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Q9BXJ1 (C1QT1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 92. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Complement C1q tumor necrosis factor-related protein 1
Alternative name(s):
G protein-coupled receptor-interacting protein
Short name=GIP
Gene names
Name:C1QTNF1
Synonyms:CTRP1
ORF Names:UNQ310/PRO353
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length281 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Subcellular location

Secreted Potential.

Sequence similarities

Contains 1 C1q domain.

Contains 1 collagen-like domain.

Sequence caution

The sequence AAG44303.1 differs from that shown. Reason: Erroneous initiation.

The sequence CAC20425.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Cellular componentSecreted
   DomainCollagen
Signal
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular componentcollagen

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2525 Potential
Chain26 – 281256Complement C1q tumor necrosis factor-related protein 1
PRO_0000003529

Regions

Domain99 – 14042Collagen-like
Domain141 – 281141C1q

Amino acid modifications

Glycosylation931N-linked (GlcNAc...) Potential

Experimental info

Sequence conflict221L → P in CAC20425. Ref.1
Sequence conflict221L → P in AAG44303. Ref.1
Sequence conflict2411R → Q in CAC20425. Ref.1
Sequence conflict2411R → Q in AAG44303. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q9BXJ1 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: 49E248CB88ACFB7C

FASTA28131,743
        10         20         30         40         50         60 
MGSRGQGLLL AYCLLLAFAS GLVLSRVPHV QGEQQEWEGT EELPSPPDHA ERAEEQHEKY 

        70         80         90        100        110        120 
RPSQDQGLPA SRCLRCCDPG TSMYPATAVP QINITILKGE KGDRGDRGLQ GKYGKTGSAG 

       130        140        150        160        170        180 
ARGHTGPKGQ KGSMGAPGER CKSHYAAFSV GRKKPMHSNH YYQTVIFDTE FVNLYDHFNM 

       190        200        210        220        230        240 
FTGKFYCYVP GLYFFSLNVH TWNQKETYLH IMKNEEEVVI LFAQVGDRSI MQSQSLMLEL 

       250        260        270        280 
REQDQVWVRL YKGERENAIF SEELDTYITF SGYLVKHATE P

« Hide

References

« Hide 'large scale' references
[1]"GIP, a putative GPCR interacting protein."
Innamorati G., Le Gouill C., Whang I., Birnbaumer M.
Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Homo sapiens complement-c1q tumor necrosis factor-related protein."
Sheppard P.O.
Submitted (DEC-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. expand/collapse author list , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.
Genome Res. 13:2265-2270(2003) [PubMed: 12975309] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Skin.
[5]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 83-281.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AJ272138 mRNA. Translation: CAC20425.1. Different initiation.
AF232905 mRNA. Translation: AAG44303.1. Different initiation.
AF329840 mRNA. Translation: AAK17964.1.
AY358424 mRNA. Translation: AAQ88790.1.
BC021553 mRNA. Translation: AAH21553.1.
AK055541 mRNA. Translation: BAB70947.1.
AK075175 mRNA. Translation: BAC11451.1.
IPIIPI00745915.
RefSeqNP_112230.1. NM_030968.2.
NP_940995.1. NM_198593.2.
NP_940996.1. NM_198594.1.
UniGeneHs.201398.

3D structure databases

ProteinModelPortalQ9BXJ1.
SMRQ9BXJ1. Positions 144-278.
ModBaseSearch...

Protein-protein interaction databases

IntActQ9BXJ1. 2 interactions.
STRINGQ9BXJ1.

PTM databases

PhosphoSiteQ9BXJ1.

Polymorphism databases

DMDM20177862.

Proteomic databases

PRIDEQ9BXJ1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000339142; ENSP00000340864; ENSG00000173918.
ENST00000392444; ENSP00000376239; ENSG00000173918.
ENST00000392445; ENSP00000376240; ENSG00000173918.
GeneID114897.
KEGGhsa:114897.
UCSCuc002jwp.1. human.

Organism-specific databases

CTD114897.
GeneCardsGC17P077020.
H-InvDBHIX0014229.
HGNCHGNC:14324. C1QTNF1.
HPACAB025429.
MIM610365. gene.
neXtProtNX_Q9BXJ1.
PharmGKBPA25628.
GenAtlasSearch...

Phylogenomic databases

GeneTreeENSGT00560000076704.
HOVERGENHBG108220.
InParanoidQ9BXJ1.
OrthoDBEOG4XH011.
PhylomeDBQ9BXJ1.

Gene expression databases

ArrayExpressQ9BXJ1.
BgeeQ9BXJ1.
CleanExHS_C1QTNF1.
GenevestigatorQ9BXJ1.
GermOnlineENSG00000173918. Homo sapiens.

Family and domain databases

InterProIPR001073. C1q.
IPR008160. Collagen.
IPR008983. Tumour_necrosis_fac-like.
[Graphical view]
Gene3DG3DSA:2.60.120.40. Tumour_necrosis_fac-like. 1 hit.
PfamPF00386. C1q. 1 hit.
PF01391. Collagen. 1 hit.
[Graphical view]
PRINTSPR00007. COMPLEMNTC1Q.
SMARTSM00110. C1Q. 1 hit.
[Graphical view]
SUPFAMSSF49842. TNF_like. 1 hit.
PROSITEPS50871. C1Q. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio79394.
SOURCESearch...

Entry information

Entry nameC1QT1_HUMAN
AccessionPrimary (citable) accession number: Q9BXJ1
Secondary accession number(s): Q96NF2, Q9GZR4
Entry history
Integrated into UniProtKB/Swiss-Prot: April 16, 2002
Last sequence update: June 1, 2001
Last modified: January 25, 2012
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human chromosome 17

Human chromosome 17: entries, gene names and cross-references to MIM

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents