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Q9BXC0

- HCAR1_HUMAN

UniProt

Q9BXC0 - HCAR1_HUMAN

Protein

Hydroxycarboxylic acid receptor 1

Gene

HCAR1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 116 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
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    Functioni

    Acts as a receptor for L-lactate and mediates its anti-lipolytic effect through a G(i)-protein-mediated pathway.1 Publication

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: UniProtKB-KW

    GO - Biological processi

    1. response to estradiol Source: BHF-UCL

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Enzyme and pathway databases

    ReactomeiREACT_163785. Hydroxycarboxylic acid-binding receptors.
    REACT_19231. G alpha (i) signalling events.

    Protein family/group databases

    TCDBi9.A.14.13.4. the g-protein-coupled receptor (gpcr) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Hydroxycarboxylic acid receptor 1
    Alternative name(s):
    G-protein coupled receptor 104
    G-protein coupled receptor 81
    Gene namesi
    Name:HCAR1
    Synonyms:GPR104, GPR81, HCA1
    ORF Names:FKSG80
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 12

    Organism-specific databases

    HGNCiHGNC:4532. HCAR1.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi99 – 991R → A: Diminishes the response to L-lactate. 1 Publication
    Mutagenesisi233 – 2331Y → A: Diminishes the response to L-lactate. 1 Publication
    Mutagenesisi240 – 2401R → A: Diminishes the response to L-lactate. 1 Publication
    Mutagenesisi267 – 2671T → A: Diminishes the response to L-lactate. 1 Publication

    Organism-specific databases

    PharmGKBiPA28925.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 346346Hydroxycarboxylic acid receptor 1PRO_0000069586Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi3 – 31N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi88 ↔ 165PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ9BXC0.
    PRIDEiQ9BXC0.

    PTM databases

    PhosphoSiteiQ9BXC0.

    Expressioni

    Tissue specificityi

    Expressed abundantly in brown and white fat. It also detectable at lower levels in liver, kidney, skeletal muscle, brain and pituitary. Not detected in frontal, temporal and occipital lobes of the cortex, basal forebrain, caudate nucleus, nucleus accumbens and hippocampus.2 Publications

    Gene expression databases

    BgeeiQ9BXC0.
    CleanExiHS_GPR81.
    GenevestigatoriQ9BXC0.

    Interactioni

    Protein-protein interaction databases

    IntActiQ9BXC0. 1 interaction.
    STRINGi9606.ENSP00000349478.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9BXC0.
    SMRiQ9BXC0. Positions 18-285.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2121ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini43 – 497CytoplasmicSequence Analysis
    Topological domaini71 – 8919ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini111 – 13020CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini152 – 18231ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini204 – 22017CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini242 – 26120ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini282 – 34665CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei22 – 4221Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei50 – 7021Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei90 – 11021Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei131 – 15121Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei183 – 20321Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei221 – 24121Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei262 – 28120Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG148165.
    HOVERGENiHBG051680.
    InParanoidiQ9BXC0.
    KOiK08401.
    OMAiLAMNRAG.
    OrthoDBiEOG7R56SR.
    PhylomeDBiQ9BXC0.
    TreeFamiTF330775.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR028016. HCAR1_rcpt.
    [Graphical view]
    PANTHERiPTHR24231:SF29. PTHR24231:SF29. 1 hit.
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9BXC0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MYNGSCCRIE GDTISQVMPP LLIVAFVLGA LGNGVALCGF CFHMKTWKPS    50
    TVYLFNLAVA DFLLMICLPF RTDYYLRRRH WAFGDIPCRV GLFTLAMNRA 100
    GSIVFLTVVA ADRYFKVVHP HHAVNTISTR VAAGIVCTLW ALVILGTVYL 150
    LLENHLCVQE TAVSCESFIM ESANGWHDIM FQLEFFMPLG IILFCSFKIV 200
    WSLRRRQQLA RQARMKKATR FIMVVAIVFI TCYLPSVSAR LYFLWTVPSS 250
    ACDPSVHGAL HITLSFTYMN SMLDPLVYYF SSPSFPKFYN KLKICSLKPK 300
    QPGHSKTQRP EEMPISNLGR RSCISVANSF QSQSDGQWDP HIVEWH 346
    Length:346
    Mass (Da):39,295
    Last modified:June 1, 2001 - v1
    Checksum:iE0DB114EEB3A47A5
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti38 – 381C → Y in AAH95506. (PubMed:15489334)Curated
    Sequence conflicti113 – 1131R → K in AAH66883. (PubMed:15489334)Curated
    Sequence conflicti187 – 1871M → I in AAH95506. (PubMed:15489334)Curated
    Sequence conflicti213 – 2131A → T in AAH95506. (PubMed:15489334)Curated
    Sequence conflicti222 – 2221I → T in AAH95506. (PubMed:15489334)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti43 – 431H → Q.1 Publication
    Corresponds to variant rs35292336 [ dbSNP | Ensembl ].
    VAR_025151
    Natural varianti253 – 2531D → E.1 Publication
    VAR_025152
    Natural varianti253 – 2531D → H.
    Corresponds to variant rs36124671 [ dbSNP | Ensembl ].
    VAR_061218

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF411110 Genomic DNA. Translation: AAL26481.1.
    EU809458 mRNA. Translation: ACJ03844.1.
    AF345568 mRNA. Translation: AAK29071.1.
    AB065866 Genomic DNA. Translation: BAC06084.1.
    AY507143 mRNA. Translation: AAR92485.1.
    AK313955 mRNA. Translation: BAG36671.1.
    AB083631 Genomic DNA. Translation: BAB89344.1.
    DQ157221 Genomic DNA. Translation: AAZ67915.1.
    AC026333 Genomic DNA. No translation available.
    CH471054 Genomic DNA. Translation: EAW98337.1.
    BC066881 mRNA. Translation: AAH66881.1.
    BC066882 mRNA. Translation: AAH66882.1.
    BC066883 mRNA. Translation: AAH66883.1.
    BC067484 mRNA. Translation: AAH67484.1.
    BC095506 mRNA. Translation: AAH95506.1.
    CCDSiCCDS9236.1.
    RefSeqiNP_115943.1. NM_032554.3.
    UniGeneiHs.610873.
    Hs.711001.

    Genome annotation databases

    EnsembliENST00000432564; ENSP00000389255; ENSG00000196917.
    GeneIDi27198.
    KEGGihsa:27198.
    UCSCiuc001ucz.3. human.

    Polymorphism databases

    DMDMi47117701.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    SeattleSNPs

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF411110 Genomic DNA. Translation: AAL26481.1 .
    EU809458 mRNA. Translation: ACJ03844.1 .
    AF345568 mRNA. Translation: AAK29071.1 .
    AB065866 Genomic DNA. Translation: BAC06084.1 .
    AY507143 mRNA. Translation: AAR92485.1 .
    AK313955 mRNA. Translation: BAG36671.1 .
    AB083631 Genomic DNA. Translation: BAB89344.1 .
    DQ157221 Genomic DNA. Translation: AAZ67915.1 .
    AC026333 Genomic DNA. No translation available.
    CH471054 Genomic DNA. Translation: EAW98337.1 .
    BC066881 mRNA. Translation: AAH66881.1 .
    BC066882 mRNA. Translation: AAH66882.1 .
    BC066883 mRNA. Translation: AAH66883.1 .
    BC067484 mRNA. Translation: AAH67484.1 .
    BC095506 mRNA. Translation: AAH95506.1 .
    CCDSi CCDS9236.1.
    RefSeqi NP_115943.1. NM_032554.3.
    UniGenei Hs.610873.
    Hs.711001.

    3D structure databases

    ProteinModelPortali Q9BXC0.
    SMRi Q9BXC0. Positions 18-285.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q9BXC0. 1 interaction.
    STRINGi 9606.ENSP00000349478.

    Chemistry

    ChEMBLi CHEMBL1075101.
    GuidetoPHARMACOLOGYi 311.

    Protein family/group databases

    TCDBi 9.A.14.13.4. the g-protein-coupled receptor (gpcr) family.
    GPCRDBi Search...

    PTM databases

    PhosphoSitei Q9BXC0.

    Polymorphism databases

    DMDMi 47117701.

    Proteomic databases

    PaxDbi Q9BXC0.
    PRIDEi Q9BXC0.

    Protocols and materials databases

    DNASUi 27198.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000432564 ; ENSP00000389255 ; ENSG00000196917 .
    GeneIDi 27198.
    KEGGi hsa:27198.
    UCSCi uc001ucz.3. human.

    Organism-specific databases

    CTDi 27198.
    GeneCardsi GC12M123104.
    H-InvDB HIX0026348.
    HGNCi HGNC:4532. HCAR1.
    MIMi 606923. gene.
    neXtProti NX_Q9BXC0.
    PharmGKBi PA28925.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG148165.
    HOVERGENi HBG051680.
    InParanoidi Q9BXC0.
    KOi K08401.
    OMAi LAMNRAG.
    OrthoDBi EOG7R56SR.
    PhylomeDBi Q9BXC0.
    TreeFami TF330775.

    Enzyme and pathway databases

    Reactomei REACT_163785. Hydroxycarboxylic acid-binding receptors.
    REACT_19231. G alpha (i) signalling events.

    Miscellaneous databases

    GeneWikii GPR81.
    GenomeRNAii 27198.
    NextBioi 50062.
    PROi Q9BXC0.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9BXC0.
    CleanExi HS_GPR81.
    Genevestigatori Q9BXC0.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR028016. HCAR1_rcpt.
    [Graphical view ]
    PANTHERi PTHR24231:SF29. PTHR24231:SF29. 1 hit.
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Discovery and mapping of ten novel G protein-coupled receptor genes."
      Lee D.K., Nguyen T., Lynch K.R., Cheng R., Vanti W.B., Arkhitko O., Lewis T., Evans J.F., George S.R., O'Dowd B.F.
      Gene 275:83-91(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], TISSUE SPECIFICITY.
    2. "Lactate inhibits lipolysis in fat cells through activation of an orphan G-protein-coupled receptor, GPR81."
      Liu C., Wu J., Zhu J., Kuei C., Yu J., Shelton J., Sutton S.W., Li X., Yun S.J., Mirzadegan T., Mazur C., Kamme F., Lovenberg T.W.
      J. Biol. Chem. 284:2811-2822(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, MUTAGENESIS OF ARG-99; TYR-233; ARG-240 AND THR-267.
    3. "Molecular cloning of FKSG80, a novel gene encoding a putative chemokine receptor."
      Wang Y.-G., Gong L.
      Submitted (FEB-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    4. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
      Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
      Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    5. "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
      King M.M., Aronstam R.S., Sharma S.V.
      Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Kidney.
    6. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Spleen.
    7. "Identification of G protein-coupled receptor genes from the human genome sequence."
      Takeda S., Kadowaki S., Haga T., Takaesu H., Mitaku S.
      FEBS Lett. 520:97-101(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    8. SeattleSNPs variation discovery resource
      Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS GLN-43 AND GLU-253.
    9. "The finished DNA sequence of human chromosome 12."
      Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.
      , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
      Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    10. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    11. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    12. "International union of basic and clinical pharmacology. LXXXII: nomenclature and classification of hydroxy-carboxylic acid receptors (GPR81, GPR109A, and GPR109B)."
      Offermanns S., Colletti S.L., Lovenberg T.W., Semple G., Wise A., Ijzerman A.P.
      Pharmacol. Rev. 63:269-290(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: NOMENCLATURE.

    Entry informationi

    Entry nameiHCAR1_HUMAN
    AccessioniPrimary (citable) accession number: Q9BXC0
    Secondary accession number(s): B2R9X4
    , Q3Y5J3, Q4VBN1, Q6NXU5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 10, 2003
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 116 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 12
      Human chromosome 12: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3