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Q9BXP8

- PAPP2_HUMAN

UniProt

Q9BXP8 - PAPP2_HUMAN

Protein

Pappalysin-2

Gene

PAPPA2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 119 (01 Oct 2014)
      Sequence version 4 (20 Feb 2007)
      Previous versions | rss
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    Functioni

    Metalloproteinase which specifically cleaves IGFBP-5. Shows limited proteolysis toward IGFBP-3.1 Publication

    Catalytic activityi

    Cleavage of the 143-Ser-|-Lys-144 bond in insulin-like growth factor binding protein (IGFBP)-5.

    Cofactori

    Binds 1 zinc ion per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi733 – 7331Zinc; catalyticPROSITE-ProRule annotation
    Active sitei734 – 7341
    Metal bindingi737 – 7371Zinc; catalyticPROSITE-ProRule annotation
    Metal bindingi743 – 7431Zinc; catalyticPROSITE-ProRule annotation

    GO - Molecular functioni

    1. metallopeptidase activity Source: UniProtKB
    2. zinc ion binding Source: UniProtKB

    GO - Biological processi

    1. cell differentiation Source: InterPro
    2. cellular protein metabolic process Source: Reactome
    3. proteolysis Source: UniProtKB
    4. regulation of cell growth Source: UniProtKB

    Keywords - Molecular functioni

    Hydrolase, Metalloprotease, Protease

    Keywords - Ligandi

    Metal-binding, Zinc

    Enzyme and pathway databases

    ReactomeiREACT_15428. Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs).

    Protein family/group databases

    MEROPSiM43.005.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Pappalysin-2 (EC:3.4.24.-)
    Alternative name(s):
    Pregnancy-associated plasma protein A2
    Short name:
    PAPP-A2
    Pregnancy-associated plasma protein E1
    Short name:
    PAPP-E
    Gene namesi
    Name:PAPPA2
    Synonyms:PLAC3
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:14615. PAPPA2.

    Subcellular locationi

    Secreted By similarity

    GO - Cellular componenti

    1. extracellular region Source: Reactome
    2. extracellular vesicular exosome Source: UniProt
    3. intracellular Source: UniProtKB
    4. membrane Source: InterPro

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi734 – 7341E → Q: Loss of activity. 1 Publication

    Organism-specific databases

    PharmGKBiPA33373.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2222Sequence AnalysisAdd
    BLAST
    Propeptidei23 – 234212PRO_0000029249Add
    BLAST
    Chaini235 – 17911557Pappalysin-2PRO_0000029250Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi311 – 3111N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi312 ↔ 403PROSITE-ProRule annotation
    Disulfide bondi499 ↔ 793PROSITE-ProRule annotation
    Disulfide bondi504 ↔ 828PROSITE-ProRule annotation
    Glycosylationi562 – 5621N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi574 – 5741N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi586 ↔ 600PROSITE-ProRule annotation
    Disulfide bondi596 ↔ 612PROSITE-ProRule annotation
    Disulfide bondi628 ↔ 644PROSITE-ProRule annotation
    Disulfide bondi645 ↔ 656PROSITE-ProRule annotation
    Glycosylationi679 – 6791N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi754 ↔ 771Or C-754 with C-783PROSITE-ProRule annotation
    Disulfide bondi758 ↔ 783Or C-788 with C-771PROSITE-ProRule annotation
    Glycosylationi813 – 8131N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi857 – 8571N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi881 ↔ 1045PROSITE-ProRule annotation
    Disulfide bondi884 ↔ 1048PROSITE-ProRule annotation
    Disulfide bondi924 ↔ 1003PROSITE-ProRule annotation
    Glycosylationi941 – 9411N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi946 ↔ 951PROSITE-ProRule annotation
    Disulfide bondi1115 ↔ 1143PROSITE-ProRule annotation
    Disulfide bondi1128 ↔ 1139PROSITE-ProRule annotation
    Disulfide bondi1151 ↔ 1158PROSITE-ProRule annotation
    Disulfide bondi1167 ↔ 1179PROSITE-ProRule annotation
    Disulfide bondi1205 ↔ 1238PROSITE-ProRule annotation
    Disulfide bondi1219 ↔ 1318PROSITE-ProRule annotation
    Glycosylationi1243 – 12431N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1308 – 13081N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1326 – 13261N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1344 – 13441N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi1371 ↔ 1385PROSITE-ProRule annotation
    Disulfide bondi1396 ↔ 1448PROSITE-ProRule annotation
    Glycosylationi1408 – 14081N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi1423 ↔ 1459PROSITE-ProRule annotation
    Glycosylationi1456 – 14561N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi1464 ↔ 1508PROSITE-ProRule annotation
    Glycosylationi1476 – 14761N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi1479 ↔ 1489PROSITE-ProRule annotation
    Disulfide bondi1493 ↔ 1521PROSITE-ProRule annotation
    Disulfide bondi1525 ↔ 1579PROSITE-ProRule annotation
    Disulfide bondi1541 ↔ 1552PROSITE-ProRule annotation
    Disulfide bondi1556 ↔ 1590PROSITE-ProRule annotation
    Disulfide bondi1595 ↔ 1633PROSITE-ProRule annotation
    Disulfide bondi1608 ↔ 1618PROSITE-ProRule annotation
    Disulfide bondi1622 ↔ 1646PROSITE-ProRule annotation
    Disulfide bondi1653 ↔ 1714PROSITE-ProRule annotation
    Disulfide bondi1667 ↔ 1677PROSITE-ProRule annotation
    Disulfide bondi1681 ↔ 1729PROSITE-ProRule annotation
    Glycosylationi1694 – 16941N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi1733 ↔ 1751PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Zymogen

    Proteomic databases

    MaxQBiQ9BXP8.
    PaxDbiQ9BXP8.
    PRIDEiQ9BXP8.

    PTM databases

    PhosphoSiteiQ9BXP8.

    Expressioni

    Tissue specificityi

    Expressed abundantly in placenta, and non-pregnant mammary gland with low expression in the kidney, fetal brain and pancreas.2 Publications

    Gene expression databases

    BgeeiQ9BXP8.
    CleanExiHS_PAPPA2.
    GenevestigatoriQ9BXP8.

    Organism-specific databases

    HPAiHPA018412.
    HPA018430.

    Interactioni

    Subunit structurei

    Monomer.

    Protein-protein interaction databases

    BioGridi121951. 3 interactions.
    IntActiQ9BXP8. 3 interactions.
    MINTiMINT-1181124.
    STRINGi9606.ENSP00000356634.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9BXP8.
    SMRiQ9BXP8. Positions 1463-1683.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini1393 – 146169Sushi 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini1462 – 152160Sushi 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini1523 – 159270Sushi 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini1593 – 164856Sushi 4PROSITE-ProRule annotationAdd
    BLAST
    Domaini1651 – 173181Sushi 5PROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni442 – 754313MetalloproteaseAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi171 – 1744Poly-Thr
    Compositional biasi1654 – 16574Poly-Pro

    Sequence similaritiesi

    Belongs to the peptidase M43B family.Curated
    Contains 5 Sushi (CCP/SCR) domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Signal, Sushi

    Phylogenomic databases

    eggNOGiNOG128309.
    HOGENOMiHOG000033711.
    HOVERGENiHBG053501.
    InParanoidiQ9BXP8.
    KOiK08647.
    OMAiPFMASCR.
    OrthoDBiEOG7HB58B.
    PhylomeDBiQ9BXP8.
    TreeFamiTF331636.

    Family and domain databases

    Gene3Di2.60.120.200. 1 hit.
    InterProiIPR008985. ConA-like_lec_gl_sf.
    IPR013320. ConA-like_subgrp.
    IPR003961. Fibronectin_type3.
    IPR011936. Myxo_disulph_rpt.
    IPR000800. Notch_dom.
    IPR026918. PAPPA2.
    IPR008754. Peptidase_M43.
    IPR000436. Sushi_SCR_CCP.
    [Graphical view]
    PANTHERiPTHR19325:SF349. PTHR19325:SF349. 1 hit.
    PfamiPF00066. Notch. 2 hits.
    PF05572. Peptidase_M43. 1 hit.
    PF00084. Sushi. 1 hit.
    [Graphical view]
    SMARTiSM00032. CCP. 4 hits.
    SM00060. FN3. 1 hit.
    SM00004. NL. 2 hits.
    [Graphical view]
    SUPFAMiSSF49265. SSF49265. 2 hits.
    SSF49899. SSF49899. 1 hit.
    SSF57535. SSF57535. 3 hits.
    TIGRFAMsiTIGR02232. myxo_disulf_rpt. 1 hit.
    PROSITEiPS50923. SUSHI. 3 hits.
    PS00142. ZINC_PROTEASE. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9BXP8-1) [UniParc]FASTAAdd to Basket

    Also known as: Papp-e(1)

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MMCLKILRIS LAILAGWALC SANSELGWTR KKSLVEREHL NQVLLEGERC     50
    WLGAKVRRPR ASPQHHLFGV YPSRAGNYLR PYPVGEQEIH HTGRSKPDTE 100
    GNAVSLVPPD LTENPAGLRG AVEEPAAPWV GDSPIGQSEL LGDDDAYLGN 150
    QRSKESLGEA GIQKGSAMAA TTTTAIFTTL NEPKPETQRR GWAKSRQRRQ 200
    VWKRRAEDGQ GDSGISSHFQ PWPKHSLKHR VKKSPPEESN QNGGEGSYRE 250
    AETFNSQVGL PILYFSGRRE RLLLRPEVLA EIPREAFTVE AWVKPEGGQN 300
    NPAIIAGVFD NCSHTVSDKG WALGIRSGKD KGKRDARFFF SLCTDRVKKA 350
    TILISHSRYQ PGTWTHVAAT YDGRHMALYV DGTQVASSLD QSGPLNSPFM 400
    ASCRSLLLGG DSSEDGHYFR GHLGTLVFWS TALPQSHFQH SSQHSSGEEE 450
    ATDLVLTASF EPVNTEWVPF RDEKYPRLEV LQGFEPEPEI LSPLQPPLCG 500
    QTVCDNVELI SQYNGYWPLR GEKVIRYQVV NICDDEGLNP IVSEEQIRLQ 550
    HEALNEAFSR YNISWQLSVH QVHNSTLRHR VVLVNCEPSK IGNDHCDPEC 600
    EHPLTGYDGG DCRLQGRCYS WNRRDGLCHV ECNNMLNDFD DGDCCDPQVA 650
    DVRKTCFDPD SPKRAYMSVK ELKEALQLNS THFLNIYFAS SVREDLAGAA 700
    TWPWDKDAVT HLGGIVLSPA YYGMPGHTDT MIHEVGHVLG LYHVFKGVSE 750
    RESCNDPCKE TVPSMETGDL CADTAPTPKS ELCREPEPTS DTCGFTRFPG 800
    APFTNYMSYT DDNCTDNFTP NQVARMHCYL DLVYQQWTES RKPTPIPIPP 850
    MVIGQTNKSL TIHWLPPISG VVYDRASGSL CGACTEDGTF RQYVHTASSR 900
    RVCDSSGYWT PEEAVGPPDV DQPCEPSLQA WSPEVHLYHM NMTVPCPTEG 950
    CSLELLFQHP VQADTLTLWV TSFFMESSQV LFDTEILLEN KESVHLGPLD 1000
    TFCDIPLTIK LHVDGKVSGV KVYTFDERIE IDAALLTSQP HSPLCSGCRP 1050
    VRYQVLRDPP FASGLPVVVT HSHRKFTDVE VTPGQMYQYQ VLAEAGGELG 1100
    EASPPLNHIH GAPYCGDGKV SERLGEECDD GDLVSGDGCS KVCELEEGFN 1150
    CVGEPSLCYM YEGDGICEPF ERKTSIVDCG IYTPKGYLDQ WATRAYSSHE 1200
    DKKKCPVSLV TGEPHSLICT SYHPDLPNHR PLTGWFPCVA SENETQDDRS 1250
    EQPEGSLKKE DEVWLKVCFN RPGEARAIFI FLTTDGLVPG EHQQPTVTLY 1300
    LTDVRGSNHS LGTYGLSCQH NPLIINVTHH QNVLFHHTTS VLLNFSSPRV 1350
    GISAVALRTS SRIGLSAPSN CISEDEGQNH QGQSCIHRPC GKQDSCPSLL 1400
    LDHADVVNCT SIGPGLMKCA ITCQRGFALQ ASSGQYIRPM QKEILLTCSS 1450
    GHWDQNVSCL PVDCGVPDPS LVNYANFSCS EGTKFLKRCS ISCVPPAKLQ 1500
    GLSPWLTCLE DGLWSLPEVY CKLECDAPPI ILNANLLLPH CLQDNHDVGT 1550
    ICKYECKPGY YVAESAEGKV RNKLLKIQCL EGGIWEQGSC IPVVCEPPPP 1600
    VFEGMYECTN GFSLDSQCVL NCNQEREKLP ILCTKEGLWT QEFKLCENLQ 1650
    GECPPPPSEL NSVEYKCEQG YGIGAVCSPL CVIPPSDPVM LPENITADTL 1700
    EHWMEPVKVQ SIVCTGRRQW HPDPVLVHCI QSCEPFQADG WCDTINNRAY 1750
    CHYDGGDCCS STLSSKKVIP FAADCDLDEC TCRDPKAEEN Q 1791
    Length:1,791
    Mass (Da):198,539
    Last modified:February 20, 2007 - v4
    Checksum:iF436030821EC6EDD
    GO
    Isoform 2 (identifier: Q9BXP8-2) [UniParc]FASTAAdd to Basket

    Also known as: Papp-e(2)

    The sequence of this isoform differs from the canonical sequence as follows:
         811-827: DDNCTDNFTPNQVARMH → GITTVLFCFLLRIHGGL
         828-1791: Missing.

    Show »
    Length:827
    Mass (Da):92,136
    Checksum:iFB3B6F1E944F7C24
    GO

    Sequence cautioni

    The sequence AAL17779.1 differs from that shown. Reason: Erroneous initiation.
    The sequence AAL17780.1 differs from that shown. Reason: Erroneous initiation.
    The sequence CAC11134.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti447 – 4471G → E in AAL17779. (PubMed:11597188)Curated
    Sequence conflicti447 – 4471G → E in CAC11134. (PubMed:11018262)Curated
    Sequence conflicti568 – 5681S → N in AAL17780. (PubMed:11597188)Curated
    Sequence conflicti846 – 8461I → T in AAL17779. (PubMed:11597188)Curated
    Sequence conflicti846 – 8461I → T in CAC11134. (PubMed:11018262)Curated
    Sequence conflicti1343 – 13431L → P in AAL17779. (PubMed:11597188)Curated
    Sequence conflicti1343 – 13431L → P in CAC11134. (PubMed:11018262)Curated
    Sequence conflicti1739 – 17391D → N in CAC11134. (PubMed:11018262)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti171 – 1711T → S.
    Corresponds to variant rs36112782 [ dbSNP | Ensembl ].
    VAR_051595
    Natural varianti1657 – 16571P → R.
    Corresponds to variant rs34602579 [ dbSNP | Ensembl ].
    VAR_051596

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei811 – 82717DDNCT…VARMH → GITTVLFCFLLRIHGGL in isoform 2. 2 PublicationsVSP_012194Add
    BLAST
    Alternative sequencei828 – 1791964Missing in isoform 2. 2 PublicationsVSP_012195Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF311940 mRNA. Translation: AAK31073.1.
    AF342989 mRNA. Translation: AAL17779.1. Different initiation.
    AF342990 mRNA. Translation: AAL17780.1. Different initiation.
    AL031290
    , AL031734, AL139282, AL596254 Genomic DNA. Translation: CAI22721.1.
    AL031734
    , AL031290, AL139282, AL596254 Genomic DNA. Translation: CAI22172.1.
    AL031734, AL596254 Genomic DNA. Translation: CAI22173.1.
    AL139282
    , AL031290, AL031734, AL596254 Genomic DNA. Translation: CAI19567.1.
    AL596254
    , AL031290, AL031734, AL139282 Genomic DNA. Translation: CAH71731.1.
    AL596254, AL031734 Genomic DNA. Translation: CAH71732.1.
    CH471067 Genomic DNA. Translation: EAW91003.1.
    BC117193 mRNA. Translation: AAI17194.3.
    BC117195 mRNA. Translation: AAI17196.3.
    AJ278348 mRNA. Translation: CAC11134.1. Different initiation.
    CCDSiCCDS41438.1. [Q9BXP8-1]
    CCDS41439.1. [Q9BXP8-2]
    RefSeqiNP_064714.2. NM_020318.2. [Q9BXP8-1]
    NP_068755.2. NM_021936.2. [Q9BXP8-2]
    XP_005245479.1. XM_005245422.1. [Q9BXP8-1]
    UniGeneiHs.187284.

    Genome annotation databases

    EnsembliENST00000367661; ENSP00000356633; ENSG00000116183. [Q9BXP8-2]
    ENST00000367662; ENSP00000356634; ENSG00000116183. [Q9BXP8-1]
    GeneIDi60676.
    KEGGihsa:60676.
    UCSCiuc001gky.1. human. [Q9BXP8-2]
    uc001gkz.3. human. [Q9BXP8-1]

    Polymorphism databases

    DMDMi126302580.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF311940 mRNA. Translation: AAK31073.1 .
    AF342989 mRNA. Translation: AAL17779.1 . Different initiation.
    AF342990 mRNA. Translation: AAL17780.1 . Different initiation.
    AL031290
    , AL031734 , AL139282 , AL596254 Genomic DNA. Translation: CAI22721.1 .
    AL031734
    , AL031290 , AL139282 , AL596254 Genomic DNA. Translation: CAI22172.1 .
    AL031734 , AL596254 Genomic DNA. Translation: CAI22173.1 .
    AL139282
    , AL031290 , AL031734 , AL596254 Genomic DNA. Translation: CAI19567.1 .
    AL596254
    , AL031290 , AL031734 , AL139282 Genomic DNA. Translation: CAH71731.1 .
    AL596254 , AL031734 Genomic DNA. Translation: CAH71732.1 .
    CH471067 Genomic DNA. Translation: EAW91003.1 .
    BC117193 mRNA. Translation: AAI17194.3 .
    BC117195 mRNA. Translation: AAI17196.3 .
    AJ278348 mRNA. Translation: CAC11134.1 . Different initiation.
    CCDSi CCDS41438.1. [Q9BXP8-1 ]
    CCDS41439.1. [Q9BXP8-2 ]
    RefSeqi NP_064714.2. NM_020318.2. [Q9BXP8-1 ]
    NP_068755.2. NM_021936.2. [Q9BXP8-2 ]
    XP_005245479.1. XM_005245422.1. [Q9BXP8-1 ]
    UniGenei Hs.187284.

    3D structure databases

    ProteinModelPortali Q9BXP8.
    SMRi Q9BXP8. Positions 1463-1683.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 121951. 3 interactions.
    IntActi Q9BXP8. 3 interactions.
    MINTi MINT-1181124.
    STRINGi 9606.ENSP00000356634.

    Protein family/group databases

    MEROPSi M43.005.

    PTM databases

    PhosphoSitei Q9BXP8.

    Polymorphism databases

    DMDMi 126302580.

