Q9BX93 (PG12B_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Group XIIB secretory phospholipase A2-like protein

Alternative name(s):
Group XIII secretory phospholipase A2-like protein
Short name=GXIII sPLA2-like
sPLA2-GXIIB
Short name=GXIIB

Gene names

Name:	PLA2G12B
Synonyms:	PLA2G13
ORF Names:	FKSG71

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	195 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Not known; does not seem to have catalytic activity.
Cofactor	Binds 1 calcium ion per subunit By similarity.
Subcellular location	Secreted.
Tissue specificity	Strong expression in liver, small intestine and kidney. Ref.3
Sequence similarities	Belongs to the phospholipase A2 family.

Ontologies

Keywords
Cellular component	Secreted
Domain	Signal
Ligand	Calcium Metal-binding
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological process	lipid catabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	calcium ion binding Inferred from electronic annotation. Source: InterPro phospholipase A2 activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 19	19	Ref.5
	Chain	20 – 195	176	Group XIIB secretory phospholipase A2-like protein		PRO_0000022772
Sites
	Metal binding	89	1	Calcium; via carbonyl oxygen By similarity
	Metal binding	91	1	Calcium; via carbonyl oxygen By similarity
	Metal binding	93	1	Calcium; via carbonyl oxygen By similarity
	Metal binding	116	1	Calcium By similarity
Experimental info
	Sequence conflict	157	1	Missing in AAK30168. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q9BX93 [UniParc]. Last modified April 16, 2002. Version 2. Checksum: C00C817F81D68A70	FASTA	195	21,659
	10 20 30 40 50 60 MKLASGFLVL WLSLGGGLAQ SDTSPDTEES YSDWGLRHLR GSFESVNSYF DSFLELLGGK 70 80 90 100 110 120 NGVCQYRCRY GKAPMPRPGY KPQEPNGCGS YFLGLKVPES MDLGIPAMTK CCNQLDVCYD 130 140 150 160 170 180 TCGANKYRCD AKFRWCLHSI CSDLKRSLGF VSKVEAACDS LVDTVFNTVW TLGCRPFMNS 190 QRAACICAEE EKEEL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning of human group XIII secreted phospholipase A2." Takahashi K. Submitted (FEB-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Cloning and characterization of FKSG71, a novel gene encoding group XIII secreted phospholipase A2." Wang Y.-G., Gong L. Submitted (JAN-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]	"Novel mammalian group XII secreted phospholipase A2 lacking enzymatic activity." Rouault M., Bollinger J.G., Lazdunski M., Gelb M.H., Lambeau G. Biochemistry 42:11494-11503(2003) [PubMed: 14516201] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], LACK OF ENZYME ACTIVITY, TISSUE SPECIFICITY.
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[5]	"Signal peptide prediction based on analysis of experimentally verified cleavage sites." Zhang Z., Henzel W.J. Protein Sci. 13:2819-2824(2004) [PubMed: 15340161] [Abstract] Cited for: PROTEIN SEQUENCE OF 20-34.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF349540 mRNA. Translation: AAK30168.1. AF339053 mRNA. Translation: AAL09472.1. AY358032 mRNA. Translation: AAQ92918.1. BC093996 mRNA. Translation: AAH93996.1. BC111946 mRNA. Translation: AAI11947.1.
IPI	IPI00000240.
RefSeq	NP_115951.2. NM_032562.2.
UniGene	Hs.333175.
3D structure databases
ProteinModelPortal	Q9BX93.
ModBase	Search...
Protein-protein interaction databases
STRING	Q9BX93.
Polymorphism databases
DMDM	20178010.
Proteomic databases
PRIDE	Q9BX93.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000373032; ENSP00000362123; ENSG00000138308.
GeneID	84647.
KEGG	hsa:84647.
UCSC	uc001jtf.1. human.
Organism-specific databases
CTD	84647.
GeneCards	GC10M074694.
H-InvDB	HIX0035338.
HGNC	HGNC:18555. PLA2G12B.
MIM	611653. gene.
neXtProt	NX_Q9BX93.
PharmGKB	PA38573.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG13747.
GeneTree	ENSGT00390000008798.
HOGENOM	HBG714426.
HOVERGEN	HBG053577.
InParanoid	Q9BX93.
OMA	VACDSLV.
OrthoDB	EOG40K80X.
PhylomeDB	Q9BX93.
Gene expression databases
ArrayExpress	Q9BX93.
Bgee	Q9BX93.
CleanEx	HS_PLA2G12B.
Genevestigator	Q9BX93.
GermOnline	ENSG00000138308. Homo sapiens.
Family and domain databases
InterPro	IPR016090. PLipase_A2. IPR010711. PLipase_A2_secretory_G12. [Graphical view]
Gene3D	G3DSA:1.20.90.10. Phospholipase_A2. 1 hit.
KO	K01047.
PANTHER	PTHR12824. PLA2G12. 1 hit.
Pfam	PF06951. PLA2G12. 1 hit. [Graphical view]
SUPFAM	SSF48619. PhospholipaseA2. 1 hit.
PROSITE	PS00014. ER_TARGET. 1 hit. Uncertain. PS00119. PA2_ASP. False negative. PS00118. PA2_HIS. False negative. [Graphical view]
ProtoNet	Search...
Other
NextBio	74594.
SOURCE	Search...

Entry information

Entry name

PG12B_HUMAN

Accession

Primary (citable) accession number: Q9BX93
Secondary accession number(s): Q52LB2, Q96Q99

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 16, 2002
Last sequence update:	April 16, 2002
Last modified:	January 25, 2012
This is version 91 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.