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Q9BXL8

- CDCA4_HUMAN

UniProt

Q9BXL8 - CDCA4_HUMAN

Protein

Cell division cycle-associated protein 4

Gene

CDCA4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 91 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
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    Functioni

    May participate in the regulation of cell proliferation through the E2F/RB pathway. May be involved in molecular regulation of hematopoietic stem cells and progenitor cell lineage commitment and differentiation By similarity.By similarity

    GO - Molecular functioni

    1. protein binding Source: IntAct

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cell division cycle-associated protein 4
    Alternative name(s):
    Hematopoietic progenitor protein
    Gene namesi
    Name:CDCA4
    Synonyms:HEPP
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 14

    Organism-specific databases

    HGNCiHGNC:14625. CDCA4.

    Subcellular locationi

    Nucleus 1 Publication

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA26277.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 241241Cell division cycle-associated protein 4PRO_0000191617Add
    BLAST

    Proteomic databases

    MaxQBiQ9BXL8.
    PaxDbiQ9BXL8.
    PRIDEiQ9BXL8.

    PTM databases

    PhosphoSiteiQ9BXL8.

    Expressioni

    Tissue specificityi

    Highest levels of expression in the pancreas, thymus, testis, spleen, liver, placenta and leukocytes. Relatively low levels in the lung, kidney, prostate, ovary, small intestine and colon. Hardly detectable, if at all, in the brain, skeletal muscle and heart.1 Publication

    Inductioni

    By E2F1.1 Publication

    Gene expression databases

    BgeeiQ9BXL8.
    CleanExiHS_CDCA4.
    GenevestigatoriQ9BXL8.

    Organism-specific databases

    HPAiHPA059416.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    KDM1AO603412EBI-1773949,EBI-710124
    PRMT6Q96LA82EBI-1773949,EBI-912440
    SUV39H1O434632EBI-1773949,EBI-349968
    SUV39H2Q9H5I12EBI-1773949,EBI-723127

    Protein-protein interaction databases

    BioGridi120367. 13 interactions.
    IntActiQ9BXL8. 9 interactions.
    MINTiMINT-8417649.
    STRINGi9606.ENSP00000337226.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9BXL8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini30 – 7748SERTAPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 SERTA domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG42395.
    HOGENOMiHOG000111497.
    HOVERGENiHBG050861.
    InParanoidiQ9BXL8.
    OMAiTQDGTWQ.
    OrthoDBiEOG7PCJHX.
    PhylomeDBiQ9BXL8.
    TreeFamiTF101069.

    Family and domain databases

    InterProiIPR009263. SERTA_dom.
    [Graphical view]
    PfamiPF06031. SERTA. 1 hit.
    [Graphical view]
    PROSITEiPS51053. SERTA. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9BXL8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MFARGLKRKC VGHEEDVEGA LAGLKTVSSY SLQRQSLLDM SLVKLQLCHM    50
    LVEPNLCRSV LIANTVRQIQ EEMTQDGTWR TVAPQAAERA PLDRLVSTEI 100
    LCRAAWGQEG AHPAPGLGDG HTQGPVSDLC PVTSAQAPRH LQSSAWEMDG 150
    PRENRGSFHK SLDQIFETLE TKNPSCMEEL FSDVDSPYYD LDTVLTGMMG 200
    GARPGPCEGL EGLAPATPGP SSSCKSDLGE LDHVVEILVE T 241
    Length:241
    Mass (Da):26,114
    Last modified:June 1, 2001 - v1
    Checksum:i9693647E77865D7A
    GO

    Sequence cautioni

    The sequence BAA91373.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti93 – 931D → N in AAH25263. (PubMed:15489334)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF322239 mRNA. Translation: AAK31075.1.
    BC011736 mRNA. Translation: AAH11736.1.
    BC025263 mRNA. Translation: AAH25263.1.
    AK000771 mRNA. Translation: BAA91373.1. Different initiation.
    CCDSiCCDS9996.1.
    RefSeqiNP_060425.2. NM_017955.3.
    NP_663747.1. NM_145701.2.
    UniGeneiHs.34045.

    Genome annotation databases

    EnsembliENST00000336219; ENSP00000337226; ENSG00000170779.
    ENST00000392590; ENSP00000376369; ENSG00000170779.
    GeneIDi55038.
    KEGGihsa:55038.
    UCSCiuc001yqa.2. human.

    Polymorphism databases

    DMDMi32699606.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF322239 mRNA. Translation: AAK31075.1 .
    BC011736 mRNA. Translation: AAH11736.1 .
    BC025263 mRNA. Translation: AAH25263.1 .
    AK000771 mRNA. Translation: BAA91373.1 . Different initiation.
    CCDSi CCDS9996.1.
    RefSeqi NP_060425.2. NM_017955.3.
    NP_663747.1. NM_145701.2.
    UniGenei Hs.34045.

    3D structure databases

    ProteinModelPortali Q9BXL8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 120367. 13 interactions.
    IntActi Q9BXL8. 9 interactions.
    MINTi MINT-8417649.
    STRINGi 9606.ENSP00000337226.

    PTM databases

    PhosphoSitei Q9BXL8.

    Polymorphism databases

    DMDMi 32699606.

    Proteomic databases

    MaxQBi Q9BXL8.
    PaxDbi Q9BXL8.
    PRIDEi Q9BXL8.

    Protocols and materials databases

    DNASUi 55038.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000336219 ; ENSP00000337226 ; ENSG00000170779 .
    ENST00000392590 ; ENSP00000376369 ; ENSG00000170779 .
    GeneIDi 55038.
    KEGGi hsa:55038.
    UCSCi uc001yqa.2. human.

    Organism-specific databases

    CTDi 55038.
    GeneCardsi GC14M105598.
    H-InvDB HIX0172337.
    HGNCi HGNC:14625. CDCA4.
    HPAi HPA059416.
    MIMi 612270. gene.
    neXtProti NX_Q9BXL8.
    PharmGKBi PA26277.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG42395.
    HOGENOMi HOG000111497.
    HOVERGENi HBG050861.
    InParanoidi Q9BXL8.
    OMAi TQDGTWQ.
    OrthoDBi EOG7PCJHX.
    PhylomeDBi Q9BXL8.
    TreeFami TF101069.

    Miscellaneous databases

    ChiTaRSi CDCA4. human.
    GenomeRNAii 55038.
    NextBioi 58485.
    PROi Q9BXL8.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9BXL8.
    CleanExi HS_CDCA4.
    Genevestigatori Q9BXL8.

    Family and domain databases

    InterProi IPR009263. SERTA_dom.
    [Graphical view ]
    Pfami PF06031. SERTA. 1 hit.
    [Graphical view ]
    PROSITEi PS51053. SERTA. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and characterization of HEPP, a novel gene expressed preferentially in hematopoietic progenitors and mature blood cells."
      Abdullah J.M., Jing X., Spassov D.S., Nachtman R.G., Jurecic R.
      Blood Cells Mol. Dis. 27:667-676(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: B-cell and Skin.
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 31-241.
      Tissue: Colon.
    4. "CDCA4 is an E2F transcription factor family-induced nuclear factor that regulates E2F-dependent transcriptional activation and cell proliferation."
      Hayashi R., Goto Y., Ikeda R., Yokoyama K.K., Yoshida K.
      J. Biol. Chem. 281:35633-35648(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INDUCTION.

    Entry informationi

    Entry nameiCDCA4_HUMAN
    AccessioniPrimary (citable) accession number: Q9BXL8
    Secondary accession number(s): Q8TB18, Q9NWK7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 11, 2003
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 91 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 14
      Human chromosome 14: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3