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Q9BXE9

- VN1R3_HUMAN

UniProt

Q9BXE9 - VN1R3_HUMAN

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Protein
Vomeronasal type-1 receptor 3
Gene
VN1R3, V1RL3, FKSG46
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Putative pheromone receptor.

GO - Molecular functioni

  1. pheromone receptor activity Source: InterPro

GO - Biological processi

  1. response to pheromone Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Pheromone response

Names & Taxonomyi

Protein namesi
Recommended name:
Vomeronasal type-1 receptor 3
Alternative name(s):
V1r-like receptor 3
Gene namesi
Name:VN1R3
Synonyms:V1RL3
ORF Names:FKSG46
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Unplaced

Organism-specific databases

HGNCiHGNC:19867. VN1R3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 55Extracellular Reviewed prediction
Transmembranei6 – 2621Helical; Name=1; Reviewed prediction
Add
BLAST
Topological domaini27 – 5125Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei52 – 7221Helical; Name=2; Reviewed prediction
Add
BLAST
Topological domaini73 – 9220Extracellular Reviewed prediction
Add
BLAST
Transmembranei93 – 11321Helical; Name=3; Reviewed prediction
Add
BLAST
Topological domaini114 – 13017Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei131 – 15121Helical; Name=4; Reviewed prediction
Add
BLAST
Topological domaini152 – 18736Extracellular Reviewed prediction
Add
BLAST
Transmembranei188 – 20821Helical; Name=5; Reviewed prediction
Add
BLAST
Topological domaini209 – 23224Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei233 – 24917Helical; Name=6; Reviewed prediction
Add
BLAST
Topological domaini250 – 26415Extracellular Reviewed prediction
Add
BLAST
Transmembranei265 – 28521Helical; Name=7; Reviewed prediction
Add
BLAST
Topological domaini286 – 31126Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 311311Vomeronasal type-1 receptor 3
PRO_0000070215Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi159 – 1591N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiQ9BXE9.

Expressioni

Gene expression databases

CleanExiHS_VN1R3.
GenevestigatoriQ9BXE9.

Structurei

3D structure databases

ProteinModelPortaliQ9BXE9.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG073430.
PhylomeDBiQ9BXE9.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR017452. GPCR_Rhodpsn_7TM.
IPR004072. Vmron_rcpt_1.
[Graphical view]
PfamiPF03402. V1R. 1 hit.
[Graphical view]
PRINTSiPR01534. VOMERONASL1R.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9BXE9-1 [UniParc]FASTAAdd to Basket

« Hide

MASKDFAIGM ILLSQIMVGF LGNFFLLYHY SFLCFTRGML QSTDLILKHL    50
TIANSLVILS KGIPQTMAAF GLKDSLSDIG CKFVFYVHRV GRAVCVGNAC 100
LLSVFQVITI SPSEFRWAEL KLHAHKYIRS FILVLCWILN TLVNITVLLH 150
VTGKWNSINS TKTNDYGYCS GGSRSRIPHS LHIVLLSSLD VLCLGLMTLA 200
SGSMVFILHR HKQQVQHIHG TNLSARSSPE SRVTQSILVL VSTLCYFTRS 250
PPSLHMSLFP NPSWWLLNTS ALITACFPMV SPFVLMSRHP RIPRLGSACC 300
GRNPQFPKLV R 311
Length:311
Mass (Da):34,713
Last modified:June 1, 2001 - v1
Checksum:iB310408A12160DBD
GO

Polymorphismi

There seems to be a deletion in the gene coding for this protein in about 98% of the population.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF336873 mRNA. Translation: AAK21299.1.
UniGeneiHs.257746.

Polymorphism databases

DMDMi68566227.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Protein Spotlight

No one nose - Issue 61 of August 2005

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF336873 mRNA. Translation: AAK21299.1 .
UniGenei Hs.257746.

3D structure databases

ProteinModelPortali Q9BXE9.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

GPCRDBi Search...

Polymorphism databases

DMDMi 68566227.

Proteomic databases

PRIDEi Q9BXE9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

GeneCardsi GC16M031818.
H-InvDB HIX0038719.
HGNCi HGNC:19867. VN1R3.
neXtProti NX_Q9BXE9.
GenAtlasi Search...

Phylogenomic databases

HOVERGENi HBG073430.
PhylomeDBi Q9BXE9.

Miscellaneous databases

PROi Q9BXE9.

Gene expression databases

CleanExi HS_VN1R3.
Genevestigatori Q9BXE9.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR017452. GPCR_Rhodpsn_7TM.
IPR004072. Vmron_rcpt_1.
[Graphical view ]
Pfami PF03402. V1R. 1 hit.
[Graphical view ]
PRINTSi PR01534. VOMERONASL1R.
PROSITEi PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cloning and characterization of FKSG46, a novel gene located on human chromosome 16."
    Wang Y.-G., Gong L.
    Submitted (JAN-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Novel human vomeronasal receptor-like genes reveal species-specific families."
    Rodriguez I., Mombaerts P.
    Curr. Biol. 12:R409-R411(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Evolutionary deterioration of the vomeronasal pheromone transduction pathway in catarrhine primates."
    Zhang J., Webb D.M.
    Proc. Natl. Acad. Sci. U.S.A. 100:8337-8341(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: DISCUSSION OF POLYMORPHISM.

Entry informationi

Entry nameiVN1R3_HUMAN
AccessioniPrimary (citable) accession number: Q9BXE9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: June 1, 2001
Last modified: April 16, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

The gorilla and orangutan orthologous proteins do not exist, their genes are pseudogenes.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  3. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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