    Proteomic databases

    MaxQBi Q9BXP8.
    PaxDbi Q9BXP8.
    PRIDEi Q9BXP8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000367661 ; ENSP00000356633 ; ENSG00000116183 . [Q9BXP8-2 ]
    ENST00000367662 ; ENSP00000356634 ; ENSG00000116183 . [Q9BXP8-1 ]
    GeneIDi 60676.
    KEGGi hsa:60676.
    UCSCi uc001gky.1. human. [Q9BXP8-2 ]
    uc001gkz.3. human. [Q9BXP8-1 ]

    Organism-specific databases

    CTDi 60676.
    GeneCardsi GC01P176432.
    HGNCi HGNC:14615. PAPPA2.
    HPAi HPA018412.
    HPA018430.
    neXtProti NX_Q9BXP8.
    PharmGKBi PA33373.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG128309.
    HOGENOMi HOG000033711.
    HOVERGENi HBG053501.
    InParanoidi Q9BXP8.
    KOi K08647.
    OMAi PFMASCR.
    OrthoDBi EOG7HB58B.
    PhylomeDBi Q9BXP8.
    TreeFami TF331636.

    Enzyme and pathway databases

    Reactomei REACT_15428. Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs).

    Miscellaneous databases

    ChiTaRSi PAPPA2. human.
    GeneWikii PAPPA2.
    GenomeRNAii 60676.
    NextBioi 65486.
    PROi Q9BXP8.

    Gene expression databases

    Bgeei Q9BXP8.
    CleanExi HS_PAPPA2.
    Genevestigatori Q9BXP8.

    Family and domain databases

    Gene3Di 2.60.120.200. 1 hit.
    InterProi IPR008985. ConA-like_lec_gl_sf.
    IPR013320. ConA-like_subgrp.
    IPR003961. Fibronectin_type3.
    IPR011936. Myxo_disulph_rpt.
    IPR000800. Notch_dom.
    IPR026918. PAPPA2.
    IPR008754. Peptidase_M43.
    IPR000436. Sushi_SCR_CCP.
    [Graphical view ]
    PANTHERi PTHR19325:SF349. PTHR19325:SF349. 1 hit.
    Pfami PF00066. Notch. 2 hits.
    PF05572. Peptidase_M43. 1 hit.
    PF00084. Sushi. 1 hit.
    [Graphical view ]
    SMARTi SM00032. CCP. 4 hits.
    SM00060. FN3. 1 hit.
    SM00004. NL. 2 hits.
    [Graphical view ]
    SUPFAMi SSF49265. SSF49265. 2 hits.
    SSF49899. SSF49899. 1 hit.
    SSF57535. SSF57535. 3 hits.
    TIGRFAMsi TIGR02232. myxo_disulf_rpt. 1 hit.
    PROSITEi PS50923. SUSHI. 3 hits.
    PS00142. ZINC_PROTEASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Pregnancy-associated plasma protein-A2 (PAPP-A2), a novel insulin-like growth factor-binding protein-5 proteinase."
      Overgaard M.T., Boldt H.B., Laursen L.S., Sottrup-Jensen L., Conover C.A., Oxvig C.
      J. Biol. Chem. 276:21849-21853(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), PROTEIN SEQUENCE OF 234-241, TISSUE SPECIFICITY, MUTAGENESIS OF GLU-734, FUNCTION.
      Tissue: Term placenta.
    2. "The characterization of pregnancy associated plasma protein-E and the identification of an alternative splice variant."
      Page N.M., Butlin D.J., Lomthaisong K., Lowry P.J.
      Placenta 22:681-687(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), TISSUE SPECIFICITY.
    3. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    6. Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 20-1791 (ISOFORM 1).
      Tissue: Placenta.

    Entry informationi

    Entry nameiPAPP2_HUMAN
    AccessioniPrimary (citable) accession number: Q9BXP8
    Secondary accession number(s): A9Z1Y8
    , Q96PH7, Q96PH8, Q9H4C9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 7, 2004
    Last sequence update: February 20, 2007
    Last modified: October 1, 2014
    This is version 119 of the entry and version 4 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. Peptidase families
      Classification of peptidase families and list of entries
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3