Q9BXE9 (VN1R3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Vomeronasal type-1 receptor 3

Alternative name(s):
V1r-like receptor 3

Gene names

Name:	VN1R3
Synonyms:	V1RL3
ORF Names:	FKSG46

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	311 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Putative pheromone receptor.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Polymorphism	There seems to be a deletion in the gene coding for this protein in about 98% of the population.
Miscellaneous	The gorilla and orangutan orthologous proteins do not exist, their genes are pseudogenes.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
Biological process	Pheromone response
Cellular component	Cell membrane Membrane
Coding sequence diversity	Polymorphism
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	response to pheromone Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	pheromone receptor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 311	311	Vomeronasal type-1 receptor 3		PRO_0000070215
Regions
	Topological domain	1 – 5	5	Extracellular Potential
	Transmembrane	6 – 26	21	Helical; Name=1; Potential
	Topological domain	27 – 51	25	Cytoplasmic Potential
	Transmembrane	52 – 72	21	Helical; Name=2; Potential
	Topological domain	73 – 92	20	Extracellular Potential
	Transmembrane	93 – 113	21	Helical; Name=3; Potential
	Topological domain	114 – 130	17	Cytoplasmic Potential
	Transmembrane	131 – 151	21	Helical; Name=4; Potential
	Topological domain	152 – 187	36	Extracellular Potential
	Transmembrane	188 – 208	21	Helical; Name=5; Potential
	Topological domain	209 – 232	24	Cytoplasmic Potential
	Transmembrane	233 – 249	17	Helical; Name=6; Potential
	Topological domain	250 – 264	15	Extracellular Potential
	Transmembrane	265 – 285	21	Helical; Name=7; Potential
	Topological domain	286 – 311	26	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	159	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	Q9BXE9 [UniParc]. Last modified June 1, 2001. Version 1. Checksum: B310408A12160DBD	FASTA	311	34,713
	10 20 30 40 50 60 MASKDFAIGM ILLSQIMVGF LGNFFLLYHY SFLCFTRGML QSTDLILKHL TIANSLVILS 70 80 90 100 110 120 KGIPQTMAAF GLKDSLSDIG CKFVFYVHRV GRAVCVGNAC LLSVFQVITI SPSEFRWAEL 130 140 150 160 170 180 KLHAHKYIRS FILVLCWILN TLVNITVLLH VTGKWNSINS TKTNDYGYCS GGSRSRIPHS 190 200 210 220 230 240 LHIVLLSSLD VLCLGLMTLA SGSMVFILHR HKQQVQHIHG TNLSARSSPE SRVTQSILVL 250 260 270 280 290 300 VSTLCYFTRS PPSLHMSLFP NPSWWLLNTS ALITACFPMV SPFVLMSRHP RIPRLGSACC 310 GRNPQFPKLV R

References

[1]	"Cloning and characterization of FKSG46, a novel gene located on human chromosome 16." Wang Y.-G., Gong L. Submitted (JAN-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Novel human vomeronasal receptor-like genes reveal species-specific families." Rodriguez I., Mombaerts P. Curr. Biol. 12:R409-R411(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"Evolutionary deterioration of the vomeronasal pheromone transduction pathway in catarrhine primates." Zhang J., Webb D.M. Proc. Natl. Acad. Sci. U.S.A. 100:8337-8341(2003) [PubMed] [Europe PMC] [Abstract] Cited for: DISCUSSION OF POLYMORPHISM.

Web resources

Protein Spotlight

No one nose - Issue 61 of August 2005

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF336873 mRNA. Translation: AAK21299.1.
IPI	IPI00000035.
UniGene	Hs.257746.
3D structure databases
ProteinModelPortal	Q9BXE9.
ModBase	Search...
Protein family/group databases
GPCRDB	Search...
Polymorphism databases
DMDM	68566227.
Proteomic databases
PRIDE	Q9BXE9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Organism-specific databases
GeneCards	GC16M031818.
H-InvDB	HIX0038719.
HGNC	HGNC:19867. VN1R3.
neXtProt	NX_Q9BXE9.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	HBG073430.
Gene expression databases
CleanEx	HS_VN1R3.
Genevestigator	Q9BXE9.
Family and domain databases
InterPro	IPR017452. GPCR_Rhodpsn_7TM. IPR004072. Vmron_rcpt_1. [Graphical view]
Pfam	PF03402. V1R. 1 hit. [Graphical view]
PRINTS	PR01534. VOMERONASL1R.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. False negative. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

VN1R3_HUMAN

Accession

Primary (citable) accession number: Q9BXE9

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 5, 2005
Last sequence update:	June 1, 2001
Last modified:	April 3, 2013
This is version 65 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.