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Protein

Hemogen

Gene

HEMGN

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regulates the proliferation and differentiation of hematopoietic cells. Overexpression block the TPA-induced megakaryocytic differentiation in the K562 cell model. May also prevent cell apoptosis through the activation of the nuclear factor-kappa B (NF-kB).3 Publications

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein
Biological processDifferentiation

Names & Taxonomyi

Protein namesi
Recommended name:
Hemogen
Alternative name(s):
Erythroid differentiation-associated gene protein
Short name:
EDAG-1
Hemopoietic gene protein
Negative differentiation regulator protein
Gene namesi
Name:HEMGN
Synonyms:EDAG, NDR
ORF Names:PRO1037, PRO1620
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000136929.12
HGNCiHGNC:17509 HEMGN
MIMi610715 gene
neXtProtiNX_Q9BXL5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi55363
OpenTargetsiENSG00000136929
PharmGKBiPA38458

Polymorphism and mutation databases

DMDMi74752432

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002453611 – 484HemogenAdd BLAST484

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei123PhosphoserineCombined sources1
Modified residuei159PhosphoserineBy similarity1
Modified residuei181PhosphoserineCombined sources1
Modified residuei188PhosphoserineCombined sources1
Modified residuei201PhosphoserineCombined sources1
Modified residuei246PhosphothreonineBy similarity1
Modified residuei349PhosphoserineCombined sources1
Modified residuei353PhosphoserineCombined sources1
Modified residuei360PhosphothreonineCombined sources1
Modified residuei363PhosphoserineCombined sources1
Modified residuei367PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9BXL5
PaxDbiQ9BXL5
PeptideAtlasiQ9BXL5
PRIDEiQ9BXL5

PTM databases

iPTMnetiQ9BXL5
PhosphoSitePlusiQ9BXL5

Expressioni

Tissue specificityi

Expressed in hematopoietic precursor cells, thyroid and spermatids (at protein level). Expressed in bone marrow, testis, thymus. Expressed in prostate cancer and ovarian cancer. Also expressed in thymus and thyroid tumors, non-Hodgkin lymphoma, various leukemia cell lines, peripheral blood mononuclear cells (PBMCs) and bone marrow mononuclear cells (BMMCs) of patients with leukemia.6 Publications

Developmental stagei

Expressed in fetal liver, kidney and brain.2 Publications

Inductioni

Down-regulated during megakaryocytic differentiation of K562 cells by 12-O-tetradecanoylphorbol-13-acetate (TPA) (at protein level). Up-regulated in normal PBMCs by mitogens.2 Publications

Gene expression databases

BgeeiENSG00000136929
CleanExiHS_HEMGN
ExpressionAtlasiQ9BXL5 baseline and differential
GenevisibleiQ9BXL5 HS

Organism-specific databases

HPAiHPA019572
HPA019604
HPA019606

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi12064117 interactors.
IntActiQ9BXL5 32 interactors.
MINTiQ9BXL5
STRINGi9606.ENSP00000259456

Structurei

3D structure databases

ProteinModelPortaliQ9BXL5
SMRiQ9BXL5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni7 – 87Necessary for nuclear localizationAdd BLAST81

Phylogenomic databases

eggNOGiENOG410IXJU Eukaryota
ENOG411096P LUCA
GeneTreeiENSGT00390000004522
HOGENOMiHOG000061736
HOVERGENiHBG080273
InParanoidiQ9BXL5
OMAiPEIYQET
OrthoDBiEOG091G0D5Q
PhylomeDBiQ9BXL5
TreeFamiTF338654

Family and domain databases

InterProiView protein in InterPro
IPR033272 Hemogen
PANTHERiPTHR15993:SF6 PTHR15993:SF6, 2 hits

Sequencei

Sequence statusi: Complete.

Q9BXL5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDLGKDQSHL KHHQTPDPHQ EENHSPEVIG TWSLRNRELL RKRKAEVHEK
60 70 80 90 100
ETSQWLFGEQ KKRKQQRTGK GNRRGRKRQQ NTELKVEPQP QIEKEIVEKA
110 120 130 140 150
LAPIEKKTEP PGSITKVFPS VASPQKVVPE EHFSEICQES NIYQENFSEY
160 170 180 190 200
QEIAVQNHSS ETCQHVSEPE DLSPKMYQEI SVLQDNSSKI CQDMKEPEDN
210 220 230 240 250
SPNTCQVISV IQDHPFKMYQ DMAKREDLAP KMCQEAAVPK ILPCPTSEDT
260 270 280 290 300
ADLAGCSLQA YPKPDVPKGY ILDTDQNPAE PEEYNETDQG IAETEGLFPK
310 320 330 340 350
IQEIAEPKDL STKTHQESAE PKYLPHKTCN EIIVPKAPSH KTIQETPHSE
360 370 380 390 400
DYSIEINQET PGSEKYSPET YQEIPGLEEY SPEIYQETSQ LEEYSPEIYQ
410 420 430 440 450
ETPGPEDLST ETYKNKDVPK ECFPEPHQET GGPQGQDPKA HQEDAKDAYT
460 470 480
FPQEMKEKPK EEPGIPAILN ESHPENDVYS YVLF
Length:484
Mass (Da):55,341
Last modified:June 1, 2001 - v1
Checksum:iE1464D1C7BEA1F07
GO

Sequence cautioni

The sequence AAF67133 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAF71041 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAG35488 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti78R → K in AAP75762 (PubMed:14648837).Curated1
Sequence conflicti78R → K in AAF67133 (PubMed:15332117).Curated1
Sequence conflicti96 – 97IV → M in AAH48324 (PubMed:15489334).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF322875 mRNA Translation: AAK26295.1
AY244805 mRNA Translation: AAP75762.1
AY255672 mRNA Translation: AAP81221.1
AF228713 mRNA Translation: AAF67133.1 Different initiation.
AL499604 Genomic DNA No translation available.
BC048324 mRNA Translation: AAH48324.1
AF130060 mRNA Translation: AAG35488.1 Different initiation.
AF116617 mRNA Translation: AAF71041.1 Different initiation.
CCDSiCCDS6731.1
RefSeqiNP_060907.2, NM_018437.4
NP_932095.1, NM_197978.2
XP_005252143.1, XM_005252086.1
XP_011517147.1, XM_011518845.2
XP_011517148.1, XM_011518846.2
UniGeneiHs.176626

Genome annotation databases

EnsembliENST00000259456; ENSP00000259456; ENSG00000136929
ENST00000616898; ENSP00000480020; ENSG00000136929
GeneIDi55363
KEGGihsa:55363
UCSCiuc004axy.4 human

Similar proteinsi

Entry informationi

Entry nameiHEMGN_HUMAN
AccessioniPrimary (citable) accession number: Q9BXL5
Secondary accession number(s): Q6XAR3, Q86XY5, Q9NPC0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: June 1, 2001
Last modified: February 28, 2018
This is version 112 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome