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Q9BXJ9

- NAA15_HUMAN

UniProt

Q9BXJ9 - NAA15_HUMAN

Protein

N-alpha-acetyltransferase 15, NatA auxiliary subunit

Gene

NAA15

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 126 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
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    Functioni

    Auxillary subunit of the N-terminal acetyltransferase A (NatA) complex which displays alpha (N-terminal) acetyltransferase activity. The NAT activity may be important for vascular, hematopoietic and neuronal growth and development. Required to control retinal neovascularization in adult ocular endothelial cells. In complex with XRCC6 and XRCC5 (Ku80), up-regulates transcription from the osteocalcin promoter.3 Publications

    GO - Molecular functioni

    1. N-acetyltransferase activity Source: Ensembl
    2. poly(A) RNA binding Source: UniProtKB
    3. protein binding Source: UniProtKB
    4. ribosome binding Source: UniProt

    GO - Biological processi

    1. angiogenesis Source: UniProtKB-KW
    2. cell differentiation Source: UniProtKB-KW
    3. negative regulation of apoptotic process Source: UniProt
    4. N-terminal protein amino acid acetylation Source: UniProtKB
    5. positive regulation of transcription, DNA-templated Source: UniProtKB
    6. protein stabilization Source: UniProt
    7. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Angiogenesis, Differentiation, Transcription, Transcription regulation

    Enzyme and pathway databases

    BRENDAi2.3.1.88. 2681.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    N-alpha-acetyltransferase 15, NatA auxiliary subunit
    Alternative name(s):
    Gastric cancer antigen Ga19
    N-terminal acetyltransferase
    NMDA receptor-regulated protein 1
    Protein tubedown-1
    Tbdn100
    Gene namesi
    Name:NAA15
    Synonyms:GA19, NARG1, NATH, TBDN100
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 4

    Organism-specific databases

    HGNCiHGNC:30782. NAA15.

    Subcellular locationi

    Cytoplasm. Nucleus
    Note: Mainly cytoplasmic, nuclear in some cases. Present in the free cytosolic and cytoskeleton-bound polysomes, but not in the membrane-bound polysomes.

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB
    2. membrane Source: UniProtKB
    3. NatA complex Source: UniProtKB
    4. nucleus Source: UniProtKB
    5. transcription factor complex Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA165664293.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 866866N-alpha-acetyltransferase 15, NatA auxiliary subunitPRO_0000106294Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei262 – 2621N6-acetyllysine1 Publication
    Modified residuei399 – 3991Phosphothreonine1 Publication
    Modified residuei403 – 4031Phosphoserine1 Publication
    Modified residuei588 – 5881Phosphoserine1 Publication
    Modified residuei735 – 7351N6-acetyllysine1 Publication
    Modified residuei756 – 7561N6-acetyllysine1 Publication
    Modified residuei855 – 8551PhosphoserineBy similarity
    Modified residuei856 – 8561Phosphoserine2 Publications

    Post-translational modificationi

    Cleaved by caspases during apoptosis, resulting in a stable 35 kDa fragment.

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiQ9BXJ9.
    PaxDbiQ9BXJ9.
    PRIDEiQ9BXJ9.

    PTM databases

    PhosphoSiteiQ9BXJ9.

    Expressioni

    Tissue specificityi

    Expressed at high levels in testis and in ocular endothelial cells. Also found in brain (corpus callosum), heart, colon, bone marrow and at lower levels in most adult tissues, including thyroid, liver, pancreas, mammary and salivary glands, lung, ovary, urogenital system and upper gastrointestinal tract. Overexpressed in gastric cancer, in papillary thyroid carcinomas and in a Burkitt lymphoma cell line (Daudi). Specifically suppressed in abnormal proliferating blood vessels in eyes of patients with proliferative diabetic retinopathy.3 Publications

    Gene expression databases

    ArrayExpressiQ9BXJ9.
    BgeeiQ9BXJ9.
    CleanExiHS_NARG1.
    GenevestigatoriQ9BXJ9.

    Organism-specific databases

    HPAiHPA023589.
    HPA050661.

    Interactioni

    Subunit structurei

    Component of the N-terminal acetyltransferase A (NatA) complex composed of NAA10 or probably NAA11 and NAA15. Interacts with XRCC6, NAA50 and XRCC5. Associates with HYPK when in a complex with NAA10.5 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    NAA50Q9GZZ12EBI-1042540,EBI-1052523

    Protein-protein interaction databases

    BioGridi123146. 20 interactions.
    IntActiQ9BXJ9. 6 interactions.
    STRINGi9606.ENSP00000296543.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9BXJ9.
    SMRiQ9BXJ9. Positions 1-780.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati46 – 7934TPR 1Add
    BLAST
    Repeati80 – 11334TPR 2Add
    BLAST
    Repeati148 – 18437TPR 3Add
    BLAST
    Repeati224 – 25734TPR 4Add
    BLAST
    Repeati374 – 40734TPR 5Add
    BLAST
    Repeati409 – 44133TPR 6Add
    BLAST
    Repeati485 – 51834TPR 7Add
    BLAST
    Repeati672 – 70534TPR 8Add
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni500 – 866367Interaction with HYPKAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi612 – 62918Bipartite nuclear localization signalSequence AnalysisAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi629 – 6324Poly-Asp

    Sequence similaritiesi

    Contains 8 TPR repeats.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, TPR repeat

    Phylogenomic databases

    eggNOGiCOG0457.
    HOGENOMiHOG000191711.
    HOVERGENiHBG052576.
    InParanoidiQ9BXJ9.
    KOiK00670.
    OMAiYDSLPHR.
    OrthoDBiEOG747PKD.
    PhylomeDBiQ9BXJ9.
    TreeFamiTF106301.

    Family and domain databases

    Gene3Di1.25.40.10. 3 hits.
    InterProiIPR021183. NatA_aux_su.
    IPR013026. TPR-contain_dom.
    IPR011990. TPR-like_helical.
    IPR013105. TPR_2.
    IPR019734. TPR_repeat.
    [Graphical view]
    PfamiPF12569. NARP1. 1 hit.
    PF07719. TPR_2. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000422. N-terminal-AcTrfase-A_aux_su. 1 hit.
    SMARTiSM00028. TPR. 4 hits.
    [Graphical view]
    PROSITEiPS50005. TPR. 5 hits.
    PS50293. TPR_REGION. 2 hits.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9BXJ9-1) [UniParc]FASTAAdd to Basket

    Also known as: Long

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MPAVSLPPKE NALFKRILRC YEHKQYRNGL KFCKQILSNP KFAEHGETLA    50
    MKGLTLNCLG KKEEAYELVR RGLRNDLKSH VCWHVYGLLQ RSDKKYDEAI 100
    KCYRNALKWD KDNLQILRDL SLLQIQMRDL EGYRETRYQL LQLRPAQRAS 150
    WIGYAIAYHL LEDYEMAAKI LEEFRKTQQT SPDKVDYEYS ELLLYQNQVL 200
    REAGLYREAL EHLCTYEKQI CDKLAVEETK GELLLQLCRL EDAADVYRGL 250
    QERNPENWAY YKGLEKALKP ANMLERLKIY EEAWTKYPRG LVPRRLPLNF 300
    LSGEKFKECL DKFLRMNFSK GCPPVFNTLR SLYKDKEKVA IIEELVVGYE 350
    TSLKSCRLFN PNDDGKEEPP TTLLWVQYYL AQHYDKIGQP SIALEYINTA 400
    IESTPTLIEL FLVKAKIYKH AGNIKEAARW MDEAQALDTA DRFINSKCAK 450
    YMLKANLIKE AEEMCSKFTR EGTSAVENLN EMQCMWFQTE CAQAYKAMNK 500
    FGEALKKCHE IERHFIEITD DQFDFHTYCM RKITLRSYVD LLKLEDVLRQ 550
    HPFYFKAARI AIEIYLKLHD NPLTDENKEH EADTANMSDK ELKKLRNKQR 600
    RAQKKAQIEE EKKNAEKEKQ QRNQKKKKDD DDEEIGGPKE ELIPEKLAKV 650
    ETPLEEAIKF LTPLKNLVKN KIETHLFAFE IYFRKEKFLL MLQSVKRAFA 700
    IDSSHPWLHE CMIRLFNTAV CESKDLSDTV RTVLKQEMNR LFGATNPKNF 750
    NETFLKRNSD SLPHRLSAAK MVYYLDPSSQ KRAIELATTL DESLTNRNLQ 800
    TCMEVLEALY DGSLGDCKEA AEIYRANCHK LFPYALAFMP PGYEEDMKIT 850
    VNGDSSAEAE ELANEI 866
    Length:866
    Mass (Da):101,272
    Last modified:June 1, 2001 - v1
    Checksum:i6B4BA23B99D99121
    GO
    Isoform 2 (identifier: Q9BXJ9-4) [UniParc]FASTAAdd to Basket

    Also known as: Short

    The sequence of this isoform differs from the canonical sequence as follows:
         514-525: HFIEITDDQFDF → KSLMTSLTFIHTV
         526-866: Missing.

    Show »
    Length:526
    Mass (Da):61,602
    Checksum:i6C66BCE4B7377BB6
    GO

    Sequence cautioni

    The sequence AAH39818.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti425 – 4251K → R in AAM48746. (PubMed:12145306)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei514 – 52512HFIEI…DQFDF → KSLMTSLTFIHTV in isoform 2. 1 PublicationVSP_012560Add
    BLAST
    Alternative sequencei526 – 866341Missing in isoform 2. 1 PublicationVSP_012561Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY039242 mRNA. Translation: AAK68661.1.
    AY112670 mRNA. Translation: AAM48746.1.
    AJ314788 mRNA. Translation: CAC43228.1.
    AF327722 mRNA. Translation: AAK15707.1.
    AK023402 mRNA. Translation: BAB14562.1.
    AC097376 Genomic DNA. Translation: AAY40950.1.
    CH471056 Genomic DNA. Translation: EAX05119.1.
    BC039818 mRNA. Translation: AAH39818.1. Sequence problems.
    BC093928 mRNA. Translation: AAH93928.1.
    BC104806 mRNA. Translation: AAI04807.1.
    CCDSiCCDS43270.1. [Q9BXJ9-1]
    RefSeqiNP_476516.1. NM_057175.3. [Q9BXJ9-1]
    UniGeneiHs.745047.

    Genome annotation databases

    EnsembliENST00000296543; ENSP00000296543; ENSG00000164134. [Q9BXJ9-1]
    GeneIDi80155.
    KEGGihsa:80155.
    UCSCiuc003ihu.1. human. [Q9BXJ9-1]

    Polymorphism databases

    DMDMi57012969.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY039242 mRNA. Translation: AAK68661.1 .
    AY112670 mRNA. Translation: AAM48746.1 .
    AJ314788 mRNA. Translation: CAC43228.1 .
    AF327722 mRNA. Translation: AAK15707.1 .
    AK023402 mRNA. Translation: BAB14562.1 .
    AC097376 Genomic DNA. Translation: AAY40950.1 .
    CH471056 Genomic DNA. Translation: EAX05119.1 .
    BC039818 mRNA. Translation: AAH39818.1 . Sequence problems.
    BC093928 mRNA. Translation: AAH93928.1 .
    BC104806 mRNA. Translation: AAI04807.1 .
    CCDSi CCDS43270.1. [Q9BXJ9-1 ]
    RefSeqi NP_476516.1. NM_057175.3. [Q9BXJ9-1 ]
    UniGenei Hs.745047.

    3D structure databases

    ProteinModelPortali Q9BXJ9.
    SMRi Q9BXJ9. Positions 1-780.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 123146. 20 interactions.
    IntActi Q9BXJ9. 6 interactions.
    STRINGi 9606.ENSP00000296543.

    PTM databases

    PhosphoSitei Q9BXJ9.

    Polymorphism databases

    DMDMi 57012969.

    Proteomic databases

    MaxQBi Q9BXJ9.
    PaxDbi Q9BXJ9.
    PRIDEi Q9BXJ9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000296543 ; ENSP00000296543 ; ENSG00000164134 . [Q9BXJ9-1 ]
    GeneIDi 80155.
    KEGGi hsa:80155.
    UCSCi uc003ihu.1. human. [Q9BXJ9-1 ]

    Organism-specific databases

    CTDi 80155.
    GeneCardsi GC04P140222.
    HGNCi HGNC:30782. NAA15.
    HPAi HPA023589.
    HPA050661.
    MIMi 608000. gene.
    neXtProti NX_Q9BXJ9.
    PharmGKBi PA165664293.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0457.
    HOGENOMi HOG000191711.
    HOVERGENi HBG052576.
    InParanoidi Q9BXJ9.
    KOi K00670.
    OMAi YDSLPHR.
    OrthoDBi EOG747PKD.
    PhylomeDBi Q9BXJ9.
    TreeFami TF106301.

    Enzyme and pathway databases

    BRENDAi 2.3.1.88. 2681.

    Miscellaneous databases

    ChiTaRSi NAA15. human.
    GeneWikii NARG1.
    GenomeRNAii 80155.
    NextBioi 70453.
    PROi Q9BXJ9.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9BXJ9.
    Bgeei Q9BXJ9.
    CleanExi HS_NARG1.
    Genevestigatori Q9BXJ9.

    Family and domain databases

    Gene3Di 1.25.40.10. 3 hits.
    InterProi IPR021183. NatA_aux_su.
    IPR013026. TPR-contain_dom.
    IPR011990. TPR-like_helical.
    IPR013105. TPR_2.
    IPR019734. TPR_repeat.
    [Graphical view ]
    Pfami PF12569. NARP1. 1 hit.
    PF07719. TPR_2. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000422. N-terminal-AcTrfase-A_aux_su. 1 hit.
    SMARTi SM00028. TPR. 4 hits.
    [Graphical view ]
    PROSITEi PS50005. TPR. 5 hits.
    PS50293. TPR_REGION. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Serological identification and expression analysis of gastric cancer-associated genes."
      Line A., Stengrevics A., Slucka Z., Li G., Jankevics E., Rees R.C.
      Br. J. Cancer 86:1824-1830(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
      Tissue: Gastric adenocarcinoma.
    2. "Regulation of osteocalcin gene expression by a novel Ku antigen transcription factor complex."
      Willis D.M., Loewy A.P., Charlton-Kachigian N., Shao J.-S., Ornitz D.M., Towler D.A.
      J. Biol. Chem. 277:37280-37291(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), IDENTIFICATION BY MASS SPECTROMETRY, INTERACTION WITH XRCC6 AND XRCC5, FUNCTION.
      Tissue: Heart and Osteoblast.
    3. "NATH, a novel gene overexpressed in papillary thyroid carcinomas."
      Fluge O., Bruland O., Akslen L.A., Varhaug J.E., Lillehaug J.R.
      Oncogene 21:5056-5068(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
      Tissue: Thyroid carcinoma.
    4. "Cloning and analysis of a novel gene encoding N-terminal acetyltransferase subunit."
      He Y.G., Xie Y.F., Chen Y., Qian W., Lai J.H., Tan D.Y.
      Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao 34:353-357(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Ovary.
    6. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Brain and Lymph.
    9. "Suppressed expression of tubedown-1 in retinal neovascularization of proliferative diabetic retinopathy."
      Gendron R.L., Good W.V., Adams L.C., Paradis H.
      Invest. Ophthalmol. Vis. Sci. 42:3000-3007(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, TISSUE SPECIFICITY.
    10. "Identification and characterization of the human ARD1-NATH protein acetyltransferase complex."
      Arnesen T., Anderson D., Baldersheim C., Lanotte M., Varhaug J.E., Lillehaug J.R.
      Biochem. J. 386:433-443(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION, IDENTIFICATION BY MASS SPECTROMETRY, INTERACTION WITH NAA10.
    11. "Characterization of hARD2, a processed hARD1 gene duplicate, encoding a human protein N-alpha-acetyltransferase."
      Arnesen T., Betts M.J., Pendino F., Liberles D.A., Anderson D., Caro J., Kong X., Varhaug J.E., Lillehaug J.R.
      BMC Biochem. 7:13-13(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH NAA11.
    12. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
      Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
      Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    13. "Cloning and characterization of hNAT5/hSAN: an evolutionarily conserved component of the NatA protein N-alpha-acetyltransferase complex."
      Arnesen T., Anderson D., Torsvik J., Halseth H.B., Varhaug J.E., Lillehaug J.R.
      Gene 371:291-295(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH NAA50.
    14. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    15. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    16. "A synopsis of eukaryotic Nalpha-terminal acetyltransferases: nomenclature, subunits and substrates."
      Polevoda B., Arnesen T., Sherman F.
      BMC Proc. 3:S2-S2(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: NOMENCLATURE.
    17. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-399 AND SER-403, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    18. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
      Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
      Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-262; LYS-735 AND LYS-756, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    19. "The chaperone-like protein HYPK acts together with NatA in cotranslational N-terminal acetylation and prevention of Huntingtin aggregation."
      Arnesen T., Starheim K.K., Van Damme P., Evjenth R., Dinh H., Betts M.J., Ryningen A., Vandekerckhove J., Gevaert K., Anderson D.
      Mol. Cell. Biol. 30:1898-1909(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH HYPK, SUBUNIT.
    20. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-856, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    21. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    22. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-588 AND SER-856, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    23. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiNAA15_HUMAN
    AccessioniPrimary (citable) accession number: Q9BXJ9
    Secondary accession number(s): D3DNY6
    , Q52LG9, Q8IWH4, Q8NEV2, Q9H8P6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 4, 2005
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 126 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 4
      Human chromosome 4: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3