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Protein

Complement C1q tumor necrosis factor-related protein 4

Gene

C1QTNF4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May act as a pro-inflammatory cytokine, that induces the activation of NF-kappa-B signaling pathway and up-regulates IL6 production.1 Publication

Keywords - Molecular functioni

Cytokine

Names & Taxonomyi

Protein namesi
Recommended name:
Complement C1q tumor necrosis factor-related protein 4
Gene namesi
Name:C1QTNF4
Synonyms:CTRP4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:14346. C1QTNF4.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA25631.

Polymorphism and mutation databases

BioMutaiC1QTNF4.
DMDMi116241274.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 16161 PublicationAdd
BLAST
Chaini17 – 329313Complement C1q tumor necrosis factor-related protein 4PRO_0000003533Add
BLAST

Proteomic databases

EPDiQ9BXJ3.
PaxDbiQ9BXJ3.
PeptideAtlasiQ9BXJ3.
PRIDEiQ9BXJ3.

PTM databases

iPTMnetiQ9BXJ3.
PhosphoSiteiQ9BXJ3.

Expressioni

Tissue specificityi

Widely expressed at low levels.1 Publication

Inductioni

Up-regulated by IL6.1 Publication

Gene expression databases

BgeeiQ9BXJ3.
CleanExiHS_C1QTNF4.
ExpressionAtlasiQ9BXJ3. baseline and differential.
GenevisibleiQ9BXJ3. HS.

Organism-specific databases

HPAiHPA041032.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000302274.

Structurei

3D structure databases

ProteinModelPortaliQ9BXJ3.
SMRiQ9BXJ3. Positions 28-317.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini25 – 162138C1q 1PROSITE-ProRule annotationAdd
BLAST
Domaini172 – 317146C1q 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 2 C1q domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IFAJ. Eukaryota.
ENOG4111IFJ. LUCA.
GeneTreeiENSGT00760000118830.
HOGENOMiHOG000072708.
HOVERGENiHBG050752.
InParanoidiQ9BXJ3.
OMAiQHDGYGA.
OrthoDBiEOG70ZZPW.
PhylomeDBiQ9BXJ3.
TreeFamiTF329591.

Family and domain databases

Gene3Di2.60.120.40. 2 hits.
InterProiIPR001073. C1q_dom.
IPR008983. Tumour_necrosis_fac-like_dom.
[Graphical view]
PfamiPF00386. C1q. 2 hits.
[Graphical view]
PRINTSiPR00007. COMPLEMNTC1Q.
SMARTiSM00110. C1Q. 2 hits.
[Graphical view]
SUPFAMiSSF49842. SSF49842. 2 hits.
PROSITEiPS50871. C1Q. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9BXJ3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLPLLLGLLG PAACWALGPT PGPGSSELRS AFSAARTTPL EGTSEMAVTF
60 70 80 90 100
DKVYVNIGGD FDVATGQFRC RVPGAYFFSF TAGKAPHKSL SVMLVRNRDE
110 120 130 140 150
VQALAFDEQR RPGARRAASQ SAMLQLDYGD TVWLRLHGAP QYALGAPGAT
160 170 180 190 200
FSGYLVYADA DADAPARGPP APPEPRSAFS AARTRSLVGS DAGPGPRHQP
210 220 230 240 250
LAFDTEFVNI GGDFDAAAGV FRCRLPGAYF FSFTLGKLPR KTLSVKLMKN
260 270 280 290 300
RDEVQAMIYD DGASRRREMQ SQSVMLALRR GDAVWLLSHD HDGYGAYSNH
310 320
GKYITFSGFL VYPDLAPAAP PGLGASELL
Length:329
Mass (Da):35,256
Last modified:October 17, 2006 - v2
Checksum:i16064DA8182A6732
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti141 – 1411Q → H in AAK17962 (Ref. 1) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF329838 mRNA. Translation: AAK17962.1.
BC035628 mRNA. Translation: AAH35628.1.
CCDSiCCDS7942.1.
RefSeqiNP_114115.2. NM_031909.2.
UniGeneiHs.662633.

Genome annotation databases

EnsembliENST00000302514; ENSP00000302274; ENSG00000172247.
GeneIDi114900.
KEGGihsa:114900.
UCSCiuc001ngc.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF329838 mRNA. Translation: AAK17962.1.
BC035628 mRNA. Translation: AAH35628.1.
CCDSiCCDS7942.1.
RefSeqiNP_114115.2. NM_031909.2.
UniGeneiHs.662633.

3D structure databases

ProteinModelPortaliQ9BXJ3.
SMRiQ9BXJ3. Positions 28-317.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000302274.

PTM databases

iPTMnetiQ9BXJ3.
PhosphoSiteiQ9BXJ3.

Polymorphism and mutation databases

BioMutaiC1QTNF4.
DMDMi116241274.

Proteomic databases

EPDiQ9BXJ3.
PaxDbiQ9BXJ3.
PeptideAtlasiQ9BXJ3.
PRIDEiQ9BXJ3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000302514; ENSP00000302274; ENSG00000172247.
GeneIDi114900.
KEGGihsa:114900.
UCSCiuc001ngc.3. human.

Organism-specific databases

CTDi114900.
GeneCardsiC1QTNF4.
HGNCiHGNC:14346. C1QTNF4.
HPAiHPA041032.
MIMi614911. gene.
neXtProtiNX_Q9BXJ3.
PharmGKBiPA25631.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IFAJ. Eukaryota.
ENOG4111IFJ. LUCA.
GeneTreeiENSGT00760000118830.
HOGENOMiHOG000072708.
HOVERGENiHBG050752.
InParanoidiQ9BXJ3.
OMAiQHDGYGA.
OrthoDBiEOG70ZZPW.
PhylomeDBiQ9BXJ3.
TreeFamiTF329591.

Miscellaneous databases

GenomeRNAii114900.
PROiQ9BXJ3.
SOURCEiSearch...

Gene expression databases

BgeeiQ9BXJ3.
CleanExiHS_C1QTNF4.
ExpressionAtlasiQ9BXJ3. baseline and differential.
GenevisibleiQ9BXJ3. HS.

Family and domain databases

Gene3Di2.60.120.40. 2 hits.
InterProiIPR001073. C1q_dom.
IPR008983. Tumour_necrosis_fac-like_dom.
[Graphical view]
PfamiPF00386. C1q. 2 hits.
[Graphical view]
PRINTSiPR00007. COMPLEMNTC1Q.
SMARTiSM00110. C1Q. 2 hits.
[Graphical view]
SUPFAMiSSF49842. SSF49842. 2 hits.
PROSITEiPS50871. C1Q. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Homo sapiens complement-c1q tumor necrosis factor-related protein."
    Holloway J.L., Lok S.
    Submitted (DEC-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  3. "Identification of C1qTNF-related protein 4 as a potential cytokine that stimulates the STAT3 and NF-kappaB pathways and promotes cell survival in human cancer cells."
    Li Q., Wang L., Tan W., Peng Z., Luo Y., Zhang Y., Zhang G., Na D., Jin P., Shi T., Ma D., Wang L.
    Cancer Lett. 308:203-214(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF N-TERMINUS, FUNCTION, SUBCELLULAR LOCATION, INDUCTION, TISSUE SPECIFICITY.

Entry informationi

Entry nameiC1QT4_HUMAN
AccessioniPrimary (citable) accession number: Q9BXJ3
Secondary accession number(s): Q8IV25
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 16, 2002
Last sequence update: October 17, 2006
Last modified: July 6, 2016
This is version 113 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.