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Q9BXL8

- CDCA4_HUMAN

UniProt

Q9BXL8 - CDCA4_HUMAN

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Protein
Cell division cycle-associated protein 4
Gene
CDCA4, HEPP
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

May participate in the regulation of cell proliferation through the E2F/RB pathway. May be involved in molecular regulation of hematopoietic stem cells and progenitor cell lineage commitment and differentiation By similarity.1 Publication

GO - Molecular functioni

  1. protein binding Source: IntAct
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Cell division cycle-associated protein 4
Alternative name(s):
Hematopoietic progenitor protein
Gene namesi
Name:CDCA4
Synonyms:HEPP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 14

Organism-specific databases

HGNCiHGNC:14625. CDCA4.

Subcellular locationi

Nucleus 1 Publication

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA26277.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 241241Cell division cycle-associated protein 4
PRO_0000191617Add
BLAST

Proteomic databases

MaxQBiQ9BXL8.
PaxDbiQ9BXL8.
PRIDEiQ9BXL8.

PTM databases

PhosphoSiteiQ9BXL8.

Expressioni

Tissue specificityi

Highest levels of expression in the pancreas, thymus, testis, spleen, liver, placenta and leukocytes. Relatively low levels in the lung, kidney, prostate, ovary, small intestine and colon. Hardly detectable, if at all, in the brain, skeletal muscle and heart.1 Publication

Inductioni

By E2F1.1 Publication

Gene expression databases

BgeeiQ9BXL8.
CleanExiHS_CDCA4.
GenevestigatoriQ9BXL8.

Organism-specific databases

HPAiHPA059416.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
KDM1AO603412EBI-1773949,EBI-710124
PRMT6Q96LA82EBI-1773949,EBI-912440
SUV39H1O434632EBI-1773949,EBI-349968
SUV39H2Q9H5I12EBI-1773949,EBI-723127

Protein-protein interaction databases

BioGridi120367. 13 interactions.
IntActiQ9BXL8. 9 interactions.
MINTiMINT-8417649.
STRINGi9606.ENSP00000337226.

Structurei

3D structure databases

ProteinModelPortaliQ9BXL8.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini30 – 7748SERTA
Add
BLAST

Sequence similaritiesi

Contains 1 SERTA domain.

Phylogenomic databases

eggNOGiNOG42395.
HOGENOMiHOG000111497.
HOVERGENiHBG050861.
InParanoidiQ9BXL8.
OMAiTQDGTWQ.
OrthoDBiEOG7PCJHX.
PhylomeDBiQ9BXL8.
TreeFamiTF101069.

Family and domain databases

InterProiIPR009263. SERTA_dom.
[Graphical view]
PfamiPF06031. SERTA. 1 hit.
[Graphical view]
PROSITEiPS51053. SERTA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9BXL8-1 [UniParc]FASTAAdd to Basket

« Hide

MFARGLKRKC VGHEEDVEGA LAGLKTVSSY SLQRQSLLDM SLVKLQLCHM    50
LVEPNLCRSV LIANTVRQIQ EEMTQDGTWR TVAPQAAERA PLDRLVSTEI 100
LCRAAWGQEG AHPAPGLGDG HTQGPVSDLC PVTSAQAPRH LQSSAWEMDG 150
PRENRGSFHK SLDQIFETLE TKNPSCMEEL FSDVDSPYYD LDTVLTGMMG 200
GARPGPCEGL EGLAPATPGP SSSCKSDLGE LDHVVEILVE T 241
Length:241
Mass (Da):26,114
Last modified:June 1, 2001 - v1
Checksum:i9693647E77865D7A
GO

Sequence cautioni

The sequence BAA91373.1 differs from that shown. Reason: Erroneous initiation.

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti93 – 931D → N in AAH25263. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF322239 mRNA. Translation: AAK31075.1.
BC011736 mRNA. Translation: AAH11736.1.
BC025263 mRNA. Translation: AAH25263.1.
AK000771 mRNA. Translation: BAA91373.1. Different initiation.
CCDSiCCDS9996.1.
RefSeqiNP_060425.2. NM_017955.3.
NP_663747.1. NM_145701.2.
UniGeneiHs.34045.

Genome annotation databases

EnsembliENST00000336219; ENSP00000337226; ENSG00000170779.
ENST00000392590; ENSP00000376369; ENSG00000170779.
GeneIDi55038.
KEGGihsa:55038.
UCSCiuc001yqa.2. human.

Polymorphism databases

DMDMi32699606.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF322239 mRNA. Translation: AAK31075.1 .
BC011736 mRNA. Translation: AAH11736.1 .
BC025263 mRNA. Translation: AAH25263.1 .
AK000771 mRNA. Translation: BAA91373.1 . Different initiation.
CCDSi CCDS9996.1.
RefSeqi NP_060425.2. NM_017955.3.
NP_663747.1. NM_145701.2.
UniGenei Hs.34045.

3D structure databases

ProteinModelPortali Q9BXL8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 120367. 13 interactions.
IntActi Q9BXL8. 9 interactions.
MINTi MINT-8417649.
STRINGi 9606.ENSP00000337226.

PTM databases

PhosphoSitei Q9BXL8.

Polymorphism databases

DMDMi 32699606.

Proteomic databases

MaxQBi Q9BXL8.
PaxDbi Q9BXL8.
PRIDEi Q9BXL8.

Protocols and materials databases

DNASUi 55038.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000336219 ; ENSP00000337226 ; ENSG00000170779 .
ENST00000392590 ; ENSP00000376369 ; ENSG00000170779 .
GeneIDi 55038.
KEGGi hsa:55038.
UCSCi uc001yqa.2. human.

Organism-specific databases

CTDi 55038.
GeneCardsi GC14M105598.
H-InvDB HIX0172337.
HGNCi HGNC:14625. CDCA4.
HPAi HPA059416.
MIMi 612270. gene.
neXtProti NX_Q9BXL8.
PharmGKBi PA26277.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG42395.
HOGENOMi HOG000111497.
HOVERGENi HBG050861.
InParanoidi Q9BXL8.
OMAi TQDGTWQ.
OrthoDBi EOG7PCJHX.
PhylomeDBi Q9BXL8.
TreeFami TF101069.

Miscellaneous databases

ChiTaRSi CDCA4. human.
GenomeRNAii 55038.
NextBioi 58485.
PROi Q9BXL8.
SOURCEi Search...

Gene expression databases

Bgeei Q9BXL8.
CleanExi HS_CDCA4.
Genevestigatori Q9BXL8.

Family and domain databases

InterProi IPR009263. SERTA_dom.
[Graphical view ]
Pfami PF06031. SERTA. 1 hit.
[Graphical view ]
PROSITEi PS51053. SERTA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and characterization of HEPP, a novel gene expressed preferentially in hematopoietic progenitors and mature blood cells."
    Abdullah J.M., Jing X., Spassov D.S., Nachtman R.G., Jurecic R.
    Blood Cells Mol. Dis. 27:667-676(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: B-cell and Skin.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 31-241.
    Tissue: Colon.
  4. "CDCA4 is an E2F transcription factor family-induced nuclear factor that regulates E2F-dependent transcriptional activation and cell proliferation."
    Hayashi R., Goto Y., Ikeda R., Yokoyama K.K., Yoshida K.
    J. Biol. Chem. 281:35633-35648(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INDUCTION.

Entry informationi

Entry nameiCDCA4_HUMAN
AccessioniPrimary (citable) accession number: Q9BXL8
Secondary accession number(s): Q8TB18, Q9NWK7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2003
Last sequence update: June 1, 2001
Last modified: July 9, 2014
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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