Q9BXL7 (CAR11_HUMAN) Reviewed, UniProtKB/Swiss-Prot
Last modified
May 1, 2013.
Version 111.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Caspase recruitment domain-containing protein 11 Alternative name(s): CARD-containing MAGUK protein 1 Short name=Carma 1 | ||||
| Gene names |
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| Organism | Homo sapiens (Human) [Reference proteome] | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo![]() |
Protein attributes
| Sequence length | 1154 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at protein level |
General annotation (Comments)
| Function | Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Activates NF-kappa-B via BCL10 and IKK. Stimulates the phosphorylation of BCL10. |
| Subunit structure | Found in a membrane raft complex, at least composed of BCL10, CARD11, DPP4 and IKBKB. CARD11 and BCL10 bind to each other by CARD-CARD interaction. Interacts (via PDZ domain) with DPP4 (via cytoplasmic tail). Ref.7 |
| Subcellular location | Cytoplasm. Membrane raft. Note: Colocalized with DPP4 in membrane rafts. Ref.7 |
| Tissue specificity | Detected in adult peripheral blood leukocytes, thymus, spleen and liver. Also found in promyelocytic leukemia HL-60 cells, chronic myelogenous leukemia K-562 cells, Burkitt's lymphoma Raji cells and colorectal adenocarcinoma SW480 cells. Not detected in HeLaS3, MOLT-4, A-549 and G431 cells. Ref.1 |
| Post-translational modification | Phosphorylation at Ser-559, Ser-644 and Ser-652 by PRKCB and PRKCQ leads to a shift from an inactive to an active form that activates the NF-kappa-B signaling By similarity. |
| Sequence similarities | Contains 1 CARD domain. Contains 1 guanylate kinase-like domain. Contains 1 PDZ (DHR) domain. |
| Caution | Supposed to contain a SH3 domain which is not detected by PROSITE, Pfam or SMART. |
| Sequence caution | The sequence AAG53402.1 differs from that shown. Reason: Erroneous initiation. The sequence AAI11720.2 differs from that shown. Reason: Erroneous initiation. The sequence AAQ96893.1 differs from that shown. Reason: Erroneous gene model prediction. The sequence EAL23962.1 differs from that shown. Reason: Erroneous gene model prediction. |
Ontologies
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 1154 | 1154 | Caspase recruitment domain-containing protein 11 | PRO_0000144086 | |||||
Regions | |||||||||
| Domain | 18 – 110 | 93 | CARD | ||||||
| Domain | 667 – 755 | 89 | PDZ | ||||||
| Domain | 973 – 1140 | 168 | Guanylate kinase-like | ||||||
| Coiled coil | 130 – 449 | 320 | Potential | ||||||
Amino acid modifications | |||||||||
| Modified residue | 466 | 1 | Phosphoserine Ref.8 | ||||||
| Modified residue | 559 | 1 | Phosphoserine; by PKC/PRKCB and PKC/PRKCQ By similarity | ||||||
| Modified residue | 593 | 1 | Phosphoserine Ref.8 | ||||||
| Modified residue | 644 | 1 | Phosphoserine; by PKC/PRKCB and PKC/PRKCQ By similarity | ||||||
| Modified residue | 652 | 1 | Phosphoserine; by PKC/PRKCB and PKC/PRKCQ By similarity | ||||||
| Modified residue | 925 | 1 | Phosphoserine Ref.8 | ||||||
Natural variations | |||||||||
| Natural variant | 670 | 1 | T → M. Corresponds to variant rs3735134 [ dbSNP | Ensembl ]. | VAR_028117 | |||||
| Natural variant | 694 | 1 | S → L. Corresponds to variant rs3735133 [ dbSNP | Ensembl ]. | VAR_028118 | |||||
Experimental info | |||||||||
| Sequence conflict | 815 | 1 | L → P in AAG53402. Ref.1 | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "CARD11 and CARD14 are novel caspase recruitment domain (CARD)/membrane-associated guanylate kinase (MAGUK) family members that interact with Bcl10 and activate NF-kappaB." Bertin J., Wang L., Guo Y., Jacobson M.D., Poyet J.-L., Srinivasula S.M., Merriam S., DiStefano P.S., Alnemri E.S. J. Biol. Chem. 276:11877-11882(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY. |
| [2] | "The DNA sequence of human chromosome 7." Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L. Wilson R.K.Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [3] | "Human chromosome 7: DNA sequence and biology." Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S. Tsui L.-C.Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [4] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. |
| [5] | "Carma1, a CARD-containing binding partner of Bcl10, induces Bcl10 phosphorylation and NF-kappaB activation." Gaide O., Martinon F., Micheau O., Bonnet D., Thome M., Tschopp J. FEBS Lett. 496:121-127(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 8-1154. |
| [6] | Erratum Gaide O., Martinon F., Micheau O., Bonnet D., Thome M., Tschopp J. FEBS Lett. 505:198-198(2001) |
| [7] | "Caveolin-1 triggers T-cell activation via CD26 in association with CARMA1." Ohnuma K., Uchiyama M., Yamochi T., Nishibashi K., Hosono O., Takahashi N., Kina S., Tanaka H., Lin X., Dang N.H., Morimoto C. J. Biol. Chem. 282:10117-10131(2007) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION IN A MEMBRANE RAFT COMPLEX, INTERACTION WITH DPP4, SUBCELLULAR LOCATION, IDENTIFICATION BY MASS SPECTROMETRY. |
| [8] | "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-466; SER-593 AND SER-925, MASS SPECTROMETRY. Tissue: Leukemic T-cell. |
| [9] | "Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AF322641 mRNA. Translation: AAG53402.1. Different initiation. AC004906 Genomic DNA. Translation: AAQ96893.1. Sequence problems. CH236953 Genomic DNA. Translation: EAL23962.1. Sequence problems. BC111719 mRNA. Translation: AAI11720.2. Different initiation. AF352576 mRNA. Translation: AAL34460.1. |
| IPI | IPI00869011. |
| RefSeq | NP_115791.3. NM_032415.4. |
| UniGene | Hs.648101. |
3D structure databases | |
| ProteinModelPortal | Q9BXL7. |
| ModBase | Search... |
Protein-protein interaction databases | |
| DIP | DIP-41797N. |
| MINT | MINT-193901. |
| STRING | 9606.ENSP00000380150. |
PTM databases | |
| PhosphoSite | Q9BXL7. |
Polymorphism databases | |
| DMDM | 172046231. |
Proteomic databases | |
| PaxDb | Q9BXL7. |
| PRIDE | Q9BXL7. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| Ensembl | ENST00000396946; ENSP00000380150; ENSG00000198286. |
| GeneID | 84433. |
| KEGG | hsa:84433. |
| UCSC | uc003smv.3. human. |
Organism-specific databases | |
| CTD | 84433. |
| GeneCards | GC07M002912. |
| H-InvDB | HIX0033921. |
| HGNC | HGNC:16393. CARD11. |
| HPA | HPA052984. |
| MIM | 607210. gene. |
| neXtProt | NX_Q9BXL7. |
| PharmGKB | PA26073. |
| GenAtlas | Search... |
Phylogenomic databases | |
| eggNOG | NOG47732. |
| HOVERGEN | HBG099790. |
| InParanoid | Q9BXL7. |
| KO | K07367. |
| OMA | AKNKHCL. |
| OrthoDB | EOG4MW85G. |
Enzyme and pathway databases | |
| Pathway_Interaction_DB | bcr_5pathway. BCR signaling pathway. tcrpathway. TCR signaling in naive CD4+ T cells. cd8tcrpathway. TCR signaling in naive CD8+ T cells. |
| Reactome | REACT_6900. Immune System. |
Gene expression databases | |
| ArrayExpress | Q9BXL7. |
| Bgee | Q9BXL7. |
| CleanEx | HS_CARD11. |
| Genevestigator | Q9BXL7. |
| GermOnline | ENSG00000198286. Homo sapiens. |
Family and domain databases | |
| Gene3D | 1.10.533.10. 1 hit. |
| InterPro | IPR001315. CARD. IPR011029. DEATH-like_dom. IPR001478. PDZ. [Graphical view] |
| Pfam | PF00619. CARD. 1 hit. [Graphical view] |
| SMART | SM00228. PDZ. 1 hit. [Graphical view] |
| SUPFAM | SSF47986. DEATH_like. 1 hit. SSF50156. PDZ. 1 hit. |
| PROSITE | PS50209. CARD. 1 hit. PS00856. GUANYLATE_KINASE_1. False negative. PS50052. GUANYLATE_KINASE_2. False negative. PS50106. PDZ. False negative. [Graphical view] |
| ProtoNet | Search... |
Other | |
| ChiTaRS | CARD11. human. |
| GenomeRNAi | 84433. |
| NextBio | 74170. |
| SOURCE | Search... |
Entry information
| Entry name | CAR11_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q9BXL7 Secondary accession number(s): A4D1Z7, Q2NKN7, Q548H3 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Chordata Protein Annotation Program | ||||||||
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | ||||||||
Relevant documents
| Human chromosome 7 Human chromosome 7: entries, gene names and cross-references to MIM |
| Human entries with polymorphisms or disease mutations List of human entries with polymorphisms or disease mutations |
| Human polymorphisms and disease mutations Index of human polymorphisms and disease mutations |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with
