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Q9BXJ9

- NAA15_HUMAN

UniProt

Q9BXJ9 - NAA15_HUMAN

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Protein
N-alpha-acetyltransferase 15, NatA auxiliary subunit
Gene
NAA15, GA19, NARG1, NATH, TBDN100
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Auxillary subunit of the N-terminal acetyltransferase A (NatA) complex which displays alpha (N-terminal) acetyltransferase activity. The NAT activity may be important for vascular, hematopoietic and neuronal growth and development. Required to control retinal neovascularization in adult ocular endothelial cells. In complex with XRCC6 and XRCC5 (Ku80), up-regulates transcription from the osteocalcin promoter.3 Publications

GO - Molecular functioni

  1. N-acetyltransferase activity Source: Ensembl
  2. poly(A) RNA binding Source: UniProtKB
  3. protein binding Source: UniProtKB
  4. ribosome binding Source: UniProt
Complete GO annotation...

GO - Biological processi

  1. N-terminal protein amino acid acetylation Source: UniProtKB
  2. angiogenesis Source: UniProtKB-KW
  3. cell differentiation Source: UniProtKB-KW
  4. negative regulation of apoptotic process Source: UniProt
  5. positive regulation of transcription, DNA-templated Source: UniProtKB
  6. protein stabilization Source: UniProt
  7. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Angiogenesis, Differentiation, Transcription, Transcription regulation

Enzyme and pathway databases

BRENDAi2.3.1.88. 2681.

Names & Taxonomyi

Protein namesi
Recommended name:
N-alpha-acetyltransferase 15, NatA auxiliary subunit
Alternative name(s):
Gastric cancer antigen Ga19
N-terminal acetyltransferase
NMDA receptor-regulated protein 1
Protein tubedown-1
Tbdn100
Gene namesi
Name:NAA15
Synonyms:GA19, NARG1, NATH, TBDN100
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 4

Organism-specific databases

HGNCiHGNC:30782. NAA15.

Subcellular locationi

Cytoplasm. Nucleus
Note: Mainly cytoplasmic, nuclear in some cases. Present in the free cytosolic and cytoskeleton-bound polysomes, but not in the membrane-bound polysomes.2 Publications

GO - Cellular componenti

  1. NatA complex Source: UniProtKB
  2. cytoplasm Source: UniProtKB
  3. nucleus Source: UniProtKB
  4. transcription factor complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA165664293.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 866866N-alpha-acetyltransferase 15, NatA auxiliary subunit
PRO_0000106294Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei262 – 2621N6-acetyllysine1 Publication
Modified residuei399 – 3991Phosphothreonine1 Publication
Modified residuei403 – 4031Phosphoserine1 Publication
Modified residuei588 – 5881Phosphoserine1 Publication
Modified residuei735 – 7351N6-acetyllysine1 Publication
Modified residuei756 – 7561N6-acetyllysine1 Publication
Modified residuei855 – 8551Phosphoserine By similarity
Modified residuei856 – 8561Phosphoserine2 Publications

Post-translational modificationi

Cleaved by caspases during apoptosis, resulting in a stable 35 kDa fragment.

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ9BXJ9.
PaxDbiQ9BXJ9.
PRIDEiQ9BXJ9.

PTM databases

PhosphoSiteiQ9BXJ9.

Expressioni

Tissue specificityi

Expressed at high levels in testis and in ocular endothelial cells. Also found in brain (corpus callosum), heart, colon, bone marrow and at lower levels in most adult tissues, including thyroid, liver, pancreas, mammary and salivary glands, lung, ovary, urogenital system and upper gastrointestinal tract. Overexpressed in gastric cancer, in papillary thyroid carcinomas and in a Burkitt lymphoma cell line (Daudi). Specifically suppressed in abnormal proliferating blood vessels in eyes of patients with proliferative diabetic retinopathy.3 Publications

Gene expression databases

ArrayExpressiQ9BXJ9.
BgeeiQ9BXJ9.
CleanExiHS_NARG1.
GenevestigatoriQ9BXJ9.

Organism-specific databases

HPAiHPA023589.
HPA050661.

Interactioni

Subunit structurei

Component of the N-terminal acetyltransferase A (NatA) complex composed of NAA10 or probably NAA11 and NAA15. Interacts with XRCC6, NAA50 and XRCC5. Associates with HYPK when in a complex with NAA10.5 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
NAA50Q9GZZ12EBI-1042540,EBI-1052523

Protein-protein interaction databases

BioGridi123146. 20 interactions.
IntActiQ9BXJ9. 6 interactions.
STRINGi9606.ENSP00000296543.

Structurei

3D structure databases

ProteinModelPortaliQ9BXJ9.
SMRiQ9BXJ9. Positions 1-780.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati46 – 7934TPR 1
Add
BLAST
Repeati80 – 11334TPR 2
Add
BLAST
Repeati148 – 18437TPR 3
Add
BLAST
Repeati224 – 25734TPR 4
Add
BLAST
Repeati374 – 40734TPR 5
Add
BLAST
Repeati409 – 44133TPR 6
Add
BLAST
Repeati485 – 51834TPR 7
Add
BLAST
Repeati672 – 70534TPR 8
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni500 – 866367Interaction with HYPK
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi612 – 62918Bipartite nuclear localization signal Reviewed prediction
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi629 – 6324Poly-Asp

Sequence similaritiesi

Contains 8 TPR repeats.

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

eggNOGiCOG0457.
HOGENOMiHOG000191711.
HOVERGENiHBG052576.
InParanoidiQ9BXJ9.
KOiK00670.
OMAiYDSLPHR.
OrthoDBiEOG747PKD.
PhylomeDBiQ9BXJ9.
TreeFamiTF106301.

Family and domain databases

Gene3Di1.25.40.10. 3 hits.
InterProiIPR021183. NatA_aux_su.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical.
IPR013105. TPR_2.
IPR019734. TPR_repeat.
[Graphical view]
PfamiPF12569. NARP1. 1 hit.
PF07719. TPR_2. 1 hit.
[Graphical view]
PIRSFiPIRSF000422. N-terminal-AcTrfase-A_aux_su. 1 hit.
SMARTiSM00028. TPR. 4 hits.
[Graphical view]
PROSITEiPS50005. TPR. 5 hits.
PS50293. TPR_REGION. 2 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9BXJ9-1) [UniParc]FASTAAdd to Basket

Also known as: Long

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MPAVSLPPKE NALFKRILRC YEHKQYRNGL KFCKQILSNP KFAEHGETLA    50
MKGLTLNCLG KKEEAYELVR RGLRNDLKSH VCWHVYGLLQ RSDKKYDEAI 100
KCYRNALKWD KDNLQILRDL SLLQIQMRDL EGYRETRYQL LQLRPAQRAS 150
WIGYAIAYHL LEDYEMAAKI LEEFRKTQQT SPDKVDYEYS ELLLYQNQVL 200
REAGLYREAL EHLCTYEKQI CDKLAVEETK GELLLQLCRL EDAADVYRGL 250
QERNPENWAY YKGLEKALKP ANMLERLKIY EEAWTKYPRG LVPRRLPLNF 300
LSGEKFKECL DKFLRMNFSK GCPPVFNTLR SLYKDKEKVA IIEELVVGYE 350
TSLKSCRLFN PNDDGKEEPP TTLLWVQYYL AQHYDKIGQP SIALEYINTA 400
IESTPTLIEL FLVKAKIYKH AGNIKEAARW MDEAQALDTA DRFINSKCAK 450
YMLKANLIKE AEEMCSKFTR EGTSAVENLN EMQCMWFQTE CAQAYKAMNK 500
FGEALKKCHE IERHFIEITD DQFDFHTYCM RKITLRSYVD LLKLEDVLRQ 550
HPFYFKAARI AIEIYLKLHD NPLTDENKEH EADTANMSDK ELKKLRNKQR 600
RAQKKAQIEE EKKNAEKEKQ QRNQKKKKDD DDEEIGGPKE ELIPEKLAKV 650
ETPLEEAIKF LTPLKNLVKN KIETHLFAFE IYFRKEKFLL MLQSVKRAFA 700
IDSSHPWLHE CMIRLFNTAV CESKDLSDTV RTVLKQEMNR LFGATNPKNF 750
NETFLKRNSD SLPHRLSAAK MVYYLDPSSQ KRAIELATTL DESLTNRNLQ 800
TCMEVLEALY DGSLGDCKEA AEIYRANCHK LFPYALAFMP PGYEEDMKIT 850
VNGDSSAEAE ELANEI 866
Length:866
Mass (Da):101,272
Last modified:June 1, 2001 - v1
Checksum:i6B4BA23B99D99121
GO
Isoform 2 (identifier: Q9BXJ9-4) [UniParc]FASTAAdd to Basket

Also known as: Short

The sequence of this isoform differs from the canonical sequence as follows:
     514-525: HFIEITDDQFDF → KSLMTSLTFIHTV
     526-866: Missing.

Show »
Length:526
Mass (Da):61,602
Checksum:i6C66BCE4B7377BB6
GO

Sequence cautioni

The sequence AAH39818.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei514 – 52512HFIEI…DQFDF → KSLMTSLTFIHTV in isoform 2.
VSP_012560Add
BLAST
Alternative sequencei526 – 866341Missing in isoform 2.
VSP_012561Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti425 – 4251K → R in AAM48746. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY039242 mRNA. Translation: AAK68661.1.
AY112670 mRNA. Translation: AAM48746.1.
AJ314788 mRNA. Translation: CAC43228.1.
AF327722 mRNA. Translation: AAK15707.1.
AK023402 mRNA. Translation: BAB14562.1.
AC097376 Genomic DNA. Translation: AAY40950.1.
CH471056 Genomic DNA. Translation: EAX05119.1.
BC039818 mRNA. Translation: AAH39818.1. Sequence problems.
BC093928 mRNA. Translation: AAH93928.1.
BC104806 mRNA. Translation: AAI04807.1.
CCDSiCCDS43270.1. [Q9BXJ9-1]
RefSeqiNP_476516.1. NM_057175.3. [Q9BXJ9-1]
UniGeneiHs.745047.

Genome annotation databases

EnsembliENST00000296543; ENSP00000296543; ENSG00000164134. [Q9BXJ9-1]
GeneIDi80155.
KEGGihsa:80155.
UCSCiuc003ihu.1. human. [Q9BXJ9-1]

Polymorphism databases

DMDMi57012969.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY039242 mRNA. Translation: AAK68661.1 .
AY112670 mRNA. Translation: AAM48746.1 .
AJ314788 mRNA. Translation: CAC43228.1 .
AF327722 mRNA. Translation: AAK15707.1 .
AK023402 mRNA. Translation: BAB14562.1 .
AC097376 Genomic DNA. Translation: AAY40950.1 .
CH471056 Genomic DNA. Translation: EAX05119.1 .
BC039818 mRNA. Translation: AAH39818.1 . Sequence problems.
BC093928 mRNA. Translation: AAH93928.1 .
BC104806 mRNA. Translation: AAI04807.1 .
CCDSi CCDS43270.1. [Q9BXJ9-1 ]
RefSeqi NP_476516.1. NM_057175.3. [Q9BXJ9-1 ]
UniGenei Hs.745047.

3D structure databases

ProteinModelPortali Q9BXJ9.
SMRi Q9BXJ9. Positions 1-780.
ModBasei Search...

Protein-protein interaction databases

BioGridi 123146. 20 interactions.
IntActi Q9BXJ9. 6 interactions.
STRINGi 9606.ENSP00000296543.

PTM databases

PhosphoSitei Q9BXJ9.

Polymorphism databases

DMDMi 57012969.

Proteomic databases

MaxQBi Q9BXJ9.
PaxDbi Q9BXJ9.
PRIDEi Q9BXJ9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000296543 ; ENSP00000296543 ; ENSG00000164134 . [Q9BXJ9-1 ]
GeneIDi 80155.
KEGGi hsa:80155.
UCSCi uc003ihu.1. human. [Q9BXJ9-1 ]

Organism-specific databases

CTDi 80155.
GeneCardsi GC04P140222.
HGNCi HGNC:30782. NAA15.
HPAi HPA023589.
HPA050661.
MIMi 608000. gene.
neXtProti NX_Q9BXJ9.
PharmGKBi PA165664293.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0457.
HOGENOMi HOG000191711.
HOVERGENi HBG052576.
InParanoidi Q9BXJ9.
KOi K00670.
OMAi YDSLPHR.
OrthoDBi EOG747PKD.
PhylomeDBi Q9BXJ9.
TreeFami TF106301.

Enzyme and pathway databases

BRENDAi 2.3.1.88. 2681.

Miscellaneous databases

ChiTaRSi NAA15. human.
GeneWikii NARG1.
GenomeRNAii 80155.
NextBioi 70453.
PROi Q9BXJ9.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9BXJ9.
Bgeei Q9BXJ9.
CleanExi HS_NARG1.
Genevestigatori Q9BXJ9.

Family and domain databases

Gene3Di 1.25.40.10. 3 hits.
InterProi IPR021183. NatA_aux_su.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical.
IPR013105. TPR_2.
IPR019734. TPR_repeat.
[Graphical view ]
Pfami PF12569. NARP1. 1 hit.
PF07719. TPR_2. 1 hit.
[Graphical view ]
PIRSFi PIRSF000422. N-terminal-AcTrfase-A_aux_su. 1 hit.
SMARTi SM00028. TPR. 4 hits.
[Graphical view ]
PROSITEi PS50005. TPR. 5 hits.
PS50293. TPR_REGION. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Serological identification and expression analysis of gastric cancer-associated genes."
    Line A., Stengrevics A., Slucka Z., Li G., Jankevics E., Rees R.C.
    Br. J. Cancer 86:1824-1830(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
    Tissue: Gastric adenocarcinoma.
  2. "Regulation of osteocalcin gene expression by a novel Ku antigen transcription factor complex."
    Willis D.M., Loewy A.P., Charlton-Kachigian N., Shao J.-S., Ornitz D.M., Towler D.A.
    J. Biol. Chem. 277:37280-37291(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), IDENTIFICATION BY MASS SPECTROMETRY, INTERACTION WITH XRCC6 AND XRCC5, FUNCTION.
    Tissue: Heart and Osteoblast.
  3. "NATH, a novel gene overexpressed in papillary thyroid carcinomas."
    Fluge O., Bruland O., Akslen L.A., Varhaug J.E., Lillehaug J.R.
    Oncogene 21:5056-5068(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    Tissue: Thyroid carcinoma.
  4. "Cloning and analysis of a novel gene encoding N-terminal acetyltransferase subunit."
    He Y.G., Xie Y.F., Chen Y., Qian W., Lai J.H., Tan D.Y.
    Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao 34:353-357(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Ovary.
  6. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain and Lymph.
  9. "Suppressed expression of tubedown-1 in retinal neovascularization of proliferative diabetic retinopathy."
    Gendron R.L., Good W.V., Adams L.C., Paradis H.
    Invest. Ophthalmol. Vis. Sci. 42:3000-3007(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY.
  10. "Identification and characterization of the human ARD1-NATH protein acetyltransferase complex."
    Arnesen T., Anderson D., Baldersheim C., Lanotte M., Varhaug J.E., Lillehaug J.R.
    Biochem. J. 386:433-443(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, IDENTIFICATION BY MASS SPECTROMETRY, INTERACTION WITH NAA10.
  11. "Characterization of hARD2, a processed hARD1 gene duplicate, encoding a human protein N-alpha-acetyltransferase."
    Arnesen T., Betts M.J., Pendino F., Liberles D.A., Anderson D., Caro J., Kong X., Varhaug J.E., Lillehaug J.R.
    BMC Biochem. 7:13-13(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH NAA11.
  12. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
    Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
    Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  13. "Cloning and characterization of hNAT5/hSAN: an evolutionarily conserved component of the NatA protein N-alpha-acetyltransferase complex."
    Arnesen T., Anderson D., Torsvik J., Halseth H.B., Varhaug J.E., Lillehaug J.R.
    Gene 371:291-295(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH NAA50.
  14. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  15. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  16. "A synopsis of eukaryotic Nalpha-terminal acetyltransferases: nomenclature, subunits and substrates."
    Polevoda B., Arnesen T., Sherman F.
    BMC Proc. 3:S2-S2(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NOMENCLATURE.
  17. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-399 AND SER-403, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  18. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
    Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
    Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-262; LYS-735 AND LYS-756, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  19. "The chaperone-like protein HYPK acts together with NatA in cotranslational N-terminal acetylation and prevention of Huntingtin aggregation."
    Arnesen T., Starheim K.K., Van Damme P., Evjenth R., Dinh H., Betts M.J., Ryningen A., Vandekerckhove J., Gevaert K., Anderson D.
    Mol. Cell. Biol. 30:1898-1909(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH HYPK, SUBUNIT.
  20. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-856, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  21. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  22. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-588 AND SER-856, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  23. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiNAA15_HUMAN
AccessioniPrimary (citable) accession number: Q9BXJ9
Secondary accession number(s): D3DNY6
, Q52LG9, Q8IWH4, Q8NEV2, Q9H8P6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: June 1, 2001
Last modified: July 9, 2014
This is version 125 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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