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Protein

Sperm protein associated with the nucleus on the X chromosome D

Gene

SPANXD

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Sperm protein associated with the nucleus on the X chromosome DCurated
Alternative name(s):
Cancer/testis antigen 11.4
Short name:
CT11.4
Nuclear-associated protein SPAN-Xd
Short name:
SPANX-DImported
SPANX family member DImported
Gene namesi
Name:SPANXDImported
Synonyms:SPANXEImported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000196406.4
HGNCiHGNC:14332 SPANXD
MIMi300670 gene
neXtProtiNX_Q9BXN6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi64648
OpenTargetsiENSG00000196406
PharmGKBiPA37874

Polymorphism and mutation databases

BioMutaiSPANXD
DMDMi85543355

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001895521 – 97Sperm protein associated with the nucleus on the X chromosome DAdd BLAST97

Proteomic databases

MaxQBiQ9BXN6
PaxDbiQ9BXN6
PeptideAtlasiQ9BXN6
PRIDEiQ9BXN6
ProteomicsDBi79471

PTM databases

iPTMnetiQ9BXN6
PhosphoSitePlusiQ9BXN6

Expressioni

Tissue specificityi

Detected in testis, sperm and a melanoma cell line.1 Publication

Developmental stagei

Detected in round and elongating spermatids.1 Publication

Gene expression databases

BgeeiENSG00000196406
CleanExiHS_SPANXD

Organism-specific databases

HPAiHPA046423
HPA073647

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
SETBP1Q9Y6X03EBI-10301202,EBI-2548259

Protein-protein interaction databases

BioGridi122224, 3 interactors
IntActiQ9BXN6, 2 interactors
STRINGi9606.ENSP00000359546

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi37 – 45Nuclear localization signalSequence analysis9

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi83 – 86Poly-Glu4

Sequence similaritiesi

Belongs to the SPAN-X family.Curated

Phylogenomic databases

eggNOGiENOG410KCE0 Eukaryota
ENOG4110P2D LUCA
GeneTreeiENSGT00730000111796
HOGENOMiHOG000015252
HOVERGENiHBG059401
InParanoidiQ9BXN6
OrthoDBiEOG091G0PSU
PhylomeDBiQ9BXN6
TreeFamiTF341404

Family and domain databases

InterProiView protein in InterPro
IPR010007 SPAN-X_fam
PANTHERiPTHR23425 PTHR23425, 1 hit
PfamiView protein in Pfam
PF07458 SPAN-X, 1 hit

Sequencei

Sequence statusi: Complete.

Q9BXN6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDKQSSAGGV KRSVPCDSNE ANEMMPETSS GYSDPQPAPK KLKTSESSTI
60 70 80 90
LVVRYRRNFK RTSPEELVND HARKNRINPL QMEEEEFMEI MVEIPAK
Length:97
Mass (Da):11,029
Last modified:June 1, 2001 - v1
Checksum:i33EDEC18FF9F96D1
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03451668V → L. Corresponds to variant dbSNP:rs5953618Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF312765 mRNA Translation: AAK28485.1
AJ457791 Genomic DNA Translation: CAD29840.1
AY920931 Genomic DNA Translation: AAY18634.1
AY920933 Genomic DNA Translation: AAY18636.1
AY920934 Genomic DNA Translation: AAY18637.1
AY920935 Genomic DNA Translation: AAY18638.1
AY920936 Genomic DNA Translation: AAY18639.1
AY920937 Genomic DNA Translation: AAY18640.1
AY920939 Genomic DNA Translation: AAY18642.1
AY920940 Genomic DNA Translation: AAY18643.1
AY920941 Genomic DNA Translation: AAY18644.1
AY920942 Genomic DNA Translation: AAY18645.1
AY920943 Genomic DNA Translation: AAY18646.1
AY920944 Genomic DNA Translation: AAY18647.1
AY920945 Genomic DNA Translation: AAY18648.1
AY920946 Genomic DNA Translation: AAY18649.1
AY920947 Genomic DNA Translation: AAY18650.1
AY920948 Genomic DNA Translation: AAY18651.1
AY920949 Genomic DNA Translation: AAY18652.1
AY920950 Genomic DNA Translation: AAY18653.1
AY920951 Genomic DNA Translation: AAY18654.1
AY920952 Genomic DNA Translation: AAY18655.1
AY920953 Genomic DNA Translation: AAY18656.1
AY920954 Genomic DNA Translation: AAY18657.1
AY920955 Genomic DNA Translation: AAY18658.1
AY920956 Genomic DNA Translation: AAY18659.1
AY920957 Genomic DNA Translation: AAY18660.1
AY920958 Genomic DNA Translation: AAY18661.1
AY920959 Genomic DNA Translation: AAY18662.1
AY920960 Genomic DNA Translation: AAY18663.1
AY920961 Genomic DNA Translation: AAY18664.1
AY920962 Genomic DNA Translation: AAY18665.1
AY920963 Genomic DNA Translation: AAY18666.1
AY920965 Genomic DNA Translation: AAY18668.1
AY920966 Genomic DNA Translation: AAY18669.1
AY920967 Genomic DNA Translation: AAY18670.1
AY920968 Genomic DNA Translation: AAY18671.1
AY920969 Genomic DNA Translation: AAY18672.1
AY920970 Genomic DNA Translation: AAY18673.1
AY920971 Genomic DNA Translation: AAY18674.1
AY920972 Genomic DNA Translation: AAY18675.1
AY920973 Genomic DNA Translation: AAY18676.1
AY920974 Genomic DNA Translation: AAY18677.1
AY920975 Genomic DNA Translation: AAY18678.1
AY920976 Genomic DNA Translation: AAY18679.1
AY920977 Genomic DNA Translation: AAY18680.1
AY920978 Genomic DNA Translation: AAY18681.1
AY920979 Genomic DNA Translation: AAY18682.1
AY920980 Genomic DNA Translation: AAY18683.1
AY920981 Genomic DNA Translation: AAY18684.1
AY920982 Genomic DNA Translation: AAY18685.1
AY920985 Genomic DNA Translation: AAY18688.1
AY920986 Genomic DNA Translation: AAY18689.1
AY920987 Genomic DNA Translation: AAY18690.1
AL121881 Genomic DNA Translation: CAI42368.1
BC103961 mRNA Translation: AAI03962.1
BC121070 mRNA Translation: AAI21071.1
BC134418 mRNA Translation: AAI34419.1
CCDSiCCDS14675.1
RefSeqiNP_115793.1, NM_032417.3
UniGeneiHs.375036

Genome annotation databases

EnsembliENST00000370515; ENSP00000359546; ENSG00000196406
GeneIDi64648
KEGGihsa:64648
UCSCiuc004fbq.5 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiSPNXD_HUMAN
AccessioniPrimary (citable) accession number: Q9BXN6
Secondary accession number(s): Q5JWI1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: June 1, 2001
Last modified: June 20, 2018
This is version 103 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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