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Q9BXR5 (TLR10_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 127. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (7) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Toll-like receptor 10
Alternative name(s):
CD_antigen=CD290
Gene names
Name:TLR10
ORF Names:UNQ315/PRO358
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length811 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Participates in the innate immune response to microbial agents. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response By similarity.

Subunit structure

Binds MYD88 via their respective TIR domains By similarity. Homodimer Potential. Ref.8

Subcellular location

Membrane; Single-pass type I membrane protein By similarity.

Tissue specificity

Highly expressed in spleen, lymph node, thymus, tonsil and at lower levels in lung. Highly expressed in promyelocytic HL-60 cells and in B-cell lines.

Sequence similarities

Belongs to the Toll-like receptor family.

Contains 15 LRR (leucine-rich) repeats.

Contains 1 LRRCT domain.

Contains 1 TIR domain.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1919 Potential
Chain20 – 811792Toll-like receptor 10
PRO_0000034739

Regions

Topological domain20 – 576557Extracellular Potential
Transmembrane577 – 59721Helical; Potential
Topological domain598 – 811214Cytoplasmic Potential
Repeat24 – 4623LRR 1
Repeat49 – 7022LRR 2
Repeat73 – 9422LRR 3
Repeat97 – 11822LRR 4
Repeat119 – 13921LRR 5
Repeat143 – 16624LRR 6
Repeat296 – 32126LRR 7
Repeat325 – 34824LRR 8
Repeat349 – 36820LRR 9
Repeat373 – 39422LRR 10
Repeat398 – 41922LRR 11
Repeat422 – 44221LRR 12
Repeat444 – 46522LRR 13
Repeat467 – 48822LRR 14
Repeat489 – 50921LRR 15
Domain522 – 57655LRRCT
Domain632 – 778147TIR

Amino acid modifications

Glycosylation331N-linked (GlcNAc...) Potential
Glycosylation361N-linked (GlcNAc...) Potential
Glycosylation1401N-linked (GlcNAc...) Potential
Glycosylation1891N-linked (GlcNAc...) Potential
Glycosylation2361N-linked (GlcNAc...) Potential
Glycosylation2781N-linked (GlcNAc...) Potential
Glycosylation3301N-linked (GlcNAc...) Potential
Glycosylation4161N-linked (GlcNAc...) Potential
Glycosylation4271N-linked (GlcNAc...) Potential

Natural variations

Natural variant1631A → S.
Corresponds to variant rs11466649 [ dbSNP | Ensembl ].
VAR_024669
Natural variant1671L → P.
Corresponds to variant rs11466650 [ dbSNP | Ensembl ].
VAR_028125
Natural variant2411N → H. Ref.5 Ref.7
Corresponds to variant rs11096957 [ dbSNP | Ensembl ].
VAR_024670
Natural variant2981V → I.
Corresponds to variant rs11466651 [ dbSNP | Ensembl ].
VAR_028126
Natural variant3261M → T.
Corresponds to variant rs11466653 [ dbSNP | Ensembl ].
VAR_024671
Natural variant3691I → L. Ref.5 Ref.7
Corresponds to variant rs11096955 [ dbSNP | Ensembl ].
VAR_024672
Natural variant3811G → D. Ref.3
Corresponds to variant rs11466655 [ dbSNP | Ensembl ].
VAR_024673
Natural variant4691R → G.
Corresponds to variant rs11466656 [ dbSNP | Ensembl ].
VAR_028127
Natural variant4731I → T. Ref.7
Corresponds to variant rs11466657 [ dbSNP | Ensembl ].
VAR_028128
Natural variant5251R → W.
Corresponds to variant rs11466658 [ dbSNP | Ensembl ].
VAR_024674
Natural variant7361Y → C.
Corresponds to variant rs11466660 [ dbSNP | Ensembl ].
VAR_028129
Natural variant7751I → F.
Corresponds to variant rs4129009 [ dbSNP | Ensembl ].
VAR_059832
Natural variant7751I → L.
Corresponds to variant rs4129009 [ dbSNP | Ensembl ].
VAR_028130
Natural variant7751I → V. Ref.5 Ref.7
Corresponds to variant rs4129009 [ dbSNP | Ensembl ].
VAR_059833
Natural variant7991R → L.
Corresponds to variant rs4129008 [ dbSNP | Ensembl ].
VAR_059834
Natural variant7991R → P.
Corresponds to variant rs4129008 [ dbSNP | Ensembl ].
VAR_059835
Natural variant7991R → Q.
Corresponds to variant rs4129008 [ dbSNP | Ensembl ].
VAR_028131

Experimental info

Sequence conflict961K → R in BAF84715. Ref.5
Sequence conflict5621T → I in AAK26744. Ref.1

Secondary structure

............................... 811
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q9BXR5 [UniParc].

Last modified October 17, 2006. Version 2.
Checksum: 6BFAAEF76886BFBA

FASTA81194,564
        10         20         30         40         50         60 
MRLIRNIYIF CSIVMTAEGD APELPEEREL MTNCSNMSLR KVPADLTPAT TTLDLSYNLL 

        70         80         90        100        110        120 
FQLQSSDFHS VSKLRVLILC HNRIQQLDLK TFEFNKELRY LDLSNNRLKS VTWYLLAGLR 

       130        140        150        160        170        180 
YLDLSFNDFD TMPICEEAGN MSHLEILGLS GAKIQKSDFQ KIAHLHLNTV FLGFRTLPHY 

       190        200        210        220        230        240 
EEGSLPILNT TKLHIVLPMD TNFWVLLRDG IKTSKILEMT NIDGKSQFVS YEMQRNLSLE 

       250        260        270        280        290        300 
NAKTSVLLLN KVDLLWDDLF LILQFVWHTS VEHFQIRNVT FGGKAYLDHN SFDYSNTVMR 

       310        320        330        340        350        360 
TIKLEHVHFR VFYIQQDKIY LLLTKMDIEN LTISNAQMPH MLFPNYPTKF QYLNFANNIL 

       370        380        390        400        410        420 
TDELFKRTIQ LPHLKTLILN GNKLETLSLV SCFANNTPLE HLDLSQNLLQ HKNDENCSWP 

       430        440        450        460        470        480 
ETVVNMNLSY NKLSDSVFRC LPKSIQILDL NNNQIQTVPK ETIHLMALRE LNIAFNFLTD 

       490        500        510        520        530        540 
LPGCSHFSRL SVLNIEMNFI LSPSLDFVQS CQEVKTLNAG RNPFRCTCEL KNFIQLETYS 

       550        560        570        580        590        600 
EVMMVGWSDS YTCEYPLNLR GTRLKDVHLH ELSCNTALLI VTIVVIMLVL GLAVAFCCLH 

       610        620        630        640        650        660 
FDLPWYLRML GQCTQTWHRV RKTTQEQLKR NVRFHAFISY SEHDSLWVKN ELIPNLEKED 

       670        680        690        700        710        720 
GSILICLYES YFDPGKSISE NIVSFIEKSY KSIFVLSPNF VQNEWCHYEF YFAHHNLFHE 

       730        740        750        760        770        780 
NSDHIILILL EPIPFYCIPT RYHKLKALLE KKAYLEWPKD RRKCGLFWAN LRAAINVNVL 

       790        800        810 
ATREMYELQT FTELNEESRG STISLMRTDC L 

« Hide

References

« Hide 'large scale' references
[1]"Identification of hTLR10: a novel human Toll-like receptor preferentially expressed in immune cells."
Chuang T.-H., Ulevitch R.J.
Biochim. Biophys. Acta 1518:157-161(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Spleen.
[2]"Natural selection in the TLR-related genes in the course of primate evolution."
Nakajima T., Ohtani H., Satta Y., Uno Y., Akari H., Ishida T., Kimura A.
Immunogenetics 60:727-735(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"The heterogeneous allelic repertoire of human Toll-Like receptor (TLR) genes."
Georgel P., Macquin C., Bahram S.
PLoS ONE 4:E7803-E7803(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT ASP-381.
[4]"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. expand/collapse author list , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.
Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[5]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS HIS-241; LEU-369 AND VAL-775.
Tissue: Spleen.
[6]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS HIS-241; LEU-369; THR-473 AND VAL-775.
Tissue: Lymph.
[8]"The crystal structure of the human toll-like receptor 10 cytoplasmic domain reveals a putative signaling dimer."
Nyman T., Stenmark P., Flodin S., Johansson I., Hammarstrom M., Nordlund P.
J. Biol. Chem. 283:11861-11865(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) OF 622-776, SUBUNIT.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF296673 mRNA. Translation: AAK26744.1.
AB445680 mRNA. Translation: BAG55077.1.
DQ011504 mRNA. Translation: AAY78479.1.
DQ011505 mRNA. Translation: AAY78480.1.
AY358300 mRNA. Translation: AAQ88667.1.
AK292026 mRNA. Translation: BAF84715.1.
CH471069 Genomic DNA. Translation: EAW92897.1.
BC089406 mRNA. Translation: AAH89406.1.
BC109111 mRNA. Translation: AAI09112.1.
BC109112 mRNA. Translation: AAI09113.1.
RefSeqNP_001017388.1. NM_001017388.2.
NP_001182035.1. NM_001195106.1.
NP_001182036.1. NM_001195107.1.
NP_001182037.1. NM_001195108.1.
NP_112218.2. NM_030956.3.
UniGeneHs.120551.
Hs.730896.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2J67X-ray2.20A/B622-776[»]
ProteinModelPortalQ9BXR5.
SMRQ9BXR5. Positions 29-565, 628-776.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000308925.

PTM databases

PhosphoSiteQ9BXR5.

Polymorphism databases

DMDM116242819.

Proteomic databases

PaxDbQ9BXR5.
PRIDEQ9BXR5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000308973; ENSP00000308925; ENSG00000174123.
ENST00000361424; ENSP00000354459; ENSG00000174123.
ENST00000506111; ENSP00000421483; ENSG00000174123.
ENST00000508334; ENSP00000424923; ENSG00000174123.
GeneID81793.
KEGGhsa:81793.
UCSCuc003gti.3. human.

Organism-specific databases

CTD81793.
GeneCardsGC04M038773.
HGNCHGNC:15634. TLR10.
MIM606270. gene.
neXtProtNX_Q9BXR5.
PharmGKBPA38011.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG272762.
HOGENOMHOG000008676.
HOVERGENHBG023180.
InParanoidQ9BXR5.
KOK10171.
OMATSKILEM.
OrthoDBEOG7GN2M5.
PhylomeDBQ9BXR5.
TreeFamTF351113.

Enzyme and pathway databases

ReactomeREACT_6900. Immune System.

Gene expression databases

ArrayExpressQ9BXR5.
BgeeQ9BXR5.
CleanExHS_TLR10.
GenevestigatorQ9BXR5.

Family and domain databases

Gene3D3.40.50.10140. 1 hit.
InterProIPR000483. Cys-rich_flank_reg_C.
IPR001611. Leu-rich_rpt.
IPR000157. TIR_dom.
IPR027182. TLR10.
IPR017241. Toll-like_receptor.
[Graphical view]
PANTHERPTHR24365:SF131. PTHR24365:SF131. 1 hit.
PfamPF00560. LRR_1. 1 hit.
PF01582. TIR. 1 hit.
[Graphical view]
PIRSFPIRSF037595. Toll-like_receptor. 1 hit.
SMARTSM00082. LRRCT. 1 hit.
SM00255. TIR. 1 hit.
[Graphical view]
SUPFAMSSF52200. SSF52200. 1 hit.
PROSITEPS51450. LRR. 9 hits.
PS50104. TIR. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceQ9BXR5.
GeneWikiTLR10.
GenomeRNAi81793.
NextBio35489020.
PROQ9BXR5.
SOURCESearch...

Entry information

Entry nameTLR10_HUMAN
AccessionPrimary (citable) accession number: Q9BXR5
Secondary accession number(s): A8K7L1 expand/collapse secondary AC list , B3Y668, D1CS21, D1CS22, Q32MI7, Q32MI8, Q5FWG4, Q6UXL3
Entry history
Integrated into UniProtKB/Swiss-Prot: January 31, 2002
Last sequence update: October 17, 2006
Last modified: April 16, 2014
This is version 127 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 4

Human chromosome 4: entries, gene names and cross-references to MIM

Human cell differentiation molecules

CD nomenclature of surface proteins of human leucocytes and list of entries