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Protein

Complement C1q tumor necrosis factor-related protein 3

Gene

C1QTNF3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

  • cellular triglyceride homeostasis Source: UniProtKB
  • fat cell differentiation Source: UniProtKB
  • negative regulation of gene expression Source: UniProtKB
  • negative regulation of gluconeogenesis Source: UniProtKB
  • negative regulation of inflammatory response Source: UniProtKB
  • negative regulation of interleukin-6 secretion Source: UniProtKB
  • negative regulation of monocyte chemotactic protein-1 production Source: UniProtKB
  • negative regulation of NF-kappaB import into nucleus Source: UniProtKB
  • positive regulation of adiponectin secretion Source: UniProtKB
  • positive regulation of cytokine secretion Source: UniProtKB
  • protein trimerization Source: UniProtKB

Names & Taxonomyi

Protein namesi
Recommended name:
Complement C1q tumor necrosis factor-related protein 3
Alternative name(s):
Collagenous repeat-containing sequence 26 kDa protein
Short name:
CORS26
Secretory protein CORS26
Gene namesi
Name:C1QTNF3
Synonyms:CTRP3
ORF Names:UNQ753/PRO1484
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000082196.20.
HGNCiHGNC:14326. C1QTNF3.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi114899.
OpenTargetsiENSG00000082196.
PharmGKBiPA25630.

Polymorphism and mutation databases

BioMutaiC1QTNF3.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000000353123 – 246Complement C1q tumor necrosis factor-related protein 3Add BLAST224

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Isoform 3 (identifier: Q9BXJ4-3)
Glycosylationi70N-linked (GlcNAc...) asparagine1

Post-translational modificationi

Isoform 3: Glycosylated on Asn-70.

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9BXJ4.
PeptideAtlasiQ9BXJ4.
PRIDEiQ9BXJ4.

PTM databases

iPTMnetiQ9BXJ4.
PhosphoSitePlusiQ9BXJ4.

Expressioni

Tissue specificityi

Expressed in colon and small intestine.1 Publication

Gene expression databases

BgeeiENSG00000082196.
CleanExiHS_C1QTNF3.
GenevisibleiQ9BXJ4. HS.

Organism-specific databases

HPAiHPA064996.
HPA066011.

Interactioni

Protein-protein interaction databases

BioGridi125390. 2 interactors.
IntActiQ9BXJ4. 1 interactor.
STRINGi9606.ENSP00000371497.

Structurei

3D structure databases

ProteinModelPortaliQ9BXJ4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini51 – 113Collagen-likeAdd BLAST63
Domaini113 – 246C1qPROSITE-ProRule annotationAdd BLAST134

Keywords - Domaini

Collagen, Signal

Phylogenomic databases

eggNOGiENOG410IJ69. Eukaryota.
ENOG410Y296. LUCA.
GeneTreeiENSGT00760000119052.
HOGENOMiHOG000085658.
HOVERGENiHBG108220.
InParanoidiQ9BXJ4.
OMAiLYSYESK.
OrthoDBiEOG091G0UOF.
PhylomeDBiQ9BXJ4.
TreeFamiTF329591.

Family and domain databases

Gene3Di2.160.20.50. 1 hit.
2.60.120.40. 1 hit.
InterProiView protein in InterPro
IPR001073. C1q_dom.
IPR008160. Collagen.
IPR016133. Insect_cyst_antifreeze_prot.
IPR008983. Tumour_necrosis_fac-like_dom.
PfamiView protein in Pfam
PF00386. C1q. 1 hit.
PF01391. Collagen. 1 hit.
PRINTSiPR00007. COMPLEMNTC1Q.
SMARTiView protein in SMART
SM00110. C1Q. 1 hit.
SUPFAMiSSF49842. SSF49842. 1 hit.
PROSITEiView protein in PROSITE
PS50871. C1Q. 1 hit.

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9BXJ4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLWRQLIYWQ LLALFFLPFC LCQDEYMESP QTGGLPPDCS KCCHGDYSFR
60 70 80 90 100
GYQGPPGPPG PPGIPGNHGN NGNNGATGHE GAKGEKGDKG DLGPRGERGQ
110 120 130 140 150
HGPKGEKGYP GIPPELQIAF MASLATHFSN QNSGIIFSSV ETNIGNFFDV
160 170 180 190 200
MTGRFGAPVS GVYFFTFSMM KHEDVEEVYV YLMHNGNTVF SMYSYEMKGK
210 220 230 240
SDTSSNHAVL KLAKGDEVWL RMGNGALHGD HQRFSTFAGF LLFETK
Length:246
Mass (Da):26,994
Last modified:June 1, 2001 - v1
Checksum:iC589B6C3A73E5D29
GO
Isoform 2 (identifier: Q9BXJ4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     46-69: Missing.
     82-105: Missing.

Note: No experimental confirmation available.
Show »
Length:198
Mass (Da):22,177
Checksum:iAC84CC13912ED445
GO
Isoform 3 (identifier: Q9BXJ4-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     28-28: E → EVSGRTNKVVARIVQSHQQTGRSGSRREKVRERSHPKTGTVDNNTSTDLKSLRPDELPHPEVDDLAQITTFWGQ

Show »
Length:319
Mass (Da):35,183
Checksum:iEC12962E5B726F00
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04315728E → EVSGRTNKVVARIVQSHQQT GRSGSRREKVRERSHPKTGT VDNNTSTDLKSLRPDELPHP EVDDLAQITTFWGQ in isoform 3. 3 Publications1
Alternative sequenceiVSP_01162446 – 69Missing in isoform 2. 1 PublicationAdd BLAST24
Alternative sequenceiVSP_01162582 – 105Missing in isoform 2. 1 PublicationAdd BLAST24

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF329837 mRNA. Translation: AAK17961.1.
AF326976 mRNA. Translation: AAK70344.1.
EU399231 mRNA. Translation: ABY86416.1.
EU399232 mRNA. Translation: ABY86417.1.
AY358388 mRNA. Translation: AAQ88754.1.
AK295968 mRNA. Translation: BAG58744.1.
AK315921 mRNA. Translation: BAH14292.1.
AK075533 mRNA. Translation: BAC11676.1.
BX640995 mRNA. Translation: CAE45998.1.
AC139783 Genomic DNA. No translation available.
AC139792 Genomic DNA. No translation available.
CH471118 Genomic DNA. Translation: EAX10820.1.
BC112925 mRNA. Translation: AAI12926.1.
BC120990 mRNA. Translation: AAI20991.1.
AF173888 mRNA. Translation: AAQ13635.1.
CCDSiCCDS34141.1. [Q9BXJ4-3]
CCDS3904.1. [Q9BXJ4-1]
RefSeqiNP_112207.1. NM_030945.3. [Q9BXJ4-1]
NP_852100.3. NM_181435.5. [Q9BXJ4-3]
UniGeneiHs.171929.

Genome annotation databases

EnsembliENST00000231338; ENSP00000231338; ENSG00000082196. [Q9BXJ4-1]
ENST00000382065; ENSP00000371497; ENSG00000082196. [Q9BXJ4-3]
GeneIDi114899.
KEGGihsa:114899.
UCSCiuc003jin.4. human. [Q9BXJ4-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiC1QT3_HUMAN
AccessioniPrimary (citable) accession number: Q9BXJ4
Secondary accession number(s): Q0VAN4
, Q542Y2, Q6MZN1, Q96KY1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 16, 2002
Last sequence update: June 1, 2001
Last modified: October 25, 2017
This is version 140 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot