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Protein

Caspase recruitment domain-containing protein 6

Gene

CARD6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in apoptosis.

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Apoptosis

Names & Taxonomyi

Protein namesi
Recommended name:
Caspase recruitment domain-containing protein 6
Gene namesi
Name:CARD6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:16394. CARD6.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA26076.

Polymorphism and mutation databases

BioMutaiCARD6.
DMDMi209572595.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedCombined sources
Chaini2 – 10371036Caspase recruitment domain-containing protein 6PRO_0000144079Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineCombined sources
Modified residuei154 – 1541PhosphoserineCombined sources
Modified residuei985 – 9851PhosphoserineCombined sources

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9BX69.
MaxQBiQ9BX69.
PaxDbiQ9BX69.
PeptideAtlasiQ9BX69.
PRIDEiQ9BX69.

PTM databases

iPTMnetiQ9BX69.
PhosphoSiteiQ9BX69.

Expressioni

Gene expression databases

BgeeiENSG00000132357.
CleanExiHS_CARD6.
ExpressionAtlasiQ9BX69. baseline and differential.
GenevisibleiQ9BX69. HS.

Organism-specific databases

HPAiHPA036438.

Interactioni

Protein-protein interaction databases

BioGridi124193. 4 interactions.
DIPiDIP-61097N.
STRINGi9606.ENSP00000254691.

Structurei

3D structure databases

ProteinModelPortaliQ9BX69.
SMRiQ9BX69. Positions 4-78.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini3 – 9492CARDPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi201 – 28181Asp/Glu-richAdd
BLAST
Compositional biasi957 – 101256Pro-richAdd
BLAST

Sequence similaritiesi

Contains 1 CARD domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IEZI. Eukaryota.
ENOG410XXII. LUCA.
GeneTreeiENSGT00530000063016.
HOGENOMiHOG000111303.
HOVERGENiHBG094692.
InParanoidiQ9BX69.
KOiK12797.
OMAiYCSFSKS.
OrthoDBiEOG091G01LH.
PhylomeDBiQ9BX69.
TreeFamiTF335271.

Family and domain databases

Gene3Di1.10.533.10. 1 hit.
InterProiIPR001315. CARD.
IPR011029. DEATH-like_dom.
[Graphical view]
PfamiPF00619. CARD. 1 hit.
[Graphical view]
SMARTiSM00114. CARD. 1 hit.
[Graphical view]
SUPFAMiSSF47986. SSF47986. 1 hit.
PROSITEiPS50209. CARD. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9BX69-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATESTPSEI IERERKKLLE ILQHDPDSIL DTLTSRRLIS EEEYETLENV
60 70 80 90 100
TDLLKKSRKL LILVQKKGEA TCQHFLKCLF STFPQSAAIC GLRHEVLKHE
110 120 130 140 150
NTVPPQSMGA SSNSEDAFSP GIKQPEAPEI TVFFSEKEHL DLETSEFFRD
160 170 180 190 200
KKTSYRETAL SARKNEKEYD TPEVTLSYSV EKVGCEVPAT ITYIKDGQRY
210 220 230 240 250
EELDDSLYLG KEEYLGSVDT PEDAEATVEE EVYDDPEHVG YDGEEDFENS
260 270 280 290 300
ETTEFSGEEP SYEGSETSLS LEEEQEKSIE ERKKVFKDVL LCLNMDRSRK
310 320 330 340 350
VLPDFVKQFS LDRGCKWTPE SPGDLAWNFL MKVQARDVTA RDSILSHKVL
360 370 380 390 400
DEDSKEDLLA GVENLEIRDI QTINPLDVLC ATMLCSDSSL QRQVMSNMYQ
410 420 430 440 450
CQFALPLLLP DAENNKSILM LGAMKDIVKK QSTQFSGGPT EDTEKFLTLM
460 470 480 490 500
KMPVISFVRL GYCSFSKSRI LNTLLSPAQL KLHKIFLHQD LPLLVLPRQI
510 520 530 540 550
SDGLVEITWC FPDSDDRKEN PFFQKPVALA NLRGNLESFW TQFGFLMEVS
560 570 580 590 600
SAVFFFTDCL GEKEWDLLMF LGEAAIERCY FVLSSQARES EEAQIFQRIL
610 620 630 640 650
NLKPAQLLFW ERGDAGDRRK NMEGLQAALQ EVMFSSCLRC VSVEDMAALA
660 670 680 690 700
RELGIQVDED FENTQRIQVS SGENMAGTAE GEGQQRHSQL KSSSKSQALM
710 720 730 740 750
PIQEPGTQCE LSQNLQNLYG TPVFRPVLEN SWLFPTRIGG NFNHVSLKAS
760 770 780 790 800
WVMGRPFGSE QRPKWFHPLP FQNAGAQGRG KSFGIQSFHP QIFYSGERFM
810 820 830 840 850
KFSRVARGCH SNGTFGRLPR PICQHVQACP ERPQMMGTLE RSRAVASKIG
860 870 880 890 900
HSYSLDSQPA RAVGKPWPQQ ACTRVTELTE ATGKLIRTSH IGKPHPQSFQ
910 920 930 940 950
PAAATQKLRP ASQQGVQMKT QGGASNPALQ IGSHPMCKSS QFKSDQSNPS
960 970 980 990 1000
TVKHSQPKPF HSVPSQPKSS QTKSCQSQPS QTKPSPCKST QPKPSQPWPP
1010 1020 1030
QSKPSQPRPP QPKSSSTNPS QAKAHHSKAG QKRGGKH
Length:1,037
Mass (Da):116,468
Last modified:October 14, 2008 - v2
Checksum:i366E64BE7AFF164C
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti86 – 861S → L.1 Publication
Corresponds to variant rs10512747 [ dbSNP | Ensembl ].
VAR_046689
Natural varianti93 – 931R → K.
Corresponds to variant rs7715491 [ dbSNP | Ensembl ].
VAR_046690
Natural varianti395 – 3951M → K.
Corresponds to variant rs3812030 [ dbSNP | Ensembl ].
VAR_046691
Natural varianti426 – 4261D → V.
Corresponds to variant rs3812031 [ dbSNP | Ensembl ].
VAR_046692
Natural varianti575 – 5751A → D.
Corresponds to variant rs36085996 [ dbSNP | Ensembl ].
VAR_046693
Natural varianti576 – 5761I → V.
Corresponds to variant rs323562 [ dbSNP | Ensembl ].
VAR_046694

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF356193 mRNA. Translation: AAK32718.1.
CH471119 Genomic DNA. Translation: EAW56006.1.
BC093825 mRNA. Translation: AAH93825.1.
CCDSiCCDS3935.1.
RefSeqiNP_115976.2. NM_032587.3.
UniGeneiHs.200242.

Genome annotation databases

EnsembliENST00000254691; ENSP00000254691; ENSG00000132357.
GeneIDi84674.
KEGGihsa:84674.
UCSCiuc003jmg.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF356193 mRNA. Translation: AAK32718.1.
CH471119 Genomic DNA. Translation: EAW56006.1.
BC093825 mRNA. Translation: AAH93825.1.
CCDSiCCDS3935.1.
RefSeqiNP_115976.2. NM_032587.3.
UniGeneiHs.200242.

3D structure databases

ProteinModelPortaliQ9BX69.
SMRiQ9BX69. Positions 4-78.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124193. 4 interactions.
DIPiDIP-61097N.
STRINGi9606.ENSP00000254691.

PTM databases

iPTMnetiQ9BX69.
PhosphoSiteiQ9BX69.

Polymorphism and mutation databases

BioMutaiCARD6.
DMDMi209572595.

Proteomic databases

EPDiQ9BX69.
MaxQBiQ9BX69.
PaxDbiQ9BX69.
PeptideAtlasiQ9BX69.
PRIDEiQ9BX69.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000254691; ENSP00000254691; ENSG00000132357.
GeneIDi84674.
KEGGihsa:84674.
UCSCiuc003jmg.4. human.

Organism-specific databases

CTDi84674.
GeneCardsiCARD6.
H-InvDBHIX0031999.
HGNCiHGNC:16394. CARD6.
HPAiHPA036438.
MIMi609986. gene.
neXtProtiNX_Q9BX69.
PharmGKBiPA26076.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IEZI. Eukaryota.
ENOG410XXII. LUCA.
GeneTreeiENSGT00530000063016.
HOGENOMiHOG000111303.
HOVERGENiHBG094692.
InParanoidiQ9BX69.
KOiK12797.
OMAiYCSFSKS.
OrthoDBiEOG091G01LH.
PhylomeDBiQ9BX69.
TreeFamiTF335271.

Miscellaneous databases

ChiTaRSiCARD6. human.
GenomeRNAii84674.
PROiQ9BX69.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000132357.
CleanExiHS_CARD6.
ExpressionAtlasiQ9BX69. baseline and differential.
GenevisibleiQ9BX69. HS.

Family and domain databases

Gene3Di1.10.533.10. 1 hit.
InterProiIPR001315. CARD.
IPR011029. DEATH-like_dom.
[Graphical view]
PfamiPF00619. CARD. 1 hit.
[Graphical view]
SMARTiSM00114. CARD. 1 hit.
[Graphical view]
SUPFAMiSSF47986. SSF47986. 1 hit.
PROSITEiPS50209. CARD. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCARD6_HUMAN
AccessioniPrimary (citable) accession number: Q9BX69
Secondary accession number(s): Q52LR2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 2, 2002
Last sequence update: October 14, 2008
Last modified: September 7, 2016
This is version 103 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.