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Protein

Transmembrane protein 120A

Gene

TMEM120A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Necessary for efficient adipogenesis (PubMed:26024229).1 Publication

GO - Biological processi

  • fat cell differentiation Source: UniProtKB
  • protein heterooligomerization Source: UniProtKB
  • protein homooligomerization Source: UniProtKB
Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:G66-33612-MONOMER.

Protein family/group databases

TCDBi9.B.112.1.2. the stress-inducible transmembrane protein (tmpit1) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 120A
Alternative name(s):
Transmembrane protein induced by tumor necrosis factor alpha
Gene namesi
Name:TMEM120A
Synonyms:TMPIT
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:21697. TMEM120A.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 135ExtracellularSequence analysisAdd BLAST135
Transmembranei136 – 156HelicalSequence analysisAdd BLAST21
Topological domaini157 – 162CytoplasmicSequence analysis6
Transmembranei163 – 183HelicalSequence analysisAdd BLAST21
Topological domaini184 – 190ExtracellularSequence analysis7
Transmembranei191 – 211HelicalSequence analysisAdd BLAST21
Topological domaini212 – 273CytoplasmicSequence analysisAdd BLAST62
Transmembranei274 – 294HelicalSequence analysisAdd BLAST21
Topological domaini295 – 305ExtracellularSequence analysisAdd BLAST11
Transmembranei306 – 326HelicalSequence analysisAdd BLAST21
Topological domaini327 – 343CytoplasmicSequence analysisAdd BLAST17

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000189077.
PharmGKBiPA162405861.

Polymorphism and mutation databases

BioMutaiTMEM120A.
DMDMi74717620.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003093391 – 343Transmembrane protein 120AAdd BLAST343

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi117N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ9BXJ8.
MaxQBiQ9BXJ8.
PeptideAtlasiQ9BXJ8.
PRIDEiQ9BXJ8.

PTM databases

iPTMnetiQ9BXJ8.
PhosphoSitePlusiQ9BXJ8.
SwissPalmiQ9BXJ8.

Expressioni

Gene expression databases

CleanExiHS_TMEM120A.
ExpressionAtlasiQ9BXJ8. baseline and differential.
GenevisibleiQ9BXJ8. HS.

Interactioni

Subunit structurei

Homooligomer and heterooligomer with TMEM120B.1 Publication

Protein-protein interaction databases

BioGridi123777. 14 interactors.
IntActiQ9BXJ8. 9 interactors.
MINTiMINT-1416635.

Structurei

3D structure databases

ProteinModelPortaliQ9BXJ8.
SMRiQ9BXJ8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TMEM120 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00390000007848.
HOVERGENiHBG108532.
InParanoidiQ9BXJ8.
PhylomeDBiQ9BXJ8.

Family and domain databases

InterProiIPR012926. TMPIT.
[Graphical view]
PANTHERiPTHR21433. PTHR21433. 1 hit.
PfamiPF07851. TMPIT. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9BXJ8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MQPPPPGPLG DCLRDWEDLQ QDFQNIQETH RLYRLKLEEL TKLQNNCTSS
60 70 80 90 100
ITRQKKRLQE LALALKKCKP SLPAEAEGAA QELENQMKER QGLFFDMEAY
110 120 130 140 150
LPKKNGLYLS LVLGNVNVTL LSKQAKFAYK DEYEKFKLYL TIILILISFT
160 170 180 190 200
CRFLLNSRVT DAAFNFLLVW YYCTLTIRES ILINNGSRIK GWWVFHHYVS
210 220 230 240 250
TFLSGVMLTW PDGLMYQKFR NQFLSFSMYQ SFVQFLQYYY QSGCLYRLRA
260 270 280 290 300
LGERHTMDLT VEGFQSWMWR GLTFLLPFLF FGHFWQLFNA LTLFNLAQDP
310 320 330 340
QCKEWQVLMC GFPFLLLFLG NFFTTLRVVH HKFHSQRHGS KKD
Length:343
Mass (Da):40,610
Last modified:June 1, 2001 - v1
Checksum:i7A6E241804F59A96
GO
Isoform 2 (identifier: Q9BXJ8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     189-343: IKGWWVFHHY...HSQRHGSKKD → WAGRALREGS...SFLWTLLAAF

Show »
Length:322
Mass (Da):35,916
Checksum:iE7719223ECE863B0
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03693386Q → R.1 PublicationCorresponds to variant rs17852664dbSNPEnsembl.1
Natural variantiVAR_036934201T → A.1 PublicationCorresponds to variant rs17855697dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_029148189 – 343IKGWW…GSKKD → WAGRALREGSMEWGARTLRE AGTGAGGDGGSLLQDQRLVG VPSLRVHLPVGSHADVVRRS HVPEIPEPIPLLFHVPELRA VSPVLLPERLPLPPAGAGRA AHHGPHCGGLPVLDVAGPHL PAAFSFLWTLLAAF in isoform 2. 1 PublicationAdd BLAST155

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF327923 mRNA. Translation: AAK16442.1.
CH471066 Genomic DNA. Translation: EAW71783.1.
BC029487 mRNA. Translation: AAH29487.1.
BC051850 mRNA. Translation: AAH51850.1.
CCDSiCCDS64688.1. [Q9BXJ8-1]
RefSeqiNP_114131.1. NM_031925.2. [Q9BXJ8-1]
UniGeneiHs.488835.

Genome annotation databases

EnsembliENST00000493111; ENSP00000473983; ENSG00000189077. [Q9BXJ8-1]
GeneIDi83862.
KEGGihsa:83862.
UCSCiuc032ztu.2. human. [Q9BXJ8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF327923 mRNA. Translation: AAK16442.1.
CH471066 Genomic DNA. Translation: EAW71783.1.
BC029487 mRNA. Translation: AAH29487.1.
BC051850 mRNA. Translation: AAH51850.1.
CCDSiCCDS64688.1. [Q9BXJ8-1]
RefSeqiNP_114131.1. NM_031925.2. [Q9BXJ8-1]
UniGeneiHs.488835.

3D structure databases

ProteinModelPortaliQ9BXJ8.
SMRiQ9BXJ8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123777. 14 interactors.
IntActiQ9BXJ8. 9 interactors.
MINTiMINT-1416635.

Protein family/group databases

TCDBi9.B.112.1.2. the stress-inducible transmembrane protein (tmpit1) family.

PTM databases

iPTMnetiQ9BXJ8.
PhosphoSitePlusiQ9BXJ8.
SwissPalmiQ9BXJ8.

Polymorphism and mutation databases

BioMutaiTMEM120A.
DMDMi74717620.

Proteomic databases

EPDiQ9BXJ8.
MaxQBiQ9BXJ8.
PeptideAtlasiQ9BXJ8.
PRIDEiQ9BXJ8.

Protocols and materials databases

DNASUi83862.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000493111; ENSP00000473983; ENSG00000189077. [Q9BXJ8-1]
GeneIDi83862.
KEGGihsa:83862.
UCSCiuc032ztu.2. human. [Q9BXJ8-1]

Organism-specific databases

CTDi83862.
GeneCardsiTMEM120A.
HGNCiHGNC:21697. TMEM120A.
MIMi616550. gene.
neXtProtiNX_Q9BXJ8.
OpenTargetsiENSG00000189077.
PharmGKBiPA162405861.
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00390000007848.
HOVERGENiHBG108532.
InParanoidiQ9BXJ8.
PhylomeDBiQ9BXJ8.

Enzyme and pathway databases

BioCyciZFISH:G66-33612-MONOMER.

Miscellaneous databases

ChiTaRSiTMEM120A. human.
GenomeRNAii83862.
PROiQ9BXJ8.
SOURCEiSearch...

Gene expression databases

CleanExiHS_TMEM120A.
ExpressionAtlasiQ9BXJ8. baseline and differential.
GenevisibleiQ9BXJ8. HS.

Family and domain databases

InterProiIPR012926. TMPIT.
[Graphical view]
PANTHERiPTHR21433. PTHR21433. 1 hit.
PfamiPF07851. TMPIT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiT120A_HUMAN
AccessioniPrimary (citable) accession number: Q9BXJ8
Secondary accession number(s): Q86TE9, Q8N6P1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: June 1, 2001
Last modified: November 30, 2016
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.