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Protein

Succinate receptor 1

Gene

SUCNR1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Receptor for succinate.1 Publication

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

BioCyciZFISH:G66-31602-MONOMER.
ReactomeiR-HSA-373076. Class A/1 (Rhodopsin-like receptors).
R-HSA-418594. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Succinate receptor 1
Alternative name(s):
G-protein coupled receptor 91
P2Y purinoceptor 1-like
Gene namesi
Name:SUCNR1
Synonyms:GPR91
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:4542. SUCNR1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini5 – 31ExtracellularSequence analysisAdd BLAST27
Transmembranei32 – 52Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini53 – 59CytoplasmicSequence analysis7
Transmembranei60 – 80Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini81 – 103ExtracellularSequence analysisAdd BLAST23
Transmembranei104 – 124Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini125 – 137CytoplasmicSequence analysisAdd BLAST13
Transmembranei138 – 158Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini159 – 185ExtracellularSequence analysisAdd BLAST27
Transmembranei186 – 206Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini207 – 230CytoplasmicSequence analysisAdd BLAST24
Transmembranei231 – 251Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini252 – 281ExtracellularSequence analysisAdd BLAST30
Transmembranei282 – 302Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini303 – 334CytoplasmicSequence analysisAdd BLAST32

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi99R → A: Abolishes activation by succinate. 1 Publication1
Mutagenesisi103H → A: Abolishes activation by succinate. 1 Publication1
Mutagenesisi107Y → F: No effect on receptor function. 1 Publication1
Mutagenesisi249H → A: No effect on receptor function. 1 Publication1
Mutagenesisi252R → A: Abolishes activation by succinate. 1 Publication1
Mutagenesisi255R → A: No effect on receptor function. 1 Publication1
Mutagenesisi281R → A: Abolishes activation by succinate. 1 Publication1

Organism-specific databases

DisGeNETi56670.
OpenTargetsiENSG00000198829.
PharmGKBiPA28934.

Chemistry databases

ChEMBLiCHEMBL2150838.
DrugBankiDB00139. Succinic acid.
GuidetoPHARMACOLOGYi166.

Polymorphism and mutation databases

BioMutaiSUCNR1.
DMDMi259016146.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000701341 – 334Succinate receptor 1Add BLAST334

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi8N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi95 ↔ 172PROSITE-ProRule annotation
Glycosylationi168N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9BXA5.
PeptideAtlasiQ9BXA5.
PRIDEiQ9BXA5.

PTM databases

PhosphoSitePlusiQ9BXA5.

Expressioni

Tissue specificityi

Expressed specifically in kidney.1 Publication

Gene expression databases

BgeeiENSG00000198829.
CleanExiHS_SUCNR1.
GenevisibleiQ9BXA5. HS.

Organism-specific databases

HPAiCAB022745.

Interactioni

Protein-protein interaction databases

BioGridi121179. 1 interactor.
STRINGi9606.ENSP00000355156.

Chemistry databases

BindingDBiQ9BXA5.

Structurei

3D structure databases

ProteinModelPortaliQ9BXA5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJKI. Eukaryota.
ENOG410YANU. LUCA.
GeneTreeiENSGT00760000118784.
HOGENOMiHOG000231307.
HOVERGENiHBG095590.
InParanoidiQ9BXA5.
KOiK10042.
OMAiCTLPMLI.
OrthoDBiEOG091G0FDD.
PhylomeDBiQ9BXA5.
TreeFamiTF350009.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9BXA5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLGIMAWNAT CKNWLAAEAA LEKYYLSIFY GIEFVVGVLG NTIVVYGYIF
60 70 80 90 100
SLKNWNSSNI YLFNLSVSDL AFLCTLPMLI RSYANGNWIY GDVLCISNRY
110 120 130 140 150
VLHANLYTSI LFLTFISIDR YLIIKYPFRE HLLQKKEFAI LISLAIWVLV
160 170 180 190 200
TLELLPILPL INPVITDNGT TCNDFASSGD PNYNLIYSMC LTLLGFLIPL
210 220 230 240 250
FVMCFFYYKI ALFLKQRNRQ VATALPLEKP LNLVIMAVVI FSVLFTPYHV
260 270 280 290 300
MRNVRIASRL GSWKQYQCTQ VVINSFYIVT RPLAFLNSVI NPVFYFLLGD
310 320 330
HFRDMLMNQL RHNFKSLTSF SRWAHELLLS FREK
Length:334
Mass (Da):38,698
Last modified:September 22, 2009 - v2
Checksum:i33146E1AD87F0E81
GO

Sequence cautioni

The sequence AAK29080 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF348078 mRNA. Translation: AAK29080.1. Different initiation.
AF247785 mRNA. Translation: AAL95690.1.
EU432110 mRNA. Translation: ABY87909.1.
AK290420 mRNA. Translation: BAF83109.1.
AC068647 Genomic DNA. No translation available.
CH471052 Genomic DNA. Translation: EAW78789.1.
BC030948 mRNA. Translation: AAH30948.3.
CCDSiCCDS3162.1.
RefSeqiNP_149039.2. NM_033050.5.
UniGeneiHs.133181.
Hs.279575.
Hs.627102.

Genome annotation databases

EnsembliENST00000362032; ENSP00000355156; ENSG00000198829.
GeneIDi56670.
KEGGihsa:56670.
UCSCiuc003ezf.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF348078 mRNA. Translation: AAK29080.1. Different initiation.
AF247785 mRNA. Translation: AAL95690.1.
EU432110 mRNA. Translation: ABY87909.1.
AK290420 mRNA. Translation: BAF83109.1.
AC068647 Genomic DNA. No translation available.
CH471052 Genomic DNA. Translation: EAW78789.1.
BC030948 mRNA. Translation: AAH30948.3.
CCDSiCCDS3162.1.
RefSeqiNP_149039.2. NM_033050.5.
UniGeneiHs.133181.
Hs.279575.
Hs.627102.

3D structure databases

ProteinModelPortaliQ9BXA5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121179. 1 interactor.
STRINGi9606.ENSP00000355156.

Chemistry databases

BindingDBiQ9BXA5.
ChEMBLiCHEMBL2150838.
DrugBankiDB00139. Succinic acid.
GuidetoPHARMACOLOGYi166.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSitePlusiQ9BXA5.

Polymorphism and mutation databases

BioMutaiSUCNR1.
DMDMi259016146.

Proteomic databases

PaxDbiQ9BXA5.
PeptideAtlasiQ9BXA5.
PRIDEiQ9BXA5.

Protocols and materials databases

DNASUi56670.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000362032; ENSP00000355156; ENSG00000198829.
GeneIDi56670.
KEGGihsa:56670.
UCSCiuc003ezf.3. human.

Organism-specific databases

CTDi56670.
DisGeNETi56670.
GeneCardsiSUCNR1.
HGNCiHGNC:4542. SUCNR1.
HPAiCAB022745.
MIMi606381. gene.
neXtProtiNX_Q9BXA5.
OpenTargetsiENSG00000198829.
PharmGKBiPA28934.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IJKI. Eukaryota.
ENOG410YANU. LUCA.
GeneTreeiENSGT00760000118784.
HOGENOMiHOG000231307.
HOVERGENiHBG095590.
InParanoidiQ9BXA5.
KOiK10042.
OMAiCTLPMLI.
OrthoDBiEOG091G0FDD.
PhylomeDBiQ9BXA5.
TreeFamiTF350009.

Enzyme and pathway databases

BioCyciZFISH:G66-31602-MONOMER.
ReactomeiR-HSA-373076. Class A/1 (Rhodopsin-like receptors).
R-HSA-418594. G alpha (i) signalling events.

Miscellaneous databases

GeneWikiiSUCNR1.
GenomeRNAii56670.
PROiQ9BXA5.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000198829.
CleanExiHS_SUCNR1.
GenevisibleiQ9BXA5. HS.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSUCR1_HUMAN
AccessioniPrimary (citable) accession number: Q9BXA5
Secondary accession number(s): A8K305, Q8TDQ8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: September 22, 2009
Last modified: November 2, 2016
This is version 122 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-5 is the initiator.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.