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Q9BX70

- BTBD2_HUMAN

UniProt

Q9BX70 - BTBD2_HUMAN

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Protein
BTB/POZ domain-containing protein 2
Gene
BTBD2
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. protein binding Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
BTB/POZ domain-containing protein 2
Gene namesi
Name:BTBD2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:15504. BTBD2.

Subcellular locationi

CytoplasmP-body
Note: Cytoplasmic bodies.1 Publication

GO - Cellular componenti

  1. cytoplasmic mRNA processing body Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA25439.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 525525BTB/POZ domain-containing protein 2
PRO_0000186210Add
BLAST

Proteomic databases

MaxQBiQ9BX70.
PaxDbiQ9BX70.
PRIDEiQ9BX70.

PTM databases

PhosphoSiteiQ9BX70.

Expressioni

Gene expression databases

ArrayExpressiQ9BX70.
BgeeiQ9BX70.
GenevestigatoriQ9BX70.

Interactioni

Subunit structurei

Interacts with topoisomerase 1 and with TRIM5 isoform Delta.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
COPS6Q7L5N12EBI-710091,EBI-486838
TP53P046372EBI-710091,EBI-366083

Protein-protein interaction databases

BioGridi120778. 30 interactions.
IntActiQ9BX70. 30 interactions.
MINTiMINT-1185053.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi372 – 3754
Beta strandi378 – 3847
Beta strandi391 – 3999
Beta strandi401 – 4099
Beta strandi411 – 42616
Turni427 – 4304
Beta strandi431 – 44212
Beta strandi448 – 45912
Beta strandi465 – 47410
Beta strandi476 – 4816
Beta strandi484 – 4896
Turni491 – 4933
Beta strandi496 – 5027
Beta strandi506 – 5083
Beta strandi513 – 5175
Beta strandi520 – 5256

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3NO8X-ray2.20A/B361-525[»]
ProteinModelPortaliQ9BX70.
SMRiQ9BX70. Positions 110-322, 370-525.

Miscellaneous databases

EvolutionaryTraceiQ9BX70.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini117 – 18771BTB
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi41 – 5414Poly-Ala
Add
BLAST

Sequence similaritiesi

Contains 1 BTB (POZ) domain.

Phylogenomic databases

eggNOGiNOG308618.
HOVERGENiHBG050743.
InParanoidiQ9BX70.
KOiK10477.
OMAiSTGTKTC.
OrthoDBiEOG73BVC6.
PhylomeDBiQ9BX70.
TreeFamiTF106482.

Family and domain databases

Gene3Di3.30.710.10. 1 hit.
InterProiIPR011705. BACK.
IPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR013069. BTB_POZ.
IPR012983. PHR.
[Graphical view]
PfamiPF07707. BACK. 1 hit.
PF00651. BTB. 1 hit.
PF08005. PHR. 1 hit.
[Graphical view]
SMARTiSM00875. BACK. 1 hit.
SM00225. BTB. 1 hit.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9BX70-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MAAGGSGGRA SCPPGVGVGP GTGGSPGPSA NAAATPAPGN AAAAAAAAAA    50
AAAAPGPTPP APPGPGTDAQ AAGAERAEEA AGPGAAALQR EAAYNWQASK 100
PTVQERFAFL FNNEVLCDVH FLVGKGLSSQ RIPAHRFVLA VGSAVFDAMF 150
NGGMATTSTE IELPDVEPAA FLALLKFLYS DEVQIGPETV MTTLYTAKKY 200
AVPALEAHCV EFLKKNLRAD NAFMLLTQAR LFDEPQLASL CLENIDKNTA 250
DAITAEGFTD IDLDTLVAVL ERDTLGIREV RLFNAVVRWS EAECQRQQLQ 300
VTPENRRKVL GKALGLIRFP LMTIEEFAAG PAQSGILVDR EVVSLFLHFT 350
VNPKPRVEFI DRPRCCLRGK ECSINRFQQV ESRWGYSGTS DRIRFSVNKR 400
IFVVGFGLYG SIHGPTDYQV NIQIIHTDSN TVLGQNDTGF SCDGSASTFR 450
VMFKEPVEVL PNVNYTACAT LKGPDSHYGT KGLRKVTHES PTTGAKTCFT 500
FCYAAGNNNG TSVEDGQIPE VIFYT 525
Length:525
Mass (Da):55,931
Last modified:June 1, 2001 - v1
Checksum:i5F4856161702A65D
GO
Isoform 2 (identifier: Q9BX70-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-321: Missing.

Show »
Length:204
Mass (Da):22,566
Checksum:i08727FE5DF916D4C
GO

Sequence cautioni

The sequence BAB55143.1 differs from that shown. Reason: Erroneous initiation.
The sequence AAC16070.1 differs from that shown. Reason: Erroneous gene model prediction.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 321321Missing in isoform 2.
VSP_010562Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti307 – 3071R → L in CAB96527. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF355797 mRNA. Translation: AAK25826.1.
AK000393 mRNA. Translation: BAA91136.1.
AK027481 mRNA. Translation: BAB55143.1. Different initiation.
CR457230 mRNA. Translation: CAG33511.1.
AC004678 Genomic DNA. Translation: AAC16070.1. Sequence problems.
AC005306 Genomic DNA. Translation: AAC26984.1.
AC005306 Genomic DNA. Translation: AAG45443.1.
BC000564 mRNA. Translation: AAH00564.2.
BC008035 mRNA. Translation: AAH08035.2.
BC053986 mRNA. Translation: AAH53986.1.
BC094820 mRNA. Translation: AAH94820.1.
AL360275 mRNA. Translation: CAB96527.1.
CCDSiCCDS12078.1. [Q9BX70-1]
RefSeqiNP_060267.2. NM_017797.3. [Q9BX70-1]
UniGeneiHs.465543.

