Q9BXM9 (FSD1L_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
FSD1-like protein

Alternative name(s):
Coiled-coil domain-containing protein 10
FSD1 N-terminal-like protein

Gene names

Name:	FSD1L
Synonyms:	CCDC10, CSDUFD1, FSD1CL, FSD1NL

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	530 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Sequence similarities

Contains 1 B30.2/SPRY domain. Contains 1 COS domain. Contains 1 fibronectin type-III domain.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing
Domain	Coiled coil
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9BXM9-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Note: No experimental confirmation available.

Isoform 2 (identifier: Q9BXM9-2)

The sequence of this isoform differs from the canonical sequence as follows:
     6-37: Missing.

Note: No experimental confirmation available.

Isoform 3 (identifier: Q9BXM9-3)

The sequence of this isoform differs from the canonical sequence as follows:
     6-37: Missing.
     148-177: AARQIKDRVTMASAFRLSLKPKVSDNMTHL → VHKNCINTLNKGSCIFKKAFLFFFSFGFLY
     178-530: Missing.

Note: Due to intron retention.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 530	530	FSD1-like protein		PRO_0000089405
Regions
	Domain	137 – 194	58	COS
	Domain	195 – 299	105	Fibronectin type-III
	Domain	300 – 506	207	B30.2/SPRY
	Coiled coil	102 – 141	40	Potential
Amino acid modifications
	Modified residue	520	1	Phosphoserine Ref.5
	Modified residue	523	1	Phosphoserine Ref.4
Natural variations
	Alternative sequence	6 – 37	32	Missing in isoform 2 and isoform 3.		VSP_039645
	Alternative sequence	148 – 177	30	AARQI…NMTHL → VHKNCINTLNKGSCIFKKAF LFFFSFGFLY in isoform 3.		VSP_039646
	Alternative sequence	178 – 530	353	Missing in isoform 3.		VSP_039647
Experimental info
	Sequence conflict	39	1	A → S in BAH13012. Ref.2
	Sequence conflict	342	1	Missing in BAH13049. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified August 10, 2010. Version 2. Checksum: B2AC94D87F6B6DA1	FASTA	530	59,578
	10 20 30 40 50 60 MDSQKYCFKE NENVTVDKAC FLISNITIGP ESINLQQEAL QRIISTLANK NDEIQNFIDT 70 80 90 100 110 120 LHHTLKGVQE NSSNILSELD EEFDSLYSIL DEVKESMINC IKQEQARKSQ ELQSQISQCN 130 140 150 160 170 180 NALENSEELL EFATRSLDIK EPEEFSKAAR QIKDRVTMAS AFRLSLKPKV SDNMTHLMVD 190 200 210 220 230 240 FSQERQMLQT LKFLPVPKAP EIDPVECLVA DNSVTVAWRM PEEDNKIDHF ILEHRKTNFD 250 260 270 280 290 300 GLPRVKDERC WEIIDNIKGT EYTLSGLKFD SKYMNFRVRA CNKAVAGEYS DPVTLETKAL 310 320 330 340 350 360 NFNLDNSSSH LNLKVEDTCV EWDPTGGKGQ ESKIKGKENK GRSGTPSPKR TSVGSRPPAV 370 380 390 400 410 420 RGSRDRFTGE SYTVLGDTAI ESGQHYWEVK AQKDCKSYSV GVAYKTLGKF DQLGKTNTSW 430 440 450 460 470 480 CIHVNNWLQN TFAAKHNNKV KALDVTVPEK IGVFCDFDGG QLSFYDANSK QLLYSFKTKF 490 500 510 520 530 TQPVLPGFMV WCGGLSLSTG MQVPSAVRTL QKSENGMTGS ASSLNNVVTQ
	Isoform 2 [UniParc]. Checksum: E534AF3B2960462A	FASTA	498	55,964
	10 20 30 40 50 60 MDSQKEALQR IISTLANKND EIQNFIDTLH HTLKGVQENS SNILSELDEE FDSLYSILDE 70 80 90 100 110 120 VKESMINCIK QEQARKSQEL QSQISQCNNA LENSEELLEF ATRSLDIKEP EEFSKAARQI 130 140 150 160 170 180 KDRVTMASAF RLSLKPKVSD NMTHLMVDFS QERQMLQTLK FLPVPKAPEI DPVECLVADN 190 200 210 220 230 240 SVTVAWRMPE EDNKIDHFIL EHRKTNFDGL PRVKDERCWE IIDNIKGTEY TLSGLKFDSK 250 260 270 280 290 300 YMNFRVRACN KAVAGEYSDP VTLETKALNF NLDNSSSHLN LKVEDTCVEW DPTGGKGQES 310 320 330 340 350 360 KIKGKENKGR SGTPSPKRTS VGSRPPAVRG SRDRFTGESY TVLGDTAIES GQHYWEVKAQ 370 380 390 400 410 420 KDCKSYSVGV AYKTLGKFDQ LGKTNTSWCI HVNNWLQNTF AAKHNNKVKA LDVTVPEKIG 430 440 450 460 470 480 VFCDFDGGQL SFYDANSKQL LYSFKTKFTQ PVLPGFMVWC GGLSLSTGMQ VPSAVRTLQK 490 SENGMTGSAS SLNNVVTQ
	Isoform 3 [UniParc]. Checksum: B010A13F7B61FFFA	FASTA	145	16,767
	10 20 30 40 50 60 MDSQKEALQR IISTLANKND EIQNFIDTLH HTLKGVQENS SNILSELDEE FDSLYSILDE 70 80 90 100 110 120 VKESMINCIK QEQARKSQEL QSQISQCNNA LENSEELLEF ATRSLDIKEP EEFSKVHKNC 130 140 INTLNKGSCI FKKAFLFFFS FGFLY

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Characterization of human FSD1, a novel brain specific gene on chromosome 19 with paralogy to 9q31." Carim-Todd L., Escarceller M., Estivill X., Sumoy L. Biochim. Biophys. Acta 1518:200-203(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3).
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
[3]	"DNA sequence and analysis of human chromosome 9." Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L. , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I. Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-523, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[5]	"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis." Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M. Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-520, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF316830 mRNA. Translation: AAK26748.1. AK299350 mRNA. Translation: BAH13012.1. AK299491 mRNA. Translation: BAH13049.1. AL161627 Genomic DNA. Translation: CAI13072.1. AL161627, AL158070 Genomic DNA. Translation: CAI13073.2. AL158070, AL161627 Genomic DNA. Translation: CAM14451.1.
IPI	IPI00011117. IPI00513845. IPI00921807.
RefSeq	NP_001138785.1. NM_001145313.1. NP_114125.1. NM_031919.3. NP_997530.2. NM_207647.2.
UniGene	Hs.136901.
3D structure databases
ProteinModelPortal	Q9BXM9.
SMR	Q9BXM9. Positions 191-308, 374-488.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9BXM9. 1 interaction.
STRING	9606.ENSP00000417492.
PTM databases
PhosphoSite	Q9BXM9.
Polymorphism databases
DMDM	302393701.
Proteomic databases
PaxDb	Q9BXM9.
PRIDE	Q9BXM9.
Protocols and materials databases
DNASU	83856.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000374710; ENSP00000363842; ENSG00000106701. ENST00000374716; ENSP00000363848; ENSG00000106701. ENST00000481272; ENSP00000417492; ENSG00000106701. ENST00000484973; ENSP00000419691; ENSG00000106701.
GeneID	83856.
KEGG	hsa:83856.
UCSC	uc004bcp.3. human. uc004bcq.2. human. uc011lvv.1. human.
Organism-specific databases
CTD	83856.
GeneCards	GC09P108210.
HGNC	HGNC:13753. FSD1L.
HPA	HPA035138.
MIM	609829. gene.
neXtProt	NX_Q9BXM9.
PharmGKB	PA26931.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG302398.
HOGENOM	HOG000231656.
HOVERGEN	HBG107931.
OMA	QSQLSQC.
Gene expression databases
ArrayExpress	Q9BXM9.
Bgee	Q9BXM9.
CleanEx	HS_FSD1L.
Genevestigator	Q9BXM9.
GermOnline	ENSG00000106701. Homo sapiens.
Family and domain databases
Gene3D	2.60.40.10. 1 hit.
InterPro	IPR001870. B30.2/SPRY. IPR003879. Butyrophylin. IPR008985. ConA-like_lec_gl_sf. IPR017903. COS_domain. IPR003961. Fibronectin_type3. IPR013783. Ig-like_fold. IPR003877. SPRY_rcpt. [Graphical view]
Pfam	PF00041. fn3. 1 hit. PF00622. SPRY. 1 hit. [Graphical view]
PRINTS	PR01407. BUTYPHLNCDUF.
SMART	SM00060. FN3. 1 hit. [Graphical view]
SUPFAM	SSF49899. ConA_like_lec_gl. 1 hit. SSF49265. FN_III-like. 1 hit.
PROSITE	PS50188. B302_SPRY. 1 hit. PS51262. COS. 1 hit. PS50853. FN3. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	83856.
NextBio	35460755.
SOURCE	Search...

Entry information

Entry name

FSD1L_HUMAN

Accession

Primary (citable) accession number: Q9BXM9
Secondary accession number(s): A2A338 , A6NKH7, B7Z5S6, B7Z5W3, Q5T879, Q5T880

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 23, 2004
Last sequence update:	August 10, 2010
Last modified:	May 1, 2013
This is version 84 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.