Reviewed, UniProtKB/Swiss-Prot Q9BXJ5 (C1QT2_HUMAN)

Names and origin

Protein names

Recommended name:
    Complement C1q tumor necrosis factor-related protein 2

Gene names

Name:	C1QTNF2
Synonyms:	CTRP2
ORF Names:	UNQ6349/PRO21054

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	285 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Subcellular location	Secreted Potential.
Sequence similarities	Contains 1 C1q domain. Contains 1 collagen-like domain.

Ontologies

Keywords
Cellular component	Secreted
Domain	Collagen Signal
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 15	15	Potential
	Chain	16 – 285	270	Complement C1q tumor necrosis factor-related protein 2		PRO_0000003530
Regions
	Domain	40 – 141	102	Collagen-like
	Domain	145 – 285	141	C1q

Sequences

	Sequence		Length	Mass (Da)
	Q9BXJ5-1 [UniParc]. Last modified June 1, 2001. Version 1. Checksum: 7E31FF9868D4EDFA	FASTA	285	29,952
	10 20 30 40 50 60 MIPWVLLACA LPCAADPLLG AFARRDFRKG SPQLVCSLPG PQGPPGPPGA PGPSGMMGRM 70 80 90 100 110 120 GFPGKDGQDG HDGDRGDSGE EGPPGRTGNR GKPGPKGKAG AIGRAGPRGP KGVNGTPGKH 130 140 150 160 170 180 GTPGKKGPKG KKGEPGLPGP CSCGSGHTKS AFSVAVTKSY PRERLPIKFD KILMNEGGHY 190 200 210 220 230 240 NASSGKFVCG VPGIYYFTYD ITLANKHLAI GLVHNGQYRI RTFDANTGNH DVASGSTILA 250 260 270 280 LKQGDEVWLQ IFYSEQNGLF YDPYWTDSLF TGFLIYADQD DPNEV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Homo sapiens complement-c1q tumor necrosis factor-related protein." Piddington C.S., Bishop P. Submitted (DEC-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M. Genome Res. 13:2265-2270(2003) [PubMed: 12975309] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]	"The DNA sequence and comparative analysis of human chromosome 5." Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S. , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M. Nature 431:268-274(2004) [PubMed: 15372022] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain and Muscle.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF329836 mRNA. Translation: AAK17960.1. AY358839 mRNA. Translation: AAQ89198.1. AC091842 Genomic DNA. No translation available. AC112191 Genomic DNA. No translation available. BC011699 mRNA. Translation: AAH11699.1. BC054506 mRNA. Translation: AAH54506.1.
IPI	IPI00873947.
RefSeq	NP_114114.2.
UniGene	Hs.110062
3D structure databases
HSSP	HSSP built from PDB template 1C28 based on UniProtKB Q60994.
ModBase	Search...
Proteomic databases
PRIDE	Q9BXJ5.
Genome annotation databases
Ensembl	ENSG00000145861. Homo sapiens. [Contig view]
GeneID	114898.
KEGG	hsa:114898.
Organism-specific databases
GeneCards	GC05M159707.
H-InvDB	HIX0005376.
HGNC	HGNC:14325. C1QTNF2.
PharmGKB	PA25629.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	Q9BXJ5.
HOVERGEN	Q9BXJ5.
Gene expression databases
ArrayExpress	Q9BXJ5.
Bgee	Q9BXJ5.
CleanEx	HS_C1QTNF2.
GermOnline	ENSG00000145861. Homo sapiens.
Family and domain databases
InterPro	IPR001073. C1q. IPR008160. Collagen. IPR008983. Tumour_necrosis_fac-like. [Graphical view]
Gene3D	G3DSA:2.60.120.40. Tumour_necrosis_fac-like. 1 hit.
Pfam	PF00386. C1q. 1 hit. PF01391. Collagen. 2 hits. [Graphical view]
PRINTS	PR00007. COMPLEMNTC1Q.
SMART	SM00110. C1Q. 1 hit. [Graphical view]
PROSITE	PS50871. C1Q. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	79402.

Entry information

Entry name

C1QT2_HUMAN

Accession

Primary (citable) accession number: Q9BXJ5

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 16, 2002
Last sequence update:	June 1, 2001
Last modified:	June 16, 2009
This is version 69 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)