Q9BXP5 (SRRT_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Serrate RNA effector molecule homolog

Alternative name(s):
Arsenite-resistance protein 2

Gene names

Name:	SRRT
Synonyms:	ARS2, ASR2

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	876 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Acts as a mediator between the cap-binding complex (CBC) and the primary microRNAs (miRNAs) processing machinery during cell proliferation. Contributes to the stability and delivery of capped primary miRNA transcripts to the primary miRNA processing complex containing DGCR8 and DROSHA, thereby playing a role in RNA-mediated gene silencing (RNAi) by miRNAs. Binds capped RNAs (m7GpppG-capped RNA); however interaction is probably mediated via its interaction with NCBP1/CBP80 component of the CBC complex. Involved in cell cycle progression at S phase. Does not directly confer arsenite resistance but rather modulates arsenic sensitivity. Ref.19
Subunit structure	Interacts with NCBP1 and DROSHA By similarity. Interacts with CASP8AP2 and ERBB4. Ref.20 Ref.22
Subcellular location	Nucleus › nucleoplasm By similarity. Cytoplasm By similarity. Note: Predominantly nuclear. Shuttles between the nucleus and the cytoplasm in a CRM1-dependent way By similarity. Ref.22
Tissue specificity	Ubiquitously expressed. Ref.17
Sequence similarities	Belongs to the ARS2 family.
Sequence caution	The sequence AAD17774.1 differs from that shown. Reason: Erroneous initiation. The sequence AAM00189.1 differs from that shown. Reason: Frameshift at position 102. The sequence BAG58876.1 differs from that shown. Reason: Erroneous initiation. The sequence EAL23816.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
Biological process	RNA-mediated gene silencing
Cellular component	Cytoplasm Nucleus
Coding sequence diversity	Alternative splicing
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	cell proliferation Inferred from sequence or structural similarity. Source: UniProtKB primary miRNA processing Inferred from mutant phenotype Ref.19. Source: UniProtKB response to arsenic-containing substance Non-traceable author statement Ref.1. Source: UniProtKB
Cellular component	cytoplasm Inferred from sequence or structural similarity. Source: UniProtKB nucleoplasm Inferred from sequence or structural similarity. Source: UniProtKB
Molecular function	protein binding Inferred from physical interaction Ref.22. Source: UniProtKB
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
RNPS1	Q15287	1	EBI-712721,EBI-395959

Alternative products

This entry describes 5 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9BXP5-1)

Also known as: A;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9BXP5-2)

Also known as: B;

The sequence of this isoform differs from the canonical sequence as follows:
     776-780: ILPPG → S

Isoform 3 (identifier: Q9BXP5-3)

The sequence of this isoform differs from the canonical sequence as follows:
     388-388: Missing.

Isoform 4 (identifier: Q9BXP5-4)

The sequence of this isoform differs from the canonical sequence as follows:
     388-388: Missing.
     776-780: ILPPG → S

Isoform 5 (identifier: Q9BXP5-5)

The sequence of this isoform differs from the canonical sequence as follows:
     196-231: Missing.
     387-387: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 876	876	Serrate RNA effector molecule homolog		PRO_0000220965
Regions
	Compositional bias	10 – 82	73	Arg-rich
	Compositional bias	258 – 402	145	Glu-rich
	Compositional bias	760 – 828	69	Pro-rich
Amino acid modifications
	Modified residue	8	1	Phosphotyrosine Ref.11
	Modified residue	67	1	Phosphoserine Ref.11
	Modified residue	74	1	Phosphoserine Ref.11
	Modified residue	136	1	Phosphoserine Ref.18 Ref.21
	Modified residue	493	1	Phosphoserine Ref.11 Ref.16 Ref.18
	Modified residue	540	1	Phosphoserine Ref.13 Ref.18 Ref.21
	Modified residue	544	1	Phosphothreonine Ref.10 Ref.11 Ref.14 Ref.15 Ref.18 Ref.21
	Modified residue	624	1	Phosphotyrosine Ref.12
	Modified residue	625	1	Phosphotyrosine Ref.12
Natural variations
	Alternative sequence	196 – 231	36	Missing in isoform 5.		VSP_038122
	Alternative sequence	387	1	Missing in isoform 5.		VSP_038123
	Alternative sequence	388	1	Missing in isoform 3 and isoform 4.		VSP_032502
	Alternative sequence	776 – 780	5	ILPPG → S in isoform 2 and isoform 4.		VSP_000324
Experimental info
	Sequence conflict	106	1	G → GG in CAB46374. Ref.3
	Sequence conflict	119	1	D → E in AAM00189. Ref.2
	Sequence conflict	303	1	N → Y in AAM00189. Ref.2
	Sequence conflict	311	1	D → Y in BAG64018. Ref.4
	Sequence conflict	443	1	R → K in BAG64018. Ref.4
	Sequence conflict	498	1	R → W in CAB46374. Ref.3
	Sequence conflict	728	1	V → A in CAB46374. Ref.3
	Sequence conflict	744	1	K → R in CAB46374. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (A) [UniParc]. Last modified June 1, 2001. Version 1. Checksum: EB3ABD1325EA98D9	FASTA	876	100,666
	10 20 30 40 50 60 MGDSDDEYDR RRRDKFRRER SDYDRSRERD ERRRGDDWND REWDRGRERR SRGEYRDYDR 70 80 90 100 110 120 NRRERFSPPR HELSPPQKRM RRDWDEHSSD PYHSGYEMPY AGGGGGPTYG PPQPWGHPDV 130 140 150 160 170 180 HIMQHHVLPI QARLGSIAEI DLGVPPPVMK TFKEFLLSLD DSVDETEAVK RYNDYKLDFR 190 200 210 220 230 240 RQQMQDFFLA HKDEEWFRSK YHPDEVGKRR QEARGALQNR LRVFLSLMET GWFDNLLLDI 250 260 270 280 290 300 DKADAIVKML DAAVIKMEGG TENDLRILEQ EEEEEQAGKP GEPSKKEEGR AGAGLGDGER 310 320 330 340 350 360 KTNDKDEKKE DGKQAENDSS NDDKTKKSEG DGDKEEKKED SEKEAKKSSK KRNRKHSGDD 370 380 390 400 410 420 SFDEGSVSES ESESESGQAE EEKEEAEEAL KEKEKPKEEE WEKPKDAAGL ECKPRPLHKT 430 440 450 460 470 480 CSLFMRNIAP NISRAEIISL CKRYPGFMRV ALSEPQPERR FFRRGWVTFD RSVNIKEICW 490 500 510 520 530 540 NLQNIRLREC ELSPGVNRDL TRRVRNINGI TQHKQIVRND IKLAAKLIHT LDDRTQLWAS 550 560 570 580 590 600 EPGTPPLPTS LPSQNPILKN ITDYLIEEVS AEEEELLGSS GGAPPEEPPK EGNPAEINVE 610 620 630 640 650 660 RDEKLIKVLD KLLLYLRIVH SLDYYNTCEY PNEDEMPNRC GIIHVRGPMP PNRISHGEVL 670 680 690 700 710 720 EWQKTFEEKL TPLLSVRESL SEEEAQKMGR KDPEQEVEKF VTSNTQELGK DKWLCPLSGK 730 740 750 760 770 780 KFKGPEFVRK HIFNKHAEKI EEVKKEVAFF NNFLTDAKRP ALPEIKPAQP PGPAQILPPG 790 800 810 820 830 840 LTPGLPYPHQ TPQGLMPYGQ PRPPILGYGA GAVRPAVPTG GPPYPHAPYG AGRGNYDAFR 850 860 870 GQGGYPGKPR NRMVRGDPRA IVEYRDLDAP DDVDFF
	Isoform 2 (B) [UniParc]. Checksum: 371E6A555F1AADBB	FASTA	872	100,276
	10 20 30 40 50 60 MGDSDDEYDR RRRDKFRRER SDYDRSRERD ERRRGDDWND REWDRGRERR SRGEYRDYDR 70 80 90 100 110 120 NRRERFSPPR HELSPPQKRM RRDWDEHSSD PYHSGYEMPY AGGGGGPTYG PPQPWGHPDV 130 140 150 160 170 180 HIMQHHVLPI QARLGSIAEI DLGVPPPVMK TFKEFLLSLD DSVDETEAVK RYNDYKLDFR 190 200 210 220 230 240 RQQMQDFFLA HKDEEWFRSK YHPDEVGKRR QEARGALQNR LRVFLSLMET GWFDNLLLDI 250 260 270 280 290 300 DKADAIVKML DAAVIKMEGG TENDLRILEQ EEEEEQAGKP GEPSKKEEGR AGAGLGDGER 310 320 330 340 350 360 KTNDKDEKKE DGKQAENDSS NDDKTKKSEG DGDKEEKKED SEKEAKKSSK KRNRKHSGDD 370 380 390 400 410 420 SFDEGSVSES ESESESGQAE EEKEEAEEAL KEKEKPKEEE WEKPKDAAGL ECKPRPLHKT 430 440 450 460 470 480 CSLFMRNIAP NISRAEIISL CKRYPGFMRV ALSEPQPERR FFRRGWVTFD RSVNIKEICW 490 500 510 520 530 540 NLQNIRLREC ELSPGVNRDL TRRVRNINGI TQHKQIVRND IKLAAKLIHT LDDRTQLWAS 550 560 570 580 590 600 EPGTPPLPTS LPSQNPILKN ITDYLIEEVS AEEEELLGSS GGAPPEEPPK EGNPAEINVE 610 620 630 640 650 660 RDEKLIKVLD KLLLYLRIVH SLDYYNTCEY PNEDEMPNRC GIIHVRGPMP PNRISHGEVL 670 680 690 700 710 720 EWQKTFEEKL TPLLSVRESL SEEEAQKMGR KDPEQEVEKF VTSNTQELGK DKWLCPLSGK 730 740 750 760 770 780 KFKGPEFVRK HIFNKHAEKI EEVKKEVAFF NNFLTDAKRP ALPEIKPAQP PGPAQSLTPG 790 800 810 820 830 840 LPYPHQTPQG LMPYGQPRPP ILGYGAGAVR PAVPTGGPPY PHAPYGAGRG NYDAFRGQGG 850 860 870 YPGKPRNRMV RGDPRAIVEY RDLDAPDDVD FF
	Isoform 3 [UniParc]. Checksum: DC5CB52638E5A1E4	FASTA	875	100,537
	10 20 30 40 50 60 MGDSDDEYDR RRRDKFRRER SDYDRSRERD ERRRGDDWND REWDRGRERR SRGEYRDYDR 70 80 90 100 110 120 NRRERFSPPR HELSPPQKRM RRDWDEHSSD PYHSGYEMPY AGGGGGPTYG PPQPWGHPDV 130 140 150 160 170 180 HIMQHHVLPI QARLGSIAEI DLGVPPPVMK TFKEFLLSLD DSVDETEAVK RYNDYKLDFR 190 200 210 220 230 240 RQQMQDFFLA HKDEEWFRSK YHPDEVGKRR QEARGALQNR LRVFLSLMET GWFDNLLLDI 250 260 270 280 290 300 DKADAIVKML DAAVIKMEGG TENDLRILEQ EEEEEQAGKP GEPSKKEEGR AGAGLGDGER 310 320 330 340 350 360 KTNDKDEKKE DGKQAENDSS NDDKTKKSEG DGDKEEKKED SEKEAKKSSK KRNRKHSGDD 370 380 390 400 410 420 SFDEGSVSES ESESESGQAE EEKEEAEALK EKEKPKEEEW EKPKDAAGLE CKPRPLHKTC 430 440 450 460 470 480 SLFMRNIAPN ISRAEIISLC KRYPGFMRVA LSEPQPERRF FRRGWVTFDR SVNIKEICWN 490 500 510 520 530 540 LQNIRLRECE LSPGVNRDLT RRVRNINGIT QHKQIVRNDI KLAAKLIHTL DDRTQLWASE 550 560 570 580 590 600 PGTPPLPTSL PSQNPILKNI TDYLIEEVSA EEEELLGSSG GAPPEEPPKE GNPAEINVER 610 620 630 640 650 660 DEKLIKVLDK LLLYLRIVHS LDYYNTCEYP NEDEMPNRCG IIHVRGPMPP NRISHGEVLE 670 680 690 700 710 720 WQKTFEEKLT PLLSVRESLS EEEAQKMGRK DPEQEVEKFV TSNTQELGKD KWLCPLSGKK 730 740 750 760 770 780 FKGPEFVRKH IFNKHAEKIE EVKKEVAFFN NFLTDAKRPA LPEIKPAQPP GPAQILPPGL 790 800 810 820 830 840 TPGLPYPHQT PQGLMPYGQP RPPILGYGAG AVRPAVPTGG PPYPHAPYGA GRGNYDAFRG 850 860 870 QGGYPGKPRN RMVRGDPRAI VEYRDLDAPD DVDFF
	Isoform 4 [UniParc]. Checksum: 2A1153687E90090B	FASTA	871	100,147
	10 20 30 40 50 60 MGDSDDEYDR RRRDKFRRER SDYDRSRERD ERRRGDDWND REWDRGRERR SRGEYRDYDR 70 80 90 100 110 120 NRRERFSPPR HELSPPQKRM RRDWDEHSSD PYHSGYEMPY AGGGGGPTYG PPQPWGHPDV 130 140 150 160 170 180 HIMQHHVLPI QARLGSIAEI DLGVPPPVMK TFKEFLLSLD DSVDETEAVK RYNDYKLDFR 190 200 210 220 230 240 RQQMQDFFLA HKDEEWFRSK YHPDEVGKRR QEARGALQNR LRVFLSLMET GWFDNLLLDI 250 260 270 280 290 300 DKADAIVKML DAAVIKMEGG TENDLRILEQ EEEEEQAGKP GEPSKKEEGR AGAGLGDGER 310 320 330 340 350 360 KTNDKDEKKE DGKQAENDSS NDDKTKKSEG DGDKEEKKED SEKEAKKSSK KRNRKHSGDD 370 380 390 400 410 420 SFDEGSVSES ESESESGQAE EEKEEAEALK EKEKPKEEEW EKPKDAAGLE CKPRPLHKTC 430 440 450 460 470 480 SLFMRNIAPN ISRAEIISLC KRYPGFMRVA LSEPQPERRF FRRGWVTFDR SVNIKEICWN 490 500 510 520 530 540 LQNIRLRECE LSPGVNRDLT RRVRNINGIT QHKQIVRNDI KLAAKLIHTL DDRTQLWASE 550 560 570 580 590 600 PGTPPLPTSL PSQNPILKNI TDYLIEEVSA EEEELLGSSG GAPPEEPPKE GNPAEINVER 610 620 630 640 650 660 DEKLIKVLDK LLLYLRIVHS LDYYNTCEYP NEDEMPNRCG IIHVRGPMPP NRISHGEVLE 670 680 690 700 710 720 WQKTFEEKLT PLLSVRESLS EEEAQKMGRK DPEQEVEKFV TSNTQELGKD KWLCPLSGKK 730 740 750 760 770 780 FKGPEFVRKH IFNKHAEKIE EVKKEVAFFN NFLTDAKRPA LPEIKPAQPP GPAQSLTPGL 790 800 810 820 830 840 PYPHQTPQGL MPYGQPRPPI LGYGAGAVRP AVPTGGPPYP HAPYGAGRGN YDAFRGQGGY 850 860 870 PGKPRNRMVR GDPRAIVEYR DLDAPDDVDF F
	Isoform 5 [UniParc]. Checksum: DD73F667E8ADFB67	FASTA	839	96,222
	10 20 30 40 50 60 MGDSDDEYDR RRRDKFRRER SDYDRSRERD ERRRGDDWND REWDRGRERR SRGEYRDYDR 70 80 90 100 110 120 NRRERFSPPR HELSPPQKRM RRDWDEHSSD PYHSGYEMPY AGGGGGPTYG PPQPWGHPDV 130 140 150 160 170 180 HIMQHHVLPI QARLGSIAEI DLGVPPPVMK TFKEFLLSLD DSVDETEAVK RYNDYKLDFR 190 200 210 220 230 240 RQQMQDFFLA HKDEEWFDNL LLDIDKADAI VKMLDAAVIK MEGGTENDLR ILEQEEEEEQ 250 260 270 280 290 300 AGKPGEPSKK EEGRAGAGLG DGERKTNDKD EKKEDGKQAE NDSSNDDKTK KSEGDGDKEE 310 320 330 340 350 360 KKEDSEKEAK KSSKKRNRKH SGDDSFDEGS VSESESESES GQAEEEKEEA EALKEKEKPK 370 380 390 400 410 420 EEEWEKPKDA AGLECKPRPL HKTCSLFMRN IAPNISRAEI ISLCKRYPGF MRVALSEPQP 430 440 450 460 470 480 ERRFFRRGWV TFDRSVNIKE ICWNLQNIRL RECELSPGVN RDLTRRVRNI NGITQHKQIV 490 500 510 520 530 540 RNDIKLAAKL IHTLDDRTQL WASEPGTPPL PTSLPSQNPI LKNITDYLIE EVSAEEEELL 550 560 570 580 590 600 GSSGGAPPEE PPKEGNPAEI NVERDEKLIK VLDKLLLYLR IVHSLDYYNT CEYPNEDEMP 610 620 630 640 650 660 NRCGIIHVRG PMPPNRISHG EVLEWQKTFE EKLTPLLSVR ESLSEEEAQK MGRKDPEQEV 670 680 690 700 710 720 EKFVTSNTQE LGKDKWLCPL SGKKFKGPEF VRKHIFNKHA EKIEEVKKEV AFFNNFLTDA 730 740 750 760 770 780 KRPALPEIKP AQPPGPAQIL PPGLTPGLPY PHQTPQGLMP YGQPRPPILG YGAGAVRPAV 790 800 810 820 830 PTGGPPYPHA PYGAGRGNYD AFRGQGGYPG KPRNRMVRGD PRAIVEYRDL DAPDDVDFF

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Comparative analysis of the gene-dense ACHE/TFR2 region on human chromosome 7q22 with the orthologous region on mouse chromosome 5." Wilson M.D., Riemer C., Martindale D.W., Schnupf P., Boright A.P., Cheung T.L., Hardy D.M., Schwartz S., Scherer S.W., Tsui L.-C., Miller W., Koop B.F. Nucleic Acids Res. 29:1352-1365(2001) [PubMed: 11239002] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], ALTERNATIVE SPLICING (ISOFORMS 1 AND 2).
[2]	"Cloning and bioinformatic characterization of the full length human homologous asr2 gene." Yang L., Huang J., Ying K., Pan Z.M., Gu Y.Q., Wang G.Q., Lin S., Wu H., Yang Q.S., Xie Y., Mao Y.M. Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
[3]	"Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs." Wiemann S., Weil B., Wellenreuther R., Gassenhuber J., Glassl S., Ansorge W., Boecher M., Bloecker H., Bauersachs S., Blum H., Lauber J., Duesterhoeft A., Beyer A., Koehrer K., Strack N., Mewes H.-W., Ottenwaelder B., Obermaier B. , Tampe J., Heubner D., Wambutt R., Korn B., Klein M., Poustka A. Genome Res. 11:422-435(2001) [PubMed: 11230166] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3). Tissue: Brain.
[4]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5). Tissue: Testis and Thalamus.
[5]	"The DNA sequence of human chromosome 7." Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L. , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K. Nature 424:157-164(2003) [PubMed: 12853948] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"Human chromosome 7: DNA sequence and biology." Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S. , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C. Science 300:767-772(2003) [PubMed: 12690205] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[8]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 65-876 (ISOFORM 1). Tissue: Brain and Kidney.
[9]	Hu G. Submitted (AUG-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 443-876 (ISOFORMS 2/3).
[10]	"Large-scale characterization of HeLa cell nuclear phosphoproteins." Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J., Li J., Cohn M.A., Cantley L.C., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004) [PubMed: 15302935] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-544, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[11]	"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M. Cell 127:635-648(2006) [PubMed: 17081983] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-8; SER-67; SER-74; SER-493 AND THR-544, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[12]	"Tyrosine phosphorylated Par3 regulates epithelial tight junction assembly promoted by EGFR signaling." Wang Y., Du D., Fang L., Yang G., Zhang C., Zeng R., Ullrich A., Lottspeich F., Chen Z. EMBO J. 25:5058-5070(2006) [PubMed: 17053785] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-624 AND TYR-625, MASS SPECTROMETRY. Tissue: Embryonic kidney.
[13]	"A probability-based approach for high-throughput protein phosphorylation analysis and site localization." Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P. Nat. Biotechnol. 24:1285-1292(2006) [PubMed: 16964243] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-540, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[14]	"Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra." Yu L.-R., Zhu Z., Chan K.C., Issaq H.J., Dimitrov D.S., Veenstra T.D. J. Proteome Res. 6:4150-4162(2007) [PubMed: 17924679] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-544, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[15]	"Quantitative phosphoproteome profiling of Wnt3a-mediated signaling network: indicating the involvement of ribonucleoside-diphosphate reductase M2 subunit phosphorylation at residue serine 20 in canonical Wnt signal transduction." Tang L.-Y., Deng N., Wang L.-S., Dai J., Wang Z.-L., Jiang X.-S., Li S.-J., Li L., Sheng Q.-H., Wu D.-Q., Li L., Zeng R. Mol. Cell. Proteomics 6:1952-1967(2007) [PubMed: 17693683] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-544, MASS SPECTROMETRY. Tissue: Embryonic kidney.
