Q9BX84 (TRPM6_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Transient receptor potential cation channel subfamily M member 6
EC=2.7.11.1

Alternative name(s):
Channel kinase 2
Melastatin-related TRP cation channel 6

Gene names

Name:	TRPM6
Synonyms:	CHAK2

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	2022 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Essential ion channel and serine/threonine-protein kinase. Crucial for magnesium homeostasis. Has an important role in epithelial magnesium transport and in the active magnesium absorption in the gut and kidney. Isoforms of the type M6-kinase lack the ion channel region.
Catalytic activity	ATP + a protein = ADP + a phosphoprotein.
Subunit structure	Forms heterodimers with TRPM7. TRPM6 requires the presence of TRPM7 to be targeted to the cell membrane (in HEK 293 cells). Interacts (via kinase domain) with GNB2L1/RACK1. Ref.3 Ref.5
Subcellular location	Membrane; Multi-pass membrane protein.
Tissue specificity	Highly expressed in kidney and colon. Isoform TRPM6a and isoform TRPM6b, are coexpressed with TRPM7 in kidney, and testis, and are also found in several cell lines of lung origin. Isoform TRPM6c is detected only in testis and in NCI-H510A small cell lung carcinoma cells.
Involvement in disease	Hypomagnesemia 1 (HOMG1) [MIM:602014]: A disorder due to a primary defect in intestinal magnesium absorption. It is characterized by low levels of serum magnesium alongside with a normal renal magnesium secretion, secondary hypocalcemia and calcinocis. Affected individuals show neurologic symptoms of hypomagnesemic hypocalcemia, including seizures and muscle spasms, during infancy. Hypocalcemia is secondary to parathyroid failure resulting from magnesium deficiency. Untreated, the disorder may be fatal or may result in neurological damage. Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.2 Ref.3
Sequence similarities	In the C-terminal section; belongs to the protein kinase superfamily. Alpha-type protein kinase family. ALPK subfamily. In the N-terminal section; belongs to the transient receptor (TC 1.A.4) family. LTrpC subfamily. TRPM6 sub-subfamily. [View classification] Contains 1 alpha-type protein kinase domain.

Ontologies

Keywords
Biological process	Calcium transport Ion transport Transport
Cellular component	Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Disease	Disease mutation Primary hypomagnesemia
Domain	Transmembrane Transmembrane helix
Ligand	ATP-binding Calcium Metal-binding Nucleotide-binding Zinc
Molecular function	Calcium channel Ion channel Kinase Serine/threonine-protein kinase Transferase
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	response to toxin Inferred from direct assay PubMed 17575980. Source: UniProtKB
Cellular_component	apical plasma membrane Inferred from electronic annotation. Source: Compara brush border membrane Inferred from electronic annotation. Source: Compara integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW calcium channel activity Inferred from electronic annotation. Source: UniProtKB-KW metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW protein serine/threonine kinase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 7 isoforms produced by alternative splicing. [Align] [Select]

Isoform TRPM6a (identifier: Q9BX84-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform TRPM6b (identifier: Q9BX84-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-11: MKEQPVLERLQ → MIILSK

Isoform TRPM6c (identifier: Q9BX84-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-11: MKEQPVLERLQ → MTAPVT

Isoform TRPM6t (identifier: Q9BX84-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1926-1943: GVGENLTDPSVIKPEVKQ → ALWFWDSMLKARLGGWRM
     1944-2022: Missing.

Isoform M6-kinase 1 (identifier: Q9BX84-5)

The sequence of this isoform differs from the canonical sequence as follows:
     547-1595: Missing.

Note: Lacks the ion channel region.

Isoform M6-kinase 2 (identifier: Q9BX84-6)

The sequence of this isoform differs from the canonical sequence as follows:
     500-1666: Missing.

Note: Lacks the ion channel region.

Isoform M6-kinase 3 (identifier: Q9BX84-7)

The sequence of this isoform differs from the canonical sequence as follows:
     281-281: R → P
     282-1734: Missing.

