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Protein

Cell division cycle-associated protein 4

Gene

CDCA4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May participate in the regulation of cell proliferation through the E2F/RB pathway. May be involved in molecular regulation of hematopoietic stem cells and progenitor cell lineage commitment and differentiation (By similarity).By similarity1 Publication

Names & Taxonomyi

Protein namesi
Recommended name:
Cell division cycle-associated protein 4
Alternative name(s):
Hematopoietic progenitor protein
Gene namesi
Name:CDCA4
Synonyms:HEPP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

HGNCiHGNC:14625. CDCA4.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000170779.
PharmGKBiPA26277.

Polymorphism and mutation databases

BioMutaiCDCA4.
DMDMi32699606.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001916171 – 241Cell division cycle-associated protein 4Add BLAST241

Proteomic databases

EPDiQ9BXL8.
MaxQBiQ9BXL8.
PaxDbiQ9BXL8.
PeptideAtlasiQ9BXL8.
PRIDEiQ9BXL8.

PTM databases

iPTMnetiQ9BXL8.
PhosphoSitePlusiQ9BXL8.

Expressioni

Tissue specificityi

Highest levels of expression in the pancreas, thymus, testis, spleen, liver, placenta and leukocytes. Relatively low levels in the lung, kidney, prostate, ovary, small intestine and colon. Hardly detectable, if at all, in the brain, skeletal muscle and heart.1 Publication

Inductioni

By E2F1.1 Publication

Gene expression databases

BgeeiENSG00000170779.
CleanExiHS_CDCA4.
ExpressionAtlasiQ9BXL8. baseline and differential.
GenevisibleiQ9BXL8. HS.

Organism-specific databases

HPAiHPA059416.
HPA064971.

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi120367. 24 interactors.
IntActiQ9BXL8. 26 interactors.
MINTiMINT-8417649.
STRINGi9606.ENSP00000337226.

Structurei

3D structure databases

ProteinModelPortaliQ9BXL8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini30 – 77SERTAPROSITE-ProRule annotationAdd BLAST48

Phylogenomic databases

eggNOGiENOG410IM11. Eukaryota.
ENOG4111IXT. LUCA.
GeneTreeiENSGT00530000063867.
HOGENOMiHOG000111497.
HOVERGENiHBG050861.
InParanoidiQ9BXL8.
OMAiTQDGTWQ.
OrthoDBiEOG091G0HZO.
PhylomeDBiQ9BXL8.
TreeFamiTF101069.

Family and domain databases

InterProiView protein in InterPro
IPR009263. SERTA_dom.
PfamiView protein in Pfam
PF06031. SERTA. 1 hit.
PROSITEiView protein in PROSITE
PS51053. SERTA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9BXL8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFARGLKRKC VGHEEDVEGA LAGLKTVSSY SLQRQSLLDM SLVKLQLCHM
60 70 80 90 100
LVEPNLCRSV LIANTVRQIQ EEMTQDGTWR TVAPQAAERA PLDRLVSTEI
110 120 130 140 150
LCRAAWGQEG AHPAPGLGDG HTQGPVSDLC PVTSAQAPRH LQSSAWEMDG
160 170 180 190 200
PRENRGSFHK SLDQIFETLE TKNPSCMEEL FSDVDSPYYD LDTVLTGMMG
210 220 230 240
GARPGPCEGL EGLAPATPGP SSSCKSDLGE LDHVVEILVE T
Length:241
Mass (Da):26,114
Last modified:June 1, 2001 - v1
Checksum:i9693647E77865D7A
GO

Sequence cautioni

The sequence BAA91373 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti93D → N in AAH25263 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF322239 mRNA. Translation: AAK31075.1.
BC011736 mRNA. Translation: AAH11736.1.
BC025263 mRNA. Translation: AAH25263.1.
AK000771 mRNA. Translation: BAA91373.1. Different initiation.
CCDSiCCDS9996.1.
RefSeqiNP_060425.2. NM_017955.3.
NP_663747.1. NM_145701.2.
UniGeneiHs.34045.

Genome annotation databases

EnsembliENST00000336219; ENSP00000337226; ENSG00000170779.
ENST00000392590; ENSP00000376369; ENSG00000170779.
GeneIDi55038.
KEGGihsa:55038.
UCSCiuc001yqa.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF322239 mRNA. Translation: AAK31075.1.
BC011736 mRNA. Translation: AAH11736.1.
BC025263 mRNA. Translation: AAH25263.1.
AK000771 mRNA. Translation: BAA91373.1. Different initiation.
CCDSiCCDS9996.1.
RefSeqiNP_060425.2. NM_017955.3.
NP_663747.1. NM_145701.2.
UniGeneiHs.34045.

3D structure databases

ProteinModelPortaliQ9BXL8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120367. 24 interactors.
IntActiQ9BXL8. 26 interactors.
MINTiMINT-8417649.
STRINGi9606.ENSP00000337226.

PTM databases

iPTMnetiQ9BXL8.
PhosphoSitePlusiQ9BXL8.

Polymorphism and mutation databases

BioMutaiCDCA4.
DMDMi32699606.

Proteomic databases

EPDiQ9BXL8.
MaxQBiQ9BXL8.
PaxDbiQ9BXL8.
PeptideAtlasiQ9BXL8.
PRIDEiQ9BXL8.

Protocols and materials databases

DNASUi55038.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000336219; ENSP00000337226; ENSG00000170779.
ENST00000392590; ENSP00000376369; ENSG00000170779.
GeneIDi55038.
KEGGihsa:55038.
UCSCiuc001yqa.3. human.

Organism-specific databases

CTDi55038.
GeneCardsiCDCA4.
H-InvDBHIX0172337.
HGNCiHGNC:14625. CDCA4.
HPAiHPA059416.
HPA064971.
MIMi612270. gene.
neXtProtiNX_Q9BXL8.
OpenTargetsiENSG00000170779.
PharmGKBiPA26277.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IM11. Eukaryota.
ENOG4111IXT. LUCA.
GeneTreeiENSGT00530000063867.
HOGENOMiHOG000111497.
HOVERGENiHBG050861.
InParanoidiQ9BXL8.
OMAiTQDGTWQ.
OrthoDBiEOG091G0HZO.
PhylomeDBiQ9BXL8.
TreeFamiTF101069.

Miscellaneous databases

ChiTaRSiCDCA4. human.
GenomeRNAii55038.
PROiQ9BXL8.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000170779.
CleanExiHS_CDCA4.
ExpressionAtlasiQ9BXL8. baseline and differential.
GenevisibleiQ9BXL8. HS.

Family and domain databases

InterProiView protein in InterPro
IPR009263. SERTA_dom.
PfamiView protein in Pfam
PF06031. SERTA. 1 hit.
PROSITEiView protein in PROSITE
PS51053. SERTA. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiCDCA4_HUMAN
AccessioniPrimary (citable) accession number: Q9BXL8
Secondary accession number(s): Q8TB18, Q9NWK7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2003
Last sequence update: June 1, 2001
Last modified: March 15, 2017
This is version 112 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.