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Q9BXN1

- ASPN_HUMAN

UniProt

Q9BXN1 - ASPN_HUMAN

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Protein

Asporin

Gene

ASPN

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Negatively regulates periodontal ligament (PDL) differentiation and mineralization to ensure that the PDL is not ossified and to maintain homeostasis of the tooth-supporting system. Inhibits BMP2-induced cytodifferentiation of PDL cells by preventing its binding to BMPR1B/BMP type-1B receptor, resulting in inhibition of BMP-dependent activation of SMAD proteins (By similarity). Critical regulator of TGF-beta in articular cartilage and plays an essential role in cartilage homeostasis and osteoarthritis (OA) pathogenesis. Negatively regulates chondrogenesis in the articular cartilage by blocking the TGF-beta/receptor interaction on the cell surface and inhibiting the canonical TGF-beta/Smad signal. Binds calcium and plays a role in osteoblast-driven collagen biomineralization activity.By similarity2 Publications

GO - Molecular functioni

  1. calcium ion binding Source: UniProtKB

GO - Biological processi

  1. bone mineralization Source: UniProtKB
  2. negative regulation of tooth mineralization Source: UniProtKB
  3. negative regulation of transforming growth factor beta receptor signaling pathway Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Biomineralization

Keywords - Ligandi

Calcium

Enzyme and pathway databases

ReactomeiREACT_163906. ECM proteoglycans.

Names & Taxonomyi

Protein namesi
Recommended name:
Asporin
Alternative name(s):
Periodontal ligament-associated protein 1
Short name:
PLAP-1
Gene namesi
Name:ASPN
Synonyms:PLAP1, SLRR1C
ORF Names:UNQ215/PRO241
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 9

Organism-specific databases

HGNCiHGNC:14872. ASPN.

Subcellular locationi

Secretedextracellular spaceextracellular matrix 1 Publication

GO - Cellular componenti

  1. proteinaceous extracellular matrix Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

Pathology & Biotechi

Involvement in diseasei

Osteoarthritis 3 (OS3) [MIM:607850]: A degenerative disease of the joints characterized by degradation of the hyaline articular cartilage and remodeling of the subchondral bone with sclerosis. Clinical symptoms include pain and joint stiffness often leading to significant disability and joint replacement.
Note: Disease susceptibility is associated with variations affecting the gene represented in this entry. Susceptibility to osteoarthritis is conferred by a triplet repeat expansion polymorphism. ASPN allele having 14 aspartic acid repeats in the N-terminal region of the protein (D14), is overrepresented relative to the common allele having 13 aspartic acid repeats (D13). The frequency of the D14 allele increases with disease severity. The D14 allele is also overrepresented in individuals with hip osteoarthritis.
Intervertebral disc disease (IDD) [MIM:603932]: A common musculo-skeletal disorder caused by degeneration of intervertebral disks of the lumbar spine. It results in low-back pain and unilateral leg pain.1 Publication
Note: Disease susceptibility is associated with variations affecting the gene represented in this entry. Susceptibility to intervertebral disk disease, particularly lumbar disk degeneration, is conferred by a triplet repeat expansion polymorphism. ASPN allele having 14 aspartic acid repeats in the N-terminal region of the protein (D14), is associated with the disorder in some populations (PubMed:18304494).1 Publication

Organism-specific databases

MIMi603932. phenotype.
607850. phenotype.
PharmGKBiPA25057.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1414Sequence AnalysisAdd
BLAST
Propeptidei15 – 3218Sequence AnalysisPRO_0000032727Add
BLAST
Chaini33 – 380348AsporinPRO_0000032728Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi55 – 551O-linked (GalNAc...)1 Publication
Disulfide bondi75 ↔ 811 Publication
Disulfide bondi79 ↔ 881 Publication
Glycosylationi282 – 2821N-linked (GlcNAc...)2 Publications
Disulfide bondi333 ↔ 3661 Publication

Post-translational modificationi

There is no serine/glycine dipeptide sequence expected for the attachment of O-linked glycosaminoglycans and this is probably not a proteoglycan. The O-linked polysaccharide on 54-Ser is probably the mucin type linked to GalNAc.
The N-linked glycan at Asn-282 is composed of variable structures of GlcNAc, mannose, fucose, HexNAc and hexose.2 Publications

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9BXN1.
PRIDEiQ9BXN1.

PTM databases

PhosphoSiteiQ9BXN1.

Expressioni

Tissue specificityi

Higher levels in osteoarthritic articular cartilage, aorta, uterus. Moderate expression in small intestine, heart, liver, bladder, ovary, stomach, and in the adrenal, thyroid, and mammary glands. Low expression in trachea, bone marrow, and lung. Colocalizes with TGFB1 in chondrocytes within osteoarthritic (OA) lesions of articular cartilage.1 Publication

Inductioni

By TGFB1.1 Publication

Gene expression databases

BgeeiQ9BXN1.
CleanExiHS_ASPN.
ExpressionAtlasiQ9BXN1. baseline and differential.
GenevestigatoriQ9BXN1.

Organism-specific databases

HPAiHPA008435.
HPA024230.

Interactioni

Subunit structurei

Interacts with TGFB1, TGFB2 and TGFB3. DCN, BGN, and FMOD inhibit binding to TGFB1. Interacts with BMP2. Interacts in vitro with type II collagen (By similarity). Interacts with type I collagen. DCN can inhibit collagen binding.By similarity1 Publication

Protein-protein interaction databases

STRINGi9606.ENSP00000364694.

Structurei

3D structure databases

ProteinModelPortaliQ9BXN1.
SMRiQ9BXN1. Positions 74-377.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini66 – 10237LRRNTAdd
BLAST
Repeati103 – 12422LRR 1Add
BLAST
Repeati127 – 14822LRR 2Add
BLAST
Repeati151 – 17323LRR 3Add
BLAST
Repeati174 – 19320LRR 4Add
BLAST
Repeati196 – 21924LRR 5Add
BLAST
Repeati242 – 26322LRR 6Add
BLAST
Repeati266 – 28722LRR 7Add
BLAST
Repeati290 – 31223LRR 8Add
BLAST
Repeati313 – 33422LRR 9Add
BLAST
Repeati335 – 35723LRR 10Add
BLAST
Repeati358 – 38023LRR 11Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni166 – 21247Interaction with TGFB1By similarityAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi35 – 5319Poly-AspAdd
BLAST
Compositional biasi77 – 9014Cys-richAdd
BLAST

Domaini

The LRR 5 repeat can inhibit BMP2-induced cytodifferentiation and may be involved in the interaction with BMP2 (By similarity). The repeats LRR 10, LRR 11 and LRR 12 are involved in binding type I collagen. The poly-Asp region is involved in binding calcium.By similarity1 Publication

Sequence similaritiesi

Contains 11 LRR (leucine-rich) repeats.Curated
Contains 1 LRRNT domain.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal

Phylogenomic databases

eggNOGiCOG4886.
GeneTreeiENSGT00760000118969.
HOVERGENiHBG016052.
InParanoidiQ9BXN1.
KOiK08120.
OMAiEDFIRYK.
OrthoDBiEOG76739V.
PhylomeDBiQ9BXN1.
TreeFamiTF334562.

Family and domain databases

InterProiIPR028548. Asporin.
IPR001611. Leu-rich_rpt.
IPR000372. LRR-contain_N.
IPR016352. SLRP_I_decor/aspor/byglycan.
[Graphical view]
PANTHERiPTHR24369:SF10. PTHR24369:SF10. 1 hit.
PfamiPF13855. LRR_8. 3 hits.
PF01462. LRRNT. 1 hit.
[Graphical view]
PIRSFiPIRSF002490. SLRP_I. 1 hit.
SMARTiSM00013. LRRNT. 1 hit.
[Graphical view]
PROSITEiPS51450. LRR. 7 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9BXN1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKEYVLLLFL ALCSAKPFFS PSHIALKNMM LKDMEDTDDD DDDDDDDDDD
60 70 80 90 100
DEDNSLFPTR EPRSHFFPFD LFPMCPFGCQ CYSRVVHCSD LGLTSVPTNI
110 120 130 140 150
PFDTRMLDLQ NNKIKEIKEN DFKGLTSLYG LILNNNKLTK IHPKAFLTTK
160 170 180 190 200
KLRRLYLSHN QLSEIPLNLP KSLAELRIHE NKVKKIQKDT FKGMNALHVL
210 220 230 240 250
EMSANPLDNN GIEPGAFEGV TVFHIRIAEA KLTSVPKGLP PTLLELHLDY
260 270 280 290 300
NKISTVELED FKRYKELQRL GLGNNKITDI ENGSLANIPR VREIHLENNK
310 320 330 340 350
LKKIPSGLPE LKYLQIIFLH SNSIARVGVN DFCPTVPKMK KSLYSAISLF
360 370 380
NNPVKYWEMQ PATFRCVLSR MSVQLGNFGM
Length:380
Mass (Da):43,417
Last modified:October 14, 2008 - v2
Checksum:i2746A977FDCEBA5F
GO

Sequence cautioni

The sequence BAA90967.1 differs from that shown. Reason: Erroneous initiation.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti238 – 2436GLPPTL → DNLPSF in BAB55060. (PubMed:14702039)Curated

Polymorphismi

The poly-Asp region of ASPN is polymorphic and ranges at least from 11 to 17 Asp.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF316824 mRNA. Translation: AAK35161.1.
AY029191 mRNA. Translation: AAK31800.1.
AK000136 mRNA. Translation: BAA90967.1. Different initiation.
AK027359 mRNA. Translation: BAB55060.1.
AY358329 mRNA. Translation: AAQ88695.1.
AL137848 Genomic DNA. Translation: CAI16697.1.
CH471089 Genomic DNA. Translation: EAW62822.1.
RefSeqiNP_001180264.1. NM_001193335.1.
NP_060150.4. NM_017680.4.
UniGeneiHs.435655.

Genome annotation databases

EnsembliENST00000375544; ENSP00000364694; ENSG00000106819.
GeneIDi54829.
KEGGihsa:54829.
UCSCiuc004ase.2. human.

Polymorphism databases

DMDMi209572589.

Keywords - Coding sequence diversityi

Polymorphism, Triplet repeat expansion

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF316824 mRNA. Translation: AAK35161.1 .
AY029191 mRNA. Translation: AAK31800.1 .
AK000136 mRNA. Translation: BAA90967.1 . Different initiation.
AK027359 mRNA. Translation: BAB55060.1 .
AY358329 mRNA. Translation: AAQ88695.1 .
AL137848 Genomic DNA. Translation: CAI16697.1 .
CH471089 Genomic DNA. Translation: EAW62822.1 .
RefSeqi NP_001180264.1. NM_001193335.1.
NP_060150.4. NM_017680.4.
UniGenei Hs.435655.

3D structure databases

ProteinModelPortali Q9BXN1.
SMRi Q9BXN1. Positions 74-377.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000364694.

PTM databases

PhosphoSitei Q9BXN1.

Polymorphism databases

DMDMi 209572589.

Proteomic databases

PaxDbi Q9BXN1.
PRIDEi Q9BXN1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000375544 ; ENSP00000364694 ; ENSG00000106819 .
GeneIDi 54829.
KEGGi hsa:54829.
UCSCi uc004ase.2. human.

Organism-specific databases

CTDi 54829.
GeneCardsi GC09M095218.
HGNCi HGNC:14872. ASPN.
HPAi HPA008435.
HPA024230.
MIMi 603932. phenotype.
607850. phenotype.
608135. gene.
neXtProti NX_Q9BXN1.
PharmGKBi PA25057.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG4886.
GeneTreei ENSGT00760000118969.
HOVERGENi HBG016052.
InParanoidi Q9BXN1.
KOi K08120.
OMAi EDFIRYK.
OrthoDBi EOG76739V.
PhylomeDBi Q9BXN1.
TreeFami TF334562.

Enzyme and pathway databases

Reactomei REACT_163906. ECM proteoglycans.

Miscellaneous databases

GeneWikii Asporin.
GenomeRNAii 54829.
NextBioi 57604.
PROi Q9BXN1.
SOURCEi Search...

Gene expression databases

Bgeei Q9BXN1.
CleanExi HS_ASPN.
ExpressionAtlasi Q9BXN1. baseline and differential.
Genevestigatori Q9BXN1.

Family and domain databases

InterProi IPR028548. Asporin.
IPR001611. Leu-rich_rpt.
IPR000372. LRR-contain_N.
IPR016352. SLRP_I_decor/aspor/byglycan.
[Graphical view ]
PANTHERi PTHR24369:SF10. PTHR24369:SF10. 1 hit.
Pfami PF13855. LRR_8. 3 hits.
PF01462. LRRNT. 1 hit.
[Graphical view ]
PIRSFi PIRSF002490. SLRP_I. 1 hit.
SMARTi SM00013. LRRNT. 1 hit.
[Graphical view ]
PROSITEi PS51450. LRR. 7 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification and characterization of asporin. A novel member of the leucine-rich repeat protein family closely related to decorin and biglycan."
    Lorenzo P., Aspberg A., Oennerfjord P., Bayliss M.T., Neame P.J., Heinegaard D.
    J. Biol. Chem. 276:12201-12211(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE, GLYCOSYLATION AT SER-55 AND ASN-282, IDENTIFICATION BY MASS SPECTROMETRY, POLYMORPHISM OF POLY-ASP REGION.
    Tissue: Cartilage.
  2. "Expression profile of active genes in human periodontal ligament and isolation of PLAP-1, a novel SLRP family gene."
    Yamada S., Murakami S., Matoba R., Ozawa Y., Yokokoji T., Nakahira Y., Ikezawa K., Takayama S., Matsubara K., Okada H.
    Gene 275:279-286(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Colon and Embryo.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "Expression pattern and gene characterization of asporin. A newly discovered member of the leucine-rich repeat protein family."
    Henry S.P., Takanosu M., Boyd T.C., Mayne P.M., Eberspaecher H., Zhou W., de Crombrugghe B., Hoeoek M., Mayne R.
    J. Biol. Chem. 276:12212-12221(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: PARTIAL NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Heart.
  8. "An aspartic acid repeat polymorphism in asporin inhibits chondrogenesis and increases susceptibility to osteoarthritis."
    Kizawa H., Kou I., Iida A., Sudo A., Miyamoto Y., Fukuda A., Mabuchi A., Kotani A., Kawakami A., Yamamoto S., Uchida A., Nakamura K., Notoya K., Nakamura Y., Ikegawa S.
    Nat. Genet. 37:138-144(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: ASSOCIATION WITH OS3.
  9. "Mechanisms for asporin function and regulation in articular cartilage."
    Nakajima M., Kizawa H., Saitoh M., Kou I., Miyazono K., Ikegawa S.
    J. Biol. Chem. 282:32185-32192(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, INDUCTION BY TGFB1, TISSUE SPECIFICITY.
  10. Cited for: INVOLVEMENT IN SUSCEPTIBILITY TO IDD.
  11. "Asporin competes with decorin for collagen binding, binds calcium and promotes osteoblast collagen mineralization."
    Kalamajski S., Aspberg A., Lindblom K., Heinegaard D., Oldberg A.
    Biochem. J. 423:53-59(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, IDENTIFICATION BY MASS SPECTROMETRY, INTERACTION WITH TYPE I COLLAGEN, DISULFIDE BOND, DOMAIN.
  12. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
    Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
    J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-282.
    Tissue: Liver.

Entry informationi

Entry nameiASPN_HUMAN
AccessioniPrimary (citable) accession number: Q9BXN1
Secondary accession number(s): Q5TBF3
, Q96K79, Q96LD0, Q9NXP3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2002
Last sequence update: October 14, 2008
Last modified: October 29, 2014
This is version 130 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3