Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q9BXE9 (VN1R3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 69. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Vomeronasal type-1 receptor 3
Alternative name(s):
V1r-like receptor 3
Gene names
Name:VN1R3
Synonyms:V1RL3
ORF Names:FKSG46
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length311 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Putative pheromone receptor.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Polymorphism

There seems to be a deletion in the gene coding for this protein in about 98% of the population.

Miscellaneous

The gorilla and orangutan orthologous proteins do not exist, their genes are pseudogenes.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
   Biological processPheromone response
   Cellular componentCell membrane
Membrane
   Coding sequence diversityPolymorphism
   DomainTransmembrane
Transmembrane helix
   Molecular functionG-protein coupled receptor
Receptor
Transducer
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processresponse to pheromone

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

plasma membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionpheromone receptor activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 311311Vomeronasal type-1 receptor 3
PRO_0000070215

Regions

Topological domain1 – 55Extracellular Potential
Transmembrane6 – 2621Helical; Name=1; Potential
Topological domain27 – 5125Cytoplasmic Potential
Transmembrane52 – 7221Helical; Name=2; Potential
Topological domain73 – 9220Extracellular Potential
Transmembrane93 – 11321Helical; Name=3; Potential
Topological domain114 – 13017Cytoplasmic Potential
Transmembrane131 – 15121Helical; Name=4; Potential
Topological domain152 – 18736Extracellular Potential
Transmembrane188 – 20821Helical; Name=5; Potential
Topological domain209 – 23224Cytoplasmic Potential
Transmembrane233 – 24917Helical; Name=6; Potential
Topological domain250 – 26415Extracellular Potential
Transmembrane265 – 28521Helical; Name=7; Potential
Topological domain286 – 31126Cytoplasmic Potential

Amino acid modifications

Glycosylation1591N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q9BXE9 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: B310408A12160DBD

FASTA31134,713
        10         20         30         40         50         60 
MASKDFAIGM ILLSQIMVGF LGNFFLLYHY SFLCFTRGML QSTDLILKHL TIANSLVILS 

        70         80         90        100        110        120 
KGIPQTMAAF GLKDSLSDIG CKFVFYVHRV GRAVCVGNAC LLSVFQVITI SPSEFRWAEL 

       130        140        150        160        170        180 
KLHAHKYIRS FILVLCWILN TLVNITVLLH VTGKWNSINS TKTNDYGYCS GGSRSRIPHS 

       190        200        210        220        230        240 
LHIVLLSSLD VLCLGLMTLA SGSMVFILHR HKQQVQHIHG TNLSARSSPE SRVTQSILVL 

       250        260        270        280        290        300 
VSTLCYFTRS PPSLHMSLFP NPSWWLLNTS ALITACFPMV SPFVLMSRHP RIPRLGSACC 

       310 
GRNPQFPKLV R 

« Hide

References

[1]"Cloning and characterization of FKSG46, a novel gene located on human chromosome 16."
Wang Y.-G., Gong L.
Submitted (JAN-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Novel human vomeronasal receptor-like genes reveal species-specific families."
Rodriguez I., Mombaerts P.
Curr. Biol. 12:R409-R411(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"Evolutionary deterioration of the vomeronasal pheromone transduction pathway in catarrhine primates."
Zhang J., Webb D.M.
Proc. Natl. Acad. Sci. U.S.A. 100:8337-8341(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: DISCUSSION OF POLYMORPHISM.

Web resources

Protein Spotlight

No one nose - Issue 61 of August 2005

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF336873 mRNA. Translation: AAK21299.1.
UniGeneHs.257746.

3D structure databases

ProteinModelPortalQ9BXE9.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

GPCRDBSearch...

Polymorphism databases

DMDM68566227.

Proteomic databases

PRIDEQ9BXE9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

GeneCardsGC16M031818.
H-InvDBHIX0038719.
HGNCHGNC:19867. VN1R3.
neXtProtNX_Q9BXE9.
GenAtlasSearch...

Phylogenomic databases

HOVERGENHBG073430.
PhylomeDBQ9BXE9.

Gene expression databases

CleanExHS_VN1R3.
GenevestigatorQ9BXE9.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR017452. GPCR_Rhodpsn_7TM.
IPR004072. Vmron_rcpt_1.
[Graphical view]
PfamPF03402. V1R. 1 hit.
[Graphical view]
PRINTSPR01534. VOMERONASL1R.
PROSITEPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

PROQ9BXE9.

Entry information

Entry nameVN1R3_HUMAN
AccessionPrimary (citable) accession number: Q9BXE9
Entry history
Integrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: June 1, 2001
Last modified: April 16, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Protein Spotlight

Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries

Human chromosome 16

Human chromosome 16: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries