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Protein

BTB/POZ domain-containing protein 2

Gene

BTBD2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
BTB/POZ domain-containing protein 2
Gene namesi
Name:BTBD2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000133243.8
HGNCiHGNC:15504 BTBD2
MIMi608531 gene
neXtProtiNX_Q9BX70

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi55643
OpenTargetsiENSG00000133243
PharmGKBiPA25439

Polymorphism and mutation databases

BioMutaiBTBD2
DMDMi20137455

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001862101 – 525BTB/POZ domain-containing protein 2Add BLAST525

Proteomic databases

EPDiQ9BX70
MaxQBiQ9BX70
PaxDbiQ9BX70
PeptideAtlasiQ9BX70
PRIDEiQ9BX70
ProteomicsDBi79370
79371 [Q9BX70-2]

PTM databases

iPTMnetiQ9BX70
PhosphoSitePlusiQ9BX70

Expressioni

Gene expression databases

BgeeiENSG00000133243
ExpressionAtlasiQ9BX70 baseline and differential
GenevisibleiQ9BX70 HS

Interactioni

Subunit structurei

Interacts with topoisomerase 1 and with TRIM5 isoform Delta.2 Publications

Binary interactionsi

Show more details

GO - Molecular functioni

Protein-protein interaction databases

BioGridi120778, 36 interactors
IntActiQ9BX70, 41 interactors
MINTiQ9BX70
STRINGi9606.ENSP00000255608

Structurei

Secondary structure

1525
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi372 – 375Combined sources4
Beta strandi378 – 384Combined sources7
Beta strandi391 – 399Combined sources9
Beta strandi401 – 409Combined sources9
Beta strandi411 – 426Combined sources16
Turni427 – 430Combined sources4
Beta strandi431 – 442Combined sources12
Beta strandi448 – 459Combined sources12
Beta strandi465 – 474Combined sources10
Beta strandi476 – 481Combined sources6
Beta strandi484 – 489Combined sources6
Turni491 – 493Combined sources3
Beta strandi496 – 502Combined sources7
Beta strandi506 – 508Combined sources3
Beta strandi513 – 517Combined sources5
Beta strandi520 – 525Combined sources6

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3NO8X-ray2.20A/B361-525[»]
ProteinModelPortaliQ9BX70
SMRiQ9BX70
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9BX70

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini117 – 187BTBPROSITE-ProRule annotationAdd BLAST71

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi41 – 54Poly-AlaAdd BLAST14

Phylogenomic databases

eggNOGiKOG2075 Eukaryota
ENOG410XQ3X LUCA
GeneTreeiENSGT00550000074511
HOVERGENiHBG050743
InParanoidiQ9BX70
KOiK10477
OMAiCDGSANT
OrthoDBiEOG091G04LD
PhylomeDBiQ9BX70
TreeFamiTF106482

Family and domain databases

Gene3Di2.60.120.820, 1 hit
InterProiView protein in InterPro
IPR011705 BACK
IPR000210 BTB/POZ_dom
IPR012983 PHR
IPR038648 PHR_sf
IPR011333 SKP1/BTB/POZ_sf
PfamiView protein in Pfam
PF07707 BACK, 1 hit
PF00651 BTB, 1 hit
PF08005 PHR, 1 hit
SMARTiView protein in SMART
SM00875 BACK, 1 hit
SM00225 BTB, 1 hit
SUPFAMiSSF54695 SSF54695, 1 hit
PROSITEiView protein in PROSITE
PS50097 BTB, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9BX70-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAGGSGGRA SCPPGVGVGP GTGGSPGPSA NAAATPAPGN AAAAAAAAAA
60 70 80 90 100
AAAAPGPTPP APPGPGTDAQ AAGAERAEEA AGPGAAALQR EAAYNWQASK
110 120 130 140 150
PTVQERFAFL FNNEVLCDVH FLVGKGLSSQ RIPAHRFVLA VGSAVFDAMF
160 170 180 190 200
NGGMATTSTE IELPDVEPAA FLALLKFLYS DEVQIGPETV MTTLYTAKKY
210 220 230 240 250
AVPALEAHCV EFLKKNLRAD NAFMLLTQAR LFDEPQLASL CLENIDKNTA
260 270 280 290 300
DAITAEGFTD IDLDTLVAVL ERDTLGIREV RLFNAVVRWS EAECQRQQLQ
310 320 330 340 350
VTPENRRKVL GKALGLIRFP LMTIEEFAAG PAQSGILVDR EVVSLFLHFT
360 370 380 390 400
VNPKPRVEFI DRPRCCLRGK ECSINRFQQV ESRWGYSGTS DRIRFSVNKR
410 420 430 440 450
IFVVGFGLYG SIHGPTDYQV NIQIIHTDSN TVLGQNDTGF SCDGSASTFR
460 470 480 490 500
VMFKEPVEVL PNVNYTACAT LKGPDSHYGT KGLRKVTHES PTTGAKTCFT
510 520
FCYAAGNNNG TSVEDGQIPE VIFYT
Length:525
Mass (Da):55,931
Last modified:June 1, 2001 - v1
Checksum:i5F4856161702A65D
GO
Isoform 2 (identifier: Q9BX70-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-321: Missing.

Show »
Length:204
Mass (Da):22,566
Checksum:i08727FE5DF916D4C
GO

Sequence cautioni

The sequence AAC16070 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence BAB55143 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti307R → L in CAB96527 (Ref. 6) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0105621 – 321Missing in isoform 2. 2 PublicationsAdd BLAST321

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF355797 mRNA Translation: AAK25826.1
AK000393 mRNA Translation: BAA91136.1
AK027481 mRNA Translation: BAB55143.1 Different initiation.
CR457230 mRNA Translation: CAG33511.1
AC004678 Genomic DNA Translation: AAC16070.1 Sequence problems.
AC005306 Genomic DNA Translation: AAC26984.1
AC005306 Genomic DNA Translation: AAG45443.1
BC000564 mRNA Translation: AAH00564.2
BC008035 mRNA Translation: AAH08035.2
BC053986 mRNA Translation: AAH53986.1
BC094820 mRNA Translation: AAH94820.1
AL360275 mRNA Translation: CAB96527.1
CCDSiCCDS12078.1 [Q9BX70-1]
RefSeqiNP_060267.2, NM_017797.3 [Q9BX70-1]
XP_011526429.1, XM_011528127.1 [Q9BX70-2]
UniGeneiHs.465543

Genome annotation databases

EnsembliENST00000255608; ENSP00000255608; ENSG00000133243 [Q9BX70-1]
GeneIDi55643
KEGGihsa:55643
UCSCiuc002lup.2 human [Q9BX70-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiBTBD2_HUMAN
AccessioniPrimary (citable) accession number: Q9BX70
Secondary accession number(s): O60418
, O75248, Q4VBZ1, Q6IAC5, Q7Z5W0, Q96SX8, Q9NPS1, Q9NX81
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: June 1, 2001
Last modified: June 20, 2018
This is version 143 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

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