Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Mitochondrial ornithine transporter 2

Gene

SLC25A2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Ornithine transport across inner mitochondrial membrane, from the cytoplasm to the matrix.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

ReactomeiR-HSA-70635. Urea cycle.

Protein family/group databases

TCDBi2.A.29.19.1. the mitochondrial carrier (mc) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial ornithine transporter 2
Alternative name(s):
Solute carrier family 25 member 2
Gene namesi
Name:SLC25A2
Synonyms:ORNT2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:22921. SLC25A2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei5 – 2521Helical; Name=1Sequence analysisAdd
BLAST
Transmembranei68 – 8821Helical; Name=2Sequence analysisAdd
BLAST
Transmembranei110 – 13021Helical; Name=3Sequence analysisAdd
BLAST
Transmembranei168 – 18821Helical; Name=4Sequence analysisAdd
BLAST
Transmembranei210 – 23021Helical; Name=5Sequence analysisAdd
BLAST
Transmembranei237 – 25721Helical; Name=6Sequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134910073.

Chemistry

DrugBankiDB00129. L-Ornithine.

Polymorphism and mutation databases

BioMutaiSLC25A2.
DMDMi209572728.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 301301Mitochondrial ornithine transporter 2PRO_0000090652Add
BLAST

Proteomic databases

PaxDbiQ9BXI2.
PeptideAtlasiQ9BXI2.
PRIDEiQ9BXI2.

PTM databases

iPTMnetiQ9BXI2.
PhosphoSiteiQ9BXI2.

Expressioni

Tissue specificityi

Expressed in liver, kidney, pancreas and cultured fibroblasts.

Gene expression databases

BgeeiENSG00000120329.
CleanExiHS_SLC25A2.
GenevisibleiQ9BXI2. HS.

Organism-specific databases

HPAiHPA042146.

Interactioni

Protein-protein interaction databases

BioGridi123796. 2 interactions.
STRINGi9606.ENSP00000239451.

Structurei

3D structure databases

ProteinModelPortaliQ9BXI2.
SMRiQ9BXI2. Positions 17-300.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati7 – 9185Solcar 1Add
BLAST
Repeati104 – 19794Solcar 2Add
BLAST
Repeati207 – 29387Solcar 3Add
BLAST

Sequence similaritiesi

Contains 3 Solcar repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0763. Eukaryota.
ENOG410XNVH. LUCA.
GeneTreeiENSGT00730000110966.
HOGENOMiHOG000168307.
HOVERGENiHBG062630.
InParanoidiQ9BXI2.
KOiK15101.
OMAiEYSRRMM.
OrthoDBiEOG091G0HVE.
PhylomeDBiQ9BXI2.
TreeFamiTF314880.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9BXI2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKSGPGIQAA IDLTAGAAGG TACVLTGQPF DTIKVKMQTF PDLYKGLTDC
60 70 80 90 100
FLKTYAQVGL RGFYKGTGPA LMAYVAENSV LFMCYGFCQQ FVRKVAGMDK
110 120 130 140 150
QAKLSDLQTA AAGSFASAFA ALALCPTELV KCRLQTMYEM EMSGKIAKSH
160 170 180 190 200
NTIWSVVKGI LKKDGPLGFY HGLSSTLLQE VPGYFFFFGG YELSRSFFAS
210 220 230 240 250
GRSKDELGPV HLMLSGGVAG ICLWLVVFPV DCIKSRIQVL SMYGKQAGFI
260 270 280 290 300
GTLLSVVRNE GIVALYSGLK ATMIRAIPAN GALFVAYEYS RKMMMKQLEA

Y
Length:301
Mass (Da):32,580
Last modified:October 14, 2008 - v3
Checksum:iF22760BADE31DE21
GO

Polymorphismi

Variant Cys-159 has a reduced ornithine transport activity, while variant Gly-181 has an increased activity.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti159 – 1591G → C.2 Publications
Corresponds to variant rs10075302 [ dbSNP | Ensembl ].
VAR_017248
Natural varianti181 – 1811V → G.1 Publication
Corresponds to variant rs3749779 [ dbSNP | Ensembl ].
VAR_017249
Natural varianti226 – 2261V → I.
Corresponds to variant rs3749780 [ dbSNP | Ensembl ].
VAR_017250

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF332005 mRNA. Translation: AAK26320.1.
AF378119 mRNA. Translation: AAM94902.1.
AY208943 mRNA. Translation: AAO31753.1.
CH471062 Genomic DNA. Translation: EAW61967.1.
BC069458 mRNA. Translation: AAH69458.1.
BC100935 mRNA. Translation: AAI00936.1.
BC100936 mRNA. Translation: AAI00937.1.
BC100937 mRNA. Translation: AAI00938.1.
CCDSiCCDS4258.1.
RefSeqiNP_114153.1. NM_031947.3.
UniGeneiHs.97647.

Genome annotation databases

EnsembliENST00000239451; ENSP00000239451; ENSG00000120329.
GeneIDi83884.
KEGGihsa:83884.
UCSCiuc003ljf.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF332005 mRNA. Translation: AAK26320.1.
AF378119 mRNA. Translation: AAM94902.1.
AY208943 mRNA. Translation: AAO31753.1.
CH471062 Genomic DNA. Translation: EAW61967.1.
BC069458 mRNA. Translation: AAH69458.1.
BC100935 mRNA. Translation: AAI00936.1.
BC100936 mRNA. Translation: AAI00937.1.
BC100937 mRNA. Translation: AAI00938.1.
CCDSiCCDS4258.1.
RefSeqiNP_114153.1. NM_031947.3.
UniGeneiHs.97647.

3D structure databases

ProteinModelPortaliQ9BXI2.
SMRiQ9BXI2. Positions 17-300.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123796. 2 interactions.
STRINGi9606.ENSP00000239451.

Chemistry

DrugBankiDB00129. L-Ornithine.

Protein family/group databases

TCDBi2.A.29.19.1. the mitochondrial carrier (mc) family.

PTM databases

iPTMnetiQ9BXI2.
PhosphoSiteiQ9BXI2.

Polymorphism and mutation databases

BioMutaiSLC25A2.
DMDMi209572728.

Proteomic databases

PaxDbiQ9BXI2.
PeptideAtlasiQ9BXI2.
PRIDEiQ9BXI2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000239451; ENSP00000239451; ENSG00000120329.
GeneIDi83884.
KEGGihsa:83884.
UCSCiuc003ljf.3. human.

Organism-specific databases

CTDi83884.
GeneCardsiSLC25A2.
HGNCiHGNC:22921. SLC25A2.
HPAiHPA042146.
MIMi608157. gene.
neXtProtiNX_Q9BXI2.
PharmGKBiPA134910073.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0763. Eukaryota.
ENOG410XNVH. LUCA.
GeneTreeiENSGT00730000110966.
HOGENOMiHOG000168307.
HOVERGENiHBG062630.
InParanoidiQ9BXI2.
KOiK15101.
OMAiEYSRRMM.
OrthoDBiEOG091G0HVE.
PhylomeDBiQ9BXI2.
TreeFamiTF314880.

Enzyme and pathway databases

ReactomeiR-HSA-70635. Urea cycle.

Miscellaneous databases

GenomeRNAii83884.
PROiQ9BXI2.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000120329.
CleanExiHS_SLC25A2.
GenevisibleiQ9BXI2. HS.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiORNT2_HUMAN
AccessioniPrimary (citable) accession number: Q9BXI2
Secondary accession number(s): Q496C1, Q6XUI0, Q8NFZ2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 11, 2002
Last sequence update: October 14, 2008
Last modified: September 7, 2016
This is version 127 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.