Reviewed, UniProtKB/Swiss-Prot Q9BXH5 (TTY6_HUMAN)

Names and origin

Protein names

Recommended name:
    Putative transcript Y 6 protein
Alternative name(s):
    Testis-specific Y-linked 6

Gene names

Name:	TTTY6
Synonyms:	TTY6
AND
Name:	TTTY6B

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	95 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Uncertain.

General annotation (Comments)

Caution

Could be the product of a pseudogene. According to Ref.3, may be a non-coding mRNA.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing
Technical term	Complete proteome
Gene Ontology (GO)
None. [Check GOA]

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9BXH5-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9BXH5-2)

The sequence of this isoform differs from the canonical sequence as follows:
     65-65: S → SVLQGLLVKWRNHDKGKSKVEQYSHSSKWTPTGA

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 95	95	Putative transcript Y 6 protein		PRO_0000065687
Natural variations
	Alternative sequence	65	1	S → SVLQGLLVKWRNHDKGKSKV EQYSHSSKWTPTGA in isoform 2.		VSP_026590
Experimental info
	Sequence conflict	69	1	V → A in AAT09001. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified June 1, 2001. Version 1. Checksum: 886C243D08A0D8FC	FASTA	95	10,465
	10 20 30 40 50 60 MHLHRGLLLS QASGNCGIHA VPVICSHWRR RCLDCDGVSE NCSSDFIPER GCVQELSPRG 70 80 90 TGMLSGECVG PHPPLTSLYP HLYLMLWLLK VSVPK
	Isoform 2. Checksum: A3424367913B189B	FASTA	128	14,213
	10 20 30 40 50 60 MHLHRGLLLS QASGNCGIHA VPVICSHWRR RCLDCDGVSE NCSSDFIPER GCVQELSPRG 70 80 90 100 110 120 TGMLSVLQGL LVKWRNHDKG KSKVEQYSHS SKWTPTGAGE CVGPHPPLTS LYPHLYLMLW LLKVSVPK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	Zhou G., Ke R., Zhong G., Li H., Shen C., Lin L., Yang S. Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
[2]	"The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes." Skaletsky H., Kuroda-Kawaguchi T., Minx P.J., Cordum H.S., Hillier L.W., Brown L.G., Repping S., Pyntikova T., Ali J., Bieri T., Chinwalla A., Delehaunty A., Delehaunty K., Du H., Fewell G., Fulton L., Fulton R., Graves T.A. , Hou S.-F., Latrielle P., Leonard S., Mardis E., Maupin R., McPherson J., Miner T., Nash W., Nguyen C., Ozersky P., Pepin K., Rock S., Rohlfing T., Scott K., Schultz B., Strong C., Tin-Wollam A., Yang S.-P., Waterston R.H., Wilson R.K., Rozen S., Page D.C. Nature 423:825-837(2003) [PubMed: 12815422] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA / MRNA]. Tissue: Testis.
[3]	"Discrimination of non-protein-coding transcripts from protein-coding mRNA." Frith M.C., Bailey T.L., Kasukawa T., Mignone F., Kummerfeld S.K., Madera M., Sunkara S., Furuno M., Bult C.J., Quackenbush J., Kai C., Kawai J., Carninci P., Hayashizaki Y., Pesole G., Mattick J.S. RNA Biol. 3:40-48(2006) [PubMed: 17114936] [Abstract] Cited for: IDENTIFICATION.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AY597808 mRNA. Translation: AAT09001.1. AF332237 mRNA. Translation: AAK13487.1. AC023342 Genomic DNA. No translation available.
IPI	IPI00000304. IPI00472295.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q9BXH5.
Proteomic databases
PRIDE	Q9BXH5.
Organism-specific databases
GeneCards	GC0YM022995. GC0YP022630.
H-InvDB	HIX0056676. HIX0056696.
HGNC	HGNC:16483. TTTY6. HGNC:31887. TTTY6B.
MIM	400039. gene.
PharmGKB	PA38151.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	Q9BXH5.
Gene expression databases
CleanEx	HS_TTTY6. HS_TTTY6B.
Genevestigator	Q9BXH5.
GermOnline	ENSG00000131538. Homo sapiens. ENSG00000131548. Homo sapiens.
Family and domain databases
ProtoNet	Search...
Other Resources
SOURCE	Search...

Entry information

Entry name

TTY6_HUMAN

Accession

Primary (citable) accession number: Q9BXH5
Secondary accession number(s): Q6PL48

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 30, 2003
Last sequence update:	June 1, 2001
Last modified:	November 24, 2009
This is version 39 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.