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Q9BXJ5

- C1QT2_HUMAN

UniProt

Q9BXJ5 - C1QT2_HUMAN

Protein

Complement C1q tumor necrosis factor-related protein 2

Gene

C1QTNF2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 110 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
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    Functioni

    GO - Biological processi

    1. activation of MAPK activity Source: Ensembl
    2. positive regulation of fatty acid oxidation Source: Ensembl
    3. positive regulation of glucose import Source: Ensembl
    4. positive regulation of glycogen biosynthetic process Source: Ensembl
    5. protein heterotrimerization Source: Ensembl
    6. protein homooligomerization Source: Ensembl

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Complement C1q tumor necrosis factor-related protein 2
    Gene namesi
    Name:C1QTNF2
    Synonyms:CTRP2
    ORF Names:UNQ6349/PRO21054
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 5

    Organism-specific databases

    HGNCiHGNC:14325. C1QTNF2.

    Subcellular locationi

    Secreted Curated

    GO - Cellular componenti

    1. collagen trimer Source: UniProtKB-KW
    2. extracellular space Source: Ensembl

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA25629.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1515Sequence AnalysisAdd
    BLAST
    Chaini16 – 285270Complement C1q tumor necrosis factor-related protein 2PRO_0000003530Add
    BLAST

    Proteomic databases

    PaxDbiQ9BXJ5.
    PRIDEiQ9BXJ5.

    PTM databases

    PhosphoSiteiQ9BXJ5.

    Expressioni

    Gene expression databases

    BgeeiQ9BXJ5.
    CleanExiHS_C1QTNF2.
    GenevestigatoriQ9BXJ5.

    Organism-specific databases

    HPAiHPA061290.

    Interactioni

    Subunit structurei

    May interact with FAM132B.By similarity

    Protein-protein interaction databases

    IntActiQ9BXJ5. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9BXJ5.
    SMRiQ9BXJ5. Positions 150-275.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini40 – 141102Collagen-likeAdd
    BLAST
    Domaini145 – 281137C1qPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 C1q domain.PROSITE-ProRule annotation
    Contains 1 collagen-like domain.Curated

    Keywords - Domaini

    Collagen, Signal

    Phylogenomic databases

    eggNOGiNOG121676.
    HOGENOMiHOG000085653.
    HOVERGENiHBG108220.
    InParanoidiQ9BXJ5.
    OrthoDBiEOG70ZZPW.
    PhylomeDBiQ9BXJ5.
    TreeFamiTF329591.

    Family and domain databases

    Gene3Di2.60.120.40. 1 hit.
    InterProiIPR001073. C1q.
    IPR008160. Collagen.
    IPR008983. Tumour_necrosis_fac-like_dom.
    [Graphical view]
    PfamiPF00386. C1q. 1 hit.
    PF01391. Collagen. 2 hits.
    [Graphical view]
    PRINTSiPR00007. COMPLEMNTC1Q.
    SMARTiSM00110. C1Q. 1 hit.
    [Graphical view]
    SUPFAMiSSF49842. SSF49842. 1 hit.
    PROSITEiPS50871. C1Q. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9BXJ5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MIPWVLLACA LPCAADPLLG AFARRDFRKG SPQLVCSLPG PQGPPGPPGA    50
    PGPSGMMGRM GFPGKDGQDG HDGDRGDSGE EGPPGRTGNR GKPGPKGKAG 100
    AIGRAGPRGP KGVNGTPGKH GTPGKKGPKG KKGEPGLPGP CSCGSGHTKS 150
    AFSVAVTKSY PRERLPIKFD KILMNEGGHY NASSGKFVCG VPGIYYFTYD 200
    ITLANKHLAI GLVHNGQYRI RTFDANTGNH DVASGSTILA LKQGDEVWLQ 250
    IFYSEQNGLF YDPYWTDSLF TGFLIYADQD DPNEV 285
    Length:285
    Mass (Da):29,952
    Last modified:June 1, 2001 - v1
    Checksum:i7E31FF9868D4EDFA
    GO

