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Q9BXL6

- CAR14_HUMAN

UniProt

Q9BXL6 - CAR14_HUMAN

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Protein

Caspase recruitment domain-containing protein 14

Gene

CARD14

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Plays a role in signaling mediated by TRAF2, TRAF3 and TRAF6 and protects cells against apoptosis. Activates NF-kappa-B via BCL10 and IKK. Stimulates the phosphorylation of BCL10.1 Publication

GO - Molecular functioni

  1. CARD domain binding Source: UniProtKB

GO - Biological processi

  1. activation of NF-kappaB-inducing kinase activity Source: UniProtKB
  2. apoptotic process Source: UniProtKB-KW
  3. negative regulation of apoptotic process Source: UniProtKB
  4. positive regulation of NF-kappaB transcription factor activity Source: UniProtKB
  5. positive regulation of protein phosphorylation Source: UniProtKB
  6. tumor necrosis factor-mediated signaling pathway Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Apoptosis

Names & Taxonomyi

Protein namesi
Recommended name:
Caspase recruitment domain-containing protein 14
Alternative name(s):
CARD-containing MAGUK protein 2
Short name:
Carma 2
Gene namesi
Name:CARD14
Synonyms:CARMA2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 17

Organism-specific databases

HGNCiHGNC:16446. CARD14.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
  2. plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Involvement in diseasei

Psoriasis 2 (PSORS2) [MIM:602723]: A common, chronic inflammatory disease of the skin with multifactorial etiology. It is characterized by red, scaly plaques usually found on the scalp, elbows and knees. These lesions are caused by abnormal keratinocyte proliferation and infiltration of inflammatory cells into the dermis and epidermis.2 Publications
Note: Disease susceptibility is associated with variations affecting the gene represented in this entry.
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti117 – 1171G → S in PSORS2; may result in altered splicing of exon 3; results in increased NF-kappa-B activation. 2 Publications
Corresponds to variant rs281875215 [ dbSNP | Ensembl ].
VAR_068224
Natural varianti138 – 1381E → A in PSORS2; results in increased NF-kappa-B activation. 2 Publications
Corresponds to variant rs281875214 [ dbSNP | Ensembl ].
VAR_068225
Natural varianti142 – 1421E → G in PSORS2; results in increased NF-kappa-B activation. 1 Publication
Corresponds to variant rs281875213 [ dbSNP | Ensembl ].
VAR_068226
Natural varianti142 – 1421E → K in PSORS2; results in increased NF-kappa-B activation. 1 Publication
Corresponds to variant rs281875212 [ dbSNP | Ensembl ].
VAR_068227
Pityriasis rubra pilaris (PRP) [MIM:173200]: A rare, papulosquamous skin disease characterized by the appearance of keratotic follicular papules, well-demarcated salmon-colored erythematous plaques covered with fine powdery scales interspersed with distinct islands of uninvolved skin, and palmoplantar keratoderma. Most cases are sporadic. The rare familial cases show autosomal dominant inheritance with incomplete penetrance and variable expression. Familial PRP usually presents at birth or appears during the first years of life and runs a chronic course. It is characterized by prominent follicular hyperkeratosis, diffuse palmoplantar keratoderma, and erythema.1 Publication
Note: The disease is caused by mutations affecting the gene represented in this entry.
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti138 – 1381Missing in PRP. 1 Publication
VAR_068819
Natural varianti156 – 1561L → P in PRP. 1 Publication
VAR_068820

Keywords - Diseasei

Disease mutation

Organism-specific databases

MIMi173200. phenotype.
602723. phenotype.
Orphaneti2897. Pityriasis rubra pilaris.
PharmGKBiPA134959119.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10041004Caspase recruitment domain-containing protein 14PRO_0000144088Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei544 – 5441Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9BXL6.
PaxDbiQ9BXL6.
PRIDEiQ9BXL6.

PTM databases

PhosphoSiteiQ9BXL6.

Expressioni

Tissue specificityi

Isoform 1 is detected in placenta and epidermal keratinocytes. Isoform 2 is detected in leukocytes and fetal brain.1 Publication

Gene expression databases

BgeeiQ9BXL6.
CleanExiHS_CARD14.
ExpressionAtlasiQ9BXL6. baseline.
GenevestigatoriQ9BXL6.

Organism-specific databases

HPAiHPA022533.
HPA023388.

Interactioni

Subunit structurei

Interacts with BCL10 by CARD-CARD interaction. Interacts with TRAF2, TRAF3 and TRAF6.1 Publication

Protein-protein interaction databases

BioGridi122540. 3 interactions.
IntActiQ9BXL6. 1 interaction.
MINTiMINT-193865.
STRINGi9606.ENSP00000344549.

Structurei

3D structure databases

ProteinModelPortaliQ9BXL6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini15 – 10793CARDPROSITE-ProRule annotationAdd
BLAST
Domaini568 – 65891PDZPROSITE-ProRule annotationAdd
BLAST
Domaini807 – 990184Guanylate kinase-likePROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili128 – 409282Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Contains 1 CARD domain.PROSITE-ProRule annotation
Contains 1 guanylate kinase-like domain.PROSITE-ProRule annotation
Contains 1 PDZ (DHR) domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG314915.
GeneTreeiENSGT00530000063108.
HOGENOMiHOG000049174.
HOVERGENiHBG106927.
InParanoidiQ9BXL6.
OMAiMEKNTHA.
OrthoDBiEOG747PH5.
PhylomeDBiQ9BXL6.
TreeFamiTF315606.

Family and domain databases

Gene3Di1.10.533.10. 1 hit.
2.30.42.10. 1 hit.
3.40.50.300. 1 hit.
InterProiIPR001315. CARD.
IPR011029. DEATH-like_dom.
IPR008145. GK/Ca_channel_bsu.
IPR008144. Guanylate_kin-like.
IPR027417. P-loop_NTPase.
IPR001478. PDZ.
[Graphical view]
PfamiPF00619. CARD. 1 hit.
[Graphical view]
SMARTiSM00072. GuKc. 1 hit.
SM00228. PDZ. 1 hit.
[Graphical view]
SUPFAMiSSF47986. SSF47986. 1 hit.
SSF50156. SSF50156. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEiPS50209. CARD. 1 hit.
PS50052. GUANYLATE_KINASE_2. 1 hit.
PS50106. PDZ. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9BXL6) [UniParc]FASTAAdd to Basket

Also known as: CARMA2fl

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGELCRRDSA LTALDEETLW EMMESHRHRI VRCICPSRLT PYLRQAKVLC
60 70 80 90 100
QLDEEEVLHS PRLTNSAMRA GHLLDLLKTR GKNGAIAFLE SLKFHNPDVY
110 120 130 140 150
TLVTGLQPDV DFSNFSGLME TSKLTECLAG AIGSLQEELN QEKGQKEVLL
160 170 180 190 200
RRCQQLQEHL GLAETRAEGL HQLEADHSRM KREVSAHFHE VLRLKDEMLS
210 220 230 240 250
LSLHYSNALQ EKELAASRCR SLQEELYLLK QELQRANMVS SCELELQEQS
260 270 280 290 300
LRTASDQESG DEELNRLKEE NEKLRSLTFS LAEKDILEQS LDEARGSRQE
310 320 330 340 350
LVERIHSLRE RAVAAERQRE QYWEEKEQTL LQFQKSKMAC QLYREKVNAL
360 370 380 390 400
QAQVCELQKE RDQAYSARDS AQREISQSLV EKDSLRRQVF ELTDQVCELR
410 420 430 440 450
TQLRQLQAEP PGVLKQEART REPCPREKQR LVRMHAICPR DDSDCSLVSS
460 470 480 490 500
TESQLLSDLS ATSSRELVDS FRSSSPAPPS QQSLYKRVAE DFGEEPWSFS
510 520 530 540 550
SCLEIPEGDP GALPGAKAGD PHLDYELLDT ADLPQLESSL QPVSPGRLDV
560 570 580 590 600
SESGVLMRRR PARRILSQVT MLAFQGDALL EQISVIGGNL TGIFIHRVTP
610 620 630 640 650
GSAADQMALR PGTQIVMVDY EASEPLFKAV LEDTTLEEAV GLLRRVDGFC
660 670 680 690 700
CLSVKVNTDG YKRLLQDLEA KVATSGDSFY IRVNLAMEGR AKGELQVHCN
710 720 730 740 750
EVLHVTDTMF QGCGCWHAHR VNSYTMKDTA AHGTIPNYSR AQQQLIALIQ
760 770 780 790 800
DMTQQCTVTR KPSSGGPQKL VRIVSMDKAK ASPLRLSFDR GQLDPSRMEG
810 820 830 840 850
SSTCFWAESC LTLVPYTLVR PHRPARPRPV LLVPRAVGKI LSEKLCLLQG
860 870 880 890 900
FKKCLAEYLS QEEYEAWSQR GDIIQEGEVS GGRCWVTRHA VESLMEKNTH
910 920 930 940 950
ALLDVQLDSV CTLHRMDIFP IVIHVSVNEK MAKKLKKGLQ RLGTSEEQLL
960 970 980 990 1000
EAARQEEGDL DRAPCLYSSL APDGWSDLDG LLSCVRQAIA DEQKKVVWTE

QSPR
Length:1,004
Mass (Da):113,270
Last modified:May 18, 2010 - v2
Checksum:i761CBAC219956076
GO
Isoform 2 (identifier: Q9BXL6-2) [UniParc]FASTAAdd to Basket

Also known as: Short, CARMA2sh

The sequence of this isoform differs from the canonical sequence as follows:
     741-1004: Missing.

Show »
Length:740
Mass (Da):83,679
Checksum:i90FCA1B1C2DB28D1
GO
Isoform 3 (identifier: Q9BXL6-3) [UniParc]FASTAAdd to Basket

Also known as: Cardless, CARMA2cl

The sequence of this isoform differs from the canonical sequence as follows:
     1-237: Missing.
     619-671: DYEASEPLFK...KRLLQDLEAK → SRARPLLSPG...WADVKRSAHL
     672-1004: Missing.

Show »
Length:434
Mass (Da):48,505
Checksum:iD351699781B6D6EB
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti38 – 381R → C.1 Publication
Corresponds to variant rs281875217 [ dbSNP | Ensembl ].
VAR_068222
Natural varianti62 – 621R → Q.1 Publication
Corresponds to variant rs115582620 [ dbSNP | Ensembl ].
VAR_068223
Natural varianti117 – 1171G → S in PSORS2; may result in altered splicing of exon 3; results in increased NF-kappa-B activation. 2 Publications
Corresponds to variant rs281875215 [ dbSNP | Ensembl ].
VAR_068224
Natural varianti138 – 1381E → A in PSORS2; results in increased NF-kappa-B activation. 2 Publications
Corresponds to variant rs281875214 [ dbSNP | Ensembl ].
VAR_068225
Natural varianti138 – 1381Missing in PRP. 1 Publication
VAR_068819
Natural varianti142 – 1421E → G in PSORS2; results in increased NF-kappa-B activation. 1 Publication
Corresponds to variant rs281875213 [ dbSNP | Ensembl ].
VAR_068226
Natural varianti142 – 1421E → K in PSORS2; results in increased NF-kappa-B activation. 1 Publication
Corresponds to variant rs281875212 [ dbSNP | Ensembl ].
VAR_068227
Natural varianti150 – 1501L → R.1 Publication
Corresponds to variant rs146214639 [ dbSNP | Ensembl ].
VAR_068228
Natural varianti156 – 1561L → P in PRP. 1 Publication
VAR_068820
Natural varianti171 – 1711H → N May be associated with susceptibility to psoriasis. 1 Publication
Corresponds to variant rs281875216 [ dbSNP | Ensembl ].
VAR_068229
Natural varianti176 – 1761D → H.1 Publication
Corresponds to variant rs144475004 [ dbSNP | Ensembl ].
VAR_068230
Natural varianti179 – 1791R → H.1 Publication
Corresponds to variant rs199517469 [ dbSNP | Ensembl ].
VAR_068231
Natural varianti191 – 1911V → L.1 Publication
Corresponds to variant rs281875218 [ dbSNP | Ensembl ].
VAR_068232
Natural varianti200 – 2001S → N.1 Publication
Corresponds to variant rs114688446 [ dbSNP | Ensembl ].
VAR_068233
Natural varianti285 – 2851D → G May be associated with susceptibility to psoriasis. 1 Publication
Corresponds to variant rs281875219 [ dbSNP | Ensembl ].
VAR_068234
Natural varianti547 – 5471R → S.
Corresponds to variant rs2066964 [ dbSNP | Ensembl ].
VAR_024401
Natural varianti585 – 5851V → I.
Corresponds to variant rs34367357 [ dbSNP | Ensembl ].
VAR_048608
Natural varianti593 – 5931I → N.1 Publication
Corresponds to variant rs281875220 [ dbSNP | Ensembl ].
VAR_068235
Natural varianti682 – 6821R → W.1 Publication
Corresponds to variant rs117918077 [ dbSNP | Ensembl ].
VAR_068236
Natural varianti714 – 7141G → S.1 Publication
Corresponds to variant rs151150961 [ dbSNP | Ensembl ].
VAR_068237
Natural varianti820 – 8201R → W.2 Publications
Corresponds to variant rs11652075 [ dbSNP | Ensembl ].
VAR_059196
Natural varianti883 – 8831R → H.
Corresponds to variant rs2289541 [ dbSNP | Ensembl ].
VAR_022043
Natural varianti962 – 9621R → Q.
Corresponds to variant rs34850974 [ dbSNP | Ensembl ].
VAR_061080
Natural varianti973 – 9731D → E.1 Publication
Corresponds to variant rs144285237 [ dbSNP | Ensembl ].
VAR_068238

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 237237Missing in isoform 3. 2 PublicationsVSP_047400Add
BLAST
Alternative sequencei619 – 67153DYEAS…DLEAK → SRARPLLSPGLLMGTVAAGG VTQADFTSPRRCRSTLGWAS ALSWADVKRSAHL in isoform 3. 2 PublicationsVSP_047401Add
BLAST
Alternative sequencei672 – 1004333Missing in isoform 3. 2 PublicationsVSP_047402Add
BLAST
Alternative sequencei741 – 1004264Missing in isoform 2. 2 PublicationsVSP_047403Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF322642 mRNA. Translation: AAG53403.1.
AY032927 mRNA. Translation: AAK54453.1.
EU652409 mRNA. Translation: ACF49506.1.
AC087741 Genomic DNA. No translation available.
BC018142 mRNA. Translation: AAH18142.1.
BC001326 mRNA. Translation: AAH01326.1.
CCDSiCCDS11768.1. [Q9BXL6-1]
CCDS58605.1. [Q9BXL6-2]
RefSeqiNP_001244899.1. NM_001257970.1. [Q9BXL6-2]
NP_077015.2. NM_024110.4. [Q9BXL6-1]
NP_438170.1. NM_052819.2. [Q9BXL6-3]
UniGeneiHs.675480.
Hs.696253.
Hs.735899.

Genome annotation databases

EnsembliENST00000344227; ENSP00000344549; ENSG00000141527. [Q9BXL6-1]
ENST00000570421; ENSP00000461806; ENSG00000141527. [Q9BXL6-2]
ENST00000573882; ENSP00000458715; ENSG00000141527. [Q9BXL6-1]
GeneIDi79092.
KEGGihsa:79092.
UCSCiuc002jxv.3. human. [Q9BXL6-1]
uc002jxx.3. human.

Polymorphism databases

DMDMi296434421.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Caspase recruitment domain family, member 14 (CARD14)

Leiden Open Variation Database (LOVD)

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF322642 mRNA. Translation: AAG53403.1 .
AY032927 mRNA. Translation: AAK54453.1 .
EU652409 mRNA. Translation: ACF49506.1 .
AC087741 Genomic DNA. No translation available.
BC018142 mRNA. Translation: AAH18142.1 .
BC001326 mRNA. Translation: AAH01326.1 .
CCDSi CCDS11768.1. [Q9BXL6-1 ]
CCDS58605.1. [Q9BXL6-2 ]
RefSeqi NP_001244899.1. NM_001257970.1. [Q9BXL6-2 ]
NP_077015.2. NM_024110.4. [Q9BXL6-1 ]
NP_438170.1. NM_052819.2. [Q9BXL6-3 ]
UniGenei Hs.675480.
Hs.696253.
Hs.735899.

3D structure databases

ProteinModelPortali Q9BXL6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 122540. 3 interactions.
IntActi Q9BXL6. 1 interaction.
MINTi MINT-193865.
STRINGi 9606.ENSP00000344549.

PTM databases

PhosphoSitei Q9BXL6.

Polymorphism databases

DMDMi 296434421.

Proteomic databases

MaxQBi Q9BXL6.
PaxDbi Q9BXL6.
PRIDEi Q9BXL6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000344227 ; ENSP00000344549 ; ENSG00000141527 . [Q9BXL6-1 ]
ENST00000570421 ; ENSP00000461806 ; ENSG00000141527 . [Q9BXL6-2 ]
ENST00000573882 ; ENSP00000458715 ; ENSG00000141527 . [Q9BXL6-1 ]
GeneIDi 79092.
KEGGi hsa:79092.
UCSCi uc002jxv.3. human. [Q9BXL6-1 ]
uc002jxx.3. human.

Organism-specific databases

CTDi 79092.
GeneCardsi GC17P078152.
H-InvDB HIX0173685.
HGNCi HGNC:16446. CARD14.
HPAi HPA022533.
HPA023388.
MIMi 173200. phenotype.
602723. phenotype.
607211. gene.
neXtProti NX_Q9BXL6.
Orphaneti 2897. Pityriasis rubra pilaris.
PharmGKBi PA134959119.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG314915.
GeneTreei ENSGT00530000063108.
HOGENOMi HOG000049174.
HOVERGENi HBG106927.
InParanoidi Q9BXL6.
OMAi MEKNTHA.
OrthoDBi EOG747PH5.
PhylomeDBi Q9BXL6.
TreeFami TF315606.

Miscellaneous databases

ChiTaRSi CARD14. human.
GeneWikii CARD14.
GenomeRNAii 79092.
NextBioi 67933.
PROi Q9BXL6.
SOURCEi Search...

Gene expression databases

Bgeei Q9BXL6.
CleanExi HS_CARD14.
ExpressionAtlasi Q9BXL6. baseline.
Genevestigatori Q9BXL6.

Family and domain databases

Gene3Di 1.10.533.10. 1 hit.
2.30.42.10. 1 hit.
3.40.50.300. 1 hit.
InterProi IPR001315. CARD.
IPR011029. DEATH-like_dom.
IPR008145. GK/Ca_channel_bsu.
IPR008144. Guanylate_kin-like.
IPR027417. P-loop_NTPase.
IPR001478. PDZ.
[Graphical view ]
Pfami PF00619. CARD. 1 hit.
[Graphical view ]
SMARTi SM00072. GuKc. 1 hit.
SM00228. PDZ. 1 hit.
[Graphical view ]
SUPFAMi SSF47986. SSF47986. 1 hit.
SSF50156. SSF50156. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEi PS50209. CARD. 1 hit.
PS50052. GUANYLATE_KINASE_2. 1 hit.
PS50106. PDZ. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "CARD11 and CARD14 are novel caspase recruitment domain (CARD)/membrane-associated guanylate kinase (MAGUK) family members that interact with Bcl10 and activate NF-kappaB."
    Bertin J., Wang L., Guo Y., Jacobson M.D., Poyet J.-L., Srinivasula S.M., Merriam S., DiStefano P.S., Alnemri E.S.
    J. Biol. Chem. 276:11877-11882(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT TRP-820.
  2. "Carma1, a CARD-containing binding partner of Bcl10, induces Bcl10 phosphorylation and NF-kappaB activation."
    Gaide O., Martinon F., Micheau O., Bonnet D., Thome M., Tschopp J.
    FEBS Lett. 496:121-127(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT TRP-820.
  3. Erratum
    Gaide O., Martinon F., Micheau O., Bonnet D., Thome M., Tschopp J.
    FEBS Lett. 505:198-198(2001)
  4. "Alternative splicing of CARMA2/CARD14 transcripts generates protein variants with differential effect on NF-kappaB activation and endoplasmic reticulum stress-induced cell death."
    Scudiero I., Zotti T., Ferravante A., Vessichelli M., Vito P., Stilo R.
    J. Cell. Physiol. 226:3121-3131(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3), FUNCTION, INTERACTION WITH BCL10; TRAF2; TRAF3 AND TRAF6, SUBCELLULAR LOCATION, ALTERNATIVE SPLICING.
  5. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
    Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
    , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
    Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
    Tissue: Cervix and Colon.
  7. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
    Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III
    J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-544, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  8. Cited for: TISSUE SPECIFICITY, VARIANTS PSORS2 SER-117 AND ALA-138, CHARACTERIZATION OF VARIANTS PSORS2 SER-117 AND ALA-138.
  9. Cited for: VARIANTS PRP GLU-138 DEL AND PRO-156.
  10. Cited for: VARIANTS CYS-38; GLN-62; ARG-150; ASN-171; HIS-176; HIS-179; LEU-191; ASN-200; GLY-285; ASN-593; TRP-682; SER-714 AND GLU-973, VARIANTS PSORS2 SER-117; ALA-138; LYS-142 AND GLY-142, CHARACTERIZATION OF VARIANTS PSORS2 LYS-142 AND GLY-142.

Entry informationi

Entry nameiCAR14_HUMAN
AccessioniPrimary (citable) accession number: Q9BXL6
Secondary accession number(s): B8QQJ3, Q9BVB5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 31, 2002
Last sequence update: May 18, 2010
Last modified: October 29, 2014
This is version 119 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Supposed to contain a SH3 domain which is not detected by PROSITE, Pfam or SMART.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3