ID VN1R3_HUMAN Reviewed; 311 AA. AC Q9BXE9; DT 05-JUL-2005, integrated into UniProtKB/Swiss-Prot. DT 01-JUN-2001, sequence version 1. DT 27-MAR-2024, entry version 109. DE RecName: Full=Vomeronasal type-1 receptor 3; DE AltName: Full=V1r-like receptor 3; GN Name=VN1R3; Synonyms=V1RL3; ORFNames=FKSG46; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RA Wang Y.-G., Gong L.; RT "Cloning and characterization of FKSG46, a novel gene located on human RT chromosome 16."; RL Submitted (JAN-2001) to the EMBL/GenBank/DDBJ databases. RN [2] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX PubMed=12123587; DOI=10.1016/s0960-9822(02)00909-0; RA Rodriguez I., Mombaerts P.; RT "Novel human vomeronasal receptor-like genes reveal species-specific RT families."; RL Curr. Biol. 12:R409-R411(2002). RN [3] RP DISCUSSION OF POLYMORPHISM. RX PubMed=12826614; DOI=10.1073/pnas.1331721100; RA Zhang J., Webb D.M.; RT "Evolutionary deterioration of the vomeronasal pheromone transduction RT pathway in catarrhine primates."; RL Proc. Natl. Acad. Sci. U.S.A. 100:8337-8341(2003). CC -!- FUNCTION: Putative pheromone receptor. CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. CC -!- POLYMORPHISM: There seems to be a deletion in the gene coding for this CC protein in about 98% of the population. {ECO:0000305|PubMed:12826614}. CC -!- MISCELLANEOUS: The gorilla and orangutan orthologous proteins do not CC exist, their genes are pseudogenes. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC {ECO:0000255|PROSITE-ProRule:PRU00521}. CC -!- WEB RESOURCE: Name=Protein Spotlight; Note=No one nose - Issue 61 of CC August 2005; CC URL="https://web.expasy.org/spotlight/back_issues/061"; CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AF336873; AAK21299.1; -; mRNA. DR RefSeq; NP_778145.2; NM_174980.2. DR AlphaFoldDB; Q9BXE9; -. DR SMR; Q9BXE9; -. DR GlyCosmos; Q9BXE9; 1 site, No reported glycans. DR GlyGen; Q9BXE9; 1 site. DR BioMuta; HGNC:19867; -. DR DMDM; 68566227; -. DR jPOST; Q9BXE9; -. DR DNASU; 317702; -. DR GeneID; 317702; -. DR KEGG; hsa:317702; -. DR AGR; HGNC:19867; -. DR GeneCards; VN1R3; -. DR HGNC; HGNC:19867; VN1R3. DR neXtProt; NX_Q9BXE9; -. DR InParanoid; Q9BXE9; -. DR PhylomeDB; Q9BXE9; -. DR PathwayCommons; Q9BXE9; -. DR BioGRID-ORCS; 317702; 0 hits in 1 CRISPR screen. DR GenomeRNAi; 317702; -. DR Pharos; Q9BXE9; Tdark. DR PRO; PR:Q9BXE9; -. DR Proteomes; UP000005640; Unplaced. DR RNAct; Q9BXE9; Protein. DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. DR GO; GO:0016503; F:pheromone receptor activity; IEA:InterPro. DR GO; GO:0019236; P:response to pheromone; IEA:UniProtKB-KW. DR GO; GO:0007606; P:sensory perception of chemical stimulus; IEA:UniProt. DR CDD; cd13949; 7tm_V1R_pheromone; 1. DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1. DR InterPro; IPR017452; GPCR_Rhodpsn_7TM. DR InterPro; IPR004072; Vmron_rcpt_1. DR PANTHER; PTHR24062; VOMERONASAL TYPE-1 RECEPTOR; 1. DR PANTHER; PTHR24062:SF146; VOMERONASAL TYPE-1 RECEPTOR 3; 1. DR Pfam; PF03402; V1R; 1. DR PRINTS; PR01534; VOMERONASL1R. DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. PE 2: Evidence at transcript level; KW Cell membrane; G-protein coupled receptor; Glycoprotein; Membrane; KW Pheromone response; Receptor; Reference proteome; Transducer; KW Transmembrane; Transmembrane helix. FT CHAIN 1..311 FT /note="Vomeronasal type-1 receptor 3" FT /id="PRO_0000070215" FT TOPO_DOM 1..5 FT /note="Extracellular" FT /evidence="ECO:0000255" FT TRANSMEM 6..26 FT /note="Helical; Name=1" FT /evidence="ECO:0000255" FT TOPO_DOM 27..51 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT TRANSMEM 52..72 FT /note="Helical; Name=2" FT /evidence="ECO:0000255" FT TOPO_DOM 73..92 FT /note="Extracellular" FT /evidence="ECO:0000255" FT TRANSMEM 93..113 FT /note="Helical; Name=3" FT /evidence="ECO:0000255" FT TOPO_DOM 114..130 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT TRANSMEM 131..151 FT /note="Helical; Name=4" FT /evidence="ECO:0000255" FT TOPO_DOM 152..187 FT /note="Extracellular" FT /evidence="ECO:0000255" FT TRANSMEM 188..208 FT /note="Helical; Name=5" FT /evidence="ECO:0000255" FT TOPO_DOM 209..232 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT TRANSMEM 233..249 FT /note="Helical; Name=6" FT /evidence="ECO:0000255" FT TOPO_DOM 250..264 FT /note="Extracellular" FT /evidence="ECO:0000255" FT TRANSMEM 265..285 FT /note="Helical; Name=7" FT /evidence="ECO:0000255" FT TOPO_DOM 286..311 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT CARBOHYD 159 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255" SQ SEQUENCE 311 AA; 34713 MW; B310408A12160DBD CRC64; MASKDFAIGM ILLSQIMVGF LGNFFLLYHY SFLCFTRGML QSTDLILKHL TIANSLVILS KGIPQTMAAF GLKDSLSDIG CKFVFYVHRV GRAVCVGNAC LLSVFQVITI SPSEFRWAEL KLHAHKYIRS FILVLCWILN TLVNITVLLH VTGKWNSINS TKTNDYGYCS GGSRSRIPHS LHIVLLSSLD VLCLGLMTLA SGSMVFILHR HKQQVQHIHG TNLSARSSPE SRVTQSILVL VSTLCYFTRS PPSLHMSLFP NPSWWLLNTS ALITACFPMV SPFVLMSRHP RIPRLGSACC GRNPQFPKLV R //