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Q9BXL6

- CAR14_HUMAN

UniProt

Q9BXL6 - CAR14_HUMAN

Protein

Caspase recruitment domain-containing protein 14

Gene

CARD14

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 118 (01 Oct 2014)
      Sequence version 2 (18 May 2010)
      Previous versions | rss
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    Functioni

    Plays a role in signaling mediated by TRAF2, TRAF3 and TRAF6 and protects cells against apoptosis. Activates NF-kappa-B via BCL10 and IKK. Stimulates the phosphorylation of BCL10.1 Publication

    GO - Molecular functioni

    1. CARD domain binding Source: UniProtKB

    GO - Biological processi

    1. activation of NF-kappaB-inducing kinase activity Source: UniProtKB
    2. apoptotic process Source: UniProtKB-KW
    3. negative regulation of apoptotic process Source: UniProtKB
    4. positive regulation of NF-kappaB transcription factor activity Source: UniProtKB
    5. positive regulation of protein phosphorylation Source: UniProtKB
    6. tumor necrosis factor-mediated signaling pathway Source: UniProtKB

    Keywords - Biological processi

    Apoptosis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Caspase recruitment domain-containing protein 14
    Alternative name(s):
    CARD-containing MAGUK protein 2
    Short name:
    Carma 2
    Gene namesi
    Name:CARD14
    Synonyms:CARMA2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 17

    Organism-specific databases

    HGNCiHGNC:16446. CARD14.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB
    2. plasma membrane Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm

    Pathology & Biotechi

    Involvement in diseasei

    Psoriasis 2 (PSORS2) [MIM:602723]: A common, chronic inflammatory disease of the skin with multifactorial etiology. It is characterized by red, scaly plaques usually found on the scalp, elbows and knees. These lesions are caused by abnormal keratinocyte proliferation and infiltration of inflammatory cells into the dermis and epidermis.2 Publications
    Note: Disease susceptibility is associated with variations affecting the gene represented in this entry.
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti117 – 1171G → S in PSORS2; may result in altered splicing of exon 3; results in increased NF-kappa-B activation. 2 Publications
    Corresponds to variant rs281875215 [ dbSNP | Ensembl ].
    VAR_068224
    Natural varianti138 – 1381E → A in PSORS2; results in increased NF-kappa-B activation. 2 Publications
    Corresponds to variant rs281875214 [ dbSNP | Ensembl ].
    VAR_068225
    Natural varianti142 – 1421E → G in PSORS2; results in increased NF-kappa-B activation. 1 Publication
    Corresponds to variant rs281875213 [ dbSNP | Ensembl ].
    VAR_068226
    Natural varianti142 – 1421E → K in PSORS2; results in increased NF-kappa-B activation. 1 Publication
    Corresponds to variant rs281875212 [ dbSNP | Ensembl ].
    VAR_068227
    Pityriasis rubra pilaris (PRP) [MIM:173200]: A rare, papulosquamous skin disease characterized by the appearance of keratotic follicular papules, well-demarcated salmon-colored erythematous plaques covered with fine powdery scales interspersed with distinct islands of uninvolved skin, and palmoplantar keratoderma. Most cases are sporadic. The rare familial cases show autosomal dominant inheritance with incomplete penetrance and variable expression. Familial PRP usually presents at birth or appears during the first years of life and runs a chronic course. It is characterized by prominent follicular hyperkeratosis, diffuse palmoplantar keratoderma, and erythema.1 Publication
    Note: The disease is caused by mutations affecting the gene represented in this entry.
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti138 – 1381Missing in PRP. 1 Publication
    VAR_068819
    Natural varianti156 – 1561L → P in PRP. 1 Publication
    VAR_068820

    Keywords - Diseasei

    Disease mutation

    Organism-specific databases

    MIMi173200. phenotype.
    602723. phenotype.
    Orphaneti2897. Pityriasis rubra pilaris.
    PharmGKBiPA134959119.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 10041004Caspase recruitment domain-containing protein 14PRO_0000144088Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei544 – 5441Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ9BXL6.
    PaxDbiQ9BXL6.
    PRIDEiQ9BXL6.

    PTM databases

    PhosphoSiteiQ9BXL6.

    Expressioni

    Tissue specificityi

    Isoform 1 is detected in placenta and epidermal keratinocytes. Isoform 2 is detected in leukocytes and fetal brain.1 Publication

    Gene expression databases

    ArrayExpressiQ9BXL6.
    BgeeiQ9BXL6.
    CleanExiHS_CARD14.
    GenevestigatoriQ9BXL6.

    Organism-specific databases

    HPAiHPA022533.
    HPA023388.

    Interactioni

    Subunit structurei

    Interacts with BCL10 by CARD-CARD interaction. Interacts with TRAF2, TRAF3 and TRAF6.1 Publication

    Protein-protein interaction databases

    BioGridi122540. 3 interactions.
    IntActiQ9BXL6. 1 interaction.
    MINTiMINT-193865.
    STRINGi9606.ENSP00000344549.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9BXL6.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini15 – 10793CARDPROSITE-ProRule annotationAdd
    BLAST
    Domaini568 – 65891PDZPROSITE-ProRule annotationAdd
    BLAST
    Domaini807 – 990184Guanylate kinase-likePROSITE-ProRule annotationAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili128 – 409282Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Contains 1 CARD domain.PROSITE-ProRule annotation
    Contains 1 guanylate kinase-like domain.PROSITE-ProRule annotation
    Contains 1 PDZ (DHR) domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG314915.
    HOGENOMiHOG000049174.
    HOVERGENiHBG106927.
    InParanoidiQ9BXL6.
    OMAiMEKNTHA.
    OrthoDBiEOG747PH5.
    PhylomeDBiQ9BXL6.
    TreeFamiTF315606.

    Family and domain databases

    Gene3Di1.10.533.10. 1 hit.
    2.30.42.10. 1 hit.
    3.40.50.300. 1 hit.
    InterProiIPR001315. CARD.
    IPR011029. DEATH-like_dom.
    IPR008145. GK/Ca_channel_bsu.
    IPR008144. Guanylate_kin-like.
    IPR027417. P-loop_NTPase.
    IPR001478. PDZ.
    [Graphical view]
    PfamiPF00619. CARD. 1 hit.
    [Graphical view]
    SMARTiSM00072. GuKc. 1 hit.
    SM00228. PDZ. 1 hit.
    [Graphical view]
    SUPFAMiSSF47986. SSF47986. 1 hit.
    SSF50156. SSF50156. 1 hit.
    SSF52540. SSF52540. 1 hit.
    PROSITEiPS50209. CARD. 1 hit.
    PS50052. GUANYLATE_KINASE_2. 1 hit.
    PS50106. PDZ. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9BXL6-1) [UniParc]FASTAAdd to Basket

    Also known as: CARMA2fl

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MGELCRRDSA LTALDEETLW EMMESHRHRI VRCICPSRLT PYLRQAKVLC     50
    QLDEEEVLHS PRLTNSAMRA GHLLDLLKTR GKNGAIAFLE SLKFHNPDVY 100
    TLVTGLQPDV DFSNFSGLME TSKLTECLAG AIGSLQEELN QEKGQKEVLL 150
    RRCQQLQEHL GLAETRAEGL HQLEADHSRM KREVSAHFHE VLRLKDEMLS 200
    LSLHYSNALQ EKELAASRCR SLQEELYLLK QELQRANMVS SCELELQEQS 250
    LRTASDQESG DEELNRLKEE NEKLRSLTFS LAEKDILEQS LDEARGSRQE 300
    LVERIHSLRE RAVAAERQRE QYWEEKEQTL LQFQKSKMAC QLYREKVNAL 350
    QAQVCELQKE RDQAYSARDS AQREISQSLV EKDSLRRQVF ELTDQVCELR 400
    TQLRQLQAEP PGVLKQEART REPCPREKQR LVRMHAICPR DDSDCSLVSS 450
    TESQLLSDLS ATSSRELVDS FRSSSPAPPS QQSLYKRVAE DFGEEPWSFS 500
    SCLEIPEGDP GALPGAKAGD PHLDYELLDT ADLPQLESSL QPVSPGRLDV 550
    SESGVLMRRR PARRILSQVT MLAFQGDALL EQISVIGGNL TGIFIHRVTP 600
    GSAADQMALR PGTQIVMVDY EASEPLFKAV LEDTTLEEAV GLLRRVDGFC 650
    CLSVKVNTDG YKRLLQDLEA KVATSGDSFY IRVNLAMEGR AKGELQVHCN 700
    EVLHVTDTMF QGCGCWHAHR VNSYTMKDTA AHGTIPNYSR AQQQLIALIQ 750
    DMTQQCTVTR KPSSGGPQKL VRIVSMDKAK ASPLRLSFDR GQLDPSRMEG 800
    SSTCFWAESC LTLVPYTLVR PHRPARPRPV LLVPRAVGKI LSEKLCLLQG 850
    FKKCLAEYLS QEEYEAWSQR GDIIQEGEVS GGRCWVTRHA VESLMEKNTH 900
    ALLDVQLDSV CTLHRMDIFP IVIHVSVNEK MAKKLKKGLQ RLGTSEEQLL 950
    EAARQEEGDL DRAPCLYSSL APDGWSDLDG LLSCVRQAIA DEQKKVVWTE 1000
    QSPR 1004
    Length:1,004
    Mass (Da):113,270
    Last modified:May 18, 2010 - v2
    Checksum:i761CBAC219956076
    GO
    Isoform 2 (identifier: Q9BXL6-2) [UniParc]FASTAAdd to Basket

    Also known as: Short, CARMA2sh

    The sequence of this isoform differs from the canonical sequence as follows:
         741-1004: Missing.

    Show »
    Length:740
    Mass (Da):83,679
    Checksum:i90FCA1B1C2DB28D1
    GO
    Isoform 3 (identifier: Q9BXL6-3) [UniParc]FASTAAdd to Basket

    Also known as: Cardless, CARMA2cl

    The sequence of this isoform differs from the canonical sequence as follows:
         1-237: Missing.
         619-671: DYEASEPLFK...KRLLQDLEAK → SRARPLLSPG...WADVKRSAHL
         672-1004: Missing.

    Show »
    Length:434
    Mass (Da):48,505
    Checksum:iD351699781B6D6EB
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti38 – 381R → C.1 Publication
    Corresponds to variant rs281875217 [ dbSNP | Ensembl ].
    VAR_068222
    Natural varianti62 – 621R → Q.1 Publication
    Corresponds to variant rs115582620 [ dbSNP | Ensembl ].
    VAR_068223
    Natural varianti117 – 1171G → S in PSORS2; may result in altered splicing of exon 3; results in increased NF-kappa-B activation. 2 Publications
    Corresponds to variant rs281875215 [ dbSNP | Ensembl ].
    VAR_068224
    Natural varianti138 – 1381E → A in PSORS2; results in increased NF-kappa-B activation. 2 Publications
    Corresponds to variant rs281875214 [ dbSNP | Ensembl ].
    VAR_068225
    Natural varianti138 – 1381Missing in PRP. 1 Publication
    VAR_068819
    Natural varianti142 – 1421E → G in PSORS2; results in increased NF-kappa-B activation. 1 Publication
    Corresponds to variant rs281875213 [ dbSNP | Ensembl ].
    VAR_068226
    Natural varianti142 – 1421E → K in PSORS2; results in increased NF-kappa-B activation. 1 Publication
    Corresponds to variant rs281875212 [ dbSNP | Ensembl ].
    VAR_068227
    Natural varianti150 – 1501L → R.1 Publication
    Corresponds to variant rs146214639 [ dbSNP | Ensembl ].
    VAR_068228
    Natural varianti156 – 1561L → P in PRP. 1 Publication
    VAR_068820
    Natural varianti171 – 1711H → N May be associated with susceptibility to psoriasis. 1 Publication
    Corresponds to variant rs281875216 [ dbSNP | Ensembl ].
    VAR_068229
    Natural varianti176 – 1761D → H.1 Publication
    Corresponds to variant rs144475004 [ dbSNP | Ensembl ].
    VAR_068230
    Natural varianti179 – 1791R → H.1 Publication
    Corresponds to variant rs199517469 [ dbSNP | Ensembl ].
    VAR_068231
    Natural varianti191 – 1911V → L.1 Publication
    Corresponds to variant rs281875218 [ dbSNP | Ensembl ].
    VAR_068232
    Natural varianti200 – 2001S → N.1 Publication
    Corresponds to variant rs114688446 [ dbSNP | Ensembl ].
    VAR_068233
    Natural varianti285 – 2851D → G May be associated with susceptibility to psoriasis. 1 Publication
    Corresponds to variant rs281875219 [ dbSNP | Ensembl ].
    VAR_068234
    Natural varianti547 – 5471R → S.
    Corresponds to variant rs2066964 [ dbSNP | Ensembl ].
    VAR_024401
    Natural varianti585 – 5851V → I.
    Corresponds to variant rs34367357 [ dbSNP | Ensembl ].
    VAR_048608
    Natural varianti593 – 5931I → N.1 Publication
    Corresponds to variant rs281875220 [ dbSNP | Ensembl ].
    VAR_068235
    Natural varianti682 – 6821R → W.1 Publication
    Corresponds to variant rs117918077 [ dbSNP | Ensembl ].
    VAR_068236
    Natural varianti714 – 7141G → S.1 Publication
    Corresponds to variant rs151150961 [ dbSNP | Ensembl ].
    VAR_068237
    Natural varianti820 – 8201R → W.2 Publications
    Corresponds to variant rs11652075 [ dbSNP | Ensembl ].
    VAR_059196
    Natural varianti883 – 8831R → H.
    Corresponds to variant rs2289541 [ dbSNP | Ensembl ].
    VAR_022043
    Natural varianti962 – 9621R → Q.
    Corresponds to variant rs34850974 [ dbSNP | Ensembl ].
    VAR_061080
    Natural varianti973 – 9731D → E.1 Publication
    Corresponds to variant rs144285237 [ dbSNP | Ensembl ].
    VAR_068238

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 237237Missing in isoform 3. 2 PublicationsVSP_047400Add
    BLAST
    Alternative sequencei619 – 67153DYEAS…DLEAK → SRARPLLSPGLLMGTVAAGG VTQADFTSPRRCRSTLGWAS ALSWADVKRSAHL in isoform 3. 2 PublicationsVSP_047401Add
    BLAST
    Alternative sequencei672 – 1004333Missing in isoform 3. 2 PublicationsVSP_047402Add
    BLAST
    Alternative sequencei741 – 1004264Missing in isoform 2. 2 PublicationsVSP_047403Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF322642 mRNA. Translation: AAG53403.1.
    AY032927 mRNA. Translation: AAK54453.1.
    EU652409 mRNA. Translation: ACF49506.1.
    AC087741 Genomic DNA. No translation available.
    BC018142 mRNA. Translation: AAH18142.1.
    BC001326 mRNA. Translation: AAH01326.1.
    CCDSiCCDS11768.1. [Q9BXL6-1]
    CCDS58605.1. [Q9BXL6-2]
    RefSeqiNP_001244899.1. NM_001257970.1. [Q9BXL6-2]
    NP_077015.2. NM_024110.4. [Q9BXL6-1]
    NP_438170.1. NM_052819.2. [Q9BXL6-3]
    UniGeneiHs.675480.
    Hs.696253.
    Hs.735899.

    Genome annotation databases

    EnsembliENST00000344227; ENSP00000344549; ENSG00000141527. [Q9BXL6-1]
    ENST00000570421; ENSP00000461806; ENSG00000141527. [Q9BXL6-2]
    ENST00000573882; ENSP00000458715; ENSG00000141527. [Q9BXL6-1]
    GeneIDi79092.
    KEGGihsa:79092.
    UCSCiuc002jxv.3. human. [Q9BXL6-1]
    uc002jxx.3. human.

    Polymorphism databases

    DMDMi296434421.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Web resourcesi

    Caspase recruitment domain family, member 14 (CARD14)

    Leiden Open Variation Database (LOVD)

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF322642 mRNA. Translation: AAG53403.1 .
    AY032927 mRNA. Translation: AAK54453.1 .
    EU652409 mRNA. Translation: ACF49506.1 .
    AC087741 Genomic DNA. No translation available.
    BC018142 mRNA. Translation: AAH18142.1 .
    BC001326 mRNA. Translation: AAH01326.1 .
    CCDSi CCDS11768.1. [Q9BXL6-1 ]
    CCDS58605.1. [Q9BXL6-2 ]
    RefSeqi NP_001244899.1. NM_001257970.1. [Q9BXL6-2 ]
    NP_077015.2. NM_024110.4. [Q9BXL6-1 ]
    NP_438170.1. NM_052819.2. [Q9BXL6-3 ]
    UniGenei Hs.675480.
    Hs.696253.
    Hs.735899.

    3D structure databases

    ProteinModelPortali Q9BXL6.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 122540. 3 interactions.
    IntActi Q9BXL6. 1 interaction.
    MINTi MINT-193865.
    STRINGi 9606.ENSP00000344549.

    PTM databases

    PhosphoSitei Q9BXL6.

    Polymorphism databases

    DMDMi 296434421.

    Proteomic databases

    MaxQBi Q9BXL6.
    PaxDbi Q9BXL6.
    PRIDEi Q9BXL6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000344227 ; ENSP00000344549 ; ENSG00000141527 . [Q9BXL6-1 ]
    ENST00000570421 ; ENSP00000461806 ; ENSG00000141527 . [Q9BXL6-2 ]
    ENST00000573882 ; ENSP00000458715 ; ENSG00000141527 . [Q9BXL6-1 ]
    GeneIDi 79092.
    KEGGi hsa:79092.
    UCSCi uc002jxv.3. human. [Q9BXL6-1 ]
    uc002jxx.3. human.

