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Q9BXM9

- FSD1L_HUMAN

UniProt

Q9BXM9 - FSD1L_HUMAN

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Protein

FSD1-like protein

Gene

FSD1L

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
FSD1-like protein
Alternative name(s):
Coiled-coil domain-containing protein 10
FSD1 N-terminal-like protein
Gene namesi
Name:FSD1L
Synonyms:CCDC10, CSDUFD1, FSD1CL, FSD1NL
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 9

Organism-specific databases

HGNCiHGNC:13753. FSD1L.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA26931.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 530530FSD1-like proteinPRO_0000089405Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei520 – 5201Phosphoserine1 Publication
Modified residuei523 – 5231Phosphoserine1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ9BXM9.
PaxDbiQ9BXM9.
PRIDEiQ9BXM9.

PTM databases

PhosphoSiteiQ9BXM9.

Expressioni

Gene expression databases

BgeeiQ9BXM9.
CleanExiHS_FSD1L.
ExpressionAtlasiQ9BXM9. baseline and differential.
GenevestigatoriQ9BXM9.

Organism-specific databases

HPAiHPA035138.

Interactioni

Protein-protein interaction databases

BioGridi123772. 4 interactions.
IntActiQ9BXM9. 1 interaction.
STRINGi9606.ENSP00000417492.

Structurei

3D structure databases

ProteinModelPortaliQ9BXM9.
SMRiQ9BXM9. Positions 191-308, 361-498.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini137 – 19458COSPROSITE-ProRule annotationAdd
BLAST
Domaini196 – 300105Fibronectin type-IIIPROSITE-ProRule annotationAdd
BLAST
Domaini300 – 506207B30.2/SPRYPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili102 – 14140Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Contains 1 B30.2/SPRY domain.PROSITE-ProRule annotation
Contains 1 COS domain.PROSITE-ProRule annotation
Contains 1 fibronectin type-III domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG302398.
GeneTreeiENSGT00760000118878.
HOGENOMiHOG000231656.
HOVERGENiHBG107931.
InParanoidiQ9BXM9.
OMAiQSQLSQC.
PhylomeDBiQ9BXM9.
TreeFamiTF333654.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR001870. B30.2/SPRY.
IPR003879. Butyrophylin.
IPR013320. ConA-like_dom.
IPR017903. COS_domain.
IPR003961. Fibronectin_type3.
IPR013783. Ig-like_fold.
IPR003877. SPRY_dom.
[Graphical view]
PfamiPF00041. fn3. 1 hit.
PF00622. SPRY. 1 hit.
[Graphical view]
PRINTSiPR01407. BUTYPHLNCDUF.
SMARTiSM00060. FN3. 1 hit.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 1 hit.
SSF49899. SSF49899. 1 hit.
PROSITEiPS50188. B302_SPRY. 1 hit.
PS51262. COS. 1 hit.
PS50853. FN3. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9BXM9-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDSQKYCFKE NENVTVDKAC FLISNITIGP ESINLQQEAL QRIISTLANK
60 70 80 90 100
NDEIQNFIDT LHHTLKGVQE NSSNILSELD EEFDSLYSIL DEVKESMINC
110 120 130 140 150
IKQEQARKSQ ELQSQISQCN NALENSEELL EFATRSLDIK EPEEFSKAAR
160 170 180 190 200
QIKDRVTMAS AFRLSLKPKV SDNMTHLMVD FSQERQMLQT LKFLPVPKAP
210 220 230 240 250
EIDPVECLVA DNSVTVAWRM PEEDNKIDHF ILEHRKTNFD GLPRVKDERC
260 270 280 290 300
WEIIDNIKGT EYTLSGLKFD SKYMNFRVRA CNKAVAGEYS DPVTLETKAL
310 320 330 340 350
NFNLDNSSSH LNLKVEDTCV EWDPTGGKGQ ESKIKGKENK GRSGTPSPKR
360 370 380 390 400
TSVGSRPPAV RGSRDRFTGE SYTVLGDTAI ESGQHYWEVK AQKDCKSYSV
410 420 430 440 450
GVAYKTLGKF DQLGKTNTSW CIHVNNWLQN TFAAKHNNKV KALDVTVPEK
460 470 480 490 500
IGVFCDFDGG QLSFYDANSK QLLYSFKTKF TQPVLPGFMV WCGGLSLSTG
510 520 530
MQVPSAVRTL QKSENGMTGS ASSLNNVVTQ

Note: No experimental confirmation available.

Length:530
Mass (Da):59,578
Last modified:August 10, 2010 - v2
Checksum:iB2AC94D87F6B6DA1
GO
Isoform 2 (identifier: Q9BXM9-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     6-37: Missing.

Note: No experimental confirmation available. Contains a N-acetylmethionine at position 1.

Show »
Length:498
Mass (Da):55,964
Checksum:iE534AF3B2960462A
GO
Isoform 3 (identifier: Q9BXM9-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     6-37: Missing.
     148-177: AARQIKDRVTMASAFRLSLKPKVSDNMTHL → VHKNCINTLNKGSCIFKKAFLFFFSFGFLY
     178-530: Missing.

Note: Due to intron retention. Contains a N-acetylmethionine at position 1.

Show »
Length:145
Mass (Da):16,767
Checksum:iB010A13F7B61FFFA
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti39 – 391A → S in BAH13012. (PubMed:14702039)Curated
Sequence conflicti342 – 3421Missing in BAH13049. (PubMed:14702039)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei6 – 3732Missing in isoform 2 and isoform 3. 2 PublicationsVSP_039645Add
BLAST
Alternative sequencei148 – 17730AARQI…NMTHL → VHKNCINTLNKGSCIFKKAF LFFFSFGFLY in isoform 3. 1 PublicationVSP_039646Add
BLAST
Alternative sequencei178 – 530353Missing in isoform 3. 1 PublicationVSP_039647Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF316830 mRNA. Translation: AAK26748.1.
AK299350 mRNA. Translation: BAH13012.1.
AK299491 mRNA. Translation: BAH13049.1.
AL161627 Genomic DNA. Translation: CAI13072.1.
AL161627, AL158070 Genomic DNA. Translation: CAI13073.2.
AL158070, AL161627 Genomic DNA. Translation: CAM14451.1.
CCDSiCCDS47999.1. [Q9BXM9-1]
RefSeqiNP_001138785.1. NM_001145313.2. [Q9BXM9-1]
NP_001274120.1. NM_001287191.1.
NP_001274121.1. NM_001287192.1.
NP_114125.1. NM_031919.4. [Q9BXM9-3]
UniGeneiHs.136901.

Genome annotation databases

EnsembliENST00000481272; ENSP00000417492; ENSG00000106701. [Q9BXM9-1]
ENST00000484973; ENSP00000419691; ENSG00000106701.
GeneIDi83856.
KEGGihsa:83856.
UCSCiuc004bcp.3. human. [Q9BXM9-3]
uc004bcq.2. human. [Q9BXM9-2]
uc011lvv.1. human. [Q9BXM9-1]

Polymorphism databases

DMDMi302393701.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF316830 mRNA. Translation: AAK26748.1 .
AK299350 mRNA. Translation: BAH13012.1 .
AK299491 mRNA. Translation: BAH13049.1 .
AL161627 Genomic DNA. Translation: CAI13072.1 .
AL161627 , AL158070 Genomic DNA. Translation: CAI13073.2 .
AL158070 , AL161627 Genomic DNA. Translation: CAM14451.1 .
CCDSi CCDS47999.1. [Q9BXM9-1 ]
RefSeqi NP_001138785.1. NM_001145313.2. [Q9BXM9-1 ]
NP_001274120.1. NM_001287191.1.
NP_001274121.1. NM_001287192.1.
NP_114125.1. NM_031919.4. [Q9BXM9-3 ]
UniGenei Hs.136901.

3D structure databases

ProteinModelPortali Q9BXM9.
SMRi Q9BXM9. Positions 191-308, 361-498.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 123772. 4 interactions.
IntActi Q9BXM9. 1 interaction.
STRINGi 9606.ENSP00000417492.

PTM databases

PhosphoSitei Q9BXM9.

Polymorphism databases

DMDMi 302393701.

Proteomic databases

MaxQBi Q9BXM9.
PaxDbi Q9BXM9.
PRIDEi Q9BXM9.

Protocols and materials databases

DNASUi 83856.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000481272 ; ENSP00000417492 ; ENSG00000106701 . [Q9BXM9-1 ]
ENST00000484973 ; ENSP00000419691 ; ENSG00000106701 .
GeneIDi 83856.
KEGGi hsa:83856.
UCSCi uc004bcp.3. human. [Q9BXM9-3 ]
uc004bcq.2. human. [Q9BXM9-2 ]
uc011lvv.1. human. [Q9BXM9-1 ]

Organism-specific databases

CTDi 83856.
GeneCardsi GC09P108210.
HGNCi HGNC:13753. FSD1L.
HPAi HPA035138.
MIMi 609829. gene.
neXtProti NX_Q9BXM9.
PharmGKBi PA26931.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG302398.
GeneTreei ENSGT00760000118878.
HOGENOMi HOG000231656.
HOVERGENi HBG107931.
InParanoidi Q9BXM9.
OMAi QSQLSQC.
PhylomeDBi Q9BXM9.
TreeFami TF333654.

Miscellaneous databases

GenomeRNAii 83856.
NextBioi 35460755.
PROi Q9BXM9.
SOURCEi Search...

Gene expression databases

Bgeei Q9BXM9.
CleanExi HS_FSD1L.
ExpressionAtlasi Q9BXM9. baseline and differential.
Genevestigatori Q9BXM9.

Family and domain databases

Gene3Di 2.60.40.10. 1 hit.
InterProi IPR001870. B30.2/SPRY.
IPR003879. Butyrophylin.
IPR013320. ConA-like_dom.
IPR017903. COS_domain.
IPR003961. Fibronectin_type3.
IPR013783. Ig-like_fold.
IPR003877. SPRY_dom.
[Graphical view ]
Pfami PF00041. fn3. 1 hit.
PF00622. SPRY. 1 hit.
[Graphical view ]
PRINTSi PR01407. BUTYPHLNCDUF.
SMARTi SM00060. FN3. 1 hit.
[Graphical view ]
SUPFAMi SSF49265. SSF49265. 1 hit.
SSF49899. SSF49899. 1 hit.
PROSITEi PS50188. B302_SPRY. 1 hit.
PS51262. COS. 1 hit.
PS50853. FN3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of human FSD1, a novel brain specific gene on chromosome 19 with paralogy to 9q31."
    Carim-Todd L., Escarceller M., Estivill X., Sumoy L.
    Biochim. Biophys. Acta 1518:200-203(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3).
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
  3. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-523, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  5. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-520, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  6. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1 (ISOFORMS 2 AND 3), IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiFSD1L_HUMAN
AccessioniPrimary (citable) accession number: Q9BXM9
Secondary accession number(s): A2A338
, A6NKH7, B7Z5S6, B7Z5W3, Q5T879, Q5T880
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: August 10, 2010
Last modified: October 29, 2014
This is version 99 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3