ID C1QT6_HUMAN Reviewed; 259 AA. AC Q9BXI9; Q5H9G8; Q6ZRM7; DT 16-APR-2002, integrated into UniProtKB/Swiss-Prot. DT 23-SEP-2008, sequence version 3. DT 16-JUN-2009, entry version 74. DE RecName: Full=Complement C1q tumor necrosis factor-related protein 6; DE Flags: Precursor; GN Name=C1QTNF6; Synonyms=CTRP6; ORFNames=UNQ581/PRO1151; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2). RA Piddington C.S., Sheppard P.O.; RT "Homo sapiens complement-c1q tumor necrosis factor-related protein."; RL Submitted (DEC-2000) to the EMBL/GenBank/DDBJ databases. RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANTS VAL-2 RP AND ARG-23. RX MEDLINE=22887296; PubMed=12975309; DOI=10.1101/gr.1293003; RA Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., RA Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., RA Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., RA Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., RA Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., RA Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., RA Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., RA Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., RA Wood W.I., Godowski P.J., Gray A.M.; RT "The secreted protein discovery initiative (SPDI), a large-scale RT effort to identify novel human secreted and transmembrane proteins: a RT bioinformatics assessment."; RL Genome Res. 13:2265-2270(2003). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3). RC TISSUE=Testis; RX PubMed=14702039; DOI=10.1038/ng1285; RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.; RT "Complete sequencing and characterization of 21,243 full-length human RT cDNAs."; RL Nat. Genet. 36:40-45(2004). RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX MEDLINE=20057165; PubMed=10591208; DOI=10.1038/990031; RA Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., RA Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., RA Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P., RA Bird C.P., Blakey S.E., Bridgeman A.M., Buck D., Burgess J., RA Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G., RA Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R., RA Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E., RA Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G., RA Evans K.L., Fey J.M., Fleming K., French L., Garner A.A., RA Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C., RA Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., RA Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A., RA Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M., RA Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T., RA Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J., RA Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T., RA Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T., RA Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L., RA Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M., RA Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L., RA Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L., RA Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N., RA Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., RA Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., RA Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T., RA Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I., RA Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H., RA Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L., RA Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z., RA Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P., RA Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S., RA Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J., RA Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T., RA Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J., RA Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R., RA Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., RA Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., RA Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P., RA Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E., RA O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X., RA Khan A.S., Lane L., Tilahun Y., Wright H.; RT "The DNA sequence of human chromosome 22."; RL Nature 402:489-495(1999). RN [5] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R., RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., RA Venter J.C.; RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases. RN [6] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), AND VARIANT VAL-2. RC TISSUE=Placenta; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA RT project: the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [7] RP PROTEIN SEQUENCE OF 28-42. RX PubMed=15340161; DOI=10.1110/ps.04682504; RA Zhang Z., Henzel W.J.; RT "Signal peptide prediction based on analysis of experimentally RT verified cleavage sites."; RL Protein Sci. 13:2819-2824(2004). CC -!- SUBCELLULAR LOCATION: Secreted (Probable). CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=3; CC Name=1; CC IsoId=Q9BXI9-1; Sequence=Displayed; CC Name=2; CC IsoId=Q9BXI9-2; Sequence=VSP_035473; CC Name=3; CC IsoId=Q9BXI9-3; Sequence=VSP_035472, VSP_035474; CC Note=No experimental confirmation available; CC -!- SIMILARITY: Contains 1 C1q domain. CC -!- SIMILARITY: Contains 1 collagen-like domain. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; AF329842; AAK17966.1; -; mRNA. DR EMBL; AY358374; AAQ88740.1; -; mRNA. DR EMBL; AK128125; BAC87283.1; -; mRNA. DR EMBL; Z82188; CAI19597.1; -; Genomic_DNA. DR EMBL; CH471095; EAW60145.1; -; Genomic_DNA. DR EMBL; BC020551; AAH20551.1; -; mRNA. DR IPI; IPI00419276; -. DR IPI; IPI00443947; -. DR IPI; IPI00909719; -. DR RefSeq; NP_114116.3; -. DR RefSeq; NP_872292.1; -. DR UniGene; Hs.22011; -. DR Ensembl; ENSG00000133466; Homo sapiens. DR GeneID; 114904; -. DR KEGG; hsa:114904; -. DR GeneCards; GC22M035900; -. DR H-InvDB; HIX0016438; -. DR HGNC; HGNC:14343; C1QTNF6. DR HPA; HPA002042; -. DR PharmGKB; PA25633; -. DR HOVERGEN; Q9BXI9; -. DR OMA; Q9BXI9; VRPYINI. DR NextBio; 79420; -. DR ArrayExpress; Q9BXI9; -. DR Bgee; Q9BXI9; -. DR CleanEx; HS_C1QTNF6; -. DR GermOnline; ENSG00000133466; Homo sapiens. DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell. DR InterPro; IPR001073; C1q. DR InterPro; IPR008160; Collagen. DR InterPro; IPR008983; Tumour_necrosis_fac-like. DR Gene3D; G3DSA:2.60.120.40; Tumour_necrosis_fac-like; 1. DR Pfam; PF00386; C1q; 1. DR Pfam; PF01391; Collagen; 1. DR PRINTS; PR00007; COMPLEMNTC1Q. DR ProDom; PD000007; Clg_helix; 1. DR PROSITE; PS50871; C1Q; 1. PE 1: Evidence at protein level; KW Alternative splicing; Collagen; Direct protein sequencing; KW Glycoprotein; Polymorphism; Secreted; Signal. FT SIGNAL 1 27 FT CHAIN 28 259 Complement C1q tumor necrosis factor- FT related protein 6. FT /FTId=PRO_0000003538. FT DOMAIN 78 119 Collagen-like. FT DOMAIN 120 259 C1q. FT CARBOHYD 72 72 N-linked (GlcNAc...) (Potential). FT VAR_SEQ 1 101 Missing (in isoform 3). FT /FTId=VSP_035472. FT VAR_SEQ 1 1 M -> MQWLRVRESPGEATGHRVTM (in isoform 2). FT /FTId=VSP_035473. FT VAR_SEQ 102 128 GPQGSKGDKGEMGSPGAPCQKRFFAFS -> MSVGTSLEQA FT QMSTLTCPLFIPT (in isoform 3). FT /FTId=VSP_035474. FT VARIANT 2 2 G -> V (in dbSNP:rs229527). FT /FTId=VAR_046624. FT VARIANT 23 23 P -> R (in dbSNP:rs229526). FT /FTId=VAR_046625. FT VARIANT 36 36 G -> D (in dbSNP:rs7290488). FT /FTId=VAR_046626. FT VARIANT 119 119 P -> L (in dbSNP:rs17812699). FT /FTId=VAR_046627. FT VARIANT 207 207 R -> H (in dbSNP:rs17812681). FT /FTId=VAR_046628. SQ SEQUENCE 259 AA; 28669 MW; 876DD0F84D217C9A CRC64; MGTAALGPVW AALLLFLLMC EIPMVELTFD RAVASGCQRC CDSEDPLDPA HVSSASSSGR PHALPEIRPY INITILKGDK GDPGPMGLPG YMGREGPQGE PGPQGSKGDK GEMGSPGAPC QKRFFAFSVG RKTALHSGED FQTLLFERVF VNLDGCFDMA TGQFAAPLRG IYFFSLNVHS WNYKETYVHI MHNQKEAVIL YAQPSERSIM QSQSVMLDLA YGDRVWVRLF KRQRENAIYS NDFDTYITFS GHLIKAEDD //