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Protein

Cell division cycle-associated protein 4

Gene

CDCA4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May participate in the regulation of cell proliferation through the E2F/RB pathway. May be involved in molecular regulation of hematopoietic stem cells and progenitor cell lineage commitment and differentiation (By similarity).By similarity

Names & Taxonomyi

Protein namesi
Recommended name:
Cell division cycle-associated protein 4
Alternative name(s):
Hematopoietic progenitor protein
Gene namesi
Name:CDCA4
Synonyms:HEPP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 14

Organism-specific databases

HGNCiHGNC:14625. CDCA4.

Subcellular locationi

Nucleus 1 Publication

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA26277.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 241241Cell division cycle-associated protein 4PRO_0000191617Add
BLAST

Proteomic databases

MaxQBiQ9BXL8.
PaxDbiQ9BXL8.
PRIDEiQ9BXL8.

PTM databases

PhosphoSiteiQ9BXL8.

Expressioni

Tissue specificityi

Highest levels of expression in the pancreas, thymus, testis, spleen, liver, placenta and leukocytes. Relatively low levels in the lung, kidney, prostate, ovary, small intestine and colon. Hardly detectable, if at all, in the brain, skeletal muscle and heart.1 Publication

Inductioni

By E2F1.1 Publication

Gene expression databases

BgeeiQ9BXL8.
CleanExiHS_CDCA4.
ExpressionAtlasiQ9BXL8. baseline and differential.
GenevestigatoriQ9BXL8.

Organism-specific databases

HPAiHPA059416.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
KDM1AO603412EBI-1773949,EBI-710124
PRMT6Q96LA82EBI-1773949,EBI-912440
SUV39H1O434632EBI-1773949,EBI-349968
SUV39H2Q9H5I12EBI-1773949,EBI-723127

Protein-protein interaction databases

BioGridi120367. 13 interactions.
IntActiQ9BXL8. 9 interactions.
MINTiMINT-8417649.
STRINGi9606.ENSP00000337226.

Structurei

3D structure databases

ProteinModelPortaliQ9BXL8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini30 – 7748SERTAPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 SERTA domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG42395.
GeneTreeiENSGT00530000063867.
HOGENOMiHOG000111497.
HOVERGENiHBG050861.
InParanoidiQ9BXL8.
OMAiTQDGTWQ.
OrthoDBiEOG7PCJHX.
PhylomeDBiQ9BXL8.
TreeFamiTF101069.

Family and domain databases

InterProiIPR009263. SERTA_dom.
[Graphical view]
PfamiPF06031. SERTA. 1 hit.
[Graphical view]
PROSITEiPS51053. SERTA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9BXL8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFARGLKRKC VGHEEDVEGA LAGLKTVSSY SLQRQSLLDM SLVKLQLCHM
60 70 80 90 100
LVEPNLCRSV LIANTVRQIQ EEMTQDGTWR TVAPQAAERA PLDRLVSTEI
110 120 130 140 150
LCRAAWGQEG AHPAPGLGDG HTQGPVSDLC PVTSAQAPRH LQSSAWEMDG
160 170 180 190 200
PRENRGSFHK SLDQIFETLE TKNPSCMEEL FSDVDSPYYD LDTVLTGMMG
210 220 230 240
GARPGPCEGL EGLAPATPGP SSSCKSDLGE LDHVVEILVE T
Length:241
Mass (Da):26,114
Last modified:June 1, 2001 - v1
Checksum:i9693647E77865D7A
GO

Sequence cautioni

The sequence BAA91373.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti93 – 931D → N in AAH25263 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF322239 mRNA. Translation: AAK31075.1.
BC011736 mRNA. Translation: AAH11736.1.
BC025263 mRNA. Translation: AAH25263.1.
AK000771 mRNA. Translation: BAA91373.1. Different initiation.
CCDSiCCDS9996.1.
RefSeqiNP_060425.2. NM_017955.3.
NP_663747.1. NM_145701.2.
UniGeneiHs.34045.

Genome annotation databases

EnsembliENST00000336219; ENSP00000337226; ENSG00000170779.
ENST00000392590; ENSP00000376369; ENSG00000170779.
GeneIDi55038.
KEGGihsa:55038.
UCSCiuc001yqa.2. human.

Polymorphism databases

DMDMi32699606.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF322239 mRNA. Translation: AAK31075.1.
BC011736 mRNA. Translation: AAH11736.1.
BC025263 mRNA. Translation: AAH25263.1.
AK000771 mRNA. Translation: BAA91373.1. Different initiation.
CCDSiCCDS9996.1.
RefSeqiNP_060425.2. NM_017955.3.
NP_663747.1. NM_145701.2.
UniGeneiHs.34045.

3D structure databases

ProteinModelPortaliQ9BXL8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120367. 13 interactions.
IntActiQ9BXL8. 9 interactions.
MINTiMINT-8417649.
STRINGi9606.ENSP00000337226.

PTM databases

PhosphoSiteiQ9BXL8.

Polymorphism databases

DMDMi32699606.

Proteomic databases

MaxQBiQ9BXL8.
PaxDbiQ9BXL8.
PRIDEiQ9BXL8.

Protocols and materials databases

DNASUi55038.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000336219; ENSP00000337226; ENSG00000170779.
ENST00000392590; ENSP00000376369; ENSG00000170779.
GeneIDi55038.
KEGGihsa:55038.
UCSCiuc001yqa.2. human.

Organism-specific databases

CTDi55038.
GeneCardsiGC14M105605.
H-InvDBHIX0172337.
HGNCiHGNC:14625. CDCA4.
HPAiHPA059416.
MIMi612270. gene.
neXtProtiNX_Q9BXL8.
PharmGKBiPA26277.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG42395.
GeneTreeiENSGT00530000063867.
HOGENOMiHOG000111497.
HOVERGENiHBG050861.
InParanoidiQ9BXL8.
OMAiTQDGTWQ.
OrthoDBiEOG7PCJHX.
PhylomeDBiQ9BXL8.
TreeFamiTF101069.

Miscellaneous databases

ChiTaRSiCDCA4. human.
GenomeRNAii55038.
NextBioi58485.
PROiQ9BXL8.
SOURCEiSearch...

Gene expression databases

BgeeiQ9BXL8.
CleanExiHS_CDCA4.
ExpressionAtlasiQ9BXL8. baseline and differential.
GenevestigatoriQ9BXL8.

Family and domain databases

InterProiIPR009263. SERTA_dom.
[Graphical view]
PfamiPF06031. SERTA. 1 hit.
[Graphical view]
PROSITEiPS51053. SERTA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and characterization of HEPP, a novel gene expressed preferentially in hematopoietic progenitors and mature blood cells."
    Abdullah J.M., Jing X., Spassov D.S., Nachtman R.G., Jurecic R.
    Blood Cells Mol. Dis. 27:667-676(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: B-cell and Skin.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 31-241.
    Tissue: Colon.
  4. "CDCA4 is an E2F transcription factor family-induced nuclear factor that regulates E2F-dependent transcriptional activation and cell proliferation."
    Hayashi R., Goto Y., Ikeda R., Yokoyama K.K., Yoshida K.
    J. Biol. Chem. 281:35633-35648(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INDUCTION.

Entry informationi

Entry nameiCDCA4_HUMAN
AccessioniPrimary (citable) accession number: Q9BXL8
Secondary accession number(s): Q8TB18, Q9NWK7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2003
Last sequence update: June 1, 2001
Last modified: January 7, 2015
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.