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Q9BXC1

- GP174_HUMAN

UniProt

Q9BXC1 - GP174_HUMAN

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Protein

Probable G-protein coupled receptor 174

Gene

GPR174

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Putative receptor for purines coupled to G-proteins.By similarity

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Probable G-protein coupled receptor 174
Gene namesi
Name:GPR174
ORF Names:FKSG79, GPCR17
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome X

Organism-specific databases

HGNCiHGNC:30245. GPR174.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134971573.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 333333Probable G-protein coupled receptor 174PRO_0000069654Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi4 – 41N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi91 ↔ 168PROSITE-ProRule annotation
Glycosylationi164 – 1641N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9BXC1.
PRIDEiQ9BXC1.

PTM databases

PhosphoSiteiQ9BXC1.

Expressioni

Gene expression databases

BgeeiQ9BXC1.
CleanExiHS_GPR174.
GenevestigatoriQ9BXC1.

Organism-specific databases

HPAiHPA041025.

Interactioni

Protein-protein interaction databases

IntActiQ9BXC1. 1 interaction.
STRINGi9606.ENSP00000276077.

Structurei

3D structure databases

ProteinModelPortaliQ9BXC1.
SMRiQ9BXC1. Positions 26-303.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2727ExtracellularSequence AnalysisAdd
BLAST
Topological domaini49 – 535CytoplasmicSequence Analysis
Topological domaini75 – 9117ExtracellularSequence AnalysisAdd
BLAST
Topological domaini113 – 13422CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini156 – 18227ExtracellularSequence AnalysisAdd
BLAST
Topological domaini204 – 23128CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini253 – 26917ExtracellularSequence AnalysisAdd
BLAST
Topological domaini291 – 33343CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei28 – 4821Helical; Name=1Sequence AnalysisAdd
BLAST
Transmembranei54 – 7421Helical; Name=2Sequence AnalysisAdd
BLAST
Transmembranei92 – 11221Helical; Name=3Sequence AnalysisAdd
BLAST
Transmembranei135 – 15521Helical; Name=4Sequence AnalysisAdd
BLAST
Transmembranei183 – 20321Helical; Name=5Sequence AnalysisAdd
BLAST
Transmembranei232 – 25221Helical; Name=6Sequence AnalysisAdd
BLAST
Transmembranei270 – 29021Helical; Name=7Sequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG147124.
GeneTreeiENSGT00760000118784.
HOGENOMiHOG000231258.
HOVERGENiHBG099867.
InParanoidiQ9BXC1.
KOiK08391.
OMAiYFTTDEF.
OrthoDBiEOG72JWGC.
PhylomeDBiQ9BXC1.
TreeFamiTF350009.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9BXC1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPANYTCTRP DGDNTDFRYF IYAVTYTVIL VPGLIGNILA LWVFYGYMKE
60 70 80 90 100
TKRAVIFMIN LAIADLLQVL SLPLRIFYYL NHDWPFGPGL CMFCFYLKYV
110 120 130 140 150
NMYASIYFLV CISVRRFWFL MYPFRFHDCK QKYDLYISIA GWLIICLACV
160 170 180 190 200
LFPLLRTSDD TSGNRTKCFV DLPTRNVNLA QSVVMMTIGE LIGFVTPLLI
210 220 230 240 250
VLYCTWKTVL SLQDKYPMAQ DLGEKQKALK MILTCAGVFL ICFAPYHFSF
260 270 280 290 300
PLDFLVKSNE IKSCLARRVI LIFHSVALCL ASLNSCLDPV IYYFSTNEFR
310 320 330
RRLSRQDLHD SIQLHAKSFV SNHTASTMTP ELC
Length:333
Mass (Da):38,503
Last modified:June 1, 2001 - v1
Checksum:i75043815CC7F69B4
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti162 – 1621S → P.
Corresponds to variant rs3827440 [ dbSNP | Ensembl ].
VAR_049409

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF345567 mRNA. Translation: AAK29070.1.
AB083599 Genomic DNA. Translation: BAB89312.1.
AY242133 Genomic DNA. Translation: AAO92300.1.
AL590222 Genomic DNA. Translation: CAD13458.1.
BC104922 mRNA. Translation: AAI04923.1.
BC104924 mRNA. Translation: AAI04925.1.
CCDSiCCDS14443.1.
RefSeqiNP_115942.1. NM_032553.1.
UniGeneiHs.326713.

Genome annotation databases

EnsembliENST00000276077; ENSP00000276077; ENSG00000147138.
GeneIDi84636.
KEGGihsa:84636.
UCSCiuc004edg.1. human.

Polymorphism databases

DMDMi21263618.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF345567 mRNA. Translation: AAK29070.1 .
AB083599 Genomic DNA. Translation: BAB89312.1 .
AY242133 Genomic DNA. Translation: AAO92300.1 .
AL590222 Genomic DNA. Translation: CAD13458.1 .
BC104922 mRNA. Translation: AAI04923.1 .
BC104924 mRNA. Translation: AAI04925.1 .
CCDSi CCDS14443.1.
RefSeqi NP_115942.1. NM_032553.1.
UniGenei Hs.326713.

3D structure databases

ProteinModelPortali Q9BXC1.
SMRi Q9BXC1. Positions 26-303.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q9BXC1. 1 interaction.
STRINGi 9606.ENSP00000276077.

Chemistry

GuidetoPHARMACOLOGYi 145.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei Q9BXC1.

Polymorphism databases

DMDMi 21263618.

Proteomic databases

PaxDbi Q9BXC1.
PRIDEi Q9BXC1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000276077 ; ENSP00000276077 ; ENSG00000147138 .
GeneIDi 84636.
KEGGi hsa:84636.
UCSCi uc004edg.1. human.

Organism-specific databases

CTDi 84636.
GeneCardsi GC0XP078426.
HGNCi HGNC:30245. GPR174.
HPAi HPA041025.
MIMi 300903. gene.
neXtProti NX_Q9BXC1.
PharmGKBi PA134971573.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG147124.
GeneTreei ENSGT00760000118784.
HOGENOMi HOG000231258.
HOVERGENi HBG099867.
InParanoidi Q9BXC1.
KOi K08391.
OMAi YFTTDEF.
OrthoDBi EOG72JWGC.
PhylomeDBi Q9BXC1.
TreeFami TF350009.

Miscellaneous databases

GeneWikii GPR174.
GenomeRNAii 84636.
NextBioi 74565.
PROi Q9BXC1.
SOURCEi Search...

Gene expression databases

Bgeei Q9BXC1.
CleanExi HS_GPR174.
Genevestigatori Q9BXC1.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view ]
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PROSITEi PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and characterization of FKSG79, a novel gene encoding a putative purinergic receptor."
    Wang Y.-G., Gong L.
    Submitted (FEB-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Identification of G protein-coupled receptor genes from the human genome sequence."
    Takeda S., Kadowaki S., Haga T., Takaesu H., Mitaku S.
    FEBS Lett. 520:97-101(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
    Warren C.N., Aronstam R.S., Sharma S.V.
    Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  4. "The DNA sequence of the human X chromosome."
    Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
    , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
    Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiGP174_HUMAN
AccessioniPrimary (citable) accession number: Q9BXC1
Secondary accession number(s): Q2M3F7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 27, 2002
Last sequence update: June 1, 2001
Last modified: October 29, 2014
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3