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Q9BXM9

- FSD1L_HUMAN

UniProt

Q9BXM9 - FSD1L_HUMAN

Protein

FSD1-like protein

Gene

FSD1L

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
    • BLAST
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    • History
      Entry version 98 (01 Oct 2014)
      Sequence version 2 (10 Aug 2010)
      Previous versions | rss
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    Names & Taxonomyi

    Protein namesi
    Recommended name:
    FSD1-like protein
    Alternative name(s):
    Coiled-coil domain-containing protein 10
    FSD1 N-terminal-like protein
    Gene namesi
    Name:FSD1L
    Synonyms:CCDC10, CSDUFD1, FSD1CL, FSD1NL
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 9

    Organism-specific databases

    HGNCiHGNC:13753. FSD1L.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA26931.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 530530FSD1-like proteinPRO_0000089405Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei520 – 5201Phosphoserine1 Publication
    Modified residuei523 – 5231Phosphoserine1 Publication

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiQ9BXM9.
    PaxDbiQ9BXM9.
    PRIDEiQ9BXM9.

    PTM databases

    PhosphoSiteiQ9BXM9.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9BXM9.
    BgeeiQ9BXM9.
    CleanExiHS_FSD1L.
    GenevestigatoriQ9BXM9.

    Organism-specific databases

    HPAiHPA035138.

    Interactioni

    Protein-protein interaction databases

    BioGridi123772. 4 interactions.
    IntActiQ9BXM9. 1 interaction.
    STRINGi9606.ENSP00000417492.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9BXM9.
    SMRiQ9BXM9. Positions 83-138, 191-308, 361-498.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini137 – 19458COSPROSITE-ProRule annotationAdd
    BLAST
    Domaini196 – 300105Fibronectin type-IIIPROSITE-ProRule annotationAdd
    BLAST
    Domaini300 – 506207B30.2/SPRYPROSITE-ProRule annotationAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili102 – 14140Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Contains 1 B30.2/SPRY domain.PROSITE-ProRule annotation
    Contains 1 COS domain.PROSITE-ProRule annotation
    Contains 1 fibronectin type-III domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG302398.
    HOGENOMiHOG000231656.
    HOVERGENiHBG107931.
    OMAiQSQLSQC.
    PhylomeDBiQ9BXM9.
    TreeFamiTF333654.

    Family and domain databases

    Gene3Di2.60.40.10. 1 hit.
    InterProiIPR001870. B30.2/SPRY.
    IPR003879. Butyrophylin.
    IPR008985. ConA-like_lec_gl_sf.
    IPR017903. COS_domain.
    IPR003961. Fibronectin_type3.
    IPR013783. Ig-like_fold.
    IPR003877. SPRY_rcpt.
    [Graphical view]
    PfamiPF00041. fn3. 1 hit.
    PF00622. SPRY. 1 hit.
    [Graphical view]
    PRINTSiPR01407. BUTYPHLNCDUF.
    SMARTiSM00060. FN3. 1 hit.
    [Graphical view]
    SUPFAMiSSF49265. SSF49265. 1 hit.
    SSF49899. SSF49899. 1 hit.
    PROSITEiPS50188. B302_SPRY. 1 hit.
    PS51262. COS. 1 hit.
    PS50853. FN3. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9BXM9-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MDSQKYCFKE NENVTVDKAC FLISNITIGP ESINLQQEAL QRIISTLANK    50
    NDEIQNFIDT LHHTLKGVQE NSSNILSELD EEFDSLYSIL DEVKESMINC 100
    IKQEQARKSQ ELQSQISQCN NALENSEELL EFATRSLDIK EPEEFSKAAR 150
    QIKDRVTMAS AFRLSLKPKV SDNMTHLMVD FSQERQMLQT LKFLPVPKAP 200
    EIDPVECLVA DNSVTVAWRM PEEDNKIDHF ILEHRKTNFD GLPRVKDERC 250
    WEIIDNIKGT EYTLSGLKFD SKYMNFRVRA CNKAVAGEYS DPVTLETKAL 300
    NFNLDNSSSH LNLKVEDTCV EWDPTGGKGQ ESKIKGKENK GRSGTPSPKR 350
    TSVGSRPPAV RGSRDRFTGE SYTVLGDTAI ESGQHYWEVK AQKDCKSYSV 400
    GVAYKTLGKF DQLGKTNTSW CIHVNNWLQN TFAAKHNNKV KALDVTVPEK 450
    IGVFCDFDGG QLSFYDANSK QLLYSFKTKF TQPVLPGFMV WCGGLSLSTG 500
    MQVPSAVRTL QKSENGMTGS ASSLNNVVTQ 530

    Note: No experimental confirmation available.

    Length:530
    Mass (Da):59,578
    Last modified:August 10, 2010 - v2
    Checksum:iB2AC94D87F6B6DA1
    GO
    Isoform 2 (identifier: Q9BXM9-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         6-37: Missing.

    Note: No experimental confirmation available. Contains a N-acetylmethionine at position 1.

    Show »
    Length:498
    Mass (Da):55,964
    Checksum:iE534AF3B2960462A
    GO
    Isoform 3 (identifier: Q9BXM9-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         6-37: Missing.
         148-177: AARQIKDRVTMASAFRLSLKPKVSDNMTHL → VHKNCINTLNKGSCIFKKAFLFFFSFGFLY
         178-530: Missing.

    Note: Due to intron retention. Contains a N-acetylmethionine at position 1.

    Show »
    Length:145
    Mass (Da):16,767
    Checksum:iB010A13F7B61FFFA
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti39 – 391A → S in BAH13012. (PubMed:14702039)Curated
    Sequence conflicti342 – 3421Missing in BAH13049. (PubMed:14702039)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei6 – 3732Missing in isoform 2 and isoform 3. 2 PublicationsVSP_039645Add
    BLAST
    Alternative sequencei148 – 17730AARQI…NMTHL → VHKNCINTLNKGSCIFKKAF LFFFSFGFLY in isoform 3. 1 PublicationVSP_039646Add
    BLAST
    Alternative sequencei178 – 530353Missing in isoform 3. 1 PublicationVSP_039647Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF316830 mRNA. Translation: AAK26748.1.
    AK299350 mRNA. Translation: BAH13012.1.
    AK299491 mRNA. Translation: BAH13049.1.
    AL161627 Genomic DNA. Translation: CAI13072.1.
    AL161627, AL158070 Genomic DNA. Translation: CAI13073.2.
    AL158070, AL161627 Genomic DNA. Translation: CAM14451.1.
    CCDSiCCDS47999.1. [Q9BXM9-1]
    CCDS6764.1. [Q9BXM9-3]
    RefSeqiNP_001138785.1. NM_001145313.2. [Q9BXM9-1]
    NP_001274120.1. NM_001287191.1.
    NP_001274121.1. NM_001287192.1.
    NP_114125.1. NM_031919.4. [Q9BXM9-3]
    UniGeneiHs.136901.

    Genome annotation databases

    EnsembliENST00000374710; ENSP00000363842; ENSG00000106701. [Q9BXM9-2]
    ENST00000481272; ENSP00000417492; ENSG00000106701. [Q9BXM9-1]
    ENST00000484973; ENSP00000419691; ENSG00000106701.
    GeneIDi83856.
    KEGGihsa:83856.
    UCSCiuc004bcp.3. human. [Q9BXM9-3]
    uc004bcq.2. human. [Q9BXM9-2]
    uc011lvv.1. human. [Q9BXM9-1]

    Polymorphism databases

    DMDMi302393701.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF316830 mRNA. Translation: AAK26748.1 .
    AK299350 mRNA. Translation: BAH13012.1 .
    AK299491 mRNA. Translation: BAH13049.1 .
    AL161627 Genomic DNA. Translation: CAI13072.1 .
    AL161627 , AL158070 Genomic DNA. Translation: CAI13073.2 .
    AL158070 , AL161627 Genomic DNA. Translation: CAM14451.1 .
    CCDSi CCDS47999.1. [Q9BXM9-1 ]
    CCDS6764.1. [Q9BXM9-3 ]
    RefSeqi NP_001138785.1. NM_001145313.2. [Q9BXM9-1 ]
    NP_001274120.1. NM_001287191.1.
    NP_001274121.1. NM_001287192.1.
    NP_114125.1. NM_031919.4. [Q9BXM9-3 ]
    UniGenei Hs.136901.

    3D structure databases

    ProteinModelPortali Q9BXM9.
    SMRi Q9BXM9. Positions 83-138, 191-308, 361-498.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 123772. 4 interactions.
    IntActi Q9BXM9. 1 interaction.
    STRINGi 9606.ENSP00000417492.

    PTM databases

    PhosphoSitei Q9BXM9.

    Polymorphism databases

    DMDMi 302393701.

    Proteomic databases

    MaxQBi Q9BXM9.
    PaxDbi Q9BXM9.
    PRIDEi Q9BXM9.

    Protocols and materials databases

    DNASUi 83856.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000374710 ; ENSP00000363842 ; ENSG00000106701 . [Q9BXM9-2 ]
    ENST00000481272 ; ENSP00000417492 ; ENSG00000106701 . [Q9BXM9-1 ]
    ENST00000484973 ; ENSP00000419691 ; ENSG00000106701 .
    GeneIDi 83856.
    KEGGi hsa:83856.
    UCSCi uc004bcp.3. human. [Q9BXM9-3 ]
    uc004bcq.2. human. [Q9BXM9-2 ]
    uc011lvv.1. human. [Q9BXM9-1 ]

    Organism-specific databases

    CTDi 83856.
    GeneCardsi GC09P108210.
    HGNCi HGNC:13753. FSD1L.
    HPAi HPA035138.
    MIMi 609829. gene.
    neXtProti NX_Q9BXM9.
    PharmGKBi PA26931.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG302398.
    HOGENOMi HOG000231656.
    HOVERGENi HBG107931.
    OMAi QSQLSQC.
    PhylomeDBi Q9BXM9.
    TreeFami TF333654.

    Miscellaneous databases

    GenomeRNAii 83856.
    NextBioi 35460755.
    PROi Q9BXM9.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9BXM9.
    Bgeei Q9BXM9.
    CleanExi HS_FSD1L.
    Genevestigatori Q9BXM9.

    Family and domain databases

    Gene3Di 2.60.40.10. 1 hit.
    InterProi IPR001870. B30.2/SPRY.
    IPR003879. Butyrophylin.
    IPR008985. ConA-like_lec_gl_sf.
    IPR017903. COS_domain.
    IPR003961. Fibronectin_type3.
    IPR013783. Ig-like_fold.
    IPR003877. SPRY_rcpt.
    [Graphical view ]
    Pfami PF00041. fn3. 1 hit.
    PF00622. SPRY. 1 hit.
    [Graphical view ]
    PRINTSi PR01407. BUTYPHLNCDUF.
    SMARTi SM00060. FN3. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49265. SSF49265. 1 hit.
    SSF49899. SSF49899. 1 hit.
    PROSITEi PS50188. B302_SPRY. 1 hit.
    PS51262. COS. 1 hit.
    PS50853. FN3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Characterization of human FSD1, a novel brain specific gene on chromosome 19 with paralogy to 9q31."
      Carim-Todd L., Escarceller M., Estivill X., Sumoy L.
      Biochim. Biophys. Acta 1518:200-203(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3).
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    3. "DNA sequence and analysis of human chromosome 9."
      Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
      , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
      Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-523, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    5. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-520, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    6. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1 (ISOFORMS 2 AND 3), IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiFSD1L_HUMAN
    AccessioniPrimary (citable) accession number: Q9BXM9
    Secondary accession number(s): A2A338
    , A6NKH7, B7Z5S6, B7Z5W3, Q5T879, Q5T880
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 23, 2004
    Last sequence update: August 10, 2010
    Last modified: October 1, 2014
    This is version 98 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 9
      Human chromosome 9: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3