Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q9BXL7

- CAR11_HUMAN

UniProt

Q9BXL7 - CAR11_HUMAN

Protein

Caspase recruitment domain-containing protein 11

Gene

CARD11

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 126 (01 Oct 2014)
      Sequence version 3 (26 Feb 2008)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Activates NF-kappa-B via BCL10 and IKK. Stimulates the phosphorylation of BCL10.

    GO - Molecular functioni

    1. CARD domain binding Source: UniProtKB
    2. guanylate kinase activity Source: UniProtKB
    3. protein binding Source: UniProtKB

    GO - Biological processi

    1. Fc-epsilon receptor signaling pathway Source: Reactome
    2. innate immune response Source: Reactome
    3. nucleotide phosphorylation Source: GOC
    4. positive regulation of B cell proliferation Source: Ensembl
    5. positive regulation of cytokine production Source: UniProtKB
    6. positive regulation of I-kappaB kinase/NF-kappaB signaling Source: Ensembl
    7. positive regulation of interleukin-2 biosynthetic process Source: Ensembl
    8. positive regulation of NF-kappaB transcription factor activity Source: UniProtKB
    9. positive regulation of T cell proliferation Source: Ensembl
    10. regulation of apoptotic process Source: InterPro
    11. regulation of B cell differentiation Source: Ensembl
    12. regulation of T cell differentiation Source: Ensembl
    13. T cell costimulation Source: UniProtKB
    14. T cell receptor signaling pathway Source: Reactome
    15. thymic T cell selection Source: Ensembl

    Enzyme and pathway databases

    ReactomeiREACT_118656. Activation of NF-kappaB in B cells.
    REACT_12555. Downstream TCR signaling.
    REACT_163994. FCERI mediated NF-kB activation.
    SignaLinkiQ9BXL7.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Caspase recruitment domain-containing protein 11
    Alternative name(s):
    CARD-containing MAGUK protein 1
    Short name:
    Carma 1
    Gene namesi
    Name:CARD11
    Synonyms:CARMA1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 7

    Organism-specific databases

    HGNCiHGNC:16393. CARD11.

    Subcellular locationi

    Cytoplasm 1 Publication. Membrane raft 1 Publication
    Note: Colocalized with DPP4 in membrane rafts.

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB
    2. cytosol Source: Reactome
    3. membrane raft Source: UniProtKB
    4. plasma membrane Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm, Membrane

    Pathology & Biotechi

    Involvement in diseasei

    Persistent polyclonal B-cell lymphocytosis (PPBL) [MIM:606445]: An autosomal dominant condition characterized by onset in infancy of splenomegaly and polyclonal expansion of B cells, resulting in peripheral lymphocytosis. Affected individuals also show mild immune dysfunction, including some defective antibody responses and T-cell anergy. There may be a predisposition to the development of B-cell malignancy.1 Publication
    Note: The disease is caused by mutations affecting the gene represented in this entry.
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti123 – 1231G → S in PPBL; results in protein aggregation and constitutive NFKB activation. 1 Publication
    VAR_069710
    Natural varianti134 – 1341E → G in PPBL; results in protein aggregation and constitutive NFKB activation. 1 Publication
    VAR_069711
    Immunodeficiency 11 (IMD11) [MIM:615206]: An autosomal recessive primary immunodeficiency characterized by normal numbers of T and B-lymphocytes, but defective intracellular signaling. There is a block in B-cell differentiation with increased numbers of transitional B-cells and hypogammaglobulinemia, as well as decreased numbers of regulatory T-cells and defects in T-cell function.1 Publication
    Note: The disease is caused by mutations affecting the gene represented in this entry.

    Keywords - Diseasei

    Disease mutation

    Organism-specific databases

    MIMi606445. phenotype.
    615206. phenotype.
    Orphaneti300324. Persistent polyclonal B-cell lymphocytosis.
    357237. Severe combined immunodeficiency due to CARD11 deficiency.
    PharmGKBiPA26073.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 11541154Caspase recruitment domain-containing protein 11PRO_0000144086Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei466 – 4661Phosphoserine1 Publication
    Modified residuei559 – 5591Phosphoserine; by PKC/PRKCB and PKC/PRKCQBy similarity
    Modified residuei593 – 5931Phosphoserine1 Publication
    Modified residuei644 – 6441Phosphoserine; by PKC/PRKCB and PKC/PRKCQBy similarity
    Modified residuei652 – 6521Phosphoserine; by PKC/PRKCB and PKC/PRKCQBy similarity
    Modified residuei925 – 9251Phosphoserine1 Publication

    Post-translational modificationi

    Phosphorylation at Ser-559, Ser-644 and Ser-652 by PRKCB and PRKCQ leads to a shift from an inactive to an active form that activates the NF-kappa-B signaling.By similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ9BXL7.
    PaxDbiQ9BXL7.
    PRIDEiQ9BXL7.

    PTM databases

    PhosphoSiteiQ9BXL7.

    Expressioni

    Tissue specificityi

    Detected in adult peripheral blood leukocytes, thymus, spleen and liver. Also found in promyelocytic leukemia HL-60 cells, chronic myelogenous leukemia K-562 cells, Burkitt's lymphoma Raji cells and colorectal adenocarcinoma SW480 cells. Not detected in HeLaS3, MOLT-4, A-549 and G431 cells.1 Publication

    Gene expression databases

    ArrayExpressiQ9BXL7.
    BgeeiQ9BXL7.
    CleanExiHS_CARD11.
    GenevestigatoriQ9BXL7.

    Organism-specific databases

    HPAiHPA052984.

    Interactioni

    Subunit structurei

    Found in a membrane raft complex, at least composed of BCL10, CARD11, DPP4 and IKBKB. CARD11 and BCL10 bind to each other by CARD-CARD interaction. Interacts (via PDZ domain) with DPP4 (via cytoplasmic tail).1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    BCL10O959994EBI-7006141,EBI-958922

    Protein-protein interaction databases

    BioGridi124073. 21 interactions.
    DIPiDIP-41797N.
    IntActiQ9BXL7. 8 interactions.
    MINTiMINT-193901.
    STRINGi9606.ENSP00000380150.

    Structurei

    Secondary structure

    1
    1154
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi24 – 274
    Helixi30 – 367
    Helixi39 – 4810
    Helixi54 – 618
    Turni70 – 734
    Helixi74 – 807
    Helixi84 – 9815
    Helixi100 – 1078

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4JUPX-ray3.20A/B21-116[»]
    4LWDX-ray1.79A18-110[»]
    ProteinModelPortaliQ9BXL7.
    SMRiQ9BXL7. Positions 21-110, 673-845.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini18 – 11093CARDPROSITE-ProRule annotationAdd
    BLAST
    Domaini667 – 75589PDZAdd
    BLAST
    Domaini973 – 1140168Guanylate kinase-likeAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili130 – 449320Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Contains 1 CARD domain.PROSITE-ProRule annotation
    Contains 1 guanylate kinase-like domain.Curated
    Contains 1 PDZ (DHR) domain.Curated

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG47732.
    HOVERGENiHBG099790.
    InParanoidiQ9BXL7.
    KOiK07367.
    OMAiEALPCLY.
    OrthoDBiEOG747PH5.
    PhylomeDBiQ9BXL7.
    TreeFamiTF351139.

    Family and domain databases

    Gene3Di1.10.533.10. 1 hit.
    2.30.42.10. 1 hit.
    3.40.50.300. 2 hits.
    InterProiIPR001315. CARD.
    IPR011029. DEATH-like_dom.
    IPR027417. P-loop_NTPase.
    IPR001478. PDZ.
    [Graphical view]
    PfamiPF00619. CARD. 1 hit.
    [Graphical view]
    SMARTiSM00228. PDZ. 1 hit.
    [Graphical view]
    SUPFAMiSSF47986. SSF47986. 1 hit.
    SSF50156. SSF50156. 1 hit.
    SSF52540. SSF52540. 1 hit.
    PROSITEiPS50209. CARD. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9BXL7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPGGGPEMDD YMETLKDEED ALWENVECNR HMLSRYINPA KLTPYLRQCK     50
    VIDEQDEDEV LNAPMLPSKI NRAGRLLDIL HTKGQRGYVV FLESLEFYYP 100
    ELYKLVTGKE PTRRFSTIVV EEGHEGLTHF LMNEVIKLQQ QMKAKDLQRC 150
    ELLARLRQLE DEKKQMTLTR VELLTFQERY YKMKEERDSY NDELVKVKDD 200
    NYNLAMRYAQ LSEEKNMAVM RSRDLQLEID QLKHRLNKME EECKLERNQS 250
    LKLKNDIENR PKKEQVLELE RENEMLKTKN QELQSIIQAG KRSLPDSDKA 300
    ILDILEHDRK EALEDRQELV NRIYNLQEEA RQAEELRDKY LEEKEDLELK 350
    CSTLGKDCEM YKHRMNTVML QLEEVERERD QAFHSRDEAQ TQYSQCLIEK 400
    DKYRKQIREL EEKNDEMRIE MVRREACIVN LESKLRRLSK DSNNLDQSLP 450
    RNLPVTIISQ DFGDASPRTN GQEADDSSTS EESPEDSKYF LPYHPPQRRM 500
    NLKGIQLQRA KSPISLKRTS DFQAKGHEEE GTDASPSSCG SLPITNSFTK 550
    MQPPRSRSSI MSITAEPPGN DSIVRRYKED APHRSTVEED NDSGGFDALD 600
    LDDDSHERYS FGPSSIHSSS SSHQSEGLDA YDLEQVNLMF RKFSLERPFR 650
    PSVTSVGHVR GPGPSVQHTT LNGDSLTSQL TLLGGNARGS FVHSVKPGSL 700
    AEKAGLREGH QLLLLEGCIR GERQSVPLDT CTKEEAHWTI QRCSGPVTLH 750
    YKVNHEGYRK LVKDMEDGLI TSGDSFYIRL NLNISSQLDA CTMSLKCDDV 800
    VHVRDTMYQD RHEWLCARVD PFTDHDLDMG TIPSYSRAQQ LLLVKLQRLM 850
    HRGSREEVDG THHTLRALRN TLQPEEALST SDPRVSPRLS RASFLFGQLL 900
    QFVSRSENKY KRMNSNERVR IISGSPLGSL ARSSLDATKL LTEKQEELDP 950
    ESELGKNLSL IPYSLVRAFY CERRRPVLFT PTVLAKTLVQ RLLNSGGAME 1000
    FTICKSDIVT RDEFLRRQKT ETIIYSREKN PNAFECIAPA NIEAVAAKNK 1050
    HCLLEAGIGC TRDLIKSNIY PIVLFIRVCE KNIKRFRKLL PRPETEEEFL 1100
    RVCRLKEKEL EALPCLYATV EPDMWGSVEE LLRVVKDKIG EEQRKTIWVD 1150
    EDQL 1154
    Length:1,154
    Mass (Da):133,284
    Last modified:February 26, 2008 - v3
    Checksum:i2F3512D903795D18
    GO

    Sequence cautioni

    The sequence AAG53402.1 differs from that shown. Reason: Erroneous initiation.
    The sequence AAI11720.2 differs from that shown. Reason: Erroneous initiation.
    The sequence AAQ96893.1 differs from that shown. Reason: Erroneous gene model prediction.
    The sequence EAL23962.1 differs from that shown. Reason: Erroneous gene model prediction.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti815 – 8151L → P in AAG53402. (PubMed:11278692)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti123 – 1231G → S in PPBL; results in protein aggregation and constitutive NFKB activation. 1 Publication
    VAR_069710
    Natural varianti134 – 1341E → G in PPBL; results in protein aggregation and constitutive NFKB activation. 1 Publication
    VAR_069711
    Natural varianti670 – 6701T → M.
    Corresponds to variant rs3735134 [ dbSNP | Ensembl ].
    VAR_028117
    Natural varianti694 – 6941S → L.
    Corresponds to variant rs3735133 [ dbSNP | Ensembl ].
    VAR_028118

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF322641 mRNA. Translation: AAG53402.1. Different initiation.
    AC004906 Genomic DNA. Translation: AAQ96893.1. Sequence problems.
    CH236953 Genomic DNA. Translation: EAL23962.1. Sequence problems.
    BC111719 mRNA. Translation: AAI11720.2. Different initiation.
    AF352576 mRNA. Translation: AAL34460.1.
    CCDSiCCDS5336.2.
    RefSeqiNP_115791.3. NM_032415.5.
    UniGeneiHs.648101.

    Genome annotation databases

    EnsembliENST00000396946; ENSP00000380150; ENSG00000198286.
    GeneIDi84433.
    KEGGihsa:84433.
    UCSCiuc003smv.3. human.

    Polymorphism databases

    DMDMi172046231.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF322641 mRNA. Translation: AAG53402.1 . Different initiation.
    AC004906 Genomic DNA. Translation: AAQ96893.1 . Sequence problems.
    CH236953 Genomic DNA. Translation: EAL23962.1 . Sequence problems.
    BC111719 mRNA. Translation: AAI11720.2 . Different initiation.
    AF352576 mRNA. Translation: AAL34460.1 .
    CCDSi CCDS5336.2.
    RefSeqi NP_115791.3. NM_032415.5.
    UniGenei Hs.648101.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4JUP X-ray 3.20 A/B 21-116 [» ]
    4LWD X-ray 1.79 A 18-110 [» ]
    ProteinModelPortali Q9BXL7.
    SMRi Q9BXL7. Positions 21-110, 673-845.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 124073. 21 interactions.
    DIPi DIP-41797N.
    IntActi Q9BXL7. 8 interactions.
    MINTi MINT-193901.
    STRINGi 9606.ENSP00000380150.

    PTM databases

    PhosphoSitei Q9BXL7.

    Polymorphism databases

    DMDMi 172046231.

    Proteomic databases

    MaxQBi Q9BXL7.
    PaxDbi Q9BXL7.
    PRIDEi Q9BXL7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000396946 ; ENSP00000380150 ; ENSG00000198286 .
    GeneIDi 84433.
    KEGGi hsa:84433.
    UCSCi uc003smv.3. human.

    Organism-specific databases

    CTDi 84433.
    GeneCardsi GC07M002912.
    H-InvDB HIX0033921.
    HGNCi HGNC:16393. CARD11.
    HPAi HPA052984.
    MIMi 606445. phenotype.
    607210. gene.
    615206. phenotype.
    neXtProti NX_Q9BXL7.
    Orphaneti 300324. Persistent polyclonal B-cell lymphocytosis.
    357237. Severe combined immunodeficiency due to CARD11 deficiency.
    PharmGKBi PA26073.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG47732.
    HOVERGENi HBG099790.
    InParanoidi Q9BXL7.
    KOi K07367.
    OMAi EALPCLY.
    OrthoDBi EOG747PH5.
    PhylomeDBi Q9BXL7.
    TreeFami TF351139.

    Enzyme and pathway databases

    Reactomei REACT_118656. Activation of NF-kappaB in B cells.
    REACT_12555. Downstream TCR signaling.
    REACT_163994. FCERI mediated NF-kB activation.
    SignaLinki Q9BXL7.

    Miscellaneous databases

    ChiTaRSi CARD11. human.
    GeneWikii CARD11.
    GenomeRNAii 84433.
    NextBioi 74170.
    PROi Q9BXL7.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9BXL7.
    Bgeei Q9BXL7.
    CleanExi HS_CARD11.
    Genevestigatori Q9BXL7.

    Family and domain databases

    Gene3Di 1.10.533.10. 1 hit.
    2.30.42.10. 1 hit.
    3.40.50.300. 2 hits.
    InterProi IPR001315. CARD.
    IPR011029. DEATH-like_dom.
    IPR027417. P-loop_NTPase.
    IPR001478. PDZ.
    [Graphical view ]
    Pfami PF00619. CARD. 1 hit.
    [Graphical view ]
    SMARTi SM00228. PDZ. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47986. SSF47986. 1 hit.
    SSF50156. SSF50156. 1 hit.
    SSF52540. SSF52540. 1 hit.
    PROSITEi PS50209. CARD. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "CARD11 and CARD14 are novel caspase recruitment domain (CARD)/membrane-associated guanylate kinase (MAGUK) family members that interact with Bcl10 and activate NF-kappaB."
      Bertin J., Wang L., Guo Y., Jacobson M.D., Poyet J.-L., Srinivasula S.M., Merriam S., DiStefano P.S., Alnemri E.S.
      J. Biol. Chem. 276:11877-11882(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    2. "The DNA sequence of human chromosome 7."
      Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
      , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
      Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "Human chromosome 7: DNA sequence and biology."
      Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S.
      , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C.
      Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    5. "Carma1, a CARD-containing binding partner of Bcl10, induces Bcl10 phosphorylation and NF-kappaB activation."
      Gaide O., Martinon F., Micheau O., Bonnet D., Thome M., Tschopp J.
      FEBS Lett. 496:121-127(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 8-1154.
    6. Erratum
      Gaide O., Martinon F., Micheau O., Bonnet D., Thome M., Tschopp J.
      FEBS Lett. 505:198-198(2001)
    7. Cited for: IDENTIFICATION IN A MEMBRANE RAFT COMPLEX, INTERACTION WITH DPP4, SUBCELLULAR LOCATION, IDENTIFICATION BY MASS SPECTROMETRY.
    8. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-466; SER-593 AND SER-925, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    10. "Deficiency of caspase recruitment domain family, member 11 (CARD11), causes profound combined immunodeficiency in human subjects."
      Stepensky P., Keller B., Buchta M., Kienzler A.K., Elpeleg O., Somech R., Cohen S., Shachar I., Miosge L.A., Schlesier M., Fuchs I., Enders A., Eibel H., Grimbacher B., Warnatz K.
      J. Allergy Clin. Immunol. 131:477-485(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: INVOLVEMENT IN IMD11.
    11. Cited for: VARIANTS PPBL SER-123 AND GLY-134, CHARACTERIZATION OF VARIANTS PPBL SER-123 AND GLY-134.

    Entry informationi

    Entry nameiCAR11_HUMAN
    AccessioniPrimary (citable) accession number: Q9BXL7
    Secondary accession number(s): A4D1Z7, Q2NKN7, Q548H3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 31, 2002
    Last sequence update: February 26, 2008
    Last modified: October 1, 2014
    This is version 126 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Caution

    Supposed to contain a SH3 domain which is not detected by PROSITE, Pfam or SMART.Curated

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 7
      Human chromosome 7: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3