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Q9BXP8

- PAPP2_HUMAN

UniProt

Q9BXP8 - PAPP2_HUMAN

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Protein

Pappalysin-2

Gene
PAPPA2, PLAC3
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Metalloproteinase which specifically cleaves IGFBP-5. Shows limited proteolysis toward IGFBP-3.1 Publication

Catalytic activityi

Cleavage of the 143-Ser-|-Lys-144 bond in insulin-like growth factor binding protein (IGFBP)-5.

Cofactori

Binds 1 zinc ion per subunit By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi733 – 7331Zinc; catalytic By similarity
Active sitei734 – 7341
Metal bindingi737 – 7371Zinc; catalytic By similarity
Metal bindingi743 – 7431Zinc; catalytic By similarity

GO - Molecular functioni

  1. metallopeptidase activity Source: UniProtKB
  2. zinc ion binding Source: UniProtKB

GO - Biological processi

  1. cell differentiation Source: InterPro
  2. cellular protein metabolic process Source: Reactome
  3. proteolysis Source: UniProtKB
  4. regulation of cell growth Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Metalloprotease, Protease

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_15428. Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs).

Protein family/group databases

MEROPSiM43.005.

Names & Taxonomyi

Protein namesi
Recommended name:
Pappalysin-2 (EC:3.4.24.-)
Alternative name(s):
Pregnancy-associated plasma protein A2
Short name:
PAPP-A2
Pregnancy-associated plasma protein E1
Short name:
PAPP-E
Gene namesi
Name:PAPPA2
Synonyms:PLAC3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:14615. PAPPA2.

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. extracellular region Source: Reactome
  2. extracellular vesicular exosome Source: UniProt
  3. intracellular Source: UniProtKB
  4. membrane Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi734 – 7341E → Q: Loss of activity. 1 Publication

Organism-specific databases

PharmGKBiPA33373.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222 Reviewed predictionAdd
BLAST
Propeptidei23 – 234212PRO_0000029249Add
BLAST
Chaini235 – 17911557Pappalysin-2PRO_0000029250Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi311 – 3111N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi312 ↔ 403 By similarity
Disulfide bondi499 ↔ 793 By similarity
Disulfide bondi504 ↔ 828 By similarity
Glycosylationi562 – 5621N-linked (GlcNAc...) Reviewed prediction
Glycosylationi574 – 5741N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi586 ↔ 600 By similarity
Disulfide bondi596 ↔ 612 By similarity
Disulfide bondi628 ↔ 644 By similarity
Disulfide bondi645 ↔ 656 By similarity
Glycosylationi679 – 6791N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi754 ↔ 771Or C-754 with C-783 By similarity
Disulfide bondi758 ↔ 783Or C-788 with C-771 By similarity
Glycosylationi813 – 8131N-linked (GlcNAc...) Reviewed prediction
Glycosylationi857 – 8571N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi881 ↔ 1045 By similarity
Disulfide bondi884 ↔ 1048 By similarity
Disulfide bondi924 ↔ 1003 By similarity
Glycosylationi941 – 9411N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi946 ↔ 951 By similarity
Disulfide bondi1115 ↔ 1143 By similarity
Disulfide bondi1128 ↔ 1139 By similarity
Disulfide bondi1151 ↔ 1158 By similarity
Disulfide bondi1167 ↔ 1179 By similarity
Disulfide bondi1205 ↔ 1238 By similarity
Disulfide bondi1219 ↔ 1318 By similarity
Glycosylationi1243 – 12431N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1308 – 13081N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1326 – 13261N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1344 – 13441N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi1371 ↔ 1385 By similarity
Disulfide bondi1396 ↔ 1448 By similarity
Glycosylationi1408 – 14081N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi1423 ↔ 1459 By similarity
Glycosylationi1456 – 14561N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi1464 ↔ 1508 By similarity
Glycosylationi1476 – 14761N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi1479 ↔ 1489 By similarity
Disulfide bondi1493 ↔ 1521 By similarity
Disulfide bondi1525 ↔ 1579 By similarity
Disulfide bondi1541 ↔ 1552 By similarity
Disulfide bondi1556 ↔ 1590 By similarity
Disulfide bondi1595 ↔ 1633 By similarity
Disulfide bondi1608 ↔ 1618 By similarity
Disulfide bondi1622 ↔ 1646 By similarity
Disulfide bondi1653 ↔ 1714 By similarity
Disulfide bondi1667 ↔ 1677 By similarity
Disulfide bondi1681 ↔ 1729 By similarity
Glycosylationi1694 – 16941N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi1733 ↔ 1751 By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Proteomic databases

MaxQBiQ9BXP8.
PaxDbiQ9BXP8.
PRIDEiQ9BXP8.

PTM databases

PhosphoSiteiQ9BXP8.

Expressioni

Tissue specificityi

Expressed abundantly in placenta, and non-pregnant mammary gland with low expression in the kidney, fetal brain and pancreas.2 Publications

Gene expression databases

BgeeiQ9BXP8.
CleanExiHS_PAPPA2.
GenevestigatoriQ9BXP8.

Organism-specific databases

HPAiHPA018412.
HPA018430.

Interactioni

Subunit structurei

Monomer.

Protein-protein interaction databases

BioGridi121951. 3 interactions.
IntActiQ9BXP8. 3 interactions.
MINTiMINT-1181124.
STRINGi9606.ENSP00000356634.

Structurei

3D structure databases

ProteinModelPortaliQ9BXP8.
SMRiQ9BXP8. Positions 1463-1683.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1393 – 146169Sushi 1Add
BLAST
Domaini1462 – 152160Sushi 2Add
BLAST
Domaini1523 – 159270Sushi 3Add
BLAST
Domaini1593 – 164856Sushi 4Add
BLAST
Domaini1651 – 173181Sushi 5Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni442 – 754313MetalloproteaseAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi171 – 1744Poly-Thr
Compositional biasi1654 – 16574Poly-Pro

Sequence similaritiesi

Belongs to the peptidase M43B family.

Keywords - Domaini

Repeat, Signal, Sushi

Phylogenomic databases

eggNOGiNOG128309.
HOGENOMiHOG000033711.
HOVERGENiHBG053501.
InParanoidiQ9BXP8.
KOiK08647.
OMAiPFMASCR.
OrthoDBiEOG7HB58B.
PhylomeDBiQ9BXP8.
TreeFamiTF331636.

Family and domain databases

Gene3Di2.60.120.200. 1 hit.
InterProiIPR008985. ConA-like_lec_gl_sf.
IPR013320. ConA-like_subgrp.
IPR003961. Fibronectin_type3.
IPR011936. Myxo_disulph_rpt.
IPR000800. Notch_dom.
IPR026918. PAPPA2.
IPR008754. Peptidase_M43.
IPR000436. Sushi_SCR_CCP.
[Graphical view]
PANTHERiPTHR19325:SF349. PTHR19325:SF349. 1 hit.
PfamiPF00066. Notch. 2 hits.
PF05572. Peptidase_M43. 1 hit.
PF00084. Sushi. 1 hit.
[Graphical view]
SMARTiSM00032. CCP. 4 hits.
SM00060. FN3. 1 hit.
SM00004. NL. 2 hits.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 2 hits.
SSF49899. SSF49899. 1 hit.
SSF57535. SSF57535. 3 hits.
TIGRFAMsiTIGR02232. myxo_disulf_rpt. 1 hit.
PROSITEiPS50923. SUSHI. 3 hits.
PS00142. ZINC_PROTEASE. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9BXP8-1) [UniParc]FASTAAdd to Basket

Also known as: Papp-e(1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MMCLKILRIS LAILAGWALC SANSELGWTR KKSLVEREHL NQVLLEGERC     50
WLGAKVRRPR ASPQHHLFGV YPSRAGNYLR PYPVGEQEIH HTGRSKPDTE 100
GNAVSLVPPD LTENPAGLRG AVEEPAAPWV GDSPIGQSEL LGDDDAYLGN 150
QRSKESLGEA GIQKGSAMAA TTTTAIFTTL NEPKPETQRR GWAKSRQRRQ 200
VWKRRAEDGQ GDSGISSHFQ PWPKHSLKHR VKKSPPEESN QNGGEGSYRE 250
AETFNSQVGL PILYFSGRRE RLLLRPEVLA EIPREAFTVE AWVKPEGGQN 300
NPAIIAGVFD NCSHTVSDKG WALGIRSGKD KGKRDARFFF SLCTDRVKKA 350
TILISHSRYQ PGTWTHVAAT YDGRHMALYV DGTQVASSLD QSGPLNSPFM 400
ASCRSLLLGG DSSEDGHYFR GHLGTLVFWS TALPQSHFQH SSQHSSGEEE 450
ATDLVLTASF EPVNTEWVPF RDEKYPRLEV LQGFEPEPEI LSPLQPPLCG 500
QTVCDNVELI SQYNGYWPLR GEKVIRYQVV NICDDEGLNP IVSEEQIRLQ 550
HEALNEAFSR YNISWQLSVH QVHNSTLRHR VVLVNCEPSK IGNDHCDPEC 600
EHPLTGYDGG DCRLQGRCYS WNRRDGLCHV ECNNMLNDFD DGDCCDPQVA 650
DVRKTCFDPD SPKRAYMSVK ELKEALQLNS THFLNIYFAS SVREDLAGAA 700
TWPWDKDAVT HLGGIVLSPA YYGMPGHTDT MIHEVGHVLG LYHVFKGVSE 750
RESCNDPCKE TVPSMETGDL CADTAPTPKS ELCREPEPTS DTCGFTRFPG 800
APFTNYMSYT DDNCTDNFTP NQVARMHCYL DLVYQQWTES RKPTPIPIPP 850
MVIGQTNKSL TIHWLPPISG VVYDRASGSL CGACTEDGTF RQYVHTASSR 900
RVCDSSGYWT PEEAVGPPDV DQPCEPSLQA WSPEVHLYHM NMTVPCPTEG 950
CSLELLFQHP VQADTLTLWV TSFFMESSQV LFDTEILLEN KESVHLGPLD 1000
TFCDIPLTIK LHVDGKVSGV KVYTFDERIE IDAALLTSQP HSPLCSGCRP 1050
VRYQVLRDPP FASGLPVVVT HSHRKFTDVE VTPGQMYQYQ VLAEAGGELG 1100
EASPPLNHIH GAPYCGDGKV SERLGEECDD GDLVSGDGCS KVCELEEGFN 1150
CVGEPSLCYM YEGDGICEPF ERKTSIVDCG IYTPKGYLDQ WATRAYSSHE 1200
DKKKCPVSLV TGEPHSLICT SYHPDLPNHR PLTGWFPCVA SENETQDDRS 1250
EQPEGSLKKE DEVWLKVCFN RPGEARAIFI FLTTDGLVPG EHQQPTVTLY 1300
LTDVRGSNHS LGTYGLSCQH NPLIINVTHH QNVLFHHTTS VLLNFSSPRV 1350
GISAVALRTS SRIGLSAPSN CISEDEGQNH QGQSCIHRPC GKQDSCPSLL 1400
LDHADVVNCT SIGPGLMKCA ITCQRGFALQ ASSGQYIRPM QKEILLTCSS 1450
GHWDQNVSCL PVDCGVPDPS LVNYANFSCS EGTKFLKRCS ISCVPPAKLQ 1500
GLSPWLTCLE DGLWSLPEVY CKLECDAPPI ILNANLLLPH CLQDNHDVGT 1550
ICKYECKPGY YVAESAEGKV RNKLLKIQCL EGGIWEQGSC IPVVCEPPPP 1600
VFEGMYECTN GFSLDSQCVL NCNQEREKLP ILCTKEGLWT QEFKLCENLQ 1650
GECPPPPSEL NSVEYKCEQG YGIGAVCSPL CVIPPSDPVM LPENITADTL 1700
EHWMEPVKVQ SIVCTGRRQW HPDPVLVHCI QSCEPFQADG WCDTINNRAY 1750
CHYDGGDCCS STLSSKKVIP FAADCDLDEC TCRDPKAEEN Q 1791
Length:1,791
Mass (Da):198,539
Last modified:February 20, 2007 - v4
Checksum:iF436030821EC6EDD
GO
Isoform 2 (identifier: Q9BXP8-2) [UniParc]FASTAAdd to Basket

Also known as: Papp-e(2)

The sequence of this isoform differs from the canonical sequence as follows:
     811-827: DDNCTDNFTPNQVARMH → GITTVLFCFLLRIHGGL
     828-1791: Missing.

Show »
Length:827
Mass (Da):92,136
Checksum:iFB3B6F1E944F7C24
GO

Sequence cautioni

The sequence AAL17779.1 differs from that shown. Reason: Erroneous initiation.
The sequence AAL17780.1 differs from that shown. Reason: Erroneous initiation.
The sequence CAC11134.1 differs from that shown. Reason: Erroneous initiation.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti171 – 1711T → S.
Corresponds to variant rs36112782 [ dbSNP | Ensembl ].
VAR_051595
Natural varianti1657 – 16571P → R.
Corresponds to variant rs34602579 [ dbSNP | Ensembl ].
VAR_051596

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei811 – 82717DDNCT…VARMH → GITTVLFCFLLRIHGGL in isoform 2. VSP_012194Add
BLAST
Alternative sequencei828 – 1791964Missing in isoform 2. VSP_012195Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti447 – 4471G → E in AAL17779. 1 Publication
Sequence conflicti447 – 4471G → E in CAC11134. 1 Publication
Sequence conflicti568 – 5681S → N in AAL17780. 1 Publication
Sequence conflicti846 – 8461I → T in AAL17779. 1 Publication
Sequence conflicti846 – 8461I → T in CAC11134. 1 Publication
Sequence conflicti1343 – 13431L → P in AAL17779. 1 Publication
Sequence conflicti1343 – 13431L → P in CAC11134. 1 Publication
Sequence conflicti1739 – 17391D → N in CAC11134. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF311940 mRNA. Translation: AAK31073.1.
AF342989 mRNA. Translation: AAL17779.1. Different initiation.
AF342990 mRNA. Translation: AAL17780.1. Different initiation.
AL031290
, AL031734, AL139282, AL596254 Genomic DNA. Translation: CAI22721.1.
AL031734
, AL031290, AL139282, AL596254 Genomic DNA. Translation: CAI22172.1.
AL031734, AL596254 Genomic DNA. Translation: CAI22173.1.
AL139282
, AL031290, AL031734, AL596254 Genomic DNA. Translation: CAI19567.1.
AL596254
, AL031290, AL031734, AL139282 Genomic DNA. Translation: CAH71731.1.
AL596254, AL031734 Genomic DNA. Translation: CAH71732.1.
CH471067 Genomic DNA. Translation: EAW91003.1.
BC117193 mRNA. Translation: AAI17194.3.
BC117195 mRNA. Translation: AAI17196.3.
AJ278348 mRNA. Translation: CAC11134.1. Different initiation.
CCDSiCCDS41438.1. [Q9BXP8-1]
CCDS41439.1. [Q9BXP8-2]
RefSeqiNP_064714.2. NM_020318.2. [Q9BXP8-1]
NP_068755.2. NM_021936.2. [Q9BXP8-2]
XP_005245479.1. XM_005245422.1. [Q9BXP8-1]
UniGeneiHs.187284.

Genome annotation databases

EnsembliENST00000367661; ENSP00000356633; ENSG00000116183. [Q9BXP8-2]
ENST00000367662; ENSP00000356634; ENSG00000116183. [Q9BXP8-1]
GeneIDi60676.
KEGGihsa:60676.
UCSCiuc001gky.1. human. [Q9BXP8-2]
uc001gkz.3. human. [Q9BXP8-1]

Polymorphism databases

DMDMi126302580.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF311940 mRNA. Translation: AAK31073.1 .
AF342989 mRNA. Translation: AAL17779.1 . Different initiation.
AF342990 mRNA. Translation: AAL17780.1 . Different initiation.
AL031290
, AL031734 , AL139282 , AL596254 Genomic DNA. Translation: CAI22721.1 .
AL031734
, AL031290 , AL139282 , AL596254 Genomic DNA. Translation: CAI22172.1 .
AL031734 , AL596254 Genomic DNA. Translation: CAI22173.1 .
AL139282
, AL031290 , AL031734 , AL596254 Genomic DNA. Translation: CAI19567.1 .
AL596254
, AL031290 , AL031734 , AL139282 Genomic DNA. Translation: CAH71731.1 .
AL596254 , AL031734 Genomic DNA. Translation: CAH71732.1 .
CH471067 Genomic DNA. Translation: EAW91003.1 .
BC117193 mRNA. Translation: AAI17194.3 .
BC117195 mRNA. Translation: AAI17196.3 .
AJ278348 mRNA. Translation: CAC11134.1 . Different initiation.
CCDSi CCDS41438.1. [Q9BXP8-1 ]
CCDS41439.1. [Q9BXP8-2 ]
RefSeqi NP_064714.2. NM_020318.2. [Q9BXP8-1 ]
NP_068755.2. NM_021936.2. [Q9BXP8-2 ]
XP_005245479.1. XM_005245422.1. [Q9BXP8-1 ]
UniGenei Hs.187284.

3D structure databases

ProteinModelPortali Q9BXP8.
SMRi Q9BXP8. Positions 1463-1683.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 121951. 3 interactions.
IntActi Q9BXP8. 3 interactions.
MINTi MINT-1181124.
STRINGi 9606.ENSP00000356634.

Protein family/group databases

MEROPSi M43.005.

PTM databases

PhosphoSitei Q9BXP8.

Polymorphism databases

DMDMi 126302580.

Proteomic databases

MaxQBi Q9BXP8.
PaxDbi Q9BXP8.
PRIDEi Q9BXP8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000367661 ; ENSP00000356633 ; ENSG00000116183 . [Q9BXP8-2 ]
ENST00000367662 ; ENSP00000356634 ; ENSG00000116183 . [Q9BXP8-1 ]
GeneIDi 60676.
KEGGi hsa:60676.
UCSCi uc001gky.1. human. [Q9BXP8-2 ]
uc001gkz.3. human. [Q9BXP8-1 ]

Organism-specific databases

CTDi 60676.
GeneCardsi GC01P176432.
HGNCi HGNC:14615. PAPPA2.
HPAi HPA018412.
HPA018430.
neXtProti NX_Q9BXP8.
PharmGKBi PA33373.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG128309.
HOGENOMi HOG000033711.
HOVERGENi HBG053501.
InParanoidi Q9BXP8.
KOi K08647.
OMAi PFMASCR.
OrthoDBi EOG7HB58B.
PhylomeDBi Q9BXP8.
TreeFami TF331636.

Enzyme and pathway databases

Reactomei REACT_15428. Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs).

Miscellaneous databases

ChiTaRSi PAPPA2. human.
GeneWikii PAPPA2.
GenomeRNAii 60676.
NextBioi 65486.
PROi Q9BXP8.

Gene expression databases

Bgeei Q9BXP8.
CleanExi HS_PAPPA2.
Genevestigatori Q9BXP8.

Family and domain databases

Gene3Di 2.60.120.200. 1 hit.
InterProi IPR008985. ConA-like_lec_gl_sf.
IPR013320. ConA-like_subgrp.
IPR003961. Fibronectin_type3.
IPR011936. Myxo_disulph_rpt.
IPR000800. Notch_dom.
IPR026918. PAPPA2.
IPR008754. Peptidase_M43.
IPR000436. Sushi_SCR_CCP.
[Graphical view ]
PANTHERi PTHR19325:SF349. PTHR19325:SF349. 1 hit.
Pfami PF00066. Notch. 2 hits.
PF05572. Peptidase_M43. 1 hit.
PF00084. Sushi. 1 hit.
[Graphical view ]
SMARTi SM00032. CCP. 4 hits.
SM00060. FN3. 1 hit.
SM00004. NL. 2 hits.
[Graphical view ]
SUPFAMi SSF49265. SSF49265. 2 hits.
SSF49899. SSF49899. 1 hit.
SSF57535. SSF57535. 3 hits.
TIGRFAMsi TIGR02232. myxo_disulf_rpt. 1 hit.
PROSITEi PS50923. SUSHI. 3 hits.
PS00142. ZINC_PROTEASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Pregnancy-associated plasma protein-A2 (PAPP-A2), a novel insulin-like growth factor-binding protein-5 proteinase."
    Overgaard M.T., Boldt H.B., Laursen L.S., Sottrup-Jensen L., Conover C.A., Oxvig C.
    J. Biol. Chem. 276:21849-21853(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), PROTEIN SEQUENCE OF 234-241, TISSUE SPECIFICITY, MUTAGENESIS OF GLU-734, FUNCTION.
    Tissue: Term placenta.
  2. "The characterization of pregnancy associated plasma protein-E and the identification of an alternative splice variant."
    Page N.M., Butlin D.J., Lomthaisong K., Lowry P.J.
    Placenta 22:681-687(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), TISSUE SPECIFICITY.
  3. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
  6. Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 20-1791 (ISOFORM 1).
    Tissue: Placenta.

Entry informationi

Entry nameiPAPP2_HUMAN
AccessioniPrimary (citable) accession number: Q9BXP8
Secondary accession number(s): A9Z1Y8
, Q96PH7, Q96PH8, Q9H4C9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 7, 2004
Last sequence update: February 20, 2007
Last modified: September 3, 2014
This is version 118 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Peptidase families
    Classification of peptidase families and list of entries
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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