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Q9BXE9

- VN1R3_HUMAN

UniProt

Q9BXE9 - VN1R3_HUMAN

Protein

Vomeronasal type-1 receptor 3

Gene

VN1R3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 70 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
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    Functioni

    Putative pheromone receptor.

    GO - Molecular functioni

    1. pheromone receptor activity Source: InterPro

    GO - Biological processi

    1. response to pheromone Source: UniProtKB-KW

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Pheromone response

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Vomeronasal type-1 receptor 3
    Alternative name(s):
    V1r-like receptor 3
    Gene namesi
    Name:VN1R3
    Synonyms:V1RL3
    ORF Names:FKSG46
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Unplaced

    Organism-specific databases

    HGNCiHGNC:19867. VN1R3.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 311311Vomeronasal type-1 receptor 3PRO_0000070215Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi159 – 1591N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PRIDEiQ9BXE9.

    Expressioni

    Gene expression databases

    CleanExiHS_VN1R3.
    GenevestigatoriQ9BXE9.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9BXE9.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 55ExtracellularSequence Analysis
    Topological domaini27 – 5125CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini73 – 9220ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini114 – 13017CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini152 – 18736ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini209 – 23224CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini250 – 26415ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini286 – 31126CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei6 – 2621Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei52 – 7221Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei93 – 11321Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei131 – 15121Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei188 – 20821Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei233 – 24917Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei265 – 28521Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    HOVERGENiHBG073430.
    PhylomeDBiQ9BXE9.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR017452. GPCR_Rhodpsn_7TM.
    IPR004072. Vmron_rcpt_1.
    [Graphical view]
    PfamiPF03402. V1R. 1 hit.
    [Graphical view]
    PRINTSiPR01534. VOMERONASL1R.
    PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9BXE9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MASKDFAIGM ILLSQIMVGF LGNFFLLYHY SFLCFTRGML QSTDLILKHL    50
    TIANSLVILS KGIPQTMAAF GLKDSLSDIG CKFVFYVHRV GRAVCVGNAC 100
    LLSVFQVITI SPSEFRWAEL KLHAHKYIRS FILVLCWILN TLVNITVLLH 150
    VTGKWNSINS TKTNDYGYCS GGSRSRIPHS LHIVLLSSLD VLCLGLMTLA 200
    SGSMVFILHR HKQQVQHIHG TNLSARSSPE SRVTQSILVL VSTLCYFTRS 250
    PPSLHMSLFP NPSWWLLNTS ALITACFPMV SPFVLMSRHP RIPRLGSACC 300
    GRNPQFPKLV R 311
    Length:311
    Mass (Da):34,713
    Last modified:June 1, 2001 - v1
    Checksum:iB310408A12160DBD
    GO

    Polymorphismi

    There seems to be a deletion in the gene coding for this protein in about 98% of the population.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF336873 mRNA. Translation: AAK21299.1.
    UniGeneiHs.257746.

    Polymorphism databases

    DMDMi68566227.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Protein Spotlight

    No one nose - Issue 61 of August 2005

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF336873 mRNA. Translation: AAK21299.1 .
    UniGenei Hs.257746.

    3D structure databases

    ProteinModelPortali Q9BXE9.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    GPCRDBi Search...

    Polymorphism databases

    DMDMi 68566227.

    Proteomic databases

    PRIDEi Q9BXE9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    GeneCardsi GC16M031818.
    H-InvDB HIX0038719.
    HGNCi HGNC:19867. VN1R3.
    neXtProti NX_Q9BXE9.
    GenAtlasi Search...

    Phylogenomic databases

    HOVERGENi HBG073430.
    PhylomeDBi Q9BXE9.

    Miscellaneous databases

    PROi Q9BXE9.

    Gene expression databases

    CleanExi HS_VN1R3.
    Genevestigatori Q9BXE9.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR017452. GPCR_Rhodpsn_7TM.
    IPR004072. Vmron_rcpt_1.
    [Graphical view ]
    Pfami PF03402. V1R. 1 hit.
    [Graphical view ]
    PRINTSi PR01534. VOMERONASL1R.
    PROSITEi PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and characterization of FKSG46, a novel gene located on human chromosome 16."
      Wang Y.-G., Gong L.
      Submitted (JAN-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Novel human vomeronasal receptor-like genes reveal species-specific families."
      Rodriguez I., Mombaerts P.
      Curr. Biol. 12:R409-R411(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "Evolutionary deterioration of the vomeronasal pheromone transduction pathway in catarrhine primates."
      Zhang J., Webb D.M.
      Proc. Natl. Acad. Sci. U.S.A. 100:8337-8341(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: DISCUSSION OF POLYMORPHISM.

    Entry informationi

    Entry nameiVN1R3_HUMAN
    AccessioniPrimary (citable) accession number: Q9BXE9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 5, 2005
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 70 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    The gorilla and orangutan orthologous proteins do not exist, their genes are pseudogenes.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 16
      Human chromosome 16: entries, gene names and cross-references to MIM
    3. Protein Spotlight
      Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3