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Protein

Krueppel-like factor 16

Gene

KLF16

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcription factor that binds GC and GT boxes and displaces Sp1 and Sp3 from these sequences. Modulates dopaminergic transmission in the brain (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri127 – 150C2H2-type 1PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri157 – 181C2H2-type 2PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri187 – 209C2H2-type 3PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

SIGNORiQ9BXK1

Names & Taxonomyi

Protein namesi
Recommended name:
Krueppel-like factor 16
Alternative name(s):
Basic transcription element-binding protein 4
Short name:
BTE-binding protein 4
Novel Sp1-like zinc finger transcription factor 2
Transcription factor BTEB4
Transcription factor NSLP2
Gene namesi
Name:KLF16
Synonyms:BTEB4, NSLP2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000129911.8
HGNCiHGNC:16857 KLF16
MIMi606139 gene
neXtProtiNX_Q9BXK1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi83855
OpenTargetsiENSG00000129911
PharmGKBiPA30135

Polymorphism and mutation databases

BioMutaiKLF16
DMDMi17366682

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000471581 – 252Krueppel-like factor 16Add BLAST252

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei99PhosphoserineCombined sources1
Modified residuei152PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9BXK1
MaxQBiQ9BXK1
PaxDbiQ9BXK1
PeptideAtlasiQ9BXK1
PRIDEiQ9BXK1

PTM databases

iPTMnetiQ9BXK1
PhosphoSitePlusiQ9BXK1

Expressioni

Gene expression databases

BgeeiENSG00000129911
CleanExiHS_KLF16
ExpressionAtlasiQ9BXK1 baseline and differential
GenevisibleiQ9BXK1 HS

Organism-specific databases

HPAiHPA052481

Interactioni

Protein-protein interaction databases

BioGridi123771, 27 interactors
ELMiQ9BXK1
IntActiQ9BXK1, 22 interactors
MINTiQ9BXK1
STRINGi9606.ENSP00000250916

Structurei

3D structure databases

ProteinModelPortaliQ9BXK1
SMRiQ9BXK1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi3 – 130Ala/Pro-richAdd BLAST128
Compositional biasi99 – 112Ser-richAdd BLAST14
Compositional biasi210 – 249Pro/Ser-richAdd BLAST40

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri127 – 150C2H2-type 1PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri157 – 181C2H2-type 2PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri187 – 209C2H2-type 3PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00760000118984
HOGENOMiHOG000233575
HOVERGENiHBG050746
InParanoidiQ9BXK1
KOiK09208
OMAiPMSAYSE
OrthoDBiEOG091G1BN0
PhylomeDBiQ9BXK1
TreeFamiTF351003

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 3 hits
SUPFAMiSSF57667 SSF57667, 2 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 3 hits
PS50157 ZINC_FINGER_C2H2_2, 3 hits

Sequencei

Sequence statusi: Complete.

Q9BXK1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAAVACVDY FAADVLMAIS SGAVVHRGRP GPEGAGPAAG LDVRAARREA
60 70 80 90 100
ASPGTPGPPP PPPAASGPGP GAAAAPHLLA ASILADLRGG PGAAPGGASP
110 120 130 140 150
ASSSSAASSP SSGRAPGAAP SAAAKSHRCP FPDCAKAYYK SSHLKSHLRT
160 170 180 190 200
HTGERPFACD WQGCDKKFAR SDELARHHRT HTGEKRFSCP LCSKRFTRSD
210 220 230 240 250
HLAKHARRHP GFHPDLLRRP GARSTSPSDS LPCSLAGSPA PSPAPSPAPA

GL
Length:252
Mass (Da):25,431
Last modified:June 1, 2001 - v1
Checksum:i9A0CB4B1A585A118
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF327440 mRNA Translation: AAK15698.1
CCDSiCCDS12075.1
RefSeqiNP_114124.1, NM_031918.3
UniGeneiHs.136280

Genome annotation databases

EnsembliENST00000250916; ENSP00000250916; ENSG00000129911
ENST00000541015; ENSP00000439973; ENSG00000129911
ENST00000617223; ENSP00000483701; ENSG00000129911
GeneIDi83855
KEGGihsa:83855
UCSCiuc002luc.4 human

Similar proteinsi

Entry informationi

Entry nameiKLF16_HUMAN
AccessioniPrimary (citable) accession number: Q9BXK1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 2, 2001
Last sequence update: June 1, 2001
Last modified: May 23, 2018
This is version 141 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

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