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Protein

Toll-like receptor 10

Gene

TLR10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Participates in the innate immune response to microbial agents. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity).By similarity

GO - Molecular functioni

  • transmembrane signaling receptor activity Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Immunity, Inflammatory response, Innate immunity

Enzyme and pathway databases

BioCyciZFISH:ENSG00000174123-MONOMER.
ReactomeiR-HSA-168142. Toll Like Receptor 10 (TLR10) Cascade.
R-HSA-5603037. IRAK4 deficiency (TLR5).
R-HSA-975871. MyD88 cascade initiated on plasma membrane.
SIGNORiQ9BXR5.

Names & Taxonomyi

Protein namesi
Recommended name:
Toll-like receptor 10
Alternative name(s):
CD_antigen: CD290
Gene namesi
Name:TLR10
ORF Names:UNQ315/PRO358
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:15634. TLR10.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini20 – 576ExtracellularSequence analysisAdd BLAST557
Transmembranei577 – 597HelicalSequence analysisAdd BLAST21
Topological domaini598 – 811CytoplasmicSequence analysisAdd BLAST214

GO - Cellular componenti

  • integral component of plasma membrane Source: GO_Central
  • membrane Source: UniProtKB
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi81793.
OpenTargetsiENSG00000174123.
PharmGKBiPA38011.

Polymorphism and mutation databases

BioMutaiTLR10.
DMDMi116242819.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000003473920 – 811Toll-like receptor 10Add BLAST792

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi33N-linked (GlcNAc...)Sequence analysis1
Glycosylationi36N-linked (GlcNAc...)Sequence analysis1
Glycosylationi140N-linked (GlcNAc...)Sequence analysis1
Glycosylationi189N-linked (GlcNAc...)Sequence analysis1
Glycosylationi236N-linked (GlcNAc...)Sequence analysis1
Glycosylationi278N-linked (GlcNAc...)Sequence analysis1
Glycosylationi330N-linked (GlcNAc...)Sequence analysis1
Glycosylationi416N-linked (GlcNAc...)Sequence analysis1
Glycosylationi427N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9BXR5.
PeptideAtlasiQ9BXR5.
PRIDEiQ9BXR5.

PTM databases

iPTMnetiQ9BXR5.
PhosphoSitePlusiQ9BXR5.

Expressioni

Tissue specificityi

Highly expressed in spleen, lymph node, thymus, tonsil and at lower levels in lung. Highly expressed in promyelocytic HL-60 cells and in B-cell lines.

Gene expression databases

BgeeiENSG00000174123.
CleanExiHS_TLR10.
ExpressionAtlasiQ9BXR5. baseline and differential.
GenevisibleiQ9BXR5. HS.

Interactioni

Subunit structurei

Binds MYD88 via their respective TIR domains (By similarity). Homodimer (Potential).By similarityCurated

Protein-protein interaction databases

STRINGi9606.ENSP00000308925.

Structurei

Secondary structure

1811
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi634 – 639Combined sources6
Helixi642 – 644Combined sources3
Helixi645 – 650Combined sources6
Helixi652 – 656Combined sources5
Helixi668 – 671Combined sources4
Helixi678 – 687Combined sources10
Beta strandi689 – 696Combined sources8
Helixi698 – 703Combined sources6
Helixi705 – 707Combined sources3
Helixi709 – 712Combined sources4
Turni717 – 719Combined sources3
Beta strandi725 – 731Combined sources7
Helixi735 – 737Combined sources3
Helixi743 – 750Combined sources8
Beta strandi754 – 756Combined sources3
Helixi761 – 763Combined sources3
Helixi764 – 775Combined sources12

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2J67X-ray2.20A/B622-776[»]
ProteinModelPortaliQ9BXR5.
SMRiQ9BXR5.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9BXR5.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati24 – 46LRR 1Add BLAST23
Repeati49 – 70LRR 2Add BLAST22
Repeati73 – 94LRR 3Add BLAST22
Repeati97 – 118LRR 4Add BLAST22
Repeati119 – 139LRR 5Add BLAST21
Repeati143 – 166LRR 6Add BLAST24
Repeati296 – 321LRR 7Add BLAST26
Repeati325 – 348LRR 8Add BLAST24
Repeati349 – 368LRR 9Add BLAST20
Repeati373 – 394LRR 10Add BLAST22
Repeati398 – 419LRR 11Add BLAST22
Repeati422 – 442LRR 12Add BLAST21
Repeati444 – 465LRR 13Add BLAST22
Repeati467 – 488LRR 14Add BLAST22
Repeati489 – 509LRR 15Add BLAST21
Domaini522 – 576LRRCTAdd BLAST55
Domaini632 – 778TIRPROSITE-ProRule annotationAdd BLAST147

Sequence similaritiesi

Belongs to the Toll-like receptor family.Curated
Contains 15 LRR (leucine-rich) repeats.Curated
Contains 1 LRRCT domain.Curated
Contains 1 TIR domain.PROSITE-ProRule annotation

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4641. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00760000119006.
HOGENOMiHOG000008676.
HOVERGENiHBG023180.
InParanoidiQ9BXR5.
KOiK10171.
OMAiVDLLWDD.
OrthoDBiEOG091G0356.
PhylomeDBiQ9BXR5.
TreeFamiTF351113.

Family and domain databases

Gene3Di3.40.50.10140. 1 hit.
3.80.10.10. 2 hits.
InterProiIPR000483. Cys-rich_flank_reg_C.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000157. TIR_dom.
IPR027182. TLR10.
IPR017241. Toll-like_receptor.
[Graphical view]
PANTHERiPTHR24365:SF131. PTHR24365:SF131. 2 hits.
PfamiPF00560. LRR_1. 1 hit.
PF13855. LRR_8. 1 hit.
PF01582. TIR. 1 hit.
[Graphical view]
PIRSFiPIRSF037595. Toll-like_receptor. 1 hit.
SMARTiSM00369. LRR_TYP. 4 hits.
SM00082. LRRCT. 1 hit.
SM00255. TIR. 1 hit.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 2 hits.
SSF52200. SSF52200. 1 hit.
PROSITEiPS51450. LRR. 9 hits.
PS50104. TIR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9BXR5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRLIRNIYIF CSIVMTAEGD APELPEEREL MTNCSNMSLR KVPADLTPAT
60 70 80 90 100
TTLDLSYNLL FQLQSSDFHS VSKLRVLILC HNRIQQLDLK TFEFNKELRY
110 120 130 140 150
LDLSNNRLKS VTWYLLAGLR YLDLSFNDFD TMPICEEAGN MSHLEILGLS
160 170 180 190 200
GAKIQKSDFQ KIAHLHLNTV FLGFRTLPHY EEGSLPILNT TKLHIVLPMD
210 220 230 240 250
TNFWVLLRDG IKTSKILEMT NIDGKSQFVS YEMQRNLSLE NAKTSVLLLN
260 270 280 290 300
KVDLLWDDLF LILQFVWHTS VEHFQIRNVT FGGKAYLDHN SFDYSNTVMR
310 320 330 340 350
TIKLEHVHFR VFYIQQDKIY LLLTKMDIEN LTISNAQMPH MLFPNYPTKF
360 370 380 390 400
QYLNFANNIL TDELFKRTIQ LPHLKTLILN GNKLETLSLV SCFANNTPLE
410 420 430 440 450
HLDLSQNLLQ HKNDENCSWP ETVVNMNLSY NKLSDSVFRC LPKSIQILDL
460 470 480 490 500
NNNQIQTVPK ETIHLMALRE LNIAFNFLTD LPGCSHFSRL SVLNIEMNFI
510 520 530 540 550
LSPSLDFVQS CQEVKTLNAG RNPFRCTCEL KNFIQLETYS EVMMVGWSDS
560 570 580 590 600
YTCEYPLNLR GTRLKDVHLH ELSCNTALLI VTIVVIMLVL GLAVAFCCLH
610 620 630 640 650
FDLPWYLRML GQCTQTWHRV RKTTQEQLKR NVRFHAFISY SEHDSLWVKN
660 670 680 690 700
ELIPNLEKED GSILICLYES YFDPGKSISE NIVSFIEKSY KSIFVLSPNF
710 720 730 740 750
VQNEWCHYEF YFAHHNLFHE NSDHIILILL EPIPFYCIPT RYHKLKALLE
760 770 780 790 800
KKAYLEWPKD RRKCGLFWAN LRAAINVNVL ATREMYELQT FTELNEESRG
810
STISLMRTDC L
Length:811
Mass (Da):94,564
Last modified:October 17, 2006 - v2
Checksum:i6BFAAEF76886BFBA
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti96K → R in BAF84715 (PubMed:14702039).Curated1
Sequence conflicti562T → I in AAK26744 (PubMed:11267672).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_024669163A → S.Corresponds to variant rs11466649dbSNPEnsembl.1
Natural variantiVAR_028125167L → P.Corresponds to variant rs11466650dbSNPEnsembl.1
Natural variantiVAR_024670241N → H.2 PublicationsCorresponds to variant rs11096957dbSNPEnsembl.1
Natural variantiVAR_028126298V → I.Corresponds to variant rs11466651dbSNPEnsembl.1
Natural variantiVAR_024671326M → T.Corresponds to variant rs11466653dbSNPEnsembl.1
Natural variantiVAR_024672369I → L.2 PublicationsCorresponds to variant rs11096955dbSNPEnsembl.1
Natural variantiVAR_024673381G → D.1 PublicationCorresponds to variant rs11466655dbSNPEnsembl.1
Natural variantiVAR_028127469R → G.Corresponds to variant rs11466656dbSNPEnsembl.1
Natural variantiVAR_028128473I → T.1 PublicationCorresponds to variant rs11466657dbSNPEnsembl.1
Natural variantiVAR_024674525R → W.Corresponds to variant rs11466658dbSNPEnsembl.1
Natural variantiVAR_028129736Y → C.Corresponds to variant rs11466660dbSNPEnsembl.1
Natural variantiVAR_059832775I → F.Corresponds to variant rs4129009dbSNPEnsembl.1
Natural variantiVAR_028130775I → L.Corresponds to variant rs4129009dbSNPEnsembl.1
Natural variantiVAR_059833775I → V.2 PublicationsCorresponds to variant rs4129009dbSNPEnsembl.1
Natural variantiVAR_059834799R → L.Corresponds to variant rs4129008dbSNPEnsembl.1
Natural variantiVAR_059835799R → P.Corresponds to variant rs4129008dbSNPEnsembl.1
Natural variantiVAR_028131799R → Q.Corresponds to variant rs4129008dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF296673 mRNA. Translation: AAK26744.1.
AB445680 mRNA. Translation: BAG55077.1.
DQ011504 mRNA. Translation: AAY78479.1.
DQ011505 mRNA. Translation: AAY78480.1.
AY358300 mRNA. Translation: AAQ88667.1.
AK292026 mRNA. Translation: BAF84715.1.
CH471069 Genomic DNA. Translation: EAW92897.1.
BC089406 mRNA. Translation: AAH89406.1.
BC109111 mRNA. Translation: AAI09112.1.
BC109112 mRNA. Translation: AAI09113.1.
CCDSiCCDS3445.1.
RefSeqiNP_001017388.1. NM_001017388.2.
NP_001182035.1. NM_001195106.1.
NP_001182036.1. NM_001195107.1.
NP_001182037.1. NM_001195108.1.
NP_112218.2. NM_030956.3.
XP_011512063.1. XM_011513761.2.
XP_011512064.1. XM_011513762.2.
UniGeneiHs.120551.
Hs.730896.

Genome annotation databases

EnsembliENST00000308973; ENSP00000308925; ENSG00000174123.
ENST00000361424; ENSP00000354459; ENSG00000174123.
ENST00000506111; ENSP00000421483; ENSG00000174123.
ENST00000508334; ENSP00000424923; ENSG00000174123.
ENST00000613579; ENSP00000478206; ENSG00000174123.
ENST00000622002; ENSP00000478985; ENSG00000174123.
GeneIDi81793.
KEGGihsa:81793.
UCSCiuc003gti.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF296673 mRNA. Translation: AAK26744.1.
AB445680 mRNA. Translation: BAG55077.1.
DQ011504 mRNA. Translation: AAY78479.1.
DQ011505 mRNA. Translation: AAY78480.1.
AY358300 mRNA. Translation: AAQ88667.1.
AK292026 mRNA. Translation: BAF84715.1.
CH471069 Genomic DNA. Translation: EAW92897.1.
BC089406 mRNA. Translation: AAH89406.1.
BC109111 mRNA. Translation: AAI09112.1.
BC109112 mRNA. Translation: AAI09113.1.
CCDSiCCDS3445.1.
RefSeqiNP_001017388.1. NM_001017388.2.
NP_001182035.1. NM_001195106.1.
NP_001182036.1. NM_001195107.1.
NP_001182037.1. NM_001195108.1.
NP_112218.2. NM_030956.3.
XP_011512063.1. XM_011513761.2.
XP_011512064.1. XM_011513762.2.
UniGeneiHs.120551.
Hs.730896.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2J67X-ray2.20A/B622-776[»]
ProteinModelPortaliQ9BXR5.
SMRiQ9BXR5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000308925.

PTM databases

iPTMnetiQ9BXR5.
PhosphoSitePlusiQ9BXR5.

Polymorphism and mutation databases

BioMutaiTLR10.
DMDMi116242819.

Proteomic databases

PaxDbiQ9BXR5.
PeptideAtlasiQ9BXR5.
PRIDEiQ9BXR5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000308973; ENSP00000308925; ENSG00000174123.
ENST00000361424; ENSP00000354459; ENSG00000174123.
ENST00000506111; ENSP00000421483; ENSG00000174123.
ENST00000508334; ENSP00000424923; ENSG00000174123.
ENST00000613579; ENSP00000478206; ENSG00000174123.
ENST00000622002; ENSP00000478985; ENSG00000174123.
GeneIDi81793.
KEGGihsa:81793.
UCSCiuc003gti.3. human.

Organism-specific databases

CTDi81793.
DisGeNETi81793.
GeneCardsiTLR10.
HGNCiHGNC:15634. TLR10.
MIMi606270. gene.
neXtProtiNX_Q9BXR5.
OpenTargetsiENSG00000174123.
PharmGKBiPA38011.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4641. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00760000119006.
HOGENOMiHOG000008676.
HOVERGENiHBG023180.
InParanoidiQ9BXR5.
KOiK10171.
OMAiVDLLWDD.
OrthoDBiEOG091G0356.
PhylomeDBiQ9BXR5.
TreeFamiTF351113.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000174123-MONOMER.
ReactomeiR-HSA-168142. Toll Like Receptor 10 (TLR10) Cascade.
R-HSA-5603037. IRAK4 deficiency (TLR5).
R-HSA-975871. MyD88 cascade initiated on plasma membrane.
SIGNORiQ9BXR5.

Miscellaneous databases

EvolutionaryTraceiQ9BXR5.
GeneWikiiTLR10.
GenomeRNAii81793.
PROiQ9BXR5.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000174123.
CleanExiHS_TLR10.
ExpressionAtlasiQ9BXR5. baseline and differential.
GenevisibleiQ9BXR5. HS.

Family and domain databases

Gene3Di3.40.50.10140. 1 hit.
3.80.10.10. 2 hits.
InterProiIPR000483. Cys-rich_flank_reg_C.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000157. TIR_dom.
IPR027182. TLR10.
IPR017241. Toll-like_receptor.
[Graphical view]
PANTHERiPTHR24365:SF131. PTHR24365:SF131. 2 hits.
PfamiPF00560. LRR_1. 1 hit.
PF13855. LRR_8. 1 hit.
PF01582. TIR. 1 hit.
[Graphical view]
PIRSFiPIRSF037595. Toll-like_receptor. 1 hit.
SMARTiSM00369. LRR_TYP. 4 hits.
SM00082. LRRCT. 1 hit.
SM00255. TIR. 1 hit.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 2 hits.
SSF52200. SSF52200. 1 hit.
PROSITEiPS51450. LRR. 9 hits.
PS50104. TIR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTLR10_HUMAN
AccessioniPrimary (citable) accession number: Q9BXR5
Secondary accession number(s): A8K7L1
, B3Y668, D1CS21, D1CS22, Q32MI7, Q32MI8, Q5FWG4, Q6UXL3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 31, 2002
Last sequence update: October 17, 2006
Last modified: November 2, 2016
This is version 149 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.