Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Sperm protein associated with the nucleus on the X chromosome D

Gene

SPANXD

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Sperm protein associated with the nucleus on the X chromosome DCurated
Alternative name(s):
Cancer/testis antigen 11.4
Short name:
CT11.4
Nuclear-associated protein SPAN-Xd
Short name:
SPANX-DImported
SPANX family member DImported
Gene namesi
Name:SPANXDImported
Synonyms:SPANXEImported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:14332. SPANXD.

Subcellular locationi

  • Cytoplasm By similarity
  • Nucleus By similarity

  • Note: Associated with nuclear craters.By similarity

GO - Cellular componenti

  • cytoplasm Source: UniProtKB-SubCell
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37874.

Polymorphism and mutation databases

BioMutaiSPANXD.
DMDMi85543355.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 9797Sperm protein associated with the nucleus on the X chromosome DPRO_0000189552Add
BLAST

Proteomic databases

EPDiQ9BXN6.
PaxDbiQ9BXN6.
PRIDEiQ9BXN6.

PTM databases

iPTMnetiQ9BXN6.

Expressioni

Tissue specificityi

Detected in testis, sperm and a melanoma cell line.1 Publication

Developmental stagei

Detected in round and elongating spermatids.1 Publication

Gene expression databases

BgeeiQ9BXN6.
CleanExiHS_SPANXD.

Organism-specific databases

HPAiHPA046423.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
SETBP1Q9Y6X03EBI-10301202,EBI-2548259

Protein-protein interaction databases

BioGridi122224. 1 interaction.
IntActiQ9BXN6. 1 interaction.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi37 – 459Nuclear localization signalSequence analysis

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi83 – 864Poly-Glu

Sequence similaritiesi

Belongs to the SPAN-X family.Curated

Phylogenomic databases

eggNOGiENOG410KCE0. Eukaryota.
ENOG4110P2D. LUCA.
GeneTreeiENSGT00730000111796.
HOGENOMiHOG000015252.
HOVERGENiHBG059401.
InParanoidiQ9BXN6.
OrthoDBiEOG7N901P.
PhylomeDBiQ9BXN6.
TreeFamiTF341404.

Family and domain databases

InterProiIPR010007. SPAN-X_fam.
[Graphical view]
PANTHERiPTHR23425. PTHR23425. 1 hit.
PfamiPF07458. SPAN-X. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9BXN6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDKQSSAGGV KRSVPCDSNE ANEMMPETSS GYSDPQPAPK KLKTSESSTI
60 70 80 90
LVVRYRRNFK RTSPEELVND HARKNRINPL QMEEEEFMEI MVEIPAK
Length:97
Mass (Da):11,029
Last modified:June 1, 2001 - v1
Checksum:i33EDEC18FF9F96D1
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti68 – 681V → L.
Corresponds to variant rs5953618 [ dbSNP | Ensembl ].
VAR_034516

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF312765 mRNA. Translation: AAK28485.1.
AJ457791 Genomic DNA. Translation: CAD29840.1.
AY920931 Genomic DNA. Translation: AAY18634.1.
AY920933 Genomic DNA. Translation: AAY18636.1.
AY920934 Genomic DNA. Translation: AAY18637.1.
AY920935 Genomic DNA. Translation: AAY18638.1.
AY920936 Genomic DNA. Translation: AAY18639.1.
AY920937 Genomic DNA. Translation: AAY18640.1.
AY920939 Genomic DNA. Translation: AAY18642.1.
AY920940 Genomic DNA. Translation: AAY18643.1.
AY920941 Genomic DNA. Translation: AAY18644.1.
AY920942 Genomic DNA. Translation: AAY18645.1.
AY920943 Genomic DNA. Translation: AAY18646.1.
AY920944 Genomic DNA. Translation: AAY18647.1.
AY920945 Genomic DNA. Translation: AAY18648.1.
AY920946 Genomic DNA. Translation: AAY18649.1.
AY920947 Genomic DNA. Translation: AAY18650.1.
AY920948 Genomic DNA. Translation: AAY18651.1.
AY920949 Genomic DNA. Translation: AAY18652.1.
AY920950 Genomic DNA. Translation: AAY18653.1.
AY920951 Genomic DNA. Translation: AAY18654.1.
AY920952 Genomic DNA. Translation: AAY18655.1.
AY920953 Genomic DNA. Translation: AAY18656.1.
AY920954 Genomic DNA. Translation: AAY18657.1.
AY920955 Genomic DNA. Translation: AAY18658.1.
AY920956 Genomic DNA. Translation: AAY18659.1.
AY920957 Genomic DNA. Translation: AAY18660.1.
AY920958 Genomic DNA. Translation: AAY18661.1.
AY920959 Genomic DNA. Translation: AAY18662.1.
AY920960 Genomic DNA. Translation: AAY18663.1.
AY920961 Genomic DNA. Translation: AAY18664.1.
AY920962 Genomic DNA. Translation: AAY18665.1.
AY920963 Genomic DNA. Translation: AAY18666.1.
AY920965 Genomic DNA. Translation: AAY18668.1.
AY920966 Genomic DNA. Translation: AAY18669.1.
AY920967 Genomic DNA. Translation: AAY18670.1.
AY920968 Genomic DNA. Translation: AAY18671.1.
AY920969 Genomic DNA. Translation: AAY18672.1.
AY920970 Genomic DNA. Translation: AAY18673.1.
AY920971 Genomic DNA. Translation: AAY18674.1.
AY920972 Genomic DNA. Translation: AAY18675.1.
AY920973 Genomic DNA. Translation: AAY18676.1.
AY920974 Genomic DNA. Translation: AAY18677.1.
AY920975 Genomic DNA. Translation: AAY18678.1.
AY920976 Genomic DNA. Translation: AAY18679.1.
AY920977 Genomic DNA. Translation: AAY18680.1.
AY920978 Genomic DNA. Translation: AAY18681.1.
AY920979 Genomic DNA. Translation: AAY18682.1.
AY920980 Genomic DNA. Translation: AAY18683.1.
AY920981 Genomic DNA. Translation: AAY18684.1.
AY920982 Genomic DNA. Translation: AAY18685.1.
AY920985 Genomic DNA. Translation: AAY18688.1.
AY920986 Genomic DNA. Translation: AAY18689.1.
AY920987 Genomic DNA. Translation: AAY18690.1.
AL121881 Genomic DNA. Translation: CAI42368.1.
BC103961 mRNA. Translation: AAI03962.1.
BC121070 mRNA. Translation: AAI21071.1.
BC134418 mRNA. Translation: AAI34419.1.
CCDSiCCDS14675.1.
RefSeqiNP_115793.1. NM_032417.3.
UniGeneiHs.375036.

Genome annotation databases

EnsembliENST00000370515; ENSP00000359546; ENSG00000196406.
GeneIDi64648.
KEGGihsa:64648.
UCSCiuc004fbq.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF312765 mRNA. Translation: AAK28485.1.
AJ457791 Genomic DNA. Translation: CAD29840.1.
AY920931 Genomic DNA. Translation: AAY18634.1.
AY920933 Genomic DNA. Translation: AAY18636.1.
AY920934 Genomic DNA. Translation: AAY18637.1.
AY920935 Genomic DNA. Translation: AAY18638.1.
AY920936 Genomic DNA. Translation: AAY18639.1.
AY920937 Genomic DNA. Translation: AAY18640.1.
AY920939 Genomic DNA. Translation: AAY18642.1.
AY920940 Genomic DNA. Translation: AAY18643.1.
AY920941 Genomic DNA. Translation: AAY18644.1.
AY920942 Genomic DNA. Translation: AAY18645.1.
AY920943 Genomic DNA. Translation: AAY18646.1.
AY920944 Genomic DNA. Translation: AAY18647.1.
AY920945 Genomic DNA. Translation: AAY18648.1.
AY920946 Genomic DNA. Translation: AAY18649.1.
AY920947 Genomic DNA. Translation: AAY18650.1.
AY920948 Genomic DNA. Translation: AAY18651.1.
AY920949 Genomic DNA. Translation: AAY18652.1.
AY920950 Genomic DNA. Translation: AAY18653.1.
AY920951 Genomic DNA. Translation: AAY18654.1.
AY920952 Genomic DNA. Translation: AAY18655.1.
AY920953 Genomic DNA. Translation: AAY18656.1.
AY920954 Genomic DNA. Translation: AAY18657.1.
AY920955 Genomic DNA. Translation: AAY18658.1.
AY920956 Genomic DNA. Translation: AAY18659.1.
AY920957 Genomic DNA. Translation: AAY18660.1.
AY920958 Genomic DNA. Translation: AAY18661.1.
AY920959 Genomic DNA. Translation: AAY18662.1.
AY920960 Genomic DNA. Translation: AAY18663.1.
AY920961 Genomic DNA. Translation: AAY18664.1.
AY920962 Genomic DNA. Translation: AAY18665.1.
AY920963 Genomic DNA. Translation: AAY18666.1.
AY920965 Genomic DNA. Translation: AAY18668.1.
AY920966 Genomic DNA. Translation: AAY18669.1.
AY920967 Genomic DNA. Translation: AAY18670.1.
AY920968 Genomic DNA. Translation: AAY18671.1.
AY920969 Genomic DNA. Translation: AAY18672.1.
AY920970 Genomic DNA. Translation: AAY18673.1.
AY920971 Genomic DNA. Translation: AAY18674.1.
AY920972 Genomic DNA. Translation: AAY18675.1.
AY920973 Genomic DNA. Translation: AAY18676.1.
AY920974 Genomic DNA. Translation: AAY18677.1.
AY920975 Genomic DNA. Translation: AAY18678.1.
AY920976 Genomic DNA. Translation: AAY18679.1.
AY920977 Genomic DNA. Translation: AAY18680.1.
AY920978 Genomic DNA. Translation: AAY18681.1.
AY920979 Genomic DNA. Translation: AAY18682.1.
AY920980 Genomic DNA. Translation: AAY18683.1.
AY920981 Genomic DNA. Translation: AAY18684.1.
AY920982 Genomic DNA. Translation: AAY18685.1.
AY920985 Genomic DNA. Translation: AAY18688.1.
AY920986 Genomic DNA. Translation: AAY18689.1.
AY920987 Genomic DNA. Translation: AAY18690.1.
AL121881 Genomic DNA. Translation: CAI42368.1.
BC103961 mRNA. Translation: AAI03962.1.
BC121070 mRNA. Translation: AAI21071.1.
BC134418 mRNA. Translation: AAI34419.1.
CCDSiCCDS14675.1.
RefSeqiNP_115793.1. NM_032417.3.
UniGeneiHs.375036.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122224. 1 interaction.
IntActiQ9BXN6. 1 interaction.

