Caspase recruitment domain-containing protein 6 - Homo sapiens (Human)

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Reviewed, UniProtKB/Swiss-Prot Q9BX69 (CARD6_HUMAN)

Last modified June 16, 2009. Version 49. History...

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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein names

Recommended name:
Caspase recruitment domain-containing protein 6

Gene names

Name:

CARD6

Organism

Homo sapiens (Human)

Taxonomic identifier

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	1037 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	May be involved in apoptosis.
Sequence similarities	Contains 1 CARD domain.

Ontologies

Keywords
Biological process	Apoptosis
Coding sequence diversity	Polymorphism
PTM	Phosphoprotein
Gene Ontology (GO)
Biological process	apoptosis Inferred from electronic annotation. Source: UniProtKB-KW regulation of apoptosis Inferred from electronic annotation. Source: InterPro
Cellular component	intracellular Inferred from electronic annotation. Source: InterPro
Molecular function	protein binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1037

Caspase recruitment domain-containing protein 6

PRO_0000144079

Regions

Domain

92

CARD

Compositional bias

81

Asp/Glu-rich

Compositional bias

56

Pro-rich

Amino acid modifications

Modified residue

1

Phosphoserine Ref.4

Natural variations

Natural variant

1

S → L: dbSNP rs10512747. Ref.1

VAR_046689

Natural variant

1

R → K: dbSNP rs7715491.

VAR_046690

Natural variant

1

M → K: dbSNP rs3812030.

VAR_046691

Natural variant

1

D → V: dbSNP rs3812031.

VAR_046692

Natural variant

1

A → D: dbSNP rs36085996.

VAR_046693

Natural variant

1

I → V: dbSNP rs323562.

VAR_046694

Sequences

Sequence

Length

Mass (Da)

Tools

Q9BX69-1 [UniParc].

Last modified October 14, 2008. Version 2.
Checksum: 366E64BE7AFF164C
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1,037

116,468

        10         20         30         40         50         60 
MATESTPSEI IERERKKLLE ILQHDPDSIL DTLTSRRLIS EEEYETLENV TDLLKKSRKL 

        70         80         90        100        110        120 
LILVQKKGEA TCQHFLKCLF STFPQSAAIC GLRHEVLKHE NTVPPQSMGA SSNSEDAFSP 

       130        140        150        160        170        180 
GIKQPEAPEI TVFFSEKEHL DLETSEFFRD KKTSYRETAL SARKNEKEYD TPEVTLSYSV 

       190        200        210        220        230        240 
EKVGCEVPAT ITYIKDGQRY EELDDSLYLG KEEYLGSVDT PEDAEATVEE EVYDDPEHVG 

       250        260        270        280        290        300 
YDGEEDFENS ETTEFSGEEP SYEGSETSLS LEEEQEKSIE ERKKVFKDVL LCLNMDRSRK 

       310        320        330        340        350        360 
VLPDFVKQFS LDRGCKWTPE SPGDLAWNFL MKVQARDVTA RDSILSHKVL DEDSKEDLLA 

       370        380        390        400        410        420 
GVENLEIRDI QTINPLDVLC ATMLCSDSSL QRQVMSNMYQ CQFALPLLLP DAENNKSILM 

       430        440        450        460        470        480 
LGAMKDIVKK QSTQFSGGPT EDTEKFLTLM KMPVISFVRL GYCSFSKSRI LNTLLSPAQL 

       490        500        510        520        530        540 
KLHKIFLHQD LPLLVLPRQI SDGLVEITWC FPDSDDRKEN PFFQKPVALA NLRGNLESFW 

       550        560        570        580        590        600 
TQFGFLMEVS SAVFFFTDCL GEKEWDLLMF LGEAAIERCY FVLSSQARES EEAQIFQRIL 

       610        620        630        640        650        660 
NLKPAQLLFW ERGDAGDRRK NMEGLQAALQ EVMFSSCLRC VSVEDMAALA RELGIQVDED 

       670        680        690        700        710        720 
FENTQRIQVS SGENMAGTAE GEGQQRHSQL KSSSKSQALM PIQEPGTQCE LSQNLQNLYG 

       730        740        750        760        770        780 
TPVFRPVLEN SWLFPTRIGG NFNHVSLKAS WVMGRPFGSE QRPKWFHPLP FQNAGAQGRG 

       790        800        810        820        830        840 
KSFGIQSFHP QIFYSGERFM KFSRVARGCH SNGTFGRLPR PICQHVQACP ERPQMMGTLE 

       850        860        870        880        890        900 
RSRAVASKIG HSYSLDSQPA RAVGKPWPQQ ACTRVTELTE ATGKLIRTSH IGKPHPQSFQ 

       910        920        930        940        950        960 
PAAATQKLRP ASQQGVQMKT QGGASNPALQ IGSHPMCKSS QFKSDQSNPS TVKHSQPKPF 

       970        980        990       1000       1010       1020 
HSVPSQPKSS QTKSCQSQPS QTKPSPCKST QPKPSQPWPP QSKPSQPRPP QPKSSSTNPS 

      1030 
QAKAHHSKAG QKRGGKH

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"CARD6: a novel caspase recruitment domain (CARD) protein that regulates apoptosis." Bertin J. Submitted (MAR-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT LEU-86.
[2]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Colon.
[4]	"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M. Cell 127:635-648(2006) [PubMed: 17081983] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-468, MASS SPECTROMETRY. Tissue: Epithelium.
+	Additional computationally mapped references.

Cross-references

Sequence databases
	AF356193 mRNA. Translation: AAK32718.1. CH471119 Genomic DNA. Translation: EAW56006.1. BC093825 mRNA. Translation: AAH93825.1.
IPI	IPI00306794.
RefSeq	NP_115976.2.
UniGene	Hs.200242
3D structure databases
ModBase	Search...
PTM databases
PhosphoSite	Q9BX69.
Proteomic databases
PRIDE	Q9BX69.
Genome annotation databases
Ensembl	ENSG00000132357. Homo sapiens. [Contig view]
GeneID	84674.
KEGG	hsa:84674.
Organism-specific databases
GeneCards	GC05P040877.
HGNC	HGNC:16394. CARD6.
MIM	609986. gene.
PharmGKB	PA26076.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	Q9BX69.
HOVERGEN	Q9BX69.
OMA	Q9BX69. YCSFSKS.
Gene expression databases
ArrayExpress	Q9BX69.
Bgee	Q9BX69.
CleanEx	HS_CARD6.
GermOnline	ENSG00000132357. Homo sapiens.
Family and domain databases
InterPro	IPR001315. CARD. [Graphical view]
Pfam	PF00619. CARD. 1 hit. [Graphical view]
PROSITE	PS50209. CARD. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	74685.
SOURCE	Search...

Entry information

Entry name

CARD6_HUMAN

Accession

Primary (citable) accession number: Q9BX69
Secondary accession number(s): Q52LR2

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 2, 2002
Last sequence update:	October 14, 2008
Last modified:	June 16, 2009
This is version 49 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Relevant documents

Human chromosome 5

Human chromosome 5: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents