Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Transient receptor potential cation channel subfamily M member 6

Gene

TRPM6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Essential ion channel and serine/threonine-protein kinase. Crucial for magnesium homeostasis. Has an important role in epithelial magnesium transport and in the active magnesium absorption in the gut and kidney. Isoforms of the type M6-kinase lack the ion channel region.

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei1780ATPBy similarity1
Binding sitei1804ATPBy similarity1
Binding sitei1876ATPBy similarity1
Metal bindingi1909ZincBy similarity1
Active sitei1923Proton acceptorBy similarity1
Binding sitei1925ATPBy similarity1
Binding sitei1933ATPBy similarity1
Metal bindingi1966ZincBy similarity1
Metal bindingi1968ZincBy similarity1
Metal bindingi1972ZincBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi1950 – 1956ATPBy similarity7

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Calcium channel, Ion channel, Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Biological processi

Calcium transport, Ion transport, Transport

Keywords - Ligandi

ATP-binding, Calcium, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:HS04275-MONOMER.
ReactomeiR-HSA-3295583. TRP channels.

Protein family/group databases

TCDBi1.A.4.5.8. the transient receptor potential ca(2+) channel (trp-cc) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Transient receptor potential cation channel subfamily M member 6 (EC:2.7.11.1)
Alternative name(s):
Channel kinase 2
Melastatin-related TRP cation channel 6
Gene namesi
Name:TRPM6
Synonyms:CHAK2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:17995. TRPM6.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 741CytoplasmicSequence analysisAdd BLAST741
Transmembranei742 – 762HelicalSequence analysisAdd BLAST21
Topological domaini763 – 841ExtracellularSequence analysisAdd BLAST79
Transmembranei842 – 862HelicalSequence analysisAdd BLAST21
Topological domaini863 – 905CytoplasmicSequence analysisAdd BLAST43
Transmembranei906 – 926HelicalSequence analysisAdd BLAST21
Topological domaini927 – 939ExtracellularSequence analysisAdd BLAST13
Transmembranei940 – 960HelicalSequence analysisAdd BLAST21
Topological domaini961 – 972CytoplasmicSequence analysisAdd BLAST12
Transmembranei973 – 993HelicalSequence analysisAdd BLAST21
Topological domaini994 – 1012ExtracellularSequence analysisAdd BLAST19
Intramembranei1013 – 1033Pore-formingSequence analysisAdd BLAST21
Topological domaini1034 – 1047ExtracellularSequence analysisAdd BLAST14
Transmembranei1048 – 1068HelicalSequence analysisAdd BLAST21
Topological domaini1069 – 2022CytoplasmicSequence analysisAdd BLAST954

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Involvement in diseasei

Hypomagnesemia 1 (HOMG1)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disorder due to a primary defect in intestinal magnesium absorption. It is characterized by low levels of serum magnesium alongside with a normal renal magnesium secretion, secondary hypocalcemia and calcinocis. Affected individuals show neurologic symptoms of hypomagnesemic hypocalcemia, including seizures and muscle spasms, during infancy. Hypocalcemia is secondary to parathyroid failure resulting from magnesium deficiency. Untreated, the disorder may be fatal or may result in neurological damage.
See also OMIM:602014
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_019963141S → L in HOMG1; impairs heterodimer formation resulting in intracellular retention. 2 PublicationsCorresponds to variant rs121912625dbSNPEnsembl.1
Natural variantiVAR_071480708L → P in HOMG1; loss of function; no effect on cell membrane localization. 1 Publication1
Natural variantiVAR_071481872E → G in HOMG1; loss of function; no effect on cell membrane localization. 1 Publication1
Natural variantiVAR_0714821053Y → C in HOMG1; loss of function; no effect on cell membrane localization. 1 Publication1
Natural variantiVAR_0714831143L → P in HOMG1; loss of function; no effect on cell membrane localization. 1 Publication1
Natural variantiVAR_0714841754S → N in HOMG1; loss of function; no effect on cell membrane localization. 1 Publication1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi1804K → R: Abolishes kinase activity but does not affect expression levels or binding to RACK1. 1 Publication1
Mutagenesisi1851T → A: Significantly decreases autophosphorylation. Does not alter binding to RACK1 but prevents inhibition by RACK1. 1 Publication1
Mutagenesisi1851T → D: Significantly decreases autophosphorylation. Does not alter binding to RACK1 or inhibition by RACK1. 1 Publication1

Keywords - Diseasei

Disease mutation, Primary hypomagnesemia

Organism-specific databases

DisGeNETi140803.
MalaCardsiTRPM6.
MIMi602014. phenotype.
OpenTargetsiENSG00000119121.
Orphaneti30924. Primary hypomagnesemia with secondary hypocalcemia.
PharmGKBiPA38479.

Chemistry databases

ChEMBLiCHEMBL1628470.
GuidetoPHARMACOLOGYi498.

Polymorphism and mutation databases

BioMutaiTRPM6.
DMDMi56404951.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002153291 – 2022Transient receptor potential cation channel subfamily M member 6Add BLAST2022

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1851Phosphothreonine; by autocatalysis1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9BX84.
PaxDbiQ9BX84.
PeptideAtlasiQ9BX84.
PRIDEiQ9BX84.

PTM databases

iPTMnetiQ9BX84.
PhosphoSitePlusiQ9BX84.

Expressioni

Tissue specificityi

Highly expressed in kidney and colon. Isoform TRPM6a and isoform TRPM6b, are coexpressed with TRPM7 in kidney, and testis, and are also found in several cell lines of lung origin. Isoform TRPM6c is detected only in testis and in NCI-H510A small cell lung carcinoma cells.

Gene expression databases

BgeeiENSG00000119121.
CleanExiHS_TRPM6.
ExpressionAtlasiQ9BX84. baseline and differential.
GenevisibleiQ9BX84. HS.

Organism-specific databases

HPAiHPA007037.

Interactioni

Subunit structurei

Forms heterodimers with TRPM7. TRPM6 requires the presence of TRPM7 to be targeted to the cell membrane (in HEK 293 cells). Interacts (via kinase domain) with RACK1.2 Publications

Protein-protein interaction databases

IntActiQ9BX84. 3 interactors.
MINTiMINT-6699468.
STRINGi9606.ENSP00000354006.

Chemistry databases

BindingDBiQ9BX84.

Structurei

3D structure databases

ProteinModelPortaliQ9BX84.
SMRiQ9BX84.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1750 – 1980Alpha-type protein kinasePROSITE-ProRule annotationAdd BLAST231

Sequence similaritiesi

In the C-terminal section; belongs to the protein kinase superfamily. Alpha-type protein kinase family. ALPK subfamily.Curated
Contains 1 alpha-type protein kinase domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410INBW. Eukaryota.
ENOG410ZSH9. LUCA.
GeneTreeiENSGT00760000119127.
HOGENOMiHOG000230920.
HOVERGENiHBG055663.
InParanoidiQ9BX84.
KOiK04981.
OMAiLMECMVH.
OrthoDBiEOG091G0DHL.
PhylomeDBiQ9BX84.
TreeFamiTF314204.

Family and domain databases

InterProiIPR005821. Ion_trans_dom.
IPR011009. Kinase-like_dom.
IPR004166. MHCK_EF2_kinase.
IPR029597. TRPM6.
IPR032415. TRPM_tetra.
[Graphical view]
PANTHERiPTHR13800:SF15. PTHR13800:SF15. 2 hits.
PfamiPF02816. Alpha_kinase. 1 hit.
PF00520. Ion_trans. 1 hit.
PF16519. TRPM_tetra. 1 hit.
[Graphical view]
SMARTiSM00811. Alpha_kinase. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS51158. ALPHA_KINASE. 1 hit.
[Graphical view]

Sequences (7)i

Sequence statusi: Complete.

This entry describes 7 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform TRPM6a (identifier: Q9BX84-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKEQPVLERL QSQKSWIKGV FDKRECSTII PSSKNPHRCT PVCQVCQNLI
60 70 80 90 100
RCYCGRLIGD HAGIDYSWTI SAAKGKESEQ WSVEKHTTKS PTDTFGTINF
110 120 130 140 150
QDGEHTHHAK YIRTSYDTKL DHLLHLMLKE WKMELPKLVI SVHGGIQNFT
160 170 180 190 200
MPSKFKEIFS QGLVKAAETT GAWIITEGIN TGVSKHVGDA LKSHSSHSLR
210 220 230 240 250
KIWTVGIPPW GVIENQRDLI GKDVVCLYQT LDNPLSKLTT LNSMHSHFIL
260 270 280 290 300
SDDGTVGKYG NEMKLRRNLE KYLSLQKIHC RSRQGVPVVG LVVEGGPNVI
310 320 330 340 350
LSVWETVKDK DPVVVCEGTG RAADLLAFTH KHLADEGMLR PQVKEEIICM
360 370 380 390 400
IQNTFNFSLK QSKHLFQILM ECMVHRDCIT IFDADSEEQQ DLDLAILTAL
410 420 430 440 450
LKGTNLSASE QLNLAMAWDR VDIAKKHILI YEQHWKPDAL EQAMSDALVM
460 470 480 490 500
DRVDFVKLLI EYGVNLHRFL TIPRLEELYN TKQGPTNTLL HHLVQDVKQH
510 520 530 540 550
TLLSGYRITL IDIGLVVEYL IGRAYRSNYT RKHFRALYNN LYRKYKHQRH
560 570 580 590 600
SSGNRNESAE STLHSQFIRT AQPYKFKEKS IVLHKSRKKS KEQNVSDDPE
610 620 630 640 650
STGFLYPYND LLVWAVLMKR QKMAMFFWQH GEEATVKAVI ACILYRAMAH
660 670 680 690 700
EAKESHMVDD ASEELKNYSK QFGQLALDLL EKAFKQNERM AMTLLTYELR
710 720 730 740 750
NWSNSTCLKL AVSGGLRPFV SHTCTQMLLT DMWMGRLKMR KNSWLKIIIS
760 770 780 790 800
IILPPTILTL EFKSKAEMSH VPQSQDFQFM WYYSDQNASS SKESASVKEY
810 820 830 840 850
DLERGHDEKL DENQHFGLES GHQHLPWTRK VYEFYSAPIV KFWFYTMAYL
860 870 880 890 900
AFLMLFTYTV LVEMQPQPSV QEWLVSIYIF TNAIEVVREI CISEPGKFTQ
910 920 930 940 950
KVKVWISEYW NLTETVAIGL FSAGFVLRWG DPPFHTAGRL IYCIDIIFWF
960 970 980 990 1000
SRLLDFFAVN QHAGPYVTMI AKMTANMFYI VIIMAIVLLS FGVARKAILS
1010 1020 1030 1040 1050
PKEPPSWSLA RDIVFEPYWM IYGEVYAGEI DVCSSQPSCP PGSFLTPFLQ
1060 1070 1080 1090 1100
AVYLFVQYII MVNLLIAFFN NVYLDMESIS NNLWKYNRYR YIMTYHEKPW
1110 1120 1130 1140 1150
LPPPLILLSH VGLLLRRLCC HRAPHDQEEG DVGLKLYLSK EDLKKLHDFE
1160 1170 1180 1190 1200
EQCVEKYFHE KMEDVNCSCE ERIRVTSERV TEMYFQLKEM NEKVSFIKDS
1210 1220 1230 1240 1250
LLSLDSQVGH LQDLSALTVD TLKVLSAVDT LQEDEALLAK RKHSTCKKLP
1260 1270 1280 1290 1300
HSWSNVICAE VLGSMEIAGE KKYQYYSMPS SLLRSLAGGR HPPRVQRGAL
1310 1320 1330 1340 1350
LEITNSKREA TNVRNDQERQ ETQSSIVVSG VSPNRQAHSK YGQFLLVPSN
1360 1370 1380 1390 1400
LKRVPFSAET VLPLSRPSVP DVLATEQDIQ TEVLVHLTGQ TPVVSDWASV
1410 1420 1430 1440 1450
DEPKEKHEPI AHLLDGQDKA EQVLPTLSCT PEPMTMSSPL SQAKIMQTGG
1460 1470 1480 1490 1500
GYVNWAFSEG DETGVFSIKK KWQTCLPSTC DSDSSRSEQH QKQAQDSSLS
1510 1520 1530 1540 1550
DNSTRSAQSS ECSEVGPWLQ PNTSFWINPL RRYRPFARSH SFRFHKEEKL
1560 1570 1580 1590 1600
MKICKIKNLS GSSEIGQGAW VKAKMLTKDR RLSKKKKNTQ GLQVPIITVN
1610 1620 1630 1640 1650
ACSQSDQLNP EPGENSISEE EYSKNWFTVS KFSHTGVEPY IHQKMKTKEI
1660 1670 1680 1690 1700
GQCAIQISDY LKQSQEDLSK NSLWNSRSTN LNRNSLLKSS IGVDKISASL
1710 1720 1730 1740 1750
KSPQEPHHHY SAIERNNLMR LSQTIPFTPV QLFAGEEITV YRLEESSPLN
1760 1770 1780 1790 1800
LDKSMSSWSQ RGRAAMIQVL SREEMDGGLR KAMRVVSTWS EDDILKPGQV
1810 1820 1830 1840 1850
FIVKSFLPEV VRTWHKIFQE STVLHLCLRE IQQQRAAQKL IYTFNQVKPQ
1860 1870 1880 1890 1900
TIPYTPRFLE VFLIYCHSAN QWLTIEKYMT GEFRKYNNNN GDEITPTNTL
1910 1920 1930 1940 1950
EELMLAFSHW TYEYTRGELL VLDLQGVGEN LTDPSVIKPE VKQSRGMVFG
1960 1970 1980 1990 2000
PANLGEDAIR NFIAKHHCNS CCRKLKLPDL KRNDYSPERI NSTFGLEIKI
2010 2020
ESAEEPPARE TGRNSPEDDM QL
Length:2,022
Mass (Da):231,708
Last modified:June 1, 2002 - v2
Checksum:i59346B3BE3300466
GO
Isoform TRPM6b (identifier: Q9BX84-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-11: MKEQPVLERLQ → MIILSK

Show »
Length:2,017
Mass (Da):231,041
Checksum:iC96D328F3E9B2A9E
GO
Isoform TRPM6c (identifier: Q9BX84-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-11: MKEQPVLERLQ → MTAPVT

Show »
Length:2,017
Mass (Da):230,956
Checksum:i7F49198CADF3F64D
GO
Isoform TRPM6t (identifier: Q9BX84-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1926-1943: GVGENLTDPSVIKPEVKQ → ALWFWDSMLKARLGGWRM
     1944-2022: Missing.

Show »
Length:1,943
Mass (Da):223,124
Checksum:i15F59730C0F345EC
GO
Isoform M6-kinase 1 (identifier: Q9BX84-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     547-1595: Missing.

Note: Lacks the ion channel region.
Show »
Length:973
Mass (Da):111,301
Checksum:i4B6503C01BF3F3B6
GO
Isoform M6-kinase 2 (identifier: Q9BX84-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     500-1666: Missing.

Note: Lacks the ion channel region.
Show »
Length:855
Mass (Da):97,520
Checksum:i924C00E589E6FED0
GO
Isoform M6-kinase 3 (identifier: Q9BX84-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     281-281: R → P
     282-1734: Missing.

Note: Lacks the ion channel region.
Show »
Length:569
Mass (Da):65,083
Checksum:i7BF7F1E5163459EF
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04238775G → V in a lung adenocarcinoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_019963141S → L in HOMG1; impairs heterodimer formation resulting in intracellular retention. 2 PublicationsCorresponds to variant rs121912625dbSNPEnsembl.1
Natural variantiVAR_042388338M → I.1 PublicationCorresponds to variant rs56155062dbSNPEnsembl.1
Natural variantiVAR_071480708L → P in HOMG1; loss of function; no effect on cell membrane localization. 1 Publication1
Natural variantiVAR_071481872E → G in HOMG1; loss of function; no effect on cell membrane localization. 1 Publication1
Natural variantiVAR_052380948F → L.Corresponds to variant rs13290391dbSNPEnsembl.1
Natural variantiVAR_0423891007W → C in a lung large cell carcinoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_0714821053Y → C in HOMG1; loss of function; no effect on cell membrane localization. 1 Publication1
Natural variantiVAR_0199641071N → D.Corresponds to variant rs2274922dbSNPEnsembl.1
Natural variantiVAR_0714831143L → P in HOMG1; loss of function; no effect on cell membrane localization. 1 Publication1
Natural variantiVAR_0423901243H → R.1 PublicationCorresponds to variant rs55694430dbSNPEnsembl.1
Natural variantiVAR_0423911274Q → R.1 PublicationCorresponds to variant rs34608911dbSNPEnsembl.1
Natural variantiVAR_0199651393V → I.1 PublicationCorresponds to variant rs3750425dbSNPEnsembl.1
Natural variantiVAR_0199661584K → E.1 PublicationCorresponds to variant rs2274924dbSNPEnsembl.1
Natural variantiVAR_0423921663Q → R No effect on function or cell membrane localization. 2 PublicationsCorresponds to variant rs55679040dbSNPEnsembl.1
Natural variantiVAR_0423931673L → S.1 PublicationCorresponds to variant rs56254742dbSNPEnsembl.1
Natural variantiVAR_0423941724T → I.1 PublicationCorresponds to variant rs56290308dbSNPEnsembl.1
Natural variantiVAR_0714841754S → N in HOMG1; loss of function; no effect on cell membrane localization. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0120691 – 11MKEQPVLERLQ → MIILSK in isoform TRPM6b. 1 PublicationAdd BLAST11
Alternative sequenceiVSP_0120701 – 11MKEQPVLERLQ → MTAPVT in isoform TRPM6c. 1 PublicationAdd BLAST11
Alternative sequenceiVSP_012071281R → P in isoform M6-kinase 3. 1 Publication1
Alternative sequenceiVSP_012072282 – 1734Missing in isoform M6-kinase 3. 1 PublicationAdd BLAST1453
Alternative sequenceiVSP_012073500 – 1666Missing in isoform M6-kinase 2. 1 PublicationAdd BLAST1167
Alternative sequenceiVSP_012074547 – 1595Missing in isoform M6-kinase 1. 1 PublicationAdd BLAST1049
Alternative sequenceiVSP_0120751926 – 1943GVGEN…PEVKQ → ALWFWDSMLKARLGGWRM in isoform TRPM6t. 1 PublicationAdd BLAST18
Alternative sequenceiVSP_0120761944 – 2022Missing in isoform TRPM6t. 1 PublicationAdd BLAST79

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF350881 mRNA. Translation: AAK31202.2.
AF448232 mRNA. Translation: AAM21562.1.
AY333282 mRNA. Translation: AAR03487.1.
AY333283 mRNA. Translation: AAR03488.1.
AY333284 mRNA. Translation: AAR03489.1.
AY333285 mRNA. Translation: AAR03490.1.
AY333286 mRNA. Translation: AAR03491.1.
AY333287 mRNA. Translation: AAR03492.1.
AY333288 mRNA. Translation: AAR03493.1.
AL354795 Genomic DNA. Translation: CAH70894.1.
CCDSiCCDS55318.1. [Q9BX84-3]
CCDS55319.1. [Q9BX84-2]
CCDS6647.1. [Q9BX84-1]
RefSeqiNP_001170781.1. NM_001177310.1. [Q9BX84-2]
NP_001170782.1. NM_001177311.1. [Q9BX84-3]
NP_060132.3. NM_017662.4. [Q9BX84-1]
UniGeneiHs.272225.

Genome annotation databases

EnsembliENST00000360774; ENSP00000354006; ENSG00000119121. [Q9BX84-1]
ENST00000361255; ENSP00000354962; ENSG00000119121. [Q9BX84-3]
ENST00000449912; ENSP00000396672; ENSG00000119121. [Q9BX84-2]
GeneIDi140803.
KEGGihsa:140803.
UCSCiuc004ajk.1. human. [Q9BX84-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF350881 mRNA. Translation: AAK31202.2.
AF448232 mRNA. Translation: AAM21562.1.
AY333282 mRNA. Translation: AAR03487.1.
AY333283 mRNA. Translation: AAR03488.1.
AY333284 mRNA. Translation: AAR03489.1.
AY333285 mRNA. Translation: AAR03490.1.
AY333286 mRNA. Translation: AAR03491.1.
AY333287 mRNA. Translation: AAR03492.1.
AY333288 mRNA. Translation: AAR03493.1.
AL354795 Genomic DNA. Translation: CAH70894.1.
CCDSiCCDS55318.1. [Q9BX84-3]
CCDS55319.1. [Q9BX84-2]
CCDS6647.1. [Q9BX84-1]
RefSeqiNP_001170781.1. NM_001177310.1. [Q9BX84-2]
NP_001170782.1. NM_001177311.1. [Q9BX84-3]
NP_060132.3. NM_017662.4. [Q9BX84-1]
UniGeneiHs.272225.

3D structure databases

ProteinModelPortaliQ9BX84.
SMRiQ9BX84.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9BX84. 3 interactors.
MINTiMINT-6699468.
STRINGi9606.ENSP00000354006.

Chemistry databases

BindingDBiQ9BX84.
ChEMBLiCHEMBL1628470.
GuidetoPHARMACOLOGYi498.

Protein family/group databases

TCDBi1.A.4.5.8. the transient receptor potential ca(2+) channel (trp-cc) family.

PTM databases

iPTMnetiQ9BX84.
PhosphoSitePlusiQ9BX84.

Polymorphism and mutation databases

BioMutaiTRPM6.
DMDMi56404951.

Proteomic databases

MaxQBiQ9BX84.
PaxDbiQ9BX84.
PeptideAtlasiQ9BX84.
PRIDEiQ9BX84.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000360774; ENSP00000354006; ENSG00000119121. [Q9BX84-1]
ENST00000361255; ENSP00000354962; ENSG00000119121. [Q9BX84-3]
ENST00000449912; ENSP00000396672; ENSG00000119121. [Q9BX84-2]
GeneIDi140803.
KEGGihsa:140803.
UCSCiuc004ajk.1. human. [Q9BX84-1]

Organism-specific databases

CTDi140803.
DisGeNETi140803.
GeneCardsiTRPM6.
H-InvDBHIX0008102.
HGNCiHGNC:17995. TRPM6.
HPAiHPA007037.
MalaCardsiTRPM6.
MIMi602014. phenotype.
607009. gene.
neXtProtiNX_Q9BX84.
OpenTargetsiENSG00000119121.
Orphaneti30924. Primary hypomagnesemia with secondary hypocalcemia.
PharmGKBiPA38479.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410INBW. Eukaryota.
ENOG410ZSH9. LUCA.
GeneTreeiENSGT00760000119127.
HOGENOMiHOG000230920.
HOVERGENiHBG055663.
InParanoidiQ9BX84.
KOiK04981.
OMAiLMECMVH.
OrthoDBiEOG091G0DHL.
PhylomeDBiQ9BX84.
TreeFamiTF314204.

Enzyme and pathway databases

BioCyciZFISH:HS04275-MONOMER.
ReactomeiR-HSA-3295583. TRP channels.

Miscellaneous databases

GeneWikiiTRPM6.
GenomeRNAii140803.
PROiQ9BX84.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000119121.
CleanExiHS_TRPM6.
ExpressionAtlasiQ9BX84. baseline and differential.
GenevisibleiQ9BX84. HS.

Family and domain databases

InterProiIPR005821. Ion_trans_dom.
IPR011009. Kinase-like_dom.
IPR004166. MHCK_EF2_kinase.
IPR029597. TRPM6.
IPR032415. TRPM_tetra.
[Graphical view]
PANTHERiPTHR13800:SF15. PTHR13800:SF15. 2 hits.
PfamiPF02816. Alpha_kinase. 1 hit.
PF00520. Ion_trans. 1 hit.
PF16519. TRPM_tetra. 1 hit.
[Graphical view]
SMARTiSM00811. Alpha_kinase. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS51158. ALPHA_KINASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTRPM6_HUMAN
AccessioniPrimary (citable) accession number: Q9BX84
Secondary accession number(s): Q6VPR8
, Q6VPR9, Q6VPS0, Q6VPS1, Q6VPS2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 7, 2004
Last sequence update: June 1, 2002
Last modified: November 2, 2016
This is version 135 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.