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Protein

Periaxin

Gene

PRX

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Scaffolding protein that functions as part of a dystroglycan complex in Schwann cells, and as part of EZR and AHNAK-containing complexes in eye lens fiber cells. Required for the maintenance of the peripheral myelin sheath that is essential for normal transmission of nerve impulses and normal perception of sensory stimuli. Required for normal transport of MBP mRNA from the perinuclear to the paranodal regions. Required for normal remyelination after nerve injury. Required for normal elongation of Schwann cells and normal length of the internodes between the nodes of Ranvier. The demyelinated nodes of Ranvier permit saltatory transmission of nerve impulses; shorter internodes cause slower transmission of nerve impulses. Required for the formation of appositions between the abaxonal surface of the myelin sheath and the Schwann cell plasma membrane; the Schwann cell cytoplasm is restricted to regions between these appositions. Required for the formation of Cajal bands and of Schmidt-Lanterman incisures that correspond to short, cytoplasm-filled regions on myelinated nerves. Recruits DRP2 to the Schwann cell plasma membrane. Required for normal protein composition of the eye lens fiber cell plasma membrane and normal eye lens fiber cell morphology.By similarity

GO - Biological processi

  • axon ensheathment Source: UniProtKB
Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000105227-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Periaxin
Gene namesi
Name:PRX
Synonyms:KIAA1620
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:13797. PRX.

Subcellular locationi

Isoform 1 :
  • Cell membrane By similarity; Peripheral membrane protein By similarity; Cytoplasmic side By similarity
  • Nucleus 1 Publication
  • Cytoplasm 1 Publication

  • Note: Detected in the Schwann cell nucleus prior to the onset of myelination. Detected in Schwann cells at periaxonal myelin membranes. Associated with the cell membrane during myelination.By similarity
Isoform 2 :
  • Cytoplasm By similarity
  • Cell membrane By similarity
  • Cell junction By similarity

  • Note: Colocalizes with ACTB at tricellular junctions between eye lens fiber cells.By similarity

GO - Cellular componenti

  • cell junction Source: UniProtKB-SubCell
  • cytoplasm Source: UniProtKB
  • nucleus Source: UniProtKB
  • plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Cytoplasm, Membrane, Nucleus

Pathology & Biotechi

Involvement in diseasei

Dejerine-Sottas syndrome (DSS)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA severe degenerating neuropathy of the demyelinating Charcot-Marie-Tooth disease category, with onset by age 2 years. Characterized by motor and sensory neuropathy with very slow nerve conduction velocities, increased cerebrospinal fluid protein concentrations, hypertrophic nerve changes, delayed age of walking as well as areflexia. There are both autosomal dominant and autosomal recessive forms of Dejerine-Sottas syndrome.
See also OMIM:145900
Charcot-Marie-Tooth disease 4F (CMT4F)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA recessive demyelinating form of Charcot-Marie-Tooth disease, a disorder of the peripheral nervous system, characterized by progressive weakness and atrophy, initially of the peroneal muscles and later of the distal muscles of the arms. Charcot-Marie-Tooth disease is classified in two main groups on the basis of electrophysiologic properties and histopathology: primary peripheral demyelinating neuropathies (designated CMT1 when they are dominantly inherited) and primary peripheral axonal neuropathies (CMT2). Demyelinating neuropathies are characterized by severely reduced nerve conduction velocities (less than 38 m/sec), segmental demyelination and remyelination with onion bulb formations on nerve biopsy, slowly progressive distal muscle atrophy and weakness, absent deep tendon reflexes, and hollow feet. By convention autosomal recessive forms of demyelinating Charcot-Marie-Tooth disease are designated CMT4. CMT4F is characterized by distal sensory impairment and distal muscle weakness and atrophy affecting the lower more than the upper limbs. The age at onset is variable and can range from childhood to adult years. When the onset is in infancy, the phenotype is characterized as Dejerine-Sottas syndrome.
See also OMIM:614895
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_069093651D → N in CMT4F. 1 PublicationCorresponds to variant rs3814290dbSNPEnsembl.1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi81 – 83LRL → QRQ: Nearly abolishes export from the nucleus. 1 Publication3

Keywords - Diseasei

Charcot-Marie-Tooth disease, Dejerine-Sottas syndrome, Disease mutation, Neurodegeneration, Neuropathy

Organism-specific databases

DisGeNETi57716.
MalaCardsiPRX.
MIMi145900. phenotype.
614895. phenotype.
OpenTargetsiENSG00000105227.
Orphaneti99952. Charcot-Marie-Tooth disease type 4F.
64748. Dejerine-Sottas syndrome.
PharmGKBiPA33843.

Polymorphism and mutation databases

BioMutaiPRX.
DMDMi317373270.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000585631 – 1461PeriaxinAdd BLAST1461

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei7PhosphoserineBy similarity1
Modified residuei133PhosphoserineBy similarity1
Modified residuei900PhosphoserineBy similarity1
Modified residuei1082PhosphoserineBy similarity1
Modified residuei1349PhosphoserineBy similarity1
Modified residuei1351PhosphoserineBy similarity1
Modified residuei1363PhosphoserineBy similarity1
Modified residuei1401PhosphoserineBy similarity1
Modified residuei1407PhosphoserineBy similarity1
Modified residuei1439PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9BXM0.
PeptideAtlasiQ9BXM0.
PRIDEiQ9BXM0.

PTM databases

iPTMnetiQ9BXM0.
PhosphoSitePlusiQ9BXM0.

Expressioni

Tissue specificityi

Detected in spinal cord (PubMed:11133365). Isoform 1 and isoform 2 are found in sciatic nerve and Schwann cells (PubMed:11157804).2 Publications

Gene expression databases

BgeeiENSG00000105227.
CleanExiHS_PRX.
GenevisibleiQ9BXM0. HS.

Organism-specific databases

HPAiHPA001868.

Interactioni

Subunit structurei

Homodimer (via PDZ domain) (PubMed:24675079). Interacts with SCN10A. Found in a complex with SCN10A (By similarity). Interacts with DRP2. Identified in a dystroglycan complex that contains at least PRX, DRP2, UTRN, DMD and DAG1 (By similarity). Detected in a complex composed of at least EZR, AHNAK, PPL and PRX (By similarity). Identified in a complex with EZR, AHNAK, BFSP1, BFSP2, ANK2, PLEC, VIM and spectrin (By similarity).By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
NCK1P163332EBI-1753064,EBI-389883
TERF2IPQ9NYB02EBI-1753064,EBI-750109

Protein-protein interaction databases

BioGridi121739. 6 interactors.
IntActiQ9BXM0. 6 interactors.
STRINGi9606.ENSP00000326018.

Structurei

Secondary structure

11461
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi18 – 22Combined sources5
Beta strandi26 – 28Combined sources3
Beta strandi32 – 38Combined sources7
Beta strandi41 – 47Combined sources7
Helixi52 – 56Combined sources5
Beta strandi64 – 71Combined sources8
Helixi77 – 87Combined sources11
Beta strandi90 – 99Combined sources10

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4CMZX-ray2.70A/B/C14-104[»]
ProteinModelPortaliQ9BXM0.
SMRiQ9BXM0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini16 – 99PDZPROSITE-ProRule annotationAdd BLAST84
Repeati431 – 43515
Repeati439 – 44325
Repeati447 – 45135
Repeati455 – 45945
Repeati463 – 46755
Repeati468 – 47265
Repeati473 – 47775
Repeati481 – 48585
Repeati486 – 49095
Repeati494 – 498105
Repeati499 – 503115
Repeati507 – 511125
Repeati512 – 516135
Repeati520 – 524145
Repeati525 – 529155
Repeati533 – 537165
Repeati538 – 542175
Repeati546 – 550185
Repeati551 – 555195
Repeati559 – 563205
Repeati564 – 568215
Repeati572 – 576225
Repeati577 – 581235
Repeati582 – 586245
Repeati590 – 594255
Repeati595 – 599265
Repeati600 – 604275
Repeati608 – 612285
Repeati613 – 617295
Repeati618 – 622305
Repeati626 – 630315
Repeati631 – 635325
Repeati636 – 640335
Repeati644 – 648345
Repeati649 – 653355
Repeati654 – 658365
Repeati662 – 666375
Repeati670 – 674385
Repeati675 – 679395
Repeati683 – 687405
Repeati688 – 692415
Repeati696 – 700425
Repeati701 – 705435
Repeati706 – 710445
Repeati714 – 718455
Repeati719 – 723465
Repeati724 – 728475
Repeati732 – 736485
Repeati737 – 741495
Repeati742 – 746505
Repeati750 – 754515
Repeati755 – 759525
Repeati760 – 764535
Repeati771 – 775545
Repeati779 – 783555

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni431 – 78355 X 5 AA approximate tandem repeats of [LVMAG]-[PSREQC]-[EDKL]-[LIVMAP]-[AQKHRPE]; that may have a tripeptide spacer of [LV]-P-[KER]Add BLAST353

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi70 – 84Nuclear export signal1 PublicationAdd BLAST15
Motifi118 – 196Nuclear localization signalBy similarityAdd BLAST79

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi118 – 196Arg/Lys-rich (basic)Add BLAST79
Compositional biasi1098 – 1235Glu-rich (acidic)Add BLAST138
Compositional biasi1353 – 1361Poly-Glu9

Domaini

Has a remarkable domain of repetitive pentameric units sometimes followed by a tripeptide spacer, it may separate two functional basic and acidic domains.Curated
The Arg/Lys-rich basic domain functions as a tripartite nuclear localization signal.By similarity
The PDZ domain contains the signal for export from the nucleus (PubMed:24633211). The N-terminal region including the PDZ domain is required for the formation of Cajal bands on myelinated nerves.By similarity1 Publication

Sequence similaritiesi

Belongs to the periaxin family.Curated
Contains 1 PDZ (DHR) domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410II3A. Eukaryota.
ENOG410ZMDY. LUCA.
GeneTreeiENSGT00530000063716.
HOGENOMiHOG000168246.
HOVERGENiHBG031836.
InParanoidiQ9BXM0.
OMAiEARVKGP.
OrthoDBiEOG091G0QRS.
PhylomeDBiQ9BXM0.
TreeFamiTF350595.

Family and domain databases

Gene3Di2.30.42.10. 1 hit.
InterProiIPR001478. PDZ.
[Graphical view]
SMARTiSM00228. PDZ. 1 hit.
[Graphical view]
SUPFAMiSSF50156. SSF50156. 1 hit.
PROSITEiPS50106. PDZ. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9BXM0-1) [UniParc]FASTAAdd to basket
Also known as: L-periaxin

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEARSRSAEE LRRAELVEII VETEAQTGVS GINVAGGGKE GIFVRELRED
60 70 80 90 100
SPAARSLSLQ EGDQLLSARV FFENFKYEDA LRLLQCAEPY KVSFCLKRTV
110 120 130 140 150
PTGDLALRPG TVSGYEIKGP RAKVAKLNIQ SLSPVKKKKM VPGALGVPAD
160 170 180 190 200
LAPVDVEFSF PKFSRLRRGL KAEAVKGPVP AAPARRRLQL PRLRVREVAE
210 220 230 240 250
EAQAARLAAA APPPRKAKVE AEVAAGARFT APQVELVGPR LPGAEVGVPQ
260 270 280 290 300
VSAPKAAPSA EAAGGFALHL PTLGLGAPAP PAVEAPAVGI QVPQVELPAL
310 320 330 340 350
PSLPTLPTLP CLETREGAVS VVVPTLDVAA PTVGVDLALP GAEVEARGEA
360 370 380 390 400
PEVALKMPRL SFPRFGARAK EVAEAKVAKV SPEARVKGPR LRMPTFGLSL
410 420 430 440 450
LEPRPAAPEV VESKLKLPTI KMPSLGIGVS GPEVKVPKGP EVKLPKAPEV
460 470 480 490 500
KLPKVPEAAL PEVRLPEVEL PKVSEMKLPK VPEMAVPEVR LPEVELPKVS
510 520 530 540 550
EMKLPKVPEM AVPEVRLPEV QLLKVSEMKL PKVPEMAVPE VRLPEVQLPK
560 570 580 590 600
VSEMKLPEVS EVAVPEVRLP EVQLPKVPEM KVPEMKLPKV PEMKLPEMKL
610 620 630 640 650
PEVQLPKVPE MAVPDVHLPE VQLPKVPEMK LPEMKLPEVK LPKVPEMAVP
660 670 680 690 700
DVHLPEVQLP KVPEMKLPKM PEMAVPEVRL PEVQLPKVSE MKLPKVPEMA
710 720 730 740 750
VPDVHLPEVQ LPKVCEMKVP DMKLPEIKLP KVPEMAVPDV HLPEVQLPKV
760 770 780 790 800
SEIRLPEMQV PKVPDVHLPK APEVKLPRAP EVQLKATKAE QAEGMEFGFK
810 820 830 840 850
MPKMTMPKLG RAESPSRGKP GEAGAEVSGK LVTLPCLQPE VDGEAHVGVP
860 870 880 890 900
SLTLPSVELD LPGALGLQGQ VPAAKMGKGE RVEGPEVAAG VREVGFRVPS
910 920 930 940 950
VEIVTPQLPA VEIEEGRLEM IETKVKPSSK FSLPKFGLSG PKVAKAEAEG
960 970 980 990 1000
AGRATKLKVS KFAISLPKAR VGAEAEAKGA GEAGLLPALD LSIPQLSLDA
1010 1020 1030 1040 1050
HLPSGKVEVA GADLKFKGPR FALPKFGVRG RDTEAAELVP GVAELEGKGW
1060 1070 1080 1090 1100
GWDGRVKMPK LKMPSFGLAR GKEAEVQGDR ASPGEKAEST AVQLKIPEVE
1110 1120 1130 1140 1150
LVTLGAQEEG RAEGAVAVSG MQLSGLKVST AGQVVTEGHD AGLRMPPLGI
1160 1170 1180 1190 1200
SLPQVELTGF GEAGTPGQQA QSTVPSAEGT AGYRVQVPQV TLSLPGAQVA
1210 1220 1230 1240 1250
GGELLVGEGV FKMPTVTVPQ LELDVGLSRE AQAGEAATGE GGLRLKLPTL
1260 1270 1280 1290 1300
GARARVGGEG AEEQPPGAER TFCLSLPDVE LSPSGGNHAE YQVAEGEGEA
1310 1320 1330 1340 1350
GHKLKVRLPR FGLVRAKEGA EEGEKAKSPK LRLPRVGFSQ SEMVTGEGSP
1360 1370 1380 1390 1400
SPEEEEEEEE EGSGEGASGR RGRVRVRLPR VGLAAPSKAS RGQEGDAAPK
1410 1420 1430 1440 1450
SPVREKSPKF RFPRVSLSPK ARSGSGDQEE GGLRVRLPSV GFSETGAPGP
1460
ARMEGAQAAA V
Length:1,461
Mass (Da):154,905
Last modified:January 11, 2011 - v2
Checksum:i41F00C50B1DC3C7A
GO
Isoform 2 (identifier: Q9BXM0-2) [UniParc]FASTAAdd to basket
Also known as: S-periaxin

The sequence of this isoform differs from the canonical sequence as follows:
     128-147: NIQSLSPVKKKKMVPGALGV → VRVLSPAPALDCPSDPVSAP
     148-1461: Missing.

Show »
Length:147
Mass (Da):15,931
Checksum:iED181EF6C33F9128
GO
Isoform 3 (identifier: Q9BXM0-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-139: Missing.

Show »
Length:1,322
Mass (Da):139,613
Checksum:i297EF1FBDE6B031F
GO

Sequence cautioni

The sequence BAB13446 differs from that shown. Aberrant splicing.Curated
The sequence BAB13446 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_013056406A → T.1 PublicationCorresponds to variant rs117336941dbSNPEnsembl.1
Natural variantiVAR_013057495E → Q.1 PublicationCorresponds to variant rs146789340dbSNPEnsembl.1
Natural variantiVAR_073295525V → A Rare polymorphism. 1 PublicationCorresponds to variant rs149715830dbSNPEnsembl.1
Natural variantiVAR_069093651D → N in CMT4F. 1 PublicationCorresponds to variant rs3814290dbSNPEnsembl.1
Natural variantiVAR_013058882V → A.2 PublicationsCorresponds to variant rs268671dbSNPEnsembl.1
Natural variantiVAR_013059921I → M.1 PublicationCorresponds to variant rs268673dbSNPEnsembl.1
Natural variantiVAR_013060935K → E.1 Publication1
Natural variantiVAR_0130611083P → R.1 PublicationCorresponds to variant rs3745202dbSNPEnsembl.1
Natural variantiVAR_0130621132G → R.2 PublicationsCorresponds to variant rs268674dbSNPEnsembl.1
Natural variantiVAR_0130631259E → K.1 PublicationCorresponds to variant rs751742049dbSNPEnsembl.1
Natural variantiVAR_0732961335R → Q Found in a patient with a complex hereditary motor and sensory neuropathy form associated with dysarthria, joints hypermobility and cerebellar signs; unknown pathological significance. 1 Publication1
Natural variantiVAR_0130641359Missing .1 Publication1
Natural variantiVAR_0130651411R → C.1 PublicationCorresponds to variant rs533966999dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0403521 – 139Missing in isoform 3. 1 PublicationAdd BLAST139
Alternative sequenceiVSP_004363128 – 147NIQSL…GALGV → VRVLSPAPALDCPSDPVSAP in isoform 2. 1 PublicationAdd BLAST20
Alternative sequenceiVSP_004364148 – 1461Missing in isoform 2. 1 PublicationAdd BLAST1314

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF321191 mRNA. Translation: AAK19279.1.
AF321192 mRNA. Translation: AAK19280.1.
AB046840 mRNA. Translation: BAB13446.1. Sequence problems.
AC010271 Genomic DNA. No translation available.
BC067266 mRNA. Translation: AAH67266.1.
CCDSiCCDS12556.1. [Q9BXM0-2]
CCDS33028.1. [Q9BXM0-1]
RefSeqiNP_066007.1. NM_020956.2. [Q9BXM0-2]
NP_870998.2. NM_181882.2. [Q9BXM0-1]
XP_011525473.1. XM_011527171.2. [Q9BXM0-1]
UniGeneiHs.205457.

Genome annotation databases

EnsembliENST00000291825; ENSP00000291825; ENSG00000105227. [Q9BXM0-2]
ENST00000324001; ENSP00000326018; ENSG00000105227. [Q9BXM0-1]
GeneIDi57716.
KEGGihsa:57716.
UCSCiuc002onr.4. human. [Q9BXM0-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Inherited peripheral neuropathies mutation db

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF321191 mRNA. Translation: AAK19279.1.
AF321192 mRNA. Translation: AAK19280.1.
AB046840 mRNA. Translation: BAB13446.1. Sequence problems.
AC010271 Genomic DNA. No translation available.
BC067266 mRNA. Translation: AAH67266.1.
CCDSiCCDS12556.1. [Q9BXM0-2]
CCDS33028.1. [Q9BXM0-1]
RefSeqiNP_066007.1. NM_020956.2. [Q9BXM0-2]
NP_870998.2. NM_181882.2. [Q9BXM0-1]
XP_011525473.1. XM_011527171.2. [Q9BXM0-1]
UniGeneiHs.205457.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4CMZX-ray2.70A/B/C14-104[»]
ProteinModelPortaliQ9BXM0.
SMRiQ9BXM0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121739. 6 interactors.
IntActiQ9BXM0. 6 interactors.
STRINGi9606.ENSP00000326018.

PTM databases

iPTMnetiQ9BXM0.
PhosphoSitePlusiQ9BXM0.

Polymorphism and mutation databases

BioMutaiPRX.
DMDMi317373270.

Proteomic databases

PaxDbiQ9BXM0.
PeptideAtlasiQ9BXM0.
PRIDEiQ9BXM0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000291825; ENSP00000291825; ENSG00000105227. [Q9BXM0-2]
ENST00000324001; ENSP00000326018; ENSG00000105227. [Q9BXM0-1]
GeneIDi57716.
KEGGihsa:57716.
UCSCiuc002onr.4. human. [Q9BXM0-1]

Organism-specific databases

CTDi57716.
DisGeNETi57716.
GeneCardsiPRX.
GeneReviewsiPRX.
H-InvDBHIX0015135.
HGNCiHGNC:13797. PRX.
HPAiHPA001868.
MalaCardsiPRX.
MIMi145900. phenotype.
605725. gene.
614895. phenotype.
neXtProtiNX_Q9BXM0.
OpenTargetsiENSG00000105227.
Orphaneti99952. Charcot-Marie-Tooth disease type 4F.
64748. Dejerine-Sottas syndrome.
PharmGKBiPA33843.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410II3A. Eukaryota.
ENOG410ZMDY. LUCA.
GeneTreeiENSGT00530000063716.
HOGENOMiHOG000168246.
HOVERGENiHBG031836.
InParanoidiQ9BXM0.
OMAiEARVKGP.
OrthoDBiEOG091G0QRS.
PhylomeDBiQ9BXM0.
TreeFamiTF350595.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000105227-MONOMER.

Miscellaneous databases

GeneWikiiPRX_(gene).
GenomeRNAii57716.
PROiQ9BXM0.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000105227.
CleanExiHS_PRX.
GenevisibleiQ9BXM0. HS.

Family and domain databases

Gene3Di2.30.42.10. 1 hit.
InterProiIPR001478. PDZ.
[Graphical view]
SMARTiSM00228. PDZ. 1 hit.
[Graphical view]
SUPFAMiSSF50156. SSF50156. 1 hit.
PROSITEiPS50106. PDZ. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPRAX_HUMAN
AccessioniPrimary (citable) accession number: Q9BXM0
Secondary accession number(s): Q9BXL9, Q9HCF2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 16, 2002
Last sequence update: January 11, 2011
Last modified: November 2, 2016
This is version 153 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.