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Q9BX82

- ZN471_HUMAN

UniProt

Q9BX82 - ZN471_HUMAN

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Protein
Zinc finger protein 471
Gene
ZNF471, ERP1, KIAA1396
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri206 – 22823C2H2-type 1
Add
BLAST
Zinc fingeri234 – 25623C2H2-type 2
Add
BLAST
Zinc fingeri262 – 28423C2H2-type 3
Add
BLAST
Zinc fingeri290 – 31223C2H2-type 4
Add
BLAST
Zinc fingeri318 – 34023C2H2-type 5
Add
BLAST
Zinc fingeri346 – 36924C2H2-type 6
Add
BLAST
Zinc fingeri375 – 39723C2H2-type 7
Add
BLAST
Zinc fingeri403 – 42523C2H2-type 8
Add
BLAST
Zinc fingeri431 – 45323C2H2-type 9
Add
BLAST
Zinc fingeri459 – 48123C2H2-type 10
Add
BLAST
Zinc fingeri487 – 50923C2H2-type 11
Add
BLAST
Zinc fingeri515 – 53723C2H2-type 12
Add
BLAST
Zinc fingeri543 – 56523C2H2-type 13
Add
BLAST
Zinc fingeri571 – 59323C2H2-type 14
Add
BLAST
Zinc fingeri599 – 62123C2H2-type 15
Add
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW
  3. sequence-specific DNA binding transcription factor activity Source: RefGenome

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: RefGenome
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_12627. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 471
Alternative name(s):
EZFIT-related protein 1
Gene namesi
Name:ZNF471
Synonyms:ERP1, KIAA1396
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:23226. ZNF471.

Subcellular locationi

Nucleus Reviewed prediction

GO - Cellular componenti

  1. nucleus Source: LIFEdb
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134940750.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 626626Zinc finger protein 471
PRO_0000047603Add
BLAST

Proteomic databases

PaxDbiQ9BX82.
PRIDEiQ9BX82.

PTM databases

PhosphoSiteiQ9BX82.

Expressioni

Gene expression databases

ArrayExpressiQ9BX82.
BgeeiQ9BX82.
CleanExiHS_ZNF471.
GenevestigatoriQ9BX82.

Interactioni

Protein-protein interaction databases

BioGridi121626. 3 interactions.
IntActiQ9BX82. 1 interaction.
MINTiMINT-2816434.
STRINGi9606.ENSP00000309161.

Structurei

3D structure databases

ProteinModelPortaliQ9BX82.
SMRiQ9BX82. Positions 14-54, 180-626.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini14 – 8572KRAB
Add
BLAST

Sequence similaritiesi

Contains 15 C2H2-type zinc fingers.
Contains 1 KRAB domain.

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5048.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ9BX82.
KOiK09228.
OMAiPFSDWES.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ9BX82.
TreeFamiTF341817.

Family and domain databases

Gene3Di3.30.160.60. 15 hits.
InterProiIPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 15 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 15 hits.
PS50157. ZINC_FINGER_C2H2_2. 15 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9BX82-1 [UniParc]FASTAAdd to Basket

« Hide

MNVEVVKVMP QDLVTFKDVA IDFSQEEWQW MNPAQKRLYR SMMLENYQSL    50
VSLGLCISKP YVISLLEQGR EPWEMTSEMT RSPFSDWESI YVTQELPLKQ 100
FMYDDACMEG ITSYGLECST FEENWKWEDL FEKQMGSHEM FSKKEIITHK 150
ETITKETEFK YTKFGKCIHL ENIEESIYNH TSDKKSFSKN SMVIKHKKVY 200
VGKKLFKCNE CDKTFTHSSS LTVHFRIHTG EKPYACEECG KAFKQRQHLA 250
QHHRTHTGEK LFECKECRKA FKQSEHLIQH QRIHTGEKPY KCKECRKAFR 300
QPAHLAQHQR IHTGEKPYEC KECGKAFSDG SSFARHQRCH TGKRPYECIE 350
CGKAFRYNTS FIRHWRSYHT GEKPFNCIDC GKAFSVHIGL ILHRRIHTGE 400
KPYKCGVCGK TFSSGSSRTV HQRIHTGEKP YECDICGKDF SHHASLTQHQ 450
RVHSGEKPYE CKECGKAFRQ NVHLVSHLRI HTGEKPYECK ECGKAFRISS 500
QLATHQRIHT GEKPYECIEC GNAFKQRSHL AQHQKTHTGE KPYECNECGK 550
AFSQTSNLTQ HQRIHTGEKP YKCTECGKAF SDSSSCAQHQ RLHTGQRPYQ 600
CFECGKAFRR KLSLICHQRS HTGEEP 626
Length:626
Mass (Da):73,009
Last modified:June 1, 2001 - v1
Checksum:i7F47ACFB04CE99AA
GO

Sequence cautioni

The sequence AAC32422.1 differs from that shown. Reason: Erroneous gene model prediction.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti192 – 1921M → I.1 Publication
Corresponds to variant rs11667052 [ dbSNP | Ensembl ].
VAR_052836
Natural varianti309 – 3091Q → R.
Corresponds to variant rs45487092 [ dbSNP | Ensembl ].
VAR_061951
Natural varianti361 – 3611F → C in a colorectal cancer sample; somatic mutation. 1 Publication
VAR_035583
Natural varianti406 – 4061G → D.3 Publications
Corresponds to variant rs3752176 [ dbSNP | Ensembl ].
VAR_052837
Natural varianti556 – 5561S → C.1 Publication
Corresponds to variant rs16987303 [ dbSNP | Ensembl ].
VAR_052838

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti61 – 611Y → C in CAD38551. 1 Publication
Sequence conflicti407 – 4071V → A in CAD38551. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF352026 mRNA. Translation: AAK30252.1.
AK291416 mRNA. Translation: BAF84105.1.
AL831845 mRNA. Translation: CAD38551.1.
AC004696 Genomic DNA. No translation available.
AC005498 Genomic DNA. Translation: AAC32422.1. Sequence problems.
BC125221 mRNA. Translation: AAI25222.1.
BC125222 mRNA. Translation: AAI25223.1.
AB037817 mRNA. Translation: BAA92634.1.
CCDSiCCDS12945.1.
RefSeqiNP_065864.2. NM_020813.2.
UniGeneiHs.710590.

Genome annotation databases

EnsembliENST00000308031; ENSP00000309161; ENSG00000196263.
GeneIDi57573.
KEGGihsa:57573.
UCSCiuc002qnh.3. human.

Polymorphism databases

DMDMi37999856.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF352026 mRNA. Translation: AAK30252.1 .
AK291416 mRNA. Translation: BAF84105.1 .
AL831845 mRNA. Translation: CAD38551.1 .
AC004696 Genomic DNA. No translation available.
AC005498 Genomic DNA. Translation: AAC32422.1 . Sequence problems.
BC125221 mRNA. Translation: AAI25222.1 .
BC125222 mRNA. Translation: AAI25223.1 .
AB037817 mRNA. Translation: BAA92634.1 .
CCDSi CCDS12945.1.
RefSeqi NP_065864.2. NM_020813.2.
UniGenei Hs.710590.

3D structure databases

ProteinModelPortali Q9BX82.
SMRi Q9BX82. Positions 14-54, 180-626.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 121626. 3 interactions.
IntActi Q9BX82. 1 interaction.
MINTi MINT-2816434.
STRINGi 9606.ENSP00000309161.

PTM databases

PhosphoSitei Q9BX82.

Polymorphism databases

DMDMi 37999856.

Proteomic databases

PaxDbi Q9BX82.
PRIDEi Q9BX82.

Protocols and materials databases

DNASUi 57573.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000308031 ; ENSP00000309161 ; ENSG00000196263 .
GeneIDi 57573.
KEGGi hsa:57573.
UCSCi uc002qnh.3. human.

Organism-specific databases

CTDi 57573.
GeneCardsi GC19P057019.
HGNCi HGNC:23226. ZNF471.
neXtProti NX_Q9BX82.
PharmGKBi PA134940750.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5048.
HOGENOMi HOG000234617.
HOVERGENi HBG018163.
InParanoidi Q9BX82.
KOi K09228.
OMAi PFSDWES.
OrthoDBi EOG7KSX7Q.
PhylomeDBi Q9BX82.
TreeFami TF341817.

Enzyme and pathway databases

Reactomei REACT_12627. Generic Transcription Pathway.

Miscellaneous databases

GeneWikii ZNF471.
GenomeRNAii 57573.
NextBioi 64105.
PROi Q9BX82.

Gene expression databases

ArrayExpressi Q9BX82.
Bgeei Q9BX82.
CleanExi HS_ZNF471.
Genevestigatori Q9BX82.

Family and domain databases

Gene3Di 3.30.160.60. 15 hits.
InterProi IPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view ]
Pfami PF01352. KRAB. 1 hit.
[Graphical view ]
SMARTi SM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 15 hits.
[Graphical view ]
SUPFAMi SSF109640. SSF109640. 1 hit.
PROSITEi PS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 15 hits.
PS50157. ZINC_FINGER_C2H2_2. 15 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "EZFIT-related protein 1."
    Mataki C., Murakami T., Umetani M., Wada Y., Hamakubo T., Kodama T.
    Submitted (FEB-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Pancreas.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ASP-406.
    Tissue: Brain.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Skeletal muscle.
  4. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ASP-406.
  6. "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O.
    DNA Res. 7:65-73(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 76-626, VARIANTS ILE-192; ASP-406 AND CYS-556.
    Tissue: Brain.
  7. Cited for: VARIANT [LARGE SCALE ANALYSIS] CYS-361.

Entry informationi

Entry nameiZN471_HUMAN
AccessioniPrimary (citable) accession number: Q9BX82
Secondary accession number(s): O75260
, Q08AD6, Q08AD7, Q8N3V1, Q9P2F1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 24, 2003
Last sequence update: June 1, 2001
Last modified: September 3, 2014
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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