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Protein

Krueppel-like factor 16

Gene

KLF16

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Transcription factor that binds GC and GT boxes and displaces Sp1 and Sp3 from these sequences. Modulates dopaminergic transmission in the brain (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri127 – 150C2H2-type 1PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri157 – 181C2H2-type 2PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri187 – 209C2H2-type 3PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

SIGNORiQ9BXK1.

Names & Taxonomyi

Protein namesi
Recommended name:
Krueppel-like factor 16
Alternative name(s):
Basic transcription element-binding protein 4
Short name:
BTE-binding protein 4
Novel Sp1-like zinc finger transcription factor 2
Transcription factor BTEB4
Transcription factor NSLP2
Gene namesi
Name:KLF16
Synonyms:BTEB4, NSLP2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:16857. KLF16.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi83855.
OpenTargetsiENSG00000129911.
PharmGKBiPA30135.

Polymorphism and mutation databases

BioMutaiKLF16.
DMDMi17366682.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000471581 – 252Krueppel-like factor 16Add BLAST252

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei99PhosphoserineCombined sources1
Modified residuei152PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9BXK1.
MaxQBiQ9BXK1.
PaxDbiQ9BXK1.
PeptideAtlasiQ9BXK1.
PRIDEiQ9BXK1.

PTM databases

iPTMnetiQ9BXK1.
PhosphoSitePlusiQ9BXK1.

Expressioni

Gene expression databases

BgeeiENSG00000129911.
CleanExiHS_KLF16.
ExpressionAtlasiQ9BXK1. baseline and differential.
GenevisibleiQ9BXK1. HS.

Organism-specific databases

HPAiHPA052481.

Interactioni

Protein-protein interaction databases

BioGridi123771. 26 interactors.
IntActiQ9BXK1. 22 interactors.
MINTiMINT-8330014.
STRINGi9606.ENSP00000250916.

Structurei

3D structure databases

ProteinModelPortaliQ9BXK1.
SMRiQ9BXK1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi3 – 130Ala/Pro-richAdd BLAST128
Compositional biasi99 – 112Ser-richAdd BLAST14
Compositional biasi210 – 249Pro/Ser-richAdd BLAST40

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri127 – 150C2H2-type 1PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri157 – 181C2H2-type 2PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri187 – 209C2H2-type 3PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00760000118984.
HOGENOMiHOG000233575.
HOVERGENiHBG050746.
InParanoidiQ9BXK1.
KOiK09208.
OMAiPMSAYSE.
OrthoDBiEOG091G1BN0.
PhylomeDBiQ9BXK1.
TreeFamiTF351003.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiView protein in InterPro
IPR013087. Znf_C2H2_type.
IPR013083. Znf_RING/FYVE/PHD.
SMARTiView protein in SMART
SM00355. ZnF_C2H2. 3 hits.
SUPFAMiSSF57667. SSF57667. 2 hits.
PROSITEiView protein in PROSITE
PS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 3 hits.

Sequencei

Sequence statusi: Complete.

Q9BXK1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAAVACVDY FAADVLMAIS SGAVVHRGRP GPEGAGPAAG LDVRAARREA
60 70 80 90 100
ASPGTPGPPP PPPAASGPGP GAAAAPHLLA ASILADLRGG PGAAPGGASP
110 120 130 140 150
ASSSSAASSP SSGRAPGAAP SAAAKSHRCP FPDCAKAYYK SSHLKSHLRT
160 170 180 190 200
HTGERPFACD WQGCDKKFAR SDELARHHRT HTGEKRFSCP LCSKRFTRSD
210 220 230 240 250
HLAKHARRHP GFHPDLLRRP GARSTSPSDS LPCSLAGSPA PSPAPSPAPA

GL
Length:252
Mass (Da):25,431
Last modified:June 1, 2001 - v1
Checksum:i9A0CB4B1A585A118
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF327440 mRNA. Translation: AAK15698.1.
CCDSiCCDS12075.1.
RefSeqiNP_114124.1. NM_031918.3.
UniGeneiHs.136280.

Genome annotation databases

EnsembliENST00000250916; ENSP00000250916; ENSG00000129911.
ENST00000541015; ENSP00000439973; ENSG00000129911.
ENST00000617223; ENSP00000483701; ENSG00000129911.
GeneIDi83855.
KEGGihsa:83855.
UCSCiuc002luc.4. human.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiKLF16_HUMAN
AccessioniPrimary (citable) accession number: Q9BXK1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 2, 2001
Last sequence update: June 1, 2001
Last modified: June 7, 2017
This is version 134 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families