Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Toll-like receptor 10

Gene

TLR10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Participates in the innate immune response to microbial agents. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity).By similarity

GO - Molecular functioni

  • transmembrane signaling receptor activity Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionReceptor
Biological processImmunity, Inflammatory response, Innate immunity

Enzyme and pathway databases

ReactomeiR-HSA-168142 Toll Like Receptor 10 (TLR10) Cascade
R-HSA-5603037 IRAK4 deficiency (TLR5)
R-HSA-975871 MyD88 cascade initiated on plasma membrane

Names & Taxonomyi

Protein namesi
Recommended name:
Toll-like receptor 10
Alternative name(s):
CD_antigen: CD290
Gene namesi
Name:TLR10
ORF Names:UNQ315/PRO358
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000174123.10
HGNCiHGNC:15634 TLR10
MIMi606270 gene
neXtProtiNX_Q9BXR5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini20 – 576ExtracellularSequence analysisAdd BLAST557
Transmembranei577 – 597HelicalSequence analysisAdd BLAST21
Topological domaini598 – 811CytoplasmicSequence analysisAdd BLAST214

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi81793
OpenTargetsiENSG00000174123
PharmGKBiPA38011

Polymorphism and mutation databases

BioMutaiTLR10
DMDMi116242819

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000003473920 – 811Toll-like receptor 10Add BLAST792

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi33N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi36N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi140N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi189N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi236N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi278N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi330N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi416N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi427N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9BXR5
PeptideAtlasiQ9BXR5
PRIDEiQ9BXR5
ProteomicsDBi79485

PTM databases

iPTMnetiQ9BXR5
PhosphoSitePlusiQ9BXR5

Expressioni

Tissue specificityi

Highly expressed in spleen, lymph node, thymus, tonsil and at lower levels in lung. Highly expressed in promyelocytic HL-60 cells and in B-cell lines.

Gene expression databases

BgeeiENSG00000174123
CleanExiHS_TLR10
ExpressionAtlasiQ9BXR5 baseline and differential
GenevisibleiQ9BXR5 HS

Interactioni

Subunit structurei

Binds MYD88 via their respective TIR domains (By similarity). Homodimer (Potential).By similarityCurated

Protein-protein interaction databases

BioGridi123585, 10 interactors
IntActiQ9BXR5, 5 interactors
STRINGi9606.ENSP00000308925

Structurei

Secondary structure

1811
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi634 – 639Combined sources6
Helixi642 – 644Combined sources3
Helixi645 – 650Combined sources6
Helixi652 – 656Combined sources5
Helixi668 – 671Combined sources4
Helixi678 – 687Combined sources10
Beta strandi689 – 696Combined sources8
Helixi698 – 703Combined sources6
Helixi705 – 707Combined sources3
Helixi709 – 712Combined sources4
Turni717 – 719Combined sources3
Beta strandi725 – 731Combined sources7
Helixi735 – 737Combined sources3
Helixi743 – 750Combined sources8
Beta strandi754 – 756Combined sources3
Helixi761 – 763Combined sources3
Helixi764 – 775Combined sources12

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2J67X-ray2.20A/B622-776[»]
ProteinModelPortaliQ9BXR5
SMRiQ9BXR5
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9BXR5

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati24 – 46LRR 1Add BLAST23
Repeati49 – 70LRR 2Add BLAST22
Repeati73 – 94LRR 3Add BLAST22
Repeati97 – 118LRR 4Add BLAST22
Repeati119 – 139LRR 5Add BLAST21
Repeati143 – 166LRR 6Add BLAST24
Repeati296 – 321LRR 7Add BLAST26
Repeati325 – 348LRR 8Add BLAST24
Repeati349 – 368LRR 9Add BLAST20
Repeati373 – 394LRR 10Add BLAST22
Repeati398 – 419LRR 11Add BLAST22
Repeati422 – 442LRR 12Add BLAST21
Repeati444 – 465LRR 13Add BLAST22
Repeati467 – 488LRR 14Add BLAST22
Repeati489 – 509LRR 15Add BLAST21
Domaini522 – 576LRRCTAdd BLAST55
Domaini632 – 778TIRPROSITE-ProRule annotationAdd BLAST147

Sequence similaritiesi

Belongs to the Toll-like receptor family.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4641 Eukaryota
COG4886 LUCA
GeneTreeiENSGT00760000119006
HOGENOMiHOG000008676
HOVERGENiHBG023180
InParanoidiQ9BXR5
KOiK10171
OMAiAYLEWPK
OrthoDBiEOG091G0356
PhylomeDBiQ9BXR5
TreeFamiTF351113

Family and domain databases

Gene3Di3.40.50.10140, 1 hit
3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR000483 Cys-rich_flank_reg_C
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
IPR000157 TIR_dom
IPR027182 TLR10
IPR035897 Toll_tir_struct_dom_sf
PANTHERiPTHR24365:SF23 PTHR24365:SF23, 1 hit
PfamiView protein in Pfam
PF00560 LRR_1, 1 hit
PF13855 LRR_8, 1 hit
PF01582 TIR, 1 hit
SMARTiView protein in SMART
SM00369 LRR_TYP, 4 hits
SM00082 LRRCT, 1 hit
SM00255 TIR, 1 hit
SUPFAMiSSF52200 SSF52200, 1 hit
PROSITEiView protein in PROSITE
PS51450 LRR, 9 hits
PS50104 TIR, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9BXR5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRLIRNIYIF CSIVMTAEGD APELPEEREL MTNCSNMSLR KVPADLTPAT
60 70 80 90 100
TTLDLSYNLL FQLQSSDFHS VSKLRVLILC HNRIQQLDLK TFEFNKELRY
110 120 130 140 150
LDLSNNRLKS VTWYLLAGLR YLDLSFNDFD TMPICEEAGN MSHLEILGLS
160 170 180 190 200
GAKIQKSDFQ KIAHLHLNTV FLGFRTLPHY EEGSLPILNT TKLHIVLPMD
210 220 230 240 250
TNFWVLLRDG IKTSKILEMT NIDGKSQFVS YEMQRNLSLE NAKTSVLLLN
260 270 280 290 300
KVDLLWDDLF LILQFVWHTS VEHFQIRNVT FGGKAYLDHN SFDYSNTVMR
310 320 330 340 350
TIKLEHVHFR VFYIQQDKIY LLLTKMDIEN LTISNAQMPH MLFPNYPTKF
360 370 380 390 400
QYLNFANNIL TDELFKRTIQ LPHLKTLILN GNKLETLSLV SCFANNTPLE
410 420 430 440 450
HLDLSQNLLQ HKNDENCSWP ETVVNMNLSY NKLSDSVFRC LPKSIQILDL
460 470 480 490 500
NNNQIQTVPK ETIHLMALRE LNIAFNFLTD LPGCSHFSRL SVLNIEMNFI
510 520 530 540 550
LSPSLDFVQS CQEVKTLNAG RNPFRCTCEL KNFIQLETYS EVMMVGWSDS
560 570 580 590 600
YTCEYPLNLR GTRLKDVHLH ELSCNTALLI VTIVVIMLVL GLAVAFCCLH
610 620 630 640 650
FDLPWYLRML GQCTQTWHRV RKTTQEQLKR NVRFHAFISY SEHDSLWVKN
660 670 680 690 700
ELIPNLEKED GSILICLYES YFDPGKSISE NIVSFIEKSY KSIFVLSPNF
710 720 730 740 750
VQNEWCHYEF YFAHHNLFHE NSDHIILILL EPIPFYCIPT RYHKLKALLE
760 770 780 790 800
KKAYLEWPKD RRKCGLFWAN LRAAINVNVL ATREMYELQT FTELNEESRG
810
STISLMRTDC L
Length:811
Mass (Da):94,564
Last modified:October 17, 2006 - v2
Checksum:i6BFAAEF76886BFBA
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti96K → R in BAF84715 (PubMed:14702039).Curated1
Sequence conflicti562T → I in AAK26744 (PubMed:11267672).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_024669163A → S. Corresponds to variant dbSNP:rs11466649Ensembl.1
Natural variantiVAR_028125167L → P. Corresponds to variant dbSNP:rs11466650Ensembl.1
Natural variantiVAR_024670241N → H2 PublicationsCorresponds to variant dbSNP:rs11096957Ensembl.1
Natural variantiVAR_028126298V → I. Corresponds to variant dbSNP:rs11466651Ensembl.1
Natural variantiVAR_024671326M → T. Corresponds to variant dbSNP:rs11466653Ensembl.1
Natural variantiVAR_024672369I → L2 PublicationsCorresponds to variant dbSNP:rs11096955Ensembl.1
Natural variantiVAR_024673381G → D1 PublicationCorresponds to variant dbSNP:rs11466655Ensembl.1
Natural variantiVAR_028127469R → G. Corresponds to variant dbSNP:rs11466656Ensembl.1
Natural variantiVAR_028128473I → T1 PublicationCorresponds to variant dbSNP:rs11466657Ensembl.1
Natural variantiVAR_024674525R → W. Corresponds to variant dbSNP:rs11466658Ensembl.1
Natural variantiVAR_028129736Y → C. Corresponds to variant dbSNP:rs11466660Ensembl.1
Natural variantiVAR_059832775I → F. Corresponds to variant dbSNP:rs4129009Ensembl.1
Natural variantiVAR_028130775I → L. Corresponds to variant dbSNP:rs4129009Ensembl.1
Natural variantiVAR_059833775I → V2 PublicationsCorresponds to variant dbSNP:rs4129009Ensembl.1
Natural variantiVAR_059834799R → L. Corresponds to variant dbSNP:rs4129008Ensembl.1
Natural variantiVAR_059835799R → P. Corresponds to variant dbSNP:rs4129008Ensembl.1
Natural variantiVAR_028131799R → Q. Corresponds to variant dbSNP:rs4129008Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF296673 mRNA Translation: AAK26744.1
AB445680 mRNA Translation: BAG55077.1
DQ011504 mRNA Translation: AAY78479.1
DQ011505 mRNA Translation: AAY78480.1
AY358300 mRNA Translation: AAQ88667.1
AK292026 mRNA Translation: BAF84715.1
CH471069 Genomic DNA Translation: EAW92897.1
BC089406 mRNA Translation: AAH89406.1
BC109111 mRNA Translation: AAI09112.1
BC109112 mRNA Translation: AAI09113.1
CCDSiCCDS3445.1
RefSeqiNP_001017388.1, NM_001017388.2
NP_001182035.1, NM_001195106.1
NP_001182036.1, NM_001195107.1
NP_001182037.1, NM_001195108.1
NP_112218.2, NM_030956.3
XP_011512063.1, XM_011513761.2
XP_011512064.1, XM_011513762.2
UniGeneiHs.120551
Hs.730896

Genome annotation databases

EnsembliENST00000308973; ENSP00000308925; ENSG00000174123
ENST00000361424; ENSP00000354459; ENSG00000174123
ENST00000506111; ENSP00000421483; ENSG00000174123
ENST00000508334; ENSP00000424923; ENSG00000174123
ENST00000613579; ENSP00000478206; ENSG00000174123
ENST00000622002; ENSP00000478985; ENSG00000174123
GeneIDi81793
KEGGihsa:81793
UCSCiuc003gti.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiTLR10_HUMAN
AccessioniPrimary (citable) accession number: Q9BXR5
Secondary accession number(s): A8K7L1
, B3Y668, D1CS21, D1CS22, Q32MI7, Q32MI8, Q5FWG4, Q6UXL3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 31, 2002
Last sequence update: October 17, 2006
Last modified: June 20, 2018
This is version 161 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health