Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Caspase recruitment domain-containing protein 14

Gene

CARD14

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts as a scaffolding protein that can activate the inflammatory transcription factor NF-kappa-B and p38/JNK MAP kinase signaling pathways. Forms a signaling complex with BCL10 and MALT1, and activates MALT1 proteolytic activity and inflammatory gene expression. MALT1 is indispensable for CARD14-induced activation of NF-kappa-B and p38/JNK MAP kinases (PubMed:11278692, PubMed:21302310, PubMed:27113748, PubMed:27071417). May play a role in signaling mediated by TRAF2, TRAF3 and TRAF6 and protects cells against apoptosis.4 Publications
Isoform 3: Not able to activate the inflammatory transcription factor NF-kappa-B and may fuction as a dominant negative regulator (PubMed:21302310, PubMed:26358359).2 Publications

Caution

Supposed to contain a SH3 domain which is not detected by PROSITE, Pfam or SMART.Curated

GO - Molecular functioni

  • CARD domain binding Source: UniProtKB

GO - Biological processi

  • activation of NF-kappaB-inducing kinase activity Source: UniProtKB
  • apoptotic process Source: UniProtKB-KW
  • negative regulation of apoptotic process Source: UniProtKB
  • positive regulation of NF-kappaB transcription factor activity Source: UniProtKB
  • positive regulation of protein phosphorylation Source: UniProtKB
  • tumor necrosis factor-mediated signaling pathway Source: UniProtKB

Keywordsi

Biological processApoptosis

Names & Taxonomyi

Protein namesi
Recommended name:
Caspase recruitment domain-containing protein 14
Alternative name(s):
CARD-containing MAGUK protein 2
Short name:
Carma 2
Gene namesi
Name:CARD14
Synonyms:CARMA2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000141527.16
HGNCiHGNC:16446 CARD14
MIMi607211 gene
neXtProtiNX_Q9BXL6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Involvement in diseasei

Psoriasis 2 (PSORS2)5 Publications
Disease susceptibility is associated with variations affecting the gene represented in this entry.
Disease descriptionA common, chronic inflammatory disease of the skin with multifactorial etiology. It is characterized by red, scaly plaques usually found on the scalp, elbows and knees. These lesions are caused by abnormal keratinocyte proliferation and infiltration of inflammatory cells into the dermis and epidermis.
See also OMIM:602723
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_07858369R → W in PSORS2; reduces NF-kappa-B activation. 1 PublicationCorresponds to variant dbSNP:rs375624435Ensembl.1
Natural variantiVAR_068225138E → A in PSORS2; increases NF-kappaB transcription factor activity; enhances CBCL10-MALT1-CARD14 complex formation; enhances MALT1 protease activity. 4 PublicationsCorresponds to variant dbSNP:rs281875214EnsemblClinVar.1
Natural variantiVAR_068226142E → G in PSORS2; increases NF-kappaB transcription factor activity. 1 PublicationCorresponds to variant dbSNP:rs281875213EnsemblClinVar.1
Natural variantiVAR_068227142E → K in PSORS2; increases NF-kappaB transcription factor activity; enhances MALT1 protease activity. 2 PublicationsCorresponds to variant dbSNP:rs281875212EnsemblClinVar.1
Natural variantiVAR_068228150L → R in PSORS2; increases NF-kappaB transcription factor activity. 2 PublicationsCorresponds to variant dbSNP:rs146214639EnsemblClinVar.1
Natural variantiVAR_078586151R → Q in PSORS2; unknown pathological significance; decreases NF-kappaB transcription factor activity. 1 PublicationCorresponds to variant dbSNP:rs200731780Ensembl.1
Natural variantiVAR_078587151R → W in PSORS2; unknown pathological significance; decreases NF-kappaB transcription factor activity. 1 PublicationCorresponds to variant dbSNP:rs777305616Ensembl.1
Natural variantiVAR_078588197E → K in PSORS2; increases NF-kappaB transcription factor activity. 1 PublicationCorresponds to variant dbSNP:rs200790561EnsemblClinVar.1
Natural variantiVAR_078589209L → P in PSORS2; unknown pathological significance; no effect on NF-kappaB transcription factor activity. 1 Publication1
Natural variantiVAR_078590216A → T in PSORS2; unknown pathological significance; decreases NF-kappaB transcription factor activity. 1 PublicationCorresponds to variant dbSNP:rs574982768Ensembl.1
Natural variantiVAR_078595420T → A in PSORS2; unknown pathological significance; decreases NF-kappaB transcription factor activity. 1 PublicationCorresponds to variant dbSNP:rs762364495Ensembl.1
Natural variantiVAR_078596602S → L in PSORS2; unknown pathological significance; does not change NF-kappaB transcription factor activity. 1 PublicationCorresponds to variant dbSNP:rs201285077Ensembl.1
Natural variantiVAR_078597639A → G in PSORS2; unknown pathological significance; does not change NF-kappaB transcription factor activity. 1 Publication1
Pityriasis rubra pilaris (PRP)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA rare, papulosquamous skin disease characterized by the appearance of keratotic follicular papules, well-demarcated salmon-colored erythematous plaques covered with fine powdery scales interspersed with distinct islands of uninvolved skin, and palmoplantar keratoderma. Most cases are sporadic. The rare familial cases show autosomal dominant inheritance with incomplete penetrance and variable expression. Familial PRP usually presents at birth or appears during the first years of life and runs a chronic course. It is characterized by prominent follicular hyperkeratosis, diffuse palmoplantar keratoderma, and erythema.
See also OMIM:173200
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_078584127C → S in PRP. 1 Publication1
Natural variantiVAR_078585136Q → L in PRP. 1 Publication1
Natural variantiVAR_068819138Missing in PRP. 1 Publication1
Natural variantiVAR_068820156L → P in PRP. 1 PublicationCorresponds to variant dbSNP:rs387907240EnsemblClinVar.1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNETi79092
MalaCardsiCARD14
MIMi173200 phenotype
602723 phenotype
OpenTargetsiENSG00000141527
Orphaneti2897 Pityriasis rubra pilaris
PharmGKBiPA134959119

Polymorphism and mutation databases

BioMutaiCARD14
DMDMi296434421

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001440881 – 1004Caspase recruitment domain-containing protein 14Add BLAST1004

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei544PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9BXL6
PaxDbiQ9BXL6
PeptideAtlasiQ9BXL6
PRIDEiQ9BXL6

PTM databases

iPTMnetiQ9BXL6
PhosphoSitePlusiQ9BXL6

Expressioni

Tissue specificityi

Isoform 1 is detected in placenta and epidermal keratinocytes (PubMed:22521418). Isoform 2 is detected in leukocytes and fetal brain (PubMed:22521418).1 Publication

Gene expression databases

BgeeiENSG00000141527
CleanExiHS_CARD14
ExpressionAtlasiQ9BXL6 baseline and differential
GenevisibleiQ9BXL6 HS

Interactioni

Subunit structurei

Interacts (via CARD domain) with BCL10 (via CARD domain) (PubMed:21302310). Forms a complex with MALT1 and BCL10; resulting in the formation of a CBM (CARD14-BLC10-MALT1) complex (PubMed:27113748, PubMed:27071417). Interacts with TRAF2, TRAF3 and TRAF6 (PubMed:21302310).3 Publications

GO - Molecular functioni

  • CARD domain binding Source: UniProtKB

Protein-protein interaction databases

BioGridi122540, 9 interactors
IntActiQ9BXL6, 7 interactors
STRINGi9606.ENSP00000344549

Structurei

3D structure databases

ProteinModelPortaliQ9BXL6
SMRiQ9BXL6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini15 – 107CARDPROSITE-ProRule annotationAdd BLAST93
Domaini568 – 658PDZPROSITE-ProRule annotationAdd BLAST91
Domaini807 – 990Guanylate kinase-likePROSITE-ProRule annotationAdd BLAST184

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni409 – 568Maintains the protein in an inactive state1 PublicationAdd BLAST160

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili128 – 409Sequence analysisAdd BLAST282

Domaini

A linker region between the coiled-coil and PDZ region holds the protein in an inactive state (PubMed:27071417).1 Publication

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG0708 Eukaryota
COG0194 LUCA
GeneTreeiENSGT00530000063108
HOGENOMiHOG000049174
HOVERGENiHBG106927
InParanoidiQ9BXL6
KOiK20913
OMAiQIVMVDY
OrthoDBiEOG091G0T58
PhylomeDBiQ9BXL6
TreeFamiTF315606

Family and domain databases

InterProiView protein in InterPro
IPR001315 CARD
IPR011029 DEATH-like_dom_sf
IPR008145 GK/Ca_channel_bsu
IPR008144 Guanylate_kin-like_dom
IPR027417 P-loop_NTPase
IPR001478 PDZ
IPR036034 PDZ_sf
PfamiView protein in Pfam
PF00619 CARD, 1 hit
PF00625 Guanylate_kin, 1 hit
SUPFAMiSSF47986 SSF47986, 1 hit
SSF50156 SSF50156, 1 hit
SSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS50209 CARD, 1 hit
PS50052 GUANYLATE_KINASE_2, 1 hit
PS50106 PDZ, 1 hit

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9BXL6-1) [UniParc]FASTAAdd to basket
Also known as: CARD14fl1 Publication, CARMA2fl1 Publication

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGELCRRDSA LTALDEETLW EMMESHRHRI VRCICPSRLT PYLRQAKVLC
60 70 80 90 100
QLDEEEVLHS PRLTNSAMRA GHLLDLLKTR GKNGAIAFLE SLKFHNPDVY
110 120 130 140 150
TLVTGLQPDV DFSNFSGLME TSKLTECLAG AIGSLQEELN QEKGQKEVLL
160 170 180 190 200
RRCQQLQEHL GLAETRAEGL HQLEADHSRM KREVSAHFHE VLRLKDEMLS
210 220 230 240 250
LSLHYSNALQ EKELAASRCR SLQEELYLLK QELQRANMVS SCELELQEQS
260 270 280 290 300
LRTASDQESG DEELNRLKEE NEKLRSLTFS LAEKDILEQS LDEARGSRQE
310 320 330 340 350
LVERIHSLRE RAVAAERQRE QYWEEKEQTL LQFQKSKMAC QLYREKVNAL
360 370 380 390 400
QAQVCELQKE RDQAYSARDS AQREISQSLV EKDSLRRQVF ELTDQVCELR
410 420 430 440 450
TQLRQLQAEP PGVLKQEART REPCPREKQR LVRMHAICPR DDSDCSLVSS
460 470 480 490 500
TESQLLSDLS ATSSRELVDS FRSSSPAPPS QQSLYKRVAE DFGEEPWSFS
510 520 530 540 550
SCLEIPEGDP GALPGAKAGD PHLDYELLDT ADLPQLESSL QPVSPGRLDV
560 570 580 590 600
SESGVLMRRR PARRILSQVT MLAFQGDALL EQISVIGGNL TGIFIHRVTP
610 620 630 640 650
GSAADQMALR PGTQIVMVDY EASEPLFKAV LEDTTLEEAV GLLRRVDGFC
660 670 680 690 700
CLSVKVNTDG YKRLLQDLEA KVATSGDSFY IRVNLAMEGR AKGELQVHCN
710 720 730 740 750
EVLHVTDTMF QGCGCWHAHR VNSYTMKDTA AHGTIPNYSR AQQQLIALIQ
760 770 780 790 800
DMTQQCTVTR KPSSGGPQKL VRIVSMDKAK ASPLRLSFDR GQLDPSRMEG
810 820 830 840 850
SSTCFWAESC LTLVPYTLVR PHRPARPRPV LLVPRAVGKI LSEKLCLLQG
860 870 880 890 900
FKKCLAEYLS QEEYEAWSQR GDIIQEGEVS GGRCWVTRHA VESLMEKNTH
910 920 930 940 950
ALLDVQLDSV CTLHRMDIFP IVIHVSVNEK MAKKLKKGLQ RLGTSEEQLL
960 970 980 990 1000
EAARQEEGDL DRAPCLYSSL APDGWSDLDG LLSCVRQAIA DEQKKVVWTE

QSPR
Length:1,004
Mass (Da):113,270
Last modified:May 18, 2010 - v2
Checksum:i761CBAC219956076
GO
Isoform 2 (identifier: Q9BXL6-2) [UniParc]FASTAAdd to basket
Also known as: Short, CARD14sh1 Publication, CARMA2sh1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     741-1004: Missing.

Show »
Length:740
Mass (Da):83,679
Checksum:i90FCA1B1C2DB28D1
GO
Isoform 3 (identifier: Q9BXL6-3) [UniParc]FASTAAdd to basket
Also known as: Cardless, CARD14cardless, CARMA2cl1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     1-237: Missing.
     619-671: DYEASEPLFK...KRLLQDLEAK → SRARPLLSPG...WADVKRSAHL
     672-1004: Missing.

Show »
Length:434
Mass (Da):48,505
Checksum:iD351699781B6D6EB
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06822238R → C1 PublicationCorresponds to variant dbSNP:rs281875217EnsemblClinVar.1
Natural variantiVAR_06822362R → Q2 PublicationsCorresponds to variant dbSNP:rs115582620EnsemblClinVar.1
Natural variantiVAR_07858369R → W in PSORS2; reduces NF-kappa-B activation. 1 PublicationCorresponds to variant dbSNP:rs375624435Ensembl.1
Natural variantiVAR_068224117G → S in PSORS2 and PRP; may result in altered splicing of exon 3; increases NF-kappaB transcription factor activity; enhances CBCL10-MALT1-CARD14 complex formation; enhances MALT1 protease activity. 6 PublicationsCorresponds to variant dbSNP:rs281875215EnsemblClinVar.1
Natural variantiVAR_078584127C → S in PRP. 1 Publication1
Natural variantiVAR_078585136Q → L in PRP. 1 Publication1
Natural variantiVAR_068225138E → A in PSORS2; increases NF-kappaB transcription factor activity; enhances CBCL10-MALT1-CARD14 complex formation; enhances MALT1 protease activity. 4 PublicationsCorresponds to variant dbSNP:rs281875214EnsemblClinVar.1
Natural variantiVAR_068819138Missing in PRP. 1 Publication1
Natural variantiVAR_068226142E → G in PSORS2; increases NF-kappaB transcription factor activity. 1 PublicationCorresponds to variant dbSNP:rs281875213EnsemblClinVar.1
Natural variantiVAR_068227142E → K in PSORS2; increases NF-kappaB transcription factor activity; enhances MALT1 protease activity. 2 PublicationsCorresponds to variant dbSNP:rs281875212EnsemblClinVar.1
Natural variantiVAR_068228150L → R in PSORS2; increases NF-kappaB transcription factor activity. 2 PublicationsCorresponds to variant dbSNP:rs146214639EnsemblClinVar.1
Natural variantiVAR_078586151R → Q in PSORS2; unknown pathological significance; decreases NF-kappaB transcription factor activity. 1 PublicationCorresponds to variant dbSNP:rs200731780Ensembl.1
Natural variantiVAR_078587151R → W in PSORS2; unknown pathological significance; decreases NF-kappaB transcription factor activity. 1 PublicationCorresponds to variant dbSNP:rs777305616Ensembl.1
Natural variantiVAR_068820156L → P in PRP. 1 PublicationCorresponds to variant dbSNP:rs387907240EnsemblClinVar.1
Natural variantiVAR_068229171H → N May be associated with susceptibility to psoriasis; does not change MALT1 protease activity. 2 PublicationsCorresponds to variant dbSNP:rs281875216EnsemblClinVar.1
Natural variantiVAR_068230176D → H2 PublicationsCorresponds to variant dbSNP:rs144475004Ensembl.1
Natural variantiVAR_068231179R → H1 PublicationCorresponds to variant dbSNP:rs199517469EnsemblClinVar.1
Natural variantiVAR_068232191V → L1 PublicationCorresponds to variant dbSNP:rs281875218EnsemblClinVar.1
Natural variantiVAR_078588197E → K in PSORS2; increases NF-kappaB transcription factor activity. 1 PublicationCorresponds to variant dbSNP:rs200790561EnsemblClinVar.1
Natural variantiVAR_068233200S → N2 PublicationsCorresponds to variant dbSNP:rs114688446EnsemblClinVar.1
Natural variantiVAR_078589209L → P in PSORS2; unknown pathological significance; no effect on NF-kappaB transcription factor activity. 1 Publication1
Natural variantiVAR_078590216A → T in PSORS2; unknown pathological significance; decreases NF-kappaB transcription factor activity. 1 PublicationCorresponds to variant dbSNP:rs574982768Ensembl.1
Natural variantiVAR_078591218R → C Polymorphism; unknown pathological significance; decreases NF-kappaB transcription factor activity. 1 PublicationCorresponds to variant dbSNP:rs747854314Ensembl.1
Natural variantiVAR_068234285D → G May be associated with susceptibility to psoriasis. 1 PublicationCorresponds to variant dbSNP:rs281875219EnsemblClinVar.1
Natural variantiVAR_078592338M → V Polymorphism; unknown pathological significance; does not change NF-kappaB transcription factor activity. 1 PublicationCorresponds to variant dbSNP:rs200132496Ensembl.1
Natural variantiVAR_078593350L → P1 Publication1
Natural variantiVAR_078594357L → P1 Publication1
Natural variantiVAR_078595420T → A in PSORS2; unknown pathological significance; decreases NF-kappaB transcription factor activity. 1 PublicationCorresponds to variant dbSNP:rs762364495Ensembl.1
Natural variantiVAR_024401547R → S. Corresponds to variant dbSNP:rs2066964EnsemblClinVar.1
Natural variantiVAR_048608585V → I. Corresponds to variant dbSNP:rs34367357Ensembl.1
Natural variantiVAR_068235593I → N1 PublicationCorresponds to variant dbSNP:rs281875220EnsemblClinVar.1
Natural variantiVAR_078596602S → L in PSORS2; unknown pathological significance; does not change NF-kappaB transcription factor activity. 1 PublicationCorresponds to variant dbSNP:rs201285077Ensembl.1
Natural variantiVAR_078597639A → G in PSORS2; unknown pathological significance; does not change NF-kappaB transcription factor activity. 1 Publication1
Natural variantiVAR_068236682R → W1 PublicationCorresponds to variant dbSNP:rs117918077EnsemblClinVar.1
Natural variantiVAR_068237714G → S1 PublicationCorresponds to variant dbSNP:rs151150961EnsemblClinVar.1
Natural variantiVAR_059196820R → W2 PublicationsCorresponds to variant dbSNP:rs11652075EnsemblClinVar.1
Natural variantiVAR_022043883R → H. Corresponds to variant dbSNP:rs2289541EnsemblClinVar.1
Natural variantiVAR_061080962R → Q. Corresponds to variant dbSNP:rs34850974EnsemblClinVar.1
Natural variantiVAR_068238973D → E1 PublicationCorresponds to variant dbSNP:rs144285237EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0474001 – 237Missing in isoform 3. 2 PublicationsAdd BLAST237
Alternative sequenceiVSP_047401619 – 671DYEAS…DLEAK → SRARPLLSPGLLMGTVAAGG VTQADFTSPRRCRSTLGWAS ALSWADVKRSAHL in isoform 3. 2 PublicationsAdd BLAST53
Alternative sequenceiVSP_047402672 – 1004Missing in isoform 3. 2 PublicationsAdd BLAST333
Alternative sequenceiVSP_047403741 – 1004Missing in isoform 2. 2 PublicationsAdd BLAST264

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF322642 mRNA Translation: AAG53403.1
AY032927 mRNA Translation: AAK54453.1
EU652409 mRNA Translation: ACF49506.1
AC087741 Genomic DNA No translation available.
BC018142 mRNA Translation: AAH18142.1
BC001326 mRNA Translation: AAH01326.1
CCDSiCCDS11768.1 [Q9BXL6-1]
CCDS58605.1 [Q9BXL6-2]
RefSeqiNP_001244899.1, NM_001257970.1 [Q9BXL6-2]
NP_077015.2, NM_024110.4 [Q9BXL6-1]
NP_438170.1, NM_052819.2 [Q9BXL6-3]
XP_011523514.1, XM_011525212.1 [Q9BXL6-1]
XP_011523515.1, XM_011525213.1 [Q9BXL6-1]
XP_011523517.1, XM_011525215.1 [Q9BXL6-1]
XP_011523518.1, XM_011525216.1 [Q9BXL6-1]
XP_011523519.1, XM_011525217.1 [Q9BXL6-1]
XP_011523520.1, XM_011525218.2 [Q9BXL6-1]
UniGeneiHs.675480
Hs.696253
Hs.735899

Genome annotation databases

EnsembliENST00000344227; ENSP00000344549; ENSG00000141527 [Q9BXL6-1]
ENST00000570421; ENSP00000461806; ENSG00000141527 [Q9BXL6-2]
ENST00000573882; ENSP00000458715; ENSG00000141527 [Q9BXL6-1]
GeneIDi79092
KEGGihsa:79092
UCSCiuc002jxw.3 human [Q9BXL6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiCAR14_HUMAN
AccessioniPrimary (citable) accession number: Q9BXL6
Secondary accession number(s): B8QQJ3, Q9BVB5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 31, 2002
Last sequence update: May 18, 2010
Last modified: May 23, 2018
This is version 151 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health