Q9BXR5 (TLR10_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Toll-like receptor 10

Alternative name(s):
CD_antigen=CD290

Gene names

Name:	TLR10
ORF Names:	UNQ315/PRO358

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	811 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Participates in the innate immune response to microbial agents. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response By similarity.
Subunit structure	Binds MYD88 via their respective TIR domains By similarity. Homodimer Potential. Ref.8
Subcellular location	Membrane; Single-pass type I membrane protein By similarity.
Tissue specificity	Highly expressed in spleen, lymph node, thymus, tonsil and at lower levels in lung. Highly expressed in promyelocytic HL-60 cells and in B-cell lines.
Sequence similarities	Belongs to the Toll-like receptor family. Contains 15 LRR (leucine-rich) repeats. Contains 1 LRRCT domain. Contains 1 TIR domain.

Ontologies

Keywords
Biological process	Immunity Inflammatory response Innate immunity
Cellular component	Membrane
Coding sequence diversity	Polymorphism
Domain	Leucine-rich repeat Repeat Signal Transmembrane Transmembrane helix
Molecular function	Receptor
PTM	Glycoprotein
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	MyD88-dependent toll-like receptor signaling pathway Traceable author statement. Source: Reactome inflammatory response Inferred from electronic annotation. Source: UniProtKB-KW innate immune response Traceable author statement. Source: Reactome positive regulation of inflammatory response Inferred from electronic annotation. Source: InterPro regulation of cytokine secretion Inferred from electronic annotation. Source: InterPro toll-like receptor 10 signaling pathway Inferred from electronic annotation. Source: InterPro
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Traceable author statement. Source: Reactome
Molecular_function	transmembrane signaling receptor activity Traceable author statement Ref.1. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 19

19

Potential

Chain

20 – 811

792

Toll-like receptor 10

PRO_0000034739

Regions

Topological domain

20 – 576

557

Extracellular Potential

Transmembrane

577 – 597

21

Helical; Potential

Topological domain

598 – 811

214

Cytoplasmic Potential

Repeat

24 – 46

23

LRR 1

Repeat

49 – 70

22

LRR 2

Repeat

73 – 94

22

LRR 3

Repeat

97 – 118

22

LRR 4

Repeat

119 – 139

21

LRR 5

Repeat

143 – 166

24

LRR 6

Repeat

296 – 321

26

LRR 7

Repeat

325 – 348

24

LRR 8

Repeat

349 – 368

20

LRR 9

Repeat

373 – 394

22

LRR 10

Repeat

398 – 419

22

LRR 11

Repeat

422 – 442

21

LRR 12

Repeat

444 – 465

22

LRR 13

Repeat

467 – 488

22

LRR 14

Repeat

489 – 509

21

LRR 15

Domain

522 – 576

55

LRRCT

Domain

632 – 778

147

TIR

Amino acid modifications

Glycosylation

33

1

N-linked (GlcNAc...) Potential

Glycosylation

36

1

N-linked (GlcNAc...) Potential

Glycosylation

140

1

N-linked (GlcNAc...) Potential

Glycosylation

189

1

N-linked (GlcNAc...) Potential

Glycosylation

236

1

N-linked (GlcNAc...) Potential

Glycosylation

278

1

N-linked (GlcNAc...) Potential

Glycosylation

330

1

N-linked (GlcNAc...) Potential

Glycosylation

416

1

N-linked (GlcNAc...) Potential

Glycosylation

427

1

N-linked (GlcNAc...) Potential

Natural variations

Natural variant

163

1

A → S.
Corresponds to variant rs11466649 [ dbSNP | Ensembl ].

VAR_024669

Natural variant

167

1

L → P.
Corresponds to variant rs11466650 [ dbSNP | Ensembl ].

VAR_028125

Natural variant

241

1

N → H. Ref.5 Ref.7
Corresponds to variant rs11096957 [ dbSNP | Ensembl ].

VAR_024670

Natural variant

298

1

V → I.
Corresponds to variant rs11466651 [ dbSNP | Ensembl ].

VAR_028126

Natural variant

326

1

M → T.
Corresponds to variant rs11466653 [ dbSNP | Ensembl ].

VAR_024671

Natural variant

369

1

I → L. Ref.5 Ref.7
Corresponds to variant rs11096955 [ dbSNP | Ensembl ].

VAR_024672

Natural variant

381

1

G → D. Ref.3
Corresponds to variant rs11466655 [ dbSNP | Ensembl ].

VAR_024673

Natural variant

469

1

R → G.
Corresponds to variant rs11466656 [ dbSNP | Ensembl ].

VAR_028127

Natural variant

473

1

I → T. Ref.7
Corresponds to variant rs11466657 [ dbSNP | Ensembl ].

VAR_028128

Natural variant

525

1

R → W.
Corresponds to variant rs11466658 [ dbSNP | Ensembl ].

VAR_024674

Natural variant

736

1

Y → C.
Corresponds to variant rs11466660 [ dbSNP | Ensembl ].

VAR_028129

Natural variant

775

1

I → F.
Corresponds to variant rs4129009 [ dbSNP | Ensembl ].

VAR_059832

Natural variant

775

1

I → L.
Corresponds to variant rs4129009 [ dbSNP | Ensembl ].

VAR_028130

Natural variant

775

1

I → V. Ref.5 Ref.7
Corresponds to variant rs4129009 [ dbSNP | Ensembl ].

VAR_059833

Natural variant

799

1

R → L.
Corresponds to variant rs4129008 [ dbSNP | Ensembl ].

VAR_059834

Natural variant

799

1

R → P.
Corresponds to variant rs4129008 [ dbSNP | Ensembl ].

VAR_059835

Natural variant

799

1

R → Q.
Corresponds to variant rs4129008 [ dbSNP | Ensembl ].

VAR_028131

Experimental info

Sequence conflict

96

1

K → R in BAF84715. Ref.5

Sequence conflict

562

1

T → I in AAK26744. Ref.1

Secondary structure

1

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

811

Helix Strand Turn

Details...

Beta strand

634 – 639

6

Helix

642 – 644

3

Helix

645 – 650

6

Helix

652 – 656

5

Helix

668 – 671

4

Helix

678 – 687

10

Beta strand

689 – 696

8

Helix

698 – 703

6

Helix

705 – 707

3

Helix

709 – 712

4

Beta strand

725 – 731

7

Helix

735 – 737

3

Helix

743 – 750

8

Beta strand

754 – 756

3

Helix

761 – 763

3

Helix

764 – 775

12

Sequences

	Sequence		Length	Mass (Da)
	Q9BXR5 [UniParc]. Last modified October 17, 2006. Version 2. Checksum: 6BFAAEF76886BFBA	FASTA	811	94,564
	10 20 30 40 50 60 MRLIRNIYIF CSIVMTAEGD APELPEEREL MTNCSNMSLR KVPADLTPAT TTLDLSYNLL 70 80 90 100 110 120 FQLQSSDFHS VSKLRVLILC HNRIQQLDLK TFEFNKELRY LDLSNNRLKS VTWYLLAGLR 130 140 150 160 170 180 YLDLSFNDFD TMPICEEAGN MSHLEILGLS GAKIQKSDFQ KIAHLHLNTV FLGFRTLPHY 190 200 210 220 230 240 EEGSLPILNT TKLHIVLPMD TNFWVLLRDG IKTSKILEMT NIDGKSQFVS YEMQRNLSLE 250 260 270 280 290 300 NAKTSVLLLN KVDLLWDDLF LILQFVWHTS VEHFQIRNVT FGGKAYLDHN SFDYSNTVMR 310 320 330 340 350 360 TIKLEHVHFR VFYIQQDKIY LLLTKMDIEN LTISNAQMPH MLFPNYPTKF QYLNFANNIL 370 380 390 400 410 420 TDELFKRTIQ LPHLKTLILN GNKLETLSLV SCFANNTPLE HLDLSQNLLQ HKNDENCSWP 430 440 450 460 470 480 ETVVNMNLSY NKLSDSVFRC LPKSIQILDL NNNQIQTVPK ETIHLMALRE LNIAFNFLTD 490 500 510 520 530 540 LPGCSHFSRL SVLNIEMNFI LSPSLDFVQS CQEVKTLNAG RNPFRCTCEL KNFIQLETYS 550 560 570 580 590 600 EVMMVGWSDS YTCEYPLNLR GTRLKDVHLH ELSCNTALLI VTIVVIMLVL GLAVAFCCLH 610 620 630 640 650 660 FDLPWYLRML GQCTQTWHRV RKTTQEQLKR NVRFHAFISY SEHDSLWVKN ELIPNLEKED 670 680 690 700 710 720 GSILICLYES YFDPGKSISE NIVSFIEKSY KSIFVLSPNF VQNEWCHYEF YFAHHNLFHE 730 740 750 760 770 780 NSDHIILILL EPIPFYCIPT RYHKLKALLE KKAYLEWPKD RRKCGLFWAN LRAAINVNVL 790 800 810 ATREMYELQT FTELNEESRG STISLMRTDC L

