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Protein

Hydroxycarboxylic acid receptor 1

Gene

HCAR1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Acts as a receptor for L-lactate and mediates its anti-lipolytic effect through a G(i)-protein-mediated pathway.1 Publication

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

BioCyciZFISH:G66-33556-MONOMER.
ReactomeiR-HSA-3296197. Hydroxycarboxylic acid-binding receptors.
R-HSA-418594. G alpha (i) signalling events.

Protein family/group databases

TCDBi9.A.14.13.4. the g-protein-coupled receptor (gpcr) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Hydroxycarboxylic acid receptor 1
Alternative name(s):
G-protein coupled receptor 104
G-protein coupled receptor 81
Gene namesi
Name:HCAR1
Synonyms:GPR104, GPR81, HCA1
ORF Names:FKSG80
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:4532. HCAR1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 21ExtracellularSequence analysisAdd BLAST21
Transmembranei22 – 42Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini43 – 49CytoplasmicSequence analysis7
Transmembranei50 – 70Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini71 – 89ExtracellularSequence analysisAdd BLAST19
Transmembranei90 – 110Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini111 – 130CytoplasmicSequence analysisAdd BLAST20
Transmembranei131 – 151Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini152 – 182ExtracellularSequence analysisAdd BLAST31
Transmembranei183 – 203Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini204 – 220CytoplasmicSequence analysisAdd BLAST17
Transmembranei221 – 241Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini242 – 261ExtracellularSequence analysisAdd BLAST20
Transmembranei262 – 281Helical; Name=7Sequence analysisAdd BLAST20
Topological domaini282 – 346CytoplasmicSequence analysisAdd BLAST65

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi99R → A: Diminishes the response to L-lactate. 1 Publication1
Mutagenesisi233Y → A: Diminishes the response to L-lactate. 1 Publication1
Mutagenesisi240R → A: Diminishes the response to L-lactate. 1 Publication1
Mutagenesisi267T → A: Diminishes the response to L-lactate. 1 Publication1

Organism-specific databases

DisGeNETi27198.
OpenTargetsiENSG00000196917.
PharmGKBiPA28925.

Chemistry databases

ChEMBLiCHEMBL1075101.
GuidetoPHARMACOLOGYi311.

Polymorphism and mutation databases

BioMutaiHCAR1.
DMDMi47117701.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000695861 – 346Hydroxycarboxylic acid receptor 1Add BLAST346

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi3N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi88 ↔ 165PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9BXC0.
PeptideAtlasiQ9BXC0.
PRIDEiQ9BXC0.

PTM databases

PhosphoSitePlusiQ9BXC0.

Expressioni

Tissue specificityi

Expressed abundantly in brown and white fat. It also detectable at lower levels in liver, kidney, skeletal muscle, brain and pituitary. Not detected in frontal, temporal and occipital lobes of the cortex, basal forebrain, caudate nucleus, nucleus accumbens and hippocampus.2 Publications

Gene expression databases

BgeeiENSG00000196917.
CleanExiHS_GPR81.
GenevisibleiQ9BXC0. HS.

Interactioni

Protein-protein interaction databases

BioGridi118073. 2 interactors.
IntActiQ9BXC0. 1 interactor.
STRINGi9606.ENSP00000349478.

Chemistry databases

BindingDBiQ9BXC0.

Structurei

3D structure databases

ProteinModelPortaliQ9BXC0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IKI5. Eukaryota.
ENOG4110VUM. LUCA.
GeneTreeiENSGT00510000046798.
HOVERGENiHBG051680.
InParanoidiQ9BXC0.
KOiK08401.
OMAiMFQLEFF.
OrthoDBiEOG091G0AN6.
PhylomeDBiQ9BXC0.
TreeFamiTF330775.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR028016. HCAR1_rcpt.
[Graphical view]
PANTHERiPTHR24231:SF29. PTHR24231:SF29. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9BXC0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYNGSCCRIE GDTISQVMPP LLIVAFVLGA LGNGVALCGF CFHMKTWKPS
60 70 80 90 100
TVYLFNLAVA DFLLMICLPF RTDYYLRRRH WAFGDIPCRV GLFTLAMNRA
110 120 130 140 150
GSIVFLTVVA ADRYFKVVHP HHAVNTISTR VAAGIVCTLW ALVILGTVYL
160 170 180 190 200
LLENHLCVQE TAVSCESFIM ESANGWHDIM FQLEFFMPLG IILFCSFKIV
210 220 230 240 250
WSLRRRQQLA RQARMKKATR FIMVVAIVFI TCYLPSVSAR LYFLWTVPSS
260 270 280 290 300
ACDPSVHGAL HITLSFTYMN SMLDPLVYYF SSPSFPKFYN KLKICSLKPK
310 320 330 340
QPGHSKTQRP EEMPISNLGR RSCISVANSF QSQSDGQWDP HIVEWH
Length:346
Mass (Da):39,295
Last modified:June 1, 2001 - v1
Checksum:iE0DB114EEB3A47A5
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti38C → Y in AAH95506 (PubMed:15489334).Curated1
Sequence conflicti113R → K in AAH66883 (PubMed:15489334).Curated1
Sequence conflicti187M → I in AAH95506 (PubMed:15489334).Curated1
Sequence conflicti213A → T in AAH95506 (PubMed:15489334).Curated1
Sequence conflicti222I → T in AAH95506 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02515143H → Q.1 PublicationCorresponds to variant rs35292336dbSNPEnsembl.1
Natural variantiVAR_025152253D → E.1 Publication1
Natural variantiVAR_061218253D → H.Corresponds to variant rs36124671dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF411110 Genomic DNA. Translation: AAL26481.1.
EU809458 mRNA. Translation: ACJ03844.1.
AF345568 mRNA. Translation: AAK29071.1.
AB065866 Genomic DNA. Translation: BAC06084.1.
AY507143 mRNA. Translation: AAR92485.1.
AK313955 mRNA. Translation: BAG36671.1.
AB083631 Genomic DNA. Translation: BAB89344.1.
DQ157221 Genomic DNA. Translation: AAZ67915.1.
AC026333 Genomic DNA. No translation available.
CH471054 Genomic DNA. Translation: EAW98337.1.
BC066881 mRNA. Translation: AAH66881.1.
BC066882 mRNA. Translation: AAH66882.1.
BC066883 mRNA. Translation: AAH66883.1.
BC067484 mRNA. Translation: AAH67484.1.
BC095506 mRNA. Translation: AAH95506.1.
CCDSiCCDS9236.1.
RefSeqiNP_115943.1. NM_032554.3.
UniGeneiHs.610873.
Hs.711001.

Genome annotation databases

EnsembliENST00000432564; ENSP00000389255; ENSG00000196917.
GeneIDi27198.
KEGGihsa:27198.
UCSCiuc001ucz.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

SeattleSNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF411110 Genomic DNA. Translation: AAL26481.1.
EU809458 mRNA. Translation: ACJ03844.1.
AF345568 mRNA. Translation: AAK29071.1.
AB065866 Genomic DNA. Translation: BAC06084.1.
AY507143 mRNA. Translation: AAR92485.1.
AK313955 mRNA. Translation: BAG36671.1.
AB083631 Genomic DNA. Translation: BAB89344.1.
DQ157221 Genomic DNA. Translation: AAZ67915.1.
AC026333 Genomic DNA. No translation available.
CH471054 Genomic DNA. Translation: EAW98337.1.
BC066881 mRNA. Translation: AAH66881.1.
BC066882 mRNA. Translation: AAH66882.1.
BC066883 mRNA. Translation: AAH66883.1.
BC067484 mRNA. Translation: AAH67484.1.
BC095506 mRNA. Translation: AAH95506.1.
CCDSiCCDS9236.1.
RefSeqiNP_115943.1. NM_032554.3.
UniGeneiHs.610873.
Hs.711001.

3D structure databases

ProteinModelPortaliQ9BXC0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi118073. 2 interactors.
IntActiQ9BXC0. 1 interactor.
STRINGi9606.ENSP00000349478.

Chemistry databases

BindingDBiQ9BXC0.
ChEMBLiCHEMBL1075101.
GuidetoPHARMACOLOGYi311.

Protein family/group databases

TCDBi9.A.14.13.4. the g-protein-coupled receptor (gpcr) family.
GPCRDBiSearch...

PTM databases

PhosphoSitePlusiQ9BXC0.

Polymorphism and mutation databases

BioMutaiHCAR1.
DMDMi47117701.

Proteomic databases

PaxDbiQ9BXC0.
PeptideAtlasiQ9BXC0.
PRIDEiQ9BXC0.

Protocols and materials databases

DNASUi27198.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000432564; ENSP00000389255; ENSG00000196917.
GeneIDi27198.
KEGGihsa:27198.
UCSCiuc001ucz.4. human.

Organism-specific databases

CTDi27198.
DisGeNETi27198.
GeneCardsiHCAR1.
H-InvDBHIX0026348.
HGNCiHGNC:4532. HCAR1.
MIMi606923. gene.
neXtProtiNX_Q9BXC0.
OpenTargetsiENSG00000196917.
PharmGKBiPA28925.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IKI5. Eukaryota.
ENOG4110VUM. LUCA.
GeneTreeiENSGT00510000046798.
HOVERGENiHBG051680.
InParanoidiQ9BXC0.
KOiK08401.
OMAiMFQLEFF.
OrthoDBiEOG091G0AN6.
PhylomeDBiQ9BXC0.
TreeFamiTF330775.

Enzyme and pathway databases

BioCyciZFISH:G66-33556-MONOMER.
ReactomeiR-HSA-3296197. Hydroxycarboxylic acid-binding receptors.
R-HSA-418594. G alpha (i) signalling events.

Miscellaneous databases

GeneWikiiGPR81.
GenomeRNAii27198.
PROiQ9BXC0.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000196917.
CleanExiHS_GPR81.
GenevisibleiQ9BXC0. HS.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR028016. HCAR1_rcpt.
[Graphical view]
PANTHERiPTHR24231:SF29. PTHR24231:SF29. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHCAR1_HUMAN
AccessioniPrimary (citable) accession number: Q9BXC0
Secondary accession number(s): B2R9X4
, Q3Y5J3, Q4VBN1, Q6NXU5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: June 1, 2001
Last modified: November 2, 2016
This is version 134 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.