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Q9BXB5

- OSB10_HUMAN

UniProt

Q9BXB5 - OSB10_HUMAN

Protein

Oxysterol-binding protein-related protein 10

Gene

OSBPL10

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 105 (01 Oct 2014)
      Sequence version 2 (11 Feb 2002)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. cholesterol binding Source: BHF-UCL

    GO - Biological processi

    1. lipid transport Source: UniProtKB-KW

    Keywords - Biological processi

    Lipid transport, Transport

    Keywords - Ligandi

    Lipid-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Oxysterol-binding protein-related protein 10
    Short name:
    ORP-10
    Short name:
    OSBP-related protein 10
    Gene namesi
    Name:OSBPL10
    Synonyms:ORP10, OSBP9
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 3

    Organism-specific databases

    HGNCiHGNC:16395. OSBPL10.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA32824.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 764764Oxysterol-binding protein-related protein 10PRO_0000100380Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei57 – 571Phosphoserine1 Publication
    Modified residuei60 – 601Phosphoserine1 Publication
    Modified residuei64 – 641Phosphoserine2 Publications
    Modified residuei196 – 1961Phosphothreonine1 Publication
    Modified residuei201 – 2011Phosphoserine1 Publication
    Modified residuei209 – 2091Phosphoserine2 Publications
    Modified residuei223 – 2231Phosphoserine2 Publications

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ9BXB5.
    PaxDbiQ9BXB5.
    PRIDEiQ9BXB5.

    PTM databases

    PhosphoSiteiQ9BXB5.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9BXB5.
    BgeeiQ9BXB5.
    CleanExiHS_OSBPL10.
    GenevestigatoriQ9BXB5.

    Organism-specific databases

    HPAiHPA003636.

    Interactioni

    Protein-protein interaction databases

    BioGridi125385. 18 interactions.
    IntActiQ9BXB5. 17 interactions.
    STRINGi9606.ENSP00000273142.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9BXB5.
    SMRiQ9BXB5. Positions 79-184, 398-753.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini74 – 17198PHPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the OSBP family.Curated
    Contains 1 PH domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG262374.
    HOGENOMiHOG000233871.
    HOVERGENiHBG053376.
    InParanoidiQ9BXB5.
    OMAiAKYHMET.
    OrthoDBiEOG7PK8ZG.
    PhylomeDBiQ9BXB5.
    TreeFamiTF312807.

    Family and domain databases

    Gene3Di2.30.29.30. 1 hit.
    InterProiIPR000648. Oxysterol-bd.
    IPR018494. Oxysterol-bd_CS.
    IPR001849. PH_domain.
    IPR011993. PH_like_dom.
    [Graphical view]
    PANTHERiPTHR10972. PTHR10972. 1 hit.
    PfamiPF01237. Oxysterol_BP. 1 hit.
    [Graphical view]
    SMARTiSM00233. PH. 1 hit.
    [Graphical view]
    PROSITEiPS01013. OSBP. 1 hit.
    PS50003. PH_DOMAIN. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9BXB5-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MERAVQGTDG GGGSNSSSRS SSRATSAGSS PSCSLAGRGV SSRSAAAGLG    50
    GGGSRSSPGS VAASPSGGGG RRREPALEGV LSKYTNLLQG WQNRYFVLDF 100
    EAGILQYFVN EQSKHQKPRG VLSLSGAIVS LSDEAPHMLV VYSANGEMFK 150
    LRAADAKEKQ FWVTQLRACA KYHMEMNSKS APSSRSRSLT LLPHGTPNSA 200
    SPCSQRHLSV GAPGVVTITH HKSPAAARRA KSQYSGQLHE VREMMNQVEG 250
    QQKNLVHAIE SLPGSGPLTA LDQDLLLLKA TSAATLSCLG ECLNLLQQSV 300
    HQAGQPSQKP GASENILGWH GSKSHSTEQL KNGTLGSLPS ASANITWAIL 350
    PNSAEDEQTS QPEPEPNSGS ELVLSEDEKS DNEDKEETEL GVMEDQRSII 400
    LHLISQLKLG MDLTKVVLPT FILEKRSLLE MYADFMAHPD LLLAITAGAT 450
    PEERVICFVE YYLTAFHEGR KGALAKKPYN PIIGETFHCS WEVPKDRVKP 500
    KRTASRSPAS CHEHPMADDP SKSYKLRFVA EQVSHHPPIS CFYCECEEKR 550
    LCVNTHVWTK SKFMGMSVGV SMIGEGVLRL LEHGEEYVFT LPSAYARSIL 600
    TIPWVELGGK VSINCAKTGY SATVIFHTKP FYGGKVHRVT AEVKHNPTNT 650
    IVCKAHGEWN GTLEFTYNNG ETKVIDTTTL PVYPKKIRPL EKQGPMESRN 700
    LWREVTRYLR LGDIDAATEQ KRHLEEKQRV EERKRENLRT PWKPKYFIQE 750
    GDGWVYFNPL WKAH 764
    Length:764
    Mass (Da):83,970
    Last modified:February 11, 2002 - v2
    Checksum:i62B1DF599C7C15FC
    GO
    Isoform 2 (identifier: Q9BXB5-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         180-243: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:700
    Mass (Da):77,235
    Checksum:i1D4F1CE7D3B3C164
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti254 – 2541N → D.
    Corresponds to variant rs2290532 [ dbSNP | Ensembl ].
    VAR_022100

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei180 – 24364Missing in isoform 2. 1 PublicationVSP_042930Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF392451 mRNA. Translation: AAL40664.1.
    AK304067 mRNA. Translation: BAG64974.1.
    AC092024 Genomic DNA. No translation available.
    AC094019 Genomic DNA. No translation available.
    AC107620 Genomic DNA. No translation available.
    AC108485 Genomic DNA. No translation available.
    BC003168 mRNA. Translation: AAH03168.2.
    AF346291 mRNA. Translation: AAK31140.1.
    CCDSiCCDS2651.1. [Q9BXB5-1]
    CCDS54559.1. [Q9BXB5-2]
    RefSeqiNP_001167531.1. NM_001174060.1. [Q9BXB5-2]
    NP_060254.2. NM_017784.4. [Q9BXB5-1]
    UniGeneiHs.150122.

    Genome annotation databases

    EnsembliENST00000396556; ENSP00000379804; ENSG00000144645. [Q9BXB5-1]
    ENST00000438237; ENSP00000406124; ENSG00000144645. [Q9BXB5-2]
    GeneIDi114884.
    KEGGihsa:114884.
    UCSCiuc011axf.2. human. [Q9BXB5-2]
    uc021wuu.1. human. [Q9BXB5-1]

    Polymorphism databases

    DMDMi20139128.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF392451 mRNA. Translation: AAL40664.1 .
    AK304067 mRNA. Translation: BAG64974.1 .
    AC092024 Genomic DNA. No translation available.
    AC094019 Genomic DNA. No translation available.
    AC107620 Genomic DNA. No translation available.
    AC108485 Genomic DNA. No translation available.
    BC003168 mRNA. Translation: AAH03168.2 .
    AF346291 mRNA. Translation: AAK31140.1 .
    CCDSi CCDS2651.1. [Q9BXB5-1 ]
    CCDS54559.1. [Q9BXB5-2 ]
    RefSeqi NP_001167531.1. NM_001174060.1. [Q9BXB5-2 ]
    NP_060254.2. NM_017784.4. [Q9BXB5-1 ]
    UniGenei Hs.150122.

    3D structure databases

    ProteinModelPortali Q9BXB5.
    SMRi Q9BXB5. Positions 79-184, 398-753.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 125385. 18 interactions.
    IntActi Q9BXB5. 17 interactions.
    STRINGi 9606.ENSP00000273142.

    PTM databases

    PhosphoSitei Q9BXB5.

    Polymorphism databases

    DMDMi 20139128.

    Proteomic databases

    MaxQBi Q9BXB5.
    PaxDbi Q9BXB5.
    PRIDEi Q9BXB5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000396556 ; ENSP00000379804 ; ENSG00000144645 . [Q9BXB5-1 ]
    ENST00000438237 ; ENSP00000406124 ; ENSG00000144645 . [Q9BXB5-2 ]
    GeneIDi 114884.
    KEGGi hsa:114884.
    UCSCi uc011axf.2. human. [Q9BXB5-2 ]
    uc021wuu.1. human. [Q9BXB5-1 ]

    Organism-specific databases

    CTDi 114884.
    GeneCardsi GC03M031677.
    HGNCi HGNC:16395. OSBPL10.
    HPAi HPA003636.
    MIMi 606738. gene.
    neXtProti NX_Q9BXB5.
    PharmGKBi PA32824.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG262374.
    HOGENOMi HOG000233871.
    HOVERGENi HBG053376.
    InParanoidi Q9BXB5.
    OMAi AKYHMET.
    OrthoDBi EOG7PK8ZG.
    PhylomeDBi Q9BXB5.
    TreeFami TF312807.

    Miscellaneous databases

    ChiTaRSi OSBPL10. human.
    GenomeRNAii 114884.
    NextBioi 79385.
    PROi Q9BXB5.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9BXB5.
    Bgeei Q9BXB5.
    CleanExi HS_OSBPL10.
    Genevestigatori Q9BXB5.

    Family and domain databases

    Gene3Di 2.30.29.30. 1 hit.
    InterProi IPR000648. Oxysterol-bd.
    IPR018494. Oxysterol-bd_CS.
    IPR001849. PH_domain.
    IPR011993. PH_like_dom.
    [Graphical view ]
    PANTHERi PTHR10972. PTHR10972. 1 hit.
    Pfami PF01237. Oxysterol_BP. 1 hit.
    [Graphical view ]
    SMARTi SM00233. PH. 1 hit.
    [Graphical view ]
    PROSITEi PS01013. OSBP. 1 hit.
    PS50003. PH_DOMAIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A family of 12 human genes containing oxysterol-binding domains."
      Jaworski C.J., Moreira E., Li A., Lee R., Rodriguez I.R.
      Genomics 78:185-196(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Trachea.
    3. "The DNA sequence, annotation and analysis of human chromosome 3."
      Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
      , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
      Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Skin.
    5. "The OSBP-related protein family in humans."
      Lehto M., Laitinen S., Chinetti G., Johansson M., Ehnholm C., Staels B., Ikonen E., Olkkonen V.M.
      J. Lipid Res. 42:1203-1213(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-251 (ISOFORM 1).
    6. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."
      Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.
      Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-64, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    7. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
      Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
      Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    8. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-57; SER-60; SER-64; THR-196; SER-201 AND SER-223, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    9. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-209 AND SER-223, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    10. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-209, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiOSB10_HUMAN
    AccessioniPrimary (citable) accession number: Q9BXB5
    Secondary accession number(s): B4E212, Q9BTU5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 11, 2002
    Last sequence update: February 11, 2002
    Last modified: October 1, 2014
    This is version 105 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 3
      Human chromosome 3: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3