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Q9BXB5

- OSB10_HUMAN

UniProt

Q9BXB5 - OSB10_HUMAN

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Protein

Oxysterol-binding protein-related protein 10

Gene

OSBPL10

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. cholesterol binding Source: BHF-UCL

GO - Biological processi

  1. lipid transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Lipid transport, Transport

Keywords - Ligandi

Lipid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Oxysterol-binding protein-related protein 10
Short name:
ORP-10
Short name:
OSBP-related protein 10
Gene namesi
Name:OSBPL10
Synonyms:ORP10, OSBP9
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 3

Organism-specific databases

HGNCiHGNC:16395. OSBPL10.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32824.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 764764Oxysterol-binding protein-related protein 10PRO_0000100380Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei57 – 571Phosphoserine1 Publication
Modified residuei60 – 601Phosphoserine1 Publication
Modified residuei64 – 641Phosphoserine2 Publications
Modified residuei196 – 1961Phosphothreonine1 Publication
Modified residuei201 – 2011Phosphoserine1 Publication
Modified residuei209 – 2091Phosphoserine2 Publications
Modified residuei223 – 2231Phosphoserine2 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9BXB5.
PaxDbiQ9BXB5.
PRIDEiQ9BXB5.

PTM databases

PhosphoSiteiQ9BXB5.

Expressioni

Gene expression databases

BgeeiQ9BXB5.
CleanExiHS_OSBPL10.
ExpressionAtlasiQ9BXB5. baseline and differential.
GenevestigatoriQ9BXB5.

Organism-specific databases

HPAiHPA003636.

Interactioni

Protein-protein interaction databases

BioGridi125385. 19 interactions.
IntActiQ9BXB5. 17 interactions.
STRINGi9606.ENSP00000273142.

Structurei

3D structure databases

ProteinModelPortaliQ9BXB5.
SMRiQ9BXB5. Positions 79-184, 398-753.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini74 – 17198PHPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the OSBP family.Curated
Contains 1 PH domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG262374.
GeneTreeiENSGT00550000074515.
HOGENOMiHOG000233871.
HOVERGENiHBG053376.
InParanoidiQ9BXB5.
OMAiAKYHMET.
OrthoDBiEOG7PK8ZG.
PhylomeDBiQ9BXB5.
TreeFamiTF312807.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR000648. Oxysterol-bd.
IPR018494. Oxysterol-bd_CS.
IPR001849. PH_domain.
IPR011993. PH_like_dom.
[Graphical view]
PANTHERiPTHR10972. PTHR10972. 1 hit.
PfamiPF01237. Oxysterol_BP. 1 hit.
[Graphical view]
SMARTiSM00233. PH. 1 hit.
[Graphical view]
PROSITEiPS01013. OSBP. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9BXB5-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MERAVQGTDG GGGSNSSSRS SSRATSAGSS PSCSLAGRGV SSRSAAAGLG
60 70 80 90 100
GGGSRSSPGS VAASPSGGGG RRREPALEGV LSKYTNLLQG WQNRYFVLDF
110 120 130 140 150
EAGILQYFVN EQSKHQKPRG VLSLSGAIVS LSDEAPHMLV VYSANGEMFK
160 170 180 190 200
LRAADAKEKQ FWVTQLRACA KYHMEMNSKS APSSRSRSLT LLPHGTPNSA
210 220 230 240 250
SPCSQRHLSV GAPGVVTITH HKSPAAARRA KSQYSGQLHE VREMMNQVEG
260 270 280 290 300
QQKNLVHAIE SLPGSGPLTA LDQDLLLLKA TSAATLSCLG ECLNLLQQSV
310 320 330 340 350
HQAGQPSQKP GASENILGWH GSKSHSTEQL KNGTLGSLPS ASANITWAIL
360 370 380 390 400
PNSAEDEQTS QPEPEPNSGS ELVLSEDEKS DNEDKEETEL GVMEDQRSII
410 420 430 440 450
LHLISQLKLG MDLTKVVLPT FILEKRSLLE MYADFMAHPD LLLAITAGAT
460 470 480 490 500
PEERVICFVE YYLTAFHEGR KGALAKKPYN PIIGETFHCS WEVPKDRVKP
510 520 530 540 550
KRTASRSPAS CHEHPMADDP SKSYKLRFVA EQVSHHPPIS CFYCECEEKR
560 570 580 590 600
LCVNTHVWTK SKFMGMSVGV SMIGEGVLRL LEHGEEYVFT LPSAYARSIL
610 620 630 640 650
TIPWVELGGK VSINCAKTGY SATVIFHTKP FYGGKVHRVT AEVKHNPTNT
660 670 680 690 700
IVCKAHGEWN GTLEFTYNNG ETKVIDTTTL PVYPKKIRPL EKQGPMESRN
710 720 730 740 750
LWREVTRYLR LGDIDAATEQ KRHLEEKQRV EERKRENLRT PWKPKYFIQE
760
GDGWVYFNPL WKAH
Length:764
Mass (Da):83,970
Last modified:February 11, 2002 - v2
Checksum:i62B1DF599C7C15FC
GO
Isoform 2 (identifier: Q9BXB5-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     180-243: Missing.

Note: No experimental confirmation available.

Show »
Length:700
Mass (Da):77,235
Checksum:i1D4F1CE7D3B3C164
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti254 – 2541N → D.
Corresponds to variant rs2290532 [ dbSNP | Ensembl ].
VAR_022100

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei180 – 24364Missing in isoform 2. 1 PublicationVSP_042930Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF392451 mRNA. Translation: AAL40664.1.
AK304067 mRNA. Translation: BAG64974.1.
AC092024 Genomic DNA. No translation available.
AC094019 Genomic DNA. No translation available.
AC107620 Genomic DNA. No translation available.
AC108485 Genomic DNA. No translation available.
BC003168 mRNA. Translation: AAH03168.2.
AF346291 mRNA. Translation: AAK31140.1.
CCDSiCCDS2651.1. [Q9BXB5-1]
CCDS54559.1. [Q9BXB5-2]
RefSeqiNP_001167531.1. NM_001174060.1. [Q9BXB5-2]
NP_060254.2. NM_017784.4. [Q9BXB5-1]
UniGeneiHs.150122.

Genome annotation databases

EnsembliENST00000396556; ENSP00000379804; ENSG00000144645. [Q9BXB5-1]
ENST00000438237; ENSP00000406124; ENSG00000144645. [Q9BXB5-2]
GeneIDi114884.
KEGGihsa:114884.
UCSCiuc011axf.2. human. [Q9BXB5-2]
uc021wuu.1. human. [Q9BXB5-1]

Polymorphism databases

DMDMi20139128.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF392451 mRNA. Translation: AAL40664.1 .
AK304067 mRNA. Translation: BAG64974.1 .
AC092024 Genomic DNA. No translation available.
AC094019 Genomic DNA. No translation available.
AC107620 Genomic DNA. No translation available.
AC108485 Genomic DNA. No translation available.
BC003168 mRNA. Translation: AAH03168.2 .
AF346291 mRNA. Translation: AAK31140.1 .
CCDSi CCDS2651.1. [Q9BXB5-1 ]
CCDS54559.1. [Q9BXB5-2 ]
RefSeqi NP_001167531.1. NM_001174060.1. [Q9BXB5-2 ]
NP_060254.2. NM_017784.4. [Q9BXB5-1 ]
UniGenei Hs.150122.

3D structure databases

ProteinModelPortali Q9BXB5.
SMRi Q9BXB5. Positions 79-184, 398-753.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 125385. 19 interactions.
IntActi Q9BXB5. 17 interactions.
STRINGi 9606.ENSP00000273142.

PTM databases

PhosphoSitei Q9BXB5.

Polymorphism databases

DMDMi 20139128.

Proteomic databases

MaxQBi Q9BXB5.
PaxDbi Q9BXB5.
PRIDEi Q9BXB5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000396556 ; ENSP00000379804 ; ENSG00000144645 . [Q9BXB5-1 ]
ENST00000438237 ; ENSP00000406124 ; ENSG00000144645 . [Q9BXB5-2 ]
GeneIDi 114884.
KEGGi hsa:114884.
UCSCi uc011axf.2. human. [Q9BXB5-2 ]
uc021wuu.1. human. [Q9BXB5-1 ]

Organism-specific databases

CTDi 114884.
GeneCardsi GC03M031677.
HGNCi HGNC:16395. OSBPL10.
HPAi HPA003636.
MIMi 606738. gene.
neXtProti NX_Q9BXB5.
PharmGKBi PA32824.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG262374.
GeneTreei ENSGT00550000074515.
HOGENOMi HOG000233871.
HOVERGENi HBG053376.
InParanoidi Q9BXB5.
OMAi AKYHMET.
OrthoDBi EOG7PK8ZG.
PhylomeDBi Q9BXB5.
TreeFami TF312807.

Miscellaneous databases

ChiTaRSi OSBPL10. human.
GenomeRNAii 114884.
NextBioi 79385.
PROi Q9BXB5.
SOURCEi Search...

Gene expression databases

Bgeei Q9BXB5.
CleanExi HS_OSBPL10.
ExpressionAtlasi Q9BXB5. baseline and differential.
Genevestigatori Q9BXB5.

Family and domain databases

Gene3Di 2.30.29.30. 1 hit.
InterProi IPR000648. Oxysterol-bd.
IPR018494. Oxysterol-bd_CS.
IPR001849. PH_domain.
IPR011993. PH_like_dom.
[Graphical view ]
PANTHERi PTHR10972. PTHR10972. 1 hit.
Pfami PF01237. Oxysterol_BP. 1 hit.
[Graphical view ]
SMARTi SM00233. PH. 1 hit.
[Graphical view ]
PROSITEi PS01013. OSBP. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A family of 12 human genes containing oxysterol-binding domains."
    Jaworski C.J., Moreira E., Li A., Lee R., Rodriguez I.R.
    Genomics 78:185-196(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Trachea.
  3. "The DNA sequence, annotation and analysis of human chromosome 3."
    Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
    , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
    Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Skin.
  5. "The OSBP-related protein family in humans."
    Lehto M., Laitinen S., Chinetti G., Johansson M., Ehnholm C., Staels B., Ikonen E., Olkkonen V.M.
    J. Lipid Res. 42:1203-1213(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-251 (ISOFORM 1).
  6. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."
    Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.
    Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-64, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  7. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
    Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
    Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  8. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-57; SER-60; SER-64; THR-196; SER-201 AND SER-223, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  9. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-209 AND SER-223, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  10. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-209, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiOSB10_HUMAN
AccessioniPrimary (citable) accession number: Q9BXB5
Secondary accession number(s): B4E212, Q9BTU5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 11, 2002
Last sequence update: February 11, 2002
Last modified: November 26, 2014
This is version 107 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3