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Q9BXD5

- NPL_HUMAN

UniProt

Q9BXD5 - NPL_HUMAN

Protein

N-acetylneuraminate lyase

Gene

NPL

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 106 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
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    Functioni

    Catalyzes the cleavage of N-acetylneuraminic acid (sialic acid) to form pyruvate and N-acetylmannosamine via a Schiff base intermediate. It prevents sialic acids from being recycled and returning to the cell surface. Involved in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway. Although human is not able to catalyze formation of Neu5Gc due to the inactive CMAHP enzyme, Neu5Gc is present in food and must be degraded By similarity.By similarity

    Catalytic activityi

    N-acetylneuraminate = N-acetyl-D-mannosamine + pyruvate.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei143 – 1431Involved in proton transfer during cleavageBy similarity
    Active sitei173 – 1731Schiff-base intermediate with substrateBy similarity

    GO - Molecular functioni

    1. N-acetylneuraminate lyase activity Source: UniProtKB

    GO - Biological processi

    1. carbohydrate metabolic process Source: UniProtKB-KW
    2. N-acetylneuraminate catabolic process Source: UniProtKB

    Keywords - Molecular functioni

    Lyase

    Keywords - Biological processi

    Carbohydrate metabolism

    Keywords - Ligandi

    Schiff base

    Enzyme and pathway databases

    ReactomeiREACT_200874. Sialic acid metabolism.
    UniPathwayiUPA00629.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    N-acetylneuraminate lyase (EC:4.1.3.3)
    Short name:
    NALase
    Alternative name(s):
    N-acetylneuraminate pyruvate-lyase
    N-acetylneuraminic acid aldolase
    Sialate lyase
    Sialate-pyruvate lyase
    Sialic acid aldolase
    Sialic acid lyase
    Gene namesi
    Name:NPL
    Synonyms:C1orf13
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:16781. NPL.

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA25602.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 320320N-acetylneuraminate lyasePRO_0000273352Add
    BLAST

    Proteomic databases

    MaxQBiQ9BXD5.
    PaxDbiQ9BXD5.
    PRIDEiQ9BXD5.

    PTM databases

    PhosphoSiteiQ9BXD5.

    Expressioni

    Tissue specificityi

    Isoform 2 is expressed in placenta, liver, kidney, pancreas, spleen, thymus, ovary, small intestine and peripheral blood leukocyte.1 Publication

    Gene expression databases

    ArrayExpressiQ9BXD5.
    BgeeiQ9BXD5.
    CleanExiHS_NPL.
    GenevestigatoriQ9BXD5.

    Organism-specific databases

    HPAiHPA028345.

    Interactioni

    Subunit structurei

    Homotetramer.By similarity

    Protein-protein interaction databases

    BioGridi123344. 1 interaction.
    STRINGi9606.ENSP00000258317.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9BXD5.
    SMRiQ9BXD5. Positions 8-280.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni51 – 522Substrate bindingBy similarity

    Sequence similaritiesi

    Belongs to the DapA family. NanA subfamily.Curated

    Phylogenomic databases

    eggNOGiCOG0329.
    HOGENOMiHOG000218206.
    HOVERGENiHBG082055.
    InParanoidiQ9BXD5.
    KOiK01639.
    OMAiVICRICF.
    OrthoDBiEOG7NKKKP.
    PhylomeDBiQ9BXD5.
    TreeFamiTF353639.

    Family and domain databases

    Gene3Di3.20.20.70. 1 hit.
    InterProiIPR013785. Aldolase_TIM.
    IPR002220. DapA-like.
    [Graphical view]
    PANTHERiPTHR12128. PTHR12128. 1 hit.
    PfamiPF00701. DHDPS. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001365. DHDPS. 1 hit.
    PRINTSiPR00146. DHPICSNTHASE.

    Sequences (5)i

    Sequence statusi: Complete.

    This entry describes 5 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9BXD5-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAFPKKKLQG LVAATITPMT ENGEINFSVI GQYVDYLVKE QGVKNIFVNG    50
    TTGEGLSLSV SERRQVAEEW VTKGKDKLDQ VIIHVGALSL KESQELAQHA 100
    AEIGADGIAV IAPFFLKPWT KDILINFLKE VAAAAPALPF YYYHIPALTG 150
    VKIRAEELLD GILDKIPTFQ GLKFSDTDLL DFGQCVDQNR QQQFAFLFGV 200
    DEQLLSALVM GATGAVGSTY NYLGKKTNQM LEAFEQKDFS LALNYQFCIQ 250
    RFINFVVKLG FGVSQTKAIM TLVSGIPMGP PRLPLQKASR EFTDSAEAKL 300
    KSLDFLSFTD LKDGNLEAGS 320
    Length:320
    Mass (Da):35,163
    Last modified:June 1, 2001 - v1
    Checksum:iFC0EBA9B05FE9E62
    GO
    Isoform 2 (identifier: Q9BXD5-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-77: MAFPKKKLQG...EEWVTKGKDK → MSRAPGILAS...LTVTRLWAER

    Show »
    Length:301
    Mass (Da):33,117
    Checksum:iD7168A22A2A7CD14
    GO
    Isoform 3 (identifier: Q9BXD5-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         260-320: GFGVSQTKAI...LKDGNLEAGS → ENSKLKVSKNQRTLPLGTTNFPFLH

    Note: No experimental confirmation available.

    Show »
    Length:284
    Mass (Da):31,562
    Checksum:i949BD9DA5FA2DB5C
    GO
    Isoform 4 (identifier: Q9BXD5-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         203-246: Missing.
         260-320: GFGVSQTKAI...LKDGNLEAGS → ENSKLKVSKNQRTLPLGTTNFPFLH

    Note: No experimental confirmation available.

    Show »
    Length:240
    Mass (Da):26,765
    Checksum:i2DAC394E4ACB1943
    GO
    Isoform 5 (identifier: Q9BXD5-5) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         78-109: LDQVIIHVGALSLKESQELAQHAAEIGADGIA → SNHHKLGTIRTTQSRQSSFRRQLKAWHSGSHL
         110-320: Missing.

    Note: No experimental confirmation available. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

    Show »
    Length:109
    Mass (Da):12,201
    Checksum:i3FEC87DFA591B0E1
    GO

    Sequence cautioni

    The sequence BC042003 differs from that shown. Reason: Frameshift at position 213.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti4 – 41P → S in BC034966. (PubMed:15489334)Curated
    Sequence conflicti98 – 981Q → E in BC042003. (PubMed:15489334)Curated
    Sequence conflicti212 – 2121A → E in BC042003. (PubMed:15489334)Curated
    Sequence conflicti260 – 2601G → V in BAG36036. (PubMed:14702039)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 7777MAFPK…KGKDK → MSRAPGILASWRRAPSLSVQ KGSQTARHTCHPEVPLGNCF LPVYKASPLTVTRLWAER in isoform 2. 1 PublicationVSP_022518Add
    BLAST
    Alternative sequencei78 – 10932LDQVI…ADGIA → SNHHKLGTIRTTQSRQSSFR RQLKAWHSGSHL in isoform 5. 1 PublicationVSP_022519Add
    BLAST
    Alternative sequencei110 – 320211Missing in isoform 5. 1 PublicationVSP_022520Add
    BLAST
    Alternative sequencei203 – 24644Missing in isoform 4. 1 PublicationVSP_022521Add
    BLAST
    Alternative sequencei260 – 32061GFGVS…LEAGS → ENSKLKVSKNQRTLPLGTTN FPFLH in isoform 3 and isoform 4. 1 PublicationVSP_022522Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF338436 mRNA. Translation: AAK25795.1.
    AY336748 mRNA. Translation: AAQ82432.1.
    AK313225 mRNA. Translation: BAG36036.1.
    AL355999, AL513344 Genomic DNA. Translation: CAH71702.1.
    AL355999, AL513344 Genomic DNA. Translation: CAH71703.1.
    AL513344, AL355999 Genomic DNA. Translation: CAI16502.1.
    AL513344, AL355999 Genomic DNA. Translation: CAI16503.1.
    BC034966 mRNA. No translation available.
    BC042003 mRNA. No translation available.
    BC058003 mRNA. Translation: AAH58003.1.
    BC125051 mRNA. Translation: AAI25052.1.
    CCDSiCCDS1350.1. [Q9BXD5-1]
    CCDS55666.1. [Q9BXD5-4]
    CCDS55667.1. [Q9BXD5-2]
    RefSeqiNP_001186979.1. NM_001200050.1. [Q9BXD5-2]
    NP_001186980.1. NM_001200051.1. [Q9BXD5-4]
    NP_001186985.1. NM_001200056.1. [Q9BXD5-3]
    NP_110396.1. NM_030769.2. [Q9BXD5-1]
    UniGeneiHs.496969.
    Hs.731792.

    Genome annotation databases

    EnsembliENST00000258317; ENSP00000258317; ENSG00000135838. [Q9BXD5-1]
    ENST00000367552; ENSP00000356523; ENSG00000135838. [Q9BXD5-4]
    ENST00000367553; ENSP00000356524; ENSG00000135838. [Q9BXD5-1]
    ENST00000367554; ENSP00000356525; ENSG00000135838. [Q9BXD5-2]
    ENST00000367555; ENSP00000356526; ENSG00000135838. [Q9BXD5-4]
    GeneIDi80896.
    KEGGihsa:80896.
    UCSCiuc001gpo.2. human. [Q9BXD5-2]
    uc001gpp.4. human. [Q9BXD5-3]
    uc009wyb.3. human. [Q9BXD5-1]
    uc009wyc.3. human. [Q9BXD5-4]

    Polymorphism databases

    DMDMi74752428.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF338436 mRNA. Translation: AAK25795.1 .
    AY336748 mRNA. Translation: AAQ82432.1 .
    AK313225 mRNA. Translation: BAG36036.1 .
    AL355999 , AL513344 Genomic DNA. Translation: CAH71702.1 .
    AL355999 , AL513344 Genomic DNA. Translation: CAH71703.1 .
    AL513344 , AL355999 Genomic DNA. Translation: CAI16502.1 .
    AL513344 , AL355999 Genomic DNA. Translation: CAI16503.1 .
    BC034966 mRNA. No translation available.
    BC042003 mRNA. No translation available.
    BC058003 mRNA. Translation: AAH58003.1 .
    BC125051 mRNA. Translation: AAI25052.1 .
    CCDSi CCDS1350.1. [Q9BXD5-1 ]
    CCDS55666.1. [Q9BXD5-4 ]
    CCDS55667.1. [Q9BXD5-2 ]
    RefSeqi NP_001186979.1. NM_001200050.1. [Q9BXD5-2 ]
    NP_001186980.1. NM_001200051.1. [Q9BXD5-4 ]
    NP_001186985.1. NM_001200056.1. [Q9BXD5-3 ]
    NP_110396.1. NM_030769.2. [Q9BXD5-1 ]
    UniGenei Hs.496969.
    Hs.731792.

    3D structure databases

    ProteinModelPortali Q9BXD5.
    SMRi Q9BXD5. Positions 8-280.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 123344. 1 interaction.
    STRINGi 9606.ENSP00000258317.

    PTM databases

    PhosphoSitei Q9BXD5.

    Polymorphism databases

    DMDMi 74752428.

    Proteomic databases

    MaxQBi Q9BXD5.
    PaxDbi Q9BXD5.
    PRIDEi Q9BXD5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000258317 ; ENSP00000258317 ; ENSG00000135838 . [Q9BXD5-1 ]
    ENST00000367552 ; ENSP00000356523 ; ENSG00000135838 . [Q9BXD5-4 ]
    ENST00000367553 ; ENSP00000356524 ; ENSG00000135838 . [Q9BXD5-1 ]
    ENST00000367554 ; ENSP00000356525 ; ENSG00000135838 . [Q9BXD5-2 ]
    ENST00000367555 ; ENSP00000356526 ; ENSG00000135838 . [Q9BXD5-4 ]
    GeneIDi 80896.
    KEGGi hsa:80896.
    UCSCi uc001gpo.2. human. [Q9BXD5-2 ]
    uc001gpp.4. human. [Q9BXD5-3 ]
    uc009wyb.3. human. [Q9BXD5-1 ]
    uc009wyc.3. human. [Q9BXD5-4 ]

    Organism-specific databases

    CTDi 80896.
    GeneCardsi GC01P182758.
    HGNCi HGNC:16781. NPL.
    HPAi HPA028345.
    MIMi 611412. gene.
    neXtProti NX_Q9BXD5.
    PharmGKBi PA25602.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0329.
    HOGENOMi HOG000218206.
    HOVERGENi HBG082055.
    InParanoidi Q9BXD5.
    KOi K01639.
    OMAi VICRICF.
    OrthoDBi EOG7NKKKP.
    PhylomeDBi Q9BXD5.
    TreeFami TF353639.

    Enzyme and pathway databases

    UniPathwayi UPA00629 .
    Reactomei REACT_200874. Sialic acid metabolism.

    Miscellaneous databases

    ChiTaRSi NPL. human.
    GenomeRNAii 80896.
    NextBioi 71336.
    PROi Q9BXD5.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9BXD5.
    Bgeei Q9BXD5.
    CleanExi HS_NPL.
    Genevestigatori Q9BXD5.

    Family and domain databases

    Gene3Di 3.20.20.70. 1 hit.
    InterProi IPR013785. Aldolase_TIM.
    IPR002220. DapA-like.
    [Graphical view ]
    PANTHERi PTHR12128. PTHR12128. 1 hit.
    Pfami PF00701. DHDPS. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001365. DHDPS. 1 hit.
    PRINTSi PR00146. DHPICSNTHASE.
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and characterization of 13 novel transcripts and the human RGS8 gene from the 1q25 region encompassing the hereditary prostate cancer (HPC1) locus."
      Sood R., Bonner T.I., Malakowska I., Stephan D.A., Robbins C.M., Connors T.D., Morgenbesser S.D., Su K., Faruque M.U., Pinkett H., Graham C., Baxevanis A.D., Klinger K.W., Landes G.M., Trent J.M., Carpten J.D.
      Genomics 73:211-222(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    2. "A novel splice variant of human gene NPL, mainly expressed in human liver, kidney and peripheral blood leukocyte."
      Wu M., Gu S., Xu J., Zou X., Zheng H., Jin Z., Xie Y., Ji C., Mao Y.
      DNA Seq. 16:137-142(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), TISSUE SPECIFICITY.
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Teratocarcinoma.
    4. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 3; 4 AND 5).
      Tissue: Hypothalamus, Kidney and Testis.
    6. "Metabolism of vertebrate amino sugars with N-glycolyl groups: elucidating the intracellular fate of the non-human sialic acid N-glycolylneuraminic acid."
      Bergfeld A.K., Pearce O.M., Diaz S.L., Pham T., Varki A.
      J. Biol. Chem. 287:28865-28881(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: PATHWAY.

    Entry informationi

    Entry nameiNPL_HUMAN
    AccessioniPrimary (citable) accession number: Q9BXD5
    Secondary accession number(s): B2R839
    , Q4G0Q8, Q4G0Z2, Q64L88, Q6PEL0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 23, 2007
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 106 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3