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Q9BXL8 (CDCA4_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 87. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cell division cycle-associated protein 4
Alternative name(s):
Hematopoietic progenitor protein
Gene names
Name:CDCA4
Synonyms:HEPP
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length241 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May participate in the regulation of cell proliferation through the E2F/RB pathway. May be involved in molecular regulation of hematopoietic stem cells and progenitor cell lineage commitment and differentiation By similarity. Ref.4

Subcellular location

Nucleus Ref.4.

Tissue specificity

Highest levels of expression in the pancreas, thymus, testis, spleen, liver, placenta and leukocytes. Relatively low levels in the lung, kidney, prostate, ovary, small intestine and colon. Hardly detectable, if at all, in the brain, skeletal muscle and heart. Ref.4

Induction

By E2F1. Ref.4

Sequence similarities

Contains 1 SERTA domain.

Sequence caution

The sequence BAA91373.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Cellular componentNucleus
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 241241Cell division cycle-associated protein 4
PRO_0000191617

Regions

Domain30 – 7748SERTA

Experimental info

Sequence conflict931D → N in AAH25263. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q9BXL8 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: 9693647E77865D7A

FASTA24126,114
        10         20         30         40         50         60 
MFARGLKRKC VGHEEDVEGA LAGLKTVSSY SLQRQSLLDM SLVKLQLCHM LVEPNLCRSV 

        70         80         90        100        110        120 
LIANTVRQIQ EEMTQDGTWR TVAPQAAERA PLDRLVSTEI LCRAAWGQEG AHPAPGLGDG 

       130        140        150        160        170        180 
HTQGPVSDLC PVTSAQAPRH LQSSAWEMDG PRENRGSFHK SLDQIFETLE TKNPSCMEEL 

       190        200        210        220        230        240 
FSDVDSPYYD LDTVLTGMMG GARPGPCEGL EGLAPATPGP SSSCKSDLGE LDHVVEILVE 


T 

« Hide

References

« Hide 'large scale' references
[1]"Cloning and characterization of HEPP, a novel gene expressed preferentially in hematopoietic progenitors and mature blood cells."
Abdullah J.M., Jing X., Spassov D.S., Nachtman R.G., Jurecic R.
Blood Cells Mol. Dis. 27:667-676(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: B-cell and Skin.
[3]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 31-241.
Tissue: Colon.
[4]"CDCA4 is an E2F transcription factor family-induced nuclear factor that regulates E2F-dependent transcriptional activation and cell proliferation."
Hayashi R., Goto Y., Ikeda R., Yokoyama K.K., Yoshida K.
J. Biol. Chem. 281:35633-35648(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INDUCTION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF322239 mRNA. Translation: AAK31075.1.
BC011736 mRNA. Translation: AAH11736.1.
BC025263 mRNA. Translation: AAH25263.1.
AK000771 mRNA. Translation: BAA91373.1. Different initiation.
RefSeqNP_060425.2. NM_017955.3.
NP_663747.1. NM_145701.2.
UniGeneHs.34045.

3D structure databases

ProteinModelPortalQ9BXL8.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid120367. 13 interactions.
IntActQ9BXL8. 9 interactions.
MINTMINT-8417649.
STRING9606.ENSP00000337226.

PTM databases

PhosphoSiteQ9BXL8.

Polymorphism databases

DMDM32699606.

Proteomic databases

PaxDbQ9BXL8.
PRIDEQ9BXL8.

Protocols and materials databases

DNASU55038.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000336219; ENSP00000337226; ENSG00000170779.
ENST00000392590; ENSP00000376369; ENSG00000170779.
GeneID55038.
KEGGhsa:55038.
UCSCuc001yqa.2. human.

Organism-specific databases

CTD55038.
GeneCardsGC14M105598.
H-InvDBHIX0172337.
HGNCHGNC:14625. CDCA4.
HPAHPA059416.
MIM612270. gene.
neXtProtNX_Q9BXL8.
PharmGKBPA26277.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG42395.
HOGENOMHOG000111497.
HOVERGENHBG050861.
InParanoidQ9BXL8.
OMATQDGTWQ.
OrthoDBEOG7PCJHX.
PhylomeDBQ9BXL8.
TreeFamTF101069.

Gene expression databases

BgeeQ9BXL8.
CleanExHS_CDCA4.
GenevestigatorQ9BXL8.

Family and domain databases

InterProIPR009263. SERTA.
[Graphical view]
PANTHERPTHR16277. PTHR16277. 1 hit.
PfamPF06031. SERTA. 1 hit.
[Graphical view]
PROSITEPS51053. SERTA. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSCDCA4. human.
GenomeRNAi55038.
NextBio58485.
PROQ9BXL8.
SOURCESearch...

Entry information

Entry nameCDCA4_HUMAN
AccessionPrimary (citable) accession number: Q9BXL8
Secondary accession number(s): Q8TB18, Q9NWK7
Entry history
Integrated into UniProtKB/Swiss-Prot: July 11, 2003
Last sequence update: June 1, 2001
Last modified: April 16, 2014
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 14

Human chromosome 14: entries, gene names and cross-references to MIM