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Protein

Group XIIB secretory phospholipase A2-like protein

Gene

PLA2G12B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Not known; does not seem to have catalytic activity.

Cofactori

Ca2+By similarityNote: Binds 1 Ca2+ ion per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi89 – 891Calcium; via carbonyl oxygenBy similarity
Metal bindingi91 – 911Calcium; via carbonyl oxygenBy similarity
Metal bindingi93 – 931Calcium; via carbonyl oxygenBy similarity
Metal bindingi116 – 1161CalciumBy similarity

GO - Molecular functioni

  1. calcium ion binding Source: InterPro
  2. phospholipase A2 activity Source: InterPro

GO - Biological processi

  1. cholesterol homeostasis Source: Ensembl
  2. lipid catabolic process Source: InterPro
  3. triglyceride homeostasis Source: Ensembl
Complete GO annotation...

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Group XIIB secretory phospholipase A2-like protein
Alternative name(s):
Group XIII secretory phospholipase A2-like protein
Short name:
GXIII sPLA2-like
sPLA2-GXIIB
Short name:
GXIIB
Gene namesi
Name:PLA2G12B
Synonyms:PLA2G13
ORF Names:FKSG71
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:18555. PLA2G12B.

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38573.

Polymorphism and mutation databases

BioMutaiPLA2G12B.
DMDMi20178010.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 19191 PublicationAdd
BLAST
Chaini20 – 195176Group XIIB secretory phospholipase A2-like proteinPRO_0000022772Add
BLAST

Proteomic databases

MaxQBiQ9BX93.
PaxDbiQ9BX93.
PRIDEiQ9BX93.

PTM databases

PhosphoSiteiQ9BX93.

Expressioni

Tissue specificityi

Strong expression in liver, small intestine and kidney.1 Publication

Gene expression databases

BgeeiQ9BX93.
CleanExiHS_PLA2G12B.
GenevestigatoriQ9BX93.

Organism-specific databases

HPAiHPA057745.
HPA059562.

Interactioni

Protein-protein interaction databases

BioGridi124170. 3 interactions.
STRINGi9606.ENSP00000362123.

Structurei

3D structure databases

ProteinModelPortaliQ9BX93.
SMRiQ9BX93. Positions 82-174.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the phospholipase A2 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG85984.
GeneTreeiENSGT00390000008798.
HOGENOMiHOG000247019.
HOVERGENiHBG053577.
InParanoidiQ9BX93.
KOiK01047.
OMAiWGLRHIR.
OrthoDBiEOG7J1818.
PhylomeDBiQ9BX93.
TreeFamiTF323302.

Family and domain databases

InterProiIPR016090. PLipase_A2_dom.
IPR010711. PLipase_A2_secretory_G12.
[Graphical view]
PANTHERiPTHR12824. PTHR12824. 1 hit.
PfamiPF06951. PLA2G12. 1 hit.
[Graphical view]
SUPFAMiSSF48619. SSF48619. 1 hit.
PROSITEiPS00014. ER_TARGET. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9BX93-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKLASGFLVL WLSLGGGLAQ SDTSPDTEES YSDWGLRHLR GSFESVNSYF
60 70 80 90 100
DSFLELLGGK NGVCQYRCRY GKAPMPRPGY KPQEPNGCGS YFLGLKVPES
110 120 130 140 150
MDLGIPAMTK CCNQLDVCYD TCGANKYRCD AKFRWCLHSI CSDLKRSLGF
160 170 180 190
VSKVEAACDS LVDTVFNTVW TLGCRPFMNS QRAACICAEE EKEEL
Length:195
Mass (Da):21,659
Last modified:April 16, 2002 - v2
Checksum:iC00C817F81D68A70
GO
Isoform 2 (identifier: Q9BX93-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     157-157: Missing.

Show »
Length:194
Mass (Da):21,588
Checksum:i34DBFBFBDF9A22EC
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei157 – 1571Missing in isoform 2. 2 PublicationsVSP_054398

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF349540 mRNA. Translation: AAK30168.1.
AF339053 mRNA. Translation: AAL09472.1.
AY358032 mRNA. Translation: AAQ92918.1.
CH471083 Genomic DNA. Translation: EAW54466.1.
BC093996 mRNA. Translation: AAH93996.1.
BC111946 mRNA. Translation: AAI11947.1.
BC143532 mRNA. Translation: AAI43533.1.
CCDSiCCDS7319.1. [Q9BX93-1]
RefSeqiNP_115951.2. NM_032562.3. [Q9BX93-1]
XP_005270300.1. XM_005270243.3. [Q9BX93-2]
UniGeneiHs.333175.

Genome annotation databases

EnsembliENST00000373032; ENSP00000362123; ENSG00000138308. [Q9BX93-1]
GeneIDi84647.
KEGGihsa:84647.
UCSCiuc001jtf.1. human. [Q9BX93-1]
uc010qjz.1. human.

Polymorphism and mutation databases

BioMutaiPLA2G12B.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF349540 mRNA. Translation: AAK30168.1.
AF339053 mRNA. Translation: AAL09472.1.
AY358032 mRNA. Translation: AAQ92918.1.
CH471083 Genomic DNA. Translation: EAW54466.1.
BC093996 mRNA. Translation: AAH93996.1.
BC111946 mRNA. Translation: AAI11947.1.
BC143532 mRNA. Translation: AAI43533.1.
CCDSiCCDS7319.1. [Q9BX93-1]
RefSeqiNP_115951.2. NM_032562.3. [Q9BX93-1]
XP_005270300.1. XM_005270243.3. [Q9BX93-2]
UniGeneiHs.333175.

3D structure databases

ProteinModelPortaliQ9BX93.
SMRiQ9BX93. Positions 82-174.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124170. 3 interactions.
STRINGi9606.ENSP00000362123.

PTM databases

PhosphoSiteiQ9BX93.

Polymorphism and mutation databases

BioMutaiPLA2G12B.
DMDMi20178010.

Proteomic databases

MaxQBiQ9BX93.
PaxDbiQ9BX93.
PRIDEiQ9BX93.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000373032; ENSP00000362123; ENSG00000138308. [Q9BX93-1]
GeneIDi84647.
KEGGihsa:84647.
UCSCiuc001jtf.1. human. [Q9BX93-1]
uc010qjz.1. human.

Organism-specific databases

CTDi84647.
GeneCardsiGC10M074694.
HGNCiHGNC:18555. PLA2G12B.
HPAiHPA057745.
HPA059562.
MIMi611653. gene.
neXtProtiNX_Q9BX93.
PharmGKBiPA38573.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG85984.
GeneTreeiENSGT00390000008798.
HOGENOMiHOG000247019.
HOVERGENiHBG053577.
InParanoidiQ9BX93.
KOiK01047.
OMAiWGLRHIR.
OrthoDBiEOG7J1818.
PhylomeDBiQ9BX93.
TreeFamiTF323302.

Miscellaneous databases

GenomeRNAii84647.
NextBioi35481226.
PROiQ9BX93.
SOURCEiSearch...

Gene expression databases

BgeeiQ9BX93.
CleanExiHS_PLA2G12B.
GenevestigatoriQ9BX93.

Family and domain databases

InterProiIPR016090. PLipase_A2_dom.
IPR010711. PLipase_A2_secretory_G12.
[Graphical view]
PANTHERiPTHR12824. PTHR12824. 1 hit.
PfamiPF06951. PLA2G12. 1 hit.
[Graphical view]
SUPFAMiSSF48619. SSF48619. 1 hit.
PROSITEiPS00014. ER_TARGET. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of human group XIII secreted phospholipase A2."
    Takahashi K.
    Submitted (FEB-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
  2. "Cloning and characterization of FKSG71, a novel gene encoding group XIII secreted phospholipase A2."
    Wang Y.-G., Gong L.
    Submitted (JAN-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  3. "Novel mammalian group XII secreted phospholipase A2 lacking enzymatic activity."
    Rouault M., Bollinger J.G., Lazdunski M., Gelb M.H., Lambeau G.
    Biochemistry 42:11494-11503(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), LACK OF ENZYME ACTIVITY, TISSUE SPECIFICITY.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
  6. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."
    Zhang Z., Henzel W.J.
    Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 20-34.

Entry informationi

Entry nameiPG12B_HUMAN
AccessioniPrimary (citable) accession number: Q9BX93
Secondary accession number(s): B7ZL23, Q52LB2, Q96Q99
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 16, 2002
Last sequence update: April 16, 2002
Last modified: April 29, 2015
This is version 118 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.