Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q9BX84 (TRPM6_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 113. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Transient receptor potential cation channel subfamily M member 6

EC=2.7.11.1
Alternative name(s):
Channel kinase 2
Melastatin-related TRP cation channel 6
Gene names
Name:TRPM6
Synonyms:CHAK2
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length2022 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Essential ion channel and serine/threonine-protein kinase. Crucial for magnesium homeostasis. Has an important role in epithelial magnesium transport and in the active magnesium absorption in the gut and kidney. Isoforms of the type M6-kinase lack the ion channel region.

Catalytic activity

ATP + a protein = ADP + a phosphoprotein.

Subunit structure

Forms heterodimers with TRPM7. TRPM6 requires the presence of TRPM7 to be targeted to the cell membrane (in HEK 293 cells). Interacts (via kinase domain) with GNB2L1/RACK1. Ref.3 Ref.5

Subcellular location

Membrane; Multi-pass membrane protein.

Tissue specificity

Highly expressed in kidney and colon. Isoform TRPM6a and isoform TRPM6b, are coexpressed with TRPM7 in kidney, and testis, and are also found in several cell lines of lung origin. Isoform TRPM6c is detected only in testis and in NCI-H510A small cell lung carcinoma cells.

Involvement in disease

Hypomagnesemia 1 (HOMG1) [MIM:602014]: A disorder due to a primary defect in intestinal magnesium absorption. It is characterized by low levels of serum magnesium alongside with a normal renal magnesium secretion, secondary hypocalcemia and calcinocis. Affected individuals show neurologic symptoms of hypomagnesemic hypocalcemia, including seizures and muscle spasms, during infancy. Hypocalcemia is secondary to parathyroid failure resulting from magnesium deficiency. Untreated, the disorder may be fatal or may result in neurological damage.
Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.2 Ref.3

Sequence similarities

In the C-terminal section; belongs to the protein kinase superfamily. Alpha-type protein kinase family. ALPK subfamily.

In the N-terminal section; belongs to the transient receptor (TC 1.A.4) family. LTrpC subfamily. TRPM6 sub-subfamily. [View classification]

Contains 1 alpha-type protein kinase domain.

Ontologies

Keywords
   Biological processCalcium transport
Ion transport
Transport
   Cellular componentMembrane
   Coding sequence diversityAlternative splicing
Polymorphism
   DiseaseDisease mutation
Primary hypomagnesemia
   DomainTransmembrane
Transmembrane helix
   LigandATP-binding
Calcium
Metal-binding
Nucleotide-binding
Zinc
   Molecular functionCalcium channel
Ion channel
Kinase
Serine/threonine-protein kinase
Transferase
   PTMPhosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcalcium ion transmembrane transport

Traceable author statement. Source: Reactome

ion transmembrane transport

Traceable author statement. Source: Reactome

response to toxic substance

Inferred from direct assay PubMed 17575980. Source: UniProtKB

transmembrane transport

Traceable author statement. Source: Reactome

   Cellular_componentapical plasma membrane

Inferred from electronic annotation. Source: Ensembl

brush border membrane

Inferred from electronic annotation. Source: Ensembl

integral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

plasma membrane

Traceable author statement. Source: Reactome

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

calcium channel activity

Inferred from electronic annotation. Source: UniProtKB-KW

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

protein serine/threonine kinase activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Alternative products

This entry describes 7 isoforms produced by alternative splicing. [Align] [Select]
Isoform TRPM6a (identifier: Q9BX84-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform TRPM6b (identifier: Q9BX84-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-11: MKEQPVLERLQ → MIILSK
Isoform TRPM6c (identifier: Q9BX84-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-11: MKEQPVLERLQ → MTAPVT
Isoform TRPM6t (identifier: Q9BX84-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1926-1943: GVGENLTDPSVIKPEVKQ → ALWFWDSMLKARLGGWRM
     1944-2022: Missing.
Isoform M6-kinase 1 (identifier: Q9BX84-5)

The sequence of this isoform differs from the canonical sequence as follows:
     547-1595: Missing.
Note: Lacks the ion channel region.
Isoform M6-kinase 2 (identifier: Q9BX84-6)

The sequence of this isoform differs from the canonical sequence as follows:
     500-1666: Missing.
Note: Lacks the ion channel region.
Isoform M6-kinase 3 (identifier: Q9BX84-7)

The sequence of this isoform differs from the canonical sequence as follows:
     281-281: R → P
     282-1734: Missing.
Note: Lacks the ion channel region.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 20222022Transient receptor potential cation channel subfamily M member 6
PRO_0000215329

Regions

Topological domain1 – 741741Cytoplasmic Potential
Transmembrane742 – 76221Helical; Potential
Topological domain763 – 84179Extracellular Potential
Transmembrane842 – 86221Helical; Potential
Topological domain863 – 90543Cytoplasmic Potential
Transmembrane906 – 92621Helical; Potential
Topological domain927 – 93913Extracellular Potential
Transmembrane940 – 96021Helical; Potential
Topological domain961 – 97212Cytoplasmic Potential
Transmembrane973 – 99321Helical; Potential
Topological domain994 – 101219Extracellular Potential
Intramembrane1013 – 103321Pore-forming; Potential
Topological domain1034 – 104714Extracellular Potential
Transmembrane1048 – 106821Helical; Potential
Topological domain1069 – 2022954Cytoplasmic Potential
Domain1750 – 1980231Alpha-type protein kinase
Nucleotide binding1950 – 19567ATP By similarity

Sites

Active site19231Proton acceptor By similarity
Metal binding19091Zinc By similarity
Metal binding19661Zinc By similarity
Metal binding19681Zinc By similarity
Metal binding19721Zinc By similarity
Binding site17801ATP By similarity
Binding site18041ATP By similarity
Binding site18761ATP By similarity
Binding site19251ATP By similarity
Binding site19331ATP By similarity

Amino acid modifications

Modified residue18511Phosphothreonine; by autocatalysis Ref.5

Natural variations

Alternative sequence1 – 1111MKEQPVLERLQ → MIILSK in isoform TRPM6b.
VSP_012069
Alternative sequence1 – 1111MKEQPVLERLQ → MTAPVT in isoform TRPM6c.
VSP_012070
Alternative sequence2811R → P in isoform M6-kinase 3.
VSP_012071
Alternative sequence282 – 17341453Missing in isoform M6-kinase 3.
VSP_012072
Alternative sequence500 – 16661167Missing in isoform M6-kinase 2.
VSP_012073
Alternative sequence547 – 15951049Missing in isoform M6-kinase 1.
VSP_012074
Alternative sequence1926 – 194318GVGEN…PEVKQ → ALWFWDSMLKARLGGWRM in isoform TRPM6t.
VSP_012075
Alternative sequence1944 – 202279Missing in isoform TRPM6t.
VSP_012076
Natural variant751G → V in a lung adenocarcinoma sample; somatic mutation. Ref.6
VAR_042387
Natural variant1411S → L in HOMG1; impairs heterodimer formation resulting in intracellular retention. Ref.2 Ref.3
VAR_019963
Natural variant3381M → I. Ref.6
Corresponds to variant rs56155062 [ dbSNP | Ensembl ].
VAR_042388
Natural variant9481F → L.
Corresponds to variant rs13290391 [ dbSNP | Ensembl ].
VAR_052380
Natural variant10071W → C in a lung large cell carcinoma sample; somatic mutation. Ref.6
VAR_042389
Natural variant10711N → D.
Corresponds to variant rs2274922 [ dbSNP | Ensembl ].
VAR_019964
Natural variant12431H → R. Ref.6
Corresponds to variant rs55694430 [ dbSNP | Ensembl ].
VAR_042390
Natural variant12741Q → R. Ref.6
Corresponds to variant rs34608911 [ dbSNP | Ensembl ].
VAR_042391
Natural variant13931V → I. Ref.6
Corresponds to variant rs3750425 [ dbSNP | Ensembl ].
VAR_019965
Natural variant15841K → E. Ref.6
Corresponds to variant rs2274924 [ dbSNP | Ensembl ].
VAR_019966
Natural variant16631Q → R. Ref.6
Corresponds to variant rs55679040 [ dbSNP | Ensembl ].
VAR_042392
Natural variant16731L → S. Ref.6
Corresponds to variant rs56254742 [ dbSNP | Ensembl ].
VAR_042393
Natural variant17241T → I. Ref.6
Corresponds to variant rs56290308 [ dbSNP | Ensembl ].
VAR_042394

Experimental info

Mutagenesis18041K → R: Abolishes kinase activity but does not affect expression levels or binding to GNB2L1. Ref.5
Mutagenesis18511T → A: Significantly decreases autophosphorylation. Does not alter binding to GNB2L1 but prevents inhibition by GNB2L1. Ref.5
Mutagenesis18511T → D: Significantly decreases autophosphorylation. Does not alter binding to GNB2L1 or inhibition by GNB2L1. Ref.5

Sequences

Sequence LengthMass (Da)Tools
Isoform TRPM6a [UniParc].

Last modified June 1, 2002. Version 2.
Checksum: 59346B3BE3300466

FASTA2,022231,708
        10         20         30         40         50         60 
MKEQPVLERL QSQKSWIKGV FDKRECSTII PSSKNPHRCT PVCQVCQNLI RCYCGRLIGD 

        70         80         90        100        110        120 
HAGIDYSWTI SAAKGKESEQ WSVEKHTTKS PTDTFGTINF QDGEHTHHAK YIRTSYDTKL 

       130        140        150        160        170        180 
DHLLHLMLKE WKMELPKLVI SVHGGIQNFT MPSKFKEIFS QGLVKAAETT GAWIITEGIN 

       190        200        210        220        230        240 
TGVSKHVGDA LKSHSSHSLR KIWTVGIPPW GVIENQRDLI GKDVVCLYQT LDNPLSKLTT 

       250        260        270        280        290        300 
LNSMHSHFIL SDDGTVGKYG NEMKLRRNLE KYLSLQKIHC RSRQGVPVVG LVVEGGPNVI 

       310        320        330        340        350        360 
LSVWETVKDK DPVVVCEGTG RAADLLAFTH KHLADEGMLR PQVKEEIICM IQNTFNFSLK 

       370        380        390        400        410        420 
QSKHLFQILM ECMVHRDCIT IFDADSEEQQ DLDLAILTAL LKGTNLSASE QLNLAMAWDR 

       430        440        450        460        470        480 
VDIAKKHILI YEQHWKPDAL EQAMSDALVM DRVDFVKLLI EYGVNLHRFL TIPRLEELYN 

       490        500        510        520        530        540 
TKQGPTNTLL HHLVQDVKQH TLLSGYRITL IDIGLVVEYL IGRAYRSNYT RKHFRALYNN 

       550        560        570        580        590        600 
LYRKYKHQRH SSGNRNESAE STLHSQFIRT AQPYKFKEKS IVLHKSRKKS KEQNVSDDPE 

       610        620        630        640        650        660 
STGFLYPYND LLVWAVLMKR QKMAMFFWQH GEEATVKAVI ACILYRAMAH EAKESHMVDD 

       670        680        690        700        710        720 
ASEELKNYSK QFGQLALDLL EKAFKQNERM AMTLLTYELR NWSNSTCLKL AVSGGLRPFV 

       730        740        750        760        770        780 
SHTCTQMLLT DMWMGRLKMR KNSWLKIIIS IILPPTILTL EFKSKAEMSH VPQSQDFQFM 

       790        800        810        820        830        840 
WYYSDQNASS SKESASVKEY DLERGHDEKL DENQHFGLES GHQHLPWTRK VYEFYSAPIV 

       850        860        870        880        890        900 
KFWFYTMAYL AFLMLFTYTV LVEMQPQPSV QEWLVSIYIF TNAIEVVREI CISEPGKFTQ 

       910        920        930        940        950        960 
KVKVWISEYW NLTETVAIGL FSAGFVLRWG DPPFHTAGRL IYCIDIIFWF SRLLDFFAVN 

       970        980        990       1000       1010       1020 
QHAGPYVTMI AKMTANMFYI VIIMAIVLLS FGVARKAILS PKEPPSWSLA RDIVFEPYWM 

      1030       1040       1050       1060       1070       1080 
IYGEVYAGEI DVCSSQPSCP PGSFLTPFLQ AVYLFVQYII MVNLLIAFFN NVYLDMESIS 

      1090       1100       1110       1120       1130       1140 
NNLWKYNRYR YIMTYHEKPW LPPPLILLSH VGLLLRRLCC HRAPHDQEEG DVGLKLYLSK 

      1150       1160       1170       1180       1190       1200 
EDLKKLHDFE EQCVEKYFHE KMEDVNCSCE ERIRVTSERV TEMYFQLKEM NEKVSFIKDS 

      1210       1220       1230       1240       1250       1260 
LLSLDSQVGH LQDLSALTVD TLKVLSAVDT LQEDEALLAK RKHSTCKKLP HSWSNVICAE 

      1270       1280       1290       1300       1310       1320 
VLGSMEIAGE KKYQYYSMPS SLLRSLAGGR HPPRVQRGAL LEITNSKREA TNVRNDQERQ 

      1330       1340       1350       1360       1370       1380 
ETQSSIVVSG VSPNRQAHSK YGQFLLVPSN LKRVPFSAET VLPLSRPSVP DVLATEQDIQ 

      1390       1400       1410       1420       1430       1440 
TEVLVHLTGQ TPVVSDWASV DEPKEKHEPI AHLLDGQDKA EQVLPTLSCT PEPMTMSSPL 

      1450       1460       1470       1480       1490       1500 
SQAKIMQTGG GYVNWAFSEG DETGVFSIKK KWQTCLPSTC DSDSSRSEQH QKQAQDSSLS 

      1510       1520       1530       1540       1550       1560 
DNSTRSAQSS ECSEVGPWLQ PNTSFWINPL RRYRPFARSH SFRFHKEEKL MKICKIKNLS 

      1570       1580       1590       1600       1610       1620 
GSSEIGQGAW VKAKMLTKDR RLSKKKKNTQ GLQVPIITVN ACSQSDQLNP EPGENSISEE 

      1630       1640       1650       1660       1670       1680 
EYSKNWFTVS KFSHTGVEPY IHQKMKTKEI GQCAIQISDY LKQSQEDLSK NSLWNSRSTN 

      1690       1700       1710       1720       1730       1740 
LNRNSLLKSS IGVDKISASL KSPQEPHHHY SAIERNNLMR LSQTIPFTPV QLFAGEEITV 

      1750       1760       1770       1780       1790       1800 
YRLEESSPLN LDKSMSSWSQ RGRAAMIQVL SREEMDGGLR KAMRVVSTWS EDDILKPGQV 

      1810       1820       1830       1840       1850       1860 
FIVKSFLPEV VRTWHKIFQE STVLHLCLRE IQQQRAAQKL IYTFNQVKPQ TIPYTPRFLE 

      1870       1880       1890       1900       1910       1920 
VFLIYCHSAN QWLTIEKYMT GEFRKYNNNN GDEITPTNTL EELMLAFSHW TYEYTRGELL 

      1930       1940       1950       1960       1970       1980 
VLDLQGVGEN LTDPSVIKPE VKQSRGMVFG PANLGEDAIR NFIAKHHCNS CCRKLKLPDL 

      1990       2000       2010       2020 
KRNDYSPERI NSTFGLEIKI ESAEEPPARE TGRNSPEDDM QL 

« Hide

Isoform TRPM6b [UniParc].

Checksum: C96D328F3E9B2A9E
Show »

FASTA2,017231,041
Isoform TRPM6c [UniParc].

Checksum: 7F49198CADF3F64D
Show »

FASTA2,017230,956
Isoform TRPM6t [UniParc].

Checksum: 15F59730C0F345EC
Show »

FASTA1,943223,124
Isoform M6-kinase 1 [UniParc].

Checksum: 4B6503C01BF3F3B6
Show »

FASTA973111,301
Isoform M6-kinase 2 [UniParc].

Checksum: 924C00E589E6FED0
Show »

FASTA85597,520
Isoform M6-kinase 3 [UniParc].

Checksum: 7BF7F1E5163459EF
Show »

FASTA56965,083

References

« Hide 'large scale' references
[1]"Novel type of signaling molecules: protein kinases covalently linked to ion channels."
Riazanova L.V., Pavur K.S., Petrov A.N., Dorovkov M.V., Riazanov A.G.
Mol. Biol. (Mosk.) 35:321-332(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM TRPM6A), CHARACTERIZATION.
Tissue: Kidney.
[2]"Hypomagnesemia with secondary hypocalcemia is caused by mutations in TRPM6, a new member of the TRPM gene family."
Schlingmann K.P., Weber S., Peters M., Niemann Nejsum L.N., Vitzthum H., Klingel K., Kratz M., Haddad E., Ristoff E., Dinour D., Syrrou M., Nielsen S., Sassen M.C., Waldegger S., Seyberth H.W., Konrad M.
Nat. Genet. 31:166-170(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM TRPM6A), VARIANT HOMG1 LEU-141.
Tissue: Kidney and Small intestine.
[3]"Disruption of TRPM6/TRPM7 complex formation by a mutation in the TRPM6 gene causes hypomagnesemia with secondary hypocalcemia."
Chubanov V., Waldegger S., Mederos y Schnitzler M., Vitzthum H., Sassen M.C., Seyberth H.W., Konrad M., Gudermann T.
Proc. Natl. Acad. Sci. U.S.A. 101:2894-2899(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS TRPM6A; TRPM6B; TRPM6C; TRPM6T; M6-KINASE 1; M6-KINASE 2 AND M6-KINASE 3), CHARACTERIZATION OF VARIANT HOMG1 LEU-141, INTERACTION WITH TRPM7.
Tissue: Lung cancer.
[4]"DNA sequence and analysis of human chromosome 9."
Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L. expand/collapse author list , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"RACK1 inhibits TRPM6 activity via phosphorylation of the fused alpha-kinase domain."
Cao G., Thebault S., van der Wijst J., van der Kemp A., Lasonder E., Bindels R.J., Hoenderop J.G.
Curr. Biol. 18:168-176(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH GNB2L1, PHOSPHORYLATION AT THR-1851, MUTAGENESIS OF LYS-1804 AND THR-1851.
[6]"Patterns of somatic mutation in human cancer genomes."
Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G. expand/collapse author list , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R.
Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANTS [LARGE SCALE ANALYSIS] VAL-75; ILE-338; CYS-1007; ARG-1243; ARG-1274; ILE-1393; GLU-1584; ARG-1663; SER-1673 AND ILE-1724.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF350881 mRNA. Translation: AAK31202.2.
AF448232 mRNA. Translation: AAM21562.1.
AY333282 mRNA. Translation: AAR03487.1.
AY333283 mRNA. Translation: AAR03488.1.
AY333284 mRNA. Translation: AAR03489.1.
AY333285 mRNA. Translation: AAR03490.1.
AY333286 mRNA. Translation: AAR03491.1.
AY333287 mRNA. Translation: AAR03492.1.
AY333288 mRNA. Translation: AAR03493.1.
AL354795 Genomic DNA. Translation: CAH70894.1.
RefSeqNP_001170781.1. NM_001177310.1.
NP_001170782.1. NM_001177311.1.
NP_060132.3. NM_017662.4.
UniGeneHs.272225.

