Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q9BXI3

- 5NT1A_HUMAN

UniProt

Q9BXI3 - 5NT1A_HUMAN

Protein

Cytosolic 5'-nucleotidase 1A

Gene

NT5C1A

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 96 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Dephosphorylates the 5' and 2'(3')-phosphates of deoxyribonucleotides and has a broad substrate specificity. Helps to regulate adenosine levels in heart during ischemia and hypoxia.1 Publication

    Catalytic activityi

    A 5'-ribonucleotide + H2O = a ribonucleoside + phosphate.

    Cofactori

    Magnesium.

    Enzyme regulationi

    Activated by ADP.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei211 – 2111NucleophileBy similarity

    GO - Molecular functioni

    1. 5'-nucleotidase activity Source: UniProtKB
    2. magnesium ion binding Source: InterPro
    3. nucleotide binding Source: UniProtKB-KW

    GO - Biological processi

    1. adenosine metabolic process Source: Ensembl
    2. dephosphorylation Source: GOC
    3. nucleobase-containing small molecule metabolic process Source: Reactome
    4. nucleoside metabolic process Source: UniProtKB
    5. purine nucleobase metabolic process Source: Reactome
    6. purine nucleoside monophosphate catabolic process Source: Ensembl
    7. purine nucleotide catabolic process Source: Reactome
    8. pyrimidine nucleobase metabolic process Source: Reactome
    9. pyrimidine nucleoside catabolic process Source: Reactome
    10. small molecule metabolic process Source: Reactome

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Nucleotide metabolism

    Keywords - Ligandi

    Magnesium, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciMetaCyc:HS04074-MONOMER.
    BRENDAi3.1.3.5. 2681.
    ReactomeiREACT_1023. Pyrimidine catabolism.
    REACT_2086. Purine catabolism.
    SABIO-RKQ9BXI3.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytosolic 5'-nucleotidase 1A (EC:3.1.3.5)
    Short name:
    cN1A
    Alternative name(s):
    Cytosolic 5'-nucleotidase IA
    Short name:
    cN-I
    Short name:
    cN-IA
    Gene namesi
    Name:NT5C1A
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:17819. NT5C1A.

    Subcellular locationi

    GO - Cellular componenti

    1. cytosol Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA31799.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 368368Cytosolic 5'-nucleotidase 1APRO_0000144795Add
    BLAST

    Proteomic databases

    PaxDbiQ9BXI3.
    PRIDEiQ9BXI3.

    PTM databases

    PhosphoSiteiQ9BXI3.

    Expressioni

    Tissue specificityi

    Highly expressed in skeletal muscle. Detected at intermediate levels in heart, brain, kidney and pancreas.1 Publication

    Gene expression databases

    BgeeiQ9BXI3.
    CleanExiHS_NT5C1A.
    GenevestigatoriQ9BXI3.

    Organism-specific databases

    HPAiHPA050283.
    HPA054158.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000235628.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9BXI3.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the 5'-nucleotidase type 3 family.Curated

    Phylogenomic databases

    eggNOGiNOG46880.
    HOGENOMiHOG000243802.
    HOVERGENiHBG101325.
    InParanoidiQ9BXI3.
    KOiK01081.
    OMAiKSPKPQN.
    OrthoDBiEOG79KPF1.
    PhylomeDBiQ9BXI3.
    TreeFamiTF329831.

