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Protein

Bcl-2-like protein 13

Gene

BCL2L13

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May promote the activation of caspase-3 and apoptosis.

GO - Molecular functioni

  • cysteine-type endopeptidase activator activity involved in apoptotic process Source: UniProtKB

GO - Biological processi

  • activation of cysteine-type endopeptidase activity involved in apoptotic process Source: UniProtKB
  • apoptotic process Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Apoptosis

Enzyme and pathway databases

BioCyciZFISH:ENSG00000099968-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Bcl-2-like protein 13
Short name:
Bcl2-L-13
Alternative name(s):
Bcl-rambo
Protein Mil1
Gene namesi
Name:BCL2L13
Synonyms:MIL1
ORF Names:CD003
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

HGNCiHGNC:17164. BCL2L13.

Subcellular locationi

Isoform 1 :

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei460 – 480HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB
  • mitochondrial membrane Source: UniProtKB-SubCell
  • mitochondrion Source: UniProtKB
  • nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi23786.
OpenTargetsiENSG00000099968.
PharmGKBiPA134912159.

Polymorphism and mutation databases

DMDMi23396740.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001430731 – 485Bcl-2-like protein 13Add BLAST485

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei38PhosphoserineCombined sources1
Modified residuei259PhosphoserineCombined sources1
Modified residuei261PhosphoserineCombined sources1
Modified residuei303PhosphoserineCombined sources1
Modified residuei326PhosphoserineCombined sources1
Modified residuei371PhosphoserineBy similarity1
Modified residuei375PhosphoserineBy similarity1
Modified residuei410PhosphoserineCombined sources1
Modified residuei420PhosphoserineCombined sources1
Modified residuei426PhosphoserineCombined sources1
Modified residuei429PhosphoserineCombined sources1
Modified residuei444PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9BXK5.
MaxQBiQ9BXK5.
PaxDbiQ9BXK5.
PeptideAtlasiQ9BXK5.
PRIDEiQ9BXK5.

PTM databases

iPTMnetiQ9BXK5.
PhosphoSitePlusiQ9BXK5.
SwissPalmiQ9BXK5.

Expressioni

Tissue specificityi

Ubiquitous, with the highest levels of expression in heart, placenta and pancreas.

Gene expression databases

BgeeiENSG00000099968.
CleanExiHS_BCL2L13.
ExpressionAtlasiQ9BXK5. baseline and differential.
GenevisibleiQ9BXK5. HS.

Organism-specific databases

HPAiCAB002052.
HPA030994.
HPA050377.

Interactioni

Subunit structurei

Monomer.Curated

Binary interactionsi

WithEntry#Exp.IntActNotes
B2R9H73EBI-747430,EBI-10175711
BET1Q53XK03EBI-747430,EBI-10242927
GABARAPL2P605204EBI-747430,EBI-720116
NINJ2Q9NZG73EBI-747430,EBI-10317425
PLLPQ9Y3423EBI-747430,EBI-3919291
TMEM128Q5BJH23EBI-747430,EBI-10243515
TMEM86BQ8N6613EBI-747430,EBI-2548832
TMUB2Q71RG43EBI-747430,EBI-2820477
VAMP3Q158363EBI-747430,EBI-722343
VAMP4O75379-23EBI-747430,EBI-10187996

Protein-protein interaction databases

BioGridi117285. 13 interactors.
DIPiDIP-60895N.
IntActiQ9BXK5. 28 interactors.
MINTiMINT-4538648.
STRINGi9606.ENSP00000318883.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2IPDmodel-@1-485[»]
ProteinModelPortaliQ9BXK5.
SMRiQ9BXK5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati246 – 256AAdd BLAST11
Repeati261 – 271A; approximateAdd BLAST11
Repeati425 – 441BAdd BLAST17
Repeati443 – 459B; approximateAdd BLAST17

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi14 – 30BH4Add BLAST17
Motifi100 – 116BH3Add BLAST17
Motifi147 – 157BH1Add BLAST11
Motifi193 – 206BH2Add BLAST14

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi207 – 212Poly-Glu6
Compositional biasi311 – 424Glu-richAdd BLAST114

Sequence similaritiesi

Belongs to the Bcl-2 family.Curated

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IK4J. Eukaryota.
ENOG410XT6A. LUCA.
GeneTreeiENSGT00390000015552.
HOGENOMiHOG000059276.
HOVERGENiHBG050648.
InParanoidiQ9BXK5.
KOiK15485.
PhylomeDBiQ9BXK5.
TreeFamiTF330744.

Family and domain databases

InterProiIPR002475. Bcl2-like.
IPR026298. Blc2_fam.
[Graphical view]
PfamiPF00452. Bcl-2. 1 hit.
[Graphical view]
PROSITEiPS50062. BCL2_FAMILY. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Note: Experimental confirmation may be lacking for some isoforms.
Isoform 2 (identifier: Q9BXK5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MASSSTVPLG FHYETKYVVL SYLGLLSQEK LQEQHLSSPQ GVQLDIASQS
60 70 80 90 100
LDQEILLKVK TEIEEELKSL DKEISEAFTS TGFDRHTSPV FSPANPESSM
110 120 130 140 150
EDCLAHLGEK VSQELKEPLH KALQMLLSQP VTYQAFRECT LETTVHASGW
160 170 180 190 200
NKILVPLVLL RQMLLELTRR GQEPLSALLQ FGVTYLEDYS AEYIIQQGGW
210 220 230 240 250
GTVFSLESEE EEYPGITAED SNDIYILPSD NSGQVSPPES PTVTTSWQSE
260 270 280 290 300
SLPVSLSASQ SWHTESLPVS LGPESWQQIA MDPEEVKSLD SNGAGEKSEN
310 320 330 340 350
NSSNSDIVHV EKEEVPEGME EAAVASVVLP ARELQEALPE APAPLLPHIT
360 370 380 390 400
ATSLLGTREP DTEVITVEKS SPATSLFVEL DEEEVKAATT EPTEVEEVVP
410 420 430 440 450
ALEPTETLLS EKEINAREES LVEELSPASE KKPVPPSEGK SRLSPAGEMK
460 470 480
PMPLSEGKSI LLFGGAAAVA ILAVAIGVAL ALRKK
Length:485
Mass (Da):52,723
Last modified:June 1, 2001 - v1
Checksum:iD9404665111B6CE0
GO
Isoform 1 (identifier: Q9BXK5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     201-201: G → V
     202-485: Missing.

Show »
Length:201
Mass (Da):22,612
Checksum:iC343D4873BCC2A91
GO
Isoform 3 (identifier: Q9BXK5-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-162: Missing.

Show »
Length:323
Mass (Da):34,601
Checksum:i77A9CADD907ED1F9
GO

Sequence cautioni

The sequence AAF03602 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAG09680 differs from that shown. Reason: Frameshift at several positions.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti170R → L in AAF03602 (Ref. 8) Curated1
Sequence conflicti391E → Q in CAB61361 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05914146I → R.Combined sourcesCorresponds to variant rs2587070dbSNPEnsembl.1
Natural variantiVAR_05914246I → T.Corresponds to variant rs2587070dbSNPEnsembl.1
Natural variantiVAR_02437755I → V.Corresponds to variant rs16981016dbSNPEnsembl.1
Natural variantiVAR_024378360P → S.1 PublicationCorresponds to variant rs9306198dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0469311 – 162Missing in isoform 3. 1 PublicationAdd BLAST162
Alternative sequenceiVSP_000526201G → V in isoform 1. 3 Publications1
Alternative sequenceiVSP_000527202 – 485Missing in isoform 1. 3 PublicationsAdd BLAST284

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF325209 mRNA. Translation: AAK27358.1.
AF246665 mRNA. Translation: AAK15150.1.
AF183411 mRNA. Translation: AAG09680.1. Frameshift.
CR456521 mRNA. Translation: CAG30407.1.
AK056248 mRNA. Translation: BAG51659.1.
AC006285 Genomic DNA. No translation available.
BC007658 mRNA. Translation: AAH07658.1.
BC016037 mRNA. Translation: AAH16037.1.
AF146568 mRNA. Translation: AAF03602.1. Different initiation.
AL133029 mRNA. Translation: CAB61361.1.
CCDSiCCDS13746.1. [Q9BXK5-1]
CCDS59448.1. [Q9BXK5-4]
PIRiT42703.
RefSeqiNP_001257658.1. NM_001270729.1. [Q9BXK5-4]
NP_001257659.1. NM_001270730.1. [Q9BXK5-4]
NP_001257660.1. NM_001270731.1. [Q9BXK5-4]
NP_056182.2. NM_015367.3. [Q9BXK5-1]
XP_011544423.1. XM_011546121.2. [Q9BXK5-1]
XP_016884217.1. XM_017028728.1. [Q9BXK5-4]
XP_016884218.1. XM_017028729.1. [Q9BXK5-4]
XP_016884219.1. XM_017028730.1. [Q9BXK5-4]
XP_016884220.1. XM_017028731.1. [Q9BXK5-4]
XP_016884221.1. XM_017028732.1. [Q9BXK5-4]
XP_016884222.1. XM_017028733.1. [Q9BXK5-2]
UniGeneiHs.631672.

Genome annotation databases

EnsembliENST00000317582; ENSP00000318883; ENSG00000099968. [Q9BXK5-1]
ENST00000399782; ENSP00000382682; ENSG00000099968. [Q9BXK5-2]
ENST00000418951; ENSP00000410019; ENSG00000099968. [Q9BXK5-4]
ENST00000493680; ENSP00000434764; ENSG00000099968. [Q9BXK5-2]
ENST00000543133; ENSP00000437667; ENSG00000099968. [Q9BXK5-4]
GeneIDi23786.
KEGGihsa:23786.
UCSCiuc002zmu.4. human. [Q9BXK5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF325209 mRNA. Translation: AAK27358.1.
AF246665 mRNA. Translation: AAK15150.1.
AF183411 mRNA. Translation: AAG09680.1. Frameshift.
CR456521 mRNA. Translation: CAG30407.1.
AK056248 mRNA. Translation: BAG51659.1.
AC006285 Genomic DNA. No translation available.
BC007658 mRNA. Translation: AAH07658.1.
BC016037 mRNA. Translation: AAH16037.1.
AF146568 mRNA. Translation: AAF03602.1. Different initiation.
AL133029 mRNA. Translation: CAB61361.1.
CCDSiCCDS13746.1. [Q9BXK5-1]
CCDS59448.1. [Q9BXK5-4]
PIRiT42703.
RefSeqiNP_001257658.1. NM_001270729.1. [Q9BXK5-4]
NP_001257659.1. NM_001270730.1. [Q9BXK5-4]
NP_001257660.1. NM_001270731.1. [Q9BXK5-4]
NP_056182.2. NM_015367.3. [Q9BXK5-1]
XP_011544423.1. XM_011546121.2. [Q9BXK5-1]
XP_016884217.1. XM_017028728.1. [Q9BXK5-4]
XP_016884218.1. XM_017028729.1. [Q9BXK5-4]
XP_016884219.1. XM_017028730.1. [Q9BXK5-4]
XP_016884220.1. XM_017028731.1. [Q9BXK5-4]
XP_016884221.1. XM_017028732.1. [Q9BXK5-4]
XP_016884222.1. XM_017028733.1. [Q9BXK5-2]
UniGeneiHs.631672.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2IPDmodel-@1-485[»]
ProteinModelPortaliQ9BXK5.
SMRiQ9BXK5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117285. 13 interactors.
DIPiDIP-60895N.
IntActiQ9BXK5. 28 interactors.
MINTiMINT-4538648.
STRINGi9606.ENSP00000318883.

PTM databases

iPTMnetiQ9BXK5.
PhosphoSitePlusiQ9BXK5.
SwissPalmiQ9BXK5.

Polymorphism and mutation databases

DMDMi23396740.

Proteomic databases

EPDiQ9BXK5.
MaxQBiQ9BXK5.
PaxDbiQ9BXK5.
PeptideAtlasiQ9BXK5.
PRIDEiQ9BXK5.

Protocols and materials databases

DNASUi23786.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000317582; ENSP00000318883; ENSG00000099968. [Q9BXK5-1]
ENST00000399782; ENSP00000382682; ENSG00000099968. [Q9BXK5-2]
ENST00000418951; ENSP00000410019; ENSG00000099968. [Q9BXK5-4]
ENST00000493680; ENSP00000434764; ENSG00000099968. [Q9BXK5-2]
ENST00000543133; ENSP00000437667; ENSG00000099968. [Q9BXK5-4]
GeneIDi23786.
KEGGihsa:23786.
UCSCiuc002zmu.4. human. [Q9BXK5-1]

Organism-specific databases

CTDi23786.
DisGeNETi23786.
GeneCardsiBCL2L13.
HGNCiHGNC:17164. BCL2L13.
HPAiCAB002052.
HPA030994.
HPA050377.
neXtProtiNX_Q9BXK5.
OpenTargetsiENSG00000099968.
PharmGKBiPA134912159.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IK4J. Eukaryota.
ENOG410XT6A. LUCA.
GeneTreeiENSGT00390000015552.
HOGENOMiHOG000059276.
HOVERGENiHBG050648.
InParanoidiQ9BXK5.
KOiK15485.
PhylomeDBiQ9BXK5.
TreeFamiTF330744.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000099968-MONOMER.

Miscellaneous databases

ChiTaRSiBCL2L13. human.
GeneWikiiBCL2L13.
GenomeRNAii23786.
PROiQ9BXK5.

Gene expression databases

BgeeiENSG00000099968.
CleanExiHS_BCL2L13.
ExpressionAtlasiQ9BXK5. baseline and differential.
GenevisibleiQ9BXK5. HS.

Family and domain databases

InterProiIPR002475. Bcl2-like.
IPR026298. Blc2_fam.
[Graphical view]
PfamiPF00452. Bcl-2. 1 hit.
[Graphical view]
PROSITEiPS50062. BCL2_FAMILY. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiB2L13_HUMAN
AccessioniPrimary (citable) accession number: Q9BXK5
Secondary accession number(s): B3KPE7
, Q96B37, Q96IB7, Q9BY01, Q9HC05, Q9UFE0, Q9UKN3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: June 1, 2001
Last modified: November 30, 2016
This is version 151 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.