Q9BX73 (TM2D2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
TM2 domain-containing protein 2

Alternative name(s):
Beta-amyloid-binding protein-like protein 1
Short name=BBP-like protein 1

Gene names

Name:	TM2D2
Synonyms:	BLP1

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	214 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subcellular location	Membrane; Multi-pass membrane protein Potential.
Tissue specificity	Widely expressed. Ref.1
Sequence similarities	Belongs to the TM2 family.

Ontologies

Keywords
Cellular component	Membrane
Coding sequence diversity	Alternative splicing
Domain	Signal Transmembrane Transmembrane helix
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9BX73-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9BX73-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-76: MVLGGCPVSY...HSPVILCSYL → MKKCLLPVLITCMQTAICKDRMMMIMILLVNYR

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 35	35	Potential
	Chain	36 – 214	179	TM2 domain-containing protein 2		PRO_0000298982
Regions
	Transmembrane	145 – 165	21	Helical; Potential
	Transmembrane	183 – 203	21	Helical; Potential
Amino acid modifications
	Glycosylation	92	1	N-linked (GlcNAc...) Potential
Natural variations
	Alternative sequence	1 – 76	76	MVLGG…LCSYL → MKKCLLPVLITCMQTAICKD RMMMIMILLVNYR in isoform 2.		VSP_027495

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified June 1, 2001. Version 1. Checksum: BB928712AF2F78A8	FASTA	214	22,871
	10 20 30 40 50 60 MVLGGCPVSY LLLCGQAALL LGNLLLLHCV SRSHSQNATA EPELTSAGAA QPEGPGGAAS 70 80 90 100 110 120 WEYGDPHSPV ILCSYLPDEF IECEDPVDHV GNATASQELG YGCLKFGGQA YSDVEHTSVQ 130 140 150 160 170 180 CHALDGIECA SPRTFLRENK PCIKYTGHYF ITTLLYSFFL GCFGVDRFCL GHTGTAVGKL 190 200 210 LTLGGLGIWW FVDLILLITG GLMPSDGSNW CTVY
	Isoform 2 [UniParc]. Checksum: CD9F9F7CEE5CB388	FASTA	171	19,012
	10 20 30 40 50 60 MKKCLLPVLI TCMQTAICKD RMMMIMILLV NYRPDEFIEC EDPVDHVGNA TASQELGYGC 70 80 90 100 110 120 LKFGGQAYSD VEHTSVQCHA LDGIECASPR TFLRENKPCI KYTGHYFITT LLYSFFLGCF 130 140 150 160 170 GVDRFCLGHT GTAVGKLLTL GGLGIWWFVD LILLITGGLM PSDGSNWCTV Y

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Beta-amyloid peptide-induced apoptosis regulated by a novel protein containing a G protein activation module." Kajkowski E.M., Lo C.F., Ning X., Walker S., Sofia H.J., Wang W., Edris W., Chanda P., Wagner E., Vile S., Ryan K., McHendry-Rinde B., Smith S.C., Wood A., Rhodes K.J., Kennedy J.D., Bard J., Jacobsen J.S., Ozenberger B.A. J. Biol. Chem. 276:18748-18756(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2). Tissue: Ovary and Placenta.
[3]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Testis.
[4]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2). Tissue: Pancreas.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF353991 mRNA. Translation: AAK35065.1. AK075027 mRNA. Translation: BAC11359.1. AK075155 mRNA. Translation: BAC11437.1. AK314703 mRNA. Translation: BAG37251.1. AL834224 mRNA. Translation: CAH10695.1. CH471080 Genomic DNA. Translation: EAW63286.1. CH471080 Genomic DNA. Translation: EAW63288.1. CH471080 Genomic DNA. Translation: EAW63287.1. BC004878 mRNA. Translation: AAH04878.2. BC109049 mRNA. Translation: AAI09050.1. BC109050 mRNA. Translation: AAI09051.1.
IPI	IPI00032696. IPI00418667.
RefSeq	NP_001019551.1. NM_001024380.1. NP_001019552.1. NM_001024381.1. NP_114146.3. NM_031940.3. NP_510882.1. NM_078473.2.
UniGene	Hs.7471.
3D structure databases
ProteinModelPortal	Q9BX73.
ModBase	Search...
Protein-protein interaction databases
MINT	MINT-8201757.
STRING	9606.ENSP00000416050.
Polymorphism databases
DMDM	74733464.
Proteomic databases
PaxDb	Q9BX73.
PRIDE	Q9BX73.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000397070; ENSP00000380260; ENSG00000169490. ENST00000412303; ENSP00000402964; ENSG00000169490. ENST00000456397; ENSP00000416050; ENSG00000169490. ENST00000456845; ENSP00000391674; ENSG00000169490.
GeneID	83877.
KEGG	hsa:83877.
UCSC	uc003xmk.3. human. uc003xml.3. human.
Organism-specific databases
CTD	83877.
GeneCards	GC08M038846.
HGNC	HGNC:24127. TM2D2.
HPA	HPA047152. HPA050547.
MIM	610081. gene.
neXtProt	NX_Q9BX73.
PharmGKB	PA142670799.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG281716.
HOGENOM	HOG000007596.
HOVERGEN	HBG071725.
InParanoid	Q9BX73.
OMA	EDGSNWN.
OrthoDB	EOG4ZCT5H.
PhylomeDB	Q9BX73.
Gene expression databases
ArrayExpress	Q9BX73.
Bgee	Q9BX73.
CleanEx	HS_TM2D2.
Genevestigator	Q9BX73.
Family and domain databases
InterPro	IPR007829. TM2. [Graphical view]
Pfam	PF05154. TM2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	TM2D2. human.
GenomeRNAi	83877.
NextBio	72921.
SOURCE	Search...

Entry information

Entry name

TM2D2_HUMAN

Accession

Primary (citable) accession number: Q9BX73
Secondary accession number(s): B2RBK4, D3DSX8, Q8N0X9

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 11, 2007
Last sequence update:	June 1, 2001
Last modified:	May 29, 2013
This is version 73 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.