Q9BXB5 (OSB10_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Oxysterol-binding protein-related protein 10
Short name=ORP-10
Short name=OSBP-related protein 10

Gene names

Name:	OSBPL10
Synonyms:	ORP10, OSBP9

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	764 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Sequence similarities

Belongs to the OSBP family. Contains 1 PH domain.

Ontologies

Keywords
Biological process	Lipid transport Transport
Coding sequence diversity	Alternative splicing Polymorphism
Ligand	Lipid-binding
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	lipid transport Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	cholesterol binding Inferred from direct assay PubMed 17428193. Source: BHF-UCL phospholipid binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9BXB5-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9BXB5-2)

The sequence of this isoform differs from the canonical sequence as follows:
     180-243: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 764	764	Oxysterol-binding protein-related protein 10		PRO_0000100380
Regions
	Domain	74 – 171	98	PH
Amino acid modifications
	Modified residue	57	1	Phosphoserine Ref.8
	Modified residue	60	1	Phosphoserine Ref.8
	Modified residue	64	1	Phosphoserine Ref.6 Ref.8
	Modified residue	196	1	Phosphothreonine Ref.8
	Modified residue	201	1	Phosphoserine Ref.8
	Modified residue	209	1	Phosphoserine Ref.9 Ref.10
	Modified residue	223	1	Phosphoserine Ref.8 Ref.9
Natural variations
	Alternative sequence	180 – 243	64	Missing in isoform 2.		VSP_042930
	Natural variant	254	1	N → D. Corresponds to variant rs2290532 [ dbSNP | Ensembl ].		VAR_022100

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified February 11, 2002. Version 2. Checksum: 62B1DF599C7C15FC	FASTA	764	83,970
	10 20 30 40 50 60 MERAVQGTDG GGGSNSSSRS SSRATSAGSS PSCSLAGRGV SSRSAAAGLG GGGSRSSPGS 70 80 90 100 110 120 VAASPSGGGG RRREPALEGV LSKYTNLLQG WQNRYFVLDF EAGILQYFVN EQSKHQKPRG 130 140 150 160 170 180 VLSLSGAIVS LSDEAPHMLV VYSANGEMFK LRAADAKEKQ FWVTQLRACA KYHMEMNSKS 190 200 210 220 230 240 APSSRSRSLT LLPHGTPNSA SPCSQRHLSV GAPGVVTITH HKSPAAARRA KSQYSGQLHE 250 260 270 280 290 300 VREMMNQVEG QQKNLVHAIE SLPGSGPLTA LDQDLLLLKA TSAATLSCLG ECLNLLQQSV 310 320 330 340 350 360 HQAGQPSQKP GASENILGWH GSKSHSTEQL KNGTLGSLPS ASANITWAIL PNSAEDEQTS 370 380 390 400 410 420 QPEPEPNSGS ELVLSEDEKS DNEDKEETEL GVMEDQRSII LHLISQLKLG MDLTKVVLPT 430 440 450 460 470 480 FILEKRSLLE MYADFMAHPD LLLAITAGAT PEERVICFVE YYLTAFHEGR KGALAKKPYN 490 500 510 520 530 540 PIIGETFHCS WEVPKDRVKP KRTASRSPAS CHEHPMADDP SKSYKLRFVA EQVSHHPPIS 550 560 570 580 590 600 CFYCECEEKR LCVNTHVWTK SKFMGMSVGV SMIGEGVLRL LEHGEEYVFT LPSAYARSIL 610 620 630 640 650 660 TIPWVELGGK VSINCAKTGY SATVIFHTKP FYGGKVHRVT AEVKHNPTNT IVCKAHGEWN 670 680 690 700 710 720 GTLEFTYNNG ETKVIDTTTL PVYPKKIRPL EKQGPMESRN LWREVTRYLR LGDIDAATEQ 730 740 750 760 KRHLEEKQRV EERKRENLRT PWKPKYFIQE GDGWVYFNPL WKAH
	Isoform 2 [UniParc]. Checksum: 1D4F1CE7D3B3C164	FASTA	700	77,235
	10 20 30 40 50 60 MERAVQGTDG GGGSNSSSRS SSRATSAGSS PSCSLAGRGV SSRSAAAGLG GGGSRSSPGS 70 80 90 100 110 120 VAASPSGGGG RRREPALEGV LSKYTNLLQG WQNRYFVLDF EAGILQYFVN EQSKHQKPRG 130 140 150 160 170 180 VLSLSGAIVS LSDEAPHMLV VYSANGEMFK LRAADAKEKQ FWVTQLRACA KYHMEMNSKM 190 200 210 220 230 240 MNQVEGQQKN LVHAIESLPG SGPLTALDQD LLLLKATSAA TLSCLGECLN LLQQSVHQAG 250 260 270 280 290 300 QPSQKPGASE NILGWHGSKS HSTEQLKNGT LGSLPSASAN ITWAILPNSA EDEQTSQPEP 310 320 330 340 350 360 EPNSGSELVL SEDEKSDNED KEETELGVME DQRSIILHLI SQLKLGMDLT KVVLPTFILE 370 380 390 400 410 420 KRSLLEMYAD FMAHPDLLLA ITAGATPEER VICFVEYYLT AFHEGRKGAL AKKPYNPIIG 430 440 450 460 470 480 ETFHCSWEVP KDRVKPKRTA SRSPASCHEH PMADDPSKSY KLRFVAEQVS HHPPISCFYC 490 500 510 520 530 540 ECEEKRLCVN THVWTKSKFM GMSVGVSMIG EGVLRLLEHG EEYVFTLPSA YARSILTIPW 550 560 570 580 590 600 VELGGKVSIN CAKTGYSATV IFHTKPFYGG KVHRVTAEVK HNPTNTIVCK AHGEWNGTLE 610 620 630 640 650 660 FTYNNGETKV IDTTTLPVYP KKIRPLEKQG PMESRNLWRE VTRYLRLGDI DAATEQKRHL 670 680 690 700 EEKQRVEERK RENLRTPWKP KYFIQEGDGW VYFNPLWKAH

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A family of 12 human genes containing oxysterol-binding domains." Jaworski C.J., Moreira E., Li A., Lee R., Rodriguez I.R. Genomics 78:185-196(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Trachea.
[3]	"The DNA sequence, annotation and analysis of human chromosome 3." Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J. , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A. Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Skin.
[5]	"The OSBP-related protein family in humans." Lehto M., Laitinen S., Chinetti G., Johansson M., Ehnholm C., Staels B., Ikonen E., Olkkonen V.M. J. Lipid Res. 42:1203-1213(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-251 (ISOFORM 1).
[6]	"A probability-based approach for high-throughput protein phosphorylation analysis and site localization." Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P. Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-64, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[7]	"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle." Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M. Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Cervix carcinoma.
[8]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-57; SER-60; SER-64; THR-196; SER-201 AND SER-223, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[9]	"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis." Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M. Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-209 AND SER-223, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[10]	"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation." Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B. Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-209, MASS SPECTROMETRY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF392451 mRNA. Translation: AAL40664.1. AK304067 mRNA. Translation: BAG64974.1. AC092024 Genomic DNA. No translation available. AC094019 Genomic DNA. No translation available. AC107620 Genomic DNA. No translation available. AC108485 Genomic DNA. No translation available. BC003168 mRNA. Translation: AAH03168.2. AF346291 mRNA. Translation: AAK31140.1.
IPI	IPI00032971. IPI00794866.
RefSeq	NP_001167531.1. NM_001174060.1. NP_060254.2. NM_017784.4.
UniGene	Hs.150122.
3D structure databases
ProteinModelPortal	Q9BXB5.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9BXB5. 17 interactions.
STRING	9606.ENSP00000273142.
PTM databases
PhosphoSite	Q9BXB5.
Polymorphism databases
DMDM	20139128.
Proteomic databases
PaxDb	Q9BXB5.
PRIDE	Q9BXB5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000396556; ENSP00000379804; ENSG00000144645. ENST00000438237; ENSP00000406124; ENSG00000144645.
GeneID	114884.
KEGG	hsa:114884.
UCSC	uc021wuu.1. human.
Organism-specific databases
CTD	114884.
GeneCards	GC03M031677.
HGNC	HGNC:16395. OSBPL10.
HPA	HPA003636.
MIM	606738. gene.
neXtProt	NX_Q9BXB5.
PharmGKB	PA32824.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG262374.
HOGENOM	HOG000233871.
HOVERGEN	HBG053376.
InParanoid	Q9BXB5.
OMA	AKYHMET.
OrthoDB	EOG4MGS76.
PhylomeDB	Q9BXB5.
Gene expression databases
ArrayExpress	Q9BXB5.
Bgee	Q9BXB5.
CleanEx	HS_OSBPL10.
Genevestigator	Q9BXB5.
GermOnline	ENSG00000144645. Homo sapiens.
Family and domain databases
Gene3D	2.30.29.30. 1 hit.
InterPro	IPR000648. Oxysterol-bd. IPR018494. Oxysterol-bd_CS. IPR011993. PH_like_dom. IPR001849. Pleckstrin_homology. [Graphical view]
PANTHER	PTHR10972. PTHR10972. 1 hit.
Pfam	PF01237. Oxysterol_BP. 1 hit. PF00169. PH. 1 hit. [Graphical view]
SMART	SM00233. PH. 1 hit. [Graphical view]
PROSITE	PS01013. OSBP. 1 hit. PS50003. PH_DOMAIN. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	OSBPL10. human.
GenomeRNAi	114884.
NextBio	79385.
SOURCE	Search...

Entry information

Entry name

OSB10_HUMAN

Accession

Primary (citable) accession number: Q9BXB5
Secondary accession number(s): B4E212, Q9BTU5

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 11, 2002
Last sequence update:	February 11, 2002
Last modified:	May 1, 2013
This is version 93 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.