Reviewed,
UniProtKB/Swiss-Prot Q9BXL7 (CAR11_HUMAN)
Last modified
May 5, 2009.
Version 71.
History...
Clusters with 100%,
90%,
50% identity |
Documents (5) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Caspase recruitment domain-containing protein 11 Alternative name(s): CARD-containing MAGUK protein 3 Carma 1 | ||||
| Gene names |
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| Organism | Homo sapiens (Human) | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 1154 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Activates NF-kappa-B via BCL10 and IKK. Stimulates the phosphorylation of BCL10. |
| Subunit structure | CARD11 and BCL10 bind to each other by CARD-CARD interaction. |
| Subcellular location | |
| Tissue specificity | Detected in adult peripheral blood leukocytes, thymus, spleen and liver. Also found in promyelocytic leukemia HL-60 cells, chronic myelogenous leukemia K562 cells, Burkitt's lymphoma Raji cells and colorectal adenocarcinoma SW480 cells. Not detected in HeLa S3, Molt-4, A549 and G431 cells. |
| Sequence similarities | Contains 1 CARD domain. Contains 1 guanylate kinase-like domain. Contains 1 PDZ (DHR) domain. |
| Caution | Supposed to contain a SH3 domain which is not detected by PROSITE, Pfam or SMART. |
| Sequence caution | The sequence AAQ96893.1 differs from that shown. Reason: Erroneous gene model prediction. The sequence EAL23962.1 differs from that shown. Reason: Erroneous gene model prediction. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Cytoplasm |
| Coding sequence diversity | Polymorphism |
| Domain | Coiled coil |
| Gene Ontology (GO) | |
| Biological process | positive regulation of NF-kappaB transcription factor activity Inferred from mutant phenotype. Source: UniProtKB positive regulation of cytokine productionInferred from mutant phenotype. Source: UniProtKB regulation of apoptosisInferred from electronic annotation. Source: InterPro |
| Cellular component | cytosol Inferred from Experiment. Source: Reactome membrane raftInferred from direct assay. Source: UniProtKB plasma membraneInferred from direct assay. Source: UniProtKB |
| Molecular function | CARD domain binding Ref.1 Inferred from physical interaction. Source: UniProtKB guanylate kinase activity Ref.1Non-traceable author statement. Source: UniProtKB |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 1154 | 1154 | Caspase recruitment domain-containing protein 11 | PRO_0000144086 | |||||
Regions | |||||||||
| Domain | 18 – 110 | 93 | CARD | ||||||
| Domain | 667 – 755 | 89 | PDZ | ||||||
| Domain | 973 – 1140 | 168 | Guanylate kinase-like | ||||||
| Coiled coil | 130 – 449 | 320 | Potential | ||||||
Natural variations | |||||||||
| Natural variant | 670 | 1 | T → M: dbSNP rs3735134. | VAR_028117 | |||||
| Natural variant | 694 | 1 | S → L: dbSNP rs3735133. | VAR_028118 | |||||
Experimental info | |||||||||
| Sequence conflict | 815 | 1 | L → P in AAG53402. Ref.1 | ||||||
Sequences
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References
Cross-references
Sequence databases | |
|---|---|
| AF322641 mRNA. Translation: AAG53402.1. Different initiation. AC004906 Genomic DNA. Translation: AAQ96893.1. Sequence problems. CH236953 Genomic DNA. Translation: EAL23962.1. Sequence problems. BC111719 mRNA. Translation: AAI11720.2. Different initiation. AF352576 mRNA. Translation: AAL34460.1. | |
| IPI | IPI00869011. |
| RefSeq | NP_115791.3. |
| UniGene | Hs.648101 |
3D structure databases | |
| ModBase | Search... |
PTM databases | |
| PhosphoSite | Q9BXL7. |
Proteomic databases | |
| PRIDE | Q9BXL7. |
Genome annotation databases | |
| Ensembl | ENSG00000198286. Homo sapiens. [Contig view] |
| GeneID | 84433. |
| KEGG | hsa:84433. |
Organism-specific databases | |
| GeneCards | GC07M002912. |
| H-InvDB | HIX0033921. |
| HGNC | HGNC:16393. CARD11. |
| MIM | 607210. gene. |
| PharmGKB | PA26073. |
| GenAtlas | Search... |
Phylogenomic databases | |
| HOVERGEN | Q9BXL7. |
Enzyme and pathway databases | |
| Pathway_Interaction_DB | bcr_5pathway. BCR signaling pathway. tcrpathway. TCR signaling in naive CD4+ T cells. cd8tcrpathway. TCR signaling in naive CD8+ T cells. |
| Reactome | REACT_6900. Signaling in Immune system. |
Gene expression databases | |
| ArrayExpress | Q9BXL7. |
| Bgee | Q9BXL7. |
| CleanEx | HS_CARD11. |
| GermOnline | ENSG00000198286. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR001315. CARD. IPR008144. Guanylate_kin. IPR001478. PDZ/DHR/GLGF. [Graphical view] |
| Pfam | PF00619. CARD. 1 hit. [Graphical view] |
| SMART | SM00228. PDZ. 1 hit. [Graphical view] |
| PROSITE | PS50209. CARD. 1 hit. PS00856. GUANYLATE_KINASE_1. False negative. PS50052. GUANYLATE_KINASE_2. False negative. PS50106. PDZ. False negative. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 74170. |
| SOURCE | Search... |
Entry information
| Entry name | CAR11_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q9BXL7 Secondary accession number(s): A4D1Z7, Q2NKN7, Q548H3 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| Human chromosome 7 Human chromosome 7: entries, gene names and cross-references to MIM |
| Human entries with polymorphisms or disease mutations List of human entries with polymorphisms or disease mutations |
| Human polymorphisms and disease mutations Index of human polymorphisms and disease mutations |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with


