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Protein

Probable G-protein coupled receptor 174

Gene

GPR174

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Putative receptor for purines coupled to G-proteins.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

BioCyciZFISH:ENSG00000147138-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable G-protein coupled receptor 174
Gene namesi
Name:GPR174
ORF Names:FKSG79, GPCR17
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:30245. GPR174.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 27ExtracellularSequence analysisAdd BLAST27
Transmembranei28 – 48Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini49 – 53CytoplasmicSequence analysis5
Transmembranei54 – 74Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini75 – 91ExtracellularSequence analysisAdd BLAST17
Transmembranei92 – 112Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini113 – 134CytoplasmicSequence analysisAdd BLAST22
Transmembranei135 – 155Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini156 – 182ExtracellularSequence analysisAdd BLAST27
Transmembranei183 – 203Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini204 – 231CytoplasmicSequence analysisAdd BLAST28
Transmembranei232 – 252Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini253 – 269ExtracellularSequence analysisAdd BLAST17
Transmembranei270 – 290Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini291 – 333CytoplasmicSequence analysisAdd BLAST43

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi84636.
OpenTargetsiENSG00000147138.
PharmGKBiPA134971573.

Chemistry databases

ChEMBLiCHEMBL3562167.
GuidetoPHARMACOLOGYi145.

Polymorphism and mutation databases

BioMutaiGPR174.
DMDMi21263618.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000696541 – 333Probable G-protein coupled receptor 174Add BLAST333

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi4N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi91 ↔ 168PROSITE-ProRule annotation
Glycosylationi164N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9BXC1.
PeptideAtlasiQ9BXC1.
PRIDEiQ9BXC1.

PTM databases

iPTMnetiQ9BXC1.
PhosphoSitePlusiQ9BXC1.

Expressioni

Gene expression databases

BgeeiENSG00000147138.
CleanExiHS_GPR174.
GenevisibleiQ9BXC1. HS.

Organism-specific databases

HPAiHPA041025.

Interactioni

Protein-protein interaction databases

IntActiQ9BXC1. 1 interactor.
STRINGi9606.ENSP00000276077.

Structurei

3D structure databases

ProteinModelPortaliQ9BXC1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IH6K. Eukaryota.
ENOG410ZJNT. LUCA.
GeneTreeiENSGT00760000118784.
HOGENOMiHOG000231258.
HOVERGENiHBG099867.
InParanoidiQ9BXC1.
KOiK08391.
OMAiFTTDEFR.
OrthoDBiEOG091G0DAI.
PhylomeDBiQ9BXC1.
TreeFamiTF350009.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9BXC1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPANYTCTRP DGDNTDFRYF IYAVTYTVIL VPGLIGNILA LWVFYGYMKE
60 70 80 90 100
TKRAVIFMIN LAIADLLQVL SLPLRIFYYL NHDWPFGPGL CMFCFYLKYV
110 120 130 140 150
NMYASIYFLV CISVRRFWFL MYPFRFHDCK QKYDLYISIA GWLIICLACV
160 170 180 190 200
LFPLLRTSDD TSGNRTKCFV DLPTRNVNLA QSVVMMTIGE LIGFVTPLLI
210 220 230 240 250
VLYCTWKTVL SLQDKYPMAQ DLGEKQKALK MILTCAGVFL ICFAPYHFSF
260 270 280 290 300
PLDFLVKSNE IKSCLARRVI LIFHSVALCL ASLNSCLDPV IYYFSTNEFR
310 320 330
RRLSRQDLHD SIQLHAKSFV SNHTASTMTP ELC
Length:333
Mass (Da):38,503
Last modified:June 1, 2001 - v1
Checksum:i75043815CC7F69B4
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_049409162S → P.Corresponds to variant rs3827440dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF345567 mRNA. Translation: AAK29070.1.
AB083599 Genomic DNA. Translation: BAB89312.1.
AY242133 Genomic DNA. Translation: AAO92300.1.
AL590222 Genomic DNA. Translation: CAD13458.1.
BC104922 mRNA. Translation: AAI04923.1.
BC104924 mRNA. Translation: AAI04925.1.
CCDSiCCDS14443.1.
RefSeqiNP_115942.1. NM_032553.1.
UniGeneiHs.326713.

Genome annotation databases

EnsembliENST00000276077; ENSP00000276077; ENSG00000147138.
GeneIDi84636.
KEGGihsa:84636.
UCSCiuc004edg.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF345567 mRNA. Translation: AAK29070.1.
AB083599 Genomic DNA. Translation: BAB89312.1.
AY242133 Genomic DNA. Translation: AAO92300.1.
AL590222 Genomic DNA. Translation: CAD13458.1.
BC104922 mRNA. Translation: AAI04923.1.
BC104924 mRNA. Translation: AAI04925.1.
CCDSiCCDS14443.1.
RefSeqiNP_115942.1. NM_032553.1.
UniGeneiHs.326713.

3D structure databases

ProteinModelPortaliQ9BXC1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9BXC1. 1 interactor.
STRINGi9606.ENSP00000276077.

Chemistry databases

ChEMBLiCHEMBL3562167.
GuidetoPHARMACOLOGYi145.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ9BXC1.
PhosphoSitePlusiQ9BXC1.

Polymorphism and mutation databases

BioMutaiGPR174.
DMDMi21263618.

Proteomic databases

PaxDbiQ9BXC1.
PeptideAtlasiQ9BXC1.
PRIDEiQ9BXC1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000276077; ENSP00000276077; ENSG00000147138.
GeneIDi84636.
KEGGihsa:84636.
UCSCiuc004edg.1. human.

Organism-specific databases

CTDi84636.
DisGeNETi84636.
GeneCardsiGPR174.
HGNCiHGNC:30245. GPR174.
HPAiHPA041025.
MIMi300903. gene.
neXtProtiNX_Q9BXC1.
OpenTargetsiENSG00000147138.
PharmGKBiPA134971573.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IH6K. Eukaryota.
ENOG410ZJNT. LUCA.
GeneTreeiENSGT00760000118784.
HOGENOMiHOG000231258.
HOVERGENiHBG099867.
InParanoidiQ9BXC1.
KOiK08391.
OMAiFTTDEFR.
OrthoDBiEOG091G0DAI.
PhylomeDBiQ9BXC1.
TreeFamiTF350009.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000147138-MONOMER.

Miscellaneous databases

GeneWikiiGPR174.
GenomeRNAii84636.
PROiQ9BXC1.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000147138.
CleanExiHS_GPR174.
GenevisibleiQ9BXC1. HS.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGP174_HUMAN
AccessioniPrimary (citable) accession number: Q9BXC1
Secondary accession number(s): Q2M3F7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 27, 2002
Last sequence update: June 1, 2001
Last modified: November 30, 2016
This is version 124 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.