    Family and domain databases

    InterProiIPR010394. 5-nucleotidase.
    [Graphical view]
    PfamiPF06189. 5-nucleotidase. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9BXI3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEPGQPREPQ EPREPGPGAE TAAAPVWEEA KIFYDNLAPK KKPKSPKPQN    50
    AVTIAVSSRA LFRMDEEQQI YTEQGVEEYV RYQLEHENEP FSPGPAFPFV 100
    KALEAVNRRL RELYPDSEDV FDIVLMTNNH AQVGVRLINS INHYDLFIER 150
    FCMTGGNSPI CYLKAYHTNL YLSADAEKVR EAIDEGIAAA TIFSPSRDVV 200
    VSQSQLRVAF DGDAVLFSDE SERIVKAHGL DRFFEHEKAH ENKPLAQGPL 250
    KGFLEALGRL QKKFYSKGLR LECPIRTYLV TARSAASSGA RALKTLRSWG 300
    LETDEALFLA GAPKGPLLEK IRPHIFFDDQ MFHVAGAQEM GTVAAHVPYG 350
    VAQTPRRTAP AKQAPSAQ 368
    Length:368
    Mass (Da):41,021
    Last modified:June 1, 2001 - v1
    Checksum:i7FB3CCEED50BA50D
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti9 – 113Missing in AAK30000. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF331801 mRNA. Translation: AAK01294.1.
    AY028778 mRNA. Translation: AAK30000.1.
    AL035404 Genomic DNA. Translation: CAI19573.1.
    BC103879 mRNA. Translation: AAI03880.1.
    BC103880 mRNA. Translation: AAI03881.1.
    CCDSiCCDS440.1.
    RefSeqiNP_115915.1. NM_032526.1.
    UniGeneiHs.307006.

    Genome annotation databases

    EnsembliENST00000235628; ENSP00000235628; ENSG00000116981.
    GeneIDi84618.
    KEGGihsa:84618.
    UCSCiuc001cdq.1. human.

    Polymorphism databases

    DMDMi47116736.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF331801 mRNA. Translation: AAK01294.1 .
    AY028778 mRNA. Translation: AAK30000.1 .
    AL035404 Genomic DNA. Translation: CAI19573.1 .
    BC103879 mRNA. Translation: AAI03880.1 .
    BC103880 mRNA. Translation: AAI03881.1 .
    CCDSi CCDS440.1.
    RefSeqi NP_115915.1. NM_032526.1.
    UniGenei Hs.307006.

    3D structure databases

    ProteinModelPortali Q9BXI3.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000235628.

    PTM databases

    PhosphoSitei Q9BXI3.

    Polymorphism databases

    DMDMi 47116736.

    Proteomic databases

    PaxDbi Q9BXI3.
    PRIDEi Q9BXI3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000235628 ; ENSP00000235628 ; ENSG00000116981 .
    GeneIDi 84618.
    KEGGi hsa:84618.
    UCSCi uc001cdq.1. human.

    Organism-specific databases

    CTDi 84618.
    GeneCardsi GC01M040154.
    HGNCi HGNC:17819. NT5C1A.
    HPAi HPA050283.
    HPA054158.
    MIMi 610525. gene.
    neXtProti NX_Q9BXI3.
    PharmGKBi PA31799.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG46880.
    HOGENOMi HOG000243802.
    HOVERGENi HBG101325.
    InParanoidi Q9BXI3.
    KOi K01081.
    OMAi KSPKPQN.
    OrthoDBi EOG79KPF1.
    PhylomeDBi Q9BXI3.
    TreeFami TF329831.

    Enzyme and pathway databases

    BioCyci MetaCyc:HS04074-MONOMER.
    BRENDAi 3.1.3.5. 2681.
    Reactomei REACT_1023. Pyrimidine catabolism.
    REACT_2086. Purine catabolism.
    SABIO-RK Q9BXI3.

    Miscellaneous databases

    GenomeRNAii 84618.
    NextBioi 74492.
    PROi Q9BXI3.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9BXI3.
    CleanExi HS_NT5C1A.
    Genevestigatori Q9BXI3.

    Family and domain databases

    InterProi IPR010394. 5-nucleotidase.
    [Graphical view ]
    Pfami PF06189. 5-nucleotidase. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Human cytosolic 5'-nucleotidase I: characterization and role in nucleoside analog resistance."
      Hunsucker S.A., Spychala J., Mitchell B.S.
      J. Biol. Chem. 276:10498-10504(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
      Tissue: Heart.
    2. "5'-nucleotidase I from human heart."
      Lowenstein J.M., Huang J., Steiner A.
      Submitted (MAR-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Heart.
    3. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

    Entry informationi

    Entry namei5NT1A_HUMAN
    AccessioniPrimary (citable) accession number: Q9BXI3
    Secondary accession number(s): Q3SYB9, Q5TG98, Q9BWT8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 10, 2004
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 96 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3