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Protein

Probable G-protein coupled receptor 174

Gene

GPR174

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Putative receptor for purines coupled to G-proteins.By similarity

GO - Molecular functioni

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Probable G-protein coupled receptor 174
Gene namesi
Name:GPR174
ORF Names:FKSG79, GPCR17
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000147138.1
HGNCiHGNC:30245 GPR174
MIMi300903 gene
neXtProtiNX_Q9BXC1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 27ExtracellularSequence analysisAdd BLAST27
Transmembranei28 – 48Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini49 – 53CytoplasmicSequence analysis5
Transmembranei54 – 74Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini75 – 91ExtracellularSequence analysisAdd BLAST17
Transmembranei92 – 112Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini113 – 134CytoplasmicSequence analysisAdd BLAST22
Transmembranei135 – 155Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini156 – 182ExtracellularSequence analysisAdd BLAST27
Transmembranei183 – 203Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini204 – 231CytoplasmicSequence analysisAdd BLAST28
Transmembranei232 – 252Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini253 – 269ExtracellularSequence analysisAdd BLAST17
Transmembranei270 – 290Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini291 – 333CytoplasmicSequence analysisAdd BLAST43

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi84636
OpenTargetsiENSG00000147138
PharmGKBiPA134971573

Chemistry databases

ChEMBLiCHEMBL3562167
GuidetoPHARMACOLOGYi145

Polymorphism and mutation databases

BioMutaiGPR174
DMDMi21263618

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000696541 – 333Probable G-protein coupled receptor 174Add BLAST333

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi4N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi91 ↔ 168PROSITE-ProRule annotation
Glycosylationi164N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9BXC1
PeptideAtlasiQ9BXC1
PRIDEiQ9BXC1

PTM databases

iPTMnetiQ9BXC1
PhosphoSitePlusiQ9BXC1

Expressioni

Gene expression databases

BgeeiENSG00000147138
CleanExiHS_GPR174
GenevisibleiQ9BXC1 HS

Organism-specific databases

HPAiHPA041025

Interactioni

Protein-protein interaction databases

IntActiQ9BXC1, 1 interactor

Chemistry databases

BindingDBiQ9BXC1

Structurei

3D structure databases

ProteinModelPortaliQ9BXC1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IH6K Eukaryota
ENOG410ZJNT LUCA
GeneTreeiENSGT00910000143980
HOGENOMiHOG000231258
HOVERGENiHBG099867
InParanoidiQ9BXC1
KOiK08391
OMAiLYCSWKT
OrthoDBiEOG091G0DAI
PhylomeDBiQ9BXC1
TreeFamiTF350009

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PROSITEiView protein in PROSITE
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q9BXC1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPANYTCTRP DGDNTDFRYF IYAVTYTVIL VPGLIGNILA LWVFYGYMKE
60 70 80 90 100
TKRAVIFMIN LAIADLLQVL SLPLRIFYYL NHDWPFGPGL CMFCFYLKYV
110 120 130 140 150
NMYASIYFLV CISVRRFWFL MYPFRFHDCK QKYDLYISIA GWLIICLACV
160 170 180 190 200
LFPLLRTSDD TSGNRTKCFV DLPTRNVNLA QSVVMMTIGE LIGFVTPLLI
210 220 230 240 250
VLYCTWKTVL SLQDKYPMAQ DLGEKQKALK MILTCAGVFL ICFAPYHFSF
260 270 280 290 300
PLDFLVKSNE IKSCLARRVI LIFHSVALCL ASLNSCLDPV IYYFSTNEFR
310 320 330
RRLSRQDLHD SIQLHAKSFV SNHTASTMTP ELC
Length:333
Mass (Da):38,503
Last modified:June 1, 2001 - v1
Checksum:i75043815CC7F69B4
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_049409162S → P. Corresponds to variant dbSNP:rs3827440Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF345567 mRNA Translation: AAK29070.1
AB083599 Genomic DNA Translation: BAB89312.1
AY242133 Genomic DNA Translation: AAO92300.1
AL590222 Genomic DNA No translation available.
BC104922 mRNA Translation: AAI04923.1
BC104924 mRNA Translation: AAI04925.1
CCDSiCCDS14443.1
RefSeqiNP_115942.1, NM_032553.1
UniGeneiHs.326713

Genome annotation databases

EnsembliENST00000276077; ENSP00000276077; ENSG00000147138
GeneIDi84636
KEGGihsa:84636
UCSCiuc004edg.1 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiGP174_HUMAN
AccessioniPrimary (citable) accession number: Q9BXC1
Secondary accession number(s): Q2M3F7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 27, 2002
Last sequence update: June 1, 2001
Last modified: April 25, 2018
This is version 134 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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