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Q9BX93 (PG12B_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 112. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Group XIIB secretory phospholipase A2-like protein
Alternative name(s):
Group XIII secretory phospholipase A2-like protein
Short name=GXIII sPLA2-like
sPLA2-GXIIB
Short name=GXIIB
Gene names
Name:PLA2G12B
Synonyms:PLA2G13
ORF Names:FKSG71
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length195 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Not known; does not seem to have catalytic activity.

Cofactor

Binds 1 calcium ion per subunit By similarity.

Subcellular location

Secreted.

Tissue specificity

Strong expression in liver, small intestine and kidney. Ref.3

Sequence similarities

Belongs to the phospholipase A2 family.

Ontologies

Keywords
   Cellular componentSecreted
   Coding sequence diversityAlternative splicing
   DomainSignal
   LigandCalcium
Metal-binding
   Technical termComplete proteome
Direct protein sequencing
Reference proteome
Gene Ontology (GO)
   Biological_processlipid catabolic process

Inferred from electronic annotation. Source: InterPro

   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functioncalcium ion binding

Inferred from electronic annotation. Source: InterPro

phospholipase A2 activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9BX93-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9BX93-2)

The sequence of this isoform differs from the canonical sequence as follows:
     157-157: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1919 Ref.6
Chain20 – 195176Group XIIB secretory phospholipase A2-like protein
PRO_0000022772

Sites

Metal binding891Calcium; via carbonyl oxygen By similarity
Metal binding911Calcium; via carbonyl oxygen By similarity
Metal binding931Calcium; via carbonyl oxygen By similarity
Metal binding1161Calcium By similarity

Natural variations

Alternative sequence1571Missing in isoform 2.
VSP_054398

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified April 16, 2002. Version 2.
Checksum: C00C817F81D68A70

FASTA19521,659
        10         20         30         40         50         60 
MKLASGFLVL WLSLGGGLAQ SDTSPDTEES YSDWGLRHLR GSFESVNSYF DSFLELLGGK 

        70         80         90        100        110        120 
NGVCQYRCRY GKAPMPRPGY KPQEPNGCGS YFLGLKVPES MDLGIPAMTK CCNQLDVCYD 

       130        140        150        160        170        180 
TCGANKYRCD AKFRWCLHSI CSDLKRSLGF VSKVEAACDS LVDTVFNTVW TLGCRPFMNS 

       190 
QRAACICAEE EKEEL 

« Hide

Isoform 2 [UniParc].

Checksum: 34DBFBFBDF9A22EC
Show »

FASTA19421,588

References

« Hide 'large scale' references
[1]"Cloning of human group XIII secreted phospholipase A2."
Takahashi K.
Submitted (FEB-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
[2]"Cloning and characterization of FKSG71, a novel gene encoding group XIII secreted phospholipase A2."
Wang Y.-G., Gong L.
Submitted (JAN-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[3]"Novel mammalian group XII secreted phospholipase A2 lacking enzymatic activity."
Rouault M., Bollinger J.G., Lazdunski M., Gelb M.H., Lambeau G.
Biochemistry 42:11494-11503(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), LACK OF ENZYME ACTIVITY, TISSUE SPECIFICITY.
[4]Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
[6]"Signal peptide prediction based on analysis of experimentally verified cleavage sites."
Zhang Z., Henzel W.J.
Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 20-34.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF349540 mRNA. Translation: AAK30168.1.
AF339053 mRNA. Translation: AAL09472.1.
AY358032 mRNA. Translation: AAQ92918.1.
CH471083 Genomic DNA. Translation: EAW54466.1.
BC093996 mRNA. Translation: AAH93996.1.
BC111946 mRNA. Translation: AAI11947.1.
BC143532 mRNA. Translation: AAI43533.1.
CCDSCCDS7319.1.
RefSeqNP_115951.2. NM_032562.3. [Q9BX93-1]
XP_005270300.1. XM_005270243.2. [Q9BX93-2]
UniGeneHs.333175.

3D structure databases

ProteinModelPortalQ9BX93.
SMRQ9BX93. Positions 82-174.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000362123.

PTM databases

PhosphoSiteQ9BX93.

Polymorphism databases

DMDM20178010.

Proteomic databases

MaxQBQ9BX93.
PaxDbQ9BX93.
PRIDEQ9BX93.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000373032; ENSP00000362123; ENSG00000138308.
GeneID84647.
KEGGhsa:84647.
UCSCuc001jtf.1. human. [Q9BX93-1]

Organism-specific databases

CTD84647.
GeneCardsGC10M074694.
HGNCHGNC:18555. PLA2G12B.
HPAHPA057745.
HPA059562.
MIM611653. gene.
neXtProtNX_Q9BX93.
PharmGKBPA38573.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG85984.
HOGENOMHOG000247019.
HOVERGENHBG053577.
InParanoidQ9BX93.
KOK01047.
OMAWGLRHIR.
OrthoDBEOG7J1818.
PhylomeDBQ9BX93.
TreeFamTF323302.

Gene expression databases

ArrayExpressQ9BX93.
BgeeQ9BX93.
CleanExHS_PLA2G12B.
GenevestigatorQ9BX93.

Family and domain databases

InterProIPR016090. PLipase_A2_dom.
IPR010711. PLipase_A2_secretory_G12.
[Graphical view]
PANTHERPTHR12824. PTHR12824. 1 hit.
PfamPF06951. PLA2G12. 1 hit.
[Graphical view]
SUPFAMSSF48619. SSF48619. 1 hit.
PROSITEPS00014. ER_TARGET. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi84647.
NextBio35481226.
PROQ9BX93.
SOURCESearch...

Entry information

Entry namePG12B_HUMAN
AccessionPrimary (citable) accession number: Q9BX93
Secondary accession number(s): B7ZL23, Q52LB2, Q96Q99
Entry history
Integrated into UniProtKB/Swiss-Prot: April 16, 2002
Last sequence update: April 16, 2002
Last modified: July 9, 2014
This is version 112 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 10

Human chromosome 10: entries, gene names and cross-references to MIM