##gff-version 3 Q9BX79 UniProtKB Chain 1 667 . . . ID=PRO_0000311228;Note=Receptor for retinol uptake STRA6 Q9BX79 UniProtKB Topological domain 1 50 . . . Note=Extracellular;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:F1RAX4 Q9BX79 UniProtKB Transmembrane 51 71 . . . Note=Helical;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:F1RAX4 Q9BX79 UniProtKB Topological domain 72 100 . . . Note=Cytoplasmic;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:F1RAX4 Q9BX79 UniProtKB Transmembrane 101 121 . . . Note=Helical;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:F1RAX4 Q9BX79 UniProtKB Topological domain 122 144 . . . Note=Extracellular;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:F1RAX4 Q9BX79 UniProtKB Transmembrane 145 165 . . . Note=Helical;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:F1RAX4 Q9BX79 UniProtKB Topological domain 166 168 . . . Note=Cytoplasmic;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:F1RAX4 Q9BX79 UniProtKB Transmembrane 169 189 . . . Note=Helical;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:F1RAX4 Q9BX79 UniProtKB Topological domain 190 205 . . . Note=Extracellular;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:F1RAX4 Q9BX79 UniProtKB Transmembrane 206 226 . . . Note=Helical;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:F1RAX4 Q9BX79 UniProtKB Topological domain 227 295 . . . Note=Cytoplasmic;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:F1RAX4 Q9BX79 UniProtKB Transmembrane 296 316 . . . Note=Helical;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:F1RAX4 Q9BX79 UniProtKB Topological domain 317 367 . . . Note=Extracellular;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:F1RAX4 Q9BX79 UniProtKB Transmembrane 368 388 . . . Note=Helical;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:F1RAX4 Q9BX79 UniProtKB Topological domain 389 422 . . . Note=Cytoplasmic;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:F1RAX4 Q9BX79 UniProtKB Transmembrane 423 443 . . . Note=Helical;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:F1RAX4 Q9BX79 UniProtKB Topological domain 444 473 . . . Note=Extracellular;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:F1RAX4 Q9BX79 UniProtKB Transmembrane 474 494 . . . Note=Helical;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:F1RAX4 Q9BX79 UniProtKB Topological domain 495 509 . . . Note=Cytoplasmic;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:F1RAX4 Q9BX79 UniProtKB Intramembrane 510 547 . . . Note=Helical;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:F1RAX4 Q9BX79 UniProtKB Topological domain 548 667 . . . Note=Cytoplasmic;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:F1RAX4 Q9BX79 UniProtKB Region 1 20 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q9BX79 UniProtKB Region 235 293 . . . Note=Interaction with RBP1;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22665496;Dbxref=PMID:22665496 Q9BX79 UniProtKB Compositional bias 1 17 . . . Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q9BX79 UniProtKB Modified residue 643 643 . . . Note=Phosphotyrosine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21368206;Dbxref=PMID:21368206 Q9BX79 UniProtKB Glycosylation 8 8 . . . Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q9BX79 UniProtKB Alternative sequence 1 1 . . . ID=VSP_029437;Note=In isoform 4. M->MGGKGGGDTRGPVLFPCQLAQALSPRRAFPRELKEKGQRM;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005 Q9BX79 UniProtKB Alternative sequence 1 1 . . . ID=VSP_046776;Note=In isoform 5. M->MQIRLLRAELVVPLWQFIRQWPPGSDGWGQMEEKGQRM;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 Q9BX79 UniProtKB Alternative sequence 1 1 . . . ID=VSP_047497;Note=In isoform 6. M->MDSQGDWAAQEKGQRM;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 Q9BX79 UniProtKB Alternative sequence 89 97 . . . ID=VSP_029438;Note=In isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:11358845,ECO:0000303|PubMed:12975309;Dbxref=PMID:11358845,PMID:12975309 Q9BX79 UniProtKB Alternative sequence 145 667 . . . ID=VSP_029439;Note=In isoform 2. AWKILGLFYYAALYYPLAACATAGHTAAHLLGSTLSWAHLGVQVWQRAECPQVPKIYKYYSLLASLPLLLGLGFLSLWYPVQLVRSFSRRTGAGSKGLQSSYSEEYLRNLLCRKKLGSSYHTSKHGFLSWARVCLRHCIYTPQPGFHLPLKLVLSATLTGTAIYQVALLLLVGVVPTIQKVRAGVTTDVSYLLAGFGIVLSEDKQEVVELVKHHLWALEVCYISALVLSCLLTFLVLMRSLVTHRTNLRALHRGAALDLSPLHRSPHPSRQAIFCWMSFSAYQTAFICLGLLVQQIIFFLGTTALAFLVLMPVLHGRNLLLFRSLESSWPFWLTLALAVILQNMAAHWVFLETHDGHPQLTNRRVLYAATFLLFPLNVLVGAMVATWRVLLSALYNAIHLGQMDLSLLPPRAATLDPGYYTYRNFLKIEVSQSHPAMTAFCSLLLQAQSLLPRTMAAPQDSLRPGEEDEGMQLLQTKDSMAKGARPGASRGRARWGLAYTLLHNPTLQVFRKTALLGANGAQP->NLPKITELRLVRAWI;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334 Q9BX79 UniProtKB Natural variant 90 90 . . . ID=VAR_037168;Note=In MCOPS9. P->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17273977;Dbxref=dbSNP:rs118203961,PMID:17273977 Q9BX79 UniProtKB Natural variant 217 217 . . . ID=VAR_060203;Note=In anophthalmia/microphthalmia. G->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19112531;Dbxref=dbSNP:rs909629751,PMID:19112531 Q9BX79 UniProtKB Natural variant 293 293 . . . ID=VAR_037169;Note=In MCOPS9. P->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17273977;Dbxref=dbSNP:rs118203958,PMID:17273977 Q9BX79 UniProtKB Natural variant 304 304 . . . ID=VAR_066849;Note=In MCOPS9%3B also found in a family with isolated colobomatous microphthalmia%3B affects STRA6 cell surface expression and retinol uptake%3B requires 2 nucleotide substitutions. G->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21901792;Dbxref=dbSNP:rs151341424,PMID:21901792 Q9BX79 UniProtKB Natural variant 321 321 . . . ID=VAR_037170;Note=In MCOPS9. T->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17273977;Dbxref=dbSNP:rs118203962,PMID:17273977 Q9BX79 UniProtKB Natural variant 339 339 . . . ID=VAR_037171;Note=G->S;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15489334,ECO:0000269|PubMed:15498874;Dbxref=dbSNP:rs17852249,PMID:15489334,PMID:15498874 Q9BX79 UniProtKB Natural variant 438 438 . . . ID=VAR_060204;Note=In anophthalmia/microphthalmia. Q->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19309693;Dbxref=dbSNP:rs869025269,PMID:19309693 Q9BX79 UniProtKB Natural variant 517 517 . . . ID=VAR_037172;Note=L->F;Dbxref=dbSNP:rs11545567 Q9BX79 UniProtKB Natural variant 527 527 . . . ID=VAR_037173;Note=M->I;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11358845,ECO:0000269|PubMed:12975309,ECO:0000269|PubMed:14702039;Dbxref=dbSNP:rs736118,PMID:11358845,PMID:12975309,PMID:14702039 Q9BX79 UniProtKB Natural variant 638 638 . . . ID=VAR_060205;Note=In anophthalmia/microphthalmia. R->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19309693;Dbxref=dbSNP:rs144691445,PMID:19309693 Q9BX79 UniProtKB Natural variant 644 644 . . . ID=VAR_037174;Note=In MCOPS9%3B loss of tyrosine phosphorylation. T->M;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:17273977,ECO:0000269|PubMed:21368206;Dbxref=dbSNP:rs118203960,PMID:17273977,PMID:21368206 Q9BX79 UniProtKB Natural variant 655 655 . . . ID=VAR_037175;Note=In MCOPS9. R->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17273977;Dbxref=dbSNP:rs118203959,PMID:17273977 Q9BX79 UniProtKB Mutagenesis 255 255 . . . Note=Loss of interaction with RBP1. L->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22665496;Dbxref=PMID:22665496 Q9BX79 UniProtKB Mutagenesis 643 643 . . . Note=Loss of tyrosine phosphorylation. Y->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21368206;Dbxref=PMID:21368206 Q9BX79 UniProtKB Sequence conflict 95 95 . . . Note=A->V;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q9BX79 UniProtKB Sequence conflict 408 408 . . . Note=R->Q;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q9BX79 UniProtKB Sequence conflict 417 417 . . . Note=I->M;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q9BX79 UniProtKB Sequence conflict 635 635 . . . Note=G->S;Ontology_term=ECO:0000305;evidence=ECO:0000305