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Protein

Complement C1q tumor necrosis factor-related protein 2

Gene

C1QTNF2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Complement C1q tumor necrosis factor-related protein 2
Gene namesi
Name:C1QTNF2
Synonyms:CTRP2
ORF Names:UNQ6349/PRO21054
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000145861.7.
HGNCiHGNC:14325. C1QTNF2.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA25629.

Polymorphism and mutation databases

DMDMi20177866.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 15Sequence analysisAdd BLAST15
ChainiPRO_000000353016 – 285Complement C1q tumor necrosis factor-related protein 2Add BLAST270

Proteomic databases

EPDiQ9BXJ5.
PaxDbiQ9BXJ5.
PeptideAtlasiQ9BXJ5.
PRIDEiQ9BXJ5.

PTM databases

iPTMnetiQ9BXJ5.
PhosphoSitePlusiQ9BXJ5.

Expressioni

Gene expression databases

BgeeiENSG00000145861.
CleanExiHS_C1QTNF2.
GenevisibleiQ9BXJ5. HS.

Interactioni

Subunit structurei

May interact with ERFE.By similarity

Binary interactionsi

Show more details

GO - Molecular functioni

Protein-protein interaction databases

BioGridi125389. 30 interactors.
IntActiQ9BXJ5. 10 interactors.
STRINGi9606.ENSP00000377545.

Structurei

3D structure databases

ProteinModelPortaliQ9BXJ5.
SMRiQ9BXJ5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini40 – 141Collagen-likeAdd BLAST102
Domaini145 – 281C1qPROSITE-ProRule annotationAdd BLAST137

Keywords - Domaini

Collagen, Signal

Phylogenomic databases

eggNOGiENOG410IEVW. Eukaryota.
ENOG410XQXK. LUCA.
HOGENOMiHOG000085653.
HOVERGENiHBG108220.
InParanoidiQ9BXJ5.
OrthoDBiEOG091G0L3Y.
PhylomeDBiQ9BXJ5.
TreeFamiTF329591.

Family and domain databases

Gene3Di2.160.20.50. 2 hits.
2.60.120.40. 1 hit.
InterProiView protein in InterPro
IPR001073. C1q_dom.
IPR008160. Collagen.
IPR016133. Insect_cyst_antifreeze_prot.
IPR008983. Tumour_necrosis_fac-like_dom.
PfamiView protein in Pfam
PF00386. C1q. 1 hit.
PF01391. Collagen. 2 hits.
PRINTSiPR00007. COMPLEMNTC1Q.
SMARTiView protein in SMART
SM00110. C1Q. 1 hit.
SUPFAMiSSF49842. SSF49842. 1 hit.
PROSITEiView protein in PROSITE
PS50871. C1Q. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9BXJ5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIPWVLLACA LPCAADPLLG AFARRDFRKG SPQLVCSLPG PQGPPGPPGA
60 70 80 90 100
PGPSGMMGRM GFPGKDGQDG HDGDRGDSGE EGPPGRTGNR GKPGPKGKAG
110 120 130 140 150
AIGRAGPRGP KGVNGTPGKH GTPGKKGPKG KKGEPGLPGP CSCGSGHTKS
160 170 180 190 200
AFSVAVTKSY PRERLPIKFD KILMNEGGHY NASSGKFVCG VPGIYYFTYD
210 220 230 240 250
ITLANKHLAI GLVHNGQYRI RTFDANTGNH DVASGSTILA LKQGDEVWLQ
260 270 280
IFYSEQNGLF YDPYWTDSLF TGFLIYADQD DPNEV
Length:285
Mass (Da):29,952
Last modified:June 1, 2001 - v1
Checksum:i7E31FF9868D4EDFA
GO

Sequence cautioni

Q9BXJ5: The sequence AAH11699 differs from that shown. Reason: Erroneous initiation.Curated
Q9BXJ5: The sequence AAH54506 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF329836 mRNA. Translation: AAK17960.1.
AY358839 mRNA. Translation: AAQ89198.1.
AC091842 Genomic DNA. No translation available.
AC112191 Genomic DNA. No translation available.
BC011699 mRNA. Translation: AAH11699.2. Different initiation.
BC054506 mRNA. Translation: AAH54506.2. Different initiation.
RefSeqiNP_114114.2. NM_031908.4.
UniGeneiHs.110062.

Genome annotation databases

EnsembliENST00000393975; ENSP00000377545; ENSG00000145861.
GeneIDi114898.
KEGGihsa:114898.
UCSCiuc003lyd.4. human.

Similar proteinsi

Entry informationi

Entry nameiC1QT2_HUMAN
AccessioniPrimary (citable) accession number: Q9BXJ5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 16, 2002
Last sequence update: June 1, 2001
Last modified: October 25, 2017
This is version 133 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM