ID B2L13_HUMAN Reviewed; 485 AA. AC Q9BXK5; B3KPE7; Q96B37; Q96IB7; Q9BY01; Q9HC05; Q9UFE0; Q9UKN3; DT 19-SEP-2002, integrated into UniProtKB/Swiss-Prot. DT 01-JUN-2001, sequence version 1. DT 27-MAR-2024, entry version 196. DE RecName: Full=Bcl-2-like protein 13; DE Short=Bcl2-L-13; DE AltName: Full=Bcl-rambo; DE AltName: Full=Protein Mil1; GN Name=BCL2L13; Synonyms=MIL1; ORFNames=CD003; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2). RX PubMed=11262395; DOI=10.1074/jbc.m010520200; RA Kataoka T., Holler N., Micheau O., Martinon F., Tinel A., Hofmann K., RA Tschopp J.; RT "Bcl-rambo, a novel Bcl-2 homologue that induces apoptosis via its unique RT C-terminal extension."; RL J. Biol. Chem. 276:19548-19554(2001). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). RX PubMed=11381032; DOI=10.1101/gr.154901; RA Footz T.K., Brinkman-Mills P., Banting G.S., Maier S.A., Riazi M.A., RA Bridgland L.J., Hu S., Birren B., Minoshima S., Shimizu N., Pan H., RA Nguyen T., Fang F., Fu Y., Ray L., Wu H., Shaull S., Phan S., Yao Z., RA Chen F., Huan A., Hu P., Wang Q., Loh P., Qi S., Roe B.A., McDermid H.E.; RT "Analysis of the cat eye syndrome critical region in humans and the region RT of conserved synteny in mice: a search for candidate genes at or near the RT human chromosome 22 pericentromere."; RL Genome Res. 11:1053-1070(2001). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). RC TISSUE=Pheochromocytoma; RA Li Y., Peng Y., Li N., Gu W., Han Z., Fu G., Chen Z.; RT "A novel gene expressed in human pheochromocytoma."; RL Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases. RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). RX PubMed=15461802; DOI=10.1186/gb-2004-5-10-r84; RA Collins J.E., Wright C.L., Edwards C.A., Davis M.P., Grinham J.A., RA Cole C.G., Goward M.E., Aguado B., Mallya M., Mokrab Y., Huckle E.J., RA Beare D.M., Dunham I.; RT "A genome annotation-driven approach to cloning the human ORFeome."; RL Genome Biol. 5:R84.1-R84.11(2004). RN [5] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3). RC TISSUE=Teratocarcinoma; RX PubMed=14702039; DOI=10.1038/ng1285; RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., RA Isogai T., Sugano S.; RT "Complete sequencing and characterization of 21,243 full-length human RT cDNAs."; RL Nat. Genet. 36:40-45(2004). RN [6] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=10591208; DOI=10.1038/990031; RA Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., RA Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C., RA Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E., RA Bridgeman A.M., Buck D., Burgess J., Burrill W.D., Burton J., Carder C., RA Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G., RA Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V., RA Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., RA Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A., RA Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C., RA Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E., RA Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F., RA Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M., RA Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A., RA Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D., RA Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., RA Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S., RA Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E., RA Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L., RA Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L., RA Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N., RA Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A., RA Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L., RA Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P., RA Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P., RA Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q., RA Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J., RA Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J., RA Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D., RA Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T., RA Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., RA Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., RA Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R., RA Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L., RA McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J., RA Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E., RA Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P., RA Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y., RA Wright H.; RT "The DNA sequence of human chromosome 22."; RL Nature 402:489-495(1999). RN [7] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), AND VARIANT SER-360. RC TISSUE=Eye, and Skin; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA project: RT the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [8] RP NUCLEOTIDE SEQUENCE [MRNA] OF 77-485 (ISOFORM 2). RC TISSUE=Glial tumor; RA Zemskova M.Y., Lilly M., Escher A.P.; RT "Mil1, a novel human gene encoding mitochondria located protein promoting RT cell survival."; RL Submitted (APR-1999) to the EMBL/GenBank/DDBJ databases. RN [9] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 183-485 (ISOFORM 2). RC TISSUE=Testis; RX PubMed=17974005; DOI=10.1186/1471-2164-8-399; RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., RA Wiemann S., Schupp I.; RT "The full-ORF clone resource of the German cDNA consortium."; RL BMC Genomics 8:399-399(2007). RN [10] RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-38; SER-420 AND SER-426, RP VARIANT [LARGE SCALE ANALYSIS] ARG-46, AND IDENTIFICATION BY MASS RP SPECTROMETRY [LARGE SCALE ANALYSIS]. RC TISSUE=Cervix carcinoma; RX PubMed=18669648; DOI=10.1073/pnas.0805139105; RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., RA Elledge S.J., Gygi S.P.; RT "A quantitative atlas of mitotic phosphorylation."; RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). RN [11] RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-420; SER-426 AND SER-429, AND RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RC TISSUE=Cervix carcinoma; RX PubMed=20068231; DOI=10.1126/scisignal.2000475; RA Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., RA Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.; RT "Quantitative phosphoproteomics reveals widespread full phosphorylation RT site occupancy during mitosis."; RL Sci. Signal. 3:RA3-RA3(2010). RN [12] RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21269460; DOI=10.1186/1752-0509-5-17; RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., RA Bennett K.L., Superti-Furga G., Colinge J.; RT "Initial characterization of the human central proteome."; RL BMC Syst. Biol. 5:17-17(2011). RN [13] RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-420 AND SER-426, AND RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21406692; DOI=10.1126/scisignal.2001570; RA Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., RA Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.; RT "System-wide temporal characterization of the proteome and phosphoproteome RT of human embryonic stem cell differentiation."; RL Sci. Signal. 4:RS3-RS3(2011). RN [14] RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-303; SER-420; SER-426 AND RP SER-444, AND IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RC TISSUE=Cervix carcinoma, and Erythroleukemia; RX PubMed=23186163; DOI=10.1021/pr300630k; RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J., RA Mohammed S.; RT "Toward a comprehensive characterization of a human cancer cell RT phosphoproteome."; RL J. Proteome Res. 12:260-271(2013). RN [15] RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-259; SER-261; SER-326 AND RP SER-410, AND IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RC TISSUE=Liver; RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014; RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., RA Ye M., Zou H.; RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver RT phosphoproteome."; RL J. Proteomics 96:253-262(2014). RN [16] RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=25944712; DOI=10.1002/pmic.201400617; RA Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M., Ayoub D., RA Lane L., Bairoch A., Van Dorsselaer A., Carapito C.; RT "N-terminome analysis of the human mitochondrial proteome."; RL Proteomics 15:2519-2524(2015). CC -!- FUNCTION: May promote the activation of caspase-3 and apoptosis. CC -!- SUBUNIT: Monomer. {ECO:0000305}. CC -!- INTERACTION: CC Q9BXK5; Q15848: ADIPOQ; NbExp=3; IntAct=EBI-747430, EBI-10827839; CC Q9BXK5; Q6RW13-2: AGTRAP; NbExp=3; IntAct=EBI-747430, EBI-11522760; CC Q9BXK5; Q9NVV5-2: AIG1; NbExp=3; IntAct=EBI-747430, EBI-11957045; CC Q9BXK5; P05090: APOD; NbExp=3; IntAct=EBI-747430, EBI-715495; CC Q9BXK5; P29972: AQP1; NbExp=3; IntAct=EBI-747430, EBI-745213; CC Q9BXK5; Q53XK0: BET1; NbExp=3; IntAct=EBI-747430, EBI-10242927; CC Q9BXK5; Q8WVX3-2: C4orf3; NbExp=5; IntAct=EBI-747430, EBI-12003442; CC Q9BXK5; P19397: CD53; NbExp=3; IntAct=EBI-747430, EBI-6657396; CC Q9BXK5; Q8N6F1-2: CLDN19; NbExp=3; IntAct=EBI-747430, EBI-12256978; CC Q9BXK5; Q9BUF7-2: CRB3; NbExp=3; IntAct=EBI-747430, EBI-17233035; CC Q9BXK5; Q9H1M4: DEFB127; NbExp=3; IntAct=EBI-747430, EBI-10305240; CC Q9BXK5; Q9UKR5: ERG28; NbExp=3; IntAct=EBI-747430, EBI-711490; CC Q9BXK5; Q7Z2K6: ERMP1; NbExp=3; IntAct=EBI-747430, EBI-10976398; CC Q9BXK5; Q96KR6: FAM210B; NbExp=3; IntAct=EBI-747430, EBI-18938272; CC Q9BXK5; Q14802-3: FXYD3; NbExp=3; IntAct=EBI-747430, EBI-12175685; CC Q9BXK5; O75084: FZD7; NbExp=3; IntAct=EBI-747430, EBI-746917; CC Q9BXK5; P60520: GABARAPL2; NbExp=4; IntAct=EBI-747430, EBI-720116; CC Q9BXK5; Q10471: GALNT2; NbExp=3; IntAct=EBI-747430, EBI-10226985; CC Q9BXK5; P01350: GAST; NbExp=3; IntAct=EBI-747430, EBI-3436637; CC Q9BXK5; P30519: HMOX2; NbExp=3; IntAct=EBI-747430, EBI-712096; CC Q9BXK5; Q8N5M9: JAGN1; NbExp=3; IntAct=EBI-747430, EBI-10266796; CC Q9BXK5; O60333-2: KIF1B; NbExp=3; IntAct=EBI-747430, EBI-10975473; CC Q9BXK5; O43561-2: LAT; NbExp=3; IntAct=EBI-747430, EBI-8070286; CC Q9BXK5; Q9UBY5: LPAR3; NbExp=3; IntAct=EBI-747430, EBI-12033434; CC Q9BXK5; P21145: MAL; NbExp=5; IntAct=EBI-747430, EBI-3932027; CC Q9BXK5; Q9NZG7: NINJ2; NbExp=3; IntAct=EBI-747430, EBI-10317425; CC Q9BXK5; Q9Y342: PLLP; NbExp=3; IntAct=EBI-747430, EBI-3919291; CC Q9BXK5; P26678: PLN; NbExp=8; IntAct=EBI-747430, EBI-692836; CC Q9BXK5; P60201: PLP1; NbExp=3; IntAct=EBI-747430, EBI-8653150; CC Q9BXK5; P60201-2: PLP1; NbExp=6; IntAct=EBI-747430, EBI-12188331; CC Q9BXK5; Q5VZY2: PLPP4; NbExp=3; IntAct=EBI-747430, EBI-10485931; CC Q9BXK5; Q8IWU4: SLC30A8; NbExp=3; IntAct=EBI-747430, EBI-10262251; CC Q9BXK5; P78382: SLC35A1; NbExp=3; IntAct=EBI-747430, EBI-12870360; CC Q9BXK5; Q96KT7: SLC35G5; NbExp=3; IntAct=EBI-747430, EBI-13598465; CC Q9BXK5; B2RUZ4: SMIM1; NbExp=3; IntAct=EBI-747430, EBI-12188413; CC Q9BXK5; Q08629: SPOCK1; NbExp=3; IntAct=EBI-747430, EBI-2682560; CC Q9BXK5; Q86Y82: STX12; NbExp=3; IntAct=EBI-747430, EBI-2691717; CC Q9BXK5; Q9UNK0: STX8; NbExp=3; IntAct=EBI-747430, EBI-727240; CC Q9BXK5; Q9BZW4: TM6SF2; NbExp=3; IntAct=EBI-747430, EBI-13082040; CC Q9BXK5; Q5BJH2: TMEM128; NbExp=3; IntAct=EBI-747430, EBI-10243515; CC Q9BXK5; Q9P0S9: TMEM14C; NbExp=3; IntAct=EBI-747430, EBI-2339195; CC Q9BXK5; Q9NWH2: TMEM242; NbExp=3; IntAct=EBI-747430, EBI-10315004; CC Q9BXK5; Q8TBM7: TMEM254; NbExp=3; IntAct=EBI-747430, EBI-11956809; CC Q9BXK5; Q9NW97: TMEM51; NbExp=3; IntAct=EBI-747430, EBI-726044; CC Q9BXK5; A0PK05: TMEM72; NbExp=3; IntAct=EBI-747430, EBI-12878352; CC Q9BXK5; Q8N2M4: TMEM86A; NbExp=3; IntAct=EBI-747430, EBI-12015604; CC Q9BXK5; Q8N661: TMEM86B; NbExp=6; IntAct=EBI-747430, EBI-2548832; CC Q9BXK5; Q5BJF2: TMEM97; NbExp=3; IntAct=EBI-747430, EBI-12111910; CC Q9BXK5; Q71RG4: TMUB2; NbExp=3; IntAct=EBI-747430, EBI-2820477; CC Q9BXK5; P01375: TNF; NbExp=3; IntAct=EBI-747430, EBI-359977; CC Q9BXK5; Q9H2S6-2: TNMD; NbExp=3; IntAct=EBI-747430, EBI-12003398; CC Q9BXK5; A5PKU2: TUSC5; NbExp=3; IntAct=EBI-747430, EBI-11988865; CC Q9BXK5; Q15836: VAMP3; NbExp=3; IntAct=EBI-747430, EBI-722343; CC Q9BXK5; O75379-2: VAMP4; NbExp=3; IntAct=EBI-747430, EBI-10187996; CC Q9BXK5; O76024: WFS1; NbExp=3; IntAct=EBI-747430, EBI-720609; CC Q9BXK5; B2R9H7; NbExp=3; IntAct=EBI-747430, EBI-10175711; CC Q9BXK5; Q5ZSD5: sidF; Xeno; NbExp=7; IntAct=EBI-747430, EBI-15625247; CC -!- SUBCELLULAR LOCATION: [Isoform 2]: Mitochondrion membrane CC {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. Nucleus CC {ECO:0000305}. CC -!- SUBCELLULAR LOCATION: [Isoform 1]: Nucleus {ECO:0000305}. CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=3; CC Comment=Experimental confirmation may be lacking for some isoforms.; CC Name=2; CC IsoId=Q9BXK5-1; Sequence=Displayed; CC Name=1; CC IsoId=Q9BXK5-2; Sequence=VSP_000526, VSP_000527; CC Name=3; CC IsoId=Q9BXK5-4; Sequence=VSP_046931; CC -!- TISSUE SPECIFICITY: Ubiquitous, with the highest levels of expression CC in heart, placenta and pancreas. CC -!- SIMILARITY: Belongs to the Bcl-2 family. {ECO:0000305}. CC -!- SEQUENCE CAUTION: CC Sequence=AAF03602.1; Type=Erroneous initiation; Evidence={ECO:0000305}; CC Sequence=AAG09680.1; Type=Frameshift; Evidence={ECO:0000305}; CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AF325209; AAK27358.1; -; mRNA. DR EMBL; AF246665; AAK15150.1; -; mRNA. DR EMBL; AF183411; AAG09680.1; ALT_FRAME; mRNA. DR EMBL; CR456521; CAG30407.1; -; mRNA. DR EMBL; AK056248; BAG51659.1; -; mRNA. DR EMBL; AC006285; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; BC007658; AAH07658.1; -; mRNA. DR EMBL; BC016037; AAH16037.1; -; mRNA. DR EMBL; AF146568; AAF03602.1; ALT_INIT; mRNA. DR EMBL; AL133029; CAB61361.1; -; mRNA. DR CCDS; CCDS13746.1; -. [Q9BXK5-1] DR CCDS; CCDS59448.1; -. [Q9BXK5-4] DR CCDS; CCDS86995.1; -. [Q9BXK5-2] DR PIR; T42703; T42703. DR RefSeq; NP_001257658.1; NM_001270729.1. [Q9BXK5-4] DR RefSeq; NP_001257659.1; NM_001270730.1. [Q9BXK5-4] DR RefSeq; NP_001257660.1; NM_001270731.1. [Q9BXK5-4] DR RefSeq; NP_056182.2; NM_015367.3. [Q9BXK5-1] DR RefSeq; XP_011544423.1; XM_011546121.2. DR RefSeq; XP_016884217.1; XM_017028728.1. DR RefSeq; XP_016884218.1; XM_017028729.1. DR RefSeq; XP_016884219.1; XM_017028730.1. DR RefSeq; XP_016884220.1; XM_017028731.1. DR RefSeq; XP_016884221.1; XM_017028732.1. DR RefSeq; XP_016884222.1; XM_017028733.1. DR AlphaFoldDB; Q9BXK5; -. DR BioGRID; 117285; 148. DR DIP; DIP-60895N; -. DR IntAct; Q9BXK5; 94. DR MINT; Q9BXK5; -. DR STRING; 9606.ENSP00000480836; -. DR GlyGen; Q9BXK5; 1 site, 1 O-linked glycan (1 site). DR iPTMnet; Q9BXK5; -. DR PhosphoSitePlus; Q9BXK5; -. DR SwissPalm; Q9BXK5; -. DR BioMuta; BCL2L13; -. DR DMDM; 23396740; -. DR EPD; Q9BXK5; -. DR jPOST; Q9BXK5; -. DR MassIVE; Q9BXK5; -. DR MaxQB; Q9BXK5; -. DR PaxDb; 9606-ENSP00000480836; -. DR PeptideAtlas; Q9BXK5; -. DR ProteomicsDB; 3529; -. DR ProteomicsDB; 79446; -. [Q9BXK5-1] DR ProteomicsDB; 79447; -. [Q9BXK5-2] DR Pumba; Q9BXK5; -. DR Antibodypedia; 3673; 299 antibodies from 35 providers. DR DNASU; 23786; -. DR Ensembl; ENST00000317582.10; ENSP00000318883.5; ENSG00000099968.18. [Q9BXK5-1] DR Ensembl; ENST00000399782.5; ENSP00000382682.1; ENSG00000099968.18. [Q9BXK5-2] DR Ensembl; ENST00000418951.6; ENSP00000410019.3; ENSG00000099968.18. [Q9BXK5-4] DR Ensembl; ENST00000493680.5; ENSP00000434764.1; ENSG00000099968.18. [Q9BXK5-2] DR Ensembl; ENST00000543133.5; ENSP00000437667.1; ENSG00000099968.18. [Q9BXK5-4] DR GeneID; 23786; -. DR KEGG; hsa:23786; -. DR MANE-Select; ENST00000317582.10; ENSP00000318883.5; NM_015367.4; NP_056182.2. DR UCSC; uc002zmu.4; human. [Q9BXK5-1] DR AGR; HGNC:17164; -. DR CTD; 23786; -. DR DisGeNET; 23786; -. DR GeneCards; BCL2L13; -. DR HGNC; HGNC:17164; BCL2L13. DR HPA; ENSG00000099968; Tissue enhanced (skeletal). DR MIM; 619822; gene. DR neXtProt; NX_Q9BXK5; -. DR OpenTargets; ENSG00000099968; -. DR PharmGKB; PA134912159; -. DR VEuPathDB; HostDB:ENSG00000099968; -. DR eggNOG; ENOG502R6AP; Eukaryota. DR GeneTree; ENSGT00390000015552; -. DR HOGENOM; CLU_032647_2_0_1; -. DR InParanoid; Q9BXK5; -. DR OMA; MHEALQT; -. DR OrthoDB; 5399330at2759; -. DR PhylomeDB; Q9BXK5; -. DR TreeFam; TF330744; -. DR PathwayCommons; Q9BXK5; -. DR SignaLink; Q9BXK5; -. DR BioGRID-ORCS; 23786; 17 hits in 1170 CRISPR screens. DR ChiTaRS; BCL2L13; human. DR GeneWiki; BCL2L13; -. DR GenomeRNAi; 23786; -. DR Pharos; Q9BXK5; Tbio. DR PRO; PR:Q9BXK5; -. DR Proteomes; UP000005640; Chromosome 22. DR RNAct; Q9BXK5; Protein. DR Bgee; ENSG00000099968; Expressed in secondary oocyte and 205 other cell types or tissues. DR ExpressionAtlas; Q9BXK5; baseline and differential. DR GO; GO:0016020; C:membrane; IDA:UniProtKB. DR GO; GO:0031966; C:mitochondrial membrane; IEA:UniProtKB-SubCell. DR GO; GO:0005739; C:mitochondrion; NAS:UniProtKB. DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. DR GO; GO:0008656; F:cysteine-type endopeptidase activator activity involved in apoptotic process; NAS:UniProtKB. DR GO; GO:0006919; P:activation of cysteine-type endopeptidase activity involved in apoptotic process; NAS:UniProtKB. DR GO; GO:0006915; P:apoptotic process; NAS:UniProtKB. DR GO; GO:0042981; P:regulation of apoptotic process; IEA:InterPro. DR Gene3D; 1.10.437.10; Blc2-like; 1. DR InterPro; IPR036834; Bcl-2-like_sf. DR InterPro; IPR046371; Bcl-2_BH1-3. DR InterPro; IPR002475; Bcl2-like. DR InterPro; IPR042398; BCL2L13. DR PANTHER; PTHR15758; BCL-2-LIKE PROTEIN 13; 1. DR PANTHER; PTHR15758:SF2; BCL-2-LIKE PROTEIN 13; 1. DR Pfam; PF00452; Bcl-2; 1. DR SUPFAM; SSF56854; Bcl-2 inhibitors of programmed cell death; 1. DR PROSITE; PS50062; BCL2_FAMILY; 1. DR Genevisible; Q9BXK5; HS. PE 1: Evidence at protein level; KW Alternative splicing; Apoptosis; Membrane; Mitochondrion; Nucleus; KW Phosphoprotein; Reference proteome; Repeat; Transmembrane; KW Transmembrane helix. FT CHAIN 1..485 FT /note="Bcl-2-like protein 13" FT /id="PRO_0000143073" FT TRANSMEM 460..480 FT /note="Helical" FT /evidence="ECO:0000255" FT REPEAT 246..256 FT /note="A" FT REPEAT 261..271 FT /note="A; approximate" FT REPEAT 425..441 FT /note="B" FT REPEAT 443..459 FT /note="B; approximate" FT REGION 218..248 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 418..451 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT MOTIF 14..30 FT /note="BH4" FT MOTIF 100..116 FT /note="BH3" FT MOTIF 147..157 FT /note="BH1" FT MOTIF 193..206 FT /note="BH2" FT COMPBIAS 224..248 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT MOD_RES 38 FT /note="Phosphoserine" FT /evidence="ECO:0007744|PubMed:18669648" FT MOD_RES 259 FT /note="Phosphoserine" FT /evidence="ECO:0007744|PubMed:24275569" FT MOD_RES 261 FT /note="Phosphoserine" FT /evidence="ECO:0007744|PubMed:24275569" FT MOD_RES 303 FT /note="Phosphoserine" FT /evidence="ECO:0007744|PubMed:23186163" FT MOD_RES 326 FT /note="Phosphoserine" FT /evidence="ECO:0007744|PubMed:24275569" FT MOD_RES 371 FT /note="Phosphoserine" FT /evidence="ECO:0000250|UniProtKB:P59017" FT MOD_RES 375 FT /note="Phosphoserine" FT /evidence="ECO:0000250|UniProtKB:P59017" FT MOD_RES 410 FT /note="Phosphoserine" FT /evidence="ECO:0007744|PubMed:24275569" FT MOD_RES 420 FT /note="Phosphoserine" FT /evidence="ECO:0007744|PubMed:18669648, FT ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, FT ECO:0007744|PubMed:23186163" FT MOD_RES 426 FT /note="Phosphoserine" FT /evidence="ECO:0007744|PubMed:18669648, FT ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, FT ECO:0007744|PubMed:23186163" FT MOD_RES 429 FT /note="Phosphoserine" FT /evidence="ECO:0007744|PubMed:20068231" FT MOD_RES 444 FT /note="Phosphoserine" FT /evidence="ECO:0007744|PubMed:23186163" FT VAR_SEQ 1..162 FT /note="Missing (in isoform 3)" FT /evidence="ECO:0000303|PubMed:14702039" FT /id="VSP_046931" FT VAR_SEQ 201 FT /note="G -> V (in isoform 1)" FT /evidence="ECO:0000303|PubMed:11381032, FT ECO:0000303|PubMed:15461802, ECO:0000303|Ref.3" FT /id="VSP_000526" FT VAR_SEQ 202..485 FT /note="Missing (in isoform 1)" FT /evidence="ECO:0000303|PubMed:11381032, FT ECO:0000303|PubMed:15461802, ECO:0000303|Ref.3" FT /id="VSP_000527" FT VARIANT 46 FT /note="I -> R (in dbSNP:rs2587070)" FT /evidence="ECO:0007744|PubMed:18669648" FT /id="VAR_059141" FT VARIANT 46 FT /note="I -> T (in dbSNP:rs2587070)" FT /id="VAR_059142" FT VARIANT 55 FT /note="I -> V (in dbSNP:rs16981016)" FT /id="VAR_024377" FT VARIANT 360 FT /note="P -> S (in dbSNP:rs9306198)" FT /evidence="ECO:0000269|PubMed:15489334" FT /id="VAR_024378" FT CONFLICT 170 FT /note="R -> L (in Ref. 8; AAF03602)" FT /evidence="ECO:0000305" FT CONFLICT 391 FT /note="E -> Q (in Ref. 9; CAB61361)" FT /evidence="ECO:0000305" SQ SEQUENCE 485 AA; 52723 MW; D9404665111B6CE0 CRC64; MASSSTVPLG FHYETKYVVL SYLGLLSQEK LQEQHLSSPQ GVQLDIASQS LDQEILLKVK TEIEEELKSL DKEISEAFTS TGFDRHTSPV FSPANPESSM EDCLAHLGEK VSQELKEPLH KALQMLLSQP VTYQAFRECT LETTVHASGW NKILVPLVLL RQMLLELTRR GQEPLSALLQ FGVTYLEDYS AEYIIQQGGW GTVFSLESEE EEYPGITAED SNDIYILPSD NSGQVSPPES PTVTTSWQSE SLPVSLSASQ SWHTESLPVS LGPESWQQIA MDPEEVKSLD SNGAGEKSEN NSSNSDIVHV EKEEVPEGME EAAVASVVLP ARELQEALPE APAPLLPHIT ATSLLGTREP DTEVITVEKS SPATSLFVEL DEEEVKAATT EPTEVEEVVP ALEPTETLLS EKEINAREES LVEELSPASE KKPVPPSEGK SRLSPAGEMK PMPLSEGKSI LLFGGAAAVA ILAVAIGVAL ALRKK //