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Q9BXI3 (5NT1A_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 92. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytosolic 5'-nucleotidase 1A

Short name=cN1A
EC=3.1.3.5
Alternative name(s):
Cytosolic 5'-nucleotidase IA
Short name=cN-I
Short name=cN-IA
Gene names
Name:NT5C1A
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length368 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Dephosphorylates the 5' and 2'(3')-phosphates of deoxyribonucleotides and has a broad substrate specificity. Helps to regulate adenosine levels in heart during ischemia and hypoxia. Ref.1

Catalytic activity

A 5'-ribonucleotide + H2O = a ribonucleoside + phosphate.

Cofactor

Magnesium.

Enzyme regulation

Activated by ADP.

Subcellular location

Cytoplasm.

Tissue specificity

Highly expressed in skeletal muscle. Detected at intermediate levels in heart, brain, kidney and pancreas. Ref.1

Sequence similarities

Belongs to the 5'-nucleotidase type 3 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 368368Cytosolic 5'-nucleotidase 1A
PRO_0000144795

Sites

Active site2111Nucleophile By similarity

Experimental info

Sequence conflict9 – 113Missing in AAK30000. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q9BXI3 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: 7FB3CCEED50BA50D

FASTA36841,021
        10         20         30         40         50         60 
MEPGQPREPQ EPREPGPGAE TAAAPVWEEA KIFYDNLAPK KKPKSPKPQN AVTIAVSSRA 

        70         80         90        100        110        120 
LFRMDEEQQI YTEQGVEEYV RYQLEHENEP FSPGPAFPFV KALEAVNRRL RELYPDSEDV 

       130        140        150        160        170        180 
FDIVLMTNNH AQVGVRLINS INHYDLFIER FCMTGGNSPI CYLKAYHTNL YLSADAEKVR 

       190        200        210        220        230        240 
EAIDEGIAAA TIFSPSRDVV VSQSQLRVAF DGDAVLFSDE SERIVKAHGL DRFFEHEKAH 

       250        260        270        280        290        300 
ENKPLAQGPL KGFLEALGRL QKKFYSKGLR LECPIRTYLV TARSAASSGA RALKTLRSWG 

       310        320        330        340        350        360 
LETDEALFLA GAPKGPLLEK IRPHIFFDDQ MFHVAGAQEM GTVAAHVPYG VAQTPRRTAP 


AKQAPSAQ 

« Hide

References

« Hide 'large scale' references
[1]"Human cytosolic 5'-nucleotidase I: characterization and role in nucleoside analog resistance."
Hunsucker S.A., Spychala J., Mitchell B.S.
J. Biol. Chem. 276:10498-10504(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
Tissue: Heart.
[2]"5'-nucleotidase I from human heart."
Lowenstein J.M., Huang J., Steiner A.
Submitted (MAR-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Heart.
[3]"The DNA sequence and biological annotation of human chromosome 1."
Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. expand/collapse author list , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF331801 mRNA. Translation: AAK01294.1.
AY028778 mRNA. Translation: AAK30000.1.
AL035404 Genomic DNA. Translation: CAI19573.1.
BC103879 mRNA. Translation: AAI03880.1.
BC103880 mRNA. Translation: AAI03881.1.
RefSeqNP_115915.1. NM_032526.1.
UniGeneHs.307006.

3D structure databases

ProteinModelPortalQ9BXI3.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000235628.

PTM databases

PhosphoSiteQ9BXI3.

Polymorphism databases

DMDM47116736.

Proteomic databases

PaxDbQ9BXI3.
PRIDEQ9BXI3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000235628; ENSP00000235628; ENSG00000116981.
GeneID84618.
KEGGhsa:84618.
UCSCuc001cdq.1. human.

Organism-specific databases

CTD84618.
GeneCardsGC01M040154.
HGNCHGNC:17819. NT5C1A.
HPAHPA050283.
HPA054158.
MIM610525. gene.
neXtProtNX_Q9BXI3.
PharmGKBPA31799.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG46880.
HOGENOMHOG000243802.
HOVERGENHBG101325.
InParanoidQ9BXI3.
KOK01081.
OMAINHYDLF.
OrthoDBEOG79KPF1.
PhylomeDBQ9BXI3.
TreeFamTF329831.

Enzyme and pathway databases

BioCycMetaCyc:HS04074-MONOMER.
BRENDA3.1.3.5. 2681.
ReactomeREACT_111217. Metabolism.
SABIO-RKQ9BXI3.

Gene expression databases

BgeeQ9BXI3.
CleanExHS_NT5C1A.
GenevestigatorQ9BXI3.

Family and domain databases

InterProIPR010394. 5-nucleotidase.
[Graphical view]
PfamPF06189. 5-nucleotidase. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi84618.
NextBio74492.
PROQ9BXI3.
SOURCESearch...

Entry information

Entry name5NT1A_HUMAN
AccessionPrimary (citable) accession number: Q9BXI3
Secondary accession number(s): Q3SYB9, Q5TG98, Q9BWT8
Entry history
Integrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: June 1, 2001
Last modified: April 16, 2014
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 1

Human chromosome 1: entries, gene names and cross-references to MIM