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Q9BXJ5

- C1QT2_HUMAN

UniProt

Q9BXJ5 - C1QT2_HUMAN

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Protein

Complement C1q tumor necrosis factor-related protein 2

Gene
C1QTNF2, CTRP2, UNQ6349/PRO21054
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

GO - Biological processi

  1. activation of MAPK activity Source: Ensembl
  2. positive regulation of fatty acid oxidation Source: Ensembl
  3. positive regulation of glucose import Source: Ensembl
  4. positive regulation of glycogen biosynthetic process Source: Ensembl
  5. protein heterotrimerization Source: Ensembl
  6. protein homooligomerization Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Complement C1q tumor necrosis factor-related protein 2
Gene namesi
Name:C1QTNF2
Synonyms:CTRP2
ORF Names:UNQ6349/PRO21054
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 5

Organism-specific databases

HGNCiHGNC:14325. C1QTNF2.

Subcellular locationi

Secreted Reviewed prediction

GO - Cellular componenti

  1. collagen trimer Source: UniProtKB-KW
  2. extracellular space Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA25629.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1515 Reviewed predictionAdd
BLAST
Chaini16 – 285270Complement C1q tumor necrosis factor-related protein 2PRO_0000003530Add
BLAST

Proteomic databases

PaxDbiQ9BXJ5.
PRIDEiQ9BXJ5.

PTM databases

PhosphoSiteiQ9BXJ5.

Expressioni

Gene expression databases

BgeeiQ9BXJ5.
CleanExiHS_C1QTNF2.
GenevestigatoriQ9BXJ5.

Organism-specific databases

HPAiHPA061290.

Interactioni

Subunit structurei

May interact with FAM132B By similarity.

Protein-protein interaction databases

IntActiQ9BXJ5. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ9BXJ5.
SMRiQ9BXJ5. Positions 150-275.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini40 – 141102Collagen-likeAdd
BLAST
Domaini145 – 281137C1qAdd
BLAST

Sequence similaritiesi

Contains 1 C1q domain.

Keywords - Domaini

Collagen, Signal

Phylogenomic databases

eggNOGiNOG121676.
HOGENOMiHOG000085653.
HOVERGENiHBG108220.
InParanoidiQ9BXJ5.
OrthoDBiEOG70ZZPW.
PhylomeDBiQ9BXJ5.
TreeFamiTF329591.

Family and domain databases

Gene3Di2.60.120.40. 1 hit.
InterProiIPR001073. C1q.
IPR008160. Collagen.
IPR008983. Tumour_necrosis_fac-like_dom.
[Graphical view]
PfamiPF00386. C1q. 1 hit.
PF01391. Collagen. 2 hits.
[Graphical view]
PRINTSiPR00007. COMPLEMNTC1Q.
SMARTiSM00110. C1Q. 1 hit.
[Graphical view]
SUPFAMiSSF49842. SSF49842. 1 hit.
PROSITEiPS50871. C1Q. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9BXJ5-1 [UniParc]FASTAAdd to Basket

« Hide

MIPWVLLACA LPCAADPLLG AFARRDFRKG SPQLVCSLPG PQGPPGPPGA    50
PGPSGMMGRM GFPGKDGQDG HDGDRGDSGE EGPPGRTGNR GKPGPKGKAG 100
AIGRAGPRGP KGVNGTPGKH GTPGKKGPKG KKGEPGLPGP CSCGSGHTKS 150
AFSVAVTKSY PRERLPIKFD KILMNEGGHY NASSGKFVCG VPGIYYFTYD 200
ITLANKHLAI GLVHNGQYRI RTFDANTGNH DVASGSTILA LKQGDEVWLQ 250
IFYSEQNGLF YDPYWTDSLF TGFLIYADQD DPNEV 285
Length:285
Mass (Da):29,952
Last modified:June 1, 2001 - v1
Checksum:i7E31FF9868D4EDFA
GO

Sequence cautioni

The sequence AAH11699.2 differs from that shown. Reason: Erroneous initiation.
The sequence AAH54506.2 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF329836 mRNA. Translation: AAK17960.1.
AY358839 mRNA. Translation: AAQ89198.1.
AC091842 Genomic DNA. No translation available.
AC112191 Genomic DNA. No translation available.
BC011699 mRNA. Translation: AAH11699.2. Different initiation.
BC054506 mRNA. Translation: AAH54506.2. Different initiation.
RefSeqiNP_114114.2. NM_031908.4.
UniGeneiHs.110062.

Genome annotation databases

EnsembliENST00000393975; ENSP00000377545; ENSG00000145861.
GeneIDi114898.
KEGGihsa:114898.
UCSCiuc003lyd.3. human.

Polymorphism databases

DMDMi20177866.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF329836 mRNA. Translation: AAK17960.1 .
AY358839 mRNA. Translation: AAQ89198.1 .
AC091842 Genomic DNA. No translation available.
AC112191 Genomic DNA. No translation available.
BC011699 mRNA. Translation: AAH11699.2 . Different initiation.
BC054506 mRNA. Translation: AAH54506.2 . Different initiation.
RefSeqi NP_114114.2. NM_031908.4.
UniGenei Hs.110062.

3D structure databases

ProteinModelPortali Q9BXJ5.
SMRi Q9BXJ5. Positions 150-275.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q9BXJ5. 1 interaction.

PTM databases

PhosphoSitei Q9BXJ5.

Polymorphism databases

DMDMi 20177866.

Proteomic databases

PaxDbi Q9BXJ5.
PRIDEi Q9BXJ5.

Protocols and materials databases

DNASUi 114898.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000393975 ; ENSP00000377545 ; ENSG00000145861 .
GeneIDi 114898.
KEGGi hsa:114898.
UCSCi uc003lyd.3. human.

Organism-specific databases

CTDi 114898.
GeneCardsi GC05M159707.
H-InvDB HIX0005376.
HGNCi HGNC:14325. C1QTNF2.
HPAi HPA061290.
neXtProti NX_Q9BXJ5.
PharmGKBi PA25629.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG121676.
HOGENOMi HOG000085653.
HOVERGENi HBG108220.
InParanoidi Q9BXJ5.
OrthoDBi EOG70ZZPW.
PhylomeDBi Q9BXJ5.
TreeFami TF329591.

Miscellaneous databases

GenomeRNAii 114898.
NextBioi 79402.
PROi Q9BXJ5.

Gene expression databases

Bgeei Q9BXJ5.
CleanExi HS_C1QTNF2.
Genevestigatori Q9BXJ5.

Family and domain databases

Gene3Di 2.60.120.40. 1 hit.
InterProi IPR001073. C1q.
IPR008160. Collagen.
IPR008983. Tumour_necrosis_fac-like_dom.
[Graphical view ]
Pfami PF00386. C1q. 1 hit.
PF01391. Collagen. 2 hits.
[Graphical view ]
PRINTSi PR00007. COMPLEMNTC1Q.
SMARTi SM00110. C1Q. 1 hit.
[Graphical view ]
SUPFAMi SSF49842. SSF49842. 1 hit.
PROSITEi PS50871. C1Q. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Homo sapiens complement-c1q tumor necrosis factor-related protein."
    Piddington C.S., Bishop P.
    Submitted (DEC-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "The DNA sequence and comparative analysis of human chromosome 5."
    Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.
    , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
    Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain and Muscle.

Entry informationi

Entry nameiC1QT2_HUMAN
AccessioniPrimary (citable) accession number: Q9BXJ5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 16, 2002
Last sequence update: June 1, 2001
Last modified: July 9, 2014
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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