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Protein

Vomeronasal type-1 receptor 3

Gene

VN1R3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Putative pheromone receptor.

GO - Molecular functioni

  1. pheromone receptor activity Source: InterPro

GO - Biological processi

  1. response to pheromone Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Pheromone response

Names & Taxonomyi

Protein namesi
Recommended name:
Vomeronasal type-1 receptor 3
Alternative name(s):
V1r-like receptor 3
Gene namesi
Name:VN1R3
Synonyms:V1RL3
ORF Names:FKSG46
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Unplaced

Organism-specific databases

HGNCiHGNC:19867. VN1R3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 55ExtracellularSequence Analysis
Transmembranei6 – 2621Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini27 – 5125CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei52 – 7221Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini73 – 9220ExtracellularSequence AnalysisAdd
BLAST
Transmembranei93 – 11321Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini114 – 13017CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei131 – 15121Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini152 – 18736ExtracellularSequence AnalysisAdd
BLAST
Transmembranei188 – 20821Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini209 – 23224CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei233 – 24917Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini250 – 26415ExtracellularSequence AnalysisAdd
BLAST
Transmembranei265 – 28521Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini286 – 31126CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 311311Vomeronasal type-1 receptor 3PRO_0000070215Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi159 – 1591N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiQ9BXE9.

Expressioni

Gene expression databases

CleanExiHS_VN1R3.
GenevestigatoriQ9BXE9.

Structurei

3D structure databases

ProteinModelPortaliQ9BXE9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG073430.
InParanoidiQ9BXE9.
PhylomeDBiQ9BXE9.

Family and domain databases

InterProiIPR017452. GPCR_Rhodpsn_7TM.
IPR004072. Vmron_rcpt_1.
[Graphical view]
PfamiPF03402. V1R. 1 hit.
[Graphical view]
PRINTSiPR01534. VOMERONASL1R.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9BXE9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MASKDFAIGM ILLSQIMVGF LGNFFLLYHY SFLCFTRGML QSTDLILKHL
60 70 80 90 100
TIANSLVILS KGIPQTMAAF GLKDSLSDIG CKFVFYVHRV GRAVCVGNAC
110 120 130 140 150
LLSVFQVITI SPSEFRWAEL KLHAHKYIRS FILVLCWILN TLVNITVLLH
160 170 180 190 200
VTGKWNSINS TKTNDYGYCS GGSRSRIPHS LHIVLLSSLD VLCLGLMTLA
210 220 230 240 250
SGSMVFILHR HKQQVQHIHG TNLSARSSPE SRVTQSILVL VSTLCYFTRS
260 270 280 290 300
PPSLHMSLFP NPSWWLLNTS ALITACFPMV SPFVLMSRHP RIPRLGSACC
310
GRNPQFPKLV R
Length:311
Mass (Da):34,713
Last modified:June 1, 2001 - v1
Checksum:iB310408A12160DBD
GO

Polymorphismi

There seems to be a deletion in the gene coding for this protein in about 98% of the population.

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF336873 mRNA. Translation: AAK21299.1.
UniGeneiHs.257746.

Polymorphism databases

DMDMi68566227.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Protein Spotlight

No one nose - Issue 61 of August 2005

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF336873 mRNA. Translation: AAK21299.1.
UniGeneiHs.257746.

3D structure databases

ProteinModelPortaliQ9BXE9.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

GPCRDBiSearch...

Polymorphism databases

DMDMi68566227.

Proteomic databases

PRIDEiQ9BXE9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

GeneCardsiGC16M031818.
H-InvDBHIX0038719.
HGNCiHGNC:19867. VN1R3.
neXtProtiNX_Q9BXE9.
GenAtlasiSearch...

Phylogenomic databases

HOVERGENiHBG073430.
InParanoidiQ9BXE9.
PhylomeDBiQ9BXE9.

Miscellaneous databases

PROiQ9BXE9.

Gene expression databases

CleanExiHS_VN1R3.
GenevestigatoriQ9BXE9.

Family and domain databases

InterProiIPR017452. GPCR_Rhodpsn_7TM.
IPR004072. Vmron_rcpt_1.
[Graphical view]
PfamiPF03402. V1R. 1 hit.
[Graphical view]
PRINTSiPR01534. VOMERONASL1R.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Cloning and characterization of FKSG46, a novel gene located on human chromosome 16."
    Wang Y.-G., Gong L.
    Submitted (JAN-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Novel human vomeronasal receptor-like genes reveal species-specific families."
    Rodriguez I., Mombaerts P.
    Curr. Biol. 12:R409-R411(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Evolutionary deterioration of the vomeronasal pheromone transduction pathway in catarrhine primates."
    Zhang J., Webb D.M.
    Proc. Natl. Acad. Sci. U.S.A. 100:8337-8341(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: DISCUSSION OF POLYMORPHISM.

Entry informationi

Entry nameiVN1R3_HUMAN
AccessioniPrimary (citable) accession number: Q9BXE9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: June 1, 2001
Last modified: January 7, 2015
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

The gorilla and orangutan orthologous proteins do not exist, their genes are pseudogenes.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  3. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.