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Protein

Cell division cycle-associated protein 4

Gene

CDCA4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May participate in the regulation of cell proliferation through the E2F/RB pathway. May be involved in molecular regulation of hematopoietic stem cells and progenitor cell lineage commitment and differentiation (By similarity).By similarity1 Publication

Names & Taxonomyi

Protein namesi
Recommended name:
Cell division cycle-associated protein 4
Alternative name(s):
Hematopoietic progenitor protein
Gene namesi
Name:CDCA4
Synonyms:HEPP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

EuPathDBiHostDB:ENSG00000170779.10
HGNCiHGNC:14625 CDCA4
MIMi612270 gene
neXtProtiNX_Q9BXL8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi55038
OpenTargetsiENSG00000170779
PharmGKBiPA26277

Polymorphism and mutation databases

BioMutaiCDCA4
DMDMi32699606

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001916171 – 241Cell division cycle-associated protein 4Add BLAST241

Proteomic databases

EPDiQ9BXL8
MaxQBiQ9BXL8
PaxDbiQ9BXL8
PeptideAtlasiQ9BXL8
PRIDEiQ9BXL8

PTM databases

iPTMnetiQ9BXL8
PhosphoSitePlusiQ9BXL8

Expressioni

Tissue specificityi

Highest levels of expression in the pancreas, thymus, testis, spleen, liver, placenta and leukocytes. Relatively low levels in the lung, kidney, prostate, ovary, small intestine and colon. Hardly detectable, if at all, in the brain, skeletal muscle and heart.1 Publication

Inductioni

By E2F1.1 Publication

Gene expression databases

BgeeiENSG00000170779
CleanExiHS_CDCA4
ExpressionAtlasiQ9BXL8 baseline and differential
GenevisibleiQ9BXL8 HS

Organism-specific databases

HPAiHPA059416
HPA064971

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi120367, 24 interactors
IntActiQ9BXL8, 29 interactors
MINTiQ9BXL8
STRINGi9606.ENSP00000337226

Structurei

3D structure databases

ProteinModelPortaliQ9BXL8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini30 – 77SERTAPROSITE-ProRule annotationAdd BLAST48

Phylogenomic databases

eggNOGiENOG410IM11 Eukaryota
ENOG4111IXT LUCA
GeneTreeiENSGT00530000063867
HOGENOMiHOG000111497
HOVERGENiHBG050861
InParanoidiQ9BXL8
OMAiQEEMTQD
OrthoDBiEOG091G0HZO
PhylomeDBiQ9BXL8
TreeFamiTF101069

Family and domain databases

InterProiView protein in InterPro
IPR009263 SERTA_dom
PfamiView protein in Pfam
PF06031 SERTA, 1 hit
PROSITEiView protein in PROSITE
PS51053 SERTA, 1 hit

Sequencei

Sequence statusi: Complete.

Q9BXL8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFARGLKRKC VGHEEDVEGA LAGLKTVSSY SLQRQSLLDM SLVKLQLCHM
60 70 80 90 100
LVEPNLCRSV LIANTVRQIQ EEMTQDGTWR TVAPQAAERA PLDRLVSTEI
110 120 130 140 150
LCRAAWGQEG AHPAPGLGDG HTQGPVSDLC PVTSAQAPRH LQSSAWEMDG
160 170 180 190 200
PRENRGSFHK SLDQIFETLE TKNPSCMEEL FSDVDSPYYD LDTVLTGMMG
210 220 230 240
GARPGPCEGL EGLAPATPGP SSSCKSDLGE LDHVVEILVE T
Length:241
Mass (Da):26,114
Last modified:June 1, 2001 - v1
Checksum:i9693647E77865D7A
GO

Sequence cautioni

The sequence BAA91373 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti93D → N in AAH25263 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF322239 mRNA Translation: AAK31075.1
BC011736 mRNA Translation: AAH11736.1
BC025263 mRNA Translation: AAH25263.1
AK000771 mRNA Translation: BAA91373.1 Different initiation.
CCDSiCCDS9996.1
RefSeqiNP_060425.2, NM_017955.3
NP_663747.1, NM_145701.2
UniGeneiHs.34045

Genome annotation databases

EnsembliENST00000336219; ENSP00000337226; ENSG00000170779
ENST00000392590; ENSP00000376369; ENSG00000170779
GeneIDi55038
KEGGihsa:55038
UCSCiuc001yqa.3 human

Similar proteinsi

Entry informationi

Entry nameiCDCA4_HUMAN
AccessioniPrimary (citable) accession number: Q9BXL8
Secondary accession number(s): Q8TB18, Q9NWK7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2003
Last sequence update: June 1, 2001
Last modified: May 23, 2018
This is version 119 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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