Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q9BXJ5 (C1QT2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 109. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Complement C1q tumor necrosis factor-related protein 2
Gene names
Name:C1QTNF2
Synonyms:CTRP2
ORF Names:UNQ6349/PRO21054
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length285 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Subunit structure

May interact with FAM132B By similarity.

Subcellular location

Secreted Potential.

Sequence similarities

Contains 1 C1q domain.

Contains 1 collagen-like domain.

Sequence caution

The sequence AAH11699.2 differs from that shown. Reason: Erroneous initiation.

The sequence AAH54506.2 differs from that shown. Reason: Erroneous initiation.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1515 Potential
Chain16 – 285270Complement C1q tumor necrosis factor-related protein 2
PRO_0000003530

Regions

Domain40 – 141102Collagen-like
Domain145 – 281137C1q

Sequences

Sequence LengthMass (Da)Tools
Q9BXJ5 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: 7E31FF9868D4EDFA

FASTA28529,952
        10         20         30         40         50         60 
MIPWVLLACA LPCAADPLLG AFARRDFRKG SPQLVCSLPG PQGPPGPPGA PGPSGMMGRM 

        70         80         90        100        110        120 
GFPGKDGQDG HDGDRGDSGE EGPPGRTGNR GKPGPKGKAG AIGRAGPRGP KGVNGTPGKH 

       130        140        150        160        170        180 
GTPGKKGPKG KKGEPGLPGP CSCGSGHTKS AFSVAVTKSY PRERLPIKFD KILMNEGGHY 

       190        200        210        220        230        240 
NASSGKFVCG VPGIYYFTYD ITLANKHLAI GLVHNGQYRI RTFDANTGNH DVASGSTILA 

       250        260        270        280 
LKQGDEVWLQ IFYSEQNGLF YDPYWTDSLF TGFLIYADQD DPNEV 

« Hide

References

« Hide 'large scale' references
[1]"Homo sapiens complement-c1q tumor necrosis factor-related protein."
Piddington C.S., Bishop P.
Submitted (DEC-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. expand/collapse author list , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.
Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]"The DNA sequence and comparative analysis of human chromosome 5."
Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S. expand/collapse author list , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain and Muscle.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF329836 mRNA. Translation: AAK17960.1.
AY358839 mRNA. Translation: AAQ89198.1.
AC091842 Genomic DNA. No translation available.
AC112191 Genomic DNA. No translation available.
BC011699 mRNA. Translation: AAH11699.2. Different initiation.
BC054506 mRNA. Translation: AAH54506.2. Different initiation.
RefSeqNP_114114.2. NM_031908.4.
UniGeneHs.110062.

3D structure databases

ProteinModelPortalQ9BXJ5.
SMRQ9BXJ5. Positions 150-275.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ9BXJ5. 1 interaction.

PTM databases

PhosphoSiteQ9BXJ5.

Polymorphism databases

DMDM20177866.

Proteomic databases

PaxDbQ9BXJ5.
PRIDEQ9BXJ5.

Protocols and materials databases

DNASU114898.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000393975; ENSP00000377545; ENSG00000145861.
GeneID114898.
KEGGhsa:114898.
UCSCuc003lyd.3. human.

Organism-specific databases

CTD114898.
GeneCardsGC05M159707.
H-InvDBHIX0005376.
HGNCHGNC:14325. C1QTNF2.
HPAHPA061290.
neXtProtNX_Q9BXJ5.
PharmGKBPA25629.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG121676.
HOGENOMHOG000085653.
HOVERGENHBG108220.
InParanoidQ9BXJ5.
OrthoDBEOG70ZZPW.
PhylomeDBQ9BXJ5.
TreeFamTF329591.

Gene expression databases

BgeeQ9BXJ5.
CleanExHS_C1QTNF2.
GenevestigatorQ9BXJ5.

Family and domain databases

Gene3D2.60.120.40. 1 hit.
InterProIPR001073. C1q.
IPR008160. Collagen.
IPR008983. Tumour_necrosis_fac-like_dom.
[Graphical view]
PfamPF00386. C1q. 1 hit.
PF01391. Collagen. 2 hits.
[Graphical view]
PRINTSPR00007. COMPLEMNTC1Q.
SMARTSM00110. C1Q. 1 hit.
[Graphical view]
SUPFAMSSF49842. SSF49842. 1 hit.
PROSITEPS50871. C1Q. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi114898.
NextBio79402.
PROQ9BXJ5.

Entry information

Entry nameC1QT2_HUMAN
AccessionPrimary (citable) accession number: Q9BXJ5
Entry history
Integrated into UniProtKB/Swiss-Prot: April 16, 2002
Last sequence update: June 1, 2001
Last modified: July 9, 2014
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human chromosome 5

Human chromosome 5: entries, gene names and cross-references to MIM