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Protein

Plasmalemma vesicle-associated protein

Gene

PLVAP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Involved in the formation of stomatal and fenestral diaphragms of caveolae. May function in microvascular permeability.1 Publication

GO - Molecular functioni

GO - Biological processi

  • MAPK cascade Source: UniProtKB
  • positive regulation of cellular extravasation Source: UniProtKB
  • tumor necrosis factor-mediated signaling pathway Source: UniProtKB

Names & Taxonomyi

Protein namesi
Recommended name:
Plasmalemma vesicle-associated protein
Alternative name(s):
Fenestrated endothelial-linked structure protein
Plasmalemma vesicle protein 1
Short name:
PV-1
Gene namesi
Name:PLVAP
Synonyms:FELS, PV1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000130300.8.
HGNCiHGNC:13635. PLVAP.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 27CytoplasmicSequence analysisAdd BLAST27
Transmembranei28 – 48Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini49 – 442ExtracellularSequence analysisAdd BLAST394

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi83483.
OpenTargetsiENSG00000130300.
PharmGKBiPA33424.

Polymorphism and mutation databases

BioMutaiPLVAP.
DMDMi73921753.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000584621 – 442Plasmalemma vesicle-associated proteinAdd BLAST442

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi83N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi89N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi113N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi151N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ9BX97.
PaxDbiQ9BX97.
PeptideAtlasiQ9BX97.
PRIDEiQ9BX97.

PTM databases

iPTMnetiQ9BX97.
PhosphoSitePlusiQ9BX97.

Expressioni

Tissue specificityi

Expressed in lung, kidney, heart, aorta, placenta, muscle, pituitary gland, adrenals, mammary gland, bladder, lymph node, bone marrow, trachea, digestive tract, liver and tumor-associated endothelium.2 Publications

Inductioni

By phorbol myristate acetate (PMA) or VEGF in endothelial cell culture.2 Publications

Gene expression databases

BgeeiENSG00000130300.
CleanExiHS_PLVAP.
ExpressionAtlasiQ9BX97. baseline and differential.
GenevisibleiQ9BX97. HS.

Organism-specific databases

HPAiHPA002279.

Interactioni

Subunit structurei

Homodimer.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi123668. 9 interactors.
IntActiQ9BX97. 9 interactors.
STRINGi9606.ENSP00000252590.

Structurei

3D structure databases

ProteinModelPortaliQ9BX97.
SMRiQ9BX97.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili57 – 77Sequence analysisAdd BLAST21
Coiled coili202 – 225Sequence analysisAdd BLAST24
Coiled coili280 – 387Sequence analysisAdd BLAST108

Keywords - Domaini

Coiled coil, Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJNT. Eukaryota.
ENOG410Y4AG. LUCA.
GeneTreeiENSGT00390000006166.
HOGENOMiHOG000115581.
HOVERGENiHBG082152.
InParanoidiQ9BX97.
KOiK17309.
OMAiRNLWRDS.
OrthoDBiEOG091G0BG5.
PhylomeDBiQ9BX97.
TreeFamiTF337332.

Family and domain databases

InterProiView protein in InterPro
IPR009538. PV-1.
PfamiView protein in Pfam
PF06637. PV-1. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9BX97-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGLAMEHGGS YARAGGSSRG CWYYLRYFFL FVSLIQFLII LGLVLFMVYG
60 70 80 90 100
NVHVSTESNL QATERRAEGL YSQLLGLTAS QSNLTKELNF TTRAKDAIMQ
110 120 130 140 150
MWLNARRDLD RINASFRQCQ GDRVIYTNNQ RYMAAIILSE KQCRDQFKDM
160 170 180 190 200
NKSCDALLFM LNQKVKTLEV EIAKEKTICT KDKESVLLNK RVAEEQLVEC
210 220 230 240 250
VKTRELQHQE RQLAKEQLQK VQALCLPLDK DKFEMDLRNL WRDSIIPRSL
260 270 280 290 300
DNLGYNLYHP LGSELASIRR ACDHMPSLMS SKVEELARSL RADIERVARE
310 320 330 340 350
NSDLQRQKLE AQQGLRASQE AKQKVEKEAQ AREAKLQAEC SRQTQLALEE
360 370 380 390 400
KAVLRKERDN LAKELEEKKR EAEQLRMELA IRNSALDTCI KTKSQPMMPV
410 420 430 440
SRPMGPVPNP QPIDPASLEE FKRKILESQR PPAGIPVAPS SG
Length:442
Mass (Da):50,594
Last modified:June 1, 2001 - v1
Checksum:iD89ADBC9309A46FA
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti130Q → H in AAK11226 (Ref. 2) Curated1
Sequence conflicti328 – 332Missing in BAC04681 (PubMed:14702039).Curated5
Sequence conflicti439P → L in BAC04681 (PubMed:14702039).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF348827 mRNA. Translation: AAK20040.1.
AF326591 mRNA. Translation: AAK11226.1.
AK074054 mRNA. Translation: BAB84880.1.
AK096030 mRNA. Translation: BAC04681.1.
AL834363 mRNA. Translation: CAD39027.2.
BC050365 mRNA. Translation: AAH50365.2.
BC056414 mRNA. Translation: AAH56414.1.
CCDSiCCDS32952.1.
RefSeqiNP_112600.1. NM_031310.2.
UniGeneiHs.107125.

Genome annotation databases

EnsembliENST00000252590; ENSP00000252590; ENSG00000130300.
GeneIDi83483.
KEGGihsa:83483.
UCSCiuc002ngk.2. human.

Similar proteinsi

Entry informationi

Entry nameiPLVAP_HUMAN
AccessioniPrimary (citable) accession number: Q9BX97
Secondary accession number(s): Q86VP0
, Q8N8Y0, Q8ND68, Q8TER8, Q9BZD5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: June 1, 2001
Last modified: September 27, 2017
This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot