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Q9BXA6

- TSSK6_HUMAN

UniProt

Q9BXA6 - TSSK6_HUMAN

Protein

Testis-specific serine/threonine-protein kinase 6

Gene

TSSK6

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 114 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
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    Functioni

    Required for sperm production and function. Plays a role in DNA condensation during postmeiotic chromatin remodeling By similarity.By similarity

    Catalytic activityi

    ATP + a protein = ADP + a phosphoprotein.2 Publications

    Cofactori

    Magnesium.1 Publication

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei41 – 411ATP1 PublicationPROSITE-ProRule annotation
    Active sitei135 – 1351Proton acceptor1 PublicationPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi18 – 269ATPBy similarityPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB
    2. magnesium ion binding Source: UniProtKB
    3. protein binding Source: UniProtKB
    4. protein serine/threonine kinase activity Source: UniProtKB

    GO - Biological processi

    1. multicellular organismal development Source: UniProtKB-KW
    2. protein phosphorylation Source: UniProtKB
    3. sperm chromatin condensation Source: UniProtKB

    Keywords - Molecular functioni

    Developmental protein, Kinase, Serine/threonine-protein kinase, Transferase

    Keywords - Biological processi

    Differentiation, Spermatogenesis

    Keywords - Ligandi

    ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

    Enzyme and pathway databases

    BRENDAi2.7.11.1. 2681.
    SignaLinkiQ9BXA6.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Testis-specific serine/threonine-protein kinase 6 (EC:2.7.11.1)
    Short name:
    TSK-6
    Short name:
    TSSK-6
    Short name:
    Testis-specific kinase 6
    Alternative name(s):
    Cancer/testis antigen 72
    Short name:
    CT72
    Serine/threonine-protein kinase SSTK
    Small serine/threonine kinase
    Gene namesi
    Name:TSSK6Imported
    Synonyms:SSTKImported
    ORF Names:FKSG82
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:30410. TSSK6.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: UniProt

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi41 – 411K → M: Loss of kinase activity. Loss of binding to TSACC. 2 Publications
    Mutagenesisi135 – 1351D → N: Loss of kinase activity. No effect of binding to TSACC. 2 Publications

    Organism-specific databases

    PharmGKBiPA142670682.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 273273Testis-specific serine/threonine-protein kinase 6PRO_0000227746Add
    BLAST

    Post-translational modificationi

    Autophosphorylated.1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiQ9BXA6.
    PRIDEiQ9BXA6.

    PTM databases

    PhosphoSiteiQ9BXA6.

    Expressioni

    Tissue specificityi

    Highly expressed in testis. Expressed at lower levels in colon, small intestine, ovary, prostate, thymus, spleen and peripheral blood leukocytes.1 Publication

    Gene expression databases

    BgeeiQ9BXA6.
    CleanExiHS_TSSK6.
    GenevestigatoriQ9BXA6.

    Interactioni

    Subunit structurei

    Interacts with the heat shock proteins HSPCB, HSPA8 and HSPA1A. These interactions appear to be required for TSSK6 kinase activity. Interacts with TSACC; this interaction is direct and recruits TSACC to HSP90, which is essential for kinase activity.2 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    HSP90AB1P082383EBI-851883,EBI-352572

    Protein-protein interaction databases

    BioGridi123835. 9 interactions.
    IntActiQ9BXA6. 9 interactions.
    STRINGi9606.ENSP00000354168.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9BXA6.
    SMRiQ9BXA6. Positions 12-270.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini12 – 267256Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0515.
    HOGENOMiHOG000233016.
    HOVERGENiHBG101110.
    InParanoidiQ9BXA6.
    KOiK08811.
    OMAiVQRNGHI.
    OrthoDBiEOG7P8P8F.
    PhylomeDBiQ9BXA6.
    TreeFamiTF105333.

    Family and domain databases

    InterProiIPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view]
    PfamiPF00069. Pkinase. 1 hit.
    [Graphical view]
    SMARTiSM00220. S_TKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9BXA6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSGDKLLSEL GYKLGRTIGE GSYSKVKVAT SKKYKGTVAI KVVDRRRAPP    50
    DFVNKFLPRE LSILRGVRHP HIVHVFEFIE VCNGKLYIVM EAAATDLLQA 100
    VQRNGRIPGV QARDLFAQIA GAVRYLHDHH LVHRDLKCEN VLLSPDERRV 150
    KLTDFGFGRQ AHGYPDLSTT YCGSAAYASP EVLLGIPYDP KKYDVWSMGV 200
    VLYVMVTGCM PFDDSDIAGL PRRQKRGVLY PEGLELSERC KALIAELLQF 250
    SPSARPSAGQ VARNCWLRAG DSG 273
    Length:273
    Mass (Da):30,331
    Last modified:June 1, 2001 - v1
    Checksum:i998934C72963C7CE
    GO

    Sequence cautioni

    The sequence BAB71697.1 differs from that shown. Reason: Frameshift at positions 104 and 169.
    The sequence BAD18805.1 differs from that shown. Reason: Frameshift at position 247.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF329483 mRNA. Translation: AAK48827.1.
    AF348077 mRNA. Translation: AAK29414.1.
    AK058166 mRNA. Translation: BAB71697.1. Frameshift.
    AK172841 mRNA. Translation: BAD18805.1. Frameshift.
    AK313767 mRNA. Translation: BAG36505.1.
    CH471106 Genomic DNA. Translation: EAW84824.1.
    BC014611 mRNA. Translation: AAH14611.1.
    CCDSiCCDS12403.1.
    RefSeqiNP_114426.1. NM_032037.3.
    UniGeneiHs.532711.
    Hs.666780.

    Genome annotation databases

    EnsembliENST00000585580; ENSP00000466477; ENSG00000178093.
    ENST00000587522; ENSP00000466056; ENSG00000178093.
    GeneIDi83983.
    KEGGihsa:83983.
    UCSCiuc002nmr.3. human.

    Polymorphism databases

    DMDMi74761315.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF329483 mRNA. Translation: AAK48827.1 .
    AF348077 mRNA. Translation: AAK29414.1 .
    AK058166 mRNA. Translation: BAB71697.1 . Frameshift.
    AK172841 mRNA. Translation: BAD18805.1 . Frameshift.
    AK313767 mRNA. Translation: BAG36505.1 .
    CH471106 Genomic DNA. Translation: EAW84824.1 .
    BC014611 mRNA. Translation: AAH14611.1 .
    CCDSi CCDS12403.1.
    RefSeqi NP_114426.1. NM_032037.3.
    UniGenei Hs.532711.
    Hs.666780.

    3D structure databases

    ProteinModelPortali Q9BXA6.
    SMRi Q9BXA6. Positions 12-270.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 123835. 9 interactions.
    IntActi Q9BXA6. 9 interactions.
    STRINGi 9606.ENSP00000354168.

    PTM databases

    PhosphoSitei Q9BXA6.

    Polymorphism databases

    DMDMi 74761315.

    Proteomic databases

    PaxDbi Q9BXA6.
    PRIDEi Q9BXA6.

    Protocols and materials databases

    DNASUi 83983.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000585580 ; ENSP00000466477 ; ENSG00000178093 .
    ENST00000587522 ; ENSP00000466056 ; ENSG00000178093 .
    GeneIDi 83983.
    KEGGi hsa:83983.
    UCSCi uc002nmr.3. human.

    Organism-specific databases

    CTDi 83983.
    GeneCardsi GC19M019623.
    H-InvDB HIX0174374.
    HGNCi HGNC:30410. TSSK6.
    MIMi 610712. gene.
    neXtProti NX_Q9BXA6.
    PharmGKBi PA142670682.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0515.
    HOGENOMi HOG000233016.
    HOVERGENi HBG101110.
    InParanoidi Q9BXA6.
    KOi K08811.
    OMAi VQRNGHI.
    OrthoDBi EOG7P8P8F.
    PhylomeDBi Q9BXA6.
    TreeFami TF105333.

    Enzyme and pathway databases

    BRENDAi 2.7.11.1. 2681.
    SignaLinki Q9BXA6.

    Miscellaneous databases

    GenomeRNAii 83983.
    NextBioi 73110.
    PROi Q9BXA6.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9BXA6.
    CleanExi HS_TSSK6.
    Genevestigatori Q9BXA6.

    Family and domain databases

    InterProi IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view ]
    Pfami PF00069. Pkinase. 1 hit.
    [Graphical view ]
    SMARTi SM00220. S_TKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification and characterization of SSTK, a serine/threonine protein kinase essential for male fertility."
      Spiridonov N.A., Wong L., Zerfas P.M., Starost M.F., Pack S.D., Paweletz C.P., Johnson G.R.
      Mol. Cell. Biol. 25:4250-4261(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, INTERACTION WITH HSPCB; HSPA8 AND HSPA1A, AUTOPHOSPHORYLATION, MUTAGENESIS OF LYS-41 AND ASP-135.
    2. "Identification of FKSG82, a novel gene located on human chromosome 19."
      Wang Y.-G., Gong L.
      Submitted (FEB-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Ileal mucosaImported and TestisImported.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: TestisImported.
    6. "Identification of a novel HSP70-binding cochaperone critical to HSP90-mediated activation of small serine/threonine kinase."
      Jha K.N., Wong L., Zerfas P.M., De Silva R.S., Fan Y.X., Spiridonov N.A., Johnson G.R.
      J. Biol. Chem. 285:35180-35187(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: CATALYTIC ACTIVITY, INTERACTION WITH TSACC, MUTAGENESIS OF LYS-41 AND ASP-135.

    Entry informationi

    Entry nameiTSSK6_HUMAN
    AccessioniPrimary (citable) accession number: Q9BXA6
    Secondary accession number(s): B2R9F8, Q6ZMC4, Q96LJ4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 21, 2006
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 114 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. Human and mouse protein kinases
      Human and mouse protein kinases: classification and index
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3