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Q9BXL7

- CAR11_HUMAN

UniProt

Q9BXL7 - CAR11_HUMAN

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Protein
Caspase recruitment domain-containing protein 11
Gene
CARD11, CARMA1
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Activates NF-kappa-B via BCL10 and IKK. Stimulates the phosphorylation of BCL10.

GO - Molecular functioni

  1. CARD domain binding Source: UniProtKB
  2. guanylate kinase activity Source: UniProtKB
  3. protein binding Source: UniProtKB

GO - Biological processi

  1. Fc-epsilon receptor signaling pathway Source: Reactome
  2. T cell costimulation Source: UniProtKB
  3. T cell receptor signaling pathway Source: Reactome
  4. innate immune response Source: Reactome
  5. nucleotide phosphorylation Source: GOC
  6. positive regulation of B cell proliferation Source: Ensembl
  7. positive regulation of I-kappaB kinase/NF-kappaB signaling Source: Ensembl
  8. positive regulation of NF-kappaB transcription factor activity Source: UniProtKB
  9. positive regulation of T cell proliferation Source: Ensembl
  10. positive regulation of cytokine production Source: UniProtKB
  11. positive regulation of interleukin-2 biosynthetic process Source: Ensembl
  12. regulation of B cell differentiation Source: Ensembl
  13. regulation of T cell differentiation Source: Ensembl
  14. regulation of apoptotic process Source: InterPro
  15. thymic T cell selection Source: Ensembl
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_118656. Activation of NF-kappaB in B cells.
REACT_12555. Downstream TCR signaling.
REACT_163994. FCERI mediated NF-kB activation.
SignaLinkiQ9BXL7.

Names & Taxonomyi

Protein namesi
Recommended name:
Caspase recruitment domain-containing protein 11
Alternative name(s):
CARD-containing MAGUK protein 1
Short name:
Carma 1
Gene namesi
Name:CARD11
Synonyms:CARMA1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 7

Organism-specific databases

HGNCiHGNC:16393. CARD11.

Subcellular locationi

Cytoplasm. Membrane raft
Note: Colocalized with DPP4 in membrane rafts.1 Publication

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
  2. cytosol Source: Reactome
  3. membrane raft Source: UniProtKB
  4. plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane

Pathology & Biotechi

Involvement in diseasei

Persistent polyclonal B-cell lymphocytosis (PPBL) [MIM:606445]: An autosomal dominant condition characterized by onset in infancy of splenomegaly and polyclonal expansion of B cells, resulting in peripheral lymphocytosis. Affected individuals also show mild immune dysfunction, including some defective antibody responses and T-cell anergy. There may be a predisposition to the development of B-cell malignancy.
Note: The disease is caused by mutations affecting the gene represented in this entry.1 Publication
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti123 – 1231G → S in PPBL; results in protein aggregation and constitutive NFKB activation. 1 Publication
VAR_069710
Natural varianti134 – 1341E → G in PPBL; results in protein aggregation and constitutive NFKB activation. 1 Publication
VAR_069711
Immunodeficiency 11 (IMD11) [MIM:615206]: An autosomal recessive primary immunodeficiency characterized by normal numbers of T and B-lymphocytes, but defective intracellular signaling. There is a block in B-cell differentiation with increased numbers of transitional B-cells and hypogammaglobulinemia, as well as decreased numbers of regulatory T-cells and defects in T-cell function.
Note: The disease is caused by mutations affecting the gene represented in this entry.1 Publication

Keywords - Diseasei

Disease mutation

Organism-specific databases

MIMi606445. phenotype.
615206. phenotype.
Orphaneti300324. Persistent polyclonal B-cell lymphocytosis.
357237. Severe combined immunodeficiency due to CARD11 deficiency.
PharmGKBiPA26073.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11541154Caspase recruitment domain-containing protein 11
PRO_0000144086Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei466 – 4661Phosphoserine1 Publication
Modified residuei559 – 5591Phosphoserine; by PKC/PRKCB and PKC/PRKCQ By similarity
Modified residuei593 – 5931Phosphoserine1 Publication
Modified residuei644 – 6441Phosphoserine; by PKC/PRKCB and PKC/PRKCQ By similarity
Modified residuei652 – 6521Phosphoserine; by PKC/PRKCB and PKC/PRKCQ By similarity
Modified residuei925 – 9251Phosphoserine1 Publication

Post-translational modificationi

Phosphorylation at Ser-559, Ser-644 and Ser-652 by PRKCB and PRKCQ leads to a shift from an inactive to an active form that activates the NF-kappa-B signaling By similarity.

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9BXL7.
PaxDbiQ9BXL7.
PRIDEiQ9BXL7.

PTM databases

PhosphoSiteiQ9BXL7.

Expressioni

Tissue specificityi

Detected in adult peripheral blood leukocytes, thymus, spleen and liver. Also found in promyelocytic leukemia HL-60 cells, chronic myelogenous leukemia K-562 cells, Burkitt's lymphoma Raji cells and colorectal adenocarcinoma SW480 cells. Not detected in HeLaS3, MOLT-4, A-549 and G431 cells.1 Publication

Gene expression databases

ArrayExpressiQ9BXL7.
BgeeiQ9BXL7.
CleanExiHS_CARD11.
GenevestigatoriQ9BXL7.

Organism-specific databases

HPAiHPA052984.

Interactioni

Subunit structurei

Found in a membrane raft complex, at least composed of BCL10, CARD11, DPP4 and IKBKB. CARD11 and BCL10 bind to each other by CARD-CARD interaction. Interacts (via PDZ domain) with DPP4 (via cytoplasmic tail).1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
BCL10O959994EBI-7006141,EBI-958922

Protein-protein interaction databases

BioGridi124073. 21 interactions.
DIPiDIP-41797N.
IntActiQ9BXL7. 7 interactions.
MINTiMINT-193901.
STRINGi9606.ENSP00000380150.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi24 – 274
Helixi30 – 367
Helixi39 – 4810
Helixi54 – 618
Turni70 – 734
Helixi74 – 807
Helixi84 – 9815
Helixi100 – 1078

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4JUPX-ray3.20A/B21-116[»]
4LWDX-ray1.79A18-110[»]
ProteinModelPortaliQ9BXL7.
SMRiQ9BXL7. Positions 21-110, 673-845.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini18 – 11093CARD
Add
BLAST
Domaini667 – 75589PDZ
Add
BLAST
Domaini973 – 1140168Guanylate kinase-like
Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili130 – 449320 Reviewed prediction
Add
BLAST

Sequence similaritiesi

Contains 1 CARD domain.
Contains 1 PDZ (DHR) domain.

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG47732.
HOVERGENiHBG099790.
InParanoidiQ9BXL7.
KOiK07367.
OMAiEALPCLY.
OrthoDBiEOG747PH5.
PhylomeDBiQ9BXL7.
TreeFamiTF351139.

Family and domain databases

Gene3Di1.10.533.10. 1 hit.
2.30.42.10. 1 hit.
3.40.50.300. 2 hits.
InterProiIPR001315. CARD.
IPR011029. DEATH-like_dom.
IPR027417. P-loop_NTPase.
IPR001478. PDZ.
[Graphical view]
PfamiPF00619. CARD. 1 hit.
[Graphical view]
SMARTiSM00228. PDZ. 1 hit.
[Graphical view]
SUPFAMiSSF47986. SSF47986. 1 hit.
SSF50156. SSF50156. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEiPS50209. CARD. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9BXL7-1 [UniParc]FASTAAdd to Basket

« Hide

MPGGGPEMDD YMETLKDEED ALWENVECNR HMLSRYINPA KLTPYLRQCK     50
VIDEQDEDEV LNAPMLPSKI NRAGRLLDIL HTKGQRGYVV FLESLEFYYP 100
ELYKLVTGKE PTRRFSTIVV EEGHEGLTHF LMNEVIKLQQ QMKAKDLQRC 150
ELLARLRQLE DEKKQMTLTR VELLTFQERY YKMKEERDSY NDELVKVKDD 200
NYNLAMRYAQ LSEEKNMAVM RSRDLQLEID QLKHRLNKME EECKLERNQS 250
LKLKNDIENR PKKEQVLELE RENEMLKTKN QELQSIIQAG KRSLPDSDKA 300
ILDILEHDRK EALEDRQELV NRIYNLQEEA RQAEELRDKY LEEKEDLELK 350
CSTLGKDCEM YKHRMNTVML QLEEVERERD QAFHSRDEAQ TQYSQCLIEK 400
DKYRKQIREL EEKNDEMRIE MVRREACIVN LESKLRRLSK DSNNLDQSLP 450
RNLPVTIISQ DFGDASPRTN GQEADDSSTS EESPEDSKYF LPYHPPQRRM 500
NLKGIQLQRA KSPISLKRTS DFQAKGHEEE GTDASPSSCG SLPITNSFTK 550
MQPPRSRSSI MSITAEPPGN DSIVRRYKED APHRSTVEED NDSGGFDALD 600
LDDDSHERYS FGPSSIHSSS SSHQSEGLDA YDLEQVNLMF RKFSLERPFR 650
PSVTSVGHVR GPGPSVQHTT LNGDSLTSQL TLLGGNARGS FVHSVKPGSL 700
AEKAGLREGH QLLLLEGCIR GERQSVPLDT CTKEEAHWTI QRCSGPVTLH 750
YKVNHEGYRK LVKDMEDGLI TSGDSFYIRL NLNISSQLDA CTMSLKCDDV 800
VHVRDTMYQD RHEWLCARVD PFTDHDLDMG TIPSYSRAQQ LLLVKLQRLM 850
HRGSREEVDG THHTLRALRN TLQPEEALST SDPRVSPRLS RASFLFGQLL 900
QFVSRSENKY KRMNSNERVR IISGSPLGSL ARSSLDATKL LTEKQEELDP 950
ESELGKNLSL IPYSLVRAFY CERRRPVLFT PTVLAKTLVQ RLLNSGGAME 1000
FTICKSDIVT RDEFLRRQKT ETIIYSREKN PNAFECIAPA NIEAVAAKNK 1050
HCLLEAGIGC TRDLIKSNIY PIVLFIRVCE KNIKRFRKLL PRPETEEEFL 1100
RVCRLKEKEL EALPCLYATV EPDMWGSVEE LLRVVKDKIG EEQRKTIWVD 1150
EDQL 1154
Length:1,154
Mass (Da):133,284
Last modified:February 26, 2008 - v3
Checksum:i2F3512D903795D18
GO

Sequence cautioni

The sequence AAG53402.1 differs from that shown. Reason: Erroneous initiation.
The sequence AAI11720.2 differs from that shown. Reason: Erroneous initiation.
The sequence AAQ96893.1 differs from that shown. Reason: Erroneous gene model prediction.
The sequence EAL23962.1 differs from that shown. Reason: Erroneous gene model prediction.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti123 – 1231G → S in PPBL; results in protein aggregation and constitutive NFKB activation. 1 Publication
VAR_069710
Natural varianti134 – 1341E → G in PPBL; results in protein aggregation and constitutive NFKB activation. 1 Publication
VAR_069711
Natural varianti670 – 6701T → M.
Corresponds to variant rs3735134 [ dbSNP | Ensembl ].
VAR_028117
Natural varianti694 – 6941S → L.
Corresponds to variant rs3735133 [ dbSNP | Ensembl ].
VAR_028118

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti815 – 8151L → P in AAG53402. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF322641 mRNA. Translation: AAG53402.1. Different initiation.
AC004906 Genomic DNA. Translation: AAQ96893.1. Sequence problems.
CH236953 Genomic DNA. Translation: EAL23962.1. Sequence problems.
BC111719 mRNA. Translation: AAI11720.2. Different initiation.
AF352576 mRNA. Translation: AAL34460.1.
CCDSiCCDS5336.2.
RefSeqiNP_115791.3. NM_032415.5.
UniGeneiHs.648101.

Genome annotation databases

EnsembliENST00000396946; ENSP00000380150; ENSG00000198286.
GeneIDi84433.
KEGGihsa:84433.
UCSCiuc003smv.3. human.

Polymorphism databases

DMDMi172046231.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF322641 mRNA. Translation: AAG53402.1 . Different initiation.
AC004906 Genomic DNA. Translation: AAQ96893.1 . Sequence problems.
CH236953 Genomic DNA. Translation: EAL23962.1 . Sequence problems.
BC111719 mRNA. Translation: AAI11720.2 . Different initiation.
AF352576 mRNA. Translation: AAL34460.1 .
CCDSi CCDS5336.2.
RefSeqi NP_115791.3. NM_032415.5.
UniGenei Hs.648101.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4JUP X-ray 3.20 A/B 21-116 [» ]
4LWD X-ray 1.79 A 18-110 [» ]
ProteinModelPortali Q9BXL7.
SMRi Q9BXL7. Positions 21-110, 673-845.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 124073. 21 interactions.
DIPi DIP-41797N.
IntActi Q9BXL7. 7 interactions.
MINTi MINT-193901.
STRINGi 9606.ENSP00000380150.

PTM databases

PhosphoSitei Q9BXL7.

Polymorphism databases

DMDMi 172046231.

Proteomic databases

MaxQBi Q9BXL7.
PaxDbi Q9BXL7.
PRIDEi Q9BXL7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000396946 ; ENSP00000380150 ; ENSG00000198286 .
GeneIDi 84433.
KEGGi hsa:84433.
UCSCi uc003smv.3. human.

Organism-specific databases

CTDi 84433.
GeneCardsi GC07M002912.
H-InvDB HIX0033921.
HGNCi HGNC:16393. CARD11.
HPAi HPA052984.
MIMi 606445. phenotype.
607210. gene.
615206. phenotype.
neXtProti NX_Q9BXL7.
Orphaneti 300324. Persistent polyclonal B-cell lymphocytosis.
357237. Severe combined immunodeficiency due to CARD11 deficiency.
PharmGKBi PA26073.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG47732.
HOVERGENi HBG099790.
InParanoidi Q9BXL7.
KOi K07367.
OMAi EALPCLY.
OrthoDBi EOG747PH5.
PhylomeDBi Q9BXL7.
TreeFami TF351139.

Enzyme and pathway databases

Reactomei REACT_118656. Activation of NF-kappaB in B cells.
REACT_12555. Downstream TCR signaling.
REACT_163994. FCERI mediated NF-kB activation.
SignaLinki Q9BXL7.

Miscellaneous databases

ChiTaRSi CARD11. human.
GeneWikii CARD11.
GenomeRNAii 84433.
NextBioi 74170.
PROi Q9BXL7.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9BXL7.
Bgeei Q9BXL7.
CleanExi HS_CARD11.
Genevestigatori Q9BXL7.

Family and domain databases

Gene3Di 1.10.533.10. 1 hit.
2.30.42.10. 1 hit.
3.40.50.300. 2 hits.
InterProi IPR001315. CARD.
IPR011029. DEATH-like_dom.
IPR027417. P-loop_NTPase.
IPR001478. PDZ.
[Graphical view ]
Pfami PF00619. CARD. 1 hit.
[Graphical view ]
SMARTi SM00228. PDZ. 1 hit.
[Graphical view ]
SUPFAMi SSF47986. SSF47986. 1 hit.
SSF50156. SSF50156. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEi PS50209. CARD. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "CARD11 and CARD14 are novel caspase recruitment domain (CARD)/membrane-associated guanylate kinase (MAGUK) family members that interact with Bcl10 and activate NF-kappaB."
    Bertin J., Wang L., Guo Y., Jacobson M.D., Poyet J.-L., Srinivasula S.M., Merriam S., DiStefano P.S., Alnemri E.S.
    J. Biol. Chem. 276:11877-11882(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
  2. "The DNA sequence of human chromosome 7."
    Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
    , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
    Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "Human chromosome 7: DNA sequence and biology."
    Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S.
    , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C.
    Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. "Carma1, a CARD-containing binding partner of Bcl10, induces Bcl10 phosphorylation and NF-kappaB activation."
    Gaide O., Martinon F., Micheau O., Bonnet D., Thome M., Tschopp J.
    FEBS Lett. 496:121-127(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 8-1154.
  6. Erratum
    Gaide O., Martinon F., Micheau O., Bonnet D., Thome M., Tschopp J.
    FEBS Lett. 505:198-198(2001)
  7. Cited for: IDENTIFICATION IN A MEMBRANE RAFT COMPLEX, INTERACTION WITH DPP4, SUBCELLULAR LOCATION, IDENTIFICATION BY MASS SPECTROMETRY.
  8. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-466; SER-593 AND SER-925, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  10. "Deficiency of caspase recruitment domain family, member 11 (CARD11), causes profound combined immunodeficiency in human subjects."
    Stepensky P., Keller B., Buchta M., Kienzler A.K., Elpeleg O., Somech R., Cohen S., Shachar I., Miosge L.A., Schlesier M., Fuchs I., Enders A., Eibel H., Grimbacher B., Warnatz K.
    J. Allergy Clin. Immunol. 131:477-485(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: INVOLVEMENT IN IMD11.
  11. Cited for: VARIANTS PPBL SER-123 AND GLY-134, CHARACTERIZATION OF VARIANTS PPBL SER-123 AND GLY-134.

Entry informationi

Entry nameiCAR11_HUMAN
AccessioniPrimary (citable) accession number: Q9BXL7
Secondary accession number(s): A4D1Z7, Q2NKN7, Q548H3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 31, 2002
Last sequence update: February 26, 2008
Last modified: September 3, 2014
This is version 125 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Supposed to contain a SH3 domain which is not detected by PROSITE, Pfam or SMART.

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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