Q9BXF3 (CECR2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cat eye syndrome critical region protein 2

Gene names

Name:	CECR2
Synonyms:	KIAA1740

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1484 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Part of the CERF (CECR2-containing-remodeling factor) complex, which facilitates the perturbation of chromatin structure in an ATP-dependent manner. May be involved through its interaction with LRPPRC in the integration of cytoskeletal network with vesicular trafficking, nucleocytosolic shuttling, transcription, chromosome remodeling and cytokinesis. Ref.7
Subunit structure	Part of the CECR2-containing remodeling factor (CERF) complex which contains CECR2 and SMARCA1. Interacts with acetylated lysine residues on histone H2A and H3 (in vitro). Interacts with LRPPRC. Ref.6 Ref.7 Ref.9
Tissue specificity	Highly expressed in skeletal muscle, thymus, placenta and lung. Expressed at lower level in brain, heart, colon, spleen, kidney.
Miscellaneous	Candidate gene for the Cat Eye Syndrome (CES), a developmental disorder associated with the duplication of a 2 Mb region of 22q11.2. Duplication usually takes in the form of a surpernumerary bisatellited isodicentric chromosome, resulting in four copies of the region (represents an inv dup22(q11)). CES is characterized clinically by the combination of coloboma of the iris and anal atresia with fistula, downslanting palpebral fissures, preauricular tags and/or pits, frequent occurrence of heart and renal malformations, and normal or near-normal mental development.
Sequence similarities	Contains 1 bromo domain.
Sequence caution	The sequence CAH56122.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. The sequence CAH56212.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. The sequence EAW57756.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Bromodomain
Molecular function	Chromatin regulator
PTM	Phosphoprotein
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	ATP-dependent chromatin remodeling Inferred from direct assay Ref.7. Source: MGI apoptotic DNA fragmentation Traceable author statement PubMed 12762840. Source: HGNC cytokinesis Non-traceable author statement Ref.6. Source: UniProtKB cytoskeleton organization Non-traceable author statement Ref.6. Source: UniProtKB neural tube development Inferred from electronic annotation. Source: Compara vesicle-mediated transport Non-traceable author statement Ref.6. Source: UniProtKB
Cellular_component	CERF complex Inferred from direct assay Ref.7. Source: MGI nuclear euchromatin Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform A (identifier: Q9BXF3-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform B (identifier: Q9BXF3-2)

Also known as: CECR2B;

The sequence of this isoform differs from the canonical sequence as follows:
     291-318: Missing.
     519-526: EYTKMSDN → GKQGRSLC
     527-1484: Missing.

Isoform C (identifier: Q9BXF3-3)

The sequence of this isoform differs from the canonical sequence as follows:
     370-389: Missing.

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 1484

1484

Cat eye syndrome critical region protein 2

PRO_0000211192

Regions

Domain

451 – 521

71

Bromo

Compositional bias

333 – 337

5

Poly-Glu

Compositional bias

611 – 614

4

Poly-Ser

Compositional bias

1250 – 1253

4

Poly-Pro

Amino acid modifications

Modified residue

422

1

Phosphoserine Ref.8

Modified residue

546

1

Phosphothreonine Ref.8

Modified residue

571

1

Phosphoserine Ref.8

Modified residue

1014

1

Phosphoserine Ref.8

Modified residue

1312

1

Phosphoserine Ref.8

Natural variations

Alternative sequence

291 – 318

28

Missing in isoform B.

VSP_000571

Alternative sequence

370 – 389

20

Missing in isoform C.

VSP_020407

Alternative sequence

519 – 526

8

EYTKMSDN → GKQGRSLC in isoform B.

VSP_000572

Alternative sequence

527 – 1484

958

Missing in isoform B.

VSP_000573

Natural variant

293

1

R → H.
Corresponds to variant rs5747211 [ dbSNP | Ensembl ].

VAR_027411

Natural variant

674

1

P → L. Ref.1 Ref.5
Corresponds to variant rs1296794 [ dbSNP | Ensembl ].

VAR_027412

Experimental info

Sequence conflict

352

1

M → I in CAH56122. Ref.4

Sequence conflict

352

1

M → I in CAH56212. Ref.4

Sequence conflict

1029

1

S → C in AAK15343. Ref.1

Sequence conflict

1045

1

W → R in AAK15343. Ref.1

Sequence conflict

1441

1

M → T in CAH56122. Ref.4

Sequence conflict

1441

1

M → T in CAH56212. Ref.4

Secondary structure

1

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

1484

Helix Strand Turn

Details...

Helix

439 – 452

14

Helix

457 – 459

3

Turn

465 – 467

3

Helix

471 – 474

4

Helix

481 – 489

9

Helix

496 – 514

19

Helix

519 – 536

18

Sequences

	Sequence		Length	Mass (Da)
	Isoform A [UniParc]. Last modified September 5, 2006. Version 2. Checksum: 8680DB16A0B90D0D	FASTA	1,484	164,213
	10 20 30 40 50 60 MCPEEGGAAG LGELRSWWEV PAIAHFCSLF RTAFRLPDFE IEELEAALHR DDVEFISDLI 70 80 90 100 110 120 ACLLQGCYQR RDITPQTFHS YLEDIINYRW ELEEGKPNPL REASFQDLPL RTRVEILHRL 130 140 150 160 170 180 CDYRLDADDV FDLLKGLDAD SLRVEPLGED NSGALYWYFY GTRMYKEDPV QGKSNGELSL 190 200 210 220 230 240 SRESEGQKNV SSIPGKTGKR RGRPPKRKKL QEEILLSEKQ EENSLASEPQ TRHGSQGPGQ 250 260 270 280 290 300 GTWWLLCQTE EEWRQVTESF RERTSLRERQ LYKLLSEDFL PEICNMIAQK GKRPQRTKAE 310 320 330 340 350 360 LHPRWMSDHL SIKPVKQEET PVLTRIEKQK RKEEEEERQI LLAVQKKEQE QMLKEERKRE 370 380 390 400 410 420 LEEKVKAVEG MCSVRVVWRG ACLSTSRPVD RAKRRKLREE RAWLLAQGKE LPPELSHLDP 430 440 450 460 470 480 NSPMREEKKT KDLFELDDDF TAMYKVLDVV KAHKDSWPFL EPVDESYAPN YYQIIKAPMD 490 500 510 520 530 540 ISSMEKKLNG GLYCTKEEFV NDMKTMFRNC RKYNGESSEY TKMSDNLERC FHRAMMKHFP 550 560 570 580 590 600 GEDGDTDEEF WIREDEKREK RRSRAGRSGG SHVWTRSRDP EGSSRKQQPM ENGGKSLPPT 610 620 630 640 650 660 RRAPSSGDDQ SSSSTQPPRE VGTSNGRGFS HPLHCGGTPS QAPFLNQMRP AVPGTFGPLR 670 680 690 700 710 720 GSDPATLYGS SGVPEPHPGE PVQQRQPFTM QPPVGINSLR GPRLGTPEEK QMCGGLTHLS 730 740 750 760 770 780 NMGPHPGSLQ LGQISGPSQD GSMYAPAQFQ PGFIPPRHGG APARPPDFPE SSEIPPSHMY 790 800 810 820 830 840 RSYKYLNRVH SAVWNGNHGA TNQGPLGPDE KPHLGPGPSH QPRTLGHVMD SRVMRPPVPP 850 860 870 880 890 900 NQWTEQSGFL PHGVPSSGYM RPPCKSAGHR LQPPPVPAPS SLFGAPAQAL RGVQGGDSMM 910 920 930 940 950 960 DSPEMIAMQQ LSSRVCPPGV PYHPHQPAHP RLPGPFPQVA HPMSVTVSAP KPALGNPGRA 970 980 990 1000 1010 1020 PENSEAQEPE NDQAEPLPGL EEKPPGVGTS EGVYLTQLPH PTPPLQTDCT RQSSPQERET 1030 1040 1050 1060 1070 1080 VGPELKSSSS ESADNCKAMK GKNPWPSDSS YPGPAAQGCV RDLSTVADRG ALSENGVIGE 1090 1100 1110 1120 1130 1140 ASPCGSEGKG LGSSGSEKLL CPRGRTLQET MPCTGQNAAT PPSTDPGLTG GTVSQFPPLY 1150 1160 1170 1180 1190 1200 MPGLEYPNSA AHYHISPGLQ GVGPVMGGKS PASHPQHFPP RGFQSNHPHS GGFPRYRPPQ 1210 1220 1230 1240 1250 1260 GMRYSYHPPP QPSYHHYQRT PYYACPQSFS DWQRPLHPQG SPSGPPASQP PPPRSLFSDK 1270 1280 1290 1300 1310 1320 NAMASLQGCE TLNAALTSPT RMDAVAAKVP NDGQNPGPEE EKLDESMERP ESPKEFLDLD 1330 1340 1350 1360 1370 1380 NHNAATKRQS SLSASEYLYG TPPPLSSGMG FGSSAFPPHS VMLQTGPPYT PQRPASHFQP 1390 1400 1410 1420 1430 1440 RAYSSPVAAL PPHHPGATQP NGLSQEGPIY RCQEEGLGHF QAVMMEQIGT RSGIRGPFQE 1450 1460 1470 1480 MYRPSGMQMH PVQSQASFPK TPTAATSQEE VPPHKPPTLP LDQS
	Isoform B (CECR2B) [UniParc]. Checksum: 40A2A890E9B5B9D6	FASTA	498	58,108
	10 20 30 40 50 60 MCPEEGGAAG LGELRSWWEV PAIAHFCSLF RTAFRLPDFE IEELEAALHR DDVEFISDLI 70 80 90 100 110 120 ACLLQGCYQR RDITPQTFHS YLEDIINYRW ELEEGKPNPL REASFQDLPL RTRVEILHRL 130 140 150 160 170 180 CDYRLDADDV FDLLKGLDAD SLRVEPLGED NSGALYWYFY GTRMYKEDPV QGKSNGELSL 190 200 210 220 230 240 SRESEGQKNV SSIPGKTGKR RGRPPKRKKL QEEILLSEKQ EENSLASEPQ TRHGSQGPGQ 250 260 270 280 290 300 GTWWLLCQTE EEWRQVTESF RERTSLRERQ LYKLLSEDFL PEICNMIAQK ETPVLTRIEK 310 320 330 340 350 360 QKRKEEEEER QILLAVQKKE QEQMLKEERK RELEEKVKAV EGMCSVRVVW RGACLSTSRP 370 380 390 400 410 420 VDRAKRRKLR EERAWLLAQG KELPPELSHL DPNSPMREEK KTKDLFELDD DFTAMYKVLD 430 440 450 460 470 480 VVKAHKDSWP FLEPVDESYA PNYYQIIKAP MDISSMEKKL NGGLYCTKEE FVNDMKTMFR 490 NCRKYNGESS GKQGRSLC
	Isoform C [UniParc]. Checksum: 3321852BA97D5481	FASTA	1,464	162,067
	10 20 30 40 50 60 MCPEEGGAAG LGELRSWWEV PAIAHFCSLF RTAFRLPDFE IEELEAALHR DDVEFISDLI 70 80 90 100 110 120 ACLLQGCYQR RDITPQTFHS YLEDIINYRW ELEEGKPNPL REASFQDLPL RTRVEILHRL 130 140 150 160 170 180 CDYRLDADDV FDLLKGLDAD SLRVEPLGED NSGALYWYFY GTRMYKEDPV QGKSNGELSL 190 200 210 220 230 240 SRESEGQKNV SSIPGKTGKR RGRPPKRKKL QEEILLSEKQ EENSLASEPQ TRHGSQGPGQ 250 260 270 280 290 300 GTWWLLCQTE EEWRQVTESF RERTSLRERQ LYKLLSEDFL PEICNMIAQK GKRPQRTKAE 310 320 330 340 350 360 LHPRWMSDHL SIKPVKQEET PVLTRIEKQK RKEEEEERQI LLAVQKKEQE QMLKEERKRE 370 380 390 400 410 420 LEEKVKAVED RAKRRKLREE RAWLLAQGKE LPPELSHLDP NSPMREEKKT KDLFELDDDF 430 440 450 460 470 480 TAMYKVLDVV KAHKDSWPFL EPVDESYAPN YYQIIKAPMD ISSMEKKLNG GLYCTKEEFV 490 500 510 520 530 540 NDMKTMFRNC RKYNGESSEY TKMSDNLERC FHRAMMKHFP GEDGDTDEEF WIREDEKREK 550 560 570 580 590 600 RRSRAGRSGG SHVWTRSRDP EGSSRKQQPM ENGGKSLPPT RRAPSSGDDQ SSSSTQPPRE 610 620 630 640 650 660 VGTSNGRGFS HPLHCGGTPS QAPFLNQMRP AVPGTFGPLR GSDPATLYGS SGVPEPHPGE 670 680 690 700 710 720 PVQQRQPFTM QPPVGINSLR GPRLGTPEEK QMCGGLTHLS NMGPHPGSLQ LGQISGPSQD 730 740 750 760 770 780 GSMYAPAQFQ PGFIPPRHGG APARPPDFPE SSEIPPSHMY RSYKYLNRVH SAVWNGNHGA 790 800 810 820 830 840 TNQGPLGPDE KPHLGPGPSH QPRTLGHVMD SRVMRPPVPP NQWTEQSGFL PHGVPSSGYM 850 860 870 880 890 900 RPPCKSAGHR LQPPPVPAPS SLFGAPAQAL RGVQGGDSMM DSPEMIAMQQ LSSRVCPPGV 910 920 930 940 950 960 PYHPHQPAHP RLPGPFPQVA HPMSVTVSAP KPALGNPGRA PENSEAQEPE NDQAEPLPGL 970 980 990 1000 1010 1020 EEKPPGVGTS EGVYLTQLPH PTPPLQTDCT RQSSPQERET VGPELKSSSS ESADNCKAMK 1030 1040 1050 1060 1070 1080 GKNPWPSDSS YPGPAAQGCV RDLSTVADRG ALSENGVIGE ASPCGSEGKG LGSSGSEKLL 1090 1100 1110 1120 1130 1140 CPRGRTLQET MPCTGQNAAT PPSTDPGLTG GTVSQFPPLY MPGLEYPNSA AHYHISPGLQ 1150 1160 1170 1180 1190 1200 GVGPVMGGKS PASHPQHFPP RGFQSNHPHS GGFPRYRPPQ GMRYSYHPPP QPSYHHYQRT 1210 1220 1230 1240 1250 1260 PYYACPQSFS DWQRPLHPQG SPSGPPASQP PPPRSLFSDK NAMASLQGCE TLNAALTSPT 1270 1280 1290 1300 1310 1320 RMDAVAAKVP NDGQNPGPEE EKLDESMERP ESPKEFLDLD NHNAATKRQS SLSASEYLYG 1330 1340 1350 1360 1370 1380 TPPPLSSGMG FGSSAFPPHS VMLQTGPPYT PQRPASHFQP RAYSSPVAAL PPHHPGATQP 1390 1400 1410 1420 1430 1440 NGLSQEGPIY RCQEEGLGHF QAVMMEQIGT RSGIRGPFQE MYRPSGMQMH PVQSQASFPK 1450 1460 TPTAATSQEE VPPHKPPTLP LDQS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Analysis of the cat eye syndrome critical region in humans and the region of conserved synteny in mice: a search for candidate genes at or near the human chromosome 22 pericentromere." Footz T.K., Brinkman-Mills P., Banting G.S., Maier S.A., Riazi M.A., Bridgland L.J., Hu S., Birren B., Minoshima S., Shimizu N., Pan H., Nguyen T., Fang F., Fu Y., Ray L., Wu H., Shaull S., Phan S. , Yao Z., Chen F., Huan A., Hu P., Wang Q., Loh P., Qi S., Roe B.A., McDermid H.E. Genome Res. 11:1053-1070(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A), VARIANT LEU-674.
[2]	"The DNA sequence of human chromosome 22." Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M. , Buck D., Burgess J., Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A., Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C., Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L., Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L., Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N., Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R., Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y., Wright H. Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 36-1484 (ISOFORM C). Tissue: Skeletal muscle.
[5]	"Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." Nagase T., Kikuno R., Hattori A., Kondo Y., Okumura K., Ohara O. DNA Res. 7:347-355(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 346-1484 (ISOFORM C), VARIANT LEU-674. Tissue: Brain.
[6]	"Sequence analysis of LRPPRC and its SEC1 domain interaction partners suggests roles in cytoskeletal organization, vesicular trafficking, nucleocytosolic shuttling, and chromosome activity." Liu L., McKeehan W.L. Genomics 79:124-136(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 168-1484 (ISOFORM B), INTERACTION WITH LRPPRC. Tissue: Liver.
[7]	"CECR2, a protein involved in neurulation, forms a novel chromatin remodeling complex with SNF2L." Banting G.S., Barak O., Ames T.M., Burnham A.C., Kardel M.D., Cooch N.S., Davidson C.E., Godbout R., McDermid H.E., Shiekhattar R. Hum. Mol. Genet. 14:513-524(2005) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, IDENTIFICATION IN THE CERF COMPLEX, MASS SPECTROMETRY.
[8]	"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation." Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B. Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-422; THR-546; SER-571; SER-1014 AND SER-1312, MASS SPECTROMETRY.
[9]	"Histone recognition and large-scale structural analysis of the human bromodomain family." Filippakopoulos P., Picaud S., Mangos M., Keates T., Lambert J.P., Barsyte-Lovejoy D., Felletar I., Volkmer R., Muller S., Pawson T., Gingras A.C., Arrowsmith C.H., Knapp S. Cell 149:214-231(2012) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (1.83 ANGSTROMS) OF 424-538, SUBUNIT.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AF336133 mRNA. Translation: AAK15343.1.
AC004019 Genomic DNA. No translation available.
CH471193 Genomic DNA. Translation: EAW57756.1. Different initiation.
BX647449 mRNA. Translation: CAH56122.1. Different initiation.
AL832377 mRNA. Translation: CAH56212.1. Different initiation.
AB051527 mRNA. Translation: BAB21831.1.
AF411609 mRNA. Translation: AAL07393.1.

IPI

IPI00215838.
IPI00785169.
IPI00848350.

RefSeq

NP_113601.2. NM_031413.3.

UniGene

Hs.658723.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
3NXB	X-ray	1.83	A/B	424-538	[»]

ProteinModelPortal

Q9BXF3.

ModBase

Search...

Protein-protein interaction databases

STRING

9606.ENSP00000262608.

PTM databases

PhosphoSite

Q9BXF3.

Polymorphism databases

DMDM

114152782.

Proteomic databases

PaxDb

Q9BXF3.

PRIDE

Q9BXF3.

Protocols and materials databases

DNASU

27443.

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000262608; ENSP00000262608; ENSG00000099954.

GeneID

27443.

KEGG

hsa:27443.

UCSC

uc010gqw.1. human.

Organism-specific databases

CTD

27443.

GeneCards

GC22P017840.

H-InvDB

HIX0023032.

HGNC

HGNC:1840. CECR2.

HPA

HPA002943.

MIM

607576. gene.

neXtProt

NX_Q9BXF3.

Orphanet

195. Cat-eye syndrome.

PharmGKB

PA26383.

HUGE

Search...

GenAtlas

Search...

Phylogenomic databases

eggNOG

COG5076.

HOGENOM

HOG000081808.

HOVERGEN

HBG081078.

Gene expression databases

ArrayExpress

Q9BXF3.

Bgee

Q9BXF3.

CleanEx

HS_CECR2.

Genevestigator

Q9BXF3.

GermOnline

ENSG00000099954. Homo sapiens.

Family and domain databases

Gene3D

1.20.920.10. 1 hit.

InterPro

IPR001487. Bromodomain.
IPR018359. Bromodomain_CS.
[Graphical view]

Pfam

PF00439. Bromodomain. 1 hit.
[Graphical view]

PRINTS

PR00503. BROMODOMAIN.

SMART

SM00297. BROMO. 1 hit.
[Graphical view]

SUPFAM

SSF47370. Bromodomain. 1 hit.

PROSITE

PS00633. BROMODOMAIN_1. 1 hit.
PS50014. BROMODOMAIN_2. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

ChiTaRS

CECR2. human.

EvolutionaryTrace

Q9BXF3.

GenomeRNAi

27443.

NextBio

50516.

SOURCE

Search...

Entry information

Entry name

CECR2_HUMAN

Accession

Primary (citable) accession number: Q9BXF3
Secondary accession number(s): A8MS90 , A8MX16, Q658Z4, Q96P58, Q9C0C3

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 16, 2002
Last sequence update:	September 5, 2006
Last modified:	May 1, 2013
This is version 100 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.