Q9BXL8 (CDCA4_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cell division cycle-associated protein 4

Alternative name(s):
Hematopoietic progenitor protein

Gene names

Name:	CDCA4
Synonyms:	HEPP

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	241 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May participate in the regulation of cell proliferation through the E2F/RB pathway. May be involved in molecular regulation of hematopoietic stem cells and progenitor cell lineage commitment and differentiation By similarity. Ref.4
Subcellular location	Nucleus Ref.4.
Tissue specificity	Highest levels of expression in the pancreas, thymus, testis, spleen, liver, placenta and leukocytes. Relatively low levels in the lung, kidney, prostate, ovary, small intestine and colon. Hardly detectable, if at all, in the brain, skeletal muscle and heart. Ref.4
Induction	By E2F1. Ref.4
Sequence similarities	Contains 1 SERTA domain.
Sequence caution	The sequence BAA91373.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Cellular component	Nucleus
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 241	241	Cell division cycle-associated protein 4		PRO_0000191617
Regions
	Domain	30 – 77	48	SERTA
Experimental info
	Sequence conflict	93	1	D → N in AAH25263. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Q9BXL8 [UniParc]. Last modified June 1, 2001. Version 1. Checksum: 9693647E77865D7A	FASTA	241	26,114
	10 20 30 40 50 60 MFARGLKRKC VGHEEDVEGA LAGLKTVSSY SLQRQSLLDM SLVKLQLCHM LVEPNLCRSV 70 80 90 100 110 120 LIANTVRQIQ EEMTQDGTWR TVAPQAAERA PLDRLVSTEI LCRAAWGQEG AHPAPGLGDG 130 140 150 160 170 180 HTQGPVSDLC PVTSAQAPRH LQSSAWEMDG PRENRGSFHK SLDQIFETLE TKNPSCMEEL 190 200 210 220 230 240 FSDVDSPYYD LDTVLTGMMG GARPGPCEGL EGLAPATPGP SSSCKSDLGE LDHVVEILVE T

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and characterization of HEPP, a novel gene expressed preferentially in hematopoietic progenitors and mature blood cells." Abdullah J.M., Jing X., Spassov D.S., Nachtman R.G., Jurecic R. Blood Cells Mol. Dis. 27:667-676(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: B-cell and Skin.
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 31-241. Tissue: Colon.
[4]	"CDCA4 is an E2F transcription factor family-induced nuclear factor that regulates E2F-dependent transcriptional activation and cell proliferation." Hayashi R., Goto Y., Ikeda R., Yokoyama K.K., Yoshida K. J. Biol. Chem. 281:35633-35648(2006) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INDUCTION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF322239 mRNA. Translation: AAK31075.1. BC011736 mRNA. Translation: AAH11736.1. BC025263 mRNA. Translation: AAH25263.1. AK000771 mRNA. Translation: BAA91373.1. Different initiation.
IPI	IPI00157358.
RefSeq	NP_060425.2. NM_017955.3. NP_663747.1. NM_145701.2.
UniGene	Hs.34045.
3D structure databases
ProteinModelPortal	Q9BXL8.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9BXL8. 3 interactions.
STRING	9606.ENSP00000337226.
PTM databases
PhosphoSite	Q9BXL8.
Polymorphism databases
DMDM	32699606.
Proteomic databases
PaxDb	Q9BXL8.
PRIDE	Q9BXL8.
Protocols and materials databases
DNASU	55038.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000336219; ENSP00000337226; ENSG00000170779. ENST00000392590; ENSP00000376369; ENSG00000170779.
GeneID	55038.
KEGG	hsa:55038.
UCSC	uc001yqa.2. human.
Organism-specific databases
CTD	55038.
GeneCards	GC14M105576.
H-InvDB	HIX0172337.
HGNC	HGNC:14625. CDCA4.
MIM	612270. gene.
neXtProt	NX_Q9BXL8.
PharmGKB	PA26277.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG42395.
HOGENOM	HOG000111497.
HOVERGEN	HBG050861.
InParanoid	Q9BXL8.
OMA	NSYYDLD.
OrthoDB	EOG4BVRVK.
PhylomeDB	Q9BXL8.
Gene expression databases
Bgee	Q9BXL8.
CleanEx	HS_CDCA4.
Genevestigator	Q9BXL8.
GermOnline	ENSG00000170779. Homo sapiens.
Family and domain databases
InterPro	IPR009263. SERTA. [Graphical view]
PANTHER	PTHR16277. PTHR16277. 1 hit.
Pfam	PF06031. SERTA. 1 hit. [Graphical view]
PROSITE	PS51053. SERTA. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	CDCA4. human.
GenomeRNAi	55038.
NextBio	58485.
SOURCE	Search...

Entry information

Entry name

CDCA4_HUMAN

Accession

Primary (citable) accession number: Q9BXL8
Secondary accession number(s): Q8TB18, Q9NWK7

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 11, 2003
Last sequence update:	June 1, 2001
Last modified:	April 3, 2013
This is version 80 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.