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Protein

Complement C1q tumor necrosis factor-related protein 6

Gene

C1QTNF6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Complement C1q tumor necrosis factor-related protein 6
Gene namesi
Name:C1QTNF6
Synonyms:CTRP6
ORF Names:UNQ581/PRO1151
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

HGNCiHGNC:14343. C1QTNF6.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA25633.

Polymorphism and mutation databases

BioMutaiC1QTNF6.
DMDMi206729927.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 27271 PublicationAdd
BLAST
Chaini28 – 259232Complement C1q tumor necrosis factor-related protein 6PRO_0000003538Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi72 – 721N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ9BXI9.
PaxDbiQ9BXI9.
PRIDEiQ9BXI9.

PTM databases

iPTMnetiQ9BXI9.

Expressioni

Gene expression databases

BgeeiQ9BXI9.
CleanExiHS_C1QTNF6.
ExpressionAtlasiQ9BXI9. baseline and differential.
GenevisibleiQ9BXI9. HS.

Organism-specific databases

HPAiHPA002042.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
SGTAO437653EBI-10301084,EBI-347996

Protein-protein interaction databases

BioGridi125393. 9 interactions.
IntActiQ9BXI9. 9 interactions.
STRINGi9606.ENSP00000338812.

Structurei

3D structure databases

ProteinModelPortaliQ9BXI9.
SMRiQ9BXI9. Positions 94-120, 126-254.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini78 – 11942Collagen-likeAdd
BLAST
Domaini120 – 259140C1qPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 C1q domain.PROSITE-ProRule annotation
Contains 1 collagen-like domain.Curated

Keywords - Domaini

Collagen, Signal

Phylogenomic databases

eggNOGiENOG410IKX5. Eukaryota.
ENOG410XQIM. LUCA.
GeneTreeiENSGT00760000118830.
HOVERGENiHBG108220.
InParanoidiQ9BXI9.
KOiK19470.
OMAiKETYVHV.
OrthoDBiEOG71CFMS.
PhylomeDBiQ9BXI9.
TreeFamiTF329591.

Family and domain databases

Gene3Di2.60.120.40. 1 hit.
InterProiIPR001073. C1q_dom.
IPR008160. Collagen.
IPR008983. Tumour_necrosis_fac-like_dom.
[Graphical view]
PfamiPF00386. C1q. 1 hit.
PF01391. Collagen. 1 hit.
[Graphical view]
PRINTSiPR00007. COMPLEMNTC1Q.
SMARTiSM00110. C1Q. 1 hit.
[Graphical view]
SUPFAMiSSF49842. SSF49842. 1 hit.
PROSITEiPS50871. C1Q. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9BXI9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGTAALGPVW AALLLFLLMC EIPMVELTFD RAVASGCQRC CDSEDPLDPA
60 70 80 90 100
HVSSASSSGR PHALPEIRPY INITILKGDK GDPGPMGLPG YMGREGPQGE
110 120 130 140 150
PGPQGSKGDK GEMGSPGAPC QKRFFAFSVG RKTALHSGED FQTLLFERVF
160 170 180 190 200
VNLDGCFDMA TGQFAAPLRG IYFFSLNVHS WNYKETYVHI MHNQKEAVIL
210 220 230 240 250
YAQPSERSIM QSQSVMLDLA YGDRVWVRLF KRQRENAIYS NDFDTYITFS

GHLIKAEDD
Length:259
Mass (Da):28,669
Last modified:September 23, 2008 - v3
Checksum:i876DD0F84D217C9A
GO
Isoform 2 (identifier: Q9BXI9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MQWLRVRESPGEATGHRVTM

Show »
Length:278
Mass (Da):30,861
Checksum:i27A82CA863F23D47
GO
Isoform 3 (identifier: Q9BXI9-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-101: Missing.
     102-128: GPQGSKGDKGEMGSPGAPCQKRFFAFS → MSVGTSLEQAQMSTLTCPLFIPT

Note: No experimental confirmation available.
Show »
Length:154
Mass (Da):17,720
Checksum:iE2A73F65529ED7A1
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti2 – 21G → V.2 Publications
Corresponds to variant rs229527 [ dbSNP | Ensembl ].
VAR_046624
Natural varianti23 – 231P → R.1 Publication
Corresponds to variant rs229526 [ dbSNP | Ensembl ].
VAR_046625
Natural varianti36 – 361G → D.
Corresponds to variant rs7290488 [ dbSNP | Ensembl ].
VAR_046626
Natural varianti119 – 1191P → L.
Corresponds to variant rs17812699 [ dbSNP | Ensembl ].
VAR_046627
Natural varianti207 – 2071R → H.
Corresponds to variant rs17812681 [ dbSNP | Ensembl ].
VAR_046628

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 101101Missing in isoform 3. 1 PublicationVSP_035472Add
BLAST
Alternative sequencei1 – 11M → MQWLRVRESPGEATGHRVTM in isoform 2. 2 PublicationsVSP_035473
Alternative sequencei102 – 12827GPQGS…FFAFS → MSVGTSLEQAQMSTLTCPLF IPT in isoform 3. 1 PublicationVSP_035474Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF329842 mRNA. Translation: AAK17966.1.
AY358374 mRNA. Translation: AAQ88740.1.
AK128125 mRNA. Translation: BAC87283.1.
Z82188 Genomic DNA. Translation: CAI19597.1.
CH471095 Genomic DNA. Translation: EAW60145.1.
BC020551 mRNA. Translation: AAH20551.1.
CCDSiCCDS13943.1. [Q9BXI9-2]
RefSeqiNP_114116.3. NM_031910.3. [Q9BXI9-2]
NP_872292.1. NM_182486.1. [Q9BXI9-2]
XP_006724188.1. XM_006724125.2. [Q9BXI9-1]
XP_011528159.1. XM_011529857.1. [Q9BXI9-1]
UniGeneiHs.22011.

Genome annotation databases

EnsembliENST00000337843; ENSP00000338812; ENSG00000133466. [Q9BXI9-2]
ENST00000397110; ENSP00000380299; ENSG00000133466. [Q9BXI9-2]
GeneIDi114904.
KEGGihsa:114904.
UCSCiuc003aqx.2. human. [Q9BXI9-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF329842 mRNA. Translation: AAK17966.1.
AY358374 mRNA. Translation: AAQ88740.1.
AK128125 mRNA. Translation: BAC87283.1.
Z82188 Genomic DNA. Translation: CAI19597.1.
CH471095 Genomic DNA. Translation: EAW60145.1.
BC020551 mRNA. Translation: AAH20551.1.
CCDSiCCDS13943.1. [Q9BXI9-2]
RefSeqiNP_114116.3. NM_031910.3. [Q9BXI9-2]
NP_872292.1. NM_182486.1. [Q9BXI9-2]
XP_006724188.1. XM_006724125.2. [Q9BXI9-1]
XP_011528159.1. XM_011529857.1. [Q9BXI9-1]
UniGeneiHs.22011.

3D structure databases

ProteinModelPortaliQ9BXI9.
SMRiQ9BXI9. Positions 94-120, 126-254.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125393. 9 interactions.
IntActiQ9BXI9. 9 interactions.
STRINGi9606.ENSP00000338812.

PTM databases

iPTMnetiQ9BXI9.

Polymorphism and mutation databases

BioMutaiC1QTNF6.
DMDMi206729927.

Proteomic databases

MaxQBiQ9BXI9.
PaxDbiQ9BXI9.
PRIDEiQ9BXI9.

Protocols and materials databases

DNASUi114904.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000337843; ENSP00000338812; ENSG00000133466. [Q9BXI9-2]
ENST00000397110; ENSP00000380299; ENSG00000133466. [Q9BXI9-2]
GeneIDi114904.
KEGGihsa:114904.
UCSCiuc003aqx.2. human. [Q9BXI9-1]

Organism-specific databases

CTDi114904.
GeneCardsiC1QTNF6.
HGNCiHGNC:14343. C1QTNF6.
HPAiHPA002042.
MIMi614910. gene.
neXtProtiNX_Q9BXI9.
PharmGKBiPA25633.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IKX5. Eukaryota.
ENOG410XQIM. LUCA.
GeneTreeiENSGT00760000118830.
HOVERGENiHBG108220.
InParanoidiQ9BXI9.
KOiK19470.
OMAiKETYVHV.
OrthoDBiEOG71CFMS.
PhylomeDBiQ9BXI9.
TreeFamiTF329591.

Miscellaneous databases

ChiTaRSiC1QTNF6. human.
GenomeRNAii114904.
PROiQ9BXI9.
SOURCEiSearch...

Gene expression databases

BgeeiQ9BXI9.
CleanExiHS_C1QTNF6.
ExpressionAtlasiQ9BXI9. baseline and differential.
GenevisibleiQ9BXI9. HS.

Family and domain databases

Gene3Di2.60.120.40. 1 hit.
InterProiIPR001073. C1q_dom.
IPR008160. Collagen.
IPR008983. Tumour_necrosis_fac-like_dom.
[Graphical view]
PfamiPF00386. C1q. 1 hit.
PF01391. Collagen. 1 hit.
[Graphical view]
PRINTSiPR00007. COMPLEMNTC1Q.
SMARTiSM00110. C1Q. 1 hit.
[Graphical view]
SUPFAMiSSF49842. SSF49842. 1 hit.
PROSITEiPS50871. C1Q. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Homo sapiens complement-c1q tumor necrosis factor-related protein."
    Piddington C.S., Sheppard P.O.
    Submitted (DEC-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS VAL-2 AND ARG-23.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Tissue: Testis.
  4. "The DNA sequence of human chromosome 22."
    Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M.
    , Buck D., Burgess J., Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A., Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C., Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L., Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L., Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N., Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R., Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y., Wright H.
    Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT VAL-2.
    Tissue: Placenta.
  7. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."
    Zhang Z., Henzel W.J.
    Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 28-42.

Entry informationi

Entry nameiC1QT6_HUMAN
AccessioniPrimary (citable) accession number: Q9BXI9
Secondary accession number(s): Q5H9G8, Q6ZRM7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 16, 2002
Last sequence update: September 23, 2008
Last modified: June 8, 2016
This is version 139 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.