3D structure databases

ProteinModelPortalQ9BX84.
SMRQ9BX84. Positions 1174-1223, 1707-1986.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ9BX84. 3 interactions.
MINTMINT-6699468.
STRING9606.ENSP00000354006.

Chemistry

BindingDBQ9BX84.
ChEMBLCHEMBL1628470.
GuidetoPHARMACOLOGY498.

Protein family/group databases

TCDB1.A.4.5.8. the transient receptor potential ca(2+) channel (trp-cc) family.

PTM databases

PhosphoSiteQ9BX84.

Polymorphism databases

DMDM56404951.

Proteomic databases

PaxDbQ9BX84.
PRIDEQ9BX84.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000360774; ENSP00000354006; ENSG00000119121. [Q9BX84-1]
ENST00000361255; ENSP00000354962; ENSG00000119121. [Q9BX84-3]
ENST00000449912; ENSP00000396672; ENSG00000119121. [Q9BX84-2]
GeneID140803.
KEGGhsa:140803.
UCSCuc004ajk.1. human. [Q9BX84-3]
uc004ajl.1. human. [Q9BX84-1]
uc010mpc.1. human. [Q9BX84-5]
uc010mpd.1. human. [Q9BX84-6]
uc010mpe.1. human. [Q9BX84-7]
uc022bib.1. human. [Q9BX84-2]

Organism-specific databases

CTD140803.
GeneCardsGC09M077337.
H-InvDBHIX0008102.
HGNCHGNC:17995. TRPM6.
HPAHPA007037.
MIM602014. phenotype.
607009. gene.
neXtProtNX_Q9BX84.
Orphanet30924. Autosomal recessive primary hypomagnesemia with normocalcuria and hypocalcemia.
PharmGKBPA38479.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG253824.
HOGENOMHOG000230920.
HOVERGENHBG055663.
KOK04981.
OrthoDBEOG7NPFSC.
PhylomeDBQ9BX84.
TreeFamTF314204.

Enzyme and pathway databases

ReactomeREACT_15518. Transmembrane transport of small molecules.

Gene expression databases

ArrayExpressQ9BX84.
BgeeQ9BX84.
CleanExHS_TRPM6.
GenevestigatorQ9BX84.

Family and domain databases

InterProIPR011009. Kinase-like_dom.
IPR004166. MHCK_EF2_kinase.
[Graphical view]
PfamPF02816. Alpha_kinase. 1 hit.
[Graphical view]
SMARTSM00811. Alpha_kinase. 1 hit.
[Graphical view]
SUPFAMSSF56112. SSF56112. 1 hit.
PROSITEPS51158. ALPHA_KINASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiTRPM6.
GenomeRNAi140803.
NextBio84406.
PROQ9BX84.
SOURCESearch...

Entry information

Entry nameTRPM6_HUMAN
AccessionPrimary (citable) accession number: Q9BX84
Secondary accession number(s): Q6VPR8 expand/collapse secondary AC list , Q6VPR9, Q6VPS0, Q6VPS1, Q6VPS2
Entry history
Integrated into UniProtKB/Swiss-Prot: December 7, 2004
Last sequence update: June 1, 2002
Last modified: April 16, 2014
This is version 113 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human and mouse protein kinases

Human and mouse protein kinases: classification and index

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 9

Human chromosome 9: entries, gene names and cross-references to MIM