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Protein

Succinate receptor 1

Gene

SUCNR1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Receptor for succinate.1 Publication

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-HSA-373076. Class A/1 (Rhodopsin-like receptors).
R-HSA-418594. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Succinate receptor 1
Alternative name(s):
G-protein coupled receptor 91
P2Y purinoceptor 1-like
Gene namesi
Name:SUCNR1
Synonyms:GPR91
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:4542. SUCNR1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini5 – 3127ExtracellularSequence analysisAdd
BLAST
Transmembranei32 – 5221Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini53 – 597CytoplasmicSequence analysis
Transmembranei60 – 8021Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini81 – 10323ExtracellularSequence analysisAdd
BLAST
Transmembranei104 – 12421Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini125 – 13713CytoplasmicSequence analysisAdd
BLAST
Transmembranei138 – 15821Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini159 – 18527ExtracellularSequence analysisAdd
BLAST
Transmembranei186 – 20621Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini207 – 23024CytoplasmicSequence analysisAdd
BLAST
Transmembranei231 – 25121Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini252 – 28130ExtracellularSequence analysisAdd
BLAST
Transmembranei282 – 30221Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini303 – 33432CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi99 – 991R → A: Abolishes activation by succinate. 1 Publication
Mutagenesisi103 – 1031H → A: Abolishes activation by succinate. 1 Publication
Mutagenesisi107 – 1071Y → F: No effect on receptor function. 1 Publication
Mutagenesisi249 – 2491H → A: No effect on receptor function. 1 Publication
Mutagenesisi252 – 2521R → A: Abolishes activation by succinate. 1 Publication
Mutagenesisi255 – 2551R → A: No effect on receptor function. 1 Publication
Mutagenesisi281 – 2811R → A: Abolishes activation by succinate. 1 Publication

Organism-specific databases

PharmGKBiPA28934.

Chemistry

ChEMBLiCHEMBL2150838.
DrugBankiDB00139. Succinic acid.
GuidetoPHARMACOLOGYi166.

Polymorphism and mutation databases

BioMutaiSUCNR1.
DMDMi259016146.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 334334Succinate receptor 1PRO_0000070134Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi8 – 81N-linked (GlcNAc...)Sequence analysis
Disulfide bondi95 ↔ 172PROSITE-ProRule annotation
Glycosylationi168 – 1681N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9BXA5.
PRIDEiQ9BXA5.

Expressioni

Tissue specificityi

Expressed specifically in kidney.1 Publication

Gene expression databases

BgeeiQ9BXA5.
CleanExiHS_SUCNR1.
GenevisibleiQ9BXA5. HS.

Organism-specific databases

HPAiCAB022745.

Interactioni

Protein-protein interaction databases

BioGridi121179. 1 interaction.
STRINGi9606.ENSP00000355156.

Chemistry

BindingDBiQ9BXA5.

Structurei

3D structure databases

ProteinModelPortaliQ9BXA5.
SMRiQ9BXA5. Positions 18-303.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJKI. Eukaryota.
ENOG410YANU. LUCA.
GeneTreeiENSGT00760000118784.
HOGENOMiHOG000231307.
HOVERGENiHBG095590.
InParanoidiQ9BXA5.
KOiK10042.
OMAiCTLPMLI.
OrthoDBiEOG7QRQV4.
PhylomeDBiQ9BXA5.
TreeFamiTF350009.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9BXA5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLGIMAWNAT CKNWLAAEAA LEKYYLSIFY GIEFVVGVLG NTIVVYGYIF
60 70 80 90 100
SLKNWNSSNI YLFNLSVSDL AFLCTLPMLI RSYANGNWIY GDVLCISNRY
110 120 130 140 150
VLHANLYTSI LFLTFISIDR YLIIKYPFRE HLLQKKEFAI LISLAIWVLV
160 170 180 190 200
TLELLPILPL INPVITDNGT TCNDFASSGD PNYNLIYSMC LTLLGFLIPL
210 220 230 240 250
FVMCFFYYKI ALFLKQRNRQ VATALPLEKP LNLVIMAVVI FSVLFTPYHV
260 270 280 290 300
MRNVRIASRL GSWKQYQCTQ VVINSFYIVT RPLAFLNSVI NPVFYFLLGD
310 320 330
HFRDMLMNQL RHNFKSLTSF SRWAHELLLS FREK
Length:334
Mass (Da):38,698
Last modified:September 22, 2009 - v2
Checksum:i33146E1AD87F0E81
GO

Sequence cautioni

The sequence AAK29080.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF348078 mRNA. Translation: AAK29080.1. Different initiation.
AF247785 mRNA. Translation: AAL95690.1.
EU432110 mRNA. Translation: ABY87909.1.
AK290420 mRNA. Translation: BAF83109.1.
AC068647 Genomic DNA. No translation available.
CH471052 Genomic DNA. Translation: EAW78789.1.
BC030948 mRNA. Translation: AAH30948.3.
CCDSiCCDS3162.1.
RefSeqiNP_149039.2. NM_033050.4.
UniGeneiHs.279575.

Genome annotation databases

EnsembliENST00000362032; ENSP00000355156; ENSG00000198829.
GeneIDi56670.
KEGGihsa:56670.
UCSCiuc003ezf.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF348078 mRNA. Translation: AAK29080.1. Different initiation.
AF247785 mRNA. Translation: AAL95690.1.
EU432110 mRNA. Translation: ABY87909.1.
AK290420 mRNA. Translation: BAF83109.1.
AC068647 Genomic DNA. No translation available.
CH471052 Genomic DNA. Translation: EAW78789.1.
BC030948 mRNA. Translation: AAH30948.3.
CCDSiCCDS3162.1.
RefSeqiNP_149039.2. NM_033050.4.
UniGeneiHs.279575.

3D structure databases

ProteinModelPortaliQ9BXA5.
SMRiQ9BXA5. Positions 18-303.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121179. 1 interaction.
STRINGi9606.ENSP00000355156.

Chemistry

BindingDBiQ9BXA5.
ChEMBLiCHEMBL2150838.
DrugBankiDB00139. Succinic acid.
GuidetoPHARMACOLOGYi166.

Protein family/group databases

GPCRDBiSearch...

Polymorphism and mutation databases

BioMutaiSUCNR1.
DMDMi259016146.

Proteomic databases

PaxDbiQ9BXA5.
PRIDEiQ9BXA5.

Protocols and materials databases

DNASUi56670.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000362032; ENSP00000355156; ENSG00000198829.
GeneIDi56670.
KEGGihsa:56670.
UCSCiuc003ezf.3. human.

Organism-specific databases

CTDi56670.
GeneCardsiSUCNR1.
HGNCiHGNC:4542. SUCNR1.
HPAiCAB022745.
MIMi606381. gene.
neXtProtiNX_Q9BXA5.
PharmGKBiPA28934.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IJKI. Eukaryota.
ENOG410YANU. LUCA.
GeneTreeiENSGT00760000118784.
HOGENOMiHOG000231307.
HOVERGENiHBG095590.
InParanoidiQ9BXA5.
KOiK10042.
OMAiCTLPMLI.
OrthoDBiEOG7QRQV4.
PhylomeDBiQ9BXA5.
TreeFamiTF350009.

Enzyme and pathway databases

ReactomeiR-HSA-373076. Class A/1 (Rhodopsin-like receptors).
R-HSA-418594. G alpha (i) signalling events.

Miscellaneous databases

GeneWikiiSUCNR1.
GenomeRNAii56670.
PROiQ9BXA5.
SOURCEiSearch...

Gene expression databases

BgeeiQ9BXA5.
CleanExiHS_SUCNR1.
GenevisibleiQ9BXA5. HS.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "An expressed sequence tag (EST) data mining strategy succeeding in the discovery of new G-protein coupled receptors."
    Wittenberger T., Schaller H.C., Hellebrand S.
    J. Mol. Biol. 307:799-813(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
  2. "Human P2Y purinoceptor 1."
    Zhang W., Li N., Wan T., Cao X.
    Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. Kaighin V.A., Martin A.L., Aronstam R.S.
    Submitted (DEC-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Kidney.
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Umbilical cord blood.
  5. "The DNA sequence, annotation and analysis of human chromosome 3."
    Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
    , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
    Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney.
  8. "Citric acid cycle intermediates as ligands for orphan G-protein-coupled receptors."
    He W., Miao F.J.-P., Lin D.C.-H., Schwandner R.T., Wang Z., Gao J., Chen J.-L., Tian H., Ling L.
    Nature 429:188-193(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, MUTAGENESIS OF ARG-99; HIS-103; TYR-107; HIS-249; ARG-252; ARG-255 AND ARG-281, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiSUCR1_HUMAN
AccessioniPrimary (citable) accession number: Q9BXA5
Secondary accession number(s): A8K305, Q8TDQ8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: September 22, 2009
Last modified: June 8, 2016
This is version 118 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-5 is the initiator.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.