | Ensembl ].
    VAR_028128
    Natural varianti525 – 5251R → W.
    Corresponds to variant rs11466658 [ dbSNP | Ensembl ].
    VAR_024674
    Natural varianti736 – 7361Y → C.
    Corresponds to variant rs11466660 [ dbSNP | Ensembl ].
    VAR_028129
    Natural varianti775 – 7751I → F.
    Corresponds to variant rs4129009 [ dbSNP | Ensembl ].
    VAR_059832
    Natural varianti775 – 7751I → L.
    Corresponds to variant rs4129009 [ dbSNP | Ensembl ].
    VAR_028130
    Natural varianti775 – 7751I → V.2 Publications
    Corresponds to variant rs4129009 [ dbSNP | Ensembl ].
    VAR_059833
    Natural varianti799 – 7991R → L.
    Corresponds to variant rs4129008 [ dbSNP | Ensembl ].
    VAR_059834
    Natural varianti799 – 7991R → P.
    Corresponds to variant rs4129008 [ dbSNP | Ensembl ].
    VAR_059835
    Natural varianti799 – 7991R → Q.
    Corresponds to variant rs4129008 [ dbSNP | Ensembl ].
    VAR_028131

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF296673 mRNA. Translation: AAK26744.1.
    AB445680 mRNA. Translation: BAG55077.1.
    DQ011504 mRNA. Translation: AAY78479.1.
    DQ011505 mRNA. Translation: AAY78480.1.
    AY358300 mRNA. Translation: AAQ88667.1.
    AK292026 mRNA. Translation: BAF84715.1.
    CH471069 Genomic DNA. Translation: EAW92897.1.
    BC089406 mRNA. Translation: AAH89406.1.
    BC109111 mRNA. Translation: AAI09112.1.
    BC109112 mRNA. Translation: AAI09113.1.
    CCDSiCCDS3445.1.
    RefSeqiNP_001017388.1. NM_001017388.2.
    NP_001182035.1. NM_001195106.1.
    NP_001182036.1. NM_001195107.1.
    NP_001182037.1. NM_001195108.1.
    NP_112218.2. NM_030956.3.
    UniGeneiHs.120551.
    Hs.730896.

    Genome annotation databases

    EnsembliENST00000308973; ENSP00000308925; ENSG00000174123.
    ENST00000361424; ENSP00000354459; ENSG00000174123.
    ENST00000506111; ENSP00000421483; ENSG00000174123.
    ENST00000508334; ENSP00000424923; ENSG00000174123.
    GeneIDi81793.
    KEGGihsa:81793.
    UCSCiuc003gti.3. human.

    Polymorphism databases

    DMDMi116242819.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF296673 mRNA. Translation: AAK26744.1 .
    AB445680 mRNA. Translation: BAG55077.1 .
    DQ011504 mRNA. Translation: AAY78479.1 .
    DQ011505 mRNA. Translation: AAY78480.1 .
    AY358300 mRNA. Translation: AAQ88667.1 .
    AK292026 mRNA. Translation: BAF84715.1 .
    CH471069 Genomic DNA. Translation: EAW92897.1 .
    BC089406 mRNA. Translation: AAH89406.1 .
    BC109111 mRNA. Translation: AAI09112.1 .
    BC109112 mRNA. Translation: AAI09113.1 .
    CCDSi CCDS3445.1.
    RefSeqi NP_001017388.1. NM_001017388.2.
    NP_001182035.1. NM_001195106.1.
    NP_001182036.1. NM_001195107.1.
    NP_001182037.1. NM_001195108.1.
    NP_112218.2. NM_030956.3.
    UniGenei Hs.120551.
    Hs.730896.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2J67 X-ray 2.20 A/B 622-776 [» ]
    ProteinModelPortali Q9BXR5.
    SMRi Q9BXR5. Positions 1-569, 628-776.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000308925.

    PTM databases

    PhosphoSitei Q9BXR5.

    Polymorphism databases

    DMDMi 116242819.

    Proteomic databases

    PaxDbi Q9BXR5.
    PRIDEi Q9BXR5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000308973 ; ENSP00000308925 ; ENSG00000174123 .
    ENST00000361424 ; ENSP00000354459 ; ENSG00000174123 .
    ENST00000506111 ; ENSP00000421483 ; ENSG00000174123 .
    ENST00000508334 ; ENSP00000424923 ; ENSG00000174123 .
    GeneIDi 81793.
    KEGGi hsa:81793.
    UCSCi uc003gti.3. human.

    Organism-specific databases

    CTDi 81793.
    GeneCardsi GC04M038773.
    HGNCi HGNC:15634. TLR10.
    MIMi 606270. gene.
    neXtProti NX_Q9BXR5.
    PharmGKBi PA38011.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG272762.
    HOGENOMi HOG000008676.
    HOVERGENi HBG023180.
    InParanoidi Q9BXR5.
    KOi K10171.
    OMAi TSKILEM.
    OrthoDBi EOG7GN2M5.
    PhylomeDBi Q9BXR5.
    TreeFami TF351113.

    Enzyme and pathway databases

    Reactomei REACT_27215. MyD88 cascade initiated on plasma membrane.
    REACT_9027. Toll Like Receptor 10 (TLR10) Cascade.

    Miscellaneous databases

    EvolutionaryTracei Q9BXR5.
    GeneWikii TLR10.
    GenomeRNAii 81793.
    NextBioi 35489020.
    PROi Q9BXR5.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9BXR5.
    Bgeei Q9BXR5.
    CleanExi HS_TLR10.
    Genevestigatori Q9BXR5.

    Family and domain databases

    Gene3Di 3.40.50.10140. 1 hit.
    InterProi IPR000483. Cys-rich_flank_reg_C.
    IPR001611. Leu-rich_rpt.
    IPR000157. TIR_dom.
    IPR027182. TLR10.
    IPR017241. Toll-like_receptor.
    [Graphical view ]
    PANTHERi PTHR24365:SF131. PTHR24365:SF131. 1 hit.
    Pfami PF00560. LRR_1. 1 hit.
    PF13504. LRR_7. 1 hit.
    PF13855. LRR_8. 1 hit.
    PF01582. TIR. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF037595. Toll-like_receptor. 1 hit.
    SMARTi SM00082. LRRCT. 1 hit.
    SM00255. TIR. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52200. SSF52200. 1 hit.
    PROSITEi PS51450. LRR. 9 hits.
    PS50104. TIR. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of hTLR10: a novel human Toll-like receptor preferentially expressed in immune cells."
      Chuang T.-H., Ulevitch R.J.
      Biochim. Biophys. Acta 1518:157-161(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Spleen.
    2. "Natural selection in the TLR-related genes in the course of primate evolution."
      Nakajima T., Ohtani H., Satta Y., Uno Y., Akari H., Ishida T., Kimura A.
      Immunogenetics 60:727-735(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "The heterogeneous allelic repertoire of human Toll-Like receptor (TLR) genes."
      Georgel P., Macquin C., Bahram S.
      PLoS ONE 4:E7803-E7803(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT ASP-381.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS HIS-241; LEU-369 AND VAL-775.
      Tissue: Spleen.
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS HIS-241; LEU-369; THR-473 AND VAL-775.
      Tissue: Lymph.
    8. "The crystal structure of the human toll-like receptor 10 cytoplasmic domain reveals a putative signaling dimer."
      Nyman T., Stenmark P., Flodin S., Johansson I., Hammarstrom M., Nordlund P.
      J. Biol. Chem. 283:11861-11865(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) OF 622-776, SUBUNIT.

    Entry informationi

    Entry nameiTLR10_HUMAN
    AccessioniPrimary (citable) accession number: Q9BXR5
    Secondary accession number(s): A8K7L1
    , B3Y668, D1CS21, D1CS22, Q32MI7, Q32MI8, Q5FWG4, Q6UXL3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 31, 2002
    Last sequence update: October 17, 2006
    Last modified: October 1, 2014
    This is version 132 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human cell differentiation molecules
      CD nomenclature of surface proteins of human leucocytes and list of entries
    2. Human chromosome 4
      Human chromosome 4: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    7. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3