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification of hTLR10: a novel human Toll-like receptor preferentially expressed in immune cells." Chuang T.-H., Ulevitch R.J. Biochim. Biophys. Acta 1518:157-161(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Spleen.
[2]	"Natural selection in the TLR-related genes in the course of primate evolution." Nakajima T., Ohtani H., Satta Y., Uno Y., Akari H., Ishida T., Kimura A. Immunogenetics 60:727-735(2008) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]	"The heterogeneous allelic repertoire of human Toll-Like receptor (TLR) genes." Georgel P., Macquin C., Bahram S. PLoS ONE 4:E7803-E7803(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], YARIANT ASP-381.
[4]	"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M. Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[5]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS HIS-241; LEU-369 AND VAL-775. Tissue: Spleen.
[6]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS HIS-241; LEU-369; THR-473 AND VAL-775. Tissue: Lymph.
[8]	"The crystal structure of the human toll-like receptor 10 cytoplasmic domain reveals a putative signaling dimer." Nyman T., Stenmark P., Flodin S., Johansson I., Hammarstrom M., Nordlund P. J. Biol. Chem. 283:11861-11865(2008) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) OF 622-776, SUBUNIT.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AF296673 mRNA. Translation: AAK26744.1.
AB445680 mRNA. Translation: BAG55077.1.
DQ011504 mRNA. Translation: AAY78479.1.
DQ011505 mRNA. Translation: AAY78480.1.
AY358300 mRNA. Translation: AAQ88667.1.
AK292026 mRNA. Translation: BAF84715.1.
CH471069 Genomic DNA. Translation: EAW92897.1.
BC089406 mRNA. Translation: AAH89406.1.
BC109111 mRNA. Translation: AAI09112.1.
BC109112 mRNA. Translation: AAI09113.1.

IPI

IPI00008887.

RefSeq

NP_001017388.1. NM_001017388.2.
NP_001182035.1. NM_001195106.1.
NP_001182036.1. NM_001195107.1.
NP_001182037.1. NM_001195108.1.
NP_112218.2. NM_030956.3.

UniGene

Hs.120551.
Hs.730896.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2J67	X-ray	2.20	A/B	622-776	[»]

ProteinModelPortal

Q9BXR5.

ModBase

Search...

Protein-protein interaction databases

STRING

9606.ENSP00000308925.

PTM databases

PhosphoSite

Q9BXR5.

Polymorphism databases

DMDM

116242819.

Proteomic databases

PaxDb

Q9BXR5.

PRIDE

Q9BXR5.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000308973; ENSP00000308925; ENSG00000174123.
ENST00000361424; ENSP00000354459; ENSG00000174123.
ENST00000506111; ENSP00000421483; ENSG00000174123.
ENST00000508334; ENSP00000424923; ENSG00000174123.

GeneID

81793.

KEGG

hsa:81793.

UCSC

uc003gti.3. human.

Organism-specific databases

CTD

81793.

GeneCards

GC04M038773.

HGNC

HGNC:15634. TLR10.

MIM

606270. gene.

neXtProt

NX_Q9BXR5.

PharmGKB

PA38011.

GenAtlas

Search...

Phylogenomic databases

eggNOG

NOG272762.

HOGENOM

HOG000008676.

HOVERGEN

HBG023180.

InParanoid

Q9BXR5.

KO

K10171.

OMA

TSKILEM.

OrthoDB

EOG4SBDXJ.

PhylomeDB

Q9BXR5.

Enzyme and pathway databases

Reactome

REACT_6900. Immune System.

Gene expression databases

ArrayExpress

Q9BXR5.

Bgee

Q9BXR5.

CleanEx

HS_TLR10.

Genevestigator

Q9BXR5.

GermOnline

ENSG00000174123. Homo sapiens.

Family and domain databases

InterPro

IPR000483. Cys-rich_flank_reg_C.
IPR001611. Leu-rich_rpt.
IPR000157. TIR_dom.
IPR027182. TLR10.
IPR017241. Toll-like_receptor.
[Graphical view]

PANTHER

PTHR24365:SF131. PTHR24365:SF131. 1 hit.

Pfam

PF00560. LRR_1. 1 hit.
PF01582. TIR. 1 hit.
[Graphical view]

PIRSF

PIRSF037595. Toll-like_receptor. 1 hit.

SMART

SM00082. LRRCT. 1 hit.
SM00255. TIR. 1 hit.
[Graphical view]

SUPFAM

SSF52200. TIR. 1 hit.

PROSITE

PS51450. LRR. 9 hits.
PS50104. TIR. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

EvolutionaryTrace

Q9BXR5.

GenomeRNAi

81793.

NextBio

35489020.

SOURCE

Search...

Entry information

Entry name

TLR10_HUMAN

Accession

Primary (citable) accession number: Q9BXR5
Secondary accession number(s): A8K7L1 , B3Y668, D1CS21, D1CS22, Q32MI7, Q32MI8, Q5FWG4, Q6UXL3

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 31, 2002
Last sequence update:	October 17, 2006
Last modified:	May 1, 2013
This is version 119 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.