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Q9BXC1

- GP174_HUMAN

UniProt

Q9BXC1 - GP174_HUMAN

Protein

Probable G-protein coupled receptor 174

Gene

GPR174

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 110 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
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    Functioni

    Putative receptor for purines coupled to G-proteins.By similarity

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable G-protein coupled receptor 174
    Gene namesi
    Name:GPR174
    ORF Names:FKSG79, GPCR17
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome X

    Organism-specific databases

    HGNCiHGNC:30245. GPR174.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134971573.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 333333Probable G-protein coupled receptor 174PRO_0000069654Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi4 – 41N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi91 ↔ 168PROSITE-ProRule annotation
    Glycosylationi164 – 1641N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ9BXC1.
    PRIDEiQ9BXC1.

    PTM databases

    PhosphoSiteiQ9BXC1.

    Expressioni

    Gene expression databases

    BgeeiQ9BXC1.
    CleanExiHS_GPR174.
    GenevestigatoriQ9BXC1.

    Organism-specific databases

    HPAiHPA041025.

    Interactioni

    Protein-protein interaction databases

    IntActiQ9BXC1. 1 interaction.
    STRINGi9606.ENSP00000276077.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9BXC1.
    SMRiQ9BXC1. Positions 26-303.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2727ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini49 – 535CytoplasmicSequence Analysis
    Topological domaini75 – 9117ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini113 – 13422CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini156 – 18227ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini204 – 23128CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini253 – 26917ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini291 – 33343CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei28 – 4821Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei54 – 7421Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei92 – 11221Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei135 – 15521Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei183 – 20321Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei232 – 25221Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei270 – 29021Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG147124.
    HOGENOMiHOG000231258.
    HOVERGENiHBG099867.
    InParanoidiQ9BXC1.
    KOiK08391.
    OMAiYFTTDEF.
    OrthoDBiEOG72JWGC.
    PhylomeDBiQ9BXC1.
    TreeFamiTF350009.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view]
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9BXC1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPANYTCTRP DGDNTDFRYF IYAVTYTVIL VPGLIGNILA LWVFYGYMKE    50
    TKRAVIFMIN LAIADLLQVL SLPLRIFYYL NHDWPFGPGL CMFCFYLKYV 100
    NMYASIYFLV CISVRRFWFL MYPFRFHDCK QKYDLYISIA GWLIICLACV 150
    LFPLLRTSDD TSGNRTKCFV DLPTRNVNLA QSVVMMTIGE LIGFVTPLLI 200
    VLYCTWKTVL SLQDKYPMAQ DLGEKQKALK MILTCAGVFL ICFAPYHFSF 250
    PLDFLVKSNE IKSCLARRVI LIFHSVALCL ASLNSCLDPV IYYFSTNEFR 300
    RRLSRQDLHD SIQLHAKSFV SNHTASTMTP ELC 333
    Length:333
    Mass (Da):38,503
    Last modified:June 1, 2001 - v1
    Checksum:i75043815CC7F69B4
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti162 – 1621S → P.
    Corresponds to variant rs3827440 [ dbSNP | Ensembl ].
    VAR_049409

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF345567 mRNA. Translation: AAK29070.1.
    AB083599 Genomic DNA. Translation: BAB89312.1.
    AY242133 Genomic DNA. Translation: AAO92300.1.
    AL590222 Genomic DNA. Translation: CAD13458.1.
    BC104922 mRNA. Translation: AAI04923.1.
    BC104924 mRNA. Translation: AAI04925.1.
    CCDSiCCDS14443.1.
    RefSeqiNP_115942.1. NM_032553.1.
    UniGeneiHs.326713.

    Genome annotation databases

    EnsembliENST00000276077; ENSP00000276077; ENSG00000147138.
    GeneIDi84636.
    KEGGihsa:84636.
    UCSCiuc004edg.1. human.

    Polymorphism databases

    DMDMi21263618.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF345567 mRNA. Translation: AAK29070.1 .
    AB083599 Genomic DNA. Translation: BAB89312.1 .
    AY242133 Genomic DNA. Translation: AAO92300.1 .
    AL590222 Genomic DNA. Translation: CAD13458.1 .
    BC104922 mRNA. Translation: AAI04923.1 .
    BC104924 mRNA. Translation: AAI04925.1 .
    CCDSi CCDS14443.1.
    RefSeqi NP_115942.1. NM_032553.1.
    UniGenei Hs.326713.

    3D structure databases

    ProteinModelPortali Q9BXC1.
    SMRi Q9BXC1. Positions 26-303.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q9BXC1. 1 interaction.
    STRINGi 9606.ENSP00000276077.

    Chemistry

    GuidetoPHARMACOLOGYi 145.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei Q9BXC1.

    Polymorphism databases

    DMDMi 21263618.

    Proteomic databases

    PaxDbi Q9BXC1.
    PRIDEi Q9BXC1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000276077 ; ENSP00000276077 ; ENSG00000147138 .
    GeneIDi 84636.
    KEGGi hsa:84636.
    UCSCi uc004edg.1. human.

    Organism-specific databases

    CTDi 84636.
    GeneCardsi GC0XP078426.
    HGNCi HGNC:30245. GPR174.
    HPAi HPA041025.
    MIMi 300903. gene.
    neXtProti NX_Q9BXC1.
    PharmGKBi PA134971573.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG147124.
    HOGENOMi HOG000231258.
    HOVERGENi HBG099867.
    InParanoidi Q9BXC1.
    KOi K08391.
    OMAi YFTTDEF.
    OrthoDBi EOG72JWGC.
    PhylomeDBi Q9BXC1.
    TreeFami TF350009.

    Miscellaneous databases

    GeneWikii GPR174.
    GenomeRNAii 84636.
    NextBioi 74565.
    PROi Q9BXC1.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9BXC1.
    CleanExi HS_GPR174.
    Genevestigatori Q9BXC1.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view ]
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PROSITEi PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and characterization of FKSG79, a novel gene encoding a putative purinergic receptor."
      Wang Y.-G., Gong L.
      Submitted (FEB-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Identification of G protein-coupled receptor genes from the human genome sequence."
      Takeda S., Kadowaki S., Haga T., Takaesu H., Mitaku S.
      FEBS Lett. 520:97-101(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
      Warren C.N., Aronstam R.S., Sharma S.V.
      Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    4. "The DNA sequence of the human X chromosome."
      Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
      , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
      Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.

    Entry informationi

    Entry nameiGP174_HUMAN
    AccessioniPrimary (citable) accession number: Q9BXC1
    Secondary accession number(s): Q2M3F7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 27, 2002
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 110 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome X
      Human chromosome X: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3