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Q9BXP8

- PAPP2_HUMAN

UniProt

Q9BXP8 - PAPP2_HUMAN

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Protein

Pappalysin-2

Gene

PAPPA2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Metalloproteinase which specifically cleaves IGFBP-5. Shows limited proteolysis toward IGFBP-3.1 Publication

Catalytic activityi

Cleavage of the 143-Ser-|-Lys-144 bond in insulin-like growth factor binding protein (IGFBP)-5.

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi733 – 7331Zinc; catalyticPROSITE-ProRule annotation
Active sitei734 – 7341
Metal bindingi737 – 7371Zinc; catalyticPROSITE-ProRule annotation
Metal bindingi743 – 7431Zinc; catalyticPROSITE-ProRule annotation

GO - Molecular functioni

  1. metallopeptidase activity Source: UniProtKB
  2. zinc ion binding Source: UniProtKB

GO - Biological processi

  1. bone morphogenesis Source: Ensembl
  2. cell differentiation Source: InterPro
  3. cellular protein metabolic process Source: Reactome
  4. proteolysis Source: UniProtKB
  5. regulation of cell growth Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Metalloprotease, Protease

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_15428. Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs).

Protein family/group databases

MEROPSiM43.005.

Names & Taxonomyi

Protein namesi
Recommended name:
Pappalysin-2 (EC:3.4.24.-)
Alternative name(s):
Pregnancy-associated plasma protein A2
Short name:
PAPP-A2
Pregnancy-associated plasma protein E1
Short name:
PAPP-E
Gene namesi
Name:PAPPA2
Synonyms:PLAC3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:14615. PAPPA2.

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. extracellular region Source: Reactome
  2. extracellular vesicular exosome Source: UniProtKB
  3. intracellular Source: UniProtKB
  4. membrane Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi734 – 7341E → Q: Loss of activity. 1 Publication

Organism-specific databases

PharmGKBiPA33373.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222Sequence AnalysisAdd
BLAST
Propeptidei23 – 234212PRO_0000029249Add
BLAST
Chaini235 – 17911557Pappalysin-2PRO_0000029250Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi311 – 3111N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi312 ↔ 403PROSITE-ProRule annotation
Disulfide bondi499 ↔ 793PROSITE-ProRule annotation
Disulfide bondi504 ↔ 828PROSITE-ProRule annotation
Glycosylationi562 – 5621N-linked (GlcNAc...)Sequence Analysis
Glycosylationi574 – 5741N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi586 ↔ 600PROSITE-ProRule annotation
Disulfide bondi596 ↔ 612PROSITE-ProRule annotation
Disulfide bondi628 ↔ 644PROSITE-ProRule annotation
Disulfide bondi645 ↔ 656PROSITE-ProRule annotation
Glycosylationi679 – 6791N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi754 ↔ 771Or C-754 with C-783PROSITE-ProRule annotation
Disulfide bondi758 ↔ 783Or C-788 with C-771PROSITE-ProRule annotation
Glycosylationi813 – 8131N-linked (GlcNAc...)Sequence Analysis
Glycosylationi857 – 8571N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi881 ↔ 1045PROSITE-ProRule annotation
Disulfide bondi884 ↔ 1048PROSITE-ProRule annotation
Disulfide bondi924 ↔ 1003PROSITE-ProRule annotation
Glycosylationi941 – 9411N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi946 ↔ 951PROSITE-ProRule annotation
Disulfide bondi1115 ↔ 1143PROSITE-ProRule annotation
Disulfide bondi1128 ↔ 1139PROSITE-ProRule annotation
Disulfide bondi1151 ↔ 1158PROSITE-ProRule annotation
Disulfide bondi1167 ↔ 1179PROSITE-ProRule annotation
Disulfide bondi1205 ↔ 1238PROSITE-ProRule annotation
Disulfide bondi1219 ↔ 1318PROSITE-ProRule annotation
Glycosylationi1243 – 12431N-linked (GlcNAc...)Sequence Analysis
Glycosylationi1308 – 13081N-linked (GlcNAc...)Sequence Analysis
Glycosylationi1326 – 13261N-linked (GlcNAc...)Sequence Analysis
Glycosylationi1344 – 13441N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi1371 ↔ 1385PROSITE-ProRule annotation
Disulfide bondi1396 ↔ 1448PROSITE-ProRule annotation
Glycosylationi1408 – 14081N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi1423 ↔ 1459PROSITE-ProRule annotation
Glycosylationi1456 – 14561N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi1464 ↔ 1508PROSITE-ProRule annotation
Glycosylationi1476 – 14761N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi1479 ↔ 1489PROSITE-ProRule annotation
Disulfide bondi1493 ↔ 1521PROSITE-ProRule annotation
Disulfide bondi1525 ↔ 1579PROSITE-ProRule annotation
Disulfide bondi1541 ↔ 1552PROSITE-ProRule annotation
Disulfide bondi1556 ↔ 1590PROSITE-ProRule annotation
Disulfide bondi1595 ↔ 1633PROSITE-ProRule annotation
Disulfide bondi1608 ↔ 1618PROSITE-ProRule annotation
Disulfide bondi1622 ↔ 1646PROSITE-ProRule annotation
Disulfide bondi1653 ↔ 1714PROSITE-ProRule annotation
Disulfide bondi1667 ↔ 1677PROSITE-ProRule annotation
Disulfide bondi1681 ↔ 1729PROSITE-ProRule annotation
Glycosylationi1694 – 16941N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi1733 ↔ 1751PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Proteomic databases

MaxQBiQ9BXP8.
PaxDbiQ9BXP8.
PRIDEiQ9BXP8.

PTM databases

PhosphoSiteiQ9BXP8.

Expressioni

Tissue specificityi

Expressed abundantly in placenta, and non-pregnant mammary gland with low expression in the kidney, fetal brain and pancreas.2 Publications

Gene expression databases

BgeeiQ9BXP8.
CleanExiHS_PAPPA2.
GenevestigatoriQ9BXP8.

Organism-specific databases

HPAiHPA018412.
HPA018430.

Interactioni

Subunit structurei

Monomer.

Protein-protein interaction databases

BioGridi121951. 3 interactions.
IntActiQ9BXP8. 3 interactions.
MINTiMINT-1181124.
STRINGi9606.ENSP00000356634.

Structurei

3D structure databases

ProteinModelPortaliQ9BXP8.
SMRiQ9BXP8. Positions 1395-1683.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1393 – 146169Sushi 1PROSITE-ProRule annotationAdd
BLAST
Domaini1462 – 152160Sushi 2PROSITE-ProRule annotationAdd
BLAST
Domaini1523 – 159270Sushi 3PROSITE-ProRule annotationAdd
BLAST
Domaini1593 – 164856Sushi 4PROSITE-ProRule annotationAdd
BLAST
Domaini1651 – 173181Sushi 5PROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni442 – 754313MetalloproteaseAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi171 – 1744Poly-Thr
Compositional biasi1654 – 16574Poly-Pro

Sequence similaritiesi

Belongs to the peptidase M43B family.Curated
Contains 5 Sushi (CCP/SCR) domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Sushi

Phylogenomic databases

eggNOGiNOG128309.
GeneTreeiENSGT00390000009007.
HOGENOMiHOG000033711.
HOVERGENiHBG053501.
InParanoidiQ9BXP8.
KOiK08647.
OMAiPFMASCR.
OrthoDBiEOG7HB58B.
PhylomeDBiQ9BXP8.
TreeFamiTF331636.

Family and domain databases

Gene3Di2.60.120.200. 1 hit.
InterProiIPR013320. ConA-like_dom.
IPR003961. Fibronectin_type3.
IPR011936. Myxo_disulph_rpt.
IPR000800. Notch_dom.
IPR026918. PAPPA2.
IPR008754. Peptidase_M43.
IPR000436. Sushi_SCR_CCP.
[Graphical view]
PANTHERiPTHR19325:SF349. PTHR19325:SF349. 1 hit.
PfamiPF00066. Notch. 2 hits.
PF05572. Peptidase_M43. 1 hit.
PF00084. Sushi. 1 hit.
[Graphical view]
SMARTiSM00032. CCP. 4 hits.
SM00060. FN3. 1 hit.
SM00004. NL. 2 hits.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 2 hits.
SSF49899. SSF49899. 1 hit.
SSF57535. SSF57535. 3 hits.
TIGRFAMsiTIGR02232. myxo_disulf_rpt. 1 hit.
PROSITEiPS50923. SUSHI. 3 hits.
PS00142. ZINC_PROTEASE. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9BXP8-1) [UniParc]FASTAAdd to Basket

Also known as: Papp-e(1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MMCLKILRIS LAILAGWALC SANSELGWTR KKSLVEREHL NQVLLEGERC
60 70 80 90 100
WLGAKVRRPR ASPQHHLFGV YPSRAGNYLR PYPVGEQEIH HTGRSKPDTE
110 120 130 140 150
GNAVSLVPPD LTENPAGLRG AVEEPAAPWV GDSPIGQSEL LGDDDAYLGN
160 170 180 190 200
QRSKESLGEA GIQKGSAMAA TTTTAIFTTL NEPKPETQRR GWAKSRQRRQ
210 220 230 240 250
VWKRRAEDGQ GDSGISSHFQ PWPKHSLKHR VKKSPPEESN QNGGEGSYRE
260 270 280 290 300
AETFNSQVGL PILYFSGRRE RLLLRPEVLA EIPREAFTVE AWVKPEGGQN
310 320 330 340 350
NPAIIAGVFD NCSHTVSDKG WALGIRSGKD KGKRDARFFF SLCTDRVKKA
360 370 380 390 400
TILISHSRYQ PGTWTHVAAT YDGRHMALYV DGTQVASSLD QSGPLNSPFM
410 420 430 440 450
ASCRSLLLGG DSSEDGHYFR GHLGTLVFWS TALPQSHFQH SSQHSSGEEE
460 470 480 490 500
ATDLVLTASF EPVNTEWVPF RDEKYPRLEV LQGFEPEPEI LSPLQPPLCG
510 520 530 540 550
QTVCDNVELI SQYNGYWPLR GEKVIRYQVV NICDDEGLNP IVSEEQIRLQ
560 570 580 590 600
HEALNEAFSR YNISWQLSVH QVHNSTLRHR VVLVNCEPSK IGNDHCDPEC
610 620 630 640 650
EHPLTGYDGG DCRLQGRCYS WNRRDGLCHV ECNNMLNDFD DGDCCDPQVA
660 670 680 690 700
DVRKTCFDPD SPKRAYMSVK ELKEALQLNS THFLNIYFAS SVREDLAGAA
710 720 730 740 750
TWPWDKDAVT HLGGIVLSPA YYGMPGHTDT MIHEVGHVLG LYHVFKGVSE
760 770 780 790 800
RESCNDPCKE TVPSMETGDL CADTAPTPKS ELCREPEPTS DTCGFTRFPG
810 820 830 840 850
APFTNYMSYT DDNCTDNFTP NQVARMHCYL DLVYQQWTES RKPTPIPIPP
860 870 880 890 900
MVIGQTNKSL TIHWLPPISG VVYDRASGSL CGACTEDGTF RQYVHTASSR
910 920 930 940 950
RVCDSSGYWT PEEAVGPPDV DQPCEPSLQA WSPEVHLYHM NMTVPCPTEG
960 970 980 990 1000
CSLELLFQHP VQADTLTLWV TSFFMESSQV LFDTEILLEN KESVHLGPLD
1010 1020 1030 1040 1050
TFCDIPLTIK LHVDGKVSGV KVYTFDERIE IDAALLTSQP HSPLCSGCRP
1060 1070 1080 1090 1100
VRYQVLRDPP FASGLPVVVT HSHRKFTDVE VTPGQMYQYQ VLAEAGGELG
1110 1120 1130 1140 1150
EASPPLNHIH GAPYCGDGKV SERLGEECDD GDLVSGDGCS KVCELEEGFN
1160 1170 1180 1190 1200
CVGEPSLCYM YEGDGICEPF ERKTSIVDCG IYTPKGYLDQ WATRAYSSHE
1210 1220 1230 1240 1250
DKKKCPVSLV TGEPHSLICT SYHPDLPNHR PLTGWFPCVA SENETQDDRS
1260 1270 1280 1290 1300
EQPEGSLKKE DEVWLKVCFN RPGEARAIFI FLTTDGLVPG EHQQPTVTLY
1310 1320 1330 1340 1350
LTDVRGSNHS LGTYGLSCQH NPLIINVTHH QNVLFHHTTS VLLNFSSPRV
1360 1370 1380 1390 1400
GISAVALRTS SRIGLSAPSN CISEDEGQNH QGQSCIHRPC GKQDSCPSLL
1410 1420 1430 1440 1450
LDHADVVNCT SIGPGLMKCA ITCQRGFALQ ASSGQYIRPM QKEILLTCSS
1460 1470 1480 1490 1500
GHWDQNVSCL PVDCGVPDPS LVNYANFSCS EGTKFLKRCS ISCVPPAKLQ
1510 1520 1530 1540 1550
GLSPWLTCLE DGLWSLPEVY CKLECDAPPI ILNANLLLPH CLQDNHDVGT
1560 1570 1580 1590 1600
ICKYECKPGY YVAESAEGKV RNKLLKIQCL EGGIWEQGSC IPVVCEPPPP
1610 1620 1630 1640 1650
VFEGMYECTN GFSLDSQCVL NCNQEREKLP ILCTKEGLWT QEFKLCENLQ
1660 1670 1680 1690 1700
GECPPPPSEL NSVEYKCEQG YGIGAVCSPL CVIPPSDPVM LPENITADTL
1710 1720 1730 1740 1750
EHWMEPVKVQ SIVCTGRRQW HPDPVLVHCI QSCEPFQADG WCDTINNRAY
1760 1770 1780 1790
CHYDGGDCCS STLSSKKVIP FAADCDLDEC TCRDPKAEEN Q
Length:1,791
Mass (Da):198,539
Last modified:February 20, 2007 - v4
Checksum:iF436030821EC6EDD
GO
Isoform 2 (identifier: Q9BXP8-2) [UniParc]FASTAAdd to Basket

Also known as: Papp-e(2)

The sequence of this isoform differs from the canonical sequence as follows:
     811-827: DDNCTDNFTPNQVARMH → GITTVLFCFLLRIHGGL
     828-1791: Missing.

Show »
Length:827
Mass (Da):92,136
Checksum:iFB3B6F1E944F7C24
GO

Sequence cautioni

The sequence AAL17779.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence AAL17780.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence CAC11134.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti447 – 4471G → E in AAL17779. (PubMed:11597188)Curated
Sequence conflicti447 – 4471G → E in CAC11134. (PubMed:11018262)Curated
Sequence conflicti568 – 5681S → N in AAL17780. (PubMed:11597188)Curated
Sequence conflicti846 – 8461I → T in AAL17779. (PubMed:11597188)Curated
Sequence conflicti846 – 8461I → T in CAC11134. (PubMed:11018262)Curated
Sequence conflicti1343 – 13431L → P in AAL17779. (PubMed:11597188)Curated
Sequence conflicti1343 – 13431L → P in CAC11134. (PubMed:11018262)Curated
Sequence conflicti1739 – 17391D → N in CAC11134. (PubMed:11018262)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti171 – 1711T → S.
Corresponds to variant rs36112782 [ dbSNP | Ensembl ].
VAR_051595
Natural varianti1657 – 16571P → R.
Corresponds to variant rs34602579 [ dbSNP | Ensembl ].
VAR_051596

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei811 – 82717DDNCT…VARMH → GITTVLFCFLLRIHGGL in isoform 2. 2 PublicationsVSP_012194Add
BLAST
Alternative sequencei828 – 1791964Missing in isoform 2. 2 PublicationsVSP_012195Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF311940 mRNA. Translation: AAK31073.1.
AF342989 mRNA. Translation: AAL17779.1. Different initiation.
AF342990 mRNA. Translation: AAL17780.1. Different initiation.
AL031290
, AL031734, AL139282, AL596254 Genomic DNA. Translation: CAI22721.1.
AL031734
, AL031290, AL139282, AL596254 Genomic DNA. Translation: CAI22172.1.
AL031734, AL596254 Genomic DNA. Translation: CAI22173.1.
AL139282
, AL031290, AL031734, AL596254 Genomic DNA. Translation: CAI19567.1.
AL596254
, AL031290, AL031734, AL139282 Genomic DNA. Translation: CAH71731.1.
AL596254, AL031734 Genomic DNA. Translation: CAH71732.1.
CH471067 Genomic DNA. Translation: EAW91003.1.
BC117193 mRNA. Translation: AAI17194.3.
BC117195 mRNA. Translation: AAI17196.3.
AJ278348 mRNA. Translation: CAC11134.1. Different initiation.
CCDSiCCDS41438.1. [Q9BXP8-1]
CCDS41439.1. [Q9BXP8-2]
RefSeqiNP_064714.2. NM_020318.2. [Q9BXP8-1]
NP_068755.2. NM_021936.2. [Q9BXP8-2]
XP_005245479.1. XM_005245422.1. [Q9BXP8-1]
UniGeneiHs.187284.

Genome annotation databases

EnsembliENST00000367661; ENSP00000356633; ENSG00000116183. [Q9BXP8-2]
ENST00000367662; ENSP00000356634; ENSG00000116183. [Q9BXP8-1]
GeneIDi60676.
KEGGihsa:60676.
UCSCiuc001gky.1. human. [Q9BXP8-2]
uc001gkz.3. human. [Q9BXP8-1]

Polymorphism databases

DMDMi126302580.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF311940 mRNA. Translation: AAK31073.1 .
AF342989 mRNA. Translation: AAL17779.1 . Different initiation.
AF342990 mRNA. Translation: AAL17780.1 . Different initiation.
AL031290
, AL031734 , AL139282 , AL596254 Genomic DNA. Translation: CAI22721.1 .
AL031734
, AL031290 , AL139282 , AL596254 Genomic DNA. Translation: CAI22172.1 .
AL031734 , AL596254 Genomic DNA. Translation: CAI22173.1 .
AL139282
, AL031290 , AL031734 , AL596254 Genomic DNA. Translation: CAI19567.1 .
AL596254
, AL031290 , AL031734 , AL139282 Genomic DNA. Translation: CAH71731.1 .
AL596254 , AL031734 Genomic DNA. Translation: CAH71732.1 .
CH471067 Genomic DNA. Translation: EAW91003.1 .
BC117193 mRNA. Translation: AAI17194.3 .
BC117195 mRNA. Translation: AAI17196.3 .
AJ278348 mRNA. Translation: CAC11134.1 . Different initiation.
CCDSi CCDS41438.1. [Q9BXP8-1 ]
CCDS41439.1. [Q9BXP8-2 ]
RefSeqi NP_064714.2. NM_020318.2. [Q9BXP8-1 ]
NP_068755.2. NM_021936.2. [Q9BXP8-2 ]
XP_005245479.1. XM_005245422.1. [Q9BXP8-1 ]
UniGenei Hs.187284.

3D structure databases

ProteinModelPortali Q9BXP8.
SMRi Q9BXP8. Positions 1395-1683.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 121951. 3 interactions.
IntActi Q9BXP8. 3 interactions.
MINTi MINT-1181124.
STRINGi 9606.ENSP00000356634.

Protein family/group databases

MEROPSi M43.005.

PTM databases

PhosphoSitei Q9BXP8.

Polymorphism databases

DMDMi 126302580.

Proteomic databases

MaxQBi Q9BXP8.
PaxDbi Q9BXP8.
PRIDEi Q9BXP8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000367661 ; ENSP00000356633 ; ENSG00000116183 . [Q9BXP8-2 ]
ENST00000367662 ; ENSP00000356634 ; ENSG00000116183 . [Q9BXP8-1 ]
GeneIDi 60676.
KEGGi hsa:60676.
UCSCi uc001gky.1. human. [Q9BXP8-2 ]
uc001gkz.3. human. [Q9BXP8-1 ]

Organism-specific databases

CTDi 60676.
GeneCardsi GC01P176432.
HGNCi HGNC:14615. PAPPA2.
HPAi HPA018412.
HPA018430.
neXtProti NX_Q9BXP8.
PharmGKBi PA33373.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG128309.
GeneTreei ENSGT00390000009007.
HOGENOMi HOG000033711.
HOVERGENi HBG053501.
InParanoidi Q9BXP8.
KOi K08647.
OMAi PFMASCR.
OrthoDBi EOG7HB58B.
PhylomeDBi Q9BXP8.
TreeFami TF331636.

Enzyme and pathway databases

Reactomei REACT_15428. Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs).

Miscellaneous databases

ChiTaRSi PAPPA2. human.
GeneWikii PAPPA2.
GenomeRNAii 60676.
NextBioi 65486.
PROi Q9BXP8.

Gene expression databases

Bgeei Q9BXP8.
CleanExi HS_PAPPA2.
Genevestigatori Q9BXP8.

Family and domain databases

Gene3Di 2.60.120.200. 1 hit.
InterProi IPR013320. ConA-like_dom.
IPR003961. Fibronectin_type3.
IPR011936. Myxo_disulph_rpt.
IPR000800. Notch_dom.
IPR026918. PAPPA2.
IPR008754. Peptidase_M43.
IPR000436. Sushi_SCR_CCP.
[Graphical view ]
PANTHERi PTHR19325:SF349. PTHR19325:SF349. 1 hit.
Pfami PF00066. Notch. 2 hits.
PF05572. Peptidase_M43. 1 hit.
PF00084. Sushi. 1 hit.
[Graphical view ]
SMARTi SM00032. CCP. 4 hits.
SM00060. FN3. 1 hit.
SM00004. NL. 2 hits.
[Graphical view ]
SUPFAMi SSF49265. SSF49265. 2 hits.
SSF49899. SSF49899. 1 hit.
SSF57535. SSF57535. 3 hits.
TIGRFAMsi TIGR02232. myxo_disulf_rpt. 1 hit.
PROSITEi PS50923. SUSHI. 3 hits.
PS00142. ZINC_PROTEASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Pregnancy-associated plasma protein-A2 (PAPP-A2), a novel insulin-like growth factor-binding protein-5 proteinase."
    Overgaard M.T., Boldt H.B., Laursen L.S., Sottrup-Jensen L., Conover C.A., Oxvig C.
    J. Biol. Chem. 276:21849-21853(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), PROTEIN SEQUENCE OF 234-241, TISSUE SPECIFICITY, MUTAGENESIS OF GLU-734, FUNCTION.
    Tissue: Term placenta.
  2. "The characterization of pregnancy associated plasma protein-E and the identification of an alternative splice variant."
    Page N.M., Butlin D.J., Lomthaisong K., Lowry P.J.
    Placenta 22:681-687(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), TISSUE SPECIFICITY.
  3. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
  6. Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 20-1791 (ISOFORM 1).
    Tissue: Placenta.

Entry informationi

Entry nameiPAPP2_HUMAN
AccessioniPrimary (citable) accession number: Q9BXP8
Secondary accession number(s): A9Z1Y8
, Q96PH7, Q96PH8, Q9H4C9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 7, 2004
Last sequence update: February 20, 2007
Last modified: November 26, 2014
This is version 121 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Peptidase families
    Classification of peptidase families and list of entries
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3