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Protein

Complement C1q tumor necrosis factor-related protein 1

Gene

C1QTNF1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • collagen binding Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000173918-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Complement C1q tumor necrosis factor-related protein 1
Alternative name(s):
G protein-coupled receptor-interacting protein
Short name:
GIP
Gene namesi
Name:C1QTNF1
Synonyms:CTRP1
ORF Names:UNQ310/PRO353
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:14324. C1QTNF1.

Subcellular locationi

GO - Cellular componenti

  • collagen trimer Source: UniProtKB-KW
  • extracellular space Source: UniProtKB
  • integral component of plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi114897.
OpenTargetsiENSG00000173918.
PharmGKBiPA25628.

Polymorphism and mutation databases

BioMutaiC1QTNF1.
DMDMi20177862.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_000000352926 – 281Complement C1q tumor necrosis factor-related protein 1Add BLAST256

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi93N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9BXJ1.
PeptideAtlasiQ9BXJ1.
PRIDEiQ9BXJ1.

Expressioni

Gene expression databases

BgeeiENSG00000173918.
CleanExiHS_C1QTNF1.
ExpressionAtlasiQ9BXJ1. baseline and differential.
GenevisibleiQ9BXJ1. HS.

Organism-specific databases

HPAiCAB025429.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
LNX1Q8TBB13EBI-750200,EBI-739832
PRPF31F1T0A53EBI-750200,EBI-10177194
SGTAO437654EBI-750200,EBI-347996

GO - Molecular functioni

  • collagen binding Source: UniProtKB

Protein-protein interaction databases

BioGridi125388. 6 interactors.
IntActiQ9BXJ1. 6 interactors.
STRINGi9606.ENSP00000340864.

Structurei

3D structure databases

ProteinModelPortaliQ9BXJ1.
SMRiQ9BXJ1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini99 – 140Collagen-likeAdd BLAST42
Domaini141 – 281C1qPROSITE-ProRule annotationAdd BLAST141

Sequence similaritiesi

Contains 1 C1q domain.PROSITE-ProRule annotation
Contains 1 collagen-like domain.Curated

Keywords - Domaini

Collagen, Signal

Phylogenomic databases

eggNOGiENOG410IKX5. Eukaryota.
ENOG410XQIM. LUCA.
GeneTreeiENSGT00760000118830.
HOGENOMiHOG000101544.
HOVERGENiHBG108220.
InParanoidiQ9BXJ1.
OMAiLRCCDPG.
OrthoDBiEOG091G0LRA.
PhylomeDBiQ9BXJ1.
TreeFamiTF329591.

Family and domain databases

Gene3Di2.60.120.40. 1 hit.
InterProiIPR001073. C1q_dom.
IPR008160. Collagen.
IPR008983. Tumour_necrosis_fac-like_dom.
[Graphical view]
PfamiPF00386. C1q. 1 hit.
PF01391. Collagen. 1 hit.
[Graphical view]
PRINTSiPR00007. COMPLEMNTC1Q.
SMARTiSM00110. C1Q. 1 hit.
[Graphical view]
SUPFAMiSSF49842. SSF49842. 1 hit.
PROSITEiPS50871. C1Q. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9BXJ1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGSRGQGLLL AYCLLLAFAS GLVLSRVPHV QGEQQEWEGT EELPSPPDHA
60 70 80 90 100
ERAEEQHEKY RPSQDQGLPA SRCLRCCDPG TSMYPATAVP QINITILKGE
110 120 130 140 150
KGDRGDRGLQ GKYGKTGSAG ARGHTGPKGQ KGSMGAPGER CKSHYAAFSV
160 170 180 190 200
GRKKPMHSNH YYQTVIFDTE FVNLYDHFNM FTGKFYCYVP GLYFFSLNVH
210 220 230 240 250
TWNQKETYLH IMKNEEEVVI LFAQVGDRSI MQSQSLMLEL REQDQVWVRL
260 270 280
YKGERENAIF SEELDTYITF SGYLVKHATE P
Length:281
Mass (Da):31,743
Last modified:June 1, 2001 - v1
Checksum:i49E248CB88ACFB7C
GO
Isoform 2 (identifier: Q9BXJ1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MMSATGPGRKM

Note: No experimental confirmation available.
Show »
Length:291
Mass (Da):32,760
Checksum:i96A76F774212AB88
GO

Sequence cautioni

The sequence AAG44303 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAC20425 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti22L → P in CAC20425 (Ref. 1) Curated1
Sequence conflicti22L → P in AAG44303 (Ref. 1) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_068885241R → Q.1 PublicationCorresponds to variant rs35035542dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0555701M → MMSATGPGRKM in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ272138 mRNA. Translation: CAC20425.1. Different initiation.
AF232905 mRNA. Translation: AAG44303.1. Different initiation.
AF329840 mRNA. Translation: AAK17964.1.
AY358424 mRNA. Translation: AAQ88790.1.
AK055541 mRNA. Translation: BAB70947.1.
AK075175 mRNA. Translation: BAC11451.1.
AK172767 mRNA. Translation: BAD18750.1.
AC073624 Genomic DNA. No translation available.
BC021553 mRNA. Translation: AAH21553.1.
CCDSiCCDS11761.1. [Q9BXJ1-1]
RefSeqiNP_112230.1. NM_030968.3. [Q9BXJ1-1]
NP_699203.1. NM_153372.1. [Q9BXJ1-1]
NP_940995.1. NM_198593.3. [Q9BXJ1-1]
NP_940996.1. NM_198594.2.
XP_006721729.1. XM_006721666.1. [Q9BXJ1-2]
XP_016879615.1. XM_017024126.1.
UniGeneiHs.201398.
Hs.741602.

Genome annotation databases

EnsembliENST00000339142; ENSP00000340864; ENSG00000173918. [Q9BXJ1-1]
ENST00000354124; ENSP00000343230; ENSG00000173918. [Q9BXJ1-1]
ENST00000392445; ENSP00000376240; ENSG00000173918. [Q9BXJ1-1]
ENST00000579760; ENSP00000463922; ENSG00000173918. [Q9BXJ1-1]
ENST00000580454; ENSP00000462990; ENSG00000173918. [Q9BXJ1-1]
ENST00000580474; ENSP00000463108; ENSG00000173918. [Q9BXJ1-1]
ENST00000581774; ENSP00000462481; ENSG00000173918. [Q9BXJ1-1]
ENST00000583904; ENSP00000463008; ENSG00000173918. [Q9BXJ1-1]
GeneIDi114897.
KEGGihsa:114897.
UCSCiuc002jwp.5. human. [Q9BXJ1-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ272138 mRNA. Translation: CAC20425.1. Different initiation.
AF232905 mRNA. Translation: AAG44303.1. Different initiation.
AF329840 mRNA. Translation: AAK17964.1.
AY358424 mRNA. Translation: AAQ88790.1.
AK055541 mRNA. Translation: BAB70947.1.
AK075175 mRNA. Translation: BAC11451.1.
AK172767 mRNA. Translation: BAD18750.1.
AC073624 Genomic DNA. No translation available.
BC021553 mRNA. Translation: AAH21553.1.
CCDSiCCDS11761.1. [Q9BXJ1-1]
RefSeqiNP_112230.1. NM_030968.3. [Q9BXJ1-1]
NP_699203.1. NM_153372.1. [Q9BXJ1-1]
NP_940995.1. NM_198593.3. [Q9BXJ1-1]
NP_940996.1. NM_198594.2.
XP_006721729.1. XM_006721666.1. [Q9BXJ1-2]
XP_016879615.1. XM_017024126.1.
UniGeneiHs.201398.
Hs.741602.

3D structure databases

ProteinModelPortaliQ9BXJ1.
SMRiQ9BXJ1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125388. 6 interactors.
IntActiQ9BXJ1. 6 interactors.
STRINGi9606.ENSP00000340864.

Polymorphism and mutation databases

BioMutaiC1QTNF1.
DMDMi20177862.

Proteomic databases

PaxDbiQ9BXJ1.
PeptideAtlasiQ9BXJ1.
PRIDEiQ9BXJ1.

Protocols and materials databases

DNASUi114897.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000339142; ENSP00000340864; ENSG00000173918. [Q9BXJ1-1]
ENST00000354124; ENSP00000343230; ENSG00000173918. [Q9BXJ1-1]
ENST00000392445; ENSP00000376240; ENSG00000173918. [Q9BXJ1-1]
ENST00000579760; ENSP00000463922; ENSG00000173918. [Q9BXJ1-1]
ENST00000580454; ENSP00000462990; ENSG00000173918. [Q9BXJ1-1]
ENST00000580474; ENSP00000463108; ENSG00000173918. [Q9BXJ1-1]
ENST00000581774; ENSP00000462481; ENSG00000173918. [Q9BXJ1-1]
ENST00000583904; ENSP00000463008; ENSG00000173918. [Q9BXJ1-1]
GeneIDi114897.
KEGGihsa:114897.
UCSCiuc002jwp.5. human. [Q9BXJ1-1]

Organism-specific databases

CTDi114897.
DisGeNETi114897.
GeneCardsiC1QTNF1.
HGNCiHGNC:14324. C1QTNF1.
HPAiCAB025429.
MIMi610365. gene.
neXtProtiNX_Q9BXJ1.
OpenTargetsiENSG00000173918.
PharmGKBiPA25628.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IKX5. Eukaryota.
ENOG410XQIM. LUCA.
GeneTreeiENSGT00760000118830.
HOGENOMiHOG000101544.
HOVERGENiHBG108220.
InParanoidiQ9BXJ1.
OMAiLRCCDPG.
OrthoDBiEOG091G0LRA.
PhylomeDBiQ9BXJ1.
TreeFamiTF329591.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000173918-MONOMER.

Miscellaneous databases

ChiTaRSiC1QTNF1. human.
GeneWikiiC1QTNF1.
GenomeRNAii114897.
PROiQ9BXJ1.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000173918.
CleanExiHS_C1QTNF1.
ExpressionAtlasiQ9BXJ1. baseline and differential.
GenevisibleiQ9BXJ1. HS.

Family and domain databases

Gene3Di2.60.120.40. 1 hit.
InterProiIPR001073. C1q_dom.
IPR008160. Collagen.
IPR008983. Tumour_necrosis_fac-like_dom.
[Graphical view]
PfamiPF00386. C1q. 1 hit.
PF01391. Collagen. 1 hit.
[Graphical view]
PRINTSiPR00007. COMPLEMNTC1Q.
SMARTiSM00110. C1Q. 1 hit.
[Graphical view]
SUPFAMiSSF49842. SSF49842. 1 hit.
PROSITEiPS50871. C1Q. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiC1QT1_HUMAN
AccessioniPrimary (citable) accession number: Q9BXJ1
Secondary accession number(s): Q6ZMH6, Q96NF2, Q9GZR4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 16, 2002
Last sequence update: June 1, 2001
Last modified: November 30, 2016
This is version 137 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.