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Protein

Oxysterol-binding protein-related protein 10

Gene

OSBPL10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Probable lipid transporter involved in lipid countertransport between the endoplasmic reticulum and the plasma membrane. Its ability to bind phosphatidylserine, suggests that it specifically exchanges phosphatidylserine with phosphatidylinositol 4-phosphate (PI4P), delivering phosphatidylserine to the plasma membrane in exchange for PI4P (PubMed:23934110) (Probable). Plays a role in negative regulation of lipid biosynthesis (PubMed:19554302). Negatively regulates APOB secretion from hepatocytes (PubMed:19554302, PubMed:22906437). Binds cholesterol and acidic phospholipids (PubMed:22906437). Also binds 25-hydroxycholesterol (PubMed:17428193). Binds phosphatidylserine (PubMed:23934110).Curated4 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei480PhosphatidylserineBy similarity1
Binding sitei561PhosphatidylserineBy similarity1
Binding sitei721Phosphatidylinositol 4-phosphateBy similarity1
Binding sitei725Phosphatidylinositol 4-phosphateBy similarity1
Binding sitei729Phosphatidylinositol 4-phosphateBy similarity1

GO - Molecular functioni

  • cholesterol binding Source: BHF-UCL
  • phosphatidylserine binding Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Lipid biosynthesis, Lipid metabolism, Lipid transport, Transport

Keywords - Ligandi

Lipid-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000144645-MONOMER.
ReactomeiR-HSA-1482801. Acyl chain remodelling of PS.

Chemistry databases

SwissLipidsiSLP:000000528.

Names & Taxonomyi

Protein namesi
Recommended name:
Oxysterol-binding protein-related protein 10
Short name:
ORP-10
Short name:
OSBP-related protein 10
Gene namesi
Name:OSBPL10
Synonyms:ORP10, OSBP9
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:16395. OSBPL10.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Organism-specific databases

DisGeNETi114884.
OpenTargetsiENSG00000144645.
PharmGKBiPA32824.

Polymorphism and mutation databases

BioMutaiOSBPL10.
DMDMi20139128.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001003801 – 764Oxysterol-binding protein-related protein 10Add BLAST764

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei29PhosphoserineBy similarity1
Modified residuei30PhosphoserineCombined sources1
Modified residuei38Omega-N-methylarginineCombined sources1
Modified residuei57PhosphoserineCombined sources1
Modified residuei60PhosphoserineCombined sources1
Modified residuei64PhosphoserineCombined sources1
Modified residuei196PhosphothreonineCombined sources1
Modified residuei201PhosphoserineCombined sources1
Modified residuei209PhosphoserineCombined sources1
Modified residuei223PhosphoserineCombined sources1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

EPDiQ9BXB5.
MaxQBiQ9BXB5.
PaxDbiQ9BXB5.
PeptideAtlasiQ9BXB5.
PRIDEiQ9BXB5.

PTM databases

iPTMnetiQ9BXB5.
PhosphoSitePlusiQ9BXB5.

Expressioni

Gene expression databases

BgeeiENSG00000144645.
CleanExiHS_OSBPL10.
ExpressionAtlasiQ9BXB5. baseline and differential.
GenevisibleiQ9BXB5. HS.

Organism-specific databases

HPAiHPA003636.

Interactioni

Subunit structurei

Interacts with OSBPL9 (PubMed:22906437). Interacts with DIAPH1 (PubMed:23325789).2 Publications

Protein-protein interaction databases

BioGridi125385. 20 interactors.
IntActiQ9BXB5. 19 interactors.
STRINGi9606.ENSP00000379804.

Structurei

3D structure databases

ProteinModelPortaliQ9BXB5.
SMRiQ9BXB5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini74 – 171PHPROSITE-ProRule annotationAdd BLAST98

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni413 – 418Phosphatidylinositol 4-phosphate bindingBy similarity6
Regioni413 – 418Phosphatidylserine bindingBy similarity6
Regioni477 – 480Phosphatidylinositol 4-phosphate bindingBy similarity4
Regioni535 – 536Phosphatidylinositol 4-phosphate bindingBy similarity2

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili713 – 740Sequence analysisAdd BLAST28

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi14 – 66Ser-richPROSITE-ProRule annotationAdd BLAST53

Domaini

The C-terminal region binds cholesterol, 25-hydroxysterol and acidic phospholipids and is required for localization to microtubules.2 Publications
The PH domain selectively interacts with phosphatidylinositol-4-phosphate.1 Publication

Sequence similaritiesi

Belongs to the OSBP family.Curated
Contains 1 PH domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG2210. Eukaryota.
ENOG410XRW6. LUCA.
GeneTreeiENSGT00550000074515.
HOGENOMiHOG000233871.
HOVERGENiHBG053376.
InParanoidiQ9BXB5.
KOiK20465.
OMAiKPKYFIQ.
OrthoDBiEOG091G0FV2.
PhylomeDBiQ9BXB5.
TreeFamiTF312807.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR000648. Oxysterol-bd.
IPR018494. Oxysterol-bd_CS.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
[Graphical view]
PANTHERiPTHR10972. PTHR10972. 2 hits.
PfamiPF01237. Oxysterol_BP. 1 hit.
[Graphical view]
SMARTiSM00233. PH. 1 hit.
[Graphical view]
SUPFAMiSSF50729. SSF50729. 1 hit.
PROSITEiPS01013. OSBP. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9BXB5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MERAVQGTDG GGGSNSSSRS SSRATSAGSS PSCSLAGRGV SSRSAAAGLG
60 70 80 90 100
GGGSRSSPGS VAASPSGGGG RRREPALEGV LSKYTNLLQG WQNRYFVLDF
110 120 130 140 150
EAGILQYFVN EQSKHQKPRG VLSLSGAIVS LSDEAPHMLV VYSANGEMFK
160 170 180 190 200
LRAADAKEKQ FWVTQLRACA KYHMEMNSKS APSSRSRSLT LLPHGTPNSA
210 220 230 240 250
SPCSQRHLSV GAPGVVTITH HKSPAAARRA KSQYSGQLHE VREMMNQVEG
260 270 280 290 300
QQKNLVHAIE SLPGSGPLTA LDQDLLLLKA TSAATLSCLG ECLNLLQQSV
310 320 330 340 350
HQAGQPSQKP GASENILGWH GSKSHSTEQL KNGTLGSLPS ASANITWAIL
360 370 380 390 400
PNSAEDEQTS QPEPEPNSGS ELVLSEDEKS DNEDKEETEL GVMEDQRSII
410 420 430 440 450
LHLISQLKLG MDLTKVVLPT FILEKRSLLE MYADFMAHPD LLLAITAGAT
460 470 480 490 500
PEERVICFVE YYLTAFHEGR KGALAKKPYN PIIGETFHCS WEVPKDRVKP
510 520 530 540 550
KRTASRSPAS CHEHPMADDP SKSYKLRFVA EQVSHHPPIS CFYCECEEKR
560 570 580 590 600
LCVNTHVWTK SKFMGMSVGV SMIGEGVLRL LEHGEEYVFT LPSAYARSIL
610 620 630 640 650
TIPWVELGGK VSINCAKTGY SATVIFHTKP FYGGKVHRVT AEVKHNPTNT
660 670 680 690 700
IVCKAHGEWN GTLEFTYNNG ETKVIDTTTL PVYPKKIRPL EKQGPMESRN
710 720 730 740 750
LWREVTRYLR LGDIDAATEQ KRHLEEKQRV EERKRENLRT PWKPKYFIQE
760
GDGWVYFNPL WKAH
Length:764
Mass (Da):83,970
Last modified:February 11, 2002 - v2
Checksum:i62B1DF599C7C15FC
GO
Isoform 2 (identifier: Q9BXB5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     180-243: Missing.

Note: No experimental confirmation available.
Show »
Length:700
Mass (Da):77,235
Checksum:i1D4F1CE7D3B3C164
GO

Polymorphismi

Polymorphisms are associated with dyslipidemia. Variant Asn-254 is associated with LDL-cholesterol levels in Japanese population (PubMed:20224571). Association with peripheral arterial disease has also been oberved (PubMed:20610895).2 Publications

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_022100254N → D.Corresponds to variant rs2290532dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_042930180 – 243Missing in isoform 2. 1 PublicationAdd BLAST64

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF392451 mRNA. Translation: AAL40664.1.
AK304067 mRNA. Translation: BAG64974.1.
AC092024 Genomic DNA. No translation available.
AC094019 Genomic DNA. No translation available.
AC107620 Genomic DNA. No translation available.
AC108485 Genomic DNA. No translation available.
BC003168 mRNA. Translation: AAH03168.2.
AF346291 mRNA. Translation: AAK31140.1.
CCDSiCCDS2651.1. [Q9BXB5-1]
CCDS54559.1. [Q9BXB5-2]
RefSeqiNP_001167531.1. NM_001174060.1. [Q9BXB5-2]
NP_060254.2. NM_017784.4. [Q9BXB5-1]
UniGeneiHs.150122.

Genome annotation databases

EnsembliENST00000396556; ENSP00000379804; ENSG00000144645. [Q9BXB5-1]
ENST00000438237; ENSP00000406124; ENSG00000144645. [Q9BXB5-2]
GeneIDi114884.
KEGGihsa:114884.
UCSCiuc011axf.3. human. [Q9BXB5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF392451 mRNA. Translation: AAL40664.1.
AK304067 mRNA. Translation: BAG64974.1.
AC092024 Genomic DNA. No translation available.
AC094019 Genomic DNA. No translation available.
AC107620 Genomic DNA. No translation available.
AC108485 Genomic DNA. No translation available.
BC003168 mRNA. Translation: AAH03168.2.
AF346291 mRNA. Translation: AAK31140.1.
CCDSiCCDS2651.1. [Q9BXB5-1]
CCDS54559.1. [Q9BXB5-2]
RefSeqiNP_001167531.1. NM_001174060.1. [Q9BXB5-2]
NP_060254.2. NM_017784.4. [Q9BXB5-1]
UniGeneiHs.150122.

3D structure databases

ProteinModelPortaliQ9BXB5.
SMRiQ9BXB5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125385. 20 interactors.
IntActiQ9BXB5. 19 interactors.
STRINGi9606.ENSP00000379804.

Chemistry databases

SwissLipidsiSLP:000000528.

PTM databases

iPTMnetiQ9BXB5.
PhosphoSitePlusiQ9BXB5.

Polymorphism and mutation databases

BioMutaiOSBPL10.
DMDMi20139128.

Proteomic databases

EPDiQ9BXB5.
MaxQBiQ9BXB5.
PaxDbiQ9BXB5.
PeptideAtlasiQ9BXB5.
PRIDEiQ9BXB5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000396556; ENSP00000379804; ENSG00000144645. [Q9BXB5-1]
ENST00000438237; ENSP00000406124; ENSG00000144645. [Q9BXB5-2]
GeneIDi114884.
KEGGihsa:114884.
UCSCiuc011axf.3. human. [Q9BXB5-1]

Organism-specific databases

CTDi114884.
DisGeNETi114884.
GeneCardsiOSBPL10.
HGNCiHGNC:16395. OSBPL10.
HPAiHPA003636.
MIMi606738. gene.
neXtProtiNX_Q9BXB5.
OpenTargetsiENSG00000144645.
PharmGKBiPA32824.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2210. Eukaryota.
ENOG410XRW6. LUCA.
GeneTreeiENSGT00550000074515.
HOGENOMiHOG000233871.
HOVERGENiHBG053376.
InParanoidiQ9BXB5.
KOiK20465.
OMAiKPKYFIQ.
OrthoDBiEOG091G0FV2.
PhylomeDBiQ9BXB5.
TreeFamiTF312807.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000144645-MONOMER.
ReactomeiR-HSA-1482801. Acyl chain remodelling of PS.

Miscellaneous databases

ChiTaRSiOSBPL10. human.
GenomeRNAii114884.
PROiQ9BXB5.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000144645.
CleanExiHS_OSBPL10.
ExpressionAtlasiQ9BXB5. baseline and differential.
GenevisibleiQ9BXB5. HS.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR000648. Oxysterol-bd.
IPR018494. Oxysterol-bd_CS.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
[Graphical view]
PANTHERiPTHR10972. PTHR10972. 2 hits.
PfamiPF01237. Oxysterol_BP. 1 hit.
[Graphical view]
SMARTiSM00233. PH. 1 hit.
[Graphical view]
SUPFAMiSSF50729. SSF50729. 1 hit.
PROSITEiPS01013. OSBP. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiOSB10_HUMAN
AccessioniPrimary (citable) accession number: Q9BXB5
Secondary accession number(s): B4E212, Q9BTU5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 11, 2002
Last sequence update: February 11, 2002
Last modified: November 30, 2016
This is version 124 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.