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Protein

Complement C1q tumor necrosis factor-related protein 7

Gene

C1QTNF7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Complement C1q tumor necrosis factor-related protein 7
Gene namesi
Name:C1QTNF7
Synonyms:CTRP7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:14342. C1QTNF7.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA25634.

Polymorphism and mutation databases

BioMutaiC1QTNF7.
DMDMi20177863.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1616Sequence analysisAdd
BLAST
Chaini17 – 289273Complement C1q tumor necrosis factor-related protein 7PRO_0000003539Add
BLAST

Proteomic databases

PaxDbiQ9BXJ2.
PeptideAtlasiQ9BXJ2.
PRIDEiQ9BXJ2.

PTM databases

iPTMnetiQ9BXJ2.
PhosphoSiteiQ9BXJ2.

Expressioni

Gene expression databases

BgeeiENSG00000163145.
CleanExiHS_C1QTNF7.
ExpressionAtlasiQ9BXJ2. baseline and differential.
GenevisibleiQ9BXJ2. HS.

Organism-specific databases

HPAiCAB007055.
HPA051797.

Interactioni

Protein-protein interaction databases

BioGridi125394. 1 interaction.
STRINGi9606.ENSP00000295297.

Structurei

3D structure databases

ProteinModelPortaliQ9BXJ2.
SMRiQ9BXJ2. Positions 148-273.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini38 – 139102Collagen-likeAdd
BLAST
Domaini143 – 279137C1qPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 C1q domain.PROSITE-ProRule annotation
Contains 1 collagen-like domain.Curated

Keywords - Domaini

Collagen, Signal

Phylogenomic databases

eggNOGiENOG410IFQ7. Eukaryota.
ENOG410ZWEM. LUCA.
GeneTreeiENSGT00760000118830.
HOGENOMiHOG000085653.
HOVERGENiHBG108220.
InParanoidiQ9BXJ2.
OMAiPRGNQFK.
OrthoDBiEOG091G0L3Y.
PhylomeDBiQ9BXJ2.

Family and domain databases

Gene3Di2.60.120.40. 1 hit.
InterProiIPR001073. C1q_dom.
IPR008160. Collagen.
IPR008983. Tumour_necrosis_fac-like_dom.
[Graphical view]
PfamiPF00386. C1q. 1 hit.
PF01391. Collagen. 2 hits.
[Graphical view]
PRINTSiPR00007. COMPLEMNTC1Q.
SMARTiSM00110. C1Q. 1 hit.
[Graphical view]
SUPFAMiSSF49842. SSF49842. 1 hit.
PROSITEiPS50871. C1Q. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9BXJ2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MFVLLYVTSF AICASGQPRG NQLKGENYSP RYICSIPGLP GPPGPPGANG
60 70 80 90 100
SPGPHGRIGL PGRDGRDGRK GEKGEKGTAG LRGKTGPLGL AGEKGDQGET
110 120 130 140 150
GKKGPIGPEG EKGEVGPIGP PGPKGDRGEQ GDPGLPGVCR CGSIVLKSAF
160 170 180 190 200
SVGITTSYPE ERLPIIFNKV LFNEGEHYNP ATGKFICAFP GIYYFSYDIT
210 220 230 240 250
LANKHLAIGL VHNGQYRIKT FDANTGNHDV ASGSTVIYLQ PEDEVWLEIF
260 270 280
FTDQNGLFSD PGWADSLFSG FLLYVDTDYL DSISEDDEL
Length:289
Mass (Da):30,683
Last modified:June 1, 2001 - v1
Checksum:iA61609FF86D26946
GO
Isoform 2 (identifier: Q9BXJ2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MSRQEPKM

Note: Gene prediction based on EST data.
Show »
Length:296
Mass (Da):31,540
Checksum:i019AB07DC066F8D0
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 11M → MSRQEPKM in isoform 2. 1 PublicationVSP_046778

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF329839 mRNA. Translation: AAK17963.1.
AK314802 mRNA. Translation: BAG37330.1.
BX647781 mRNA. No translation available.
AC007016 Genomic DNA. No translation available.
AC099550 Genomic DNA. No translation available.
BC022187 mRNA. Translation: AAH22187.1.
BC024015 mRNA. Translation: AAH24015.1.
CCDSiCCDS3414.1. [Q9BXJ2-1]
CCDS47025.1. [Q9BXJ2-2]
RefSeqiNP_001128642.1. NM_001135170.1. [Q9BXJ2-2]
NP_001128643.1. NM_001135171.1. [Q9BXJ2-1]
NP_114117.1. NM_031911.4. [Q9BXJ2-1]
XP_011512074.1. XM_011513772.1. [Q9BXJ2-2]
XP_011512075.1. XM_011513773.1. [Q9BXJ2-1]
UniGeneiHs.153714.

Genome annotation databases

EnsembliENST00000295297; ENSP00000295297; ENSG00000163145. [Q9BXJ2-2]
ENST00000429690; ENSP00000410722; ENSG00000163145. [Q9BXJ2-1]
ENST00000444304; ENSP00000388914; ENSG00000163145. [Q9BXJ2-1]
GeneIDi114905.
KEGGihsa:114905.
UCSCiuc003gno.4. human. [Q9BXJ2-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF329839 mRNA. Translation: AAK17963.1.
AK314802 mRNA. Translation: BAG37330.1.
BX647781 mRNA. No translation available.
AC007016 Genomic DNA. No translation available.
AC099550 Genomic DNA. No translation available.
BC022187 mRNA. Translation: AAH22187.1.
BC024015 mRNA. Translation: AAH24015.1.
CCDSiCCDS3414.1. [Q9BXJ2-1]
CCDS47025.1. [Q9BXJ2-2]
RefSeqiNP_001128642.1. NM_001135170.1. [Q9BXJ2-2]
NP_001128643.1. NM_001135171.1. [Q9BXJ2-1]
NP_114117.1. NM_031911.4. [Q9BXJ2-1]
XP_011512074.1. XM_011513772.1. [Q9BXJ2-2]
XP_011512075.1. XM_011513773.1. [Q9BXJ2-1]
UniGeneiHs.153714.

3D structure databases

ProteinModelPortaliQ9BXJ2.
SMRiQ9BXJ2. Positions 148-273.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125394. 1 interaction.
STRINGi9606.ENSP00000295297.

PTM databases

iPTMnetiQ9BXJ2.
PhosphoSiteiQ9BXJ2.

Polymorphism and mutation databases

BioMutaiC1QTNF7.
DMDMi20177863.

Proteomic databases

PaxDbiQ9BXJ2.
PeptideAtlasiQ9BXJ2.
PRIDEiQ9BXJ2.

Protocols and materials databases

DNASUi114905.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000295297; ENSP00000295297; ENSG00000163145. [Q9BXJ2-2]
ENST00000429690; ENSP00000410722; ENSG00000163145. [Q9BXJ2-1]
ENST00000444304; ENSP00000388914; ENSG00000163145. [Q9BXJ2-1]
GeneIDi114905.
KEGGihsa:114905.
UCSCiuc003gno.4. human. [Q9BXJ2-1]

Organism-specific databases

CTDi114905.
GeneCardsiC1QTNF7.
HGNCiHGNC:14342. C1QTNF7.
HPAiCAB007055.
HPA051797.
neXtProtiNX_Q9BXJ2.
PharmGKBiPA25634.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IFQ7. Eukaryota.
ENOG410ZWEM. LUCA.
GeneTreeiENSGT00760000118830.
HOGENOMiHOG000085653.
HOVERGENiHBG108220.
InParanoidiQ9BXJ2.
OMAiPRGNQFK.
OrthoDBiEOG091G0L3Y.
PhylomeDBiQ9BXJ2.

Miscellaneous databases

GenomeRNAii114905.
PROiQ9BXJ2.

Gene expression databases

BgeeiENSG00000163145.
CleanExiHS_C1QTNF7.
ExpressionAtlasiQ9BXJ2. baseline and differential.
GenevisibleiQ9BXJ2. HS.

Family and domain databases

Gene3Di2.60.120.40. 1 hit.
InterProiIPR001073. C1q_dom.
IPR008160. Collagen.
IPR008983. Tumour_necrosis_fac-like_dom.
[Graphical view]
PfamiPF00386. C1q. 1 hit.
PF01391. Collagen. 2 hits.
[Graphical view]
PRINTSiPR00007. COMPLEMNTC1Q.
SMARTiSM00110. C1Q. 1 hit.
[Graphical view]
SUPFAMiSSF49842. SSF49842. 1 hit.
PROSITEiPS50871. C1Q. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiC1QT7_HUMAN
AccessioniPrimary (citable) accession number: Q9BXJ2
Secondary accession number(s): B2RBT3, J3KPW3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 16, 2002
Last sequence update: June 1, 2001
Last modified: September 7, 2016
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.