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Protein

Plasmalemma vesicle-associated protein

Gene

PLVAP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Involved in the formation of stomatal and fenestral diaphragms of caveolae. May function in microvascular permeability.1 Publication

GO - Biological processi

  • MAPK cascade Source: UniProtKB
  • positive regulation of cellular extravasation Source: UniProtKB
  • tumor necrosis factor-mediated signaling pathway Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Plasmalemma vesicle-associated protein
Alternative name(s):
Fenestrated endothelial-linked structure protein
Plasmalemma vesicle protein 1
Short name:
PV-1
Gene namesi
Name:PLVAP
Synonyms:FELS, PV1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:13635. PLVAP.

Subcellular locationi

  • Cell membrane By similarity; Single-pass type II membrane protein Sequence analysis
  • Membranecaveola By similarity; Single-pass type II membrane protein Sequence analysis
  • Cytoplasmperinuclear region By similarity

  • Note: Membrane-associated protein of caveolae. Found in fenestral and stomatal diaphragms in fenestrated endothelia and transendothelial channels. Also colocalized with CAV1 in perinuclear region.By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2727CytoplasmicSequence analysisAdd
BLAST
Transmembranei28 – 4821Helical; Signal-anchor for type II membrane proteinSequence analysisAdd
BLAST
Topological domaini49 – 442394ExtracellularSequence analysisAdd
BLAST

GO - Cellular componenti

  • caveola Source: UniProtKB
  • cell surface Source: UniProtKB
  • extracellular exosome Source: UniProtKB
  • integral component of membrane Source: UniProtKB-KW
  • perinuclear region of cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA33424.

Polymorphism and mutation databases

BioMutaiPLVAP.
DMDMi73921753.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 442442Plasmalemma vesicle-associated proteinPRO_0000058462Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi83 – 831N-linked (GlcNAc...)Sequence analysis
Glycosylationi89 – 891N-linked (GlcNAc...)Sequence analysis
Glycosylationi113 – 1131N-linked (GlcNAc...)Sequence analysis
Glycosylationi151 – 1511N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9BX97.
PRIDEiQ9BX97.

PTM databases

PhosphoSiteiQ9BX97.

Expressioni

Tissue specificityi

Expressed in lung, kidney, heart, aorta, placenta, muscle, pituitary gland, adrenals, mammary gland, bladder, lymph node, bone marrow, trachea, digestive tract, liver and tumor-associated endothelium.2 Publications

Inductioni

By phorbol myristate acetate (PMA) or VEGF in endothelial cell culture.2 Publications

Gene expression databases

BgeeiQ9BX97.
CleanExiHS_PLVAP.
ExpressionAtlasiQ9BX97. baseline and differential.
GenevisibleiQ9BX97. HS.

Organism-specific databases

HPAiHPA002279.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

BioGridi123668. 8 interactions.
IntActiQ9BX97. 8 interactions.
STRINGi9606.ENSP00000252590.

Structurei

3D structure databases

ProteinModelPortaliQ9BX97.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili57 – 7721Sequence analysisAdd
BLAST
Coiled coili202 – 22524Sequence analysisAdd
BLAST
Coiled coili280 – 387108Sequence analysisAdd
BLAST

Keywords - Domaini

Coiled coil, Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJNT. Eukaryota.
ENOG410Y4AG. LUCA.
GeneTreeiENSGT00390000006166.
HOGENOMiHOG000115581.
HOVERGENiHBG082152.
InParanoidiQ9BX97.
KOiK17309.
OMAiMGLAMEH.
OrthoDBiEOG7PCJH0.
PhylomeDBiQ9BX97.
TreeFamiTF337332.

Family and domain databases

InterProiIPR009538. PV-1.
[Graphical view]
PfamiPF06637. PV-1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9BX97-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGLAMEHGGS YARAGGSSRG CWYYLRYFFL FVSLIQFLII LGLVLFMVYG
60 70 80 90 100
NVHVSTESNL QATERRAEGL YSQLLGLTAS QSNLTKELNF TTRAKDAIMQ
110 120 130 140 150
MWLNARRDLD RINASFRQCQ GDRVIYTNNQ RYMAAIILSE KQCRDQFKDM
160 170 180 190 200
NKSCDALLFM LNQKVKTLEV EIAKEKTICT KDKESVLLNK RVAEEQLVEC
210 220 230 240 250
VKTRELQHQE RQLAKEQLQK VQALCLPLDK DKFEMDLRNL WRDSIIPRSL
260 270 280 290 300
DNLGYNLYHP LGSELASIRR ACDHMPSLMS SKVEELARSL RADIERVARE
310 320 330 340 350
NSDLQRQKLE AQQGLRASQE AKQKVEKEAQ AREAKLQAEC SRQTQLALEE
360 370 380 390 400
KAVLRKERDN LAKELEEKKR EAEQLRMELA IRNSALDTCI KTKSQPMMPV
410 420 430 440
SRPMGPVPNP QPIDPASLEE FKRKILESQR PPAGIPVAPS SG
Length:442
Mass (Da):50,594
Last modified:June 1, 2001 - v1
Checksum:iD89ADBC9309A46FA
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti130 – 1301Q → H in AAK11226 (Ref. 2) Curated
Sequence conflicti328 – 3325Missing in BAC04681 (PubMed:14702039).Curated
Sequence conflicti439 – 4391P → L in BAC04681 (PubMed:14702039).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF348827 mRNA. Translation: AAK20040.1.
AF326591 mRNA. Translation: AAK11226.1.
AK074054 mRNA. Translation: BAB84880.1.
AK096030 mRNA. Translation: BAC04681.1.
AL834363 mRNA. Translation: CAD39027.2.
BC050365 mRNA. Translation: AAH50365.2.
BC056414 mRNA. Translation: AAH56414.1.
CCDSiCCDS32952.1.
RefSeqiNP_112600.1. NM_031310.2.
UniGeneiHs.107125.

Genome annotation databases

EnsembliENST00000252590; ENSP00000252590; ENSG00000130300.
GeneIDi83483.
KEGGihsa:83483.
UCSCiuc002ngk.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF348827 mRNA. Translation: AAK20040.1.
AF326591 mRNA. Translation: AAK11226.1.
AK074054 mRNA. Translation: BAB84880.1.
AK096030 mRNA. Translation: BAC04681.1.
AL834363 mRNA. Translation: CAD39027.2.
BC050365 mRNA. Translation: AAH50365.2.
BC056414 mRNA. Translation: AAH56414.1.
CCDSiCCDS32952.1.
RefSeqiNP_112600.1. NM_031310.2.
UniGeneiHs.107125.

3D structure databases

ProteinModelPortaliQ9BX97.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123668. 8 interactions.
IntActiQ9BX97. 8 interactions.
STRINGi9606.ENSP00000252590.

PTM databases

PhosphoSiteiQ9BX97.

Polymorphism and mutation databases

BioMutaiPLVAP.
DMDMi73921753.

Proteomic databases

PaxDbiQ9BX97.
PRIDEiQ9BX97.

Protocols and materials databases

DNASUi83483.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000252590; ENSP00000252590; ENSG00000130300.
GeneIDi83483.
KEGGihsa:83483.
UCSCiuc002ngk.2. human.

Organism-specific databases

CTDi83483.
GeneCardsiPLVAP.
HGNCiHGNC:13635. PLVAP.
HPAiHPA002279.
MIMi607647. gene.
neXtProtiNX_Q9BX97.
PharmGKBiPA33424.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IJNT. Eukaryota.
ENOG410Y4AG. LUCA.
GeneTreeiENSGT00390000006166.
HOGENOMiHOG000115581.
HOVERGENiHBG082152.
InParanoidiQ9BX97.
KOiK17309.
OMAiMGLAMEH.
OrthoDBiEOG7PCJH0.
PhylomeDBiQ9BX97.
TreeFamiTF337332.

Miscellaneous databases

GeneWikiiPLVAP.
GenomeRNAii83483.
NextBioi72439.
PROiQ9BX97.
SOURCEiSearch...

Gene expression databases

BgeeiQ9BX97.
CleanExiHS_PLVAP.
ExpressionAtlasiQ9BX97. baseline and differential.
GenevisibleiQ9BX97. HS.

Family and domain databases

InterProiIPR009538. PV-1.
[Graphical view]
PfamiPF06637. PV-1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "cDNA and protein sequence, genomic organization, and analysis of cis regulatory elements of mouse and human PLVAP genes."
    Stan R.-V., Arden K.C., Palade G.E.
    Genomics 72:304-313(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
  2. Mesak F.M., Schoecklmann H., Hallmann R.
    Submitted (DEC-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney and Spleen.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lymph node.
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: PNS.
  6. "PV1 is a key structural component for the formation of the stomatal and fenestral diaphragms."
    Stan R.-V., Tkachenko E., Niesman I.R.
    Mol. Biol. Cell 15:3615-3630(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INDUCTION.
  7. "Plasmalemmal vesicle-associated protein (PLVAP) is expressed by tumour endothelium and is upregulated by vascular endothelial growth factor-A (VEGF)."
    Strickland L.A., Jubb A.M., Hongo J.-A., Zhong F., Burwick J., Fu L., Frantz G.D., Koeppen H.
    J. Pathol. 206:466-475(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION, TISSUE SPECIFICITY.

Entry informationi

Entry nameiPLVAP_HUMAN
AccessioniPrimary (citable) accession number: Q9BX97
Secondary accession number(s): Q86VP0
, Q8N8Y0, Q8ND68, Q8TER8, Q9BZD5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: June 1, 2001
Last modified: March 16, 2016
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.