Q9BXJ5 (C1QT2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Complement C1q tumor necrosis factor-related protein 2

Gene names

Name:	C1QTNF2
Synonyms:	CTRP2
ORF Names:	UNQ6349/PRO21054

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	285 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subunit structure	May interact with FAM132B By similarity.
Subcellular location	Secreted Potential.
Sequence similarities	Contains 1 C1q domain. Contains 1 collagen-like domain.
Sequence caution	The sequence AAH11699.2 differs from that shown. Reason: Erroneous initiation. The sequence AAH54506.2 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Cellular component	Secreted
Domain	Collagen Signal
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	activation of MAPK activity Inferred from electronic annotation. Source: Compara positive regulation of fatty acid oxidation Inferred from electronic annotation. Source: Compara positive regulation of glucose import Inferred from electronic annotation. Source: Compara positive regulation of glycogen biosynthetic process Inferred from electronic annotation. Source: Compara protein heterotrimerization Inferred from electronic annotation. Source: Compara protein homooligomerization Inferred from electronic annotation. Source: Compara
Cellular_component	collagen Inferred from electronic annotation. Source: UniProtKB-KW extracellular space Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 15	15	Potential
	Chain	16 – 285	270	Complement C1q tumor necrosis factor-related protein 2		PRO_0000003530
Regions
	Domain	40 – 141	102	Collagen-like
	Domain	145 – 281	137	C1q

Sequences

	Sequence		Length	Mass (Da)
	Q9BXJ5 [UniParc]. Last modified June 1, 2001. Version 1. Checksum: 7E31FF9868D4EDFA	FASTA	285	29,952
	10 20 30 40 50 60 MIPWVLLACA LPCAADPLLG AFARRDFRKG SPQLVCSLPG PQGPPGPPGA PGPSGMMGRM 70 80 90 100 110 120 GFPGKDGQDG HDGDRGDSGE EGPPGRTGNR GKPGPKGKAG AIGRAGPRGP KGVNGTPGKH 130 140 150 160 170 180 GTPGKKGPKG KKGEPGLPGP CSCGSGHTKS AFSVAVTKSY PRERLPIKFD KILMNEGGHY 190 200 210 220 230 240 NASSGKFVCG VPGIYYFTYD ITLANKHLAI GLVHNGQYRI RTFDANTGNH DVASGSTILA 250 260 270 280 LKQGDEVWLQ IFYSEQNGLF YDPYWTDSLF TGFLIYADQD DPNEV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Homo sapiens complement-c1q tumor necrosis factor-related protein." Piddington C.S., Bishop P. Submitted (DEC-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M. Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]	"The DNA sequence and comparative analysis of human chromosome 5." Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S. , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M. Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain and Muscle.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF329836 mRNA. Translation: AAK17960.1. AY358839 mRNA. Translation: AAQ89198.1. AC091842 Genomic DNA. No translation available. AC112191 Genomic DNA. No translation available. BC011699 mRNA. Translation: AAH11699.2. Different initiation. BC054506 mRNA. Translation: AAH54506.2. Different initiation.
IPI	IPI00011093.
RefSeq	NP_114114.2. NM_031908.4.
UniGene	Hs.110062.
3D structure databases
ProteinModelPortal	Q9BXJ5.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9BXJ5. 1 interaction.
PTM databases
PhosphoSite	Q9BXJ5.
Polymorphism databases
DMDM	20177866.
Proteomic databases
PaxDb	Q9BXJ5.
PRIDE	Q9BXJ5.
Protocols and materials databases
DNASU	114898.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000393975; ENSP00000377545; ENSG00000145861.
GeneID	114898.
KEGG	hsa:114898.
UCSC	uc003lyd.3. human.
Organism-specific databases
CTD	114898.
GeneCards	GC05M159707.
H-InvDB	HIX0005376.
HGNC	HGNC:14325. C1QTNF2.
neXtProt	NX_Q9BXJ5.
PharmGKB	PA25629.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG121676.
HOGENOM	HOG000085653.
HOVERGEN	HBG108220.
InParanoid	Q9BXJ5.
OrthoDB	EOG45MN6D.
PhylomeDB	Q9BXJ5.
Gene expression databases
Bgee	Q9BXJ5.
CleanEx	HS_C1QTNF2.
Genevestigator	Q9BXJ5.
GermOnline	ENSG00000145861. Homo sapiens.
Family and domain databases
Gene3D	2.60.120.40. 1 hit.
InterPro	IPR001073. C1q. IPR008160. Collagen. IPR008983. Tumour_necrosis_fac-like_dom. [Graphical view]
Pfam	PF00386. C1q. 1 hit. PF01391. Collagen. 2 hits. [Graphical view]
PRINTS	PR00007. COMPLEMNTC1Q.
SMART	SM00110. C1Q. 1 hit. [Graphical view]
SUPFAM	SSF49842. TNF_like. 1 hit.
PROSITE	PS50871. C1Q. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	114898.
NextBio	79402.

Entry information

Entry name

C1QT2_HUMAN

Accession

Primary (citable) accession number: Q9BXJ5

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 16, 2002
Last sequence update:	June 1, 2001
Last modified:	May 1, 2013
This is version 100 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.