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Protein

Tektin-3

Gene

TEKT3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Structural component of ciliary and flagellar microtubules. Forms filamentous polymers in the walls of ciliary and flagellar microtubules. Required for progressive sperm mobility (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000125409-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Tektin-3
Gene namesi
Name:TEKT3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:14293. TEKT3.

Subcellular locationi

GO - Cellular componenti

  • acrosomal membrane Source: UniProtKB
  • extracellular exosome Source: UniProtKB
  • microtubule Source: UniProtKB-KW
  • nucleus Source: UniProtKB
  • sperm flagellum Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Cilium, Cytoplasm, Cytoskeleton, Microtubule

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000125409.
PharmGKBiPA37865.

Polymorphism and mutation databases

BioMutaiTEKT3.
DMDMi25009463.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001845681 – 490Tektin-3Add BLAST490

Proteomic databases

PaxDbiQ9BXF9.
PeptideAtlasiQ9BXF9.
PRIDEiQ9BXF9.

PTM databases

iPTMnetiQ9BXF9.
PhosphoSitePlusiQ9BXF9.

Expressioni

Gene expression databases

BgeeiENSG00000125409.
CleanExiHS_TEKT3.
ExpressionAtlasiQ9BXF9. baseline and differential.
GenevisibleiQ9BXF9. HS.

Organism-specific databases

HPAiHPA044354.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
CALCOCO2Q131373EBI-8644516,EBI-739580
GORASP2Q9H8Y84EBI-8644516,EBI-739467
TRAF2Q129335EBI-8644516,EBI-355744

Protein-protein interaction databases

BioGridi122203. 9 interactors.
IntActiQ9BXF9. 10 interactors.
STRINGi9606.ENSP00000343995.

Structurei

3D structure databases

ProteinModelPortaliQ9BXF9.
SMRiQ9BXF9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili415 – 461Sequence analysisAdd BLAST47

Sequence similaritiesi

Belongs to the tektin family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG2685. Eukaryota.
ENOG410XSCN. LUCA.
GeneTreeiENSGT00390000016344.
HOGENOMiHOG000246943.
HOVERGENiHBG056503.
InParanoidiQ9BXF9.
KOiK18630.
OMAiIQTHLAK.
OrthoDBiEOG091G0AJL.
PhylomeDBiQ9BXF9.
TreeFamiTF320754.

Family and domain databases

InterProiIPR000435. Tektin.
[Graphical view]
PANTHERiPTHR19960. PTHR19960. 1 hit.
PRINTSiPR00511. TEKTIN.

Sequencei

Sequence statusi: Complete.

Q9BXF9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MERVGCTLTT TYAHPRPTPT NFLPAISTMA SSYRDRFPHS NLTHSLSLPW
60 70 80 90 100
RPSTYYKVAS NSPSVAPYCT RSQRVSENTM LPFVSNRTTF FTRYTPDDWY
110 120 130 140 150
RSNLTNYQES NTSRHNSEKL RVDTSRLIQD KYQQTRKTQA DTTQNLGERV
160 170 180 190 200
NDIGFWKSEI IHELDEMIGE TNALTDVKKR LERALMETEA PLQVARECLF
210 220 230 240 250
HREKRMGIDL VHDEVEAQLL TEVDTILCCQ ERMKLHLDKA IAQLAANRAS
260 270 280 290 300
QHELEKDLSD KQTAYRIDDK CHHLRNTSDG VGYFRGVERV DATVSVPESW
310 320 330 340 350
AKFTDDNILR SQSERAASAK LRDDIENLLV VTANEMWNQF NKVNLSFTNR
360 370 380 390 400
IAETADAKNK IQTHLAKTLQ EIFQTEMTIE SIKKAIKDKT AFLKVAQTRL
410 420 430 440 450
DERTRRPNIE LCRDMAQLRL VNEVHEVDDT IQTLQQRLRD AEDTLQSLVH
460 470 480 490
IKATLEYDLA VKANSLYIDQ EKCMSMRKSY PNTLRLVGFC
Length:490
Mass (Da):56,636
Last modified:June 1, 2001 - v1
Checksum:iF385314A08651C69
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti268D → N in AAH31688 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0537213R → H.Corresponds to variant rs7226363dbSNPEnsembl.1
Natural variantiVAR_024658282G → A.2 PublicationsCorresponds to variant rs230898dbSNPEnsembl.1
Natural variantiVAR_024659296V → A.Corresponds to variant rs6502446dbSNPEnsembl.1
Natural variantiVAR_034550410E → D.Corresponds to variant rs35855709dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF334676 mRNA. Translation: AAK15340.1.
AK057390 mRNA. Translation: BAB71464.1.
AK314327 mRNA. Translation: BAG36974.1.
CH471108 Genomic DNA. Translation: EAW89942.1.
CH471108 Genomic DNA. Translation: EAW89943.1.
CH471108 Genomic DNA. Translation: EAW89944.1.
BC031688 mRNA. Translation: AAH31688.1.
CCDSiCCDS11169.1.
RefSeqiNP_114104.1. NM_031898.2.
XP_011522290.1. XM_011523988.2.
XP_011522291.1. XM_011523989.1.
XP_016880443.1. XM_017024954.1.
UniGeneiHs.414648.

Genome annotation databases

EnsembliENST00000338696; ENSP00000343995; ENSG00000125409.
ENST00000395930; ENSP00000379263; ENSG00000125409.
GeneIDi64518.
KEGGihsa:64518.
UCSCiuc002gon.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF334676 mRNA. Translation: AAK15340.1.
AK057390 mRNA. Translation: BAB71464.1.
AK314327 mRNA. Translation: BAG36974.1.
CH471108 Genomic DNA. Translation: EAW89942.1.
CH471108 Genomic DNA. Translation: EAW89943.1.
CH471108 Genomic DNA. Translation: EAW89944.1.
BC031688 mRNA. Translation: AAH31688.1.
CCDSiCCDS11169.1.
RefSeqiNP_114104.1. NM_031898.2.
XP_011522290.1. XM_011523988.2.
XP_011522291.1. XM_011523989.1.
XP_016880443.1. XM_017024954.1.
UniGeneiHs.414648.

3D structure databases

ProteinModelPortaliQ9BXF9.
SMRiQ9BXF9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122203. 9 interactors.
IntActiQ9BXF9. 10 interactors.
STRINGi9606.ENSP00000343995.

PTM databases

iPTMnetiQ9BXF9.
PhosphoSitePlusiQ9BXF9.

Polymorphism and mutation databases

BioMutaiTEKT3.
DMDMi25009463.

Proteomic databases

PaxDbiQ9BXF9.
PeptideAtlasiQ9BXF9.
PRIDEiQ9BXF9.

Protocols and materials databases

DNASUi64518.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000338696; ENSP00000343995; ENSG00000125409.
ENST00000395930; ENSP00000379263; ENSG00000125409.
GeneIDi64518.
KEGGihsa:64518.
UCSCiuc002gon.4. human.

Organism-specific databases

CTDi64518.
GeneCardsiTEKT3.
HGNCiHGNC:14293. TEKT3.
HPAiHPA044354.
MIMi612683. gene.
neXtProtiNX_Q9BXF9.
OpenTargetsiENSG00000125409.
PharmGKBiPA37865.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2685. Eukaryota.
ENOG410XSCN. LUCA.
GeneTreeiENSGT00390000016344.
HOGENOMiHOG000246943.
HOVERGENiHBG056503.
InParanoidiQ9BXF9.
KOiK18630.
OMAiIQTHLAK.
OrthoDBiEOG091G0AJL.
PhylomeDBiQ9BXF9.
TreeFamiTF320754.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000125409-MONOMER.

Miscellaneous databases

GenomeRNAii64518.
PROiQ9BXF9.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000125409.
CleanExiHS_TEKT3.
ExpressionAtlasiQ9BXF9. baseline and differential.
GenevisibleiQ9BXF9. HS.

Family and domain databases

InterProiIPR000435. Tektin.
[Graphical view]
PANTHERiPTHR19960. PTHR19960. 1 hit.
PRINTSiPR00511. TEKTIN.
ProtoNetiSearch...

Entry informationi

Entry nameiTEKT3_HUMAN
AccessioniPrimary (citable) accession number: Q9BXF9
Secondary accession number(s): B2RAS7
, D3DTT0, Q8N5R5, Q96M48
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 8, 2002
Last sequence update: June 1, 2001
Last modified: November 30, 2016
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.