PTM databases

iPTMnetiQ9BXN6.

Polymorphism and mutation databases

BioMutaiSPANXD.
DMDMi85543355.

Proteomic databases

EPDiQ9BXN6.
PaxDbiQ9BXN6.
PRIDEiQ9BXN6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000370515; ENSP00000359546; ENSG00000196406.
GeneIDi64648.
KEGGihsa:64648.
UCSCiuc004fbq.5. human.

Organism-specific databases

CTDi64648.
GeneCardsiSPANXD.
HGNCiHGNC:14332. SPANXD.
HPAiHPA046423.
MIMi300670. gene.
neXtProtiNX_Q9BXN6.
PharmGKBiPA37874.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410KCE0. Eukaryota.
ENOG4110P2D. LUCA.
GeneTreeiENSGT00730000111796.
HOGENOMiHOG000015252.
HOVERGENiHBG059401.
InParanoidiQ9BXN6.
OrthoDBiEOG7N901P.
PhylomeDBiQ9BXN6.
TreeFamiTF341404.

Miscellaneous databases

GenomeRNAii64648.
PROiQ9BXN6.
SOURCEiSearch...

Gene expression databases

BgeeiQ9BXN6.
CleanExiHS_SPANXD.

Family and domain databases

InterProiIPR010007. SPAN-X_fam.
[Graphical view]
PANTHERiPTHR23425. PTHR23425. 1 hit.
PfamiPF07458. SPAN-X. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The genes encoding the cancer testis associated protein SPAN-X exist as a multiple gene family."
    Westbrook V.A., Coppola M.A., Diekman A.B., Herr J.C.
    Submitted (OCT-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Testis.
  2. "The human SPANX multigene family: genomic organization, alignment and expression in male germ cells and tumor cell lines."
    Zendman A.J., Zschocke J., van Kraats A.A., de Wit N.J.W., Kurpisz M., Weidle U.H., Ruiter D.J., Weiss E.H., van Muijen G.N.P.
    Gene 309:125-133(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], DEVELOPMENTAL STAGE, TISSUE SPECIFICITY.
  3. "Dynamic structure of the SPANX gene cluster mapped to the prostate cancer susceptibility locus HPCX at Xq27."
    Kouprina N., Pavlicek A., Noskov V.N., Solomon G., Otstot J., Isaacs W., Carpten J.D., Trent J.M., Schleutker J., Barrett J.C., Jurka J., Larionov V.
    Genome Res. 15:1477-1486(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  4. "The DNA sequence of the human X chromosome."
    Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
    , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
    Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiSPNXD_HUMAN
AccessioniPrimary (citable) accession number: Q9BXN6
Secondary accession number(s): Q5JWI1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: June 1, 2001
Last modified: June 8, 2016
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.