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Protein

Zinc finger protein 471

Gene

ZNF471

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri206 – 22823C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri234 – 25623C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri262 – 28423C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri290 – 31223C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri318 – 34023C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri346 – 36924C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri375 – 39723C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri403 – 42523C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri431 – 45323C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri459 – 48123C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri487 – 50923C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri515 – 53723C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri543 – 56523C2H2-type 13PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri571 – 59323C2H2-type 14PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri599 – 62123C2H2-type 15PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW
  3. sequence-specific DNA binding transcription factor activity Source: GO_Central

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: GO_Central
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_12627. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 471
Alternative name(s):
EZFIT-related protein 1
Gene namesi
Name:ZNF471
Synonyms:ERP1, KIAA1396
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:23226. ZNF471.

Subcellular locationi

Nucleus Curated

GO - Cellular componenti

  1. nucleus Source: LIFEdb
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134940750.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 626626Zinc finger protein 471PRO_0000047603Add
BLAST

Proteomic databases

PaxDbiQ9BX82.
PRIDEiQ9BX82.

PTM databases

PhosphoSiteiQ9BX82.

Expressioni

Gene expression databases

BgeeiQ9BX82.
CleanExiHS_ZNF471.
ExpressionAtlasiQ9BX82. baseline and differential.
GenevestigatoriQ9BX82.

Interactioni

Protein-protein interaction databases

BioGridi121626. 10 interactions.
IntActiQ9BX82. 1 interaction.
MINTiMINT-2816434.
STRINGi9606.ENSP00000309161.

Structurei

3D structure databases

ProteinModelPortaliQ9BX82.
SMRiQ9BX82. Positions 14-54, 203-626.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini14 – 8572KRABPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 15 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri206 – 22823C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri234 – 25623C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri262 – 28423C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri290 – 31223C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri318 – 34023C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri346 – 36924C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri375 – 39723C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri403 – 42523C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri431 – 45323C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri459 – 48123C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri487 – 50923C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri515 – 53723C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri543 – 56523C2H2-type 13PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri571 – 59323C2H2-type 14PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri599 – 62123C2H2-type 15PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5048.
GeneTreeiENSGT00780000121890.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ9BX82.
KOiK09228.
OMAiPFSDWES.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ9BX82.
TreeFamiTF341817.

Family and domain databases

Gene3Di3.30.160.60. 15 hits.
InterProiIPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 15 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 15 hits.
PS50157. ZINC_FINGER_C2H2_2. 15 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9BX82-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNVEVVKVMP QDLVTFKDVA IDFSQEEWQW MNPAQKRLYR SMMLENYQSL
60 70 80 90 100
VSLGLCISKP YVISLLEQGR EPWEMTSEMT RSPFSDWESI YVTQELPLKQ
110 120 130 140 150
FMYDDACMEG ITSYGLECST FEENWKWEDL FEKQMGSHEM FSKKEIITHK
160 170 180 190 200
ETITKETEFK YTKFGKCIHL ENIEESIYNH TSDKKSFSKN SMVIKHKKVY
210 220 230 240 250
VGKKLFKCNE CDKTFTHSSS LTVHFRIHTG EKPYACEECG KAFKQRQHLA
260 270 280 290 300
QHHRTHTGEK LFECKECRKA FKQSEHLIQH QRIHTGEKPY KCKECRKAFR
310 320 330 340 350
QPAHLAQHQR IHTGEKPYEC KECGKAFSDG SSFARHQRCH TGKRPYECIE
360 370 380 390 400
CGKAFRYNTS FIRHWRSYHT GEKPFNCIDC GKAFSVHIGL ILHRRIHTGE
410 420 430 440 450
KPYKCGVCGK TFSSGSSRTV HQRIHTGEKP YECDICGKDF SHHASLTQHQ
460 470 480 490 500
RVHSGEKPYE CKECGKAFRQ NVHLVSHLRI HTGEKPYECK ECGKAFRISS
510 520 530 540 550
QLATHQRIHT GEKPYECIEC GNAFKQRSHL AQHQKTHTGE KPYECNECGK
560 570 580 590 600
AFSQTSNLTQ HQRIHTGEKP YKCTECGKAF SDSSSCAQHQ RLHTGQRPYQ
610 620
CFECGKAFRR KLSLICHQRS HTGEEP
Length:626
Mass (Da):73,009
Last modified:June 1, 2001 - v1
Checksum:i7F47ACFB04CE99AA
GO
Isoform 2 (identifier: Q9BX82-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     86-247: DWESIYVTQE...ECGKAFKQRQ → EFILVKNHMH...LIVGKPSVFT
     248-626: Missing.

Note: No experimental confirmation available.

Show »
Length:247
Mass (Da):28,176
Checksum:i29DE370951019E57
GO

Sequence cautioni

The sequence AAC32422.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti61 – 611Y → C in CAD38551. (PubMed:17974005)Curated
Sequence conflicti407 – 4071V → A in CAD38551. (PubMed:17974005)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti192 – 1921M → I.1 Publication
Corresponds to variant rs11667052 [ dbSNP | Ensembl ].
VAR_052836
Natural varianti309 – 3091Q → R.
Corresponds to variant rs45487092 [ dbSNP | Ensembl ].
VAR_061951
Natural varianti361 – 3611F → C in a colorectal cancer sample; somatic mutation. 1 Publication
VAR_035583
Natural varianti406 – 4061G → D.3 Publications
Corresponds to variant rs3752176 [ dbSNP | Ensembl ].
VAR_052837
Natural varianti556 – 5561S → C.1 Publication
Corresponds to variant rs16987303 [ dbSNP | Ensembl ].
VAR_052838

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei86 – 247162DWESI…FKQRQ → EFILVKNHMHVRNVEKPSSK GNTLLNITEHILERNSLNVK NVGKPSNKVNTLFSIKEFIL EKNHINVRNAEKPSDSLHTL LSIREFILERNPMNVKNVAK PSVMARLLLDIRDVTLAKDP MNVLSVGRLLGITHLLFVTG GVIILERSLLIALIVGKPSV FT in isoform 2. 1 PublicationVSP_055955Add
BLAST
Alternative sequencei248 – 626379Missing in isoform 2. 1 PublicationVSP_055956Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF352026 mRNA. Translation: AAK30252.1.
AK291416 mRNA. Translation: BAF84105.1.
AK293908 mRNA. Translation: BAG57293.1.
AL831845 mRNA. Translation: CAD38551.1.
AC004696 Genomic DNA. No translation available.
AC005498 Genomic DNA. Translation: AAC32422.1. Sequence problems.
BC125221 mRNA. Translation: AAI25222.1.
BC125222 mRNA. Translation: AAI25223.1.
AB037817 mRNA. Translation: BAA92634.1.
CCDSiCCDS12945.1. [Q9BX82-1]
RefSeqiNP_065864.2. NM_020813.2. [Q9BX82-1]
UniGeneiHs.710590.

Genome annotation databases

EnsembliENST00000308031; ENSP00000309161; ENSG00000196263. [Q9BX82-1]
ENST00000591537; ENSP00000466224; ENSG00000196263. [Q9BX82-2]
GeneIDi57573.
KEGGihsa:57573.
UCSCiuc002qnh.3. human. [Q9BX82-1]

Polymorphism databases

DMDMi37999856.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF352026 mRNA. Translation: AAK30252.1.
AK291416 mRNA. Translation: BAF84105.1.
AK293908 mRNA. Translation: BAG57293.1.
AL831845 mRNA. Translation: CAD38551.1.
AC004696 Genomic DNA. No translation available.
AC005498 Genomic DNA. Translation: AAC32422.1. Sequence problems.
BC125221 mRNA. Translation: AAI25222.1.
BC125222 mRNA. Translation: AAI25223.1.
AB037817 mRNA. Translation: BAA92634.1.
CCDSiCCDS12945.1. [Q9BX82-1]
RefSeqiNP_065864.2. NM_020813.2. [Q9BX82-1]
UniGeneiHs.710590.

3D structure databases

ProteinModelPortaliQ9BX82.
SMRiQ9BX82. Positions 14-54, 203-626.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121626. 10 interactions.
IntActiQ9BX82. 1 interaction.
MINTiMINT-2816434.
STRINGi9606.ENSP00000309161.

PTM databases

PhosphoSiteiQ9BX82.

Polymorphism databases

DMDMi37999856.

Proteomic databases

PaxDbiQ9BX82.
PRIDEiQ9BX82.

Protocols and materials databases

DNASUi57573.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000308031; ENSP00000309161; ENSG00000196263. [Q9BX82-1]
ENST00000591537; ENSP00000466224; ENSG00000196263. [Q9BX82-2]
GeneIDi57573.
KEGGihsa:57573.
UCSCiuc002qnh.3. human. [Q9BX82-1]

Organism-specific databases

CTDi57573.
GeneCardsiGC19P057019.
HGNCiHGNC:23226. ZNF471.
neXtProtiNX_Q9BX82.
PharmGKBiPA134940750.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG5048.
GeneTreeiENSGT00780000121890.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ9BX82.
KOiK09228.
OMAiPFSDWES.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ9BX82.
TreeFamiTF341817.

Enzyme and pathway databases

ReactomeiREACT_12627. Generic Transcription Pathway.

Miscellaneous databases

GeneWikiiZNF471.
GenomeRNAii57573.
NextBioi35471390.
PROiQ9BX82.

Gene expression databases

BgeeiQ9BX82.
CleanExiHS_ZNF471.
ExpressionAtlasiQ9BX82. baseline and differential.
GenevestigatoriQ9BX82.

Family and domain databases

Gene3Di3.30.160.60. 15 hits.
InterProiIPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 15 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 15 hits.
PS50157. ZINC_FINGER_C2H2_2. 15 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "EZFIT-related protein 1."
    Mataki C., Murakami T., Umetani M., Wada Y., Hamakubo T., Kodama T.
    Submitted (FEB-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Pancreas.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANT ASP-406.
    Tissue: Brain and Cerebellum.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Skeletal muscle.
  4. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ASP-406.
  6. "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O.
    DNA Res. 7:65-73(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 76-626 (ISOFORM 1), VARIANTS ILE-192; ASP-406 AND CYS-556.
    Tissue: Brain.
  7. Cited for: VARIANT [LARGE SCALE ANALYSIS] CYS-361.

Entry informationi

Entry nameiZN471_HUMAN
AccessioniPrimary (citable) accession number: Q9BX82
Secondary accession number(s): B4DF32
, O75260, Q08AD6, Q08AD7, Q8N3V1, Q9P2F1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 24, 2003
Last sequence update: June 1, 2001
Last modified: February 4, 2015
This is version 127 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.