Genome annotation databases

EnsembliENST00000255608; ENSP00000255608; ENSG00000133243. [Q9BX70-1]
GeneIDi55643.
KEGGihsa:55643.
UCSCiuc002luo.1. human. [Q9BX70-2]
uc002lup.1. human. [Q9BX70-1]

Polymorphism databases

DMDMi20137455.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF355797 mRNA. Translation: AAK25826.1 .
AK000393 mRNA. Translation: BAA91136.1 .
AK027481 mRNA. Translation: BAB55143.1 . Different initiation.
CR457230 mRNA. Translation: CAG33511.1 .
AC004678 Genomic DNA. Translation: AAC16070.1 . Sequence problems.
AC005306 Genomic DNA. Translation: AAC26984.1 .
AC005306 Genomic DNA. Translation: AAG45443.1 .
BC000564 mRNA. Translation: AAH00564.2 .
BC008035 mRNA. Translation: AAH08035.2 .
BC053986 mRNA. Translation: AAH53986.1 .
BC094820 mRNA. Translation: AAH94820.1 .
AL360275 mRNA. Translation: CAB96527.1 .
CCDSi CCDS12078.1. [Q9BX70-1 ]
RefSeqi NP_060267.2. NM_017797.3. [Q9BX70-1 ]
UniGenei Hs.465543.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3NO8 X-ray 2.20 A/B 361-525 [» ]
ProteinModelPortali Q9BX70.
SMRi Q9BX70. Positions 110-322, 370-525.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 120778. 30 interactions.
IntActi Q9BX70. 30 interactions.
MINTi MINT-1185053.

PTM databases

PhosphoSitei Q9BX70.

Polymorphism databases

DMDMi 20137455.

Proteomic databases

MaxQBi Q9BX70.
PaxDbi Q9BX70.
PRIDEi Q9BX70.

Protocols and materials databases

DNASUi 55643.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000255608 ; ENSP00000255608 ; ENSG00000133243 . [Q9BX70-1 ]
GeneIDi 55643.
KEGGi hsa:55643.
UCSCi uc002luo.1. human. [Q9BX70-2 ]
uc002lup.1. human. [Q9BX70-1 ]

Organism-specific databases

CTDi 55643.
GeneCardsi GC19M001985.
H-InvDB HIX0040331.
HGNCi HGNC:15504. BTBD2.
MIMi 608531. gene.
neXtProti NX_Q9BX70.
PharmGKBi PA25439.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG308618.
HOVERGENi HBG050743.
InParanoidi Q9BX70.
KOi K10477.
OMAi STGTKTC.
OrthoDBi EOG73BVC6.
PhylomeDBi Q9BX70.
TreeFami TF106482.

Miscellaneous databases

EvolutionaryTracei Q9BX70.
GeneWikii BTBD2.
GenomeRNAii 55643.
NextBioi 60330.
PROi Q9BX70.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9BX70.
Bgeei Q9BX70.
Genevestigatori Q9BX70.

Family and domain databases

Gene3Di 3.30.710.10. 1 hit.
InterProi IPR011705. BACK.
IPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR013069. BTB_POZ.
IPR012983. PHR.
[Graphical view ]
Pfami PF07707. BACK. 1 hit.
PF00651. BTB. 1 hit.
PF08005. PHR. 1 hit.
[Graphical view ]
SMARTi SM00875. BACK. 1 hit.
SM00225. BTB. 1 hit.
[Graphical view ]
SUPFAMi SSF54695. SSF54695. 1 hit.
PROSITEi PS50097. BTB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of BTBD1 and BTBD2, two similar BTB-domain-containing Kelch-like proteins that interact with topoisomerase I."
    Xu L., Yang L., Hashimoto K., Anderson M., Kohlhagen G., Pommier Y., D'Arpa P.
    BMC Genomics 3:1-1(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), INTERACTION WITH TOP1, TISSUE SPECIFICITY.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 214-525 (ISOFORM 1).
    Tissue: Teratocarcinoma.
  3. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
  4. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 90-525 (ISOFORM 1).
    Tissue: Blood, Brain, Colon and Ovary.
  6. The European IMAGE consortium
    Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 258-525 (ISOFORM 1).
  7. "BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta."
    Xu L., Yang L., Moitra P.K., Hashimoto K., Rallabhandi P., Kaul S., Meroni G., Jensen J.P., Weissman A.M., D'Arpa P.
    Exp. Cell Res. 288:84-93(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, INTERACTION WITH TRIM5.
  8. "Crystal structure of the PHR domain from human BTBD2 protein."
    New York structural genomix research consortium (NYSGXRC)
    Submitted (AUG-2010) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) OF 361-525.

Entry informationi

Entry nameiBTBD2_HUMAN
AccessioniPrimary (citable) accession number: Q9BX70
Secondary accession number(s): O60418
, O75248, Q4VBZ1, Q6IAC5, Q7Z5W0, Q96SX8, Q9NPS1, Q9NX81
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: June 1, 2001
Last modified: July 9, 2014
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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