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Protein

BTB/POZ domain-containing protein 2

Gene

BTBD2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000133243-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
BTB/POZ domain-containing protein 2
Gene namesi
Name:BTBD2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:15504. BTBD2.

Subcellular locationi

GO - Cellular componenti

  • cytoplasmic mRNA processing body Source: UniProtKB
  • SCF ubiquitin ligase complex Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi55643.
OpenTargetsiENSG00000133243.
PharmGKBiPA25439.

Polymorphism and mutation databases

BioMutaiBTBD2.
DMDMi20137455.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001862101 – 525BTB/POZ domain-containing protein 2Add BLAST525

Proteomic databases

EPDiQ9BX70.
MaxQBiQ9BX70.
PaxDbiQ9BX70.
PeptideAtlasiQ9BX70.
PRIDEiQ9BX70.

PTM databases

iPTMnetiQ9BX70.
PhosphoSitePlusiQ9BX70.

Expressioni

Gene expression databases

BgeeiENSG00000133243.
ExpressionAtlasiQ9BX70. baseline and differential.
GenevisibleiQ9BX70. HS.

Organism-specific databases

HPAiCAB011478.

Interactioni

Subunit structurei

Interacts with topoisomerase 1 and with TRIM5 isoform Delta.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
COPS6Q7L5N12EBI-710091,EBI-486838
TP53P046372EBI-710091,EBI-366083

GO - Molecular functioni

Protein-protein interaction databases

BioGridi120778. 36 interactors.
IntActiQ9BX70. 33 interactors.
MINTiMINT-1185053.
STRINGi9606.ENSP00000255608.

Structurei

Secondary structure

1525
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi372 – 375Combined sources4
Beta strandi378 – 384Combined sources7
Beta strandi391 – 399Combined sources9
Beta strandi401 – 409Combined sources9
Beta strandi411 – 426Combined sources16
Turni427 – 430Combined sources4
Beta strandi431 – 442Combined sources12
Beta strandi448 – 459Combined sources12
Beta strandi465 – 474Combined sources10
Beta strandi476 – 481Combined sources6
Beta strandi484 – 489Combined sources6
Turni491 – 493Combined sources3
Beta strandi496 – 502Combined sources7
Beta strandi506 – 508Combined sources3
Beta strandi513 – 517Combined sources5
Beta strandi520 – 525Combined sources6

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3NO8X-ray2.20A/B361-525[»]
ProteinModelPortaliQ9BX70.
SMRiQ9BX70.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9BX70.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini117 – 187BTBPROSITE-ProRule annotationAdd BLAST71

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi41 – 54Poly-AlaAdd BLAST14

Sequence similaritiesi

Contains 1 BTB (POZ) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG2075. Eukaryota.
ENOG410XQ3X. LUCA.
GeneTreeiENSGT00550000074511.
HOVERGENiHBG050743.
InParanoidiQ9BX70.
KOiK10477.
OMAiSTGTKTC.
OrthoDBiEOG091G04LD.
PhylomeDBiQ9BX70.
TreeFamiTF106482.

Family and domain databases

InterProiIPR011705. BACK.
IPR000210. BTB/POZ_dom.
IPR012983. PHR.
IPR011333. SKP1/BTB/POZ.
[Graphical view]
PfamiPF07707. BACK. 1 hit.
PF00651. BTB. 1 hit.
PF08005. PHR. 1 hit.
[Graphical view]
SMARTiSM00875. BACK. 1 hit.
SM00225. BTB. 1 hit.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9BX70-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAGGSGGRA SCPPGVGVGP GTGGSPGPSA NAAATPAPGN AAAAAAAAAA
60 70 80 90 100
AAAAPGPTPP APPGPGTDAQ AAGAERAEEA AGPGAAALQR EAAYNWQASK
110 120 130 140 150
PTVQERFAFL FNNEVLCDVH FLVGKGLSSQ RIPAHRFVLA VGSAVFDAMF
160 170 180 190 200
NGGMATTSTE IELPDVEPAA FLALLKFLYS DEVQIGPETV MTTLYTAKKY
210 220 230 240 250
AVPALEAHCV EFLKKNLRAD NAFMLLTQAR LFDEPQLASL CLENIDKNTA
260 270 280 290 300
DAITAEGFTD IDLDTLVAVL ERDTLGIREV RLFNAVVRWS EAECQRQQLQ
310 320 330 340 350
VTPENRRKVL GKALGLIRFP LMTIEEFAAG PAQSGILVDR EVVSLFLHFT
360 370 380 390 400
VNPKPRVEFI DRPRCCLRGK ECSINRFQQV ESRWGYSGTS DRIRFSVNKR
410 420 430 440 450
IFVVGFGLYG SIHGPTDYQV NIQIIHTDSN TVLGQNDTGF SCDGSASTFR
460 470 480 490 500
VMFKEPVEVL PNVNYTACAT LKGPDSHYGT KGLRKVTHES PTTGAKTCFT
510 520
FCYAAGNNNG TSVEDGQIPE VIFYT
Length:525
Mass (Da):55,931
Last modified:June 1, 2001 - v1
Checksum:i5F4856161702A65D
GO
Isoform 2 (identifier: Q9BX70-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-321: Missing.

Show »
Length:204
Mass (Da):22,566
Checksum:i08727FE5DF916D4C
GO

Sequence cautioni

The sequence AAC16070 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence BAB55143 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti307R → L in CAB96527 (Ref. 6) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0105621 – 321Missing in isoform 2. 2 PublicationsAdd BLAST321

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF355797 mRNA. Translation: AAK25826.1.
AK000393 mRNA. Translation: BAA91136.1.
AK027481 mRNA. Translation: BAB55143.1. Different initiation.
CR457230 mRNA. Translation: CAG33511.1.
AC004678 Genomic DNA. Translation: AAC16070.1. Sequence problems.
AC005306 Genomic DNA. Translation: AAC26984.1.
AC005306 Genomic DNA. Translation: AAG45443.1.
BC000564 mRNA. Translation: AAH00564.2.
BC008035 mRNA. Translation: AAH08035.2.
BC053986 mRNA. Translation: AAH53986.1.
BC094820 mRNA. Translation: AAH94820.1.
AL360275 mRNA. Translation: CAB96527.1.
CCDSiCCDS12078.1. [Q9BX70-1]
RefSeqiNP_060267.2. NM_017797.3. [Q9BX70-1]
XP_011526429.1. XM_011528127.1. [Q9BX70-2]
UniGeneiHs.465543.

Genome annotation databases

EnsembliENST00000255608; ENSP00000255608; ENSG00000133243. [Q9BX70-1]
GeneIDi55643.
KEGGihsa:55643.
UCSCiuc002lup.2. human. [Q9BX70-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF355797 mRNA. Translation: AAK25826.1.
AK000393 mRNA. Translation: BAA91136.1.
AK027481 mRNA. Translation: BAB55143.1. Different initiation.
CR457230 mRNA. Translation: CAG33511.1.
AC004678 Genomic DNA. Translation: AAC16070.1. Sequence problems.
AC005306 Genomic DNA. Translation: AAC26984.1.
AC005306 Genomic DNA. Translation: AAG45443.1.
BC000564 mRNA. Translation: AAH00564.2.
BC008035 mRNA. Translation: AAH08035.2.
BC053986 mRNA. Translation: AAH53986.1.
BC094820 mRNA. Translation: AAH94820.1.
AL360275 mRNA. Translation: CAB96527.1.
CCDSiCCDS12078.1. [Q9BX70-1]
RefSeqiNP_060267.2. NM_017797.3. [Q9BX70-1]
XP_011526429.1. XM_011528127.1. [Q9BX70-2]
UniGeneiHs.465543.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3NO8X-ray2.20A/B361-525[»]
ProteinModelPortaliQ9BX70.
SMRiQ9BX70.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120778. 36 interactors.
IntActiQ9BX70. 33 interactors.
MINTiMINT-1185053.
STRINGi9606.ENSP00000255608.

PTM databases

iPTMnetiQ9BX70.
PhosphoSitePlusiQ9BX70.

Polymorphism and mutation databases

BioMutaiBTBD2.
DMDMi20137455.

Proteomic databases

EPDiQ9BX70.
MaxQBiQ9BX70.
PaxDbiQ9BX70.
PeptideAtlasiQ9BX70.
PRIDEiQ9BX70.

Protocols and materials databases

DNASUi55643.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000255608; ENSP00000255608; ENSG00000133243. [Q9BX70-1]
GeneIDi55643.
KEGGihsa:55643.
UCSCiuc002lup.2. human. [Q9BX70-1]

Organism-specific databases

CTDi55643.
DisGeNETi55643.
GeneCardsiBTBD2.
H-InvDBHIX0040331.
HGNCiHGNC:15504. BTBD2.
HPAiCAB011478.
MIMi608531. gene.
neXtProtiNX_Q9BX70.
OpenTargetsiENSG00000133243.
PharmGKBiPA25439.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2075. Eukaryota.
ENOG410XQ3X. LUCA.
GeneTreeiENSGT00550000074511.
HOVERGENiHBG050743.
InParanoidiQ9BX70.
KOiK10477.
OMAiSTGTKTC.
OrthoDBiEOG091G04LD.
PhylomeDBiQ9BX70.
TreeFamiTF106482.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000133243-MONOMER.

Miscellaneous databases

ChiTaRSiBTBD2. human.
EvolutionaryTraceiQ9BX70.
GeneWikiiBTBD2.
GenomeRNAii55643.
PROiQ9BX70.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000133243.
ExpressionAtlasiQ9BX70. baseline and differential.
GenevisibleiQ9BX70. HS.

Family and domain databases

InterProiIPR011705. BACK.
IPR000210. BTB/POZ_dom.
IPR012983. PHR.
IPR011333. SKP1/BTB/POZ.
[Graphical view]
PfamiPF07707. BACK. 1 hit.
PF00651. BTB. 1 hit.
PF08005. PHR. 1 hit.
[Graphical view]
SMARTiSM00875. BACK. 1 hit.
SM00225. BTB. 1 hit.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiBTBD2_HUMAN
AccessioniPrimary (citable) accession number: Q9BX70
Secondary accession number(s): O60418
, O75248, Q4VBZ1, Q6IAC5, Q7Z5W0, Q96SX8, Q9NPS1, Q9NX81
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: June 1, 2001
Last modified: November 2, 2016
This is version 132 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.