    Sequence cautioni

    The sequence AAH11699.2 differs from that shown. Reason: Erroneous initiation.
    The sequence AAH54506.2 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF329836 mRNA. Translation: AAK17960.1.
    AY358839 mRNA. Translation: AAQ89198.1.
    AC091842 Genomic DNA. No translation available.
    AC112191 Genomic DNA. No translation available.
    BC011699 mRNA. Translation: AAH11699.2. Different initiation.
    BC054506 mRNA. Translation: AAH54506.2. Different initiation.
    RefSeqiNP_114114.2. NM_031908.4.
    UniGeneiHs.110062.

    Genome annotation databases

    EnsembliENST00000393975; ENSP00000377545; ENSG00000145861.
    GeneIDi114898.
    KEGGihsa:114898.
    UCSCiuc003lyd.3. human.

    Polymorphism databases

    DMDMi20177866.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF329836 mRNA. Translation: AAK17960.1 .
    AY358839 mRNA. Translation: AAQ89198.1 .
    AC091842 Genomic DNA. No translation available.
    AC112191 Genomic DNA. No translation available.
    BC011699 mRNA. Translation: AAH11699.2 . Different initiation.
    BC054506 mRNA. Translation: AAH54506.2 . Different initiation.
    RefSeqi NP_114114.2. NM_031908.4.
    UniGenei Hs.110062.

    3D structure databases

    ProteinModelPortali Q9BXJ5.
    SMRi Q9BXJ5. Positions 150-275.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q9BXJ5. 1 interaction.

    PTM databases

    PhosphoSitei Q9BXJ5.

    Polymorphism databases

    DMDMi 20177866.

    Proteomic databases

    PaxDbi Q9BXJ5.
    PRIDEi Q9BXJ5.

    Protocols and materials databases

    DNASUi 114898.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000393975 ; ENSP00000377545 ; ENSG00000145861 .
    GeneIDi 114898.
    KEGGi hsa:114898.
    UCSCi uc003lyd.3. human.

    Organism-specific databases

    CTDi 114898.
    GeneCardsi GC05M159707.
    H-InvDB HIX0005376.
    HGNCi HGNC:14325. C1QTNF2.
    HPAi HPA061290.
    neXtProti NX_Q9BXJ5.
    PharmGKBi PA25629.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG121676.
    HOGENOMi HOG000085653.
    HOVERGENi HBG108220.
    InParanoidi Q9BXJ5.
    OrthoDBi EOG70ZZPW.
    PhylomeDBi Q9BXJ5.
    TreeFami TF329591.

    Miscellaneous databases

    GenomeRNAii 114898.
    NextBioi 79402.
    PROi Q9BXJ5.

    Gene expression databases

    Bgeei Q9BXJ5.
    CleanExi HS_C1QTNF2.
    Genevestigatori Q9BXJ5.

    Family and domain databases

    Gene3Di 2.60.120.40. 1 hit.
    InterProi IPR001073. C1q.
    IPR008160. Collagen.
    IPR008983. Tumour_necrosis_fac-like_dom.
    [Graphical view ]
    Pfami PF00386. C1q. 1 hit.
    PF01391. Collagen. 2 hits.
    [Graphical view ]
    PRINTSi PR00007. COMPLEMNTC1Q.
    SMARTi SM00110. C1Q. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49842. SSF49842. 1 hit.
    PROSITEi PS50871. C1Q. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Homo sapiens complement-c1q tumor necrosis factor-related protein."
      Piddington C.S., Bishop P.
      Submitted (DEC-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    3. "The DNA sequence and comparative analysis of human chromosome 5."
      Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.
      , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
      Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain and Muscle.

    Entry informationi

    Entry nameiC1QT2_HUMAN
    AccessioniPrimary (citable) accession number: Q9BXJ5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 16, 2002
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 110 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 5
      Human chromosome 5: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3