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Q9BX82 (ZN471_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 121. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Zinc finger protein 471
Alternative name(s):
EZFIT-related protein 1
Gene names
Name:ZNF471
Synonyms:ERP1, KIAA1396
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length626 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May be involved in transcriptional regulation.

Subcellular location

Nucleus Potential.

Sequence similarities

Belongs to the krueppel C2H2-type zinc-finger protein family.

Contains 15 C2H2-type zinc fingers.

Contains 1 KRAB domain.

Sequence caution

The sequence AAC32422.1 differs from that shown. Reason: Erroneous gene model prediction.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 626626Zinc finger protein 471
PRO_0000047603

Regions

Domain14 – 8572KRAB
Zinc finger206 – 22823C2H2-type 1
Zinc finger234 – 25623C2H2-type 2
Zinc finger262 – 28423C2H2-type 3
Zinc finger290 – 31223C2H2-type 4
Zinc finger318 – 34023C2H2-type 5
Zinc finger346 – 36924C2H2-type 6
Zinc finger375 – 39723C2H2-type 7
Zinc finger403 – 42523C2H2-type 8
Zinc finger431 – 45323C2H2-type 9
Zinc finger459 – 48123C2H2-type 10
Zinc finger487 – 50923C2H2-type 11
Zinc finger515 – 53723C2H2-type 12
Zinc finger543 – 56523C2H2-type 13
Zinc finger571 – 59323C2H2-type 14
Zinc finger599 – 62123C2H2-type 15

Natural variations

Natural variant1921M → I. Ref.6
Corresponds to variant rs11667052 [ dbSNP | Ensembl ].
VAR_052836
Natural variant3091Q → R.
Corresponds to variant rs45487092 [ dbSNP | Ensembl ].
VAR_061951
Natural variant3611F → C in a colorectal cancer sample; somatic mutation. Ref.7
VAR_035583
Natural variant4061G → D. Ref.2 Ref.5 Ref.6
Corresponds to variant rs3752176 [ dbSNP | Ensembl ].
VAR_052837
Natural variant5561S → C. Ref.6
Corresponds to variant rs16987303 [ dbSNP | Ensembl ].
VAR_052838

Experimental info

Sequence conflict611Y → C in CAD38551. Ref.3
Sequence conflict4071V → A in CAD38551. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Q9BX82 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: 7F47ACFB04CE99AA

FASTA62673,009
        10         20         30         40         50         60 
MNVEVVKVMP QDLVTFKDVA IDFSQEEWQW MNPAQKRLYR SMMLENYQSL VSLGLCISKP 

        70         80         90        100        110        120 
YVISLLEQGR EPWEMTSEMT RSPFSDWESI YVTQELPLKQ FMYDDACMEG ITSYGLECST 

       130        140        150        160        170        180 
FEENWKWEDL FEKQMGSHEM FSKKEIITHK ETITKETEFK YTKFGKCIHL ENIEESIYNH 

       190        200        210        220        230        240 
TSDKKSFSKN SMVIKHKKVY VGKKLFKCNE CDKTFTHSSS LTVHFRIHTG EKPYACEECG 

       250        260        270        280        290        300 
KAFKQRQHLA QHHRTHTGEK LFECKECRKA FKQSEHLIQH QRIHTGEKPY KCKECRKAFR 

       310        320        330        340        350        360 
QPAHLAQHQR IHTGEKPYEC KECGKAFSDG SSFARHQRCH TGKRPYECIE CGKAFRYNTS 

       370        380        390        400        410        420 
FIRHWRSYHT GEKPFNCIDC GKAFSVHIGL ILHRRIHTGE KPYKCGVCGK TFSSGSSRTV 

       430        440        450        460        470        480 
HQRIHTGEKP YECDICGKDF SHHASLTQHQ RVHSGEKPYE CKECGKAFRQ NVHLVSHLRI 

       490        500        510        520        530        540 
HTGEKPYECK ECGKAFRISS QLATHQRIHT GEKPYECIEC GNAFKQRSHL AQHQKTHTGE 

       550        560        570        580        590        600 
KPYECNECGK AFSQTSNLTQ HQRIHTGEKP YKCTECGKAF SDSSSCAQHQ RLHTGQRPYQ 

       610        620 
CFECGKAFRR KLSLICHQRS HTGEEP 

« Hide

References

« Hide 'large scale' references
[1]"EZFIT-related protein 1."
Mataki C., Murakami T., Umetani M., Wada Y., Hamakubo T., Kodama T.
Submitted (FEB-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Pancreas.
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ASP-406.
Tissue: Brain.
[3]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Skeletal muscle.
[4]"The DNA sequence and biology of human chromosome 19."
Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. expand/collapse author list , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ASP-406.
[6]"Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro."
Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O.
DNA Res. 7:65-73(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 76-626, VARIANTS ILE-192; ASP-406 AND CYS-556.
Tissue: Brain.
[7]"The consensus coding sequences of human breast and colorectal cancers."
Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. expand/collapse author list , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E.
Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT [LARGE SCALE ANALYSIS] CYS-361.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF352026 mRNA. Translation: AAK30252.1.
AK291416 mRNA. Translation: BAF84105.1.
AL831845 mRNA. Translation: CAD38551.1.
AC004696 Genomic DNA. No translation available.
AC005498 Genomic DNA. Translation: AAC32422.1. Sequence problems.
BC125221 mRNA. Translation: AAI25222.1.
BC125222 mRNA. Translation: AAI25223.1.
AB037817 mRNA. Translation: BAA92634.1.
CCDSCCDS12945.1.
RefSeqNP_065864.2. NM_020813.2.
UniGeneHs.710590.

3D structure databases

ProteinModelPortalQ9BX82.
SMRQ9BX82. Positions 14-54, 180-626.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid121626. 3 interactions.
IntActQ9BX82. 1 interaction.
MINTMINT-2816434.
STRING9606.ENSP00000309161.

PTM databases

PhosphoSiteQ9BX82.

Polymorphism databases

DMDM37999856.

Proteomic databases

PaxDbQ9BX82.
PRIDEQ9BX82.

Protocols and materials databases

DNASU57573.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000308031; ENSP00000309161; ENSG00000196263.
GeneID57573.
KEGGhsa:57573.
UCSCuc002qnh.3. human.

Organism-specific databases

CTD57573.
GeneCardsGC19P057019.
HGNCHGNC:23226. ZNF471.
neXtProtNX_Q9BX82.
PharmGKBPA134940750.
HUGESearch...
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG5048.
HOGENOMHOG000234617.
HOVERGENHBG018163.
InParanoidQ9BX82.
KOK09228.
OMAPFSDWES.
OrthoDBEOG7KSX7Q.
PhylomeDBQ9BX82.
TreeFamTF341817.

Enzyme and pathway databases

ReactomeREACT_71. Gene Expression.

Gene expression databases

ArrayExpressQ9BX82.
BgeeQ9BX82.
CleanExHS_ZNF471.
GenevestigatorQ9BX82.

Family and domain databases

Gene3D3.30.160.60. 15 hits.
InterProIPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamPF01352. KRAB. 1 hit.
[Graphical view]
SMARTSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 15 hits.
[Graphical view]
SUPFAMSSF109640. SSF109640. 1 hit.
PROSITEPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 15 hits.
PS50157. ZINC_FINGER_C2H2_2. 15 hits.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiZNF471.
GenomeRNAi57573.
NextBio64105.
PROQ9BX82.

Entry information

Entry nameZN471_HUMAN
AccessionPrimary (citable) accession number: Q9BX82
Secondary accession number(s): O75260 expand/collapse secondary AC list , Q08AD6, Q08AD7, Q8N3V1, Q9P2F1
Entry history
Integrated into UniProtKB/Swiss-Prot: October 24, 2003
Last sequence update: June 1, 2001
Last modified: July 9, 2014
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM