ID   C1QT2_HUMAN             Reviewed;         285 AA.
AC   Q9BXJ5;
DT   16-APR-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   16-JUN-2009, entry version 69.
DE   RecName: Full=Complement C1q tumor necrosis factor-related protein 2;
DE   Flags: Precursor;
GN   Name=C1QTNF2; Synonyms=CTRP2; ORFNames=UNQ6349/PRO21054;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Piddington C.S., Bishop P.;
RT   "Homo sapiens complement-c1q tumor necrosis factor-related protein.";
RL   Submitted (DEC-2000) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   MEDLINE=22887296; PubMed=12975309; DOI=10.1101/gr.1293003;
RA   Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA   Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA   Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S.,
RA   Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J.,
RA   Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J.,
RA   Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A.,
RA   Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H.,
RA   Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D.,
RA   Wood W.I., Godowski P.J., Gray A.M.;
RT   "The secreted protein discovery initiative (SPDI), a large-scale
RT   effort to identify novel human secreted and transmembrane proteins: a
RT   bioinformatics assessment.";
RL   Genome Res. 13:2265-2270(2003).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15372022; DOI=10.1038/nature02919;
RA   Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S.,
RA   Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M.,
RA   She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.,
RA   Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M.,
RA   Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T.,
RA   Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M.,
RA   Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K.,
RA   Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C.,
RA   Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M.,
RA   Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A.,
RA   Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M.,
RA   Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M.,
RA   Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S.,
RA   Richardson P., Lucas S.M., Myers R.M., Rubin E.M.;
RT   "The DNA sequence and comparative analysis of human chromosome 5.";
RL   Nature 431:268-274(2004).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain, and Muscle;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- SUBCELLULAR LOCATION: Secreted (Potential).
CC   -!- SIMILARITY: Contains 1 C1q domain.
CC   -!- SIMILARITY: Contains 1 collagen-like domain.
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DR   EMBL; AF329836; AAK17960.1; -; mRNA.
DR   EMBL; AY358839; AAQ89198.1; -; mRNA.
DR   EMBL; AC091842; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC112191; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC011699; AAH11699.1; -; mRNA.
DR   EMBL; BC054506; AAH54506.1; -; mRNA.
DR   IPI; IPI00873947; -.
DR   RefSeq; NP_114114.2; -.
DR   UniGene; Hs.110062; -.
DR   HSSP; Q60994; 1C28.
DR   PRIDE; Q9BXJ5; -.
DR   Ensembl; ENSG00000145861; Homo sapiens.
DR   GeneID; 114898; -.
DR   KEGG; hsa:114898; -.
DR   GeneCards; GC05M159707; -.
DR   H-InvDB; HIX0005376; -.
DR   HGNC; HGNC:14325; C1QTNF2.
DR   PharmGKB; PA25629; -.
DR   HOGENOM; Q9BXJ5; -.
DR   HOVERGEN; Q9BXJ5; -.
DR   NextBio; 79402; -.
DR   ArrayExpress; Q9BXJ5; -.
DR   Bgee; Q9BXJ5; -.
DR   CleanEx; HS_C1QTNF2; -.
DR   GermOnline; ENSG00000145861; Homo sapiens.
DR   InterPro; IPR001073; C1q.
DR   InterPro; IPR008160; Collagen.
DR   InterPro; IPR008983; Tumour_necrosis_fac-like.
DR   Gene3D; G3DSA:2.60.120.40; Tumour_necrosis_fac-like; 1.
DR   Pfam; PF00386; C1q; 1.
DR   Pfam; PF01391; Collagen; 2.
DR   PRINTS; PR00007; COMPLEMNTC1Q.
DR   SMART; SM00110; C1Q; 1.
DR   PROSITE; PS50871; C1Q; 1.
PE   2: Evidence at transcript level;
KW   Collagen; Secreted; Signal.
FT   SIGNAL        1     15       Potential.
FT   CHAIN        16    285       Complement C1q tumor necrosis factor-
FT                                related protein 2.
FT                                /FTId=PRO_0000003530.
FT   DOMAIN       40    141       Collagen-like.
FT   DOMAIN      145    285       C1q.
SQ   SEQUENCE   285 AA;  29952 MW;  7E31FF9868D4EDFA CRC64;
     MIPWVLLACA LPCAADPLLG AFARRDFRKG SPQLVCSLPG PQGPPGPPGA PGPSGMMGRM
     GFPGKDGQDG HDGDRGDSGE EGPPGRTGNR GKPGPKGKAG AIGRAGPRGP KGVNGTPGKH
     GTPGKKGPKG KKGEPGLPGP CSCGSGHTKS AFSVAVTKSY PRERLPIKFD KILMNEGGHY
     NASSGKFVCG VPGIYYFTYD ITLANKHLAI GLVHNGQYRI RTFDANTGNH DVASGSTILA
     LKQGDEVWLQ IFYSEQNGLF YDPYWTDSLF TGFLIYADQD DPNEV
//