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Q9BX93

- PG12B_HUMAN

UniProt

Q9BX93 - PG12B_HUMAN

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Protein

Group XIIB secretory phospholipase A2-like protein

Gene

PLA2G12B

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Not known; does not seem to have catalytic activity.

Cofactori

Binds 1 calcium ion per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi89 – 891Calcium; via carbonyl oxygenBy similarity
Metal bindingi91 – 911Calcium; via carbonyl oxygenBy similarity
Metal bindingi93 – 931Calcium; via carbonyl oxygenBy similarity
Metal bindingi116 – 1161CalciumBy similarity

GO - Molecular functioni

  1. calcium ion binding Source: InterPro
  2. phospholipase A2 activity Source: InterPro

GO - Biological processi

  1. cholesterol homeostasis Source: Ensembl
  2. lipid catabolic process Source: InterPro
  3. triglyceride homeostasis Source: Ensembl
Complete GO annotation...

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Group XIIB secretory phospholipase A2-like protein
Alternative name(s):
Group XIII secretory phospholipase A2-like protein
Short name:
GXIII sPLA2-like
sPLA2-GXIIB
Short name:
GXIIB
Gene namesi
Name:PLA2G12B
Synonyms:PLA2G13
ORF Names:FKSG71
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 10

Organism-specific databases

HGNCiHGNC:18555. PLA2G12B.

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38573.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 19191 PublicationAdd
BLAST
Chaini20 – 195176Group XIIB secretory phospholipase A2-like proteinPRO_0000022772Add
BLAST

Proteomic databases

MaxQBiQ9BX93.
PaxDbiQ9BX93.
PRIDEiQ9BX93.

PTM databases

PhosphoSiteiQ9BX93.

Expressioni

Tissue specificityi

Strong expression in liver, small intestine and kidney.1 Publication

Gene expression databases

BgeeiQ9BX93.
CleanExiHS_PLA2G12B.
GenevestigatoriQ9BX93.

Organism-specific databases

HPAiHPA057745.
HPA059562.

Interactioni

Protein-protein interaction databases

BioGridi124170. 3 interactions.
STRINGi9606.ENSP00000362123.

Structurei

3D structure databases

ProteinModelPortaliQ9BX93.
SMRiQ9BX93. Positions 82-174.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the phospholipase A2 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG85984.
GeneTreeiENSGT00390000008798.
HOGENOMiHOG000247019.
HOVERGENiHBG053577.
InParanoidiQ9BX93.
KOiK01047.
OMAiWGLRHIR.
OrthoDBiEOG7J1818.
PhylomeDBiQ9BX93.
TreeFamiTF323302.

Family and domain databases

InterProiIPR016090. PLipase_A2_dom.
IPR010711. PLipase_A2_secretory_G12.
[Graphical view]
PANTHERiPTHR12824. PTHR12824. 1 hit.
PfamiPF06951. PLA2G12. 1 hit.
[Graphical view]
SUPFAMiSSF48619. SSF48619. 1 hit.
PROSITEiPS00014. ER_TARGET. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9BX93-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKLASGFLVL WLSLGGGLAQ SDTSPDTEES YSDWGLRHLR GSFESVNSYF
60 70 80 90 100
DSFLELLGGK NGVCQYRCRY GKAPMPRPGY KPQEPNGCGS YFLGLKVPES
110 120 130 140 150
MDLGIPAMTK CCNQLDVCYD TCGANKYRCD AKFRWCLHSI CSDLKRSLGF
160 170 180 190
VSKVEAACDS LVDTVFNTVW TLGCRPFMNS QRAACICAEE EKEEL
Length:195
Mass (Da):21,659
Last modified:April 16, 2002 - v2
Checksum:iC00C817F81D68A70
GO
Isoform 2 (identifier: Q9BX93-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     157-157: Missing.

Show »
Length:194
Mass (Da):21,588
Checksum:i34DBFBFBDF9A22EC
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei157 – 1571Missing in isoform 2. 2 PublicationsVSP_054398

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF349540 mRNA. Translation: AAK30168.1.
AF339053 mRNA. Translation: AAL09472.1.
AY358032 mRNA. Translation: AAQ92918.1.
CH471083 Genomic DNA. Translation: EAW54466.1.
BC093996 mRNA. Translation: AAH93996.1.
BC111946 mRNA. Translation: AAI11947.1.
BC143532 mRNA. Translation: AAI43533.1.
CCDSiCCDS7319.1. [Q9BX93-1]
RefSeqiNP_115951.2. NM_032562.3. [Q9BX93-1]
XP_005270300.1. XM_005270243.2. [Q9BX93-2]
UniGeneiHs.333175.

Genome annotation databases

EnsembliENST00000373032; ENSP00000362123; ENSG00000138308. [Q9BX93-1]
GeneIDi84647.
KEGGihsa:84647.
UCSCiuc001jtf.1. human. [Q9BX93-1]
uc010qjz.1. human.

Polymorphism databases

DMDMi20178010.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF349540 mRNA. Translation: AAK30168.1 .
AF339053 mRNA. Translation: AAL09472.1 .
AY358032 mRNA. Translation: AAQ92918.1 .
CH471083 Genomic DNA. Translation: EAW54466.1 .
BC093996 mRNA. Translation: AAH93996.1 .
BC111946 mRNA. Translation: AAI11947.1 .
BC143532 mRNA. Translation: AAI43533.1 .
CCDSi CCDS7319.1. [Q9BX93-1 ]
RefSeqi NP_115951.2. NM_032562.3. [Q9BX93-1 ]
XP_005270300.1. XM_005270243.2. [Q9BX93-2 ]
UniGenei Hs.333175.

3D structure databases

ProteinModelPortali Q9BX93.
SMRi Q9BX93. Positions 82-174.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 124170. 3 interactions.
STRINGi 9606.ENSP00000362123.

PTM databases

PhosphoSitei Q9BX93.

Polymorphism databases

DMDMi 20178010.

Proteomic databases

MaxQBi Q9BX93.
PaxDbi Q9BX93.
PRIDEi Q9BX93.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000373032 ; ENSP00000362123 ; ENSG00000138308 . [Q9BX93-1 ]
GeneIDi 84647.
KEGGi hsa:84647.
UCSCi uc001jtf.1. human. [Q9BX93-1 ]
uc010qjz.1. human.

Organism-specific databases

CTDi 84647.
GeneCardsi GC10M074694.
HGNCi HGNC:18555. PLA2G12B.
HPAi HPA057745.
HPA059562.
MIMi 611653. gene.
neXtProti NX_Q9BX93.
PharmGKBi PA38573.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG85984.
GeneTreei ENSGT00390000008798.
HOGENOMi HOG000247019.
HOVERGENi HBG053577.
InParanoidi Q9BX93.
KOi K01047.
OMAi WGLRHIR.
OrthoDBi EOG7J1818.
PhylomeDBi Q9BX93.
TreeFami TF323302.

Miscellaneous databases

GenomeRNAii 84647.
NextBioi 35481226.
PROi Q9BX93.
SOURCEi Search...

Gene expression databases

Bgeei Q9BX93.
CleanExi HS_PLA2G12B.
Genevestigatori Q9BX93.

Family and domain databases

InterProi IPR016090. PLipase_A2_dom.
IPR010711. PLipase_A2_secretory_G12.
[Graphical view ]
PANTHERi PTHR12824. PTHR12824. 1 hit.
Pfami PF06951. PLA2G12. 1 hit.
[Graphical view ]
SUPFAMi SSF48619. SSF48619. 1 hit.
PROSITEi PS00014. ER_TARGET. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of human group XIII secreted phospholipase A2."
    Takahashi K.
    Submitted (FEB-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
  2. "Cloning and characterization of FKSG71, a novel gene encoding group XIII secreted phospholipase A2."
    Wang Y.-G., Gong L.
    Submitted (JAN-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  3. "Novel mammalian group XII secreted phospholipase A2 lacking enzymatic activity."
    Rouault M., Bollinger J.G., Lazdunski M., Gelb M.H., Lambeau G.
    Biochemistry 42:11494-11503(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), LACK OF ENZYME ACTIVITY, TISSUE SPECIFICITY.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
  6. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."
    Zhang Z., Henzel W.J.
    Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 20-34.

Entry informationi

Entry nameiPG12B_HUMAN
AccessioniPrimary (citable) accession number: Q9BX93
Secondary accession number(s): B7ZL23, Q52LB2, Q96Q99
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 16, 2002
Last sequence update: April 16, 2002
Last modified: October 29, 2014
This is version 115 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3