Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Leucine-rich repeat-containing G-protein coupled receptor 4

Gene

LGR4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and is involved in the formation of various organs. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal. Its function as activator of the Wnt signaling pathway is required for the development of various organs, including liver, kidney, intestine, bone, reproductive tract and eye. May also act as a receptor for norrin (NDP), such results however require additional confirmation in vivo. Required during spermatogenesis to activate the Wnt signaling pathway in peritubular myoid cells. Required for the maintenance of intestinal stem cells and Paneth cell differentiation in postnatal intestinal crypts. Acts as a regulator of bone formation and remodeling. Involved in kidney development; required for maintaining the ureteric bud in an undifferentiated state. Involved in the development of the anterior segment of the eye. Required during erythropoiesis. Also acts as a negative regulator of innate immunity by inhibiting TLR2/TLR4 associated pattern-recognition and proinflammatory cytokine production. Plays an important role in regulating the circadian rhythms of plasma lipids, partially through regulating the rhythmic expression of MTTP (By similarity).By similarity6 Publications

GO - Molecular functioni

  • G-protein coupled receptor activity Source: ProtInc
  • transmembrane signaling receptor activity Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Biological rhythms, Differentiation, Immunity, Innate immunity, Spermatogenesis, Wnt signaling pathway

Enzyme and pathway databases

ReactomeiR-HSA-4641263. Regulation of FZD by ubiquitination.
SIGNORiQ9BXB1.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine-rich repeat-containing G-protein coupled receptor 4
Alternative name(s):
G-protein coupled receptor 48
Gene namesi
Name:LGR4
Synonyms:GPR48
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:13299. LGR4.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini25 – 544520ExtracellularSequence analysisAdd
BLAST
Transmembranei545 – 56521Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini566 – 57510CytoplasmicSequence analysis
Transmembranei576 – 59621Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini597 – 62024ExtracellularSequence analysisAdd
BLAST
Transmembranei621 – 64121Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini642 – 66120CytoplasmicSequence analysisAdd
BLAST
Transmembranei662 – 68221Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini683 – 70321ExtracellularSequence analysisAdd
BLAST
Transmembranei704 – 72421Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini725 – 75632CytoplasmicSequence analysisAdd
BLAST
Transmembranei757 – 77721Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini778 – 7836ExtracellularSequence analysis
Transmembranei784 – 80421Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini805 – 951147CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of plasma membrane Source: UniProtKB
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Involvement in diseasei

Osteoporosis (OSTEOP)1 Publication
Disease susceptibility may be associated with variations affecting the gene represented in this entry. A LGR4 nonsense mutation creating a stop codon after position 126 (c.376C>T) is strongly associated with low bone mineral density and osteoporotic fractures (PubMed:23644456). This mutation probably causes degradation of the transcript by nonsense-mediated decay (NMD). The c.376C>T mutation is also associated with electrolyte imbalance, late onset of menarche and reduced testosterone levels, as well as an increased risk of squamous cell carcinoma of the skin and biliary tract cancer (PubMed:23644456).1 Publication
Disease descriptionA systemic skeletal disorder characterized by decreased bone mass and deterioration of bone microarchitecture without alteration in the composition of bone. The result is fragile bones and an increased risk of fractures, even after minimal trauma. Osteoporosis is a chronic condition of multifactorial etiology and is usually clinically silent until a fracture occurs.
See also OMIM:166710

Organism-specific databases

MalaCardsiLGR4.
MIMi166710. phenotype.
615311. phenotype.
PharmGKBiPA28893.

Chemistry

GuidetoPHARMACOLOGYi147.

Polymorphism and mutation databases

BioMutaiLGR4.
DMDMi212286375.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424Sequence analysisAdd
BLAST
Chaini25 – 951927Leucine-rich repeat-containing G-protein coupled receptor 4PRO_0000012792Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi29 ↔ 35PROSITE-ProRule annotation1 Publication
Disulfide bondi33 ↔ 43PROSITE-ProRule annotation1 Publication
Glycosylationi68 – 681N-linked (GlcNAc...)1 Publication
Glycosylationi199 – 1991N-linked (GlcNAc...)1 Publication
Glycosylationi294 – 2941N-linked (GlcNAc...)Sequence analysis
Glycosylationi314 – 3141N-linked (GlcNAc...)Sequence analysis
Disulfide bondi339 ↔ 364PROSITE-ProRule annotation1 Publication
Disulfide bondi470 ↔ 522PROSITE-ProRule annotation1 Publication
Disulfide bondi471 ↔ 476PROSITE-ProRule annotation1 Publication
Glycosylationi505 – 5051N-linked (GlcNAc...)Sequence analysis
Disulfide bondi618 ↔ 693PROSITE-ProRule annotation
Modified residuei920 – 9201PhosphoserineCombined sources

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

EPDiQ9BXB1.
MaxQBiQ9BXB1.
PaxDbiQ9BXB1.
PRIDEiQ9BXB1.

PTM databases

iPTMnetiQ9BXB1.
PhosphoSiteiQ9BXB1.

Expressioni

Tissue specificityi

Expressed in multiple steroidogenic tissues: placenta, ovary, testis and adrenal. Expressed also in spinal cord, thyroid, stomach, trachea, heart, pancreas, kidney, prostate and spleen.

Gene expression databases

BgeeiQ9BXB1.
CleanExiHS_LGR4.
ExpressionAtlasiQ9BXB1. baseline and differential.
GenevisibleiQ9BXB1. HS.

Organism-specific databases

HPAiHPA030267.

Interactioni

Protein-protein interaction databases

BioGridi120644. 217 interactions.
DIPiDIP-59894N.
IntActiQ9BXB1. 1 interaction.
STRINGi9606.ENSP00000368516.

Structurei

Secondary structure

1
951
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi39 – 424Combined sources
Beta strandi61 – 633Combined sources
Turni74 – 796Combined sources
Beta strandi85 – 873Combined sources
Turni98 – 1036Combined sources
Beta strandi109 – 1113Combined sources
Turni122 – 1276Combined sources
Beta strandi133 – 1353Combined sources
Turni146 – 1516Combined sources
Beta strandi157 – 1593Combined sources
Helixi170 – 1734Combined sources
Beta strandi181 – 1833Combined sources
Turni194 – 1996Combined sources
Beta strandi205 – 2073Combined sources
Turni218 – 2236Combined sources
Beta strandi229 – 2313Combined sources
Helixi242 – 2465Combined sources
Beta strandi252 – 2543Combined sources
Turni265 – 2706Combined sources
Beta strandi276 – 2783Combined sources
Turni289 – 2946Combined sources
Beta strandi300 – 3045Combined sources
Beta strandi323 – 3297Combined sources
Helixi338 – 3414Combined sources
Turni342 – 3443Combined sources
Beta strandi347 – 3493Combined sources
Beta strandi369 – 3713Combined sources
Turni382 – 3876Combined sources
Beta strandi393 – 3953Combined sources
Turni406 – 4116Combined sources
Beta strandi417 – 4193Combined sources
Beta strandi437 – 4404Combined sources
Helixi453 – 4564Combined sources
Beta strandi461 – 4633Combined sources
Helixi467 – 4704Combined sources
Turni471 – 4733Combined sources
Beta strandi521 – 5233Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4KT1X-ray2.50A26-527[»]
4QXEX-ray2.20A27-396[»]
4QXFX-ray2.25A/B27-252[»]
ProteinModelPortaliQ9BXB1.
SMRiQ9BXB1. Positions 26-533, 540-809.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini25 – 5733LRRNTAdd
BLAST
Repeati58 – 7922LRR 1Add
BLAST
Repeati82 – 10322LRR 2Add
BLAST
Repeati106 – 12722LRR 3Add
BLAST
Repeati130 – 15122LRR 4Add
BLAST
Repeati154 – 17724LRR 5Add
BLAST
Repeati178 – 19922LRR 6Add
BLAST
Repeati202 – 22322LRR 7Add
BLAST
Repeati226 – 24722LRR 8Add
BLAST
Repeati249 – 27022LRR 9Add
BLAST
Repeati273 – 29422LRR 10Add
BLAST
Repeati320 – 34122LRR 11Add
BLAST
Repeati344 – 36522LRR 12Add
BLAST
Repeati366 – 38722LRR 13Add
BLAST
Repeati390 – 41122LRR 14Add
BLAST
Repeati414 – 43522LRR 15Add
BLAST

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation
Contains 15 LRR (leucine-rich) repeats.Curated
Contains 1 LRRNT domain.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
KOG2087. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00760000119088.
HOGENOMiHOG000231829.
HOVERGENiHBG031675.
InParanoidiQ9BXB1.
KOiK04309.
OMAiCSCDGDR.
OrthoDBiEOG7DNNTF.
PhylomeDBiQ9BXB1.
TreeFamiTF316814.

Family and domain databases

Gene3Di3.80.10.10. 3 hits.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR002131. Gphrmn_rcpt_fam.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRRNT.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
PF13855. LRR_8. 4 hits.
PF01462. LRRNT. 1 hit.
[Graphical view]
PRINTSiPR00373. GLYCHORMONER.
PR00237. GPCRRHODOPSN.
SMARTiSM00369. LRR_TYP. 15 hits.
SM00013. LRRNT. 1 hit.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 2 hits.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
PS51450. LRR. 15 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9BXB1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPGPLGLLCF LALGLLGSAG PSGAAPPLCA APCSCDGDRR VDCSGKGLTA
60 70 80 90 100
VPEGLSAFTQ ALDISMNNIT QLPEDAFKNF PFLEELQLAG NDLSFIHPKA
110 120 130 140 150
LSGLKELKVL TLQNNQLKTV PSEAIRGLSA LQSLRLDANH ITSVPEDSFE
160 170 180 190 200
GLVQLRHLWL DDNSLTEVPV HPLSNLPTLQ ALTLALNKIS SIPDFAFTNL
210 220 230 240 250
SSLVVLHLHN NKIRSLSQHC FDGLDNLETL DLNYNNLGEF PQAIKALPSL
260 270 280 290 300
KELGFHSNSI SVIPDGAFDG NPLLRTIHLY DNPLSFVGNS AFHNLSDLHS
310 320 330 340 350
LVIRGASMVQ QFPNLTGTVH LESLTLTGTK ISSIPNNLCQ EQKMLRTLDL
360 370 380 390 400
SYNNIRDLPS FNGCHALEEI SLQRNQIYQI KEGTFQGLIS LRILDLSRNL
410 420 430 440 450
IHEIHSRAFA TLGPITNLDV SFNELTSFPT EGLNGLNQLK LVGNFKLKEA
460 470 480 490 500
LAAKDFVNLR SLSVPYAYQC CAFWGCDSYA NLNTEDNSLQ DHSVAQEKGT
510 520 530 540 550
ADAANVTSTL ENEEHSQIII HCTPSTGAFK PCEYLLGSWM IRLTVWFIFL
560 570 580 590 600
VALFFNLLVI LTTFASCTSL PSSKLFIGLI SVSNLFMGIY TGILTFLDAV
610 620 630 640 650
SWGRFAEFGI WWETGSGCKV AGFLAVFSSE SAIFLLMLAT VERSLSAKDI
660 670 680 690 700
MKNGKSNHLK QFRVAALLAF LGATVAGCFP LFHRGEYSAS PLCLPFPTGE
710 720 730 740 750
TPSLGFTVTL VLLNSLAFLL MAVIYTKLYC NLEKEDLSEN SQSSMIKHVA
760 770 780 790 800
WLIFTNCIFF CPVAFFSFAP LITAISISPE IMKSVTLIFF PLPACLNPVL
810 820 830 840 850
YVFFNPKFKE DWKLLKRRVT KKSGSVSVSI SSQGGCLEQD FYYDCGMYSH
860 870 880 890 900
LQGNLTVCDC CESFLLTKPV SCKHLIKSHS CPALAVASCQ RPEGYWSDCG
910 920 930 940 950
TQSAHSDYAD EEDSFVSDSS DQVQACGRAC FYQSRGFPLV RYAYNLPRVK

D
Length:951
Mass (Da):104,475
Last modified:July 22, 2008 - v2
Checksum:i42D48AE5F0BEB6B1
GO
Isoform 2 (identifier: Q9BXB1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     62-85: Missing.

Show »
Length:927
Mass (Da):101,667
Checksum:i5046E961D4C693BB
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti22 – 221S → G in AAH33039 (PubMed:15489334).Curated
Sequence conflicti172 – 1721P → H in AAH33039 (PubMed:15489334).Curated
Sequence conflicti247 – 2471L → R in AAF68989 (PubMed:11401528).Curated
Sequence conflicti247 – 2471L → R in AAK31153 (PubMed:11401528).Curated
Sequence conflicti292 – 2921F → S in AAF68989 (PubMed:11401528).Curated
Sequence conflicti433 – 4331L → P in AAF68989 (PubMed:11401528).Curated
Sequence conflicti668 – 6681L → S in AAF68989 (PubMed:11401528).Curated
Sequence conflicti681 – 6811L → I in AAH33039 (PubMed:15489334).Curated

Polymorphismi

Genetic variations in LGR4 define the bone mineral density quantitative trait locus 17 (BMND17) [MIMi:615311]. Variance in bone mineral density influences bone mass, contributes to size determination in the general population, and is a susceptibility factor for osteoporotic fractures.1 Publication

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti215 – 2151S → G.1 Publication
Corresponds to variant rs2448010 [ dbSNP | Ensembl ].
VAR_044528
Natural varianti233 – 2331N → S.1 Publication
Corresponds to variant rs2472617 [ dbSNP | Ensembl ].
VAR_044529
Natural varianti480 – 4801A → V.
Corresponds to variant rs12284579 [ dbSNP | Ensembl ].
VAR_044530
Natural varianti684 – 6841R → G.
Corresponds to variant rs7125959 [ dbSNP | Ensembl ].
VAR_044531
Natural varianti709 – 7091T → M.
Corresponds to variant rs34717439 [ dbSNP | Ensembl ].
VAR_044532
Natural varianti844 – 8441D → G.
Corresponds to variant rs34804482 [ dbSNP | Ensembl ].
VAR_044533

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei62 – 8524Missing in isoform 2. 1 PublicationVSP_047136Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF346711, AF346709, AF346710 Genomic DNA. Translation: AAK31153.1.
AF257182 mRNA. Translation: AAF68989.1.
AC090597 Genomic DNA. No translation available.
AC100771 Genomic DNA. No translation available.
CH471064 Genomic DNA. Translation: EAW68285.1.
CH471064 Genomic DNA. Translation: EAW68286.1.
BC033039 mRNA. Translation: AAH33039.1.
CCDSiCCDS31449.1. [Q9BXB1-1]
RefSeqiNP_060960.2. NM_018490.2. [Q9BXB1-1]
UniGeneiHs.502176.

Genome annotation databases

EnsembliENST00000379214; ENSP00000368516; ENSG00000205213. [Q9BXB1-1]
ENST00000389858; ENSP00000374508; ENSG00000205213. [Q9BXB1-2]
GeneIDi55366.
KEGGihsa:55366.
UCSCiuc001mrj.5. human. [Q9BXB1-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF346711, AF346709, AF346710 Genomic DNA. Translation: AAK31153.1.
AF257182 mRNA. Translation: AAF68989.1.
AC090597 Genomic DNA. No translation available.
AC100771 Genomic DNA. No translation available.
CH471064 Genomic DNA. Translation: EAW68285.1.
CH471064 Genomic DNA. Translation: EAW68286.1.
BC033039 mRNA. Translation: AAH33039.1.
CCDSiCCDS31449.1. [Q9BXB1-1]
RefSeqiNP_060960.2. NM_018490.2. [Q9BXB1-1]
UniGeneiHs.502176.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4KT1X-ray2.50A26-527[»]
4QXEX-ray2.20A27-396[»]
4QXFX-ray2.25A/B27-252[»]
ProteinModelPortaliQ9BXB1.
SMRiQ9BXB1. Positions 26-533, 540-809.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120644. 217 interactions.
DIPiDIP-59894N.
IntActiQ9BXB1. 1 interaction.
STRINGi9606.ENSP00000368516.

Chemistry

GuidetoPHARMACOLOGYi147.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ9BXB1.
PhosphoSiteiQ9BXB1.

Polymorphism and mutation databases

BioMutaiLGR4.
DMDMi212286375.

Proteomic databases

EPDiQ9BXB1.
MaxQBiQ9BXB1.
PaxDbiQ9BXB1.
PRIDEiQ9BXB1.

Protocols and materials databases

DNASUi55366.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000379214; ENSP00000368516; ENSG00000205213. [Q9BXB1-1]
ENST00000389858; ENSP00000374508; ENSG00000205213. [Q9BXB1-2]
GeneIDi55366.
KEGGihsa:55366.
UCSCiuc001mrj.5. human. [Q9BXB1-1]

Organism-specific databases

CTDi55366.
GeneCardsiLGR4.
H-InvDBHIX0009517.
HGNCiHGNC:13299. LGR4.
HPAiHPA030267.
MalaCardsiLGR4.
MIMi166710. phenotype.
606666. gene.
615311. phenotype.
neXtProtiNX_Q9BXB1.
PharmGKBiPA28893.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
KOG2087. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00760000119088.
HOGENOMiHOG000231829.
HOVERGENiHBG031675.
InParanoidiQ9BXB1.
KOiK04309.
OMAiCSCDGDR.
OrthoDBiEOG7DNNTF.
PhylomeDBiQ9BXB1.
TreeFamiTF316814.

Enzyme and pathway databases

ReactomeiR-HSA-4641263. Regulation of FZD by ubiquitination.
SIGNORiQ9BXB1.

Miscellaneous databases

ChiTaRSiLGR4. human.
GeneWikiiLGR4.
GenomeRNAii55366.
PROiQ9BXB1.
SOURCEiSearch...

Gene expression databases

BgeeiQ9BXB1.
CleanExiHS_LGR4.
ExpressionAtlasiQ9BXB1. baseline and differential.
GenevisibleiQ9BXB1. HS.

Family and domain databases

Gene3Di3.80.10.10. 3 hits.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR002131. Gphrmn_rcpt_fam.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRRNT.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
PF13855. LRR_8. 4 hits.
PF01462. LRRNT. 1 hit.
[Graphical view]
PRINTSiPR00373. GLYCHORMONER.
PR00237. GPCRRHODOPSN.
SMARTiSM00369. LRR_TYP. 15 hits.
SM00013. LRRNT. 1 hit.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 2 hits.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
PS51450. LRR. 15 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular characterization of a novel glycoprotein hormone G-protein-coupled receptor."
    Loh E.D., Broussard S.R., Kolakowski L.F. Jr.
    Biochem. Biophys. Res. Commun. 282:757-764(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1), VARIANTS GLY-215 AND SER-233.
    Tissue: Pancreas.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Brain.
  5. "LGR4 and LGR5 are R-spondin receptors mediating Wnt/beta-catenin and Wnt/PCP signalling."
    Glinka A., Dolde C., Kirsch N., Huang Y.L., Kazanskaya O., Ingelfinger D., Boutros M., Cruciat C.M., Niehrs C.
    EMBO Rep. 12:1055-1061(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH RSPO1; RSPO2; RSPO3 AND RSPO4.
  6. Cited for: FUNCTION, INTERACTION WITH RSPO1; RSPO2; RSPO3 AND RSPO4.
  7. "R-spondins function as ligands of the orphan receptors LGR4 and LGR5 to regulate Wnt/beta-catenin signaling."
    Carmon K.S., Gong X., Lin Q., Thomas A., Liu Q.
    Proc. Natl. Acad. Sci. U.S.A. 108:11452-11457(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH RSPO1; RSPO2; RSPO3 AND RSPO4.
  8. Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH RSPO1.
  9. "Multi-functional norrin is a ligand for the LGR4 receptor."
    Deng C., Reddy P., Cheng Y., Luo C.W., Hsiao C.L., Hsueh A.J.
    J. Cell Sci. 126:2060-2068(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  10. Cited for: POLYMORPHISM, INVOLVEMENT IN OSTEOP, INVOLVEMENT IN BMND17.
  11. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-920, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  12. "Structural basis for R-spondin recognition by LGR4/5/6 receptors."
    Wang D., Huang B., Zhang S., Yu X., Wu W., Wang X.
    Genes Dev. 27:1339-1344(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) OF 26-527 IN COMPLEX WITH RSPO1, FUNCTION, GLYCOSYLATION AT ASN-68 AND ASN-199, DISULFIDE BONDS.

Entry informationi

Entry nameiLGR4_HUMAN
AccessioniPrimary (citable) accession number: Q9BXB1
Secondary accession number(s): A6NCH3
, G5E9B3, Q8N537, Q9NYD1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2002
Last sequence update: July 22, 2008
Last modified: June 8, 2016
This is version 134 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.