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Protein

Hemogen

Gene

HEMGN

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Regulates the proliferation and differentiation of hematopoietic cells. Overexpression block the TPA-induced megakaryocytic differentiation in the K562 cell model. May also prevent cell apoptosis through the activation of the nuclear factor-kappa B (NF-kB).3 Publications

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation

Names & Taxonomyi

Protein namesi
Recommended name:
Hemogen
Alternative name(s):
Erythroid differentiation-associated gene protein
Short name:
EDAG-1
Hemopoietic gene protein
Negative differentiation regulator protein
Gene namesi
Name:HEMGN
Synonyms:EDAG, NDR
ORF Names:PRO1037, PRO1620
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:17509. HEMGN.

Subcellular locationi

  • Nucleus 1 Publication

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi55363.
OpenTargetsiENSG00000136929.
PharmGKBiPA38458.

Polymorphism and mutation databases

DMDMi74752432.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002453611 – 484HemogenAdd BLAST484

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei123PhosphoserineCombined sources1
Modified residuei159PhosphoserineBy similarity1
Modified residuei181PhosphoserineCombined sources1
Modified residuei188PhosphoserineCombined sources1
Modified residuei201PhosphoserineCombined sources1
Modified residuei246PhosphothreonineBy similarity1
Modified residuei349PhosphoserineCombined sources1
Modified residuei353PhosphoserineCombined sources1
Modified residuei360PhosphothreonineCombined sources1
Modified residuei363PhosphoserineCombined sources1
Modified residuei367PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9BXL5.
PaxDbiQ9BXL5.
PeptideAtlasiQ9BXL5.
PRIDEiQ9BXL5.

PTM databases

iPTMnetiQ9BXL5.
PhosphoSitePlusiQ9BXL5.

Expressioni

Tissue specificityi

Expressed in hematopoietic precursor cells, thyroid and spermatids (at protein level). Expressed in bone marrow, testis, thymus. Expressed in prostate cancer and ovarian cancer. Also expressed in thymus and thyroid tumors, non-Hodgkin lymphoma, various leukemia cell lines, peripheral blood mononuclear cells (PBMCs) and bone marrow mononuclear cells (BMMCs) of patients with leukemia.6 Publications

Developmental stagei

Expressed in fetal liver, kidney and brain.2 Publications

Inductioni

Down-regulated during megakaryocytic differentiation of K562 cells by 12-O-tetradecanoylphorbol-13-acetate (TPA) (at protein level). Up-regulated in normal PBMCs by mitogens.2 Publications

Gene expression databases

BgeeiENSG00000136929.
CleanExiHS_HEMGN.
ExpressionAtlasiQ9BXL5. baseline and differential.
GenevisibleiQ9BXL5. HS.

Organism-specific databases

HPAiHPA019572.
HPA019604.
HPA019606.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
CTBP1Q133632EBI-3916399,EBI-908846
NPM1P067487EBI-3916399,EBI-78579

Protein-protein interaction databases

BioGridi120641. 17 interactors.
IntActiQ9BXL5. 32 interactors.
MINTiMINT-7220237.
STRINGi9606.ENSP00000259456.

Structurei

3D structure databases

ProteinModelPortaliQ9BXL5.
SMRiQ9BXL5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni7 – 87Necessary for nuclear localizationAdd BLAST81

Phylogenomic databases

eggNOGiENOG410IXJU. Eukaryota.
ENOG411096P. LUCA.
GeneTreeiENSGT00390000004522.
HOGENOMiHOG000061736.
HOVERGENiHBG080273.
InParanoidiQ9BXL5.
OMAiPEIYQET.
OrthoDBiEOG091G0D5Q.
PhylomeDBiQ9BXL5.
TreeFamiTF338654.

Family and domain databases

InterProiIPR033272. Hemogen.
[Graphical view]
PANTHERiPTHR15993:SF6. PTHR15993:SF6. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9BXL5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDLGKDQSHL KHHQTPDPHQ EENHSPEVIG TWSLRNRELL RKRKAEVHEK
60 70 80 90 100
ETSQWLFGEQ KKRKQQRTGK GNRRGRKRQQ NTELKVEPQP QIEKEIVEKA
110 120 130 140 150
LAPIEKKTEP PGSITKVFPS VASPQKVVPE EHFSEICQES NIYQENFSEY
160 170 180 190 200
QEIAVQNHSS ETCQHVSEPE DLSPKMYQEI SVLQDNSSKI CQDMKEPEDN
210 220 230 240 250
SPNTCQVISV IQDHPFKMYQ DMAKREDLAP KMCQEAAVPK ILPCPTSEDT
260 270 280 290 300
ADLAGCSLQA YPKPDVPKGY ILDTDQNPAE PEEYNETDQG IAETEGLFPK
310 320 330 340 350
IQEIAEPKDL STKTHQESAE PKYLPHKTCN EIIVPKAPSH KTIQETPHSE
360 370 380 390 400
DYSIEINQET PGSEKYSPET YQEIPGLEEY SPEIYQETSQ LEEYSPEIYQ
410 420 430 440 450
ETPGPEDLST ETYKNKDVPK ECFPEPHQET GGPQGQDPKA HQEDAKDAYT
460 470 480
FPQEMKEKPK EEPGIPAILN ESHPENDVYS YVLF
Length:484
Mass (Da):55,341
Last modified:June 1, 2001 - v1
Checksum:iE1464D1C7BEA1F07
GO

Sequence cautioni

The sequence AAF67133 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAF71041 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAG35488 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti78R → K in AAP75762 (PubMed:14648837).Curated1
Sequence conflicti78R → K in AAF67133 (PubMed:15332117).Curated1
Sequence conflicti96 – 97IV → M in AAH48324 (PubMed:15489334).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF322875 mRNA. Translation: AAK26295.1.
AY244805 mRNA. Translation: AAP75762.1.
AY255672 mRNA. Translation: AAP81221.1.
AF228713 mRNA. Translation: AAF67133.1. Different initiation.
AL499604 Genomic DNA. Translation: CAI12808.1.
BC048324 mRNA. Translation: AAH48324.1.
AF130060 mRNA. Translation: AAG35488.1. Different initiation.
AF116617 mRNA. Translation: AAF71041.1. Different initiation.
CCDSiCCDS6731.1.
RefSeqiNP_060907.2. NM_018437.4.
NP_932095.1. NM_197978.2.
XP_005252143.1. XM_005252086.1.
XP_011517147.1. XM_011518845.2.
XP_011517148.1. XM_011518846.2.
UniGeneiHs.176626.

Genome annotation databases

EnsembliENST00000259456; ENSP00000259456; ENSG00000136929.
ENST00000616898; ENSP00000480020; ENSG00000136929.
GeneIDi55363.
KEGGihsa:55363.
UCSCiuc004axy.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF322875 mRNA. Translation: AAK26295.1.
AY244805 mRNA. Translation: AAP75762.1.
AY255672 mRNA. Translation: AAP81221.1.
AF228713 mRNA. Translation: AAF67133.1. Different initiation.
AL499604 Genomic DNA. Translation: CAI12808.1.
BC048324 mRNA. Translation: AAH48324.1.
AF130060 mRNA. Translation: AAG35488.1. Different initiation.
AF116617 mRNA. Translation: AAF71041.1. Different initiation.
CCDSiCCDS6731.1.
RefSeqiNP_060907.2. NM_018437.4.
NP_932095.1. NM_197978.2.
XP_005252143.1. XM_005252086.1.
XP_011517147.1. XM_011518845.2.
XP_011517148.1. XM_011518846.2.
UniGeneiHs.176626.

3D structure databases

ProteinModelPortaliQ9BXL5.
SMRiQ9BXL5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120641. 17 interactors.
IntActiQ9BXL5. 32 interactors.
MINTiMINT-7220237.
STRINGi9606.ENSP00000259456.

PTM databases

iPTMnetiQ9BXL5.
PhosphoSitePlusiQ9BXL5.

Polymorphism and mutation databases

DMDMi74752432.

Proteomic databases

MaxQBiQ9BXL5.
PaxDbiQ9BXL5.
PeptideAtlasiQ9BXL5.
PRIDEiQ9BXL5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000259456; ENSP00000259456; ENSG00000136929.
ENST00000616898; ENSP00000480020; ENSG00000136929.
GeneIDi55363.
KEGGihsa:55363.
UCSCiuc004axy.4. human.

Organism-specific databases

CTDi55363.
DisGeNETi55363.
GeneCardsiHEMGN.
HGNCiHGNC:17509. HEMGN.
HPAiHPA019572.
HPA019604.
HPA019606.
MIMi610715. gene.
neXtProtiNX_Q9BXL5.
OpenTargetsiENSG00000136929.
PharmGKBiPA38458.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IXJU. Eukaryota.
ENOG411096P. LUCA.
GeneTreeiENSGT00390000004522.
HOGENOMiHOG000061736.
HOVERGENiHBG080273.
InParanoidiQ9BXL5.
OMAiPEIYQET.
OrthoDBiEOG091G0D5Q.
PhylomeDBiQ9BXL5.
TreeFamiTF338654.

Miscellaneous databases

ChiTaRSiHEMGN. human.
GeneWikiiHEMGN.
GenomeRNAii55363.
PROiQ9BXL5.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000136929.
CleanExiHS_HEMGN.
ExpressionAtlasiQ9BXL5. baseline and differential.
GenevisibleiQ9BXL5. HS.

Family and domain databases

InterProiIPR033272. Hemogen.
[Graphical view]
PANTHERiPTHR15993:SF6. PTHR15993:SF6. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiHEMGN_HUMAN
AccessioniPrimary (citable) accession number: Q9BXL5
Secondary accession number(s): Q6XAR3, Q86XY5, Q9NPC0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: June 1, 2001
Last modified: November 2, 2016
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.