Note: Lacks the ion channel region.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 2022	2022	Transient receptor potential cation channel subfamily M member 6		PRO_0000215329
Regions
	Topological domain	1 – 741	741	Cytoplasmic Potential
	Transmembrane	742 – 762	21	Helical; Potential
	Topological domain	763 – 841	79	Extracellular Potential
	Transmembrane	842 – 862	21	Helical; Potential
	Topological domain	863 – 905	43	Cytoplasmic Potential
	Transmembrane	906 – 926	21	Helical; Potential
	Topological domain	927 – 939	13	Extracellular Potential
	Transmembrane	940 – 960	21	Helical; Potential
	Topological domain	961 – 972	12	Cytoplasmic Potential
	Transmembrane	973 – 993	21	Helical; Potential
	Topological domain	994 – 1012	19	Extracellular Potential
	Intramembrane	1013 – 1033	21	Pore-forming; Potential
	Topological domain	1034 – 1047	14	Extracellular Potential
	Transmembrane	1048 – 1068	21	Helical; Potential
	Topological domain	1069 – 2022	954	Cytoplasmic Potential
	Domain	1750 – 1980	231	Alpha-type protein kinase
	Nucleotide binding	1950 – 1956	7	ATP By similarity
Sites
	Active site	1923	1	Proton acceptor By similarity
	Metal binding	1909	1	Zinc By similarity
	Metal binding	1966	1	Zinc By similarity
	Metal binding	1968	1	Zinc By similarity
	Metal binding	1972	1	Zinc By similarity
	Binding site	1780	1	ATP By similarity
	Binding site	1804	1	ATP By similarity
	Binding site	1876	1	ATP By similarity
	Binding site	1925	1	ATP By similarity
	Binding site	1933	1	ATP By similarity
Amino acid modifications
	Modified residue	1851	1	Phosphothreonine; by autocatalysis Ref.5
Natural variations
	Alternative sequence	1 – 11	11	MKEQPVLERLQ → MIILSK in isoform TRPM6b.		VSP_012069
	Alternative sequence	1 – 11	11	MKEQPVLERLQ → MTAPVT in isoform TRPM6c.		VSP_012070
	Alternative sequence	281	1	R → P in isoform M6-kinase 3.		VSP_012071
	Alternative sequence	282 – 1734	1453	Missing in isoform M6-kinase 3.		VSP_012072
	Alternative sequence	500 – 1666	1167	Missing in isoform M6-kinase 2.		VSP_012073
	Alternative sequence	547 – 1595	1049	Missing in isoform M6-kinase 1.		VSP_012074
	Alternative sequence	1926 – 1943	18	GVGEN…PEVKQ → ALWFWDSMLKARLGGWRM in isoform TRPM6t.		VSP_012075
	Alternative sequence	1944 – 2022	79	Missing in isoform TRPM6t.		VSP_012076
	Natural variant	75	1	G → V in a lung adenocarcinoma sample; somatic mutation. Ref.6		VAR_042387
	Natural variant	141	1	S → L in HOMG1; impairs heterodimer formation resulting in intracellular retention. Ref.2 Ref.3		VAR_019963
	Natural variant	338	1	M → I. Ref.6 Corresponds to variant rs56155062 [ dbSNP | Ensembl ].		VAR_042388
	Natural variant	948	1	F → L. Corresponds to variant rs13290391 [ dbSNP | Ensembl ].		VAR_052380
	Natural variant	1007	1	W → C in a lung large cell carcinoma sample; somatic mutation. Ref.6		VAR_042389
	Natural variant	1071	1	N → D. Corresponds to variant rs2274922 [ dbSNP | Ensembl ].		VAR_019964
	Natural variant	1243	1	H → R. Ref.6 Corresponds to variant rs55694430 [ dbSNP | Ensembl ].		VAR_042390
	Natural variant	1274	1	Q → R. Ref.6 Corresponds to variant rs34608911 [ dbSNP | Ensembl ].		VAR_042391
	Natural variant	1393	1	V → I. Ref.6 Corresponds to variant rs3750425 [ dbSNP | Ensembl ].		VAR_019965
	Natural variant	1584	1	K → E. Ref.6 Corresponds to variant rs2274924 [ dbSNP | Ensembl ].		VAR_019966
	Natural variant	1663	1	Q → R. Ref.6 Corresponds to variant rs55679040 [ dbSNP | Ensembl ].		VAR_042392
	Natural variant	1673	1	L → S. Ref.6 Corresponds to variant rs56254742 [ dbSNP | Ensembl ].		VAR_042393
	Natural variant	1724	1	T → I. Ref.6 Corresponds to variant rs56290308 [ dbSNP | Ensembl ].		VAR_042394
Experimental info
	Mutagenesis	1804	1	K → R: Abolishes kinase activity but does not affect expression levels or binding to GNB2L1. Ref.5
	Mutagenesis	1851	1	T → A: Significantly decreases autophosphorylation. Does not alter binding to GNB2L1 but prevents inhibition by GNB2L1. Ref.5
	Mutagenesis	1851	1	T → D: Significantly decreases autophosphorylation. Does not alter binding to GNB2L1 or inhibition by GNB2L1. Ref.5

Sequences

	Sequence		Length	Mass (Da)
	Isoform TRPM6a [UniParc]. Last modified June 1, 2002. Version 2. Checksum: 59346B3BE3300466	FASTA	2,022	231,708
	10 20 30 40 50 60 MKEQPVLERL QSQKSWIKGV FDKRECSTII PSSKNPHRCT PVCQVCQNLI RCYCGRLIGD 70 80 90 100 110 120 HAGIDYSWTI SAAKGKESEQ WSVEKHTTKS PTDTFGTINF QDGEHTHHAK YIRTSYDTKL 130 140 150 160 170 180 DHLLHLMLKE WKMELPKLVI SVHGGIQNFT MPSKFKEIFS QGLVKAAETT GAWIITEGIN 190 200 210 220 230 240 TGVSKHVGDA LKSHSSHSLR KIWTVGIPPW GVIENQRDLI GKDVVCLYQT LDNPLSKLTT 250 260 270 280 290 300 LNSMHSHFIL SDDGTVGKYG NEMKLRRNLE KYLSLQKIHC RSRQGVPVVG LVVEGGPNVI 310 320 330 340 350 360 LSVWETVKDK DPVVVCEGTG RAADLLAFTH KHLADEGMLR PQVKEEIICM IQNTFNFSLK 370 380 390 400 410 420 QSKHLFQILM ECMVHRDCIT IFDADSEEQQ DLDLAILTAL LKGTNLSASE QLNLAMAWDR 430 440 450 460 470 480 VDIAKKHILI YEQHWKPDAL EQAMSDALVM DRVDFVKLLI EYGVNLHRFL TIPRLEELYN 490 500 510 520 530 540 TKQGPTNTLL HHLVQDVKQH TLLSGYRITL IDIGLVVEYL IGRAYRSNYT RKHFRALYNN 550 560 570 580 590 600 LYRKYKHQRH SSGNRNESAE STLHSQFIRT AQPYKFKEKS IVLHKSRKKS KEQNVSDDPE 610 620 630 640 650 660 STGFLYPYND LLVWAVLMKR QKMAMFFWQH GEEATVKAVI ACILYRAMAH EAKESHMVDD 670 680 690 700 710 720 ASEELKNYSK QFGQLALDLL EKAFKQNERM AMTLLTYELR NWSNSTCLKL AVSGGLRPFV 730 740 750 760 770 780 SHTCTQMLLT DMWMGRLKMR KNSWLKIIIS IILPPTILTL EFKSKAEMSH VPQSQDFQFM 790 800 810 820 830 840 WYYSDQNASS SKESASVKEY DLERGHDEKL DENQHFGLES GHQHLPWTRK VYEFYSAPIV 850 860 870 880 890 900 KFWFYTMAYL AFLMLFTYTV LVEMQPQPSV QEWLVSIYIF TNAIEVVREI CISEPGKFTQ 910 920 930 940 950 960 KVKVWISEYW NLTETVAIGL FSAGFVLRWG DPPFHTAGRL IYCIDIIFWF SRLLDFFAVN 970 980 990 1000 1010 1020 QHAGPYVTMI AKMTANMFYI VIIMAIVLLS FGVARKAILS PKEPPSWSLA RDIVFEPYWM 1030 1040 1050 1060 1070 1080 IYGEVYAGEI DVCSSQPSCP PGSFLTPFLQ AVYLFVQYII MVNLLIAFFN NVYLDMESIS 1090 1100 1110 1120 1130 1140 NNLWKYNRYR YIMTYHEKPW LPPPLILLSH VGLLLRRLCC HRAPHDQEEG DVGLKLYLSK 1150 1160 1170 1180 1190 1200 EDLKKLHDFE EQCVEKYFHE KMEDVNCSCE ERIRVTSERV TEMYFQLKEM NEKVSFIKDS 1210 1220 1230 1240 1250 1260 LLSLDSQVGH LQDLSALTVD TLKVLSAVDT LQEDEALLAK RKHSTCKKLP HSWSNVICAE 1270 1280 1290 1300 1310 1320 VLGSMEIAGE KKYQYYSMPS SLLRSLAGGR HPPRVQRGAL LEITNSKREA TNVRNDQERQ 1330 1340 1350 1360 1370 1380 ETQSSIVVSG VSPNRQAHSK YGQFLLVPSN LKRVPFSAET VLPLSRPSVP DVLATEQDIQ 1390 1400 1410 1420 1430 1440 TEVLVHLTGQ TPVVSDWASV DEPKEKHEPI AHLLDGQDKA EQVLPTLSCT PEPMTMSSPL 1450 1460 1470 1480 1490 1500 SQAKIMQTGG GYVNWAFSEG DETGVFSIKK KWQTCLPSTC DSDSSRSEQH QKQAQDSSLS 1510 1520 1530 1540 1550 1560 DNSTRSAQSS ECSEVGPWLQ PNTSFWINPL RRYRPFARSH SFRFHKEEKL MKICKIKNLS 1570 1580 1590 1600 1610 1620 GSSEIGQGAW VKAKMLTKDR RLSKKKKNTQ GLQVPIITVN ACSQSDQLNP EPGENSISEE 1630 1640 1650 1660 1670 1680 EYSKNWFTVS KFSHTGVEPY IHQKMKTKEI GQCAIQISDY LKQSQEDLSK NSLWNSRSTN 1690 1700 1710 1720 1730 1740 LNRNSLLKSS IGVDKISASL KSPQEPHHHY SAIERNNLMR LSQTIPFTPV QLFAGEEITV 1750 1760 1770 1780 1790 1800 YRLEESSPLN LDKSMSSWSQ RGRAAMIQVL SREEMDGGLR KAMRVVSTWS EDDILKPGQV 1810 1820 1830 1840 1850 1860 FIVKSFLPEV VRTWHKIFQE STVLHLCLRE IQQQRAAQKL IYTFNQVKPQ TIPYTPRFLE 1870 1880 1890 1900 1910 1920 VFLIYCHSAN QWLTIEKYMT GEFRKYNNNN GDEITPTNTL EELMLAFSHW TYEYTRGELL 1930 1940 1950 1960 1970 1980 VLDLQGVGEN LTDPSVIKPE VKQSRGMVFG PANLGEDAIR NFIAKHHCNS CCRKLKLPDL 1990 2000 2010 2020 KRNDYSPERI NSTFGLEIKI ESAEEPPARE TGRNSPEDDM QL
	Isoform TRPM6b [UniParc]. Checksum: C96D328F3E9B2A9E	FASTA	2,017	231,041
	10 20 30 40 50 60 MIILSKSQKS WIKGVFDKRE CSTIIPSSKN PHRCTPVCQV CQNLIRCYCG RLIGDHAGID 70 80 90 100 110 120 YSWTISAAKG KESEQWSVEK HTTKSPTDTF GTINFQDGEH THHAKYIRTS YDTKLDHLLH 130 140 150 160 170 180 LMLKEWKMEL PKLVISVHGG IQNFTMPSKF KEIFSQGLVK AAETTGAWII TEGINTGVSK 190 200 210 220 230 240 HVGDALKSHS SHSLRKIWTV GIPPWGVIEN QRDLIGKDVV CLYQTLDNPL SKLTTLNSMH 250 260 270 280 290 300 SHFILSDDGT VGKYGNEMKL RRNLEKYLSL QKIHCRSRQG VPVVGLVVEG GPNVILSVWE 310 320 330 340 350 360 TVKDKDPVVV CEGTGRAADL LAFTHKHLAD EGMLRPQVKE EIICMIQNTF NFSLKQSKHL 370 380 390 400 410 420 FQILMECMVH RDCITIFDAD SEEQQDLDLA ILTALLKGTN LSASEQLNLA MAWDRVDIAK 430 440 450 460 470 480 KHILIYEQHW KPDALEQAMS DALVMDRVDF VKLLIEYGVN LHRFLTIPRL EELYNTKQGP 490 500 510 520 530 540 TNTLLHHLVQ DVKQHTLLSG YRITLIDIGL VVEYLIGRAY RSNYTRKHFR ALYNNLYRKY 550 560 570 580 590 600 KHQRHSSGNR NESAESTLHS QFIRTAQPYK FKEKSIVLHK SRKKSKEQNV SDDPESTGFL 610 620 630 640 650 660 YPYNDLLVWA VLMKRQKMAM FFWQHGEEAT VKAVIACILY RAMAHEAKES HMVDDASEEL 670 680 690 700 710 720 KNYSKQFGQL ALDLLEKAFK QNERMAMTLL TYELRNWSNS TCLKLAVSGG LRPFVSHTCT 730 740 750 760 770 780 QMLLTDMWMG RLKMRKNSWL KIIISIILPP TILTLEFKSK AEMSHVPQSQ DFQFMWYYSD 790 800 810 820 830 840 QNASSSKESA SVKEYDLERG HDEKLDENQH FGLESGHQHL PWTRKVYEFY SAPIVKFWFY 850 860 870 880 890 900 TMAYLAFLML FTYTVLVEMQ PQPSVQEWLV SIYIFTNAIE VVREICISEP GKFTQKVKVW 910 920 930 940 950 960 ISEYWNLTET VAIGLFSAGF VLRWGDPPFH TAGRLIYCID IIFWFSRLLD FFAVNQHAGP 970 980 990 1000 1010 1020 YVTMIAKMTA NMFYIVIIMA IVLLSFGVAR KAILSPKEPP SWSLARDIVF EPYWMIYGEV 1030 1040 1050 1060 1070 1080 YAGEIDVCSS QPSCPPGSFL TPFLQAVYLF VQYIIMVNLL IAFFNNVYLD MESISNNLWK 1090 1100 1110 1120 1130 1140 YNRYRYIMTY HEKPWLPPPL ILLSHVGLLL RRLCCHRAPH DQEEGDVGLK LYLSKEDLKK 1150 1160 1170 1180 1190 1200 LHDFEEQCVE KYFHEKMEDV NCSCEERIRV TSERVTEMYF QLKEMNEKVS FIKDSLLSLD 1210 1220 1230 1240 1250 1260 SQVGHLQDLS ALTVDTLKVL SAVDTLQEDE ALLAKRKHST CKKLPHSWSN VICAEVLGSM 1270 1280 1290 1300 1310 1320 EIAGEKKYQY YSMPSSLLRS LAGGRHPPRV QRGALLEITN SKREATNVRN DQERQETQSS 1330 1340 1350 1360 1370 1380 IVVSGVSPNR QAHSKYGQFL LVPSNLKRVP FSAETVLPLS RPSVPDVLAT EQDIQTEVLV 1390 1400 1410 1420 1430 1440 HLTGQTPVVS DWASVDEPKE KHEPIAHLLD GQDKAEQVLP TLSCTPEPMT MSSPLSQAKI 1450 1460 1470 1480 1490 1500 MQTGGGYVNW AFSEGDETGV FSIKKKWQTC LPSTCDSDSS RSEQHQKQAQ DSSLSDNSTR 1510 1520 1530 1540 1550 1560 SAQSSECSEV GPWLQPNTSF WINPLRRYRP FARSHSFRFH KEEKLMKICK IKNLSGSSEI 1570 1580 1590 1600 1610 1620 GQGAWVKAKM LTKDRRLSKK KKNTQGLQVP IITVNACSQS DQLNPEPGEN SISEEEYSKN 1630 1640 1650 1660 1670 1680 WFTVSKFSHT GVEPYIHQKM KTKEIGQCAI QISDYLKQSQ EDLSKNSLWN SRSTNLNRNS 1690 1700 1710 1720 1730 1740 LLKSSIGVDK ISASLKSPQE PHHHYSAIER NNLMRLSQTI PFTPVQLFAG EEITVYRLEE 1750 1760 1770 1780 1790 1800 SSPLNLDKSM SSWSQRGRAA MIQVLSREEM DGGLRKAMRV VSTWSEDDIL KPGQVFIVKS 1810 1820 1830 1840 1850 1860 FLPEVVRTWH KIFQESTVLH LCLREIQQQR AAQKLIYTFN QVKPQTIPYT PRFLEVFLIY 1870 1880 1890 1900 1910 1920 CHSANQWLTI EKYMTGEFRK YNNNNGDEIT PTNTLEELML AFSHWTYEYT RGELLVLDLQ 1930 1940 1950 1960 1970 1980 GVGENLTDPS VIKPEVKQSR GMVFGPANLG EDAIRNFIAK HHCNSCCRKL KLPDLKRNDY 1990 2000 2010 SPERINSTFG LEIKIESAEE PPARETGRNS PEDDMQL
	Isoform TRPM6c [UniParc]. Checksum: 7F49198CADF3F64D	FASTA	2,017	230,956
	10 20 30 40 50 60 MTAPVTSQKS WIKGVFDKRE CSTIIPSSKN PHRCTPVCQV CQNLIRCYCG RLIGDHAGID 70 80 90 100 110 120 YSWTISAAKG KESEQWSVEK HTTKSPTDTF GTINFQDGEH THHAKYIRTS YDTKLDHLLH 130 140 150 160 170 180 LMLKEWKMEL PKLVISVHGG IQNFTMPSKF KEIFSQGLVK AAETTGAWII TEGINTGVSK 190 200 210 220 230 240 HVGDALKSHS SHSLRKIWTV GIPPWGVIEN QRDLIGKDVV CLYQTLDNPL SKLTTLNSMH 250 260 270 280 290 300 SHFILSDDGT VGKYGNEMKL RRNLEKYLSL QKIHCRSRQG VPVVGLVVEG GPNVILSVWE 310 320 330 340 350 360 TVKDKDPVVV CEGTGRAADL LAFTHKHLAD EGMLRPQVKE EIICMIQNTF NFSLKQSKHL 370 380 390 400 410 420 FQILMECMVH RDCITIFDAD SEEQQDLDLA ILTALLKGTN LSASEQLNLA MAWDRVDIAK 430 440 450 460 470 480 KHILIYEQHW KPDALEQAMS DALVMDRVDF VKLLIEYGVN LHRFLTIPRL EELYNTKQGP 490 500 510 520 530 540 TNTLLHHLVQ DVKQHTLLSG YRITLIDIGL VVEYLIGRAY RSNYTRKHFR ALYNNLYRKY 550 560 570 580 590 600 KHQRHSSGNR NESAESTLHS QFIRTAQPYK FKEKSIVLHK SRKKSKEQNV SDDPESTGFL 610 620 630 640 650 660 YPYNDLLVWA VLMKRQKMAM FFWQHGEEAT VKAVIACILY RAMAHEAKES HMVDDASEEL 670 680 690 700 710 720 KNYSKQFGQL ALDLLEKAFK QNERMAMTLL TYELRNWSNS TCLKLAVSGG LRPFVSHTCT 730 740 750 760 770 780 QMLLTDMWMG RLKMRKNSWL KIIISIILPP TILTLEFKSK AEMSHVPQSQ DFQFMWYYSD 790 800 810 820 830 840 QNASSSKESA SVKEYDLERG HDEKLDENQH FGLESGHQHL PWTRKVYEFY SAPIVKFWFY 850 860 870 880 890 900 TMAYLAFLML FTYTVLVEMQ PQPSVQEWLV SIYIFTNAIE VVREICISEP GKFTQKVKVW 910 920 930 940 950 960 ISEYWNLTET VAIGLFSAGF VLRWGDPPFH TAGRLIYCID IIFWFSRLLD FFAVNQHAGP 970 980 990 1000 1010 1020 YVTMIAKMTA NMFYIVIIMA IVLLSFGVAR KAILSPKEPP SWSLARDIVF EPYWMIYGEV 1030 1040 1050 1060 1070 1080 YAGEIDVCSS QPSCPPGSFL TPFLQAVYLF VQYIIMVNLL IAFFNNVYLD MESISNNLWK 1090 1100 1110 1120 1130 1140 YNRYRYIMTY HEKPWLPPPL ILLSHVGLLL RRLCCHRAPH DQEEGDVGLK LYLSKEDLKK 1150 1160 1170 1180 1190 1200 LHDFEEQCVE KYFHEKMEDV NCSCEERIRV TSERVTEMYF QLKEMNEKVS FIKDSLLSLD 1210 1220 1230 1240 1250 1260 SQVGHLQDLS ALTVDTLKVL SAVDTLQEDE ALLAKRKHST CKKLPHSWSN VICAEVLGSM 1270 1280 1290 1300 1310 1320 EIAGEKKYQY YSMPSSLLRS LAGGRHPPRV QRGALLEITN SKREATNVRN DQERQETQSS 1330 1340 1350 1360 1370 1380 IVVSGVSPNR QAHSKYGQFL LVPSNLKRVP FSAETVLPLS RPSVPDVLAT EQDIQTEVLV 1390 1400 1410 1420 1430 1440 HLTGQTPVVS DWASVDEPKE KHEPIAHLLD GQDKAEQVLP TLSCTPEPMT MSSPLSQAKI 1450 1460 1470 1480 1490 1500 MQTGGGYVNW AFSEGDETGV FSIKKKWQTC LPSTCDSDSS RSEQHQKQAQ DSSLSDNSTR 1510 1520 1530 1540 1550 1560 SAQSSECSEV GPWLQPNTSF WINPLRRYRP FARSHSFRFH KEEKLMKICK IKNLSGSSEI 1570 1580 1590 1600 1610 1620 GQGAWVKAKM LTKDRRLSKK KKNTQGLQVP IITVNACSQS DQLNPEPGEN SISEEEYSKN 1630 1640 1650 1660 1670 1680 WFTVSKFSHT GVEPYIHQKM KTKEIGQCAI QISDYLKQSQ EDLSKNSLWN SRSTNLNRNS 1690 1700 1710 1720 1730 1740 LLKSSIGVDK ISASLKSPQE PHHHYSAIER NNLMRLSQTI PFTPVQLFAG EEITVYRLEE 1750 1760 1770 1780 1790 1800 SSPLNLDKSM SSWSQRGRAA MIQVLSREEM DGGLRKAMRV VSTWSEDDIL KPGQVFIVKS 1810 1820 1830 1840 1850 1860 FLPEVVRTWH KIFQESTVLH LCLREIQQQR AAQKLIYTFN QVKPQTIPYT PRFLEVFLIY 1870 1880 1890 1900 1910 1920 CHSANQWLTI EKYMTGEFRK YNNNNGDEIT PTNTLEELML AFSHWTYEYT RGELLVLDLQ 1930 1940 1950 1960 1970 1980 GVGENLTDPS VIKPEVKQSR GMVFGPANLG EDAIRNFIAK HHCNSCCRKL KLPDLKRNDY 1990 2000 2010 SPERINSTFG LEIKIESAEE PPARETGRNS PEDDMQL
	Isoform TRPM6t [UniParc]. Checksum: 15F59730C0F345EC	FASTA	1,943	223,124
	10 20 30 40 50 60 MKEQPVLERL QSQKSWIKGV FDKRECSTII PSSKNPHRCT PVCQVCQNLI RCYCGRLIGD 70 80 90 100 110 120 HAGIDYSWTI SAAKGKESEQ WSVEKHTTKS PTDTFGTINF QDGEHTHHAK YIRTSYDTKL 130 140 150 160 170 180 DHLLHLMLKE WKMELPKLVI SVHGGIQNFT MPSKFKEIFS QGLVKAAETT GAWIITEGIN 190 200 210 220 230 240 TGVSKHVGDA LKSHSSHSLR KIWTVGIPPW GVIENQRDLI GKDVVCLYQT LDNPLSKLTT 250 260 270 280 290 300 LNSMHSHFIL SDDGTVGKYG NEMKLRRNLE KYLSLQKIHC RSRQGVPVVG LVVEGGPNVI 310 320 330 340 350 360 LSVWETVKDK DPVVVCEGTG RAADLLAFTH KHLADEGMLR PQVKEEIICM IQNTFNFSLK 370 380 390 400 410 420 QSKHLFQILM ECMVHRDCIT IFDADSEEQQ DLDLAILTAL LKGTNLSASE QLNLAMAWDR 430 440 450 460 470 480 VDIAKKHILI YEQHWKPDAL EQAMSDALVM DRVDFVKLLI EYGVNLHRFL TIPRLEELYN 490 500 510 520 530 540 TKQGPTNTLL HHLVQDVKQH TLLSGYRITL IDIGLVVEYL IGRAYRSNYT RKHFRALYNN 550 560 570 580 590 600 LYRKYKHQRH SSGNRNESAE STLHSQFIRT AQPYKFKEKS IVLHKSRKKS KEQNVSDDPE 610 620 630 640 650 660 STGFLYPYND LLVWAVLMKR QKMAMFFWQH GEEATVKAVI ACILYRAMAH EAKESHMVDD 670 680 690 700 710 720 ASEELKNYSK QFGQLALDLL EKAFKQNERM AMTLLTYELR NWSNSTCLKL AVSGGLRPFV 730 740 750 760 770 780 SHTCTQMLLT DMWMGRLKMR KNSWLKIIIS IILPPTILTL EFKSKAEMSH VPQSQDFQFM 790 800 810 820 830 840 WYYSDQNASS SKESASVKEY DLERGHDEKL DENQHFGLES GHQHLPWTRK VYEFYSAPIV 850 860 870 880 890 900 KFWFYTMAYL AFLMLFTYTV LVEMQPQPSV QEWLVSIYIF TNAIEVVREI CISEPGKFTQ 910 920 930 940 950 960 KVKVWISEYW NLTETVAIGL FSAGFVLRWG DPPFHTAGRL IYCIDIIFWF SRLLDFFAVN 970 980 990 1000 1010 1020 QHAGPYVTMI AKMTANMFYI VIIMAIVLLS FGVARKAILS PKEPPSWSLA RDIVFEPYWM 1030 1040 1050 1060 1070 1080 IYGEVYAGEI DVCSSQPSCP PGSFLTPFLQ AVYLFVQYII MVNLLIAFFN NVYLDMESIS 1090 1100 1110 1120 1130 1140 NNLWKYNRYR YIMTYHEKPW LPPPLILLSH VGLLLRRLCC HRAPHDQEEG DVGLKLYLSK 1150 1160 1170 1180 1190 1200 EDLKKLHDFE EQCVEKYFHE KMEDVNCSCE ERIRVTSERV TEMYFQLKEM NEKVSFIKDS 1210 1220 1230 1240 1250 1260 LLSLDSQVGH LQDLSALTVD TLKVLSAVDT LQEDEALLAK RKHSTCKKLP HSWSNVICAE 1270 1280 1290 1300 1310 1320 VLGSMEIAGE KKYQYYSMPS SLLRSLAGGR HPPRVQRGAL LEITNSKREA TNVRNDQERQ 1330 1340 1350 1360 1370 1380 ETQSSIVVSG VSPNRQAHSK YGQFLLVPSN LKRVPFSAET VLPLSRPSVP DVLATEQDIQ 1390 1400 1410 1420 1430 1440 TEVLVHLTGQ TPVVSDWASV DEPKEKHEPI AHLLDGQDKA EQVLPTLSCT PEPMTMSSPL 1450 1460 1470 1480 1490 1500 SQAKIMQTGG GYVNWAFSEG DETGVFSIKK KWQTCLPSTC DSDSSRSEQH QKQAQDSSLS 1510 1520 1530 1540 1550 1560 DNSTRSAQSS ECSEVGPWLQ PNTSFWINPL RRYRPFARSH SFRFHKEEKL MKICKIKNLS 1570 1580 1590 1600 1610 1620 GSSEIGQGAW VKAKMLTKDR RLSKKKKNTQ GLQVPIITVN ACSQSDQLNP EPGENSISEE 1630 1640 1650 1660 1670 1680 EYSKNWFTVS KFSHTGVEPY IHQKMKTKEI GQCAIQISDY LKQSQEDLSK NSLWNSRSTN 1690 1700 1710 1720 1730 1740 LNRNSLLKSS IGVDKISASL KSPQEPHHHY SAIERNNLMR LSQTIPFTPV QLFAGEEITV 1750 1760 1770 1780 1790 1800 YRLEESSPLN LDKSMSSWSQ RGRAAMIQVL SREEMDGGLR KAMRVVSTWS EDDILKPGQV 1810 1820 1830 1840 1850 1860 FIVKSFLPEV VRTWHKIFQE STVLHLCLRE IQQQRAAQKL IYTFNQVKPQ TIPYTPRFLE 1870 1880 1890 1900 1910 1920 VFLIYCHSAN QWLTIEKYMT GEFRKYNNNN GDEITPTNTL EELMLAFSHW TYEYTRGELL 1930 1940 VLDLQALWFW DSMLKARLGG WRM
	Isoform M6-kinase 1 [UniParc]. Checksum: 4B6503C01BF3F3B6	FASTA	973	111,301
	10 20 30 40 50 60 MKEQPVLERL QSQKSWIKGV FDKRECSTII PSSKNPHRCT PVCQVCQNLI RCYCGRLIGD 70 80 90 100 110 120 HAGIDYSWTI SAAKGKESEQ WSVEKHTTKS PTDTFGTINF QDGEHTHHAK YIRTSYDTKL 130 140 150 160 170 180 DHLLHLMLKE WKMELPKLVI SVHGGIQNFT MPSKFKEIFS QGLVKAAETT GAWIITEGIN 190 200 210 220 230 240 TGVSKHVGDA LKSHSSHSLR KIWTVGIPPW GVIENQRDLI GKDVVCLYQT LDNPLSKLTT 250 260 270 280 290 300 LNSMHSHFIL SDDGTVGKYG NEMKLRRNLE KYLSLQKIHC RSRQGVPVVG LVVEGGPNVI 310 320 330 340 350 360 LSVWETVKDK DPVVVCEGTG RAADLLAFTH KHLADEGMLR PQVKEEIICM IQNTFNFSLK 370 380 390 400 410 420 QSKHLFQILM ECMVHRDCIT IFDADSEEQQ DLDLAILTAL LKGTNLSASE QLNLAMAWDR 430 440 450 460 470 480 VDIAKKHILI YEQHWKPDAL EQAMSDALVM DRVDFVKLLI EYGVNLHRFL TIPRLEELYN 490 500 510 520 530 540 TKQGPTNTLL HHLVQDVKQH TLLSGYRITL IDIGLVVEYL IGRAYRSNYT RKHFRALYNN 550 560 570 580 590 600 LYRKYKIITV NACSQSDQLN PEPGENSISE EEYSKNWFTV SKFSHTGVEP YIHQKMKTKE 610 620 630 640 650 660 IGQCAIQISD YLKQSQEDLS KNSLWNSRST NLNRNSLLKS SIGVDKISAS LKSPQEPHHH 670 680 690 700 710 720 YSAIERNNLM RLSQTIPFTP VQLFAGEEIT VYRLEESSPL NLDKSMSSWS QRGRAAMIQV 730 740 750 760 770 780 LSREEMDGGL RKAMRVVSTW SEDDILKPGQ VFIVKSFLPE VVRTWHKIFQ ESTVLHLCLR 790 800 810 820 830 840 EIQQQRAAQK LIYTFNQVKP QTIPYTPRFL EVFLIYCHSA NQWLTIEKYM TGEFRKYNNN 850 860 870 880 890 900 NGDEITPTNT LEELMLAFSH WTYEYTRGEL LVLDLQGVGE NLTDPSVIKP EVKQSRGMVF 910 920 930 940 950 960 GPANLGEDAI RNFIAKHHCN SCCRKLKLPD LKRNDYSPER INSTFGLEIK IESAEEPPAR 970 ETGRNSPEDD MQL
	Isoform M6-kinase 2 [UniParc]. Checksum: 924C00E589E6FED0	FASTA	855	97,520
	10 20 30 40 50 60 MKEQPVLERL QSQKSWIKGV FDKRECSTII PSSKNPHRCT PVCQVCQNLI RCYCGRLIGD 70 80 90 100 110 120 HAGIDYSWTI SAAKGKESEQ WSVEKHTTKS PTDTFGTINF QDGEHTHHAK YIRTSYDTKL 130 140 150 160 170 180 DHLLHLMLKE WKMELPKLVI SVHGGIQNFT MPSKFKEIFS QGLVKAAETT GAWIITEGIN 190 200 210 220 230 240 TGVSKHVGDA LKSHSSHSLR KIWTVGIPPW GVIENQRDLI GKDVVCLYQT LDNPLSKLTT 250 260 270 280 290 300 LNSMHSHFIL SDDGTVGKYG NEMKLRRNLE KYLSLQKIHC RSRQGVPVVG LVVEGGPNVI 310 320 330 340 350 360 LSVWETVKDK DPVVVCEGTG RAADLLAFTH KHLADEGMLR PQVKEEIICM IQNTFNFSLK 370 380 390 400 410 420 QSKHLFQILM ECMVHRDCIT IFDADSEEQQ DLDLAILTAL LKGTNLSASE QLNLAMAWDR 430 440 450 460 470 480 VDIAKKHILI YEQHWKPDAL EQAMSDALVM DRVDFVKLLI EYGVNLHRFL TIPRLEELYN 490 500 510 520 530 540 TKQGPTNTLL HHLVQDVKQD LSKNSLWNSR STNLNRNSLL KSSIGVDKIS ASLKSPQEPH 550 560 570 580 590 600 HHYSAIERNN LMRLSQTIPF TPVQLFAGEE ITVYRLEESS PLNLDKSMSS WSQRGRAAMI 610 620 630 640 650 660 QVLSREEMDG GLRKAMRVVS TWSEDDILKP GQVFIVKSFL PEVVRTWHKI FQESTVLHLC 670 680 690 700 710 720 LREIQQQRAA QKLIYTFNQV KPQTIPYTPR FLEVFLIYCH SANQWLTIEK YMTGEFRKYN 730 740 750 760 770 780 NNNGDEITPT NTLEELMLAF SHWTYEYTRG ELLVLDLQGV GENLTDPSVI KPEVKQSRGM 790 800 810 820 830 840 VFGPANLGED AIRNFIAKHH CNSCCRKLKL PDLKRNDYSP ERINSTFGLE IKIESAEEPP 850 ARETGRNSPE DDMQL
	Isoform M6-kinase 3 [UniParc]. Checksum: 7BF7F1E5163459EF	FASTA	569	65,083
	10 20 30 40 50 60 MKEQPVLERL QSQKSWIKGV FDKRECSTII PSSKNPHRCT PVCQVCQNLI RCYCGRLIGD 70 80 90 100 110 120 HAGIDYSWTI SAAKGKESEQ WSVEKHTTKS PTDTFGTINF QDGEHTHHAK YIRTSYDTKL 130 140 150 160 170 180 DHLLHLMLKE WKMELPKLVI SVHGGIQNFT MPSKFKEIFS QGLVKAAETT GAWIITEGIN 190 200 210 220 230 240 TGVSKHVGDA LKSHSSHSLR KIWTVGIPPW GVIENQRDLI GKDVVCLYQT LDNPLSKLTT 250 260 270 280 290 300 LNSMHSHFIL SDDGTVGKYG NEMKLRRNLE KYLSLQKIHC PGEEITVYRL EESSPLNLDK 310 320 330 340 350 360 SMSSWSQRGR AAMIQVLSRE EMDGGLRKAM RVVSTWSEDD ILKPGQVFIV KSFLPEVVRT 370 380 390 400 410 420 WHKIFQESTV LHLCLREIQQ QRAAQKLIYT FNQVKPQTIP YTPRFLEVFL IYCHSANQWL 430 440 450 460 470 480 TIEKYMTGEF RKYNNNNGDE ITPTNTLEEL MLAFSHWTYE YTRGELLVLD LQGVGENLTD 490 500 510 520 530 540 PSVIKPEVKQ SRGMVFGPAN LGEDAIRNFI AKHHCNSCCR KLKLPDLKRN DYSPERINST 550 560 FGLEIKIESA EEPPARETGR NSPEDDMQL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Novel type of signaling molecules: protein kinases covalently linked to ion channels." Riazanova L.V., Pavur K.S., Petrov A.N., Dorovkov M.V., Riazanov A.G. Mol. Biol. (Mosk.) 35:321-332(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM TRPM6A), CHARACTERIZATION. Tissue: Kidney.
[2]	"Hypomagnesemia with secondary hypocalcemia is caused by mutations in TRPM6, a new member of the TRPM gene family." Schlingmann K.P., Weber S., Peters M., Niemann Nejsum L.N., Vitzthum H., Klingel K., Kratz M., Haddad E., Ristoff E., Dinour D., Syrrou M., Nielsen S., Sassen M.C., Waldegger S., Seyberth H.W., Konrad M. Nat. Genet. 31:166-170(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM TRPM6A), VARIANT HOMG1 LEU-141. Tissue: Kidney and Small intestine.
[3]	"Disruption of TRPM6/TRPM7 complex formation by a mutation in the TRPM6 gene causes hypomagnesemia with secondary hypocalcemia." Chubanov V., Waldegger S., Mederos y Schnitzler M., Vitzthum H., Sassen M.C., Seyberth H.W., Konrad M., Gudermann T. Proc. Natl. Acad. Sci. U.S.A. 101:2894-2899(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS TRPM6A; TRPM6B; TRPM6C; TRPM6T; M6-KINASE 1; M6-KINASE 2 AND M6-KINASE 3), CHARACTERIZATION OF VARIANT HOMG1 LEU-141, INTERACTION WITH TRPM7. Tissue: Lung cancer.
[4]	"DNA sequence and analysis of human chromosome 9." Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L. , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I. Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"RACK1 inhibits TRPM6 activity via phosphorylation of the fused alpha-kinase domain." Cao G., Thebault S., van der Wijst J., van der Kemp A., Lasonder E., Bindels R.J., Hoenderop J.G. Curr. Biol. 18:168-176(2008) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH GNB2L1, PHOSPHORYLATION AT THR-1851, MUTAGENESIS OF LYS-1804 AND THR-1851.
[6]	"Patterns of somatic mutation in human cancer genomes." Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G. , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R. Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANTS [LARGE SCALE ANALYSIS] VAL-75; ILE-338; CYS-1007; ARG-1243; ARG-1274; ILE-1393; GLU-1584; ARG-1663; SER-1673 AND ILE-1724.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF350881 mRNA. Translation: AAK31202.2. AF448232 mRNA. Translation: AAM21562.1. AY333282 mRNA. Translation: AAR03487.1. AY333283 mRNA. Translation: AAR03488.1. AY333284 mRNA. Translation: AAR03489.1. AY333285 mRNA. Translation: AAR03490.1. AY333286 mRNA. Translation: AAR03491.1. AY333287 mRNA. Translation: AAR03492.1. AY333288 mRNA. Translation: AAR03493.1. AL354795 Genomic DNA. Translation: CAH70894.1.
IPI	IPI00151366. IPI00438874. IPI00438875. IPI00438890. IPI00472524. IPI00478589. IPI00479402.
RefSeq	NP_001170781.1. NM_001177310.1. NP_001170782.1. NM_001177311.1. NP_060132.3. NM_017662.4.
UniGene	Hs.272225.
3D structure databases
ProteinModelPortal	Q9BX84.
ModBase	Search...
Protein-protein interaction databases
MINT	MINT-6699468.
STRING	9606.ENSP00000354006.
Protein family/group databases
TCDB	1.A.4.5.8. transient receptor potential Ca2+ channel (TRP-CC) family.
PTM databases
PhosphoSite	Q9BX84.
Polymorphism databases
DMDM	56404951.
Proteomic databases
PaxDb	Q9BX84.
PRIDE	Q9BX84.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000360774; ENSP00000354006; ENSG00000119121. ENST00000361255; ENSP00000354962; ENSG00000119121. ENST00000449912; ENSP00000396672; ENSG00000119121.
GeneID	140803.
KEGG	hsa:140803.
UCSC	uc004ajk.1. human. uc004ajl.1. human. uc010mpc.1. human. uc010mpd.1. human. uc010mpe.1. human. uc022bib.1. human.
Organism-specific databases
CTD	140803.
GeneCards	GC09M077337.
H-InvDB	HIX0008102.
HGNC	HGNC:17995. TRPM6.
HPA	HPA007037.
MIM	602014. phenotype. 607009. gene.
neXtProt	NX_Q9BX84.
Orphanet	30924. Hypomagnesemia caused by selective magnesium malabsorption.
PharmGKB	PA38479.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG253824.
HOGENOM	HOG000230920.
HOVERGEN	HBG055663.
KO	K04981.
OrthoDB	EOG4SN1MT.
Gene expression databases
ArrayExpress	Q9BX84.
Bgee	Q9BX84.
CleanEx	HS_TRPM6.
Genevestigator	Q9BX84.
GermOnline	ENSG00000119121. Homo sapiens.
Family and domain databases
InterPro	IPR005821. Ion_trans_dom. IPR011009. Kinase-like_dom. IPR004166. MHCK_EF2_kinase. [Graphical view]
Pfam	PF02816. Alpha_kinase. 1 hit. PF00520. Ion_trans. 1 hit. [Graphical view]
SMART	SM00811. Alpha_kinase. 1 hit. [Graphical view]
SUPFAM	SSF56112. Kinase_like. 1 hit.
PROSITE	PS51158. ALPHA_KINASE. 1 hit. [Graphical view]
ProtoNet	Search...
Other
BindingDB	Q9BX84.
ChEMBL	CHEMBL1628470.
GenomeRNAi	140803.
NextBio	84406.
SOURCE	Search...

Entry information

Entry name

TRPM6_HUMAN

Accession

Primary (citable) accession number: Q9BX84
Secondary accession number(s): Q6VPR8 , Q6VPR9, Q6VPS0, Q6VPS1, Q6VPS2

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 7, 2004
Last sequence update:	June 1, 2002
Last modified:	May 1, 2013
This is version 102 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.