    Organism-specific databases

    CTDi 79092.
    GeneCardsi GC17P078152.
    H-InvDB HIX0173685.
    HGNCi HGNC:16446. CARD14.
    HPAi HPA022533.
    HPA023388.
    MIMi 173200. phenotype.
    602723. phenotype.
    607211. gene.
    neXtProti NX_Q9BXL6.
    Orphaneti 2897. Pityriasis rubra pilaris.
    PharmGKBi PA134959119.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG314915.
    HOGENOMi HOG000049174.
    HOVERGENi HBG106927.
    InParanoidi Q9BXL6.
    OMAi MEKNTHA.
    OrthoDBi EOG747PH5.
    PhylomeDBi Q9BXL6.
    TreeFami TF315606.

    Miscellaneous databases

    ChiTaRSi CARD14. human.
    GeneWikii CARD14.
    GenomeRNAii 79092.
    NextBioi 67933.
    PROi Q9BXL6.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9BXL6.
    Bgeei Q9BXL6.
    CleanExi HS_CARD14.
    Genevestigatori Q9BXL6.

    Family and domain databases

    Gene3Di 1.10.533.10. 1 hit.
    2.30.42.10. 1 hit.
    3.40.50.300. 1 hit.
    InterProi IPR001315. CARD.
    IPR011029. DEATH-like_dom.
    IPR008145. GK/Ca_channel_bsu.
    IPR008144. Guanylate_kin-like.
    IPR027417. P-loop_NTPase.
    IPR001478. PDZ.
    [Graphical view ]
    Pfami PF00619. CARD. 1 hit.
    [Graphical view ]
    SMARTi SM00072. GuKc. 1 hit.
    SM00228. PDZ. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47986. SSF47986. 1 hit.
    SSF50156. SSF50156. 1 hit.
    SSF52540. SSF52540. 1 hit.
    PROSITEi PS50209. CARD. 1 hit.
    PS50052. GUANYLATE_KINASE_2. 1 hit.
    PS50106. PDZ. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "CARD11 and CARD14 are novel caspase recruitment domain (CARD)/membrane-associated guanylate kinase (MAGUK) family members that interact with Bcl10 and activate NF-kappaB."
      Bertin J., Wang L., Guo Y., Jacobson M.D., Poyet J.-L., Srinivasula S.M., Merriam S., DiStefano P.S., Alnemri E.S.
      J. Biol. Chem. 276:11877-11882(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT TRP-820.
    2. "Carma1, a CARD-containing binding partner of Bcl10, induces Bcl10 phosphorylation and NF-kappaB activation."
      Gaide O., Martinon F., Micheau O., Bonnet D., Thome M., Tschopp J.
      FEBS Lett. 496:121-127(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT TRP-820.
    3. Erratum
      Gaide O., Martinon F., Micheau O., Bonnet D., Thome M., Tschopp J.
      FEBS Lett. 505:198-198(2001)
    4. "Alternative splicing of CARMA2/CARD14 transcripts generates protein variants with differential effect on NF-kappaB activation and endoplasmic reticulum stress-induced cell death."
      Scudiero I., Zotti T., Ferravante A., Vessichelli M., Vito P., Stilo R.
      J. Cell. Physiol. 226:3121-3131(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3), FUNCTION, INTERACTION WITH BCL10; TRAF2; TRAF3 AND TRAF6, SUBCELLULAR LOCATION, ALTERNATIVE SPLICING.
    5. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
      Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
      , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
      Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
      Tissue: Cervix and Colon.
    7. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
      Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III
      J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-544, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    8. Cited for: TISSUE SPECIFICITY, VARIANTS PSORS2 SER-117 AND ALA-138, CHARACTERIZATION OF VARIANTS PSORS2 SER-117 AND ALA-138.
    9. Cited for: VARIANTS PRP GLU-138 DEL AND PRO-156.
    10. Cited for: VARIANTS CYS-38; GLN-62; ARG-150; ASN-171; HIS-176; HIS-179; LEU-191; ASN-200; GLY-285; ASN-593; TRP-682; SER-714 AND GLU-973, VARIANTS PSORS2 SER-117; ALA-138; LYS-142 AND GLY-142, CHARACTERIZATION OF VARIANTS PSORS2 LYS-142 AND GLY-142.

    Entry informationi

    Entry nameiCAR14_HUMAN
    AccessioniPrimary (citable) accession number: Q9BXL6
    Secondary accession number(s): B8QQJ3, Q9BVB5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 31, 2002
    Last sequence update: May 18, 2010
    Last modified: October 1, 2014
    This is version 118 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Caution

    Supposed to contain a SH3 domain which is not detected by PROSITE, Pfam or SMART.Curated

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3