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Q9BX70

- BTBD2_HUMAN

UniProt

Q9BX70 - BTBD2_HUMAN

Protein

BTB/POZ domain-containing protein 2

Gene

BTBD2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 114 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. protein binding Source: UniProtKB

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    BTB/POZ domain-containing protein 2
    Gene namesi
    Name:BTBD2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:15504. BTBD2.

    Subcellular locationi

    CytoplasmP-body 1 Publication
    Note: Cytoplasmic bodies.

    GO - Cellular componenti

    1. cytoplasmic mRNA processing body Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA25439.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 525525BTB/POZ domain-containing protein 2PRO_0000186210Add
    BLAST

    Proteomic databases

    MaxQBiQ9BX70.
    PaxDbiQ9BX70.
    PRIDEiQ9BX70.

    PTM databases

    PhosphoSiteiQ9BX70.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9BX70.
    BgeeiQ9BX70.
    GenevestigatoriQ9BX70.

    Interactioni

    Subunit structurei

    Interacts with topoisomerase 1 and with TRIM5 isoform Delta.2 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    COPS6Q7L5N12EBI-710091,EBI-486838
    TP53P046372EBI-710091,EBI-366083

    Protein-protein interaction databases

    BioGridi120778. 30 interactions.
    IntActiQ9BX70. 30 interactions.
    MINTiMINT-1185053.

    Structurei

    Secondary structure

    1
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi372 – 3754
    Beta strandi378 – 3847
    Beta strandi391 – 3999
    Beta strandi401 – 4099
    Beta strandi411 – 42616
    Turni427 – 4304
    Beta strandi431 – 44212
    Beta strandi448 – 45912
    Beta strandi465 – 47410
    Beta strandi476 – 4816
    Beta strandi484 – 4896
    Turni491 – 4933
    Beta strandi496 – 5027
    Beta strandi506 – 5083
    Beta strandi513 – 5175
    Beta strandi520 – 5256

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3NO8X-ray2.20A/B361-525[»]
    ProteinModelPortaliQ9BX70.
    SMRiQ9BX70. Positions 110-322, 370-525.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ9BX70.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini117 – 18771BTBPROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi41 – 5414Poly-AlaAdd
    BLAST

    Sequence similaritiesi

    Contains 1 BTB (POZ) domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG308618.
    HOVERGENiHBG050743.
    InParanoidiQ9BX70.
    KOiK10477.
    OMAiSTGTKTC.
    OrthoDBiEOG73BVC6.
    PhylomeDBiQ9BX70.
    TreeFamiTF106482.

    Family and domain databases

    Gene3Di3.30.710.10. 1 hit.
    InterProiIPR011705. BACK.
    IPR000210. BTB/POZ-like.
    IPR011333. BTB/POZ_fold.
    IPR013069. BTB_POZ.
    IPR012983. PHR.
    [Graphical view]
    PfamiPF07707. BACK. 1 hit.
    PF00651. BTB. 1 hit.
    PF08005. PHR. 1 hit.
    [Graphical view]
    SMARTiSM00875. BACK. 1 hit.
    SM00225. BTB. 1 hit.
    [Graphical view]
    SUPFAMiSSF54695. SSF54695. 1 hit.
    PROSITEiPS50097. BTB. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9BX70-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAAGGSGGRA SCPPGVGVGP GTGGSPGPSA NAAATPAPGN AAAAAAAAAA    50
    AAAAPGPTPP APPGPGTDAQ AAGAERAEEA AGPGAAALQR EAAYNWQASK 100
    PTVQERFAFL FNNEVLCDVH FLVGKGLSSQ RIPAHRFVLA VGSAVFDAMF 150
    NGGMATTSTE IELPDVEPAA FLALLKFLYS DEVQIGPETV MTTLYTAKKY 200
    AVPALEAHCV EFLKKNLRAD NAFMLLTQAR LFDEPQLASL CLENIDKNTA 250
    DAITAEGFTD IDLDTLVAVL ERDTLGIREV RLFNAVVRWS EAECQRQQLQ 300
    VTPENRRKVL GKALGLIRFP LMTIEEFAAG PAQSGILVDR EVVSLFLHFT 350
    VNPKPRVEFI DRPRCCLRGK ECSINRFQQV ESRWGYSGTS DRIRFSVNKR 400
    IFVVGFGLYG SIHGPTDYQV NIQIIHTDSN TVLGQNDTGF SCDGSASTFR 450
    VMFKEPVEVL PNVNYTACAT LKGPDSHYGT KGLRKVTHES PTTGAKTCFT 500
    FCYAAGNNNG TSVEDGQIPE VIFYT 525
    Length:525
    Mass (Da):55,931
    Last modified:June 1, 2001 - v1
    Checksum:i5F4856161702A65D
    GO
    Isoform 2 (identifier: Q9BX70-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-321: Missing.

    Show »
    Length:204
    Mass (Da):22,566
    Checksum:i08727FE5DF916D4C
    GO

    Sequence cautioni

    The sequence BAB55143.1 differs from that shown. Reason: Erroneous initiation.
    The sequence AAC16070.1 differs from that shown. Reason: Erroneous gene model prediction.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti307 – 3071R → L in CAB96527. 1 PublicationCurated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 321321Missing in isoform 2. 2 PublicationsVSP_010562Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF355797 mRNA. Translation: AAK25826.1.
    AK000393 mRNA. Translation: BAA91136.1.
    AK027481 mRNA. Translation: BAB55143.1. Different initiation.
    CR457230 mRNA. Translation: CAG33511.1.
    AC004678 Genomic DNA. Translation: AAC16070.1. Sequence problems.
    AC005306 Genomic DNA. Translation: AAC26984.1.
    AC005306 Genomic DNA. Translation: AAG45443.1.
    BC000564 mRNA. Translation: AAH00564.2.
    BC008035 mRNA. Translation: AAH08035.2.
    BC053986 mRNA. Translation: AAH53986.1.
    BC094820 mRNA. Translation: AAH94820.1.
    AL360275 mRNA. Translation: CAB96527.1.
    CCDSiCCDS12078.1. [Q9BX70-1]
    RefSeqiNP_060267.2. NM_017797.3. [Q9BX70-1]
    UniGeneiHs.465543.

    Genome annotation databases

    EnsembliENST00000255608; ENSP00000255608; ENSG00000133243. [Q9BX70-1]
    GeneIDi55643.
    KEGGihsa:55643.
    UCSCiuc002luo.1. human. [Q9BX70-2]
    uc002lup.1. human. [Q9BX70-1]

    Polymorphism databases

    DMDMi20137455.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF355797 mRNA. Translation: AAK25826.1 .
    AK000393 mRNA. Translation: BAA91136.1 .
    AK027481 mRNA. Translation: BAB55143.1 . Different initiation.
    CR457230 mRNA. Translation: CAG33511.1 .
    AC004678 Genomic DNA. Translation: AAC16070.1 . Sequence problems.
    AC005306 Genomic DNA. Translation: AAC26984.1 .
    AC005306 Genomic DNA. Translation: AAG45443.1 .
    BC000564 mRNA. Translation: AAH00564.2 .
    BC008035 mRNA. Translation: AAH08035.2 .
    BC053986 mRNA. Translation: AAH53986.1 .
    BC094820 mRNA. Translation: AAH94820.1 .
    AL360275 mRNA. Translation: CAB96527.1 .
    CCDSi CCDS12078.1. [Q9BX70-1 ]
    RefSeqi NP_060267.2. NM_017797.3. [Q9BX70-1 ]
    UniGenei Hs.465543.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3NO8 X-ray 2.20 A/B 361-525 [» ]
    ProteinModelPortali Q9BX70.
    SMRi Q9BX70. Positions 110-322, 370-525.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 120778. 30 interactions.
    IntActi Q9BX70. 30 interactions.
    MINTi MINT-1185053.

    PTM databases

    PhosphoSitei Q9BX70.

    Polymorphism databases

    DMDMi 20137455.

    Proteomic databases

    MaxQBi Q9BX70.
    PaxDbi Q9BX70.
    PRIDEi Q9BX70.

    Protocols and materials databases

    DNASUi 55643.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000255608 ; ENSP00000255608 ; ENSG00000133243 . [Q9BX70-1 ]
    GeneIDi 55643.
    KEGGi hsa:55643.
    UCSCi uc002luo.1. human. [Q9BX70-2 ]
    uc002lup.1. human. [Q9BX70-1 ]

    Organism-specific databases

    CTDi 55643.
    GeneCardsi GC19M001985.
    H-InvDB HIX0040331.
    HGNCi HGNC:15504. BTBD2.
    MIMi 608531. gene.
    neXtProti NX_Q9BX70.
    PharmGKBi PA25439.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG308618.
    HOVERGENi HBG050743.
    InParanoidi Q9BX70.
    KOi K10477.
    OMAi STGTKTC.
    OrthoDBi EOG73BVC6.
    PhylomeDBi Q9BX70.
    TreeFami TF106482.

    Miscellaneous databases

    EvolutionaryTracei Q9BX70.
    GeneWikii BTBD2.
    GenomeRNAii 55643.
    NextBioi 60330.
    PROi Q9BX70.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9BX70.
    Bgeei Q9BX70.
    Genevestigatori Q9BX70.

    Family and domain databases

    Gene3Di 3.30.710.10. 1 hit.
    InterProi IPR011705. BACK.
    IPR000210. BTB/POZ-like.
    IPR011333. BTB/POZ_fold.
    IPR013069. BTB_POZ.
    IPR012983. PHR.
    [Graphical view ]
    Pfami PF07707. BACK. 1 hit.
    PF00651. BTB. 1 hit.
    PF08005. PHR. 1 hit.
    [Graphical view ]
    SMARTi SM00875. BACK. 1 hit.
    SM00225. BTB. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54695. SSF54695. 1 hit.
    PROSITEi PS50097. BTB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Characterization of BTBD1 and BTBD2, two similar BTB-domain-containing Kelch-like proteins that interact with topoisomerase I."
      Xu L., Yang L., Hashimoto K., Anderson M., Kohlhagen G., Pommier Y., D'Arpa P.
      BMC Genomics 3:1-1(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), INTERACTION WITH TOP1, TISSUE SPECIFICITY.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 214-525 (ISOFORM 1).
      Tissue: Teratocarcinoma.
    3. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    4. "The DNA sequence and biology of human chromosome 19."
      Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
      , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
      Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 90-525 (ISOFORM 1).
      Tissue: Blood, Brain, Colon and Ovary.
    6. The European IMAGE consortium
      Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 258-525 (ISOFORM 1).
    7. "BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta."
      Xu L., Yang L., Moitra P.K., Hashimoto K., Rallabhandi P., Kaul S., Meroni G., Jensen J.P., Weissman A.M., D'Arpa P.
      Exp. Cell Res. 288:84-93(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION, INTERACTION WITH TRIM5.
    8. "Crystal structure of the PHR domain from human BTBD2 protein."
      New York structural genomix research consortium (NYSGXRC)
      Submitted (AUG-2010) to the PDB data bank
      Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) OF 361-525.

    Entry informationi

    Entry nameiBTBD2_HUMAN
    AccessioniPrimary (citable) accession number: Q9BX70
    Secondary accession number(s): O60418
    , O75248, Q4VBZ1, Q6IAC5, Q7Z5W0, Q96SX8, Q9NPS1, Q9NX81
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 23, 2002
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 114 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3