[16]	"Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis." Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III J. Proteome Res. 7:1346-1351(2008) [PubMed: 18220336] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-493, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[17]	"ARS2 is a conserved eukaryotic gene essential for early mammalian development." Wilson M.D., Wang D., Wagner R., Breyssens H., Gertsenstein M., Lobe C., Lu X., Nagy A., Burke R.D., Koop B.F., Howard P.L. Mol. Cell. Biol. 28:1503-1514(2008) [PubMed: 18086880] [Abstract] Cited for: TISSUE SPECIFICITY.
[18]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-136; SER-493; SER-540 AND THR-544, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[19]	"Ars2 links the nuclear cap-binding complex to RNA interference and cell proliferation." Gruber J.J., Zatechka D.S., Sabin L.R., Yong J., Lum J.J., Kong M., Zong W.-X., Zhang Z., Lau C.-K., Rawlings J., Cherry S., Ihle J.N., Dreyfuss G., Thompson C.B. Cell 138:328-339(2009) [PubMed: 19632182] [Abstract] Cited for: FUNCTION.
[20]	"Interaction of FLASH with arsenite resistance protein 2 is involved in cell cycle progression at S phase." Kiriyama M., Kobayashi Y., Saito M., Ishikawa F., Yonehara S. Mol. Cell. Biol. 29:4729-4741(2009) [PubMed: 19546234] [Abstract] Cited for: INTERACTION WITH CASP8AP2.
[21]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed: 19690332] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-136; SER-540 AND THR-544, MASS SPECTROMETRY. Tissue: Leukemic T-cell.
[22]	"Interactions of ErbB4 and Kap1 connect the growth factor and DNA damage response pathways." Gilmore-Hebert M., Ramabhadran R., Stern D.F. Mol. Cancer Res. 8:1388-1398(2010) [PubMed: 20858735] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY, INTERACTION WITH ERBB4, SUBCELLULAR LOCATION.
[23]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed: 21269460] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF312032 Genomic DNA. Translation: AAK21005.1. AF312032 Genomic DNA. Translation: AAK21006.1. AF248955 mRNA. Translation: AAM00189.1. Frameshift. AL096723 mRNA. Translation: CAB46374.2. AK296131 mRNA. Translation: BAG58876.1. Different initiation. AK302820 mRNA. Translation: BAG64018.1. AC011895 Genomic DNA. No translation available. CH236956 Genomic DNA. Translation: EAL23815.1. CH236956 Genomic DNA. Translation: EAL23816.1. Sequence problems. CH471091 Genomic DNA. Translation: EAW76467.1. BC000082 mRNA. Translation: AAH00082.2. BC069249 mRNA. Translation: AAH69249.1. BC109117 mRNA. Translation: AAI09118.1. AF082871 mRNA. Translation: AAD17774.1. Different initiation.
IPI	IPI00220038. IPI00375144. IPI00888085. IPI00888510. IPI00927582.
PIR	T12455.
RefSeq	NP_001122324.1. NM_001128852.1. NP_001122325.1. NM_001128853.1. NP_001122326.1. NM_001128854.1. NP_056992.4. NM_015908.5.
UniGene	Hs.111801.
3D structure databases
ProteinModelPortal	Q9BXP5.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9BXP5. 12 interactions.
MINT	MINT-1373887.
STRING	Q9BXP5.
PTM databases
PhosphoSite	Q9BXP5.
Polymorphism databases
DMDM	20137457.
Proteomic databases
PRIDE	Q9BXP5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000347433; ENSP00000314491; ENSG00000087087. ENST00000388793; ENSP00000373445; ENSG00000087087. ENST00000457580; ENSP00000416553; ENSG00000087087.
GeneID	51593.
KEGG	hsa:51593.
UCSC	uc003uwy.2. human. uc003uwz.2. human. uc003uxa.2. human.
Organism-specific databases
CTD	51593.
GeneCards	GC07P100472.
HGNC	HGNC:24101. SRRT.
neXtProt	NX_Q9BXP5.
PharmGKB	PA164726295.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG05613.
GeneTree	ENSGT00390000005492.
InParanoid	Q9BXP5.
OMA	IRKHIFN.
OrthoDB	EOG4N30NP.
PhylomeDB	Q9BXP5.
Gene expression databases
ArrayExpress	Q9BXP5.
Bgee	Q9BXP5.
Genevestigator	Q9BXP5.
GermOnline	ENSG00000087087. Homo sapiens.
Family and domain databases
InterPro	IPR007042. Arsenite-R_2. IPR021933. DUF3546. [Graphical view]
Pfam	PF04959. ARS2. 1 hit. PF12066. DUF3546. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	55439.

Entry information

Entry name

SRRT_HUMAN

Accession

Primary (citable) accession number: Q9BXP5
Secondary accession number(s): A4D2E5 , A4D2E6, A6NK22, B4DJL4, B4DZA6, O95808, Q32MI4, Q6NT74, Q8TDQ5, Q9BWP6, Q9BXP4, Q9Y4S4

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 23, 2002
Last sequence update:	June 1, 2001
Last modified:	January 25, 2012
This is version 87 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.