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Protein

Complement C1q tumor necrosis factor-related protein 6

Gene

C1QTNF6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Complement C1q tumor necrosis factor-related protein 6
Gene namesi
Name:C1QTNF6
Synonyms:CTRP6
ORF Names:UNQ581/PRO1151
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

EuPathDBiHostDB:ENSG00000133466.13.
HGNCiHGNC:14343. C1QTNF6.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi114904.
OpenTargetsiENSG00000133466.
PharmGKBiPA25633.

Polymorphism and mutation databases

BioMutaiC1QTNF6.
DMDMi206729927.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 271 PublicationAdd BLAST27
ChainiPRO_000000353828 – 259Complement C1q tumor necrosis factor-related protein 6Add BLAST232

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi72N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ9BXI9.
PaxDbiQ9BXI9.
PeptideAtlasiQ9BXI9.
PRIDEiQ9BXI9.

PTM databases

iPTMnetiQ9BXI9.
PhosphoSitePlusiQ9BXI9.

Expressioni

Gene expression databases

BgeeiENSG00000133466.
CleanExiHS_C1QTNF6.
ExpressionAtlasiQ9BXI9. baseline and differential.
GenevisibleiQ9BXI9. HS.

Organism-specific databases

HPAiHPA002042.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
SGTAO437653EBI-10301084,EBI-347996

GO - Molecular functioni

Protein-protein interaction databases

BioGridi125393. 9 interactors.
IntActiQ9BXI9. 10 interactors.
STRINGi9606.ENSP00000338812.

Structurei

3D structure databases

ProteinModelPortaliQ9BXI9.
SMRiQ9BXI9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini78 – 119Collagen-likeAdd BLAST42
Domaini120 – 259C1qPROSITE-ProRule annotationAdd BLAST140

Keywords - Domaini

Collagen, Signal

Phylogenomic databases

eggNOGiENOG410IKX5. Eukaryota.
ENOG410XQIM. LUCA.
GeneTreeiENSGT00900000140911.
HOVERGENiHBG108220.
InParanoidiQ9BXI9.
KOiK19470.
OMAiKETYVHV.
OrthoDBiEOG091G0LRA.
PhylomeDBiQ9BXI9.
TreeFamiTF329591.

Family and domain databases

Gene3Di2.60.120.40. 1 hit.
InterProiView protein in InterPro
IPR001073. C1q_dom.
IPR008160. Collagen.
IPR008983. Tumour_necrosis_fac-like_dom.
PfamiView protein in Pfam
PF00386. C1q. 1 hit.
PF01391. Collagen. 1 hit.
PRINTSiPR00007. COMPLEMNTC1Q.
SMARTiView protein in SMART
SM00110. C1Q. 1 hit.
SUPFAMiSSF49842. SSF49842. 1 hit.
PROSITEiView protein in PROSITE
PS50871. C1Q. 1 hit.

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9BXI9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGTAALGPVW AALLLFLLMC EIPMVELTFD RAVASGCQRC CDSEDPLDPA
60 70 80 90 100
HVSSASSSGR PHALPEIRPY INITILKGDK GDPGPMGLPG YMGREGPQGE
110 120 130 140 150
PGPQGSKGDK GEMGSPGAPC QKRFFAFSVG RKTALHSGED FQTLLFERVF
160 170 180 190 200
VNLDGCFDMA TGQFAAPLRG IYFFSLNVHS WNYKETYVHI MHNQKEAVIL
210 220 230 240 250
YAQPSERSIM QSQSVMLDLA YGDRVWVRLF KRQRENAIYS NDFDTYITFS

GHLIKAEDD
Length:259
Mass (Da):28,669
Last modified:September 23, 2008 - v3
Checksum:i876DD0F84D217C9A
GO
Isoform 2 (identifier: Q9BXI9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MQWLRVRESPGEATGHRVTM

Show »
Length:278
Mass (Da):30,861
Checksum:i27A82CA863F23D47
GO
Isoform 3 (identifier: Q9BXI9-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-101: Missing.
     102-128: GPQGSKGDKGEMGSPGAPCQKRFFAFS → MSVGTSLEQAQMSTLTCPLFIPT

Note: No experimental confirmation available.
Show »
Length:154
Mass (Da):17,720
Checksum:iE2A73F65529ED7A1
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0466242G → V2 PublicationsCorresponds to variant dbSNP:rs229527Ensembl.1
Natural variantiVAR_04662523P → R1 PublicationCorresponds to variant dbSNP:rs229526Ensembl.1
Natural variantiVAR_04662636G → D. Corresponds to variant dbSNP:rs7290488Ensembl.1
Natural variantiVAR_046627119P → L. Corresponds to variant dbSNP:rs17812699Ensembl.1
Natural variantiVAR_046628207R → H. Corresponds to variant dbSNP:rs17812681Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0354721 – 101Missing in isoform 3. 1 PublicationAdd BLAST101
Alternative sequenceiVSP_0354731M → MQWLRVRESPGEATGHRVTM in isoform 2. 2 Publications1
Alternative sequenceiVSP_035474102 – 128GPQGS…FFAFS → MSVGTSLEQAQMSTLTCPLF IPT in isoform 3. 1 PublicationAdd BLAST27

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF329842 mRNA. Translation: AAK17966.1.
AY358374 mRNA. Translation: AAQ88740.1.
AK128125 mRNA. Translation: BAC87283.1.
Z82188 Genomic DNA. Translation: CAI19597.1.
CH471095 Genomic DNA. Translation: EAW60145.1.
BC020551 mRNA. Translation: AAH20551.1.
CCDSiCCDS13943.1. [Q9BXI9-2]
RefSeqiNP_114116.3. NM_031910.3. [Q9BXI9-2]
NP_872292.1. NM_182486.1. [Q9BXI9-2]
XP_011528159.1. XM_011529857.1. [Q9BXI9-1]
XP_016884059.1. XM_017028570.1. [Q9BXI9-1]
XP_016884060.1. XM_017028571.1. [Q9BXI9-1]
XP_016884061.1. XM_017028572.1. [Q9BXI9-1]
XP_016884062.1. XM_017028573.1. [Q9BXI9-1]
XP_016884063.1. XM_017028574.1. [Q9BXI9-1]
UniGeneiHs.22011.

Genome annotation databases

EnsembliENST00000337843; ENSP00000338812; ENSG00000133466. [Q9BXI9-2]
ENST00000397110; ENSP00000380299; ENSG00000133466. [Q9BXI9-2]
GeneIDi114904.
KEGGihsa:114904.
UCSCiuc003aqx.2. human. [Q9BXI9-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiC1QT6_HUMAN
AccessioniPrimary (citable) accession number: Q9BXI9
Secondary accession number(s): Q5H9G8, Q6ZRM7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 16, 2002
Last sequence update: September 23, 2008
Last modified: October 25, 2